National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14645

TDMS Study 96020-01 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:01:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              FINAL #1                                                              
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 004    300 NG /100 UG                                                                
                                       INCLUDE 005    300 NG /300 UG                                                                
                                       INCLUDE 006    300 NG /3000 UG                                                               
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:01:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF    TEF EVALUATION (BINARY MIXTURE; PCB 126                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Clitoral Gland                         Inflammation                                                                                 
Clitoral Gland: Duct                   Cyst                                                                                         
Eye: Retina                            Atrophy                                                                                      
Kidney                                 Casts Protein                                                                                
                                       Hydronephrosis                                                                               
                                       Infarct                                                                                      
                                       Mineralization                                                                               
                                       Pigmentation                                                                                 
Kidney: Pelvis                         Inflammation                                                                                 
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Fatty Change Focal                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Fibrosis                                                                                     
                                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Infiltration Cellular Histiocyte                                                             
                                       Inflammation                                                                                 
                                       Metaplasia                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia Bronchiolar                                                                       
Lymph Node: Lumbar                     Ectasia                                                                                      
                                       Hyperplasia                                                                                  
Mammary Gland                          Hyperplasia                                                                                  
                                       Inflammation Granulomatous                                                                   
Nose                                   Inflammation                                                                                 
Ovary                                  Atrophy                                                                                      
                                       Inflammation Chronic                                                                         
Oviduct                                Cyst                                                                                         
                                       Inflammation Chronic                                                                         
Pancreas                               Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:01:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
                                       Vacuolization Cytoplasmic                                                                    
Pituitary Gland                        Angiectasis                                                                                  
Skin                                   Inflammation                                                                                 
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Spleen: Lymphoid Follicle              Atrophy                                                                                      
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Inflammation                                                                                 
Stomach, Forestomach: Artery           Inflammation Chronic                                                                         
Stomach, Glandular                     Mineralization                                                                               
Thymus                                 Atrophy                                                                                      
                                       Hyperplasia Lymphoid                                                                         
Thyroid Gland: Follicle                Cyst                                                                                         
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Uterus                                 Inflammation                                                                                 
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  17/53 (32%)              28/49 (57%)              23/52 (44%)              7/51 (14%)      | 
|POLY-3 RATE (b)    |                  17/41.18                 28/41.28                 23/42.61                 7/41.65         | 
|POLY-3 PERCENT (g) |                  41.3%                    67.8%                    54.0%                    16.8%           | 
|TERMINAL (d)       |                  11/22 (50%)              22/28 (79%)              11/24 (46%)              4/27 (15%)      | 
|FIRST INCIDENCE    |                  418                      491                      499                      463             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001N**               P=0.123                  P=0.229                  P=0.007N**      | 
|POLY 3             |                  P<0.001N**               P=0.008 **               P=0.164                  P=0.011N*       | 
|POLY 1.5           |                  P<0.001N**               P=0.009 **               P=0.141                  P=0.014N*       | 
|POLY 6             |                  P<0.001N**               P=0.008 **               P=0.220                  P=0.008N**      | 
|LOGISTIC REGRESSION|                  P<0.001N**               P=0.020 *                P=0.132                  P=0.018N*       | 
|COCH-ARM / FISHERS |                  P<0.001N**               P=0.009 **               P=0.140                  P=0.023N*       | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                2/49 (4%)                3/52 (6%)                5/51 (10%)      | 
|POLY-3 RATE (b)    |                  0/38.18                  2/38.87                  3/37.99                  5/40.32         | 
|POLY-3 PERCENT (g) |                  0.0%                     5.2%                     7.9%                     12.4%           | 
|TERMINAL (d)       |                  0/22 (0%)                2/28 (7%)                2/24 (8%)                3/27 (11%)      | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  539                      647             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.070                  P=0.292                  P=0.133                  P=0.051         | 
|POLY 3             |                  P=0.059                  P=0.240                  P=0.117                  P=0.034 *       | 
|POLY 1.5           |                  P=0.055                  P=0.234                  P=0.115                  P=0.032 *       | 
|POLY 6             |                  P=0.063                  P=0.247                  P=0.119                  P=0.037 *       | 
|LOGISTIC REGRESSION|                  P=0.062                  P=0.292                  P=0.117                  P=0.039 *       | 
|COCH-ARM / FISHERS |                  P=0.051                  P=0.228                  P=0.118                  P=0.026 *       | 
|ORDER RESTRICTED   |                  P=0.015 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  13/53 (25%)              14/49 (29%)              14/52 (27%)              18/51 (35%)     | 
|POLY-3 RATE (b)    |                  13/40.95                 14/42.18                 14/39.87                 18/43.61        | 
|POLY-3 PERCENT (g) |                  31.7%                    33.2%                    35.1%                    41.3%           | 
|TERMINAL (d)       |                  6/22 (27%)               8/28 (29%)               7/24 (29%)               11/27 (41%)     | 
|FIRST INCIDENCE    |                  556                      484                      505                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.256                  P=0.519N                 P=0.521                  P=0.349         | 
|POLY 3             |                  P=0.206                  P=0.538                  P=0.465                  P=0.243         | 
|POLY 1.5           |                  P=0.189                  P=0.501                  P=0.466                  P=0.217         | 
|POLY 6             |                  P=0.216                  P=0.562                  P=0.469                  P=0.261         | 
|LOGISTIC REGRESSION|                  P=0.172                  P=0.442                  P=0.473                  P=0.191         | 
|COCH-ARM / FISHERS |                  P=0.151                  P=0.406                  P=0.477                  P=0.162         | 
|ORDER RESTRICTED   |                  P=0.277                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/53 (21%)              17/49 (35%)              25/52 (48%)              21/51 (41%)     | 
|POLY-3 RATE (b)    |                  11/39.56                 17/40.68                 25/42.59                 21/42.72        | 
|POLY-3 PERCENT (g) |                  27.8%                    41.8%                    58.7%                    49.2%           | 
|TERMINAL (d)       |                  7/22 (32%)               13/28 (46%)              14/24 (58%)              14/27 (52%)     | 
|FIRST INCIDENCE    |                  499                      491                      254                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.298                  P=0.296                  P=0.010 *                P=0.094         | 
|POLY 3             |                  P=0.232                  P=0.134                  P=0.003 **               P=0.033 *       | 
|POLY 1.5           |                  P=0.205                  P=0.118                  P=0.002 **               P=0.027 *       | 
|POLY 6             |                  P=0.267                  P=0.154                  P=0.004 **               P=0.043 *       | 
|LOGISTIC REGRESSION|                  P=0.214                  P=0.139                  P=0.002 **               P=0.033 *       | 
|COCH-ARM / FISHERS |                  P=0.168                  P=0.088                  P=0.003 **               P=0.020 *       | 
|ORDER RESTRICTED   |                  P=0.008 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  47/53 (89%)              42/49 (86%)              41/52 (79%)              40/51 (78%)     | 
|POLY-3 RATE (b)    |                  47/49.32                 42/46.24                 41/44.30                 40/47.73        | 
|POLY-3 PERCENT (g) |                  95.3%                    90.8%                    92.6%                    83.8%           | 
|TERMINAL (d)       |                  21/22 (96%)              26/28 (93%)              24/24 (100%)             24/27 (89%)     | 
|FIRST INCIDENCE    |                  418                      441                      479                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.121N                 P=0.063N                 P=0.163N                 P=0.042N*       | 
|POLY 3             |                  P=0.032N*                P=0.302N                 P=0.441N                 P=0.049N*       | 
|POLY 1.5           |                  P=0.059N                 P=0.287N                 P=0.258N                 P=0.054N        | 
|POLY 6             |                  P=0.021N*                P=0.393N                 P=0.667N                 P=0.056N        | 
|LOGISTIC REGRESSION|                  P=0.075N                 P=0.194N                 P=0.103N                 P=0.055N        | 
|COCH-ARM / FISHERS |                  P=0.184N                 P=0.439N                 P=0.135N                 P=0.125N        | 
|ORDER RESTRICTED   |                  P=0.017N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                3/49 (6%)                0/52 (0%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  1/38.43                  3/39.68                  0/37.39                  2/41.77         | 
|POLY-3 PERCENT (g) |                  2.6%                     7.6%                     0.0%                     4.8%            | 
|TERMINAL (d)       |                  0/22 (0%)                1/28 (4%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  664                      612                      ---                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.531                  P=0.334                  P=0.520N                 P=0.498         | 
|POLY 3             |                  P=0.570                  P=0.316                  P=0.505N                 P=0.529         | 
|POLY 1.5           |                  P=0.555                  P=0.304                  P=0.505N                 P=0.516         | 
|POLY 6             |                  P=0.584                  P=0.330                  P=0.505N                 P=0.541         | 
|LOGISTIC REGRESSION|                  P=0.465                  P=0.284                  P=0.504N                 P=0.336         | 
|COCH-ARM / FISHERS |                  P=0.517                  P=0.280                  P=0.505N                 P=0.485         | 
|ORDER RESTRICTED   |                  P=0.427N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/53 (21%)              15/49 (31%)              10/52 (19%)              13/51 (25%)     | 
|POLY-3 RATE (b)    |                  11/40.49                 15/42.24                 10/40.66                 13/40.68        | 
|POLY-3 PERCENT (g) |                  27.2%                    35.5%                    24.6%                    32.0%           | 
|TERMINAL (d)       |                  6/22 (27%)               7/28 (25%)               3/24 (13%)               10/27 (37%)     | 
|FIRST INCIDENCE    |                  451                      478                      330                      636             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.561                  P=0.409                  P=0.469N                 P=0.577         | 
|POLY 3             |                  P=0.467                  P=0.278                  P=0.495N                 P=0.408         | 
|POLY 1.5           |                  P=0.474                  P=0.243                  P=0.509N                 P=0.398         | 
|POLY 6             |                  P=0.453                  P=0.324                  P=0.472N                 P=0.420         | 
|LOGISTIC REGRESSION|                  P=0.497                  P=0.204                  P=0.521N                 P=0.455         | 
|COCH-ARM / FISHERS |                  P=0.464                  P=0.180                  P=0.520N                 P=0.367         | 
|ORDER RESTRICTED   |                  P=0.499                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  15/52 (29%)              8/49 (16%)               13/52 (25%)              6/49 (12%)      | 
|POLY-3 RATE (b)    |                  15/38.71                 8/39.28                  13/39.45                 6/39.40         | 
|POLY-3 PERCENT (g) |                  38.8%                    20.4%                    33.0%                    15.2%           | 
|TERMINAL (d)       |                  9/21 (43%)               7/28 (25%)               9/24 (38%)               5/26 (19%)      | 
|FIRST INCIDENCE    |                  556                      612                      479                      596             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.036N*                P=0.023N*                P=0.321N                 P=0.009N**      | 
|POLY 3             |                  P=0.040N*                P=0.057N                 P=0.380N                 P=0.015N*       | 
|POLY 1.5           |                  P=0.046N*                P=0.068N                 P=0.397N                 P=0.019N*       | 
|POLY 6             |                  P=0.037N*                P=0.050N                 P=0.360N                 P=0.012N*       | 
|LOGISTIC REGRESSION|                  P=0.038N*                P=0.044N*                P=0.399N                 P=0.013N*       | 
|COCH-ARM / FISHERS |                  P=0.065N                 P=0.103N                 P=0.413N                 P=0.034N*       | 
|ORDER RESTRICTED   |                  P=0.010N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  39/53 (74%)              38/50 (76%)              48/53 (91%)              39/51 (76%)     | 
|POLY-3 RATE (b)    |                  39/51.35                 38/48.54                 48/53.00                 39/48.89        | 
|POLY-3 PERCENT (g) |                  76.0%                    78.3%                    90.6%                    79.8%           | 
|TERMINAL (d)       |                  12/22 (55%)              19/28 (68%)              19/24 (79%)              19/27 (70%)     | 
|FIRST INCIDENCE    |                  85                       441                      96                       233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.270N                 P=0.288N                 P=0.186                  P=0.334N        | 
|POLY 3             |                  P=0.524N                 P=0.484                  P=0.037 *                P=0.412         | 
|POLY 1.5           |                  P=0.487N                 P=0.484                  P=0.029 *                P=0.430         | 
|POLY 6             |                  P=0.562N                 P=0.480                  P=0.048 *                P=0.393         | 
|LOGISTIC REGRESSION|                  P=0.503N                 P=0.369                  P=0.019 *                P=0.375         | 
|COCH-ARM / FISHERS |                  P=0.433N                 P=0.479                  P=0.020 *                P=0.455         | 
|ORDER RESTRICTED   |                  P=0.167                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  45/53 (85%)              38/49 (78%)              40/53 (75%)              40/50 (80%)     | 
|POLY-3 RATE (b)    |                  45/50.91                 38/45.36                 40/48.52                 40/45.91        | 
|POLY-3 PERCENT (g) |                  88.4%                    83.8%                    82.4%                    87.1%           | 
|TERMINAL (d)       |                  18/22 (82%)              25/28 (89%)              17/24 (71%)              24/27 (89%)     | 
|FIRST INCIDENCE    |                  345                      441                      254                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.270N                 P=0.040N*                P=0.253N                 P=0.090N        | 
|POLY 3             |                  P=0.475                  P=0.350N                 P=0.282N                 P=0.551N        | 
|POLY 1.5           |                  P=0.535                  P=0.261N                 P=0.244N                 P=0.438N        | 
|POLY 6             |                  P=0.405                  P=0.513N                 P=0.313N                 P=0.590         | 
|LOGISTIC REGRESSION|                  P=0.509N                 P=0.185N                 P=0.180N                 P=0.269N        | 
|COCH-ARM / FISHERS |                  P=0.575N                 P=0.242N                 P=0.165N                 P=0.346N        | 
|ORDER RESTRICTED   |                  P=0.436N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  38/53 (72%)              41/49 (84%)              43/53 (81%)              41/50 (82%)     | 
|POLY-3 RATE (b)    |                  38/50.38                 41/46.10                 43/48.31                 41/47.73        | 
|POLY-3 PERCENT (g) |                  75.4%                    88.9%                    89.0%                    85.9%           | 
|TERMINAL (d)       |                  13/22 (59%)              25/28 (89%)              21/24 (88%)              22/27 (82%)     | 
|FIRST INCIDENCE    |                  345                      462                      254                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.403N                 P=0.434N                 P=0.346                  P=0.464N        | 
|POLY 3             |                  P=0.411                  P=0.063                  P=0.057                  P=0.138         | 
|POLY 1.5           |                  P=0.411                  P=0.087                  P=0.084                  P=0.158         | 
|POLY 6             |                  P=0.414                  P=0.045 *                P=0.038 *                P=0.122         | 
|LOGISTIC REGRESSION|                  P=0.382                  P=0.123                  P=0.168                  P=0.148         | 
|COCH-ARM / FISHERS |                  P=0.345                  P=0.113                  P=0.180                  P=0.158         | 
|ORDER RESTRICTED   |                  P=0.046 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                0/50 (0%)                3/53 (6%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/39.27                  0/39.59                  3/39.07                  0/39.67         | 
|POLY-3 PERCENT (g) |                  7.6%                     0.0%                     7.7%                     0.0%            | 
|TERMINAL (d)       |                  1/22 (5%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  85                       ---                      499                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.166N                 P=0.107N                 P=0.649N                 P=0.104N        | 
|POLY 3             |                  P=0.172N                 P=0.116N                 P=0.661                  P=0.116N        | 
|POLY 1.5           |                  P=0.175N                 P=0.121N                 P=0.653                  P=0.121N        | 
|POLY 6             |                  P=0.169N                 P=0.112N                 P=0.653N                 P=0.110N        | 
|LOGISTIC REGRESSION|                  P=0.211N                 P=0.204N                 P=0.630N                 P=0.177N        | 
|COCH-ARM / FISHERS |                  P=0.180N                 P=0.132N                 P=0.661N                 P=0.132N        | 
|ORDER RESTRICTED   |                  P=0.052N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Anterior Chamber, Ciliary Body, Cornea                                                                                      | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                2/50 (4%)                1/52 (2%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  2/40.02                  1/37.28                  0/39.98         | 
|POLY-3 PERCENT (g) |                  0.0%                     5.0%                     2.7%                     0.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                1/28 (4%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      603                      580                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.358N                 P=0.275                  P=0.500                  (e)             | 
|POLY 3             |                  P=0.344N                 P=0.247                  P=0.495                  (e)             | 
|POLY 1.5           |                  P=0.353N                 P=0.240                  P=0.493                  (e)             | 
|POLY 6             |                  P=0.336N                 P=0.255                  P=0.500                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.376N                 P=0.234                  P=0.502                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.375N                 P=0.233                  P=0.495                  (e)             | 
|ORDER RESTRICTED   |                  P=0.319N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                0/50 (0%)                2/52 (4%)                5/51 (10%)      | 
|POLY-3 RATE (b)    |                  1/38.18                  0/39.59                  2/36.79                  5/40.52         | 
|POLY-3 PERCENT (g) |                  2.6%                     0.0%                     5.4%                     12.3%           | 
|TERMINAL (d)       |                  1/22 (5%)                0/28 (0%)                2/24 (8%)                3/27 (11%)      | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      729 (T)                  588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.024 *                P=0.452N                 P=0.531                  P=0.157         | 
|POLY 3             |                  P=0.016 *                P=0.493N                 P=0.487                  P=0.114         | 
|POLY 1.5           |                  P=0.015 *                P=0.498N                 P=0.485                  P=0.106         | 
|POLY 6             |                  P=0.017 *                P=0.488N                 P=0.492                  P=0.123         | 
|LOGISTIC REGRESSION|                  P=0.020 *                (e)                      P=0.531                  P=0.117         | 
|COCH-ARM / FISHERS |                  P=0.015 *                P=0.515N                 P=0.493                  P=0.094         | 
|ORDER RESTRICTED   |                  P=0.016 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  20/53 (38%)              15/49 (31%)              14/52 (27%)              17/51 (33%)     | 
|POLY-3 RATE (b)    |                  20/41.85                 15/39.74                 14/39.15                 17/40.73        | 
|POLY-3 PERCENT (g) |                  47.8%                    37.8%                    35.8%                    41.7%           | 
|TERMINAL (d)       |                  10/22 (46%)              13/28 (46%)              10/24 (42%)              14/27 (52%)     | 
|FIRST INCIDENCE    |                  418                      491                      330                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.448N                 P=0.078N                 P=0.131N                 P=0.162N        | 
|POLY 3             |                  P=0.554                  P=0.237N                 P=0.185N                 P=0.366N        | 
|POLY 1.5           |                  P=0.552                  P=0.241N                 P=0.181N                 P=0.364N        | 
|POLY 6             |                  P=0.548                  P=0.254N                 P=0.194N                 P=0.387N        | 
|LOGISTIC REGRESSION|                  P=0.511N                 P=0.177N                 P=0.176N                 P=0.266N        | 
|COCH-ARM / FISHERS |                  P=0.524                  P=0.292N                 P=0.165N                 P=0.396N        | 
|ORDER RESTRICTED   |                  P=0.293N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  22/53 (42%)              18/50 (36%)              26/53 (49%)              25/50 (50%)     | 
|POLY-3 RATE (b)    |                  22/41.41                 18/40.91                 26/41.49                 25/41.97        | 
|POLY-3 PERCENT (g) |                  53.1%                    44.0%                    62.7%                    59.6%           | 
|TERMINAL (d)       |                  14/22 (64%)              13/28 (46%)              17/24 (71%)              17/27 (63%)     | 
|FIRST INCIDENCE    |                  449                      625                      96                       463             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.420                  P=0.101N                 P=0.374                  P=0.510N        | 
|POLY 3             |                  P=0.246                  P=0.264N                 P=0.243                  P=0.348         | 
|POLY 1.5           |                  P=0.223                  P=0.284N                 P=0.249                  P=0.315         | 
|POLY 6             |                  P=0.273                  P=0.246N                 P=0.248                  P=0.386         | 
|LOGISTIC REGRESSION|                  P=0.292                  P=0.205N                 P=0.233                  P=0.409         | 
|COCH-ARM / FISHERS |                  P=0.189                  P=0.356N                 P=0.279                  P=0.253         | 
|ORDER RESTRICTED   |                  P=0.173                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                1/50 (2%)                1/53 (2%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  2/38.76                  1/39.59                  1/37.45                  2/40.67         | 
|POLY-3 PERCENT (g) |                  5.2%                     2.5%                     2.7%                     4.9%            | 
|TERMINAL (d)       |                  0/22 (0%)                1/28 (4%)                0/24 (0%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  636                      729 (T)                  715                      491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.529                  P=0.482N                 P=0.514N                 P=0.674N        | 
|POLY 3             |                  P=0.523                  P=0.493N                 P=0.512N                 P=0.677N        | 
|POLY 1.5           |                  P=0.515                  P=0.499N                 P=0.510N                 P=0.687N        | 
|POLY 6             |                  P=0.531                  P=0.488N                 P=0.513N                 P=0.669N        | 
|LOGISTIC REGRESSION|                  P=0.509                  P=0.497N                 P=0.506N                 P=0.674         | 
|COCH-ARM / FISHERS |                  P=0.499                  P=0.522N                 P=0.500N                 P=0.676         | 
|ORDER RESTRICTED   |                  P=0.535N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum: Artery                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                1/50 (2%)                0/53 (0%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  1/39.59                  0/37.40                  2/40.01         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.5%                     0.0%                     5.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                1/28 (4%)                0/24 (0%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  ---                      720             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.179                  P=0.548                  (e)                      P=0.290         | 
|POLY 3             |                  P=0.162                  P=0.507                  (e)                      P=0.247         | 
|POLY 1.5           |                  P=0.158                  P=0.502                  (e)                      P=0.241         | 
|POLY 6             |                  P=0.167                  P=0.512                  (e)                      P=0.254         | 
|LOGISTIC REGRESSION|                  P=0.173                  P=0.548                  (e)                      P=0.268         | 
|COCH-ARM / FISHERS |                  P=0.148                  P=0.485                  (e)                      P=0.238         | 
|ORDER RESTRICTED   |                  P=0.080                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/50 (0%)                2/52 (4%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/39.59                  2/38.30                  0/39.98         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     5.2%                     0.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                1/24 (4%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      330                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.546N                 (e)                      P=0.243                  (e)             | 
|POLY 3             |                  P=0.551N                 (e)                      P=0.237                  (e)             | 
|POLY 1.5           |                  P=0.555N                 (e)                      P=0.235                  (e)             | 
|POLY 6             |                  P=0.546N                 (e)                      P=0.240                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.598N                 (e)                      P=0.237                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.560N                 (e)                      P=0.243                  (e)             | 
|ORDER RESTRICTED   |                  P=0.247                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                0/48 (0%)                1/52 (2%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  2/39.63                  0/38.21                  1/38.39                  2/40.75         | 
|POLY-3 PERCENT (g) |                  5.1%                     0.0%                     2.6%                     4.9%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  449                      ---                      142                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.413                  P=0.237N                 P=0.497N                 P=0.680N        | 
|POLY 3             |                  P=0.410                  P=0.245N                 P=0.511N                 P=0.685N        | 
|POLY 1.5           |                  P=0.405                  P=0.248N                 P=0.509N                 P=0.692N        | 
|POLY 6             |                  P=0.416                  P=0.240N                 P=0.512N                 P=0.675N        | 
|LOGISTIC REGRESSION|                  P=0.303                  P=0.382N                 P=0.480N                 P=0.616         | 
|COCH-ARM / FISHERS |                  P=0.400                  P=0.273N                 P=0.507N                 P=0.676         | 
|ORDER RESTRICTED   |                  P=0.412N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/53 (13%)               6/48 (13%)               4/52 (8%)                6/51 (12%)      | 
|POLY-3 RATE (b)    |                  7/38.73                  6/39.79                  4/39.34                  6/41.82         | 
|POLY-3 PERCENT (g) |                  18.1%                    15.1%                    10.2%                    14.4%           | 
|TERMINAL (d)       |                  5/22 (23%)               2/28 (7%)                0/24 (0%)                3/27 (11%)      | 
|FIRST INCIDENCE    |                  647                      491                      499                      462             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.557N                 P=0.397N                 P=0.253N                 P=0.402N        | 
|POLY 3             |                  P=0.562N                 P=0.479N                 P=0.248N                 P=0.440N        | 
|POLY 1.5           |                  P=0.576N                 P=0.511N                 P=0.261N                 P=0.471N        | 
|POLY 6             |                  P=0.554N                 P=0.441N                 P=0.229N                 P=0.410N        | 
|LOGISTIC REGRESSION|                  P=0.582                  P=0.516N                 P=0.274N                 P=0.493N        | 
|COCH-ARM / FISHERS |                  P=0.577                  P=0.577N                 P=0.274N                 P=0.530N        | 
|ORDER RESTRICTED   |                  P=0.365N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Casts Protein                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                0/48 (0%)                0/52 (0%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  2/39.30                  0/38.21                  0/37.39                  0/39.98         | 
|POLY-3 PERCENT (g) |                  5.1%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  345                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.413N                 P=0.236N                 P=0.249N                 P=0.233N        | 
|POLY 3             |                  P=0.417N                 P=0.243N                 P=0.248N                 P=0.233N        | 
|POLY 1.5           |                  P=0.418N                 P=0.247N                 P=0.246N                 P=0.237N        | 
|POLY 6             |                  P=0.417N                 P=0.237N                 P=0.248N                 P=0.228N        | 
|LOGISTIC REGRESSION|                  P=0.459N                 P=0.351N                 P=0.234N                 P=0.301N        | 
|COCH-ARM / FISHERS |                  P=0.421N                 P=0.273N                 P=0.252N                 P=0.257N        | 
|ORDER RESTRICTED   |                  P=0.028N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/48 (0%)                0/52 (0%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/38.21                  0/37.39                  2/40.51         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.9%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      647             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.053                  (e)                      (e)                      P=0.248         | 
|POLY 3             |                  P=0.049 *                (e)                      (e)                      P=0.250         | 
|POLY 1.5           |                  P=0.047 *                (e)                      (e)                      P=0.242         | 
|POLY 6             |                  P=0.050                  (e)                      (e)                      P=0.260         | 
|LOGISTIC REGRESSION|                  P=0.048 *                (e)                      (e)                      P=0.234         | 
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.238         | 
|ORDER RESTRICTED   |                  P=0.034 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/48 (0%)                0/52 (0%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/38.21                  0/37.39                  2/40.21         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     5.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      668             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.058                  (e)                      (e)                      P=0.278         | 
|POLY 3             |                  P=0.048 *                (e)                      (e)                      P=0.248         | 
|POLY 1.5           |                  P=0.047 *                (e)                      (e)                      P=0.242         | 
|POLY 6             |                  P=0.049 *                (e)                      (e)                      P=0.256         | 
|LOGISTIC REGRESSION|                  P=0.052                  (e)                      (e)                      P=0.250         | 
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.238         | 
|ORDER RESTRICTED   |                  P=0.033 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/53 (9%)                6/48 (13%)               5/52 (10%)               3/51 (6%)       | 
|POLY-3 RATE (b)    |                  5/38.24                  6/38.87                  5/37.96                  3/39.98         | 
|POLY-3 PERCENT (g) |                  13.1%                    15.4%                    13.2%                    7.5%            | 
|TERMINAL (d)       |                  4/22 (18%)               4/28 (14%)               4/24 (17%)               3/27 (11%)      | 
|FIRST INCIDENCE    |                  714                      633                      552                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.191N                 P=0.625                  P=0.584N                 P=0.248N        | 
|POLY 3             |                  P=0.205N                 P=0.512                  P=0.628                  P=0.330N        | 
|POLY 1.5           |                  P=0.215N                 P=0.484                  P=0.621                  P=0.346N        | 
|POLY 6             |                  P=0.199N                 P=0.545                  P=0.628N                 P=0.314N        | 
|LOGISTIC REGRESSION|                  P=0.197N                 P=0.532                  P=0.630                  P=0.257N        | 
|COCH-ARM / FISHERS |                  P=0.237N                 P=0.430                  P=0.617                  P=0.380N        | 
|ORDER RESTRICTED   |                  P=0.285N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  42/53 (79%)              39/48 (81%)              42/52 (81%)              33/51 (65%)     | 
|POLY-3 RATE (b)    |                  42/50.36                 39/47.30                 42/48.93                 33/46.82        | 
|POLY-3 PERCENT (g) |                  83.4%                    82.5%                    85.8%                    70.5%           | 
|TERMINAL (d)       |                  15/22 (68%)              22/28 (79%)              19/24 (79%)              19/27 (70%)     | 
|FIRST INCIDENCE    |                  85                       441                      254                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.046N*                P=0.165N                 P=0.498N                 P=0.041N*       | 
|POLY 3             |                  P=0.032N*                P=0.559N                 P=0.476                  P=0.089N        | 
|POLY 1.5           |                  P=0.022N*                P=0.604                  P=0.466                  P=0.078N        | 
|POLY 6             |                  P=0.057N                 P=0.531N                 P=0.481                  P=0.123N        | 
|LOGISTIC REGRESSION|                  P=0.020N*                P=0.432                  P=0.519                  P=0.083N        | 
|COCH-ARM / FISHERS |                  P=0.018N*                P=0.500                  P=0.520                  P=0.076N        | 
|ORDER RESTRICTED   |                  P=0.057N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  29/53 (55%)              30/48 (63%)              34/52 (65%)              34/51 (67%)     | 
|POLY-3 RATE (b)    |                  29/44.67                 30/41.51                 34/43.59                 34/43.74        | 
|POLY-3 PERCENT (g) |                  64.9%                    72.3%                    78.0%                    77.7%           | 
|TERMINAL (d)       |                  17/22 (77%)              23/28 (82%)              23/24 (96%)              24/27 (89%)     | 
|FIRST INCIDENCE    |                  345                      478                      142                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.476                  P=0.276N                 P=0.320                  P=0.550         | 
|POLY 3             |                  P=0.215                  P=0.294                  P=0.108                  P=0.115         | 
|POLY 1.5           |                  P=0.229                  P=0.303                  P=0.137                  P=0.132         | 
|POLY 6             |                  P=0.204                  P=0.284                  P=0.084                  P=0.101         | 
|LOGISTIC REGRESSION|                  P=0.333                  P=0.413                  P=0.165                  P=0.232         | 
|COCH-ARM / FISHERS |                  P=0.247                  P=0.278                  P=0.180                  P=0.148         | 
|ORDER RESTRICTED   |                  P=0.095                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                2/48 (4%)                7/52 (13%)               17/51 (33%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  2/38.62                  7/38.16                  17/42.67        | 
|POLY-3 PERCENT (g) |                  0.0%                     5.2%                     18.3%                    39.8%           | 
|TERMINAL (d)       |                  0/22 (0%)                1/28 (4%)                6/24 (25%)               10/27 (37%)     | 
|FIRST INCIDENCE    |                  ---                      612                      451                      491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.272                  P=0.011 *                P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P=0.239                  P=0.007 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P=0.231                  P=0.007 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P=0.248                  P=0.007 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.227                  P=0.008 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.223                  P=0.006 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                4/48 (8%)                2/52 (4%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  1/38.18                  4/39.17                  2/37.83                  0/39.98         | 
|POLY-3 PERCENT (g) |                  2.6%                     10.2%                    5.3%                     0.0%            | 
|TERMINAL (d)       |                  1/22 (5%)                2/28 (7%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  478                      618                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.124N                 P=0.232                  P=0.506                  P=0.459N        | 
|POLY 3             |                  P=0.110N                 P=0.185                  P=0.497                  P=0.491N        | 
|POLY 1.5           |                  P=0.117N                 P=0.173                  P=0.493                  P=0.496N        | 
|POLY 6             |                  P=0.105N                 P=0.199                  P=0.504                  P=0.485N        | 
|LOGISTIC REGRESSION|                  P=0.128N                 P=0.163                  P=0.494                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.133N                 P=0.152                  P=0.493                  P=0.510N        | 
|ORDER RESTRICTED   |                  P=0.127N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                1/48 (2%)                3/52 (6%)                8/51 (16%)      | 
|POLY-3 RATE (b)    |                  3/39.42                  1/38.73                  3/38.07                  8/40.77         | 
|POLY-3 PERCENT (g) |                  7.6%                     2.6%                     7.9%                     19.6%           | 
|TERMINAL (d)       |                  1/22 (5%)                0/28 (0%)                2/24 (8%)                6/27 (22%)      | 
|FIRST INCIDENCE    |                  499                      569                      499                      556             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.016 *                P=0.279N                 P=0.637N                 P=0.161         | 
|POLY 3             |                  P=0.010 *                P=0.310N                 P=0.648                  P=0.105         | 
|POLY 1.5           |                  P=0.009 **               P=0.319N                 P=0.648                  P=0.100         | 
|POLY 6             |                  P=0.010 *                P=0.301N                 P=0.649                  P=0.112         | 
|LOGISTIC REGRESSION|                  P=0.011 *                P=0.398N                 P=0.654                  P=0.103         | 
|COCH-ARM / FISHERS |                  P=0.009 **               P=0.347N                 P=0.652                  P=0.089         | 
|ORDER RESTRICTED   |                  P=0.015 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/48 (0%)                2/52 (4%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/38.21                  2/37.67                  0/39.98         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     5.3%                     0.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                1/24 (4%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      654                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.545N                 (e)                      P=0.239                  (e)             | 
|POLY 3             |                  P=0.549N                 (e)                      P=0.233                  (e)             | 
|POLY 1.5           |                  P=0.552N                 (e)                      P=0.232                  (e)             | 
|POLY 6             |                  P=0.546N                 (e)                      P=0.237                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.544N                 (e)                      P=0.233                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.557N                 (e)                      P=0.243                  (e)             | 
|ORDER RESTRICTED   |                  P=0.244                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                6/48 (13%)               11/52 (21%)              9/51 (18%)      | 
|POLY-3 RATE (b)    |                  2/38.18                  6/39.39                  11/39.29                 9/40.65         | 
|POLY-3 PERCENT (g) |                  5.2%                     15.2%                    28.0%                    22.1%           | 
|TERMINAL (d)       |                  2/22 (9%)                3/28 (11%)               7/24 (29%)               7/27 (26%)      | 
|FIRST INCIDENCE    |                  729 (T)                  569                      539                      601             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.240                  P=0.190                  P=0.012 *                P=0.052         | 
|POLY 3             |                  P=0.202                  P=0.140                  P=0.007 **               P=0.030 *       | 
|POLY 1.5           |                  P=0.191                  P=0.127                  P=0.006 **               P=0.027 *       | 
|POLY 6             |                  P=0.214                  P=0.159                  P=0.008 **               P=0.035 *       | 
|LOGISTIC REGRESSION|                  P=0.207                  P=0.130                  P=0.007 **               P=0.035 *       | 
|COCH-ARM / FISHERS |                  P=0.174                  P=0.105                  P=0.007 **               P=0.022 *       | 
|ORDER RESTRICTED   |                  P=0.012 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                1/50 (2%)                2/52 (4%)                3/51 (6%)       | 
|POLY-3 RATE (b)    |                  3/38.74                  1/39.59                  2/37.66                  3/40.43         | 
|POLY-3 PERCENT (g) |                  7.7%                     2.5%                     5.3%                     7.4%            | 
|TERMINAL (d)       |                  2/22 (9%)                1/28 (4%)                1/24 (4%)                2/27 (7%)       | 
|FIRST INCIDENCE    |                  556                      729 (T)                  659                      596             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.467                  P=0.242N                 P=0.487N                 P=0.586N        | 
|POLY 3             |                  P=0.437                  P=0.296N                 P=0.513N                 P=0.644N        | 
|POLY 1.5           |                  P=0.430                  P=0.304N                 P=0.513N                 P=0.655N        | 
|POLY 6             |                  P=0.447                  P=0.290N                 P=0.510N                 P=0.631N        | 
|LOGISTIC REGRESSION|                  P=0.443                  P=0.294N                 P=0.509N                 P=0.652N        | 
|COCH-ARM / FISHERS |                  P=0.417                  P=0.331N                 P=0.509N                 P=0.642         | 
|ORDER RESTRICTED   |                  P=0.483N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  22/53 (42%)              5/50 (10%)               3/52 (6%)                18/51 (35%)     | 
|POLY-3 RATE (b)    |                  22/43.23                 5/39.94                  3/37.45                  18/42.98        | 
|POLY-3 PERCENT (g) |                  50.9%                    12.5%                    8.0%                     41.9%           | 
|TERMINAL (d)       |                  9/22 (41%)               3/28 (11%)               2/24 (8%)                9/27 (33%)      | 
|FIRST INCIDENCE    |                  377                      664                      715                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.089                  P<0.001N**               P<0.001N**               P=0.163N        | 
|POLY 3             |                  P=0.046 *                P<0.001N**               P<0.001N**               P=0.262N        | 
|POLY 1.5           |                  P=0.036 *                P<0.001N**               P<0.001N**               P=0.282N        | 
|POLY 6             |                  P=0.067                  P<0.001N**               P<0.001N**               P=0.237N        | 
|LOGISTIC REGRESSION|                  P=0.045 *                P<0.001N**               P<0.001N**               P=0.265N        | 
|COCH-ARM / FISHERS |                  P=0.036 *                P<0.001N**               P<0.001N**               P=0.327N        | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                5/50 (10%)               7/52 (13%)               13/51 (25%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  5/39.94                  7/37.86                  13/41.27        | 
|POLY-3 PERCENT (g) |                  0.0%                     12.5%                    18.5%                    31.5%           | 
|TERMINAL (d)       |                  0/22 (0%)                3/28 (11%)               5/24 (21%)               10/27 (37%)     | 
|FIRST INCIDENCE    |                  ---                      664                      612                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.052                  P=0.012 *                P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P=0.033 *                P=0.007 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P=0.031 *                P=0.007 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P=0.036 *                P=0.007 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.038 *                P=0.008 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.024 *                P=0.006 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/53 (17%)               5/50 (10%)               3/52 (6%)                11/51 (22%)     | 
|POLY-3 RATE (b)    |                  9/38.43                  5/39.59                  3/37.39                  11/41.02        | 
|POLY-3 PERCENT (g) |                  23.4%                    12.6%                    8.0%                     26.8%           | 
|TERMINAL (d)       |                  8/22 (36%)               5/28 (18%)               3/24 (13%)               9/27 (33%)      | 
|FIRST INCIDENCE    |                  664                      729 (T)                  729 (T)                  463             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.091                  P=0.082N                 P=0.039N*                P=0.578         | 
|POLY 3             |                  P=0.075                  P=0.169N                 P=0.060N                 P=0.464         | 
|POLY 1.5           |                  P=0.069                  P=0.186N                 P=0.063N                 P=0.429         | 
|POLY 6             |                  P=0.082                  P=0.155N                 P=0.056N                 P=0.503         | 
|LOGISTIC REGRESSION|                  P=0.084                  P=0.117N                 P=0.045N*                P=0.476         | 
|COCH-ARM / FISHERS |                  P=0.061                  P=0.229N                 P=0.066N                 P=0.365         | 
|ORDER RESTRICTED   |                  P=0.114                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  14/53 (26%)              27/50 (54%)              40/52 (77%)              45/51 (88%)     | 
|POLY-3 RATE (b)    |                  14/42.00                 27/46.61                 40/47.53                 45/47.97        | 
|POLY-3 PERCENT (g) |                  33.3%                    57.9%                    84.2%                    93.8%           | 
|TERMINAL (d)       |                  4/22 (18%)               11/28 (39%)              18/24 (75%)              26/27 (96%)     | 
|FIRST INCIDENCE    |                  451                      441                      330                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.052                  P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P=0.014 *                P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P=0.009 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P=0.025 *                P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.004 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.004 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                28/50 (56%)              31/52 (60%)              47/51 (92%)     | 
|POLY-3 RATE (b)    |                  3/39.19                  28/45.86                 31/45.69                 47/49.08        | 
|POLY-3 PERCENT (g) |                  7.7%                     61.1%                    67.8%                    95.8%           | 
|TERMINAL (d)       |                  1/22 (5%)                15/28 (54%)              15/24 (63%)              27/27 (100%)    | 
|FIRST INCIDENCE    |                  449                      441                      254                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                4/50 (8%)                1/52 (2%)                11/51 (22%)     | 
|POLY-3 RATE (b)    |                  3/38.27                  4/40.12                  1/37.83                  11/41.62        | 
|POLY-3 PERCENT (g) |                  7.8%                     10.0%                    2.6%                     26.4%           | 
|TERMINAL (d)       |                  2/22 (9%)                3/28 (11%)               0/24 (0%)                7/27 (26%)      | 
|FIRST INCIDENCE    |                  708                      567                      603                      491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.002 **               P=0.609                  P=0.288N                 P=0.049 *       | 
|POLY 3             |                  P<0.001 **               P=0.526                  P=0.308N                 P=0.027 *       | 
|POLY 1.5           |                  P<0.001 **               P=0.508                  P=0.312N                 P=0.022 *       | 
|POLY 6             |                  P<0.001 **               P=0.544                  P=0.301N                 P=0.033 *       | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.531                  P=0.310N                 P=0.026 *       | 
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.467                  P=0.316N                 P=0.017 *       | 
|ORDER RESTRICTED   |                  P=0.003 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  27/53 (51%)              18/50 (36%)              19/52 (37%)              29/51 (57%)     | 
|POLY-3 RATE (b)    |                  27/49.38                 18/44.86                 19/44.94                 29/46.24        | 
|POLY-3 PERCENT (g) |                  54.7%                    40.1%                    42.3%                    62.7%           | 
|TERMINAL (d)       |                  5/22 (23%)               9/28 (32%)               6/24 (25%)               16/27 (59%)     | 
|FIRST INCIDENCE    |                  85                       441                      142                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.161                  P=0.060N                 P=0.143N                 P=0.507N        | 
|POLY 3             |                  P=0.040 *                P=0.110N                 P=0.156N                 P=0.274         | 
|POLY 1.5           |                  P=0.041 *                P=0.096N                 P=0.130N                 P=0.301         | 
|POLY 6             |                  P=0.039 *                P=0.140N                 P=0.189N                 P=0.238         | 
|LOGISTIC REGRESSION|                  P=0.029 *                P=0.174N                 P=0.083N                 P=0.264         | 
|COCH-ARM / FISHERS |                  P=0.048 *                P=0.092N                 P=0.098N                 P=0.342         | 
|ORDER RESTRICTED   |                  P=0.064                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                20/50 (40%)              24/52 (46%)              21/51 (41%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  20/40.25                 24/39.96                 21/41.77        | 
|POLY-3 PERCENT (g) |                  0.0%                     49.7%                    60.1%                    50.3%           | 
|TERMINAL (d)       |                  0/22 (0%)                18/28 (64%)              16/24 (67%)              15/27 (56%)     | 
|FIRST INCIDENCE    |                  ---                      633                      552                      602             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.060                  P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P=0.035 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P=0.026 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P=0.055                  P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P=0.039 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P=0.026 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  44/53 (83%)              47/50 (94%)              48/52 (92%)              46/51 (90%)     | 
|POLY-3 RATE (b)    |                  44/50.14                 47/48.90                 48/50.71                 46/49.21        | 
|POLY-3 PERCENT (g) |                  87.8%                    96.1%                    94.7%                    93.5%           | 
|TERMINAL (d)       |                  19/22 (86%)              27/28 (96%)              23/24 (96%)              26/27 (96%)     | 
|FIRST INCIDENCE    |                  85                       441                      254                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.325N                 P=0.377N                 P=0.407                  P=0.344N        | 
|POLY 3             |                  P=0.527                  P=0.102                  P=0.175                  P=0.247         | 
|POLY 1.5           |                  P=0.506                  P=0.088                  P=0.129                  P=0.216         | 
|POLY 6             |                  P=0.548                  P=0.122                  P=0.238                  P=0.284         | 
|LOGISTIC REGRESSION|                  P=0.554                  P=0.092                  P=0.123                  P=0.253         | 
|COCH-ARM / FISHERS |                  P=0.511                  P=0.075                  P=0.125                  P=0.217         | 
|ORDER RESTRICTED   |                  P=0.106                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  26/53 (49%)              27/50 (54%)              26/52 (50%)              27/51 (53%)     | 
|POLY-3 RATE (b)    |                  26/43.18                 27/41.19                 26/38.98                 27/43.00        | 
|POLY-3 PERCENT (g) |                  60.2%                    65.6%                    66.7%                    62.8%           | 
|TERMINAL (d)       |                  16/22 (73%)              24/28 (86%)              23/24 (96%)              21/27 (78%)     | 
|FIRST INCIDENCE    |                  377                      462                      499                      463             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.401N                 P=0.275N                 P=0.456N                 P=0.353N        | 
|POLY 3             |                  P=0.533N                 P=0.381                  P=0.341                  P=0.490         | 
|POLY 1.5           |                  P=0.555                  P=0.410                  P=0.424                  P=0.474         | 
|POLY 6             |                  P=0.469N                 P=0.312                  P=0.238                  P=0.499         | 
|LOGISTIC REGRESSION|                  P=0.516N                 P=0.570                  P=0.536                  P=0.559         | 
|COCH-ARM / FISHERS |                  P=0.463                  P=0.380                  P=0.539                  P=0.421         | 
|ORDER RESTRICTED   |                  P=0.486                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/53 (8%)                6/50 (12%)               4/52 (8%)                7/51 (14%)      | 
|POLY-3 RATE (b)    |                  4/39.53                  6/41.80                  4/38.13                  7/42.46         | 
|POLY-3 PERCENT (g) |                  10.1%                    14.4%                    10.5%                    16.5%           | 
|TERMINAL (d)       |                  0/22 (0%)                1/28 (4%)                2/24 (8%)                2/27 (7%)       | 
|FIRST INCIDENCE    |                  533                      484                      552                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.298                  P=0.397                  P=0.636                  P=0.311         | 
|POLY 3             |                  P=0.298                  P=0.404                  P=0.625                  P=0.301         | 
|POLY 1.5           |                  P=0.280                  P=0.382                  P=0.626                  P=0.280         | 
|POLY 6             |                  P=0.316                  P=0.426                  P=0.624                  P=0.322         | 
|LOGISTIC REGRESSION|                  P=0.231                  P=0.294                  P=0.632                  P=0.214         | 
|COCH-ARM / FISHERS |                  P=0.243                  P=0.334                  P=0.631                  P=0.241         | 
|ORDER RESTRICTED   |                  P=0.307                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                50/50 (100%)             50/52 (96%)              44/51 (86%)     | 
|POLY-3 RATE (b)    |                  2/38.18                  50/50.00                 50/50.05                 44/48.31        | 
|POLY-3 PERCENT (g) |                  5.2%                     100.0%                   99.9%                    91.1%           | 
|TERMINAL (d)       |                  2/22 (9%)                28/28 (100%)             24/24 (100%)             27/27 (100%)    | 
|FIRST INCIDENCE    |                  729 (T)                  441                      310                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.032 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                44/50 (88%)              48/52 (92%)              48/51 (94%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  44/46.21                 48/48.25                 48/49.68        | 
|POLY-3 PERCENT (g) |                  0.0%                     95.2%                    99.5%                    96.6%           | 
|TERMINAL (d)       |                  0/22 (0%)                28/28 (100%)             24/24 (100%)             27/27 (100%)    | 
|FIRST INCIDENCE    |                  ---                      462                      330                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/53 (8%)                4/50 (8%)                5/52 (10%)               6/51 (12%)      | 
|POLY-3 RATE (b)    |                  4/38.46                  4/39.59                  5/37.44                  6/40.36         | 
|POLY-3 PERCENT (g) |                  10.4%                    10.1%                    13.4%                    14.9%           | 
|TERMINAL (d)       |                  3/22 (14%)               4/28 (14%)               4/24 (17%)               5/27 (19%)      | 
|FIRST INCIDENCE    |                  654                      729 (T)                  719                      622             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.385                  P=0.531N                 P=0.542                  P=0.471         | 
|POLY 3             |                  P=0.349                  P=0.629N                 P=0.483                  P=0.399         | 
|POLY 1.5           |                  P=0.336                  P=0.641N                 P=0.483                  P=0.381         | 
|POLY 6             |                  P=0.365                  P=0.619N                 P=0.485                  P=0.418         | 
|LOGISTIC REGRESSION|                  P=0.373                  P=0.592N                 P=0.510                  P=0.422         | 
|COCH-ARM / FISHERS |                  P=0.311                  P=0.609                  P=0.488                  P=0.346         | 
|ORDER RESTRICTED   |                  P=0.418                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                0/50 (0%)                4/52 (8%)                5/51 (10%)      | 
|POLY-3 RATE (b)    |                  1/38.41                  0/39.59                  4/38.64                  5/41.42         | 
|POLY-3 PERCENT (g) |                  2.6%                     0.0%                     10.4%                    12.1%           | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                1/24 (4%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  670                      ---                      506                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.070                  P=0.486N                 P=0.188                  P=0.149         | 
|POLY 3             |                  P=0.054                  P=0.494N                 P=0.178                  P=0.118         | 
|POLY 1.5           |                  P=0.050                  P=0.499N                 P=0.175                  P=0.109         | 
|POLY 6             |                  P=0.060                  P=0.490N                 P=0.186                  P=0.130         | 
|LOGISTIC REGRESSION|                  P=0.046 *                P=0.501N                 P=0.173                  P=0.096         | 
|COCH-ARM / FISHERS |                  P=0.047 *                P=0.515N                 P=0.176                  P=0.094         | 
|ORDER RESTRICTED   |                  P=0.031 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/53 (15%)               20/50 (40%)              29/52 (56%)              40/51 (78%)     | 
|POLY-3 RATE (b)    |                  8/39.10                  20/41.49                 29/42.15                 40/45.51        | 
|POLY-3 PERCENT (g) |                  20.5%                    48.2%                    68.8%                    87.9%           | 
|TERMINAL (d)       |                  5/22 (23%)               14/28 (50%)              17/24 (71%)              26/27 (96%)     | 
|FIRST INCIDENCE    |                  533                      484                      505                      462             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.031 *                P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P=0.006 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P=0.005 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P=0.007 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.008 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.004 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/53 (9%)                6/50 (12%)               4/52 (8%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  5/39.53                  6/41.72                  4/38.67                  2/41.55         | 
|POLY-3 PERCENT (g) |                  12.7%                    14.4%                    10.3%                    4.8%            | 
|TERMINAL (d)       |                  1/22 (5%)                2/28 (7%)                1/24 (4%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  449                      478                      552                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.136N                 P=0.563                  P=0.501N                 P=0.194N        | 
|POLY 3             |                  P=0.119N                 P=0.538                  P=0.514N                 P=0.194N        | 
|POLY 1.5           |                  P=0.126N                 P=0.514                  P=0.516N                 P=0.206N        | 
|POLY 6             |                  P=0.115N                 P=0.561                  P=0.507N                 P=0.185N        | 
|LOGISTIC REGRESSION|                  P=0.160N                 P=0.426                  P=0.513N                 P=0.276N        | 
|COCH-ARM / FISHERS |                  P=0.146N                 P=0.459                  P=0.512N                 P=0.235N        | 
|ORDER RESTRICTED   |                  P=0.153N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                22/50 (44%)              33/52 (63%)              47/51 (92%)     | 
|POLY-3 RATE (b)    |                  1/38.74                  22/45.91                 33/47.28                 47/48.94        | 
|POLY-3 PERCENT (g) |                  2.6%                     47.9%                    69.8%                    96.0%           | 
|TERMINAL (d)       |                  0/22 (0%)                8/28 (29%)               14/24 (58%)              27/27 (100%)    | 
|FIRST INCIDENCE    |                  556                      441                      254                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                42/50 (84%)              46/52 (88%)              44/51 (86%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  42/46.55                 46/47.78                 44/47.16        | 
|POLY-3 PERCENT (g) |                  0.0%                     90.2%                    96.3%                    93.3%           | 
|TERMINAL (d)       |                  0/22 (0%)                27/28 (96%)              23/24 (96%)              27/27 (100%)    | 
|FIRST INCIDENCE    |                  ---                      441                      310                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.002 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                33/50 (66%)              39/52 (75%)              43/51 (84%)     | 
|POLY-3 RATE (b)    |                  2/38.18                  33/43.22                 39/43.48                 43/46.51        | 
|POLY-3 PERCENT (g) |                  5.2%                     76.4%                    89.7%                    92.5%           | 
|TERMINAL (d)       |                  2/22 (9%)                23/28 (82%)              22/24 (92%)              27/27 (100%)    | 
|FIRST INCIDENCE    |                  729 (T)                  484                      499                      462             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                3/50 (6%)                7/52 (13%)               10/51 (20%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  3/39.90                  7/37.83                  10/41.29        | 
|POLY-3 PERCENT (g) |                  0.0%                     7.5%                     18.5%                    24.2%           | 
|TERMINAL (d)       |                  0/22 (0%)                2/28 (7%)                6/24 (25%)               7/27 (26%)      | 
|FIRST INCIDENCE    |                  ---                      643                      603                      490             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.007 **               P=0.148                  P=0.011 *                P=0.003 **      | 
|POLY 3             |                  P=0.004 **               P=0.126                  P=0.007 **               P<0.001 **      | 
|POLY 1.5           |                  P=0.004 **               P=0.121                  P=0.007 **               P<0.001 **      | 
|POLY 6             |                  P=0.005 **               P=0.132                  P=0.007 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P=0.005 **               P=0.129                  P=0.008 **               P=0.002 **      | 
|COCH-ARM / FISHERS |                  P=0.004 **               P=0.111                  P=0.006 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  47/53 (89%)              49/50 (98%)              46/53 (87%)              40/50 (80%)     | 
|POLY-3 RATE (b)    |                  47/48.79                 49/49.59                 46/46.97                 40/45.90        | 
|POLY-3 PERCENT (g) |                  96.3%                    98.8%                    97.9%                    87.1%           | 
|TERMINAL (d)       |                  22/22 (100%)             28/28 (100%)             24/24 (100%)             25/27 (93%)     | 
|FIRST INCIDENCE    |                  345                      441                      254                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.031N*                P=0.298N                 P=0.413N                 P=0.033N*       | 
|POLY 3             |                  P<0.001N**               P=0.422                  P=0.583                  P=0.068N        | 
|POLY 1.5           |                  P=0.002N**               P=0.229                  P=0.593                  P=0.085N        | 
|POLY 6             |                  P<0.001N**               P=0.700                  P=0.697                  P=0.073N        | 
|LOGISTIC REGRESSION|                  P<0.001N**               P=0.219                  P=0.584                  P=0.050N        | 
|COCH-ARM / FISHERS |                  P=0.027N*                P=0.066                  P=0.500N                 P=0.173N        | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/53 (15%)               2/50 (4%)                4/53 (8%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  8/40.26                  2/39.59                  4/38.58                  2/40.50         | 
|POLY-3 PERCENT (g) |                  19.9%                    5.1%                     10.4%                    4.9%            | 
|TERMINAL (d)       |                  4/22 (18%)               2/28 (7%)                2/24 (8%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  85                       729 (T)                  330                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.139N                 P=0.032N*                P=0.181N                 P=0.040N*       | 
|POLY 3             |                  P=0.142N                 P=0.045N*                P=0.193N                 P=0.042N*       | 
|POLY 1.5           |                  P=0.152N                 P=0.048N*                P=0.194N                 P=0.047N*       | 
|POLY 6             |                  P=0.130N                 P=0.043N*                P=0.191N                 P=0.037N*       | 
|LOGISTIC REGRESSION|                  P=0.178N                 P=0.062N                 P=0.175N                 P=0.070N        | 
|COCH-ARM / FISHERS |                  P=0.170N                 P=0.056N                 P=0.179N                 P=0.056N        | 
|ORDER RESTRICTED   |                  P=0.015N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                3/50 (6%)                2/53 (4%)                6/50 (12%)      | 
|POLY-3 RATE (b)    |                  0/38.18                  3/40.28                  2/37.40                  6/40.41         | 
|POLY-3 PERCENT (g) |                  0.0%                     7.5%                     5.4%                     14.9%           | 
|TERMINAL (d)       |                  0/22 (0%)                2/28 (7%)                2/24 (8%)                3/27 (11%)      | 
|FIRST INCIDENCE    |                  ---                      491                      729 (T)                  632             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.030 *                P=0.157                  P=0.257                  P=0.028 *       | 
|POLY 3             |                  P=0.022 *                P=0.128                  P=0.232                  P=0.018 *       | 
|POLY 1.5           |                  P=0.020 *                P=0.122                  P=0.232                  P=0.016 *       | 
|POLY 6             |                  P=0.026 *                P=0.134                  P=0.233                  P=0.021 *       | 
|LOGISTIC REGRESSION|                  P=0.023 *                P=0.110                  P=0.257                  P=0.020 *       | 
|COCH-ARM / FISHERS |                  P=0.017 *                P=0.111                  P=0.248                  P=0.011 *       | 
|ORDER RESTRICTED   |                  P=0.006 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  23/53 (43%)              5/50 (10%)               5/53 (9%)                8/50 (16%)      | 
|POLY-3 RATE (b)    |                  23/41.69                 5/39.59                  5/38.38                  8/41.69         | 
|POLY-3 PERCENT (g) |                  55.2%                    12.6%                    13.0%                    19.2%           | 
|TERMINAL (d)       |                  15/22 (68%)              5/28 (18%)               2/24 (8%)                4/27 (15%)      | 
|FIRST INCIDENCE    |                  345                      729 (T)                  505                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.109N                 P<0.001N**               P<0.001N**               P<0.001N**      | 
|POLY 3             |                  P=0.088N                 P<0.001N**               P<0.001N**               P<0.001N**      | 
|POLY 1.5           |                  P=0.111N                 P<0.001N**               P<0.001N**               P<0.001N**      | 
|POLY 6             |                  P=0.067N                 P<0.001N**               P<0.001N**               P<0.001N**      | 
|LOGISTIC REGRESSION|                  P=0.138N                 P<0.001N**               P<0.001N**               P<0.001N**      | 
|COCH-ARM / FISHERS |                  P=0.173N                 P<0.001N**               P<0.001N**               P=0.002N**      | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                39/50 (78%)              34/53 (64%)              30/50 (60%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  39/45.77                 34/41.55                 30/42.62        | 
|POLY-3 PERCENT (g) |                  0.0%                     85.2%                    81.8%                    70.4%           | 
|TERMINAL (d)       |                  0/22 (0%)                25/28 (89%)              23/24 (96%)              22/27 (82%)     | 
|FIRST INCIDENCE    |                  ---                      478                      505                      491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.121                  P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P=0.030 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P=0.017 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P=0.061                  P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P=0.049 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P=0.025 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/49 (0%)                3/50 (6%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/39.12                  3/35.88                  2/38.99         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     8.4%                     5.1%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                2/24 (8%)                2/27 (7%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      603                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.346                  (e)                      P=0.131                  P=0.284         | 
|POLY 3             |                  P=0.318                  (e)                      P=0.106                  P=0.241         | 
|POLY 1.5           |                  P=0.311                  (e)                      P=0.105                  P=0.234         | 
|POLY 6             |                  P=0.329                  (e)                      P=0.111                  P=0.250         | 
|LOGISTIC REGRESSION|                  P=0.336                  (e)                      P=0.108                  P=0.284         | 
|COCH-ARM / FISHERS |                  P=0.304                  (e)                      P=0.111                  P=0.228         | 
|ORDER RESTRICTED   |                  P=0.071                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  37/53 (70%)              33/49 (67%)              36/50 (72%)              32/49 (65%)     | 
|POLY-3 RATE (b)    |                  37/46.61                 33/44.17                 36/42.27                 32/44.54        | 
|POLY-3 PERCENT (g) |                  79.4%                    74.7%                    85.2%                    71.9%           | 
|TERMINAL (d)       |                  18/22 (82%)              22/28 (79%)              23/24 (96%)              20/27 (74%)     | 
|FIRST INCIDENCE    |                  418                      441                      363                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.141N                 P=0.091N                 P=0.399N                 P=0.080N        | 
|POLY 3             |                  P=0.189N                 P=0.382N                 P=0.317                  P=0.263N        | 
|POLY 1.5           |                  P=0.223N                 P=0.386N                 P=0.346                  P=0.287N        | 
|POLY 6             |                  P=0.161N                 P=0.398N                 P=0.312                  P=0.246N        | 
|LOGISTIC REGRESSION|                  P=0.235N                 P=0.321N                 P=0.403                  P=0.295N        | 
|COCH-ARM / FISHERS |                  P=0.350N                 P=0.478N                 P=0.489                  P=0.392N        | 
|ORDER RESTRICTED   |                  P=0.259N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                0/49 (0%)                2/50 (4%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  1/38.18                  0/39.12                  2/36.99                  2/39.96         | 
|POLY-3 PERCENT (g) |                  2.6%                     0.0%                     5.4%                     5.0%            | 
|TERMINAL (d)       |                  1/22 (5%)                0/28 (0%)                0/24 (0%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      363                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.377                  P=0.452N                 P=0.508                  P=0.545         | 
|POLY 3             |                  P=0.367                  P=0.495N                 P=0.489                  P=0.516         | 
|POLY 1.5           |                  P=0.359                  P=0.501N                 P=0.481                  P=0.502         | 
|POLY 6             |                  P=0.376                  P=0.489N                 P=0.502                  P=0.531         | 
|LOGISTIC REGRESSION|                  P=0.267                  (e)                      P=0.508                  P=0.414         | 
|COCH-ARM / FISHERS |                  P=0.344                  P=0.520N                 P=0.478                  P=0.470         | 
|ORDER RESTRICTED   |                  P=0.260                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                1/49 (2%)                1/52 (2%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  1/38.87                  1/38.06                  2/38.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.6%                     2.6%                     5.2%            | 
|TERMINAL (d)       |                  0/22 (0%)                1/28 (4%)                0/24 (0%)                2/27 (7%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  506                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.279                  P=0.548                  P=0.500                  P=0.284         | 
|POLY 3             |                  P=0.254                  P=0.504                  P=0.499                  P=0.238         | 
|POLY 1.5           |                  P=0.248                  P=0.498                  P=0.497                  P=0.232         | 
|POLY 6             |                  P=0.261                  P=0.510                  P=0.503                  P=0.245         | 
|LOGISTIC REGRESSION|                  P=0.247                  P=0.548                  P=0.501                  P=0.284         | 
|COCH-ARM / FISHERS |                  P=0.237                  P=0.480                  P=0.495                  P=0.228         | 
|ORDER RESTRICTED   |                  P=0.118                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/4 (100%)               0/2 (0%)                 1/7 (14%)                1/5 (20%)       | 
|POLY-3 RATE (b)    |                  4/4.00                   0/1.26                   1/4.32                   1/4.56          | 
|POLY-3 PERCENT (g) |                  100.0%                   0.0%                     23.2%                    21.9%           | 
|TERMINAL (d)       |                  1/1 (100%)               0/1 (0%)                 0/2 (0%)                 1/4 (25%)       | 
|FIRST INCIDENCE    |                  449                      ---                      552                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.260N                 P=0.057N                 P=0.143N                 P=0.047N*       | 
|POLY 3             |                  P=0.066N                 P=0.027N*                P=0.009N**               P=0.009N**      | 
|POLY 1.5           |                  P=0.114N                 P<0.001N**               P=0.002N**               P=0.007N**      | 
|POLY 6             |                  P=0.046N*                P=0.137N                 P=0.043N*                P=0.014N*       | 
|LOGISTIC REGRESSION|                  P=0.376N                 P=0.065N                 P=0.017N*                P=0.110N        | 
|COCH-ARM / FISHERS |                  P=0.330N                 P=0.067N                 P=0.015N*                P=0.040N*       | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/4 (100%)               0/2 (0%)                 0/7 (0%)                 0/5 (0%)        | 
|POLY-3 RATE (b)    |                  4/4.00                   0/1.26                   0/3.75                   0/4.56          | 
|POLY-3 PERCENT (g) |                  100.0%                   0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/1 (100%)               0/1 (0%)                 0/2 (0%)                 0/4 (0%)        | 
|FIRST INCIDENCE    |                  449                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.136N                 P=0.057N                 P=0.044N*                P=0.025N*       | 
|POLY 3             |                  P<0.001N**               P=0.027N*                P<0.001N**               P<0.001N**      | 
|POLY 1.5           |                  P<0.001N**               P<0.001N**               P<0.001N**               P<0.001N**      | 
|POLY 6             |                  P<0.001N**               P=0.137N                 P<0.001N**               P<0.001N**      | 
|LOGISTIC REGRESSION|                  P=0.165N                 P=0.065N                 P=0.004N**               P=0.038N*       | 
|COCH-ARM / FISHERS |                  P=0.133N                 P=0.067N                 P=0.003N**               P=0.008N**      | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/4 (0%)                 0/2 (0%)                 0/7 (0%)                 2/5 (40%)       | 
|POLY-3 RATE (b)    |                  0/2.13                   0/1.26                   0/3.75                   2/4.56          | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     43.9%           | 
|TERMINAL (d)       |                  0/1 (0%)                 0/1 (0%)                 0/2 (0%)                 2/4 (50%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.213                  (e)                      (e)                      P=0.581         | 
|POLY 3             |                  P=0.097                  (e)                      (e)                      P=0.412         | 
|POLY 1.5           |                  P=0.068                  (e)                      (e)                      P=0.349         | 
|POLY 6             |                  P=0.140                  (e)                      (e)                      P=0.482         | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      P=0.581         | 
|COCH-ARM / FISHERS |                  P=0.054                  (e)                      (e)                      P=0.278         | 
|ORDER RESTRICTED   |                  P=0.130                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/4 (0%)                 0/2 (0%)                 1/7 (14%)                2/5 (40%)       | 
|POLY-3 RATE (b)    |                  0/2.13                   0/1.26                   1/4.66                   2/4.56          | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     21.5%                    43.9%           | 
|TERMINAL (d)       |                  0/1 (0%)                 0/1 (0%)                 0/2 (0%)                 2/4 (50%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      330                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.341                  (e)                      P=0.500                  P=0.581         | 
|POLY 3             |                  P=0.275                  (e)                      P=0.653                  P=0.412         | 
|POLY 1.5           |                  P=0.220                  (e)                      P=0.635                  P=0.349         | 
|POLY 6             |                  P=0.346                  (e)                      P=0.673                  P=0.482         | 
|LOGISTIC REGRESSION|                  P=0.102                  (e)                      (e)                      P=0.581         | 
|COCH-ARM / FISHERS |                  P=0.152                  (e)                      P=0.636                  P=0.278         | 
|ORDER RESTRICTED   |                  P=0.210                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/4 (0%)                 0/2 (0%)                 2/7 (29%)                0/5 (0%)        | 
|POLY-3 RATE (b)    |                  0/2.13                   0/1.26                   2/4.81                   0/4.56          | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     41.6%                    0.0%            | 
|TERMINAL (d)       |                  0/1 (0%)                 0/1 (0%)                 0/2 (0%)                 0/4 (0%)        | 
|FIRST INCIDENCE    |                  ---                      ---                      506                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.549N                 (e)                      P=0.227                  (e)             | 
|POLY 3             |                  P=0.358N                 (e)                      P=0.422                  (e)             | 
|POLY 1.5           |                  P=0.419N                 (e)                      P=0.386                  (e)             | 
|POLY 6             |                  P=0.302N                 (e)                      P=0.478                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.624N                 (e)                      P=0.356                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.507N                 (e)                      P=0.382                  (e)             | 
|ORDER RESTRICTED   |                  P=0.357N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                2/50 (4%)                3/53 (6%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  3/39.88                  2/40.31                  3/38.06                  2/40.45         | 
|POLY-3 PERCENT (g) |                  7.5%                     5.0%                     7.9%                     4.9%            | 
|TERMINAL (d)       |                  1/22 (5%)                1/28 (4%)                2/24 (8%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  345                      478                      506                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.460N                 P=0.451N                 P=0.650N                 P=0.453N        | 
|POLY 3             |                  P=0.486N                 P=0.495N                 P=0.642                  P=0.493N        | 
|POLY 1.5           |                  P=0.492N                 P=0.504N                 P=0.644                  P=0.502N        | 
|POLY 6             |                  P=0.478N                 P=0.486N                 P=0.646                  P=0.482N        | 
|LOGISTIC REGRESSION|                  P=0.534N                 P=0.676N                 P=0.649N                 P=0.587N        | 
|COCH-ARM / FISHERS |                  P=0.505N                 P=0.528N                 P=0.661N                 P=0.518N        | 
|ORDER RESTRICTED   |                  P=0.499N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  29/53 (55%)              14/50 (28%)              22/53 (42%)              15/51 (29%)     | 
|POLY-3 RATE (b)    |                  29/44.60                 14/42.77                 22/41.66                 15/42.12        | 
|POLY-3 PERCENT (g) |                  65.0%                    32.7%                    52.8%                    35.6%           | 
|TERMINAL (d)       |                  16/22 (73%)              7/28 (25%)               11/24 (46%)              10/27 (37%)     | 
|FIRST INCIDENCE    |                  418                      462                      499                      463             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.045N*                P<0.001N**               P=0.117N                 P=0.002N**      | 
|POLY 3             |                  P=0.052N                 P<0.001N**               P=0.164N                 P=0.003N**      | 
|POLY 1.5           |                  P=0.053N                 P=0.002N**               P=0.157N                 P=0.004N**      | 
|POLY 6             |                  P=0.055N                 P<0.001N**               P=0.154N                 P=0.003N**      | 
|LOGISTIC REGRESSION|                  P=0.051N                 P=0.004N**               P=0.134N                 P=0.004N**      | 
|COCH-ARM / FISHERS |                  P=0.069N                 P=0.005N**               P=0.122N                 P=0.008N**      | 
|ORDER RESTRICTED   |                  P=0.002N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/53 (9%)                2/50 (4%)                3/53 (6%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  5/39.94                  2/40.28                  3/37.73                  0/39.98         | 
|POLY-3 PERCENT (g) |                  12.5%                    5.0%                     8.0%                     0.0%            | 
|TERMINAL (d)       |                  2/22 (9%)                1/28 (4%)                1/24 (4%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  345                      491                      650                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.054N                 P=0.173N                 P=0.345N                 P=0.027N*       | 
|POLY 3             |                  P=0.054N                 P=0.210N                 P=0.387N                 P=0.030N*       | 
|POLY 1.5           |                  P=0.055N                 P=0.219N                 P=0.382N                 P=0.031N*       | 
|POLY 6             |                  P=0.053N                 P=0.201N                 P=0.384N                 P=0.028N*       | 
|LOGISTIC REGRESSION|                  P=0.061N                 P=0.298N                 P=0.359N                 P=0.044N*       | 
|COCH-ARM / FISHERS |                  P=0.060N                 P=0.243N                 P=0.358N                 P=0.031N*       | 
|ORDER RESTRICTED   |                  P=0.013N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/47 (2%)                1/31 (3%)                2/47 (4%)                1/47 (2%)       | 
|POLY-3 RATE (b)    |                  1/34.51                  1/23.96                  2/33.24                  1/36.01         | 
|POLY-3 PERCENT (g) |                  2.9%                     4.2%                     6.0%                     2.8%            | 
|TERMINAL (d)       |                  0/19 (0%)                1/17 (6%)                2/21 (10%)               0/23 (0%)       | 
|FIRST INCIDENCE    |                  688                      729 (T)                  729 (T)                  720             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.547N                 P=0.760                  P=0.528                  P=0.717N        | 
|POLY 3             |                  P=0.547N                 P=0.679                  P=0.487                  P=0.752N        | 
|POLY 1.5           |                  P=0.553N                 P=0.674                  P=0.487                  P=0.756N        | 
|POLY 6             |                  P=0.542N                 P=0.685                  P=0.491                  P=0.748N        | 
|LOGISTIC REGRESSION|                  P=0.540N                 P=0.690                  P=0.503                  P=0.748N        | 
|COCH-ARM / FISHERS |                  P=0.564N                 P=0.640                  P=0.500                  P=0.753N        | 
|ORDER RESTRICTED   |                  P=0.563N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  22/53 (42%)              17/50 (34%)              13/53 (25%)              15/51 (29%)     | 
|POLY-3 RATE (b)    |                  22/43.64                 17/43.73                 13/40.22                 15/41.65        | 
|POLY-3 PERCENT (g) |                  50.4%                    38.9%                    32.3%                    36.0%           | 
|TERMINAL (d)       |                  10/22 (46%)              9/28 (32%)               5/24 (21%)               10/27 (37%)     | 
|FIRST INCIDENCE    |                  418                      441                      539                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.216N                 P=0.124N                 P=0.067N                 P=0.059N        | 
|POLY 3             |                  P=0.295N                 P=0.186N                 P=0.067N                 P=0.124N        | 
|POLY 1.5           |                  P=0.285N                 P=0.205N                 P=0.062N                 P=0.121N        | 
|POLY 6             |                  P=0.317N                 P=0.181N                 P=0.069N                 P=0.135N        | 
|LOGISTIC REGRESSION|                  P=0.265N                 P=0.268N                 P=0.053N                 P=0.102N        | 
|COCH-ARM / FISHERS |                  P=0.302N                 P=0.281N                 P=0.049N*                P=0.139N        | 
|ORDER RESTRICTED   |                  P=0.087N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/53 (8%)                5/50 (10%)               6/53 (11%)               5/51 (10%)      | 
|POLY-3 RATE (b)    |                  4/38.51                  5/41.00                  6/38.67                  5/41.38         | 
|POLY-3 PERCENT (g) |                  10.4%                    12.2%                    15.5%                    12.1%           | 
|TERMINAL (d)       |                  2/22 (9%)                3/28 (11%)               1/24 (4%)                2/27 (7%)       | 
|FIRST INCIDENCE    |                  664                      478                      603                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.572N                 P=0.597                  P=0.388                  P=0.569         | 
|POLY 3             |                  P=0.584N                 P=0.540                  P=0.370                  P=0.545         | 
|POLY 1.5           |                  P=0.601                  P=0.516                  P=0.361                  P=0.521         | 
|POLY 6             |                  P=0.566N                 P=0.561                  P=0.389                  P=0.572         | 
|LOGISTIC REGRESSION|                  P=0.582                  P=0.492                  P=0.357                  P=0.506         | 
|COCH-ARM / FISHERS |                  P=0.564                  P=0.463                  P=0.371                  P=0.475         | 
|ORDER RESTRICTED   |                  P=0.512                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  10/53 (19%)              14/50 (28%)              11/53 (21%)              12/51 (24%)     | 
|POLY-3 RATE (b)    |                  10/39.82                 14/43.24                 11/40.12                 12/41.65        | 
|POLY-3 PERCENT (g) |                  25.1%                    32.4%                    27.4%                    28.8%           | 
|TERMINAL (d)       |                  6/22 (27%)               7/28 (25%)               3/24 (13%)               7/27 (26%)      | 
|FIRST INCIDENCE    |                  418                      441                      539                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.520N                 P=0.388                  P=0.529                  P=0.559         | 
|POLY 3             |                  P=0.563                  P=0.312                  P=0.508                  P=0.449         | 
|POLY 1.5           |                  P=0.550                  P=0.269                  P=0.489                  P=0.420         | 
|POLY 6             |                  P=0.571                  P=0.362                  P=0.549                  P=0.485         | 
|LOGISTIC REGRESSION|                  P=0.544                  P=0.214                  P=0.481                  P=0.434         | 
|COCH-ARM / FISHERS |                  P=0.507                  P=0.194                  P=0.500                  P=0.366         | 
|ORDER RESTRICTED   |                  P=0.514                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/12 (67%)               21/28 (75%)              22/30 (73%)              29/41 (71%)     | 
|POLY-3 RATE (b)    |                  8/11.04                  21/26.86                 22/27.81                 29/38.96        | 
|POLY-3 PERCENT (g) |                  72.5%                    78.2%                    79.1%                    74.4%           | 
|TERMINAL (d)       |                  2/3 (67%)                10/15 (67%)              12/15 (80%)              17/24 (71%)     | 
|FIRST INCIDENCE    |                  451                      491                      451                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.333                  P=0.193                  P=0.184                  P=0.160         | 
|POLY 3             |                  P=0.449N                 P=0.518                  P=0.491                  P=0.604         | 
|POLY 1.5           |                  P=0.466N                 P=0.478                  P=0.480                  P=0.571         | 
|POLY 6             |                  P=0.438N                 P=0.589                  P=0.525                  P=0.655         | 
|LOGISTIC REGRESSION|                  P=0.493N                 P=0.431                  P=0.491                  P=0.526         | 
|COCH-ARM / FISHERS |                  P=0.494N                 P=0.430                  P=0.469                  P=0.524         | 
|ORDER RESTRICTED   |                  P=0.638                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  45/53 (85%)              46/48 (96%)              43/52 (83%)              36/50 (72%)     | 
|POLY-3 RATE (b)    |                  45/49.16                 46/47.26                 43/48.11                 36/46.64        | 
|POLY-3 PERCENT (g) |                  91.5%                    97.4%                    89.4%                    77.2%           | 
|TERMINAL (d)       |                  21/22 (96%)              27/28 (96%)              22/24 (92%)              21/27 (78%)     | 
|FIRST INCIDENCE    |                  345                      441                      254                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.022N*                P=0.255N                 P=0.363N                 P=0.025N*       | 
|POLY 3             |                  P<0.001N**               P=0.179                  P=0.493N                 P=0.033N*       | 
|POLY 1.5           |                  P<0.001N**               P=0.124                  P=0.480N                 P=0.040N*       | 
|POLY 6             |                  P<0.001N**               P=0.313                  P=0.514N                 P=0.031N*       | 
|LOGISTIC REGRESSION|                  P=0.004N**               P=0.130                  P=0.499N                 P=0.065N        | 
|COCH-ARM / FISHERS |                  P=0.008N**               P=0.064                  P=0.483N                 P=0.087N        | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  14/53 (26%)              16/48 (33%)              14/52 (27%)              19/50 (38%)     | 
|POLY-3 RATE (b)    |                  14/40.50                 16/41.13                 14/39.03                 19/42.91        | 
|POLY-3 PERCENT (g) |                  34.6%                    38.9%                    35.9%                    44.3%           | 
|TERMINAL (d)       |                  8/22 (36%)               10/28 (36%)              11/24 (46%)              12/27 (44%)     | 
|FIRST INCIDENCE    |                  451                      484                      330                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.272                  P=0.546N                 P=0.519N                 P=0.380         | 
|POLY 3             |                  P=0.226                  P=0.429                  P=0.546                  P=0.243         | 
|POLY 1.5           |                  P=0.194                  P=0.383                  P=0.554                  P=0.204         | 
|POLY 6             |                  P=0.265                  P=0.482                  P=0.532                  P=0.290         | 
|LOGISTIC REGRESSION|                  P=0.175                  P=0.369                  P=0.563                  P=0.183         | 
|COCH-ARM / FISHERS |                  P=0.147                  P=0.294                  P=0.564                  P=0.147         | 
|ORDER RESTRICTED   |                  P=0.276                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                0/48 (0%)                0/52 (0%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  1/38.95                  0/38.21                  0/37.39                  4/39.49         | 
|POLY-3 PERCENT (g) |                  2.6%                     0.0%                     0.0%                     10.1%           | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                3/27 (11%)      | 
|FIRST INCIDENCE    |                  451                      ---                      ---                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.015 *                P=0.492N                 P=0.500N                 P=0.234         | 
|POLY 3             |                  P=0.009 **               P=0.504N                 P=0.508N                 P=0.181         | 
|POLY 1.5           |                  P=0.009 **               P=0.508N                 P=0.507N                 P=0.175         | 
|POLY 6             |                  P=0.009 **               P=0.499N                 P=0.508N                 P=0.189         | 
|LOGISTIC REGRESSION|                  P=0.009 **               P=0.666N                 P=0.498N                 P=0.163         | 
|COCH-ARM / FISHERS |                  P=0.009 **               P=0.525N                 P=0.505N                 P=0.164         | 
|ORDER RESTRICTED   |                  P=0.012 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/1 (100%)               0/1 (0%)                 2/2 (100%)               0/3 (0%)        | 
|POLY-3 RATE (b)    |                  1/1.00                   0/1.00                   2/2.00                   0/2.94          | 
|POLY-3 PERCENT (g) |                  100.0%                   0.0%                     100.0%                   0.0%            | 
|TERMINAL (d)       |                  1/1 (100%)               0/1 (0%)                 0/0 (0%)                 0/2 (0%)        | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      539                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.281N                 P=0.500N                 (e)                      P=0.362N        | 
|POLY 3             |                  P<0.001N**               P=1.000                  (e)                      P<0.001N**      | 
|POLY 1.5           |                  P<0.001N**               P=1.000N                 (e)                      P<0.001N**      | 
|POLY 6             |                  P<0.001N**               P=1.000                  (e)                      P<0.001N**      | 
|LOGISTIC REGRESSION|                  P=0.281N                 P=0.250N                 (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.500N                 (e)                      P=0.250N        | 
|ORDER RESTRICTED   |                  P=0.025N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/1 (0%)                 0/1 (0%)                 0/2 (0%)                 3/3 (100%)      | 
|POLY-3 RATE (b)    |                  0/1.00                   0/1.00                   0/1.14                   3/3.00          | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     100.0%          | 
|TERMINAL (d)       |                  0/1 (0%)                 0/1 (0%)                 0/0 (0%)                 2/2 (100%)      | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      714             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.042 *                (e)                      (e)                      P=0.188         | 
|POLY 3             |                  P<0.001 **               (e)                      (e)                      P=0.250         | 
|POLY 1.5           |                  P<0.001 **               (e)                      (e)                      P=0.250         | 
|POLY 6             |                  P<0.001 **               (e)                      (e)                      P=0.250         | 
|LOGISTIC REGRESSION|                  P=0.062                  (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.028 *                (e)                      (e)                      P=0.250         | 
|ORDER RESTRICTED   |                  P=0.008 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                5/49 (10%)               1/52 (2%)                5/49 (10%)      | 
|POLY-3 RATE (b)    |                  0/38.18                  5/40.27                  1/37.39                  5/38.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     12.4%                    2.7%                     13.0%           | 
|TERMINAL (d)       |                  0/22 (0%)                2/28 (7%)                1/24 (4%)                4/27 (15%)      | 
|FIRST INCIDENCE    |                  ---                      491                      729 (T)                  668             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.129                  P=0.047 *                P=0.517                  P=0.052         | 
|POLY 3             |                  P=0.105                  P=0.034 *                P=0.496                  P=0.030 *       | 
|POLY 1.5           |                  P=0.099                  P=0.031 *                P=0.495                  P=0.028 *       | 
|POLY 6             |                  P=0.113                  P=0.039 *                P=0.498                  P=0.032 *       | 
|LOGISTIC REGRESSION|                  P=0.100                  P=0.026 *                P=0.517                  P=0.036 *       | 
|COCH-ARM / FISHERS |                  P=0.088                  P=0.023 *                P=0.495                  P=0.023 *       | 
|ORDER RESTRICTED   |                  P=0.016 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                4/49 (8%)                1/52 (2%)                5/49 (10%)      | 
|POLY-3 RATE (b)    |                  0/38.18                  4/40.03                  1/37.39                  5/38.23         | 
|POLY-3 PERCENT (g) |                  0.0%                     10.0%                    2.7%                     13.1%           | 
|TERMINAL (d)       |                  0/22 (0%)                2/28 (7%)                1/24 (4%)                5/27 (19%)      | 
|FIRST INCIDENCE    |                  ---                      491                      729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.081                  P=0.087                  P=0.517                  P=0.051         | 
|POLY 3             |                  P=0.063                  P=0.066                  P=0.496                  P=0.029 *       | 
|POLY 1.5           |                  P=0.060                  P=0.061                  P=0.495                  P=0.028 *       | 
|POLY 6             |                  P=0.066                  P=0.072                  P=0.498                  P=0.031 *       | 
|LOGISTIC REGRESSION|                  P=0.064                  P=0.050                  P=0.517                  P=0.051         | 
|COCH-ARM / FISHERS |                  P=0.054                  P=0.050                  P=0.495                  P=0.023 *       | 
|ORDER RESTRICTED   |                  P=0.012 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                0/49 (0%)                1/52 (2%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  2/38.18                  0/38.93                  1/37.39                  1/38.68         | 
|POLY-3 PERCENT (g) |                  5.2%                     0.0%                     2.7%                     2.6%            | 
|TERMINAL (d)       |                  2/22 (9%)                0/28 (0%)                1/24 (4%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      729 (T)                  596             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.664N                 P=0.186N                 P=0.469N                 P=0.444N        | 
|POLY 3             |                  P=0.703N                 P=0.232N                 P=0.507N                 P=0.495N        | 
|POLY 1.5           |                  P=0.706N                 P=0.239N                 P=0.509N                 P=0.507N        | 
|POLY 6             |                  P=0.700N                 P=0.225N                 P=0.504N                 P=0.482N        | 
|LOGISTIC REGRESSION|                  P=0.692N                 (e)                      P=0.469N                 P=0.503N        | 
|COCH-ARM / FISHERS |                  P=0.710N                 P=0.268N                 P=0.507N                 P=0.530N        | 
|ORDER RESTRICTED   |                  P=0.268N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                3/49 (6%)                7/52 (13%)               44/49 (90%)     | 
|POLY-3 RATE (b)    |                  0/38.18                  3/39.04                  7/38.39                  44/45.45        | 
|POLY-3 PERCENT (g) |                  0.0%                     7.7%                     18.2%                    96.8%           | 
|TERMINAL (d)       |                  0/22 (0%)                2/28 (7%)                5/24 (21%)               27/27 (100%)    | 
|FIRST INCIDENCE    |                  ---                      701                      552                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.162                  P=0.012 *                P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P=0.122                  P=0.007 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P=0.117                  P=0.007 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P=0.127                  P=0.008 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.135                  P=0.008 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.107                  P=0.006 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                4/49 (8%)                2/52 (4%)                3/49 (6%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  4/39.04                  2/38.06                  3/38.67         | 
|POLY-3 PERCENT (g) |                  0.0%                     10.3%                    5.3%                     7.8%            | 
|TERMINAL (d)       |                  0/22 (0%)                3/28 (11%)               1/24 (4%)                2/27 (7%)       | 
|FIRST INCIDENCE    |                  ---                      701                      506                      601             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.437                  P=0.095                  P=0.249                  P=0.151         | 
|POLY 3             |                  P=0.410                  P=0.062                  P=0.236                  P=0.120         | 
|POLY 1.5           |                  P=0.395                  P=0.059                  P=0.234                  P=0.115         | 
|POLY 6             |                  P=0.428                  P=0.066                  P=0.240                  P=0.127         | 
|LOGISTIC REGRESSION|                  P=0.390                  P=0.074                  P=0.234                  P=0.119         | 
|COCH-ARM / FISHERS |                  P=0.367                  P=0.050                  P=0.243                  P=0.107         | 
|ORDER RESTRICTED   |                  P=0.109                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  17/53 (32%)              14/50 (28%)              17/52 (33%)              7/51 (14%)      | 
|POLY-3 RATE (b)    |                  17/40.84                 14/41.76                 17/39.38                 7/40.52         | 
|POLY-3 PERCENT (g) |                  41.6%                    33.5%                    43.2%                    17.3%           | 
|TERMINAL (d)       |                  11/22 (50%)              8/28 (29%)               9/24 (38%)               5/27 (19%)      | 
|FIRST INCIDENCE    |                  418                      491                      506                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.008N**               P=0.184N                 P=0.518N                 P=0.006N**      | 
|POLY 3             |                  P=0.008N**               P=0.293N                 P=0.535                  P=0.012N*       | 
|POLY 1.5           |                  P=0.009N**               P=0.328N                 P=0.521                  P=0.014N*       | 
|POLY 6             |                  P=0.008N**               P=0.253N                 P=0.581                  P=0.010N*       | 
|LOGISTIC REGRESSION|                  P=0.008N**               P=0.311N                 P=0.531                  P=0.012N*       | 
|COCH-ARM / FISHERS |                  P=0.013N*                P=0.407N                 P=0.556                  P=0.023N*       | 
|ORDER RESTRICTED   |                  P=0.011N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                1/50 (2%)                0/52 (0%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  1/40.20                  0/36.79                  2/39.98         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.5%                     0.0%                     5.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                2/27 (7%)       | 
|FIRST INCIDENCE    |                  ---                      534                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.172                  P=0.510                  (e)                      P=0.284         | 
|POLY 3             |                  P=0.163                  P=0.510                  (e)                      P=0.247         | 
|POLY 1.5           |                  P=0.159                  P=0.503                  (e)                      P=0.241         | 
|POLY 6             |                  P=0.167                  P=0.517                  (e)                      P=0.254         | 
|LOGISTIC REGRESSION|                  P=0.155                  P=0.414                  (e)                      P=0.284         | 
|COCH-ARM / FISHERS |                  P=0.149                  P=0.485                  (e)                      P=0.238         | 
|ORDER RESTRICTED   |                  P=0.080                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/50 (0%)                1/52 (2%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/39.59                  1/36.79                  2/40.04         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     2.7%                     5.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                1/24 (4%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      729 (T)                  714             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.155                  (e)                      P=0.517                  P=0.284         | 
|POLY 3             |                  P=0.134                  (e)                      P=0.493                  P=0.247         | 
|POLY 1.5           |                  P=0.132                  (e)                      P=0.492                  P=0.241         | 
|POLY 6             |                  P=0.137                  (e)                      P=0.496                  P=0.254         | 
|LOGISTIC REGRESSION|                  P=0.149                  (e)                      P=0.517                  P=0.264         | 
|COCH-ARM / FISHERS |                  P=0.128                  (e)                      P=0.495                  P=0.238         | 
|ORDER RESTRICTED   |                  P=0.080                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  13/53 (25%)              17/50 (34%)              20/52 (38%)              21/51 (41%)     | 
|POLY-3 RATE (b)    |                  13/41.27                 17/42.72                 20/40.07                 21/42.87        | 
|POLY-3 PERCENT (g) |                  31.5%                    39.8%                    49.9%                    49.0%           | 
|TERMINAL (d)       |                  6/22 (27%)               11/28 (39%)              11/24 (46%)              15/27 (56%)     | 
|FIRST INCIDENCE    |                  451                      484                      505                      458             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.243                  P=0.431                  P=0.148                  P=0.177         | 
|POLY 3             |                  P=0.159                  P=0.283                  P=0.065                  P=0.072         | 
|POLY 1.5           |                  P=0.153                  P=0.259                  P=0.066                  P=0.067         | 
|POLY 6             |                  P=0.155                  P=0.303                  P=0.072                  P=0.074         | 
|LOGISTIC REGRESSION|                  P=0.168                  P=0.238                  P=0.077                  P=0.075         | 
|COCH-ARM / FISHERS |                  P=0.131                  P=0.200                  P=0.092                  P=0.055         | 
|ORDER RESTRICTED   |                  P=0.062                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/50 (0%)                0/53 (0%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/39.59                  0/37.40                  2/41.69         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.8%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.048 *                (e)                      (e)                      P=0.245         | 
|POLY 3             |                  P=0.049 *                (e)                      (e)                      P=0.257         | 
|POLY 1.5           |                  P=0.047 *                (e)                      (e)                      P=0.248         | 
|POLY 6             |                  P=0.051                  (e)                      (e)                      P=0.267         | 
|LOGISTIC REGRESSION|                  P=0.008 **               (e)                      (e)                      P=0.088         | 
|COCH-ARM / FISHERS |                  P=0.044 *                (e)                      (e)                      P=0.238         | 
|ORDER RESTRICTED   |                  P=0.036 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  51/53 (96%)              41/49 (84%)              47/52 (90%)              45/49 (92%)     | 
|POLY-3 RATE (b)    |                  51/51.98                 41/45.57                 47/50.21                 45/46.44        | 
|POLY-3 PERCENT (g) |                  98.1%                    90.0%                    93.6%                    96.9%           | 
|TERMINAL (d)       |                  22/22 (100%)             28/28 (100%)             24/24 (100%)             27/27 (100%)    | 
|FIRST INCIDENCE    |                  85                       441                      142                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.221N                 P=0.008N**               P=0.267N                 P=0.051N        | 
|POLY 3             |                  P=0.354                  P=0.050N                 P=0.228N                 P=0.633N        | 
|POLY 1.5           |                  P=0.383                  P=0.036N*                P=0.215N                 P=0.481N        | 
|POLY 6             |                  P=0.354                  P=0.122N                 P=0.263N                 P=0.870N        | 
|LOGISTIC REGRESSION|                  P=0.558                  P=0.016N*                P=0.212N                 P=0.189N        | 
|COCH-ARM / FISHERS |                  P=0.498                  P=0.035N*                P=0.211N                 P=0.302N        | 
|ORDER RESTRICTED   |                  P=0.160N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  47/53 (89%)              48/49 (98%)              51/52 (98%)              49/49 (100%)    | 
|POLY-3 RATE (b)    |                  47/50.25                 48/48.68                 51/51.01                 49/49.00        | 
|POLY-3 PERCENT (g) |                  93.5%                    98.6%                    100.0%                   100.0%          | 
|TERMINAL (d)       |                  21/22 (96%)              28/28 (100%)             24/24 (100%)             27/27 (100%)    | 
|FIRST INCIDENCE    |                  85                       441                      254                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.362N                 P=0.250N                 P=0.417                  P=0.332N        | 
|POLY 3             |                  P=0.174                  P=0.170                  P=0.055                  P=0.060         | 
|POLY 1.5           |                  P=0.115                  P=0.111                  P=0.033 *                P=0.033 *       | 
|POLY 6             |                  P=0.319                  P=0.302                  P=0.156                  P=0.165         | 
|LOGISTIC REGRESSION|                  P=0.089                  P=0.097                  P=0.053                  P=0.028 *       | 
|COCH-ARM / FISHERS |                  P=0.078                  P=0.069                  P=0.059                  P=0.017 *       | 
|ORDER RESTRICTED   |                  P=0.002 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                5/49 (10%)               4/52 (8%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  5/40.77                  4/38.83                  2/39.64         | 
|POLY-3 PERCENT (g) |                  0.0%                     12.3%                    10.3%                    5.1%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      567                      310                      233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.454N                 P=0.036 *                P=0.068                  P=0.243         | 
|POLY 3             |                  P=0.435N                 P=0.036 *                P=0.061                  P=0.245         | 
|POLY 1.5           |                  P=0.454N                 P=0.031 *                P=0.060                  P=0.237         | 
|POLY 6             |                  P=0.417N                 P=0.042 *                P=0.064                  P=0.255         | 
|LOGISTIC REGRESSION|                  P=0.540N                 P=0.021 *                P=0.061                  P=0.118         | 
|COCH-ARM / FISHERS |                  P=0.497N                 P=0.023 *                P=0.057                  P=0.228         | 
|ORDER RESTRICTED   |                  P=0.082                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/50 (0%)                2/52 (4%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/39.59                  2/37.84                  2/40.33         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     5.3%                     5.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      612                      632             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.247                  (e)                      P=0.239                  P=0.259         | 
|POLY 3             |                  P=0.234                  (e)                      P=0.234                  P=0.249         | 
|POLY 1.5           |                  P=0.229                  (e)                      P=0.233                  P=0.242         | 
|POLY 6             |                  P=0.242                  (e)                      P=0.239                  P=0.258         | 
|LOGISTIC REGRESSION|                  P=0.233                  (e)                      P=0.233                  P=0.243         | 
|COCH-ARM / FISHERS |                  P=0.222                  (e)                      P=0.243                  P=0.238         | 
|ORDER RESTRICTED   |                  P=0.114                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                6/50 (12%)               7/52 (13%)               9/51 (18%)      | 
|POLY-3 RATE (b)    |                  1/38.18                  6/41.04                  7/39.86                  9/41.81         | 
|POLY-3 PERCENT (g) |                  2.6%                     14.6%                    17.6%                    21.5%           | 
|TERMINAL (d)       |                  1/22 (5%)                3/28 (11%)               1/24 (4%)                5/27 (19%)      | 
|FIRST INCIDENCE    |                  729 (T)                  491                      479                      491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.086                  P=0.090                  P=0.041 *                P=0.018 *       | 
|POLY 3             |                  P=0.075                  P=0.067                  P=0.033 *                P=0.011 *       | 
|POLY 1.5           |                  P=0.066                  P=0.060                  P=0.030 *                P=0.009 **      | 
|POLY 6             |                  P=0.086                  P=0.075                  P=0.038 *                P=0.014 *       | 
|LOGISTIC REGRESSION|                  P=0.057                  P=0.055                  P=0.031 *                P=0.010 *       | 
|COCH-ARM / FISHERS |                  P=0.055                  P=0.048 *                P=0.028 *                P=0.007 **      | 
|ORDER RESTRICTED   |                  P=0.010 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/50 (0%)                1/52 (2%)                6/51 (12%)      | 
|POLY-3 RATE (b)    |                  0/38.18                  0/39.59                  1/37.47                  6/41.36         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     2.7%                     14.5%           | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                3/27 (11%)      | 
|FIRST INCIDENCE    |                  ---                      ---                      710                      491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               (e)                      P=0.523                  P=0.026 *       | 
|POLY 3             |                  P<0.001 **               (e)                      P=0.496                  P=0.019 *       | 
|POLY 1.5           |                  P<0.001 **               (e)                      P=0.495                  P=0.017 *       | 
|POLY 6             |                  P<0.001 **               (e)                      P=0.499                  P=0.022 *       | 
|LOGISTIC REGRESSION|                  P<0.001 **               (e)                      P=0.499                  P=0.017 *       | 
|COCH-ARM / FISHERS |                  P<0.001 **               (e)                      P=0.495                  P=0.012 *       | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                1/50 (2%)                2/52 (4%)                1/51 (2%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  1/40.00                  2/37.86                  1/40.67         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.5%                     5.3%                     2.5%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      612                      618                      491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.676                  P=0.511                  P=0.240                  P=0.509         | 
|POLY 3             |                  P=0.684                  P=0.509                  P=0.234                  P=0.513         | 
|POLY 1.5           |                  P=0.675                  P=0.503                  P=0.233                  P=0.506         | 
|POLY 6             |                  P=0.694                  P=0.516                  P=0.239                  P=0.520         | 
|LOGISTIC REGRESSION|                  P=0.650                  P=0.470                  P=0.233                  P=0.429         | 
|COCH-ARM / FISHERS |                  P=0.661                  P=0.485                  P=0.243                  P=0.490         | 
|ORDER RESTRICTED   |                  P=0.223                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Artery                                                                                                     | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                0/50 (0%)                0/52 (0%)                2/51 (4%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  0/39.59                  0/37.39                  2/40.01         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     5.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                1/27 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      720             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.059                  (e)                      (e)                      P=0.290         | 
|POLY 3             |                  P=0.047 *                (e)                      (e)                      P=0.247         | 
|POLY 1.5           |                  P=0.046 *                (e)                      (e)                      P=0.241         | 
|POLY 6             |                  P=0.048 *                (e)                      (e)                      P=0.254         | 
|LOGISTIC REGRESSION|                  P=0.054                  (e)                      (e)                      P=0.268         | 
|COCH-ARM / FISHERS |                  P=0.045 *                (e)                      (e)                      P=0.238         | 
|ORDER RESTRICTED   |                  P=0.033 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/53 (0%)                3/50 (6%)                1/52 (2%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  0/38.18                  3/41.18                  1/37.39                  0/39.98         | 
|POLY-3 PERCENT (g) |                  0.0%                     7.3%                     2.7%                     0.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                1/24 (4%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  ---                      478                      729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.269N                 P=0.132                  P=0.517                  (e)             | 
|POLY 3             |                  P=0.244N                 P=0.132                  P=0.496                  (e)             | 
|POLY 1.5           |                  P=0.256N                 P=0.124                  P=0.495                  (e)             | 
|POLY 6             |                  P=0.234N                 P=0.142                  P=0.498                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.293N                 P=0.062                  P=0.517                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.282N                 P=0.111                  P=0.495                  (e)             | 
|ORDER RESTRICTED   |                  P=0.226N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/53 (8%)                1/50 (2%)                1/52 (2%)                0/51 (0%)       | 
|POLY-3 RATE (b)    |                  4/38.98                  1/39.59                  1/37.99                  0/39.98         | 
|POLY-3 PERCENT (g) |                  10.3%                    2.5%                     2.6%                     0.0%            | 
|TERMINAL (d)       |                  2/22 (9%)                1/28 (4%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  556                      729 (T)                  539                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.122N                 P=0.142N                 P=0.183N                 P=0.051N        | 
|POLY 3             |                  P=0.128N                 P=0.172N                 P=0.184N                 P=0.056N        | 
|POLY 1.5           |                  P=0.130N                 P=0.178N                 P=0.186N                 P=0.059N        | 
|POLY 6             |                  P=0.126N                 P=0.168N                 P=0.182N                 P=0.054N        | 
|LOGISTIC REGRESSION|                  P=0.132N                 P=0.172N                 P=0.186N                 P=0.061N        | 
|COCH-ARM / FISHERS |                  P=0.135N                 P=0.200N                 P=0.187N                 P=0.064N        | 
|ORDER RESTRICTED   |                  P=0.011N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  33/53 (62%)              48/48 (100%)             42/50 (84%)              45/47 (96%)     | 
|POLY-3 RATE (b)    |                  33/43.47                 48/48.00                 42/43.09                 45/45.28        | 
|POLY-3 PERCENT (g) |                  75.9%                    100.0%                   97.5%                    99.4%           | 
|TERMINAL (d)       |                  18/22 (82%)              28/28 (100%)             24/24 (100%)             26/26 (100%)    | 
|FIRST INCIDENCE    |                  449                      441                      479                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.371                  P=0.102                  P=0.141                  P=0.150         | 
|POLY 3             |                  P=0.016 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P=0.007 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P=0.048 *                P<0.001 **               P=0.002 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P=0.015 *                P<0.001 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P=0.009 **               P<0.001 **               P=0.011 *                P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/53 (2%)                0/48 (0%)                3/50 (6%)                0/47 (0%)       | 
|POLY-3 RATE (b)    |                  1/39.00                  0/38.21                  3/38.30                  0/37.46         | 
|POLY-3 PERCENT (g) |                  2.6%                     0.0%                     7.8%                     0.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  418                      ---                      96                       ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.324N                 P=0.500N                 P=0.296                  P=0.504N        | 
|POLY 3             |                  P=0.328N                 P=0.504N                 P=0.298                  P=0.508N        | 
|POLY 1.5           |                  P=0.333N                 P=0.509N                 P=0.292                  P=0.513N        | 
|POLY 6             |                  P=0.324N                 P=0.499N                 P=0.307                  P=0.503N        | 
|LOGISTIC REGRESSION|                  P=0.501N                 P=0.699N                 P=0.429                  P=0.630N        | 
|COCH-ARM / FISHERS |                  P=0.340N                 P=0.525N                 P=0.287                  P=0.530N        | 
|ORDER RESTRICTED   |                  P=0.270N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                0/48 (0%)                0/50 (0%)                0/47 (0%)       | 
|POLY-3 RATE (b)    |                  2/39.43                  0/38.21                  0/35.50                  0/37.46         | 
|POLY-3 PERCENT (g) |                  5.1%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/22 (0%)                0/28 (0%)                0/24 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  85                       ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.419N                 P=0.250N                 P=0.251N                 P=0.244N        | 
|POLY 3             |                  P=0.427N                 P=0.243N                 P=0.260N                 P=0.248N        | 
|POLY 1.5           |                  P=0.428N                 P=0.249N                 P=0.261N                 P=0.254N        | 
|POLY 6             |                  P=0.429N                 P=0.238N                 P=0.258N                 P=0.242N        | 
|LOGISTIC REGRESSION|                  P=0.539N                 P=0.501N                 P=0.180N                 P=0.390N        | 
|COCH-ARM / FISHERS |                  P=0.437N                 P=0.273N                 P=0.262N                 P=0.278N        | 
|ORDER RESTRICTED   |                  P=0.033N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  15/53 (28%)              16/49 (33%)              12/52 (23%)              17/50 (34%)     | 
|POLY-3 RATE (b)    |                  15/41.78                 16/42.03                 12/38.36                 17/42.66        | 
|POLY-3 PERCENT (g) |                  35.9%                    38.1%                    31.3%                    39.9%           | 
|TERMINAL (d)       |                  7/22 (32%)               10/28 (36%)              7/24 (29%)               12/27 (44%)     | 
|FIRST INCIDENCE    |                  377                      491                      552                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.432                  P=0.482N                 P=0.307N                 P=0.563N        | 
|POLY 3             |                  P=0.372                  P=0.509                  P=0.419N                 P=0.440         | 
|POLY 1.5           |                  P=0.344                  P=0.476                  P=0.405N                 P=0.407         | 
|POLY 6             |                  P=0.392                  P=0.537                  P=0.422N                 P=0.467         | 
|LOGISTIC REGRESSION|                  P=0.330                  P=0.440                  P=0.367N                 P=0.381         | 
|COCH-ARM / FISHERS |                  P=0.280                  P=0.396                  P=0.349N                 P=0.340         | 
|ORDER RESTRICTED   |                  P=0.509                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/53 (4%)                0/49 (0%)                0/52 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/38.43                  0/39.12                  0/36.79                  0/39.67         | 
|POLY-3 PERCENT (g) |                  5.2%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/22 (5%)                0/28 (0%)                0/24 (0%)                0/27 (0%)       | 
|FIRST INCIDENCE    |                  664                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.407N                 P=0.217N                 P=0.241N                 P=0.217N        | 
|POLY 3             |                  P=0.422N                 P=0.233N                 P=0.246N                 P=0.230N        | 
|POLY 1.5           |                  P=0.422N                 P=0.239N                 P=0.247N                 P=0.236N        | 
|POLY 6             |                  P=0.423N                 P=0.227N                 P=0.244N                 P=0.223N        | 
|LOGISTIC REGRESSION|                  P=0.411N                 P=0.229N                 P=0.243N                 P=0.226N        | 
|COCH-ARM / FISHERS |                  P=0.427N                 P=0.268N                 P=0.252N                 P=0.262N        | 
|ORDER RESTRICTED   |                  P=0.027N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  14/53 (26%)              28/49 (57%)              35/52 (67%)              44/50 (88%)     | 
|POLY-3 RATE (b)    |                  14/43.47                 28/43.27                 35/45.78                 44/47.40        | 
|POLY-3 PERCENT (g) |                  32.2%                    64.7%                    76.5%                    92.8%           | 
|TERMINAL (d)       |                  5/22 (23%)               20/28 (71%)              20/24 (83%)              27/27 (100%)    | 
|FIRST INCIDENCE    |                  418                      441                      142                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.036 *                P<0.001 **               P<0.001 **      | 
|POLY 3             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 1.5           |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|POLY 6             |                  P<0.001 **               P<0.001 **               P<0.001 **               P<0.001 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.002 **               P<0.001 **               P<0.001 **      | 
|COCH-ARM / FISHERS |                  P<0.001 **               P=0.002 **               P<0.001 **               P<0.001 **      | 
|ORDER RESTRICTED   |                  P<0.001 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  23/23 (100%)             25/25 (100%)             35/35 (100%)             42/42 (100%)    | 
|POLY-3 RATE (b)    |                  23/23.00                 25/25.00                 35/35.00                 42/42.00        | 
|POLY-3 PERCENT (g) |                  100.0%                   100.0%                   100.0%                   100.0%          | 
|TERMINAL (d)       |                  10/10 (100%)             17/17 (100%)             17/17 (100%)             25/25 (100%)    | 
|FIRST INCIDENCE    |                  451                      491                      254                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  (e)                      (e)                      (e)                      (e)             | 
|POLY 3             |                  (e)                      (e)                      (e)                      (e)             | 
|POLY 1.5           |                  (e)                      (e)                      (e)                      (e)             | 
|POLY 6             |                  (e)                      (e)                      (e)                      (e)             | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  (e)                      (e)                      (e)                      (e)             | 
|ORDER RESTRICTED   |                  (e)                      (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/53 (13%)               3/49 (6%)                7/52 (13%)               8/50 (16%)      | 
|POLY-3 RATE (b)    |                  7/40.77                  3/39.40                  7/39.03                  8/39.25         | 
|POLY-3 PERCENT (g) |                  17.2%                    7.6%                     17.9%                    20.4%           | 
|TERMINAL (d)       |                  3/22 (14%)               2/28 (7%)                4/24 (17%)               7/27 (26%)      | 
|FIRST INCIDENCE    |                  345                      569                      499                      668             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.322                  P=0.120N                 P=0.589N                 P=0.598N        | 
|POLY 3             |                  P=0.233                  P=0.168N                 P=0.581                  P=0.467         | 
|POLY 1.5           |                  P=0.236                  P=0.174N                 P=0.582                  P=0.465         | 
|POLY 6             |                  P=0.229                  P=0.161N                 P=0.589                  P=0.471         | 
|LOGISTIC REGRESSION|                  P=0.251                  P=0.222N                 P=0.599                  P=0.479         | 
|COCH-ARM / FISHERS |                  P=0.237                  P=0.193N                 P=0.598                  P=0.451         | 
|ORDER RESTRICTED   |                  P=0.258                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                2/50 (4%)                10/52 (19%)              8/50 (16%)      | 
|POLY-3 RATE (b)    |                  3/39.57                  2/39.59                  10/39.56                 8/39.90         | 
|POLY-3 PERCENT (g) |                  7.6%                     5.1%                     25.3%                    20.1%           | 
|TERMINAL (d)       |                  0/22 (0%)                2/28 (7%)                6/24 (25%)               5/27 (19%)      | 
|FIRST INCIDENCE    |                  345                      729 (T)                  506                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.181                  P=0.466N                 P=0.046 *                P=0.150         | 
|POLY 3             |                  P=0.123                  P=0.500N                 P=0.031 *                P=0.097         | 
|POLY 1.5           |                  P=0.117                  P=0.506N                 P=0.031 *                P=0.092         | 
|POLY 6             |                  P=0.132                  P=0.496N                 P=0.033 *                P=0.103         | 
|LOGISTIC REGRESSION|                  P=0.126                  P=0.550N                 P=0.035 *                P=0.091         | 
|COCH-ARM / FISHERS |                  P=0.115                  P=0.528N                 P=0.033 *                P=0.083         | 
|ORDER RESTRICTED   |                  P=0.023 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/53 (6%)                4/50 (8%)                7/52 (13%)               8/50 (16%)      | 
|POLY-3 RATE (b)    |                  3/38.79                  4/40.12                  7/39.10                  8/39.83         | 
|POLY-3 PERCENT (g) |                  7.7%                     10.0%                    17.9%                    20.1%           | 
|TERMINAL (d)       |                  2/22 (9%)                3/28 (11%)               2/24 (8%)                6/27 (22%)      | 
|FIRST INCIDENCE    |                  533                      567                      310                      588             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.166                  P=0.602                  P=0.181                  P=0.159         | 
|POLY 3             |                  P=0.120                  P=0.518                  P=0.156                  P=0.102         | 
|POLY 1.5           |                  P=0.114                  P=0.504                  P=0.153                  P=0.095         | 
|POLY 6             |                  P=0.127                  P=0.533                  P=0.165                  P=0.112         | 
|LOGISTIC REGRESSION|                  P=0.119                  P=0.507                  P=0.151                  P=0.105         | 
|COCH-ARM / FISHERS |                  P=0.106                  P=0.467                  P=0.152                  P=0.083         | 
|ORDER RESTRICTED   |                  P=0.084                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  27/53 (51%)              27/50 (54%)              36/52 (69%)              34/50 (68%)     | 
|POLY-3 RATE (b)    |                  27/44.63                 27/43.83                 36/44.30                 34/45.44        | 
|POLY-3 PERCENT (g) |                  60.5%                    61.6%                    81.3%                    74.8%           | 
|TERMINAL (d)       |                  12/22 (55%)              18/28 (64%)              21/24 (88%)              20/27 (74%)     | 
|FIRST INCIDENCE    |                  345                      441                      310                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.351                  P=0.323N                 P=0.133                  P=0.368         | 
|POLY 3             |                  P=0.163                  P=0.546                  P=0.018 *                P=0.097         | 
|POLY 1.5           |                  P=0.133                  P=0.531                  P=0.024 *                P=0.081         | 
|POLY 6             |                  P=0.203                  P=0.546                  P=0.012 *                P=0.114         | 
|LOGISTIC REGRESSION|                  P=0.130                  P=0.556                  P=0.036 *                P=0.081         | 
|COCH-ARM / FISHERS |                  P=0.103                  P=0.455                  P=0.043 *                P=0.059         | 
|ORDER RESTRICTED   |                  P=0.035 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 NG /                   300 NG /                 300 NG /                 300 NG /        | 
|                   |                  0 UG                     100 UG                   300 UG                   3000 UG         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  28/53 (53%)              25/50 (50%)              18/52 (35%)              15/50 (30%)     | 
|POLY-3 RATE (b)    |                  28/44.64                 25/44.81                 18/41.18                 15/41.92        | 
|POLY-3 PERCENT (g) |                  62.7%                    55.8%                    43.7%                    35.8%           | 
|TERMINAL (d)       |                  13/22 (59%)              16/28 (57%)              13/24 (54%)              8/27 (30%)      | 
|FIRST INCIDENCE    |                  345                      441                      142                      409             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.013N*                P=0.167N                 P=0.040N*                P=0.006N**      | 
|POLY 3             |                  P=0.014N*                P=0.319N                 P=0.051N                 P=0.007N**      | 
|POLY 1.5           |                  P=0.017N*                P=0.356N                 P=0.044N*                P=0.009N**      | 
|POLY 6             |                  P=0.011N*                P=0.299N                 P=0.066N                 P=0.007N**      | 
|LOGISTIC REGRESSION|                  P=0.021N*                P=0.421N                 P=0.046N*                P=0.012N*       | 
|COCH-ARM / FISHERS |                  P=0.024N*                P=0.464N                 P=0.046N*                P=0.016N*       | 
|ORDER RESTRICTED   |                  P=0.005N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.