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TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30

                                                            FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    10 NG / 10 UG
                               Include 003    100 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 007    1000 NG/1000 UG




























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           98           98                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           19           24           19           20                        
    Natural Death                                      8           12            6           10            7                        
    Dosing Accident                                    1            1            1                         2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           21           22           24           24                        
                                                                                                                                    
  Animals Examined Microscopically                    53           53           53           53           53                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (53)         (52)         (53)         (52)                      
      Cyst                                                                                                 1 [3.0]                  
      Perforation                                                                1                         2                        
      Muscularis, Inflammation                         3 [1.3]      1 [3.0]      1 [2.0]      3 [1.3]      3 [2.0]                  
      Periesophageal Tissue, Hemorrhage                                                                    1 [3.0]                  
      Periesophageal Tissue, Inflammation                                        1 [4.0]                   1 [3.0]                  
   Intestine Large, Colon                             (53)         (53)         (53)         (52)         (49)                      
      Hyperplasia, Lymphoid                                                      1 [2.0]                                            
      Parasite Metazoan                                             2                                                               
   Intestine Large, Rectum                            (53)         (53)         (53)         (53)         (50)                      
      Metaplasia, Squamous                                                                                 1 [3.0]                  
      Parasite Metazoan                                2                                      1            3                        
   Intestine Large, Cecum                             (53)         (53)         (53)         (52)         (49)                      
      Mineralization                                                             1 [3.0]                                            
   Intestine Small, Jejunum                           (53)         (53)         (52)         (52)         (49)                      
      Hyperplasia, Lymphoid                                                      1 [2.0]      2 [3.5]      1 [3.0]                  
      Ulcer                                                                                   1 [4.0]                               
   Intestine Small, Ileum                             (53)         (53)         (52)         (52)         (49)                      
      Hyperplasia, Lymphoid                            1 [2.0]                                                                      
   Liver                                              (53)         (53)         (52)         (52)         (51)                      
      Angiectasis                                      3 [1.7]      1 [1.0]      1 [1.0]      2 [2.0]      5 [2.2]                  
      Basophilic Focus                                 9            7            8            2            3                        
      Basophilic Focus, Multiple                      13           15            6            1            3                        
      Cholangiofibrosis                                             1 [1.0]                   7 [2.0]     39 [3.2]                  
      Clear Cell Focus                                 3            2            2            3            1                        
      Clear Cell Focus, Multiple                       6            1            1                                                  
      Eosinophilic Focus                               7            8            4            7            1                        
      Eosinophilic Focus, Multiple                     7            8           26           33           17                        
      Fatty Change, Diffuse                            3 [1.7]      1 [1.0]      9 [1.7]     31 [1.5]     38 [1.6]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change, Focal                              3 [1.0]      4 [1.0]      7 [1.1]      1 [2.0]     12 [1.9]                  
      Hematopoietic Cell Proliferation                27 [1.2]     29 [1.0]     30 [1.1]     19 [1.1]     11 [1.0]                  
      Hepatodiaphragmatic Nodule                                    2                                                               
      Hyperplasia, Nodular                                                       2           24           42                        
      Inflammation                                    44 [1.1]     41 [1.0]     46 [1.1]     48 [1.2]     46 [1.5]                  
      Metaplasia                                                                                           1 [1.0]                  
      Mixed Cell Focus                                 7            3            4            2            1                        
      Mixed Cell Focus, Multiple                      19           19           26           24            2                        
      Necrosis                                         4 [1.8]      8 [2.0]      5 [2.0]      4 [1.0]     20 [2.3]                  
      Pigmentation                                     2 [1.0]      5 [1.2]     38 [1.3]     50 [1.9]     50 [2.0]                  
      Toxic Hepatopathy                                             2 [1.0]     34 [1.2]     48 [2.0]     49 [3.5]                  
      Bile Duct, Cyst                                  4 [2.3]      3 [2.3]      1 [2.0]      5 [2.4]     23 [2.4]                  
      Bile Duct, Dilatation                                         1 [4.0]                                                         
      Bile Duct, Fibrosis                              1 [1.0]      3 [1.0]      3 [1.0]      4 [1.0]                               
      Bile Duct, Hyperplasia                           8 [1.3]      2 [1.5]      9 [1.6]     29 [1.4]     46 [2.0]                  
      Centrilobular, Degeneration                      5 [1.8]      7 [2.0]      2 [2.5]      4 [1.5]      3 [2.3]                  
      Centrilobular, Fibrosis                                                                 1 [1.0]      1 [2.0]                  
      Hepatocyte, Hypertrophy                          1 [1.0]      7 [1.0]     17 [1.4]     33 [2.1]     50 [3.3]                  
      Hepatocyte, Multinucleated                                                14 [1.4]     46 [1.6]     48 [1.9]                  
      Oval Cell, Hyperplasia                           2 [1.0]      2 [1.0]     15 [1.3]     39 [1.6]     46 [2.9]                  
      Portal, Fibrosis                                                                        7 [1.4]     34 [2.3]                  
      Serosa, Inflammation, Chronic Active             1 [3.0]                                                                      
   Mesentery                                          (47)         (47)         (46)         (47)         (42)                      
      Artery, Inflammation, Chronic Active             1 [1.0]      1 [1.0]      1 [2.0]      2 [2.5]      4 [2.5]                  
      Fat, Necrosis                                                 2 [3.0]      2 [2.5]      1 [3.0]                               
   Oral Mucosa                                        (12)         (11)         (25)         (30)         (36)                      
      Gingival, Hyperplasia, Squamous                  8 [1.3]      8 [1.0]     18 [1.6]     22 [1.6]     24 [1.8]                  
      Pharyngeal, Inflammation                                                                             1 [3.0]                  
   Pancreas                                           (53)         (53)         (52)         (52)         (50)                      
      Inflammation, Chronic Active                                  3 [1.3]      3 [1.3]      1 [1.0]      4 [1.8]                  
      Acinus, Atrophy                                               2 [1.5]      1 [2.0]      1 [1.0]      8 [1.6]                  
      Acinus, Hyperplasia                              2 [1.5]                                1 [3.0]                               
      Acinus, Vacuolization Cytoplasmic                                                       7 [1.0]     40 [1.9]                  
      Artery, Inflammation, Chronic Active                                       1 [3.0]      2 [2.5]      2 [3.0]                  
      Duct, Dilatation                                                                                     1 [3.0]                  
   Salivary Glands                                    (53)         (51)         (52)         (50)         (52)                      
      Inflammation, Chronic Active                                               1 [3.0]                                            
   Stomach, Forestomach                               (53)         (53)         (52)         (52)         (51)                      
      Hyperkeratosis                                                             1 [3.0]      2 [2.0]                               
      Hyperplasia, Squamous                            1 [2.0]      1 [1.0]      2 [1.5]      7 [2.0]      8 [1.8]                  
      Inflammation                                                               1 [4.0]      1 [2.0]                               
      Mineralization                                   1 [1.0]      1 [2.0]                                                         
      Ulcer                                                                      1 [2.0]      2 [2.5]      1 [2.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (53)         (53)         (52)         (52)         (51)                      
      Cyst                                                                                                 1 [1.0]                  
      Ectopic Tissue                                                                          1 [4.0]                               
      Erosion                                                                                 1 [2.0]      2 [2.0]                  
      Inflammation, Chronic Active                                               1 [4.0]                                            
      Mineralization                                   4 [1.5]      3 [1.3]      3 [1.0]      1 [2.0]                               
      Ulcer                                                                      1 [3.0]                                            
   Tooth                                              (23)         (14)         (33)         (35)         (31)                      
      Peridontal Tissue, Inflammation                 23 [1.2]     14 [1.6]     33 [1.2]     35 [1.5]     31 [1.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (53)         (52)         (53)         (52)                      
      Aorta, Mineralization                                                                   1 [3.0]                               
   Heart                                              (53)         (52)         (52)         (53)         (52)                      
      Cardiomyopathy                                  22 [1.0]     19 [1.1]     22 [1.0]     26 [1.1]     15 [1.0]                  
      Fibrosis                                                                                             1 [2.0]                  
      Hemorrhage                                                                                           1 [3.0]                  
      Inflammation, Chronic Active                     1 [4.0]                                             1 [3.0]                  
      Thrombosis                                                                                           1 [3.0]                  
      Coronary Artery, Inflammation, Chronic Active                              1 [1.0]                   6 [1.2]                  
      Pericardium, Necrosis                                                                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (53)         (52)         (52)         (51)                      
      Angiectasis                                     17 [1.4]     26 [1.7]     33 [1.6]     23 [1.7]      5 [1.8]                  
      Atrophy                                                                                 3 [3.0]     35 [2.6]                  
      Degeneration, Cystic                            13 [2.1]     12 [2.3]     13 [2.2]     14 [1.8]     16 [1.9]                  
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Hyperplasia                                     11 [2.2]     18 [2.2]     23 [2.2]     25 [2.6]     18 [2.6]                  
      Hypertrophy                                     47 [2.0]     38 [1.9]     44 [2.0]     41 [2.3]     32 [2.2]                  
      Necrosis                                         1 [3.0]                                             1 [2.0]                  
      Vacuolization Cytoplasmic                       11 [1.5]     12 [1.6]     14 [1.2]     10 [1.4]     13 [1.6]                  
   Adrenal Medulla                                    (52)         (53)         (52)         (52)         (51)                      
      Hyperplasia                                     15 [1.8]     13 [1.8]     14 [2.0]     13 [2.1]      3 [2.0]                  
   Islets, Pancreatic                                 (53)         (53)         (52)         (52)         (50)                      
      Hyperplasia                                                                1 [2.0]                                            
   Parathyroid Gland                                  (45)         (47)         (46)         (47)         (46)                      
      Hyperplasia                                                   1 [2.0]                                                         
   Pituitary Gland                                    (53)         (53)         (53)         (52)         (52)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Angiectasis                                     17 [2.4]     20 [2.2]     15 [2.5]     17 [2.0]      1 [2.0]                  
      Cyst                                             1 [2.0]      3 [2.7]                                                         
      Cytoplasmic Alteration                                                     3 [2.0]                                            
      Inflammation                                                                            1 [2.0]                               
      Vacuolization Cytoplasmic                                                               1 [2.0]                               
      Pars Distalis, Hyperplasia                      13 [2.4]     13 [2.5]     19 [2.5]     20 [2.5]     13 [2.0]                  
      Pars Intermedia, Hyperplasia                                                                         2 [2.5]                  
   Thyroid Gland                                      (53)         (53)         (51)         (52)         (52)                      
      C-Cell, Hyperplasia                             15 [2.1]     19 [1.9]     22 [2.1]     12 [2.3]     15 [1.7]                  
      Follicle, Cyst                                   2 [2.0]                                                                      
      Follicular Cell, Hypertrophy                    14 [1.3]     17 [1.3]     34 [1.4]     35 [1.5]     42 [1.9]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (53)         (53)         (53)         (50)                      
      Inflammation                                    45 [1.8]     49 [1.8]     46 [1.7]     40 [1.4]     23 [1.1]                  
      Duct, Cyst                                      38 [2.1]     40 [2.0]     48 [2.4]     43 [2.3]     43 [2.4]                  
   Ovary                                              (53)         (53)         (52)         (52)         (49)                      
      Atrophy                                         45 [4.0]     44 [4.0]     45 [4.0]     43 [4.0]     16 [3.8]                  
      Cyst                                            14 [2.4]      7 [2.1]     17 [2.2]     14 [2.6]     13 [2.5]                  
      Inflammation, Chronic Active                     1 [2.0]      1 [4.0]                                1 [4.0]                  
      Inflammation, Suppurative                                                               1 [2.0]                               
   Oviduct                                            (1)                       (1)          (2)          (3)                       
      Cyst                                             1 [2.0]                   1 [3.0]      2 [2.0]                               
      Inflammation, Chronic Active                                               1 [2.0]                   3 [3.0]                  
   Uterus                                             (53)         (53)         (53)         (52)         (50)                      
      Adenomyosis                                                                1 [2.0]                   1 [3.0]                  
      Hemorrhage                                                                                           1 [3.0]                  
      Hyperplasia                                                   1 [3.0]                                                         
      Inflammation, Chronic Active                     3 [2.3]                   1 [3.0]      7 [2.6]      2 [3.5]                  
      Inflammation, Suppurative                        3 [1.3]      5 [1.8]      8 [1.8]     10 [1.6]      5 [2.0]                  
      Metaplasia, Squamous                            27 [2.0]     30 [2.2]     35 [2.1]     36 [2.9]     14 [2.4]                  
      Ulcer                                                                                                1 [3.0]                  
      Endometrium, Hyperplasia, Cystic                28 [2.0]     23 [2.1]     34 [2.3]     18 [2.2]     12 [2.6]                  
   Vagina                                             (1)          (1)          (1)          (1)                                    
      Inflammation                                                               1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (53)         (53)         (53)         (53)                      
      Atrophy                                                       1 [3.0]                                                         
      Degeneration                                                               1 [3.0]                                            
      Hyperplasia                                     39 [3.2]     38 [3.0]     42 [2.9]     48 [2.8]     49 [2.7]                  
   Lymph Node                                         (4)          (7)          (2)          (7)          (14)                      
      Angiectasis                                                                             1 [2.0]      1 [2.0]                  
      Inguinal, Hyperplasia, Plasma Cell                                                      1 [2.0]                               
      Lumbar, Ectasia                                  4 [2.3]      4 [2.3]                   1 [2.0]                               
      Lumbar, Hemorrhage                                            2 [2.0]                                                         
      Lumbar, Hyperplasia                                           1 [3.0]                                                         
      Lumbar, Hyperplasia, Plasma Cell                 4 [2.3]      1 [2.0]                                                         
      Mediastinal, Ectasia                                                                                 3 [2.0]                  
      Mediastinal, Hemorrhage                                                                 1 [2.0]      2 [2.5]                  
      Mediastinal, Hyperplasia, Histiocytic                         1 [2.0]                   1 [2.0]      3 [2.3]                  
      Mediastinal, Hyperplasia, Lymphoid                            1 [2.0]                                                         
      Mediastinal, Hyperplasia, Plasma Cell                                                                2 [2.0]                  
      Pancreatic, Hyperplasia, Histiocytic                                                    1 [2.0]      3 [2.7]                  
      Pancreatic, Hyperplasia, Plasma Cell                                                                 1 [3.0]                  
      Pancreatic, Pigmentation                                                                1 [2.0]      1 [2.0]                  
      Renal, Ectasia                                                1 [2.0]      1 [2.0]      1 [2.0]      1 [2.0]                  
      Renal, Hemorrhage                                                          1 [2.0]                                            
      Renal, Hyperplasia, Histiocytic                                                         1 [2.0]      2 [2.5]                  
      Renal, Hyperplasia, Lymphoid                                                                         1 [3.0]                  
      Renal, Hyperplasia, Plasma Cell                               1 [3.0]                   1 [2.0]                               
   Lymph Node, Mandibular                             (53)         (51)         (52)         (50)         (51)                      
      Congestion                                                                              1 [3.0]                               
      Ectasia                                                       3 [2.0]      6 [1.7]      3 [1.7]      6 [2.3]                  
      Hemorrhage                                                    1 [2.0]                                1 [2.0]                  
      Hyperplasia, Lymphoid                            1 [2.0]      2 [2.0]      3 [2.0]      2 [2.0]      5 [2.4]                  
      Hyperplasia, Plasma Cell                        37 [2.2]     37 [2.2]     40 [2.4]     36 [2.4]     31 [2.5]                  
   Lymph Node, Mesenteric                             (53)         (53)         (52)         (52)         (49)                      
      Hemorrhage                                                                              1 [2.0]                               
      Hyperplasia, Histiocytic                                                                1 [2.0]      2 [2.5]                  
      Hyperplasia, Lymphoid                                                      1 [4.0]                   1 [3.0]                  
      Inflammation, Chronic Active                                               1 [4.0]                                            
   Spleen                                             (53)         (53)         (52)         (52)         (50)                      
      Fibrosis                                                                                1 [3.0]                               
      Hematopoietic Cell Proliferation                51 [2.2]     51 [2.1]     49 [2.2]     47 [2.0]     44 [1.8]                  
      Hyperplasia                                                                1 [2.0]                                            
      Pigmentation                                    47 [1.5]     46 [1.5]     43 [1.5]     51 [1.7]     46 [1.7]                  
      Lymphoid Follicle, Atrophy                                                 2 [2.0]      4 [2.5]      5 [2.4]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Red Pulp, Atrophy                                1 [2.0]                   1 [2.0]                   5 [2.2]                  
   Thymus                                             (53)         (50)         (48)         (50)         (51)                      
      Atrophy                                         33 [2.3]     33 [2.5]     43 [2.8]     42 [3.8]     49 [3.6]                  
      Cyst                                                                                    1 [3.0]                               
      Hemorrhage                                       1 [2.0]                                3 [2.3]      1 [3.0]                  
      Hyperplasia, Lymphoid                            2 [2.5]                                                                      
      Inflammation                                                                                         1 [3.0]                  
      Epithelial Cell, Hyperplasia                                                            1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (53)         (52)         (53)         (52)                      
      Cyst                                             3 [3.0]      2 [2.0]      2 [2.0]      3 [2.3]      1 [3.0]                  
      Hyperplasia                                     29 [1.5]     29 [1.4]     25 [1.5]     22 [1.4]      3 [1.0]                  
      Inflammation, Granulomatous                      5 [2.0]                   4 [2.3]      3 [1.7]                               
      Duct, Cyst                                       1 [4.0]                                                                      
   Skin                                               (53)         (53)         (53)         (53)         (53)                      
      Angiectasis                                      1 [3.0]                                                                      
      Cyst Epithelial Inclusion                                                               1                                     
      Fibrosis                                         1 [3.0]                                                                      
      Inflammation                                                               1 [2.0]                   1 [3.0]                  
      Ulcer                                                                      2 [2.0]                   1 [3.0]                  
      Dermis, Fibrosis                                                           1 [3.0]                                            
      Epidermis, Hyperplasia                                                     1 [4.0]                                            
      Subcutaneous Tissue, Inflammation                                          1 [4.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                       (1)          (1)                       
      Hemorrhage                                                                                           1 [3.0]                  
      Inflammation                                                                                         1 [3.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)         (52)         (52)                      
      Hemorrhage                                                                 1 [3.0]      1 [3.0]                               
      Hydrocephalus                                    1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (52)         (53)         (52)                      
      Hemorrhage                                                                 1 [2.0]                                            
      Infiltration Cellular, Histiocyte               47 [1.8]     41 [1.9]     47 [1.6]     46 [1.7]     45 [1.5]                  
      Inflammation                                     8 [1.8]      5 [2.2]      2 [2.0]      4 [1.8]      1 [3.0]                  
      Metaplasia, Squamous                                                       1 [1.0]      2 [1.5]     11 [2.1]                  
      Mineralization                                                1 [1.0]                   1 [2.0]                               
      Alveolar Epithelium, Hyperplasia                23 [1.2]     20 [1.4]     17 [1.1]      5 [1.4]      5 [1.4]                  
      Alveolar Epithelium, Metaplasia, Bronchiolar                  6 [1.5]     23 [1.4]     34 [1.7]     32 [1.9]                  
      Bronchiole, Hyperplasia                                                                              1 [3.0]                  
      Mediastinum, Hemorrhage                                                                              1 [3.0]                  
      Mediastinum, Necrosis                                                                   1 [3.0]                               
      Serosa, Inflammation                                                                    1 [2.0]                               
   Nose                                               (53)         (53)         (53)         (53)         (53)                      
      Hyperplasia                                                                                          1 [3.0]                  
      Inflammation                                    22 [1.5]     13 [1.2]     13 [1.2]     13 [1.6]     31 [1.3]                  
      Glands, Hyperplasia                                                                                  8 [2.0]                  
      Olfactory Epithelium, Degeneration               1 [2.0]                                             2 [2.0]                  
      Olfactory Epithelium, Metaplasia                 4 [2.3]      3 [2.0]      5 [2.0]      6 [2.2]     15 [2.2]                  
      Respiratory Epithelium, Hyperplasia             10 [2.4]      5 [1.8]      7 [2.0]     11 [2.1]     20 [2.6]                  
      Respiratory Epithelium, Metaplasia               1 [2.0]                                                                      
      Respiratory Epithelium, Vacuolization                                                                                         
        Cytoplasmic                                                 1 [2.0]                                                         
   Trachea                                            (53)         (53)         (52)         (53)         (52)                      
      Inflammation                                     1 [1.0]                                                                      
      Peritracheal Tissue, Hemorrhage                                                                      1 [3.0]                  
      Peritracheal Tissue, Inflammation                                                                    1 [3.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (53)         (53)         (53)         (52)         (52)                      
      Anterior Chamber, Ciliary Body, Cornea,                                                                                       
        Inflammation                                                                          1 [3.0]      3 [3.0]                  
      Cornea, Inflammation                                                                    1 [3.0]                               
      Retina, Atrophy                                  1 [2.0]      3 [2.0]      4 [2.3]      2 [2.0]      5 [2.2]                  
   Harderian Gland                                    (53)         (53)         (53)         (52)         (52)                      
      Inflammation                                    20 [1.0]     14 [1.1]     16 [1.1]     14 [1.3]     16 [1.4]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (53)         (52)         (52)         (51)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:11:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Accumulation, Hyaline Droplet                    2 [2.0]                   1 [1.0]      1 [2.0]      1 [1.0]                  
      Calculus Gross Observation                                    1                                                               
      Calculus Micro Observation Only                  7            4            1            4            1                        
      Casts Protein                                    2 [2.0]      1 [1.0]                                                         
      Cyst                                                          1 [3.0]      1 [2.0]      1 [3.0]                               
      Infarct                                                                    1 [3.0]                   1 [2.0]                  
      Inflammation, Chronic Active                     1 [2.0]      1 [2.0]                   1 [3.0]      1 [3.0]                  
      Inflammation, Suppurative                        5 [1.2]      3 [1.3]      1 [1.0]      5 [1.0]      1 [2.0]                  
      Mineralization                                  42 [1.0]     38 [1.1]     39 [1.0]     42 [1.0]     35 [1.0]                  
      Necrosis                                                                   1 [1.0]                                            
      Nephropathy                                     29 [1.2]     22 [1.0]     29 [1.1]     34 [1.3]     43 [2.2]                  
      Pigmentation                                                  1 [2.0]      3 [1.0]      7 [1.3]     35 [2.0]                  
      Pelvis, Dilatation                               1 [2.0]                                2 [2.5]      1 [3.0]                  
      Pelvis, Inflammation                             3 [2.0]                   4 [1.8]      3 [2.3]      5 [1.8]                  
      Renal Tubule, Degeneration                                                 1 [3.0]      2 [2.0]      1 [3.0]                  
      Transitional Epithelium, Hyperplasia             2 [2.0]      2 [1.0]      4 [1.8]     11 [1.9]      6 [2.2]                  
   Ureter                                             (1)          (1)                       (1)          (1)                       
      Inflammation                                     1 [2.0]                                1 [2.0]                               
      Mineralization                                                                                       1 [3.0]                  
      Transitional Epithelium, Hyperplasia             1 [3.0]                                             1 [3.0]                  
   Urinary Bladder                                    (53)         (53)         (53)         (52)         (50)                      
      Inflammation                                     7 [1.1]      8 [1.1]      5 [1.2]      7 [1.4]                               
      Transitional Epithelium, Hyperplasia                                                    1 [2.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
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