Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/17057

TDMS Study 96021-01 Pathology Tables


NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03
Route: GAVAGE                                                                                                     Time: 09:34:31

                                                            FINAL #3




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  35065-27-1

       Lock Date:  01/16/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           98           98           80           
  Early Deaths                                                                                                                      
    Natural Death                                     11           15            8            9           15           11           
    Moribund Sacrifice                                18           23           17           22           18           19           
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           16           28           20           20           21           
    Natural Death                                                                             1                                     
                                                                                                                                    
  Animals Examined Microscopically                    53           54           53           53           53           51           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (54)         (53)         (53)         (53)         (51)         
      Muscularis, Inflammation                                      3 (6%)                    1 (2%)       2 (4%)       1 (2%)      
      Periesophageal Tissue, Hemorrhage                                                       1 (2%)                                
      Periesophageal Tissue, Inflammation                                                     1 (2%)                                
   Intestine Large, Colon                             (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Parasite Metazoan                                             1 (2%)       1 (2%)                    1 (2%)       2 (4%)      
   Intestine Large, Rectum                            (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Parasite Metazoan                                1 (2%)       2 (4%)       3 (6%)       7 (13%)      5 (9%)       5 (10%)     
   Intestine Large, Cecum                             (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 (2%)      
   Intestine Small, Duodenum                          (53)         (54)         (53)         (53)         (53)         (51)         
      Parasite Metazoan                                                                                                 1 (2%)      
   Intestine Small, Jejunum                           (53)         (54)         (53)         (53)         (53)         (50)         
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                           1 (2%)      
   Intestine Small, Ileum                             (52)         (54)         (53)         (53)         (53)         (50)         
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                      5 (9%)       2 (4%)       2 (4%)       1 (2%)       8 (15%)      4 (8%)      
      Basophilic Focus                                 8 (15%)      5 (9%)      16 (30%)      6 (11%)      3 (6%)       8 (16%)     
      Basophilic Focus, Multiple                       8 (15%)     12 (22%)      9 (17%)      7 (13%)      7 (13%)      2 (4%)      
      Cholangiofibrosis                                                                                    1 (2%)                   
      Clear Cell Focus                                 3 (6%)       3 (6%)       4 (8%)                                 2 (4%)      
      Clear Cell Focus, Multiple                       3 (6%)       2 (4%)       1 (2%)                                             
      Eosinophilic Focus                               5 (9%)       1 (2%)       8 (15%)      7 (13%)     14 (26%)      6 (12%)     
      Eosinophilic Focus, Multiple                     7 (13%)      1 (2%)       8 (15%)     12 (23%)      9 (17%)     12 (24%)     
      Fatty Change, Diffuse                            3 (6%)       7 (13%)      2 (4%)      11 (21%)     21 (40%)     17 (33%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change, Focal                              4 (8%)                    3 (6%)       5 (9%)       4 (8%)       1 (2%)      
      Hematopoietic Cell Proliferation                20 (38%)     22 (41%)     13 (25%)     18 (34%)     16 (30%)     14 (27%)     
      Hepatodiaphragmatic Nodule                                                                           1 (2%)       1 (2%)      
      Hyperplasia, Nodular                                                                                 1 (2%)                   
      Inflammation                                    44 (83%)     39 (72%)     44 (83%)     47 (89%)     48 (91%)     45 (88%)     
      Mixed Cell Focus                                 8 (15%)      3 (6%)       7 (13%)      6 (11%)      5 (9%)       3 (6%)      
      Mixed Cell Focus, Multiple                      21 (40%)     16 (30%)     22 (42%)     19 (36%)     19 (36%)     12 (24%)     
      Necrosis                                         7 (13%)      7 (13%)      7 (13%)      5 (9%)      12 (23%)     10 (20%)     
      Pigmentation                                     1 (2%)       1 (2%)       2 (4%)       5 (9%)       5 (9%)       9 (18%)     
      Bile Duct, Cyst                                  3 (6%)       2 (4%)       2 (4%)       3 (6%)       5 (9%)       2 (4%)      
      Bile Duct, Fibrosis                              2 (4%)       1 (2%)       2 (4%)       2 (4%)       2 (4%)       3 (6%)      
      Bile Duct, Hyperplasia                           5 (9%)       3 (6%)       2 (4%)      14 (26%)     10 (19%)     17 (33%)     
      Centrilobular, Degeneration                      2 (4%)      10 (19%)      4 (8%)       2 (4%)       2 (4%)       5 (10%)     
      Hepatocyte, Hypertrophy                                       5 (9%)       5 (9%)      24 (45%)     39 (74%)     41 (80%)     
      Oval Cell, Hyperplasia                                                                  1 (2%)                    4 (8%)      
      Serosa, Fibrosis                                                                                                  1 (2%)      
      Serosa, Inflammation                                                       2 (4%)                                             
   Mesentery                                                                    (1)                       (1)                       
      Fat, Inflammation, Chronic Active                                          1 (100%)                                           
   Oral Mucosa                                        (21)         (12)         (16)         (12)         (16)         (25)         
      Gingival, Hyperplasia, Squamous                 21 (100%)    10 (83%)     16 (100%)    11 (92%)     16 (100%)    25 (100%)    
   Pancreas                                           (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                                       1 (2%)                                             
      Degeneration                                                  1 (2%)                                                          
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)       1 (2%)                    2 (4%)      
      Acinus, Atrophy                                  1 (2%)                    1 (2%)       1 (2%)                    2 (4%)      
      Acinus, Hyperplasia                              3 (6%)                                                                       
      Acinus, Vacuolization Cytoplasmic                                                       1 (2%)       1 (2%)       2 (4%)      
   Salivary Glands                                    (51)         (52)         (53)         (52)         (53)         (51)         
      Ectopic Tissue                                                                          1 (2%)                                
   Stomach, Forestomach                               (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperkeratosis                                                1 (2%)                                 1 (2%)       2 (4%)      
      Hyperplasia, Squamous                            3 (6%)       4 (7%)       2 (4%)       6 (11%)      4 (8%)       4 (8%)      
      Inflammation                                                                            3 (6%)       3 (6%)       2 (4%)      
      Mineralization                                                1 (2%)                    2 (4%)       2 (4%)                   
      Ulcer                                                                                   2 (4%)       3 (6%)       1 (2%)      
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Stomach, Glandular                                 (53)         (54)         (53)         (53)         (53)         (51)         
      Erosion                                          1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation                                                                            2 (4%)                                
      Mineralization                                   5 (9%)       8 (15%)      8 (15%)     10 (19%)     10 (19%)      2 (4%)      
   Tooth                                              (34)         (13)         (19)         (22)         (23)         (35)         
      Degeneration                                     1 (3%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Peridontal Tissue, Inflammation                 33 (97%)     13 (100%)    19 (100%)    21 (95%)     23 (100%)    35 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (52)         (54)         (53)         (53)         (53)         (51)         
      Aorta, Mineralization                            2 (4%)       1 (2%)                    1 (2%)       1 (2%)                   
   Heart                                              (52)         (54)         (53)         (53)         (53)         (51)         
      Cardiomyopathy                                  22 (42%)     18 (33%)     19 (36%)     19 (36%)     23 (43%)     24 (47%)     
      Inflammation                                                  2 (4%)                    1 (2%)                    1 (2%)      
      Mineralization                                   1 (2%)                                 1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Thrombosis                                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                     21 (40%)     23 (43%)     34 (64%)     25 (47%)     29 (55%)     21 (41%)     
      Atrophy                                                                                 1 (2%)       2 (4%)                   
      Degeneration, Cystic                             9 (17%)     12 (22%)     15 (28%)     13 (25%)     12 (23%)     13 (25%)     
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                    3 (6%)      
      Hyperplasia                                     18 (34%)     24 (44%)     27 (51%)     27 (51%)     28 (53%)     11 (22%)     
      Hypertrophy                                     48 (91%)     35 (65%)     45 (85%)     35 (66%)     42 (79%)     41 (80%)     
      Inflammation                                                                            1 (2%)                    1 (2%)      
      Mineralization                                                                          2 (4%)       1 (2%)                   
      Necrosis                                         1 (2%)       2 (4%)       1 (2%)       2 (4%)       3 (6%)       3 (6%)      
      Vacuolization Cytoplasmic                       10 (19%)      8 (15%)     14 (26%)     16 (30%)     12 (23%)     14 (27%)     
   Adrenal Medulla                                    (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Hyperplasia                                     18 (34%)     14 (26%)     19 (36%)     14 (26%)     20 (38%)     12 (24%)     
   Islets, Pancreatic                                 (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (49)         (46)         (50)         (47)         (46)         (48)         
      Angiectasis                                                                             1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia                                      2 (4%)                                 1 (2%)                    1 (2%)      
   Pituitary Gland                                    (53)         (54)         (53)         (53)         (53)         (50)         
      Angiectasis                                     15 (28%)     16 (30%)     20 (38%)     26 (49%)     28 (53%)     14 (28%)     
      Atypia Cellular                                                                         1 (2%)                                
      Cyst                                                                       1 (2%)                                 1 (2%)      
      Cytoplasmic Alteration                           2 (4%)                    1 (2%)                    1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                                                                            1 (2%)                   
      Pars Distalis, Hyperplasia                      23 (43%)     18 (33%)     22 (42%)     16 (30%)     23 (43%)     25 (50%)     
   Thyroid Gland                                      (51)         (52)         (53)         (53)         (53)         (51)         
      Angiectasis                                                   1 (2%)                                 1 (2%)                   
      C-Cell, Hyperplasia                             19 (37%)     17 (33%)     23 (43%)     17 (32%)     19 (36%)     16 (31%)     
      Follicular Cell, Hyperplasia                     1 (2%)                                              2 (4%)       2 (4%)      
      Follicular Cell, Hypertrophy                     5 (10%)      9 (17%)      9 (17%)     12 (23%)     10 (19%)     17 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (51)         (52)         (53)         (51)         (50)         
      Atrophy                                                                                 1 (2%)                                
      Inflammation                                    52 (98%)     45 (88%)     41 (79%)     48 (91%)     48 (94%)     46 (92%)     
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Duct, Cyst                                      49 (92%)     40 (78%)     36 (69%)     43 (81%)     45 (88%)     41 (82%)     
   Ovary                                              (53)         (53)         (53)         (53)         (53)         (50)         
      Atrophy                                         47 (89%)     43 (81%)     42 (79%)     38 (72%)     44 (83%)     39 (78%)     
      Cyst                                            14 (26%)      7 (13%)     17 (32%)     17 (32%)     16 (30%)     17 (34%)     
      Inflammation, Chronic Active                                               2 (4%)       1 (2%)       5 (9%)       7 (14%)     
      Necrosis                                                                   1 (2%)                                             
      Interstitial Cell, Hyperplasia                   1 (2%)                                                           1 (2%)      
   Oviduct                                            (50)         (38)         (44)         (35)         (39)         (45)         
      Cyst                                                          1 (3%)       2 (5%)       1 (3%)       1 (3%)                   
      Dilatation                                                                 1 (2%)                                 1 (2%)      
      Inflammation, Chronic Active                     1 (2%)                    2 (5%)       1 (3%)       5 (13%)      7 (16%)     
   Uterus                                             (53)         (54)         (53)         (53)         (53)         (50)         
      Adenomyosis                                      2 (4%)       1 (2%)                    1 (2%)                    1 (2%)      
      Angiectasis                                                   1 (2%)                                 1 (2%)                   
      Congestion                                                                              1 (2%)                                
      Cyst                                                                       1 (2%)       1 (2%)                                
      Hemorrhage                                                    2 (4%)                                                          
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       5 (9%)       4 (8%)       2 (4%)       8 (16%)     
      Inflammation, Suppurative                        5 (9%)       6 (11%)      6 (11%)      2 (4%)      16 (30%)      8 (16%)     
      Metaplasia, Squamous                            23 (43%)     29 (54%)     27 (51%)     17 (32%)     27 (51%)     32 (64%)     
      Thrombosis                                                                              1 (2%)       2 (4%)                   
      Ulcer                                                         1 (2%)                                                          
      Cervix, Hyperplasia, Stromal                     1 (2%)                                              2 (4%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cervix, Inflammation, Suppurative                1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                37 (70%)     29 (54%)     32 (60%)     28 (53%)     25 (47%)     21 (42%)     
      Endometrium, Hyperplasia, Stromal                                                                    1 (2%)                   
   Vagina                                             (1)          (3)          (2)          (1)          (1)          (3)          
      Inflammation                                                               1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperplasia                                     34 (64%)     41 (76%)     40 (75%)     38 (72%)     42 (79%)     46 (90%)     
   Lymph Node                                         (3)          (3)          (3)          (2)          (5)          (6)          
      Hemorrhage                                                                 1 (33%)                                            
      Hyperplasia, Lymphoid                                                      1 (33%)                                            
      Hyperplasia, Plasma Cell                                      1 (33%)      1 (33%)                                            
      Iliac, Ectasia                                                                                       1 (20%)                  
      Iliac, Hyperplasia, Plasma Cell                                                                      1 (20%)                  
      Lumbar, Ectasia                                               1 (33%)      2 (67%)                                2 (33%)     
      Lumbar, Hemorrhage                                                         1 (33%)                                1 (17%)     
      Lumbar, Hyperplasia, Histiocytic                                                                     1 (20%)                  
      Lumbar, Hyperplasia, Plasma Cell                                                                     1 (20%)      2 (33%)     
      Mediastinal, Congestion                          3 (100%)                                                                     
      Mediastinal, Ectasia                                                                                              2 (33%)     
      Mediastinal, Hyperplasia, Histiocytic            1 (33%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 (33%)      1 (33%)                                                         
      Mediastinal, Hyperplasia, Plasma Cell            1 (33%)      1 (33%)                                                         
      Renal, Ectasia                                                                                                    2 (33%)     
      Renal, Hyperplasia, Plasma Cell                                                                                   1 (17%)     
      Renal, Inflammation, Chronic Active                                                     1 (50%)                               
   Lymph Node, Mandibular                             (51)         (52)         (53)         (51)         (53)         (51)         
      Congestion                                                                                           1 (2%)                   
      Ectasia                                                                    1 (2%)                    1 (2%)       1 (2%)      
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       2 (4%)       1 (2%)       3 (6%)       1 (2%)      
      Hyperplasia, Plasma Cell                        37 (73%)     36 (69%)     30 (57%)     33 (65%)     37 (70%)     38 (75%)     
      Inflammation                                                                                                      1 (2%)      
   Lymph Node, Mesenteric                             (52)         (54)         (53)         (53)         (53)         (51)         
      Ectasia                                                       1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Plasma Cell                                                                                          1 (2%)      
      Inflammation, Chronic Active                                                                                      1 (2%)      
   Spleen                                             (53)         (54)         (53)         (53)         (53)         (51)         
      Hematopoietic Cell Proliferation                46 (87%)     48 (89%)     52 (98%)     48 (91%)     46 (87%)     47 (92%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                                                                                        1 (2%)      
      Infarct                                                                                                           1 (2%)      
      Necrosis                                                      1 (2%)       1 (2%)                                 1 (2%)      
      Pigmentation                                    47 (89%)     42 (78%)     47 (89%)     49 (92%)     49 (92%)     46 (90%)     
      Lymphoid Follicle, Atrophy                       1 (2%)       6 (11%)      2 (4%)       3 (6%)       3 (6%)       3 (6%)      
      Red Pulp, Atrophy                                                                       2 (4%)                                
   Thymus                                             (48)         (53)         (52)         (53)         (53)         (47)         
      Atrophy                                         38 (79%)     38 (72%)     37 (71%)     35 (66%)     41 (77%)     30 (64%)     
      Cyst                                                          1 (2%)                                              1 (2%)      
      Hemorrhage                                                    3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                             2 (4%)       1 (2%)                    2 (4%)       1 (2%)       3 (6%)      
      Hyperplasia                                     22 (42%)     23 (43%)     32 (60%)     27 (51%)     32 (60%)     22 (43%)     
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Granulomatous                                   2 (4%)       2 (4%)       3 (6%)                    1 (2%)      
   Skin                                               (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                                                                              1 (2%)      
      Cyst Epithelial Inclusion                                     1 (2%)                                 1 (2%)                   
      Inflammation                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (54)         (53)         (53)         (53)         (51)         
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)       2 (4%)                   
      Hydrocephalus                                                                           2 (4%)       1 (2%)                   
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Vacuolization Cytoplasmic                                                                                         1 (2%)      
      Glial Cell, Hyperplasia                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (52)         (54)         (53)         (53)         (53)         (51)         
      Congestion                                                                                           1 (2%)                   
      Hemorrhage                                       1 (2%)                                                           1 (2%)      
      Infiltration Cellular, Histiocyte               45 (87%)     40 (74%)     40 (75%)     40 (75%)     27 (51%)     28 (55%)     
      Inflammation                                     6 (12%)      7 (13%)      2 (4%)       6 (11%)      7 (13%)      9 (18%)     
      Metaplasia, Squamous                                                                    1 (2%)       1 (2%)       1 (2%)      
      Mineralization                                                                          1 (2%)       1 (2%)                   
      Alveolar Epithelium, Hyperplasia                20 (38%)     21 (39%)     16 (30%)     11 (21%)      9 (17%)      6 (12%)     
      Mediastinum, Hemorrhage                                                                 1 (2%)                                
      Serosa, Inflammation, Chronic Active                                                    1 (2%)                                
   Nose                                               (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                          1 (2%)                                                          
      Inflammation                                     1 (2%)       6 (11%)      3 (6%)       6 (11%)      6 (11%)      3 (6%)      
      Goblet Cell, Hyperplasia                                                   2 (4%)       1 (2%)       2 (4%)                   
      Nasolacrimal Duct, Inflammation                  2 (4%)                                                           2 (4%)      
      Respiratory Epithelium, Hyperplasia                                        2 (4%)                    1 (2%)                   
      Respiratory Epithelium, Mineralization                        1 (2%)                                                          
      Septum, Inflammation                             4 (8%)       3 (6%)       5 (9%)       3 (6%)       7 (13%)      6 (12%)     
      Squamous Epithelium, Hyperplasia                              1 (2%)                                                          
      Turbinate, Inflammation                          8 (15%)      3 (6%)       5 (9%)       9 (17%)     10 (19%)     10 (20%)     
   Trachea                                            (52)         (54)         (53)         (53)         (53)         (51)         
      Inflammation                                                                                                      1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (53)         (54)         (53)         (53)         (52)         (51)         
      Degeneration                                     1 (2%)                                                                       
      Anterior Chamber, Exudate                                                                            1 (2%)                   
      Lens, Degeneration                                                                      1 (2%)                                
      Retina, Atrophy                                  2 (4%)                    1 (2%)                    1 (2%)                   
   Harderian Gland                                    (53)         (54)         (53)         (53)         (53)         (49)         
      Atrophy                                                       1 (2%)                                                          
      Inflammation                                    20 (38%)      9 (17%)     13 (25%)     16 (30%)     16 (30%)     16 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (54)         (53)         (53)         (53)         (51)         
      Accumulation, Hyaline Droplet                                 3 (6%)       1 (2%)                                 1 (2%)      
      Calculus Micro Observation Only                  3 (6%)       5 (9%)       4 (8%)       7 (13%)      5 (9%)       1 (2%)      
      Casts Protein                                    3 (6%)       2 (4%)       2 (4%)       1 (2%)                    1 (2%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cyst                                             1 (2%)                                 1 (2%)                                
      Degeneration                                                               1 (2%)                                             
      Hydronephrosis                                                             1 (2%)                    1 (2%)                   
      Infarct                                          1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                                  2 (4%)                                 3 (6%)       1 (2%)      
      Inflammation, Suppurative                        1 (2%)       2 (4%)       3 (6%)       2 (4%)       2 (4%)       3 (6%)      
      Mineralization                                  40 (75%)     42 (78%)     41 (77%)     39 (74%)     40 (75%)     41 (80%)     
      Necrosis                                                      1 (2%)                                                          
      Nephropathy                                     34 (64%)     23 (43%)     24 (45%)     33 (62%)     28 (53%)     34 (67%)     
      Pelvis, Dilatation                                            2 (4%)                                                          
      Pelvis, Inflammation                             1 (2%)       4 (7%)       2 (4%)       4 (8%)       5 (9%)       4 (8%)      
      Renal Tubule, Degeneration                                                 1 (2%)                                 1 (2%)      
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             1 (2%)       5 (9%)       2 (4%)       4 (8%)       6 (11%)      4 (8%)      
   Ureter                                                                       (1)                                                 
      Cyst                                                                       1 (100%)                                           
   Urinary Bladder                                    (53)         (53)         (53)         (53)         (53)         (50)         
      Calculus Micro Observation Only                               1 (2%)                                                          
      Inflammation                                     8 (15%)     11 (21%)      6 (11%)      8 (15%)     13 (25%)      9 (18%)     
      Transitional Epithelium, Hyperplasia                          3 (6%)       2 (4%)       3 (6%)       2 (4%)       3 (6%)      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50                                                                            
  Early Deaths                                                                                                                      
    Natural Death                                     14                                                                            
    Moribund Sacrifice                                16                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                20                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)                                                                          
      Muscularis, Inflammation                         3 (6%)                                                                       
   Intestine Large, Rectum                            (50)                                                                          
      Parasite Metazoan                                3 (6%)                                                                       
   Intestine Large, Cecum                             (48)                                                                          
      Inflammation                                     1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)                                                                          
      Angiectasis                                      8 (16%)                                                                      
      Basophilic Focus                                 8 (16%)                                                                      
      Basophilic Focus, Multiple                       2 (4%)                                                                       
      Clear Cell Focus                                 1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)                                                                       
      Eosinophilic Focus                               4 (8%)                                                                       
      Eosinophilic Focus, Multiple                    10 (20%)                                                                      
      Fatty Change, Diffuse                           15 (30%)                                                                      
      Fatty Change, Focal                              6 (12%)                                                                      
      Hematopoietic Cell Proliferation                17 (34%)                                                                      
      Hepatodiaphragmatic Nodule                       2 (4%)                                                                       
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Nodular                             1 (2%)                                                                       
      Inflammation                                    44 (88%)                                                                      
      Mixed Cell Focus                                 7 (14%)                                                                      
      Mixed Cell Focus, Multiple                      13 (26%)                                                                      
      Necrosis                                         9 (18%)                                                                      
      Pigmentation                                     3 (6%)                                                                       
      Bile Duct, Cyst                                  3 (6%)                                                                       
      Bile Duct, Fibrosis                              5 (10%)                                                                      
      Bile Duct, Hyperplasia                          12 (24%)                                                                      
      Centrilobular, Degeneration                      5 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hypertrophy                         32 (64%)                                                                      
      Oval Cell, Hyperplasia                           2 (4%)                                                                       
   Oral Mucosa                                        (15)                                                                          
      Gingival, Hyperplasia, Squamous                 15 (100%)                                                                     
   Pancreas                                           (50)                                                                          
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Acinus, Atrophy                                  3 (6%)                                                                       
      Acinus, Hyperplasia                              2 (4%)                                                                       
      Acinus, Vacuolization Cytoplasmic                1 (2%)                                                                       
   Salivary Glands                                    (48)                                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Stomach, Forestomach                               (50)                                                                          
      Hyperkeratosis                                   2 (4%)                                                                       
      Hyperplasia, Squamous                            5 (10%)                                                                      
      Inflammation                                     4 (8%)                                                                       
      Mineralization                                   3 (6%)                                                                       
   Stomach, Glandular                                 (50)                                                                          
      Inflammation                                     1 (2%)                                                                       
      Mineralization                                   3 (6%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Serosa, Inflammation                             1 (2%)                                                                       
   Tooth                                              (27)                                                                          
      Peridontal Tissue, Inflammation                 27 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                                                                          
      Cardiomyopathy                                  15 (30%)                                                                      
      Epicardium, Inflammation                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)                                                                          
      Angiectasis                                     20 (40%)                                                                      
      Degeneration, Cystic                             7 (14%)                                                                      
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hyperplasia                                     18 (36%)                                                                      
      Hypertrophy                                     35 (70%)                                                                      
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                       12 (24%)                                                                      
   Adrenal Medulla                                    (50)                                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                     19 (38%)                                                                      
   Parathyroid Gland                                  (45)                                                                          
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)                                                                          
      Angiectasis                                     24 (48%)                                                                      
      Pars Distalis, Hyperplasia                      18 (36%)                                                                      
      Rathke's Cleft, Pars Nervosa, Cyst               1 (2%)                                                                       
   Thyroid Gland                                      (49)                                                                          
      C-Cell, Hyperplasia                             13 (27%)                                                                      
      Follicular Cell, Hypertrophy                    12 (24%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)                                                                          
      Inflammation                                    44 (92%)                                                                      
      Duct, Cyst                                      41 (85%)                                                                      
   Ovary                                              (49)                                                                          
      Atrophy                                         41 (84%)                                                                      
      Cyst                                            16 (33%)                                                                      
   Oviduct                                            (46)                                                                          
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
   Uterus                                             (49)                                                                          
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                        9 (18%)                                                                      
      Metaplasia, Squamous                            24 (49%)                                                                      
      Cervix, Cyst                                     1 (2%)                                                                       
      Cervix, Hyperplasia, Stromal                     2 (4%)                                                                       
      Endometrium, Hyperplasia, Cystic                23 (47%)                                                                      
   Vagina                                             (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)                                                                          
      Hyperplasia                                     40 (80%)                                                                      
   Lymph Node                                         (1)                                                                           
      Mediastinal, Hemorrhage                          1 (100%)                                                                     
   Lymph Node, Mandibular                             (48)                                                                          
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                        37 (77%)                                                                      
      Inflammation                                     1 (2%)                                                                       
   Spleen                                             (50)                                                                          
      Accessory Spleen                                 1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                44 (88%)                                                                      
      Hemorrhage                                       1 (2%)                                                                       
      Pigmentation                                    50 (100%)                                                                     
      Lymphoid Follicle, Atrophy                       4 (8%)                                                                       
   Thymus                                             (49)                                                                          
      Atrophy                                         29 (59%)                                                                      
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
      Necrosis, Lymphoid                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                                                          
      Cyst                                             3 (6%)                                                                       
      Cyst, Multiple                                   1 (2%)                                                                       
      Hyperplasia                                     27 (54%)                                                                      
      Inflammation, Granulomatous                      2 (4%)                                                                       
   Skin                                               (50)                                                                          
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               37 (74%)                                                                      
      Inflammation                                     9 (18%)                                                                      
      Alveolar Epithelium, Hyperplasia                 4 (8%)                                                                       
   Nose                                               (50)                                                                          
      Inflammation                                     2 (4%)                                                                       
      Septum, Inflammation                             4 (8%)                                                                       
      Turbinate, Inflammation                          5 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)                                                                          
      Retina, Atrophy                                  2 (4%)                                                                       
   Harderian Gland                                    (50)                                                                          
      Inflammation                                    15 (30%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)                                                                          
      Casts Protein                                    4 (8%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                                                                       
      Inflammation, Suppurative                        2 (4%)                                                                       
      Mineralization                                  38 (76%)                                                                      
      Nephropathy                                     22 (44%)                                                                      
      Pelvis, Inflammation                             3 (6%)                                                                       
      Transitional Epithelium, Hyperplasia             4 (8%)                                                                       
   Urinary Bladder                                    (49)                                                                          
      Inflammation                                    10 (20%)                                                                      
      Transitional Epithelium, Hyperplasia             3 (6%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------