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TDMS Study 96021-01 Pathology Tables


NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03
Route: GAVAGE                                                                                                     Time: 09:34:31

                                                            FINAL #3




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  35065-27-1

       Lock Date:  01/16/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           98           98           80           
  Early Deaths                                                                                                                      
    Natural Death                                     11           15            8            9           15           11           
    Moribund Sacrifice                                18           23           17           22           18           19           
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           16           28           20           20           21           
    Natural Death                                                                             1                                     
                                                                                                                                    
  Animals Examined Microscopically                    53           54           53           53           53           51           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (54)         (53)         (53)         (53)         (51)         
      Muscularis, Inflammation                                      3 (6%)                    1 (2%)       2 (4%)       1 (2%)      
      Periesophageal Tissue, Hemorrhage                                                       1 (2%)                                
      Periesophageal Tissue, Inflammation                                                     1 (2%)                                
   Intestine Large, Colon                             (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Parasite Metazoan                                             1 (2%)       1 (2%)                    1 (2%)       2 (4%)      
   Intestine Large, Rectum                            (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Parasite Metazoan                                1 (2%)       2 (4%)       3 (6%)       7 (13%)      5 (9%)       5 (10%)     
   Intestine Large, Cecum                             (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 (2%)      
   Intestine Small, Duodenum                          (53)         (54)         (53)         (53)         (53)         (51)         
      Parasite Metazoan                                                                                                 1 (2%)      
   Intestine Small, Jejunum                           (53)         (54)         (53)         (53)         (53)         (50)         
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                           1 (2%)      
   Intestine Small, Ileum                             (52)         (54)         (53)         (53)         (53)         (50)         
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                      5 (9%)       2 (4%)       2 (4%)       1 (2%)       8 (15%)      4 (8%)      
      Basophilic Focus                                 8 (15%)      5 (9%)      16 (30%)      6 (11%)      3 (6%)       8 (16%)     
      Basophilic Focus, Multiple                       8 (15%)     12 (22%)      9 (17%)      7 (13%)      7 (13%)      2 (4%)      
      Cholangiofibrosis                                                                                    1 (2%)                   
      Clear Cell Focus                                 3 (6%)       3 (6%)       4 (8%)                                 2 (4%)      
      Clear Cell Focus, Multiple                       3 (6%)       2 (4%)       1 (2%)                                             
      Eosinophilic Focus                               5 (9%)       1 (2%)       8 (15%)      7 (13%)     14 (26%)      6 (12%)     
      Eosinophilic Focus, Multiple                     7 (13%)      1 (2%)       8 (15%)     12 (23%)      9 (17%)     12 (24%)     
      Fatty Change, Diffuse                            3 (6%)       7 (13%)      2 (4%)      11 (21%)     21 (40%)     17 (33%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change, Focal                              4 (8%)                    3 (6%)       5 (9%)       4 (8%)       1 (2%)      
      Hematopoietic Cell Proliferation                20 (38%)     22 (41%)     13 (25%)     18 (34%)     16 (30%)     14 (27%)     
      Hepatodiaphragmatic Nodule                                                                           1 (2%)       1 (2%)      
      Hyperplasia, Nodular                                                                                 1 (2%)                   
      Inflammation                                    44 (83%)     39 (72%)     44 (83%)     47 (89%)     48 (91%)     45 (88%)     
      Mixed Cell Focus                                 8 (15%)      3 (6%)       7 (13%)      6 (11%)      5 (9%)       3 (6%)      
      Mixed Cell Focus, Multiple                      21 (40%)     16 (30%)     22 (42%)     19 (36%)     19 (36%)     12 (24%)     
      Necrosis                                         7 (13%)      7 (13%)      7 (13%)      5 (9%)      12 (23%)     10 (20%)     
      Pigmentation                                     1 (2%)       1 (2%)       2 (4%)       5 (9%)       5 (9%)       9 (18%)     
      Bile Duct, Cyst                                  3 (6%)       2 (4%)       2 (4%)       3 (6%)       5 (9%)       2 (4%)      
      Bile Duct, Fibrosis                              2 (4%)       1 (2%)       2 (4%)       2 (4%)       2 (4%)       3 (6%)      
      Bile Duct, Hyperplasia                           5 (9%)       3 (6%)       2 (4%)      14 (26%)     10 (19%)     17 (33%)     
      Centrilobular, Degeneration                      2 (4%)      10 (19%)      4 (8%)       2 (4%)       2 (4%)       5 (10%)     
      Hepatocyte, Hypertrophy                                       5 (9%)       5 (9%)      24 (45%)     39 (74%)     41 (80%)     
      Oval Cell, Hyperplasia                                                                  1 (2%)                    4 (8%)      
      Serosa, Fibrosis                                                                                                  1 (2%)      
      Serosa, Inflammation                                                       2 (4%)                                             
   Mesentery                                                                    (1)                       (1)                       
      Fat, Inflammation, Chronic Active                                          1 (100%)                                           
   Oral Mucosa                                        (21)         (12)         (16)         (12)         (16)         (25)         
      Gingival, Hyperplasia, Squamous                 21 (100%)    10 (83%)     16 (100%)    11 (92%)     16 (100%)    25 (100%)    
   Pancreas                                           (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                                       1 (2%)                                             
      Degeneration                                                  1 (2%)                                                          
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)       1 (2%)                    2 (4%)      
      Acinus, Atrophy                                  1 (2%)                    1 (2%)       1 (2%)                    2 (4%)      
      Acinus, Hyperplasia                              3 (6%)                                                                       
      Acinus, Vacuolization Cytoplasmic                                                       1 (2%)       1 (2%)       2 (4%)      
   Salivary Glands                                    (51)         (52)         (53)         (52)         (53)         (51)         
      Ectopic Tissue                                                                          1 (2%)                                
   Stomach, Forestomach                               (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperkeratosis                                                1 (2%)                                 1 (2%)       2 (4%)      
      Hyperplasia, Squamous                            3 (6%)       4 (7%)       2 (4%)       6 (11%)      4 (8%)       4 (8%)      
      Inflammation                                                                            3 (6%)       3 (6%)       2 (4%)      
      Mineralization                                                1 (2%)                    2 (4%)       2 (4%)                   
      Ulcer                                                                                   2 (4%)       3 (6%)       1 (2%)      
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Stomach, Glandular                                 (53)         (54)         (53)         (53)         (53)         (51)         
      Erosion                                          1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation                                                                            2 (4%)                                
      Mineralization                                   5 (9%)       8 (15%)      8 (15%)     10 (19%)     10 (19%)      2 (4%)      
   Tooth                                              (34)         (13)         (19)         (22)         (23)         (35)         
      Degeneration                                     1 (3%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Peridontal Tissue, Inflammation                 33 (97%)     13 (100%)    19 (100%)    21 (95%)     23 (100%)    35 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (52)         (54)         (53)         (53)         (53)         (51)         
      Aorta, Mineralization                            2 (4%)       1 (2%)                    1 (2%)       1 (2%)                   
   Heart                                              (52)         (54)         (53)         (53)         (53)         (51)         
      Cardiomyopathy                                  22 (42%)     18 (33%)     19 (36%)     19 (36%)     23 (43%)     24 (47%)     
      Inflammation                                                  2 (4%)                    1 (2%)                    1 (2%)      
      Mineralization                                   1 (2%)                                 1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Thrombosis                                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                     21 (40%)     23 (43%)     34 (64%)     25 (47%)     29 (55%)     21 (41%)     
      Atrophy                                                                                 1 (2%)       2 (4%)                   
      Degeneration, Cystic                             9 (17%)     12 (22%)     15 (28%)     13 (25%)     12 (23%)     13 (25%)     
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                    3 (6%)      
      Hyperplasia                                     18 (34%)     24 (44%)     27 (51%)     27 (51%)     28 (53%)     11 (22%)     
      Hypertrophy                                     48 (91%)     35 (65%)     45 (85%)     35 (66%)     42 (79%)     41 (80%)     
      Inflammation                                                                            1 (2%)                    1 (2%)      
      Mineralization                                                                          2 (4%)       1 (2%)                   
      Necrosis                                         1 (2%)       2 (4%)       1 (2%)       2 (4%)       3 (6%)       3 (6%)      
      Vacuolization Cytoplasmic                       10 (19%)      8 (15%)     14 (26%)     16 (30%)     12 (23%)     14 (27%)     
   Adrenal Medulla                                    (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Hyperplasia                                     18 (34%)     14 (26%)     19 (36%)     14 (26%)     20 (38%)     12 (24%)     
   Islets, Pancreatic                                 (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (49)         (46)         (50)         (47)         (46)         (48)         
      Angiectasis                                                                             1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia                                      2 (4%)                                 1 (2%)                    1 (2%)      
   Pituitary Gland                                    (53)         (54)         (53)         (53)         (53)         (50)         
      Angiectasis                                     15 (28%)     16 (30%)     20 (38%)     26 (49%)     28 (53%)     14 (28%)     
      Atypia Cellular                                                                         1 (2%)                                
      Cyst                                                                       1 (2%)                                 1 (2%)      
      Cytoplasmic Alteration                           2 (4%)                    1 (2%)                    1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                                                                            1 (2%)                   
      Pars Distalis, Hyperplasia                      23 (43%)     18 (33%)     22 (42%)     16 (30%)     23 (43%)     25 (50%)     
   Thyroid Gland                                      (51)         (52)         (53)         (53)         (53)         (51)         
      Angiectasis                                                   1 (2%)                                 1 (2%)                   
      C-Cell, Hyperplasia                             19 (37%)     17 (33%)     23 (43%)     17 (32%)     19 (36%)     16 (31%)     
      Follicular Cell, Hyperplasia                     1 (2%)                                              2 (4%)       2 (4%)      
      Follicular Cell, Hypertrophy                     5 (10%)      9 (17%)      9 (17%)     12 (23%)     10 (19%)     17 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (51)         (52)         (53)         (51)         (50)         
      Atrophy                                                                                 1 (2%)                                
      Inflammation                                    52 (98%)     45 (88%)     41 (79%)     48 (91%)     48 (94%)     46 (92%)     
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Duct, Cyst                                      49 (92%)     40 (78%)     36 (69%)     43 (81%)     45 (88%)     41 (82%)     
   Ovary                                              (53)         (53)         (53)         (53)         (53)         (50)         
      Atrophy                                         47 (89%)     43 (81%)     42 (79%)     38 (72%)     44 (83%)     39 (78%)     
      Cyst                                            14 (26%)      7 (13%)     17 (32%)     17 (32%)     16 (30%)     17 (34%)     
      Inflammation, Chronic Active                                               2 (4%)       1 (2%)       5 (9%)       7 (14%)     
      Necrosis                                                                   1 (2%)                                             
      Interstitial Cell, Hyperplasia                   1 (2%)                                                           1 (2%)      
   Oviduct                                            (50)         (38)         (44)         (35)         (39)         (45)         
      Cyst                                                          1 (3%)       2 (5%)       1 (3%)       1 (3%)                   
      Dilatation                                                                 1 (2%)                                 1 (2%)      
      Inflammation, Chronic Active                     1 (2%)                    2 (5%)       1 (3%)       5 (13%)      7 (16%)     
   Uterus                                             (53)         (54)         (53)         (53)         (53)         (50)         
      Adenomyosis                                      2 (4%)       1 (2%)                    1 (2%)                    1 (2%)      
      Angiectasis                                                   1 (2%)                                 1 (2%)                   
      Congestion                                                                              1 (2%)                                
      Cyst                                                                       1 (2%)       1 (2%)                                
      Hemorrhage                                                    2 (4%)                                                          
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       5 (9%)       4 (8%)       2 (4%)       8 (16%)     
      Inflammation, Suppurative                        5 (9%)       6 (11%)      6 (11%)      2 (4%)      16 (30%)      8 (16%)     
      Metaplasia, Squamous                            23 (43%)     29 (54%)     27 (51%)     17 (32%)     27 (51%)     32 (64%)     
      Thrombosis                                                                              1 (2%)       2 (4%)                   
      Ulcer                                                         1 (2%)                                                          
      Cervix, Hyperplasia, Stromal                     1 (2%)                                              2 (4%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cervix, Inflammation, Suppurative                1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                37 (70%)     29 (54%)     32 (60%)     28 (53%)     25 (47%)     21 (42%)     
      Endometrium, Hyperplasia, Stromal                                                                    1 (2%)                   
   Vagina                                             (1)          (3)          (2)          (1)          (1)          (3)          
      Inflammation                                                               1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperplasia                                     34 (64%)     41 (76%)     40 (75%)     38 (72%)     42 (79%)     46 (90%)     
   Lymph Node                                         (3)          (3)          (3)          (2)          (5)          (6)          
      Hemorrhage                                                                 1 (33%)                                            
      Hyperplasia, Lymphoid                                                      1 (33%)                                            
      Hyperplasia, Plasma Cell                                      1 (33%)      1 (33%)                                            
      Iliac, Ectasia                                                                                       1 (20%)                  
      Iliac, Hyperplasia, Plasma Cell                                                                      1 (20%)                  
      Lumbar, Ectasia                                               1 (33%)      2 (67%)                                2 (33%)     
      Lumbar, Hemorrhage                                                         1 (33%)                                1 (17%)     
      Lumbar, Hyperplasia, Histiocytic                                                                     1 (20%)                  
      Lumbar, Hyperplasia, Plasma Cell                                                                     1 (20%)      2 (33%)     
      Mediastinal, Congestion                          3 (100%)                                                                     
      Mediastinal, Ectasia                                                                                              2 (33%)     
      Mediastinal, Hyperplasia, Histiocytic            1 (33%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 (33%)      1 (33%)                                                         
      Mediastinal, Hyperplasia, Plasma Cell            1 (33%)      1 (33%)                                                         
      Renal, Ectasia                                                                                                    2 (33%)     
      Renal, Hyperplasia, Plasma Cell                                                                                   1 (17%)     
      Renal, Inflammation, Chronic Active                                                     1 (50%)                               
   Lymph Node, Mandibular                             (51)         (52)         (53)         (51)         (53)         (51)         
      Congestion                                                                                           1 (2%)                   
      Ectasia                                                                    1 (2%)                    1 (2%)       1 (2%)      
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       2 (4%)       1 (2%)       3 (6%)       1 (2%)      
      Hyperplasia, Plasma Cell                        37 (73%)     36 (69%)     30 (57%)     33 (65%)     37 (70%)     38 (75%)     
      Inflammation                                                                                                      1 (2%)      
   Lymph Node, Mesenteric                             (52)         (54)         (53)         (53)         (53)         (51)         
      Ectasia                                                       1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Plasma Cell                                                                                          1 (2%)      
      Inflammation, Chronic Active                                                                                      1 (2%)      
   Spleen                                             (53)         (54)         (53)         (53)         (53)         (51)         
      Hematopoietic Cell Proliferation                46 (87%)     48 (89%)     52 (98%)     48 (91%)     46 (87%)     47 (92%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                                                                                        1 (2%)      
      Infarct                                                                                                           1 (2%)      
      Necrosis                                                      1 (2%)       1 (2%)                                 1 (2%)      
      Pigmentation                                    47 (89%)     42 (78%)     47 (89%)     49 (92%)     49 (92%)     46 (90%)     
      Lymphoid Follicle, Atrophy                       1 (2%)       6 (11%)      2 (4%)       3 (6%)       3 (6%)       3 (6%)      
      Red Pulp, Atrophy                                                                       2 (4%)                                
   Thymus                                             (48)         (53)         (52)         (53)         (53)         (47)         
      Atrophy                                         38 (79%)     38 (72%)     37 (71%)     35 (66%)     41 (77%)     30 (64%)     
      Cyst                                                          1 (2%)                                              1 (2%)      
      Hemorrhage                                                    3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                             2 (4%)       1 (2%)                    2 (4%)       1 (2%)       3 (6%)      
      Hyperplasia                                     22 (42%)     23 (43%)     32 (60%)     27 (51%)     32 (60%)     22 (43%)     
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Granulomatous                                   2 (4%)       2 (4%)       3 (6%)                    1 (2%)      
   Skin                                               (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                                                                              1 (2%)      
      Cyst Epithelial Inclusion                                     1 (2%)                                 1 (2%)                   
      Inflammation                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (54)         (53)         (53)         (53)         (51)         
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)       2 (4%)                   
      Hydrocephalus                                                                           2 (4%)       1 (2%)                   
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Vacuolization Cytoplasmic                                                                                         1 (2%)      
      Glial Cell, Hyperplasia                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (52)         (54)         (53)         (53)         (53)         (51)         
      Congestion                                                                                           1 (2%)                   
      Hemorrhage                                       1 (2%)                                                           1 (2%)      
      Infiltration Cellular, Histiocyte               45 (87%)     40 (74%)     40 (75%)     40 (75%)     27 (51%)     28 (55%)     
      Inflammation                                     6 (12%)      7 (13%)      2 (4%)       6 (11%)      7 (13%)      9 (18%)     
      Metaplasia, Squamous                                                                    1 (2%)       1 (2%)       1 (2%)      
      Mineralization                                                                          1 (2%)       1 (2%)                   
      Alveolar Epithelium, Hyperplasia                20 (38%)     21 (39%)     16 (30%)     11 (21%)      9 (17%)      6 (12%)     
      Mediastinum, Hemorrhage                                                                 1 (2%)                                
      Serosa, Inflammation, Chronic Active                                                    1 (2%)                                
   Nose                                               (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                          1 (2%)                                                          
      Inflammation                                     1 (2%)       6 (11%)      3 (6%)       6 (11%)      6 (11%)      3 (6%)      
      Goblet Cell, Hyperplasia                                                   2 (4%)       1 (2%)       2 (4%)                   
      Nasolacrimal Duct, Inflammation                  2 (4%)                                                           2 (4%)      
      Respiratory Epithelium, Hyperplasia                                        2 (4%)                    1 (2%)                   
      Respiratory Epithelium, Mineralization                        1 (2%)                                                          
      Septum, Inflammation                             4 (8%)       3 (6%)       5 (9%)       3 (6%)       7 (13%)      6 (12%)     
      Squamous Epithelium, Hyperplasia                              1 (2%)                                                          
      Turbinate, Inflammation                          8 (15%)      3 (6%)       5 (9%)       9 (17%)     10 (19%)     10 (20%)     
   Trachea                                            (52)         (54)         (53)         (53)         (53)         (51)         
      Inflammation                                                                                                      1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (53)         (54)         (53)         (53)         (52)         (51)         
      Degeneration                                     1 (2%)                                                                       
      Anterior Chamber, Exudate                                                                            1 (2%)                   
      Lens, Degeneration                                                                      1 (2%)                                
      Retina, Atrophy                                  2 (4%)                    1 (2%)                    1 (2%)                   
   Harderian Gland                                    (53)         (54)         (53)         (53)         (53)         (49)         
      Atrophy                                                       1 (2%)                                                          
      Inflammation                                    20 (38%)      9 (17%)     13 (25%)     16 (30%)     16 (30%)     16 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (54)         (53)         (53)         (53)         (51)         
      Accumulation, Hyaline Droplet                                 3 (6%)       1 (2%)                                 1 (2%)      
      Calculus Micro Observation Only                  3 (6%)       5 (9%)       4 (8%)       7 (13%)      5 (9%)       1 (2%)      
      Casts Protein                                    3 (6%)       2 (4%)       2 (4%)       1 (2%)                    1 (2%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cyst                                             1 (2%)                                 1 (2%)                                
      Degeneration                                                               1 (2%)                                             
      Hydronephrosis                                                             1 (2%)                    1 (2%)                   
      Infarct                                          1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                                  2 (4%)                                 3 (6%)       1 (2%)      
      Inflammation, Suppurative                        1 (2%)       2 (4%)       3 (6%)       2 (4%)       2 (4%)       3 (6%)      
      Mineralization                                  40 (75%)     42 (78%)     41 (77%)     39 (74%)     40 (75%)     41 (80%)     
      Necrosis                                                      1 (2%)                                                          
      Nephropathy                                     34 (64%)     23 (43%)     24 (45%)     33 (62%)     28 (53%)     34 (67%)     
      Pelvis, Dilatation                                            2 (4%)                                                          
      Pelvis, Inflammation                             1 (2%)       4 (7%)       2 (4%)       4 (8%)       5 (9%)       4 (8%)      
      Renal Tubule, Degeneration                                                 1 (2%)                                 1 (2%)      
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             1 (2%)       5 (9%)       2 (4%)       4 (8%)       6 (11%)      4 (8%)      
   Ureter                                                                       (1)                                                 
      Cyst                                                                       1 (100%)                                           
   Urinary Bladder                                    (53)         (53)         (53)         (53)         (53)         (50)         
      Calculus Micro Observation Only                               1 (2%)                                                          
      Inflammation                                     8 (15%)     11 (21%)      6 (11%)      8 (15%)     13 (25%)      9 (18%)     
      Transitional Epithelium, Hyperplasia                          3 (6%)       2 (4%)       3 (6%)       2 (4%)       3 (6%)      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50                                                                            
  Early Deaths                                                                                                                      
    Natural Death                                     14                                                                            
    Moribund Sacrifice                                16                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                20                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)                                                                          
      Muscularis, Inflammation                         3 (6%)                                                                       
   Intestine Large, Rectum                            (50)                                                                          
      Parasite Metazoan                                3 (6%)                                                                       
   Intestine Large, Cecum                             (48)                                                                          
      Inflammation                                     1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)                                                                          
      Angiectasis                                      8 (16%)                                                                      
      Basophilic Focus                                 8 (16%)                                                                      
      Basophilic Focus, Multiple                       2 (4%)                                                                       
      Clear Cell Focus                                 1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)                                                                       
      Eosinophilic Focus                               4 (8%)                                                                       
      Eosinophilic Focus, Multiple                    10 (20%)                                                                      
      Fatty Change, Diffuse                           15 (30%)                                                                      
      Fatty Change, Focal                              6 (12%)                                                                      
      Hematopoietic Cell Proliferation                17 (34%)                                                                      
      Hepatodiaphragmatic Nodule                       2 (4%)                                                                       
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Nodular                             1 (2%)                                                                       
      Inflammation                                    44 (88%)                                                                      
      Mixed Cell Focus                                 7 (14%)                                                                      
      Mixed Cell Focus, Multiple                      13 (26%)                                                                      
      Necrosis                                         9 (18%)                                                                      
      Pigmentation                                     3 (6%)                                                                       
      Bile Duct, Cyst                                  3 (6%)                                                                       
      Bile Duct, Fibrosis                              5 (10%)                                                                      
      Bile Duct, Hyperplasia                          12 (24%)                                                                      
      Centrilobular, Degeneration                      5 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hypertrophy                         32 (64%)                                                                      
      Oval Cell, Hyperplasia                           2 (4%)                                                                       
   Oral Mucosa                                        (15)                                                                          
      Gingival, Hyperplasia, Squamous                 15 (100%)                                                                     
   Pancreas                                           (50)                                                                          
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Acinus, Atrophy                                  3 (6%)                                                                       
      Acinus, Hyperplasia                              2 (4%)                                                                       
      Acinus, Vacuolization Cytoplasmic                1 (2%)                                                                       
   Salivary Glands                                    (48)                                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Stomach, Forestomach                               (50)                                                                          
      Hyperkeratosis                                   2 (4%)                                                                       
      Hyperplasia, Squamous                            5 (10%)                                                                      
      Inflammation                                     4 (8%)                                                                       
      Mineralization                                   3 (6%)                                                                       
   Stomach, Glandular                                 (50)                                                                          
      Inflammation                                     1 (2%)                                                                       
      Mineralization                                   3 (6%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Serosa, Inflammation                             1 (2%)                                                                       
   Tooth                                              (27)                                                                          
      Peridontal Tissue, Inflammation                 27 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                                                                          
      Cardiomyopathy                                  15 (30%)                                                                      
      Epicardium, Inflammation                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)                                                                          
      Angiectasis                                     20 (40%)                                                                      
      Degeneration, Cystic                             7 (14%)                                                                      
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hyperplasia                                     18 (36%)                                                                      
      Hypertrophy                                     35 (70%)                                                                      
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                       12 (24%)                                                                      
   Adrenal Medulla                                    (50)                                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                     19 (38%)                                                                      
   Parathyroid Gland                                  (45)                                                                          
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)                                                                          
      Angiectasis                                     24 (48%)                                                                      
      Pars Distalis, Hyperplasia                      18 (36%)                                                                      
      Rathke's Cleft, Pars Nervosa, Cyst               1 (2%)                                                                       
   Thyroid Gland                                      (49)                                                                          
      C-Cell, Hyperplasia                             13 (27%)                                                                      
      Follicular Cell, Hypertrophy                    12 (24%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)                                                                          
      Inflammation                                    44 (92%)                                                                      
      Duct, Cyst                                      41 (85%)                                                                      
   Ovary                                              (49)                                                                          
      Atrophy                                         41 (84%)                                                                      
      Cyst                                            16 (33%)                                                                      
   Oviduct                                            (46)                                                                          
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
   Uterus                                             (49)                                                                          
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                        9 (18%)                                                                      
      Metaplasia, Squamous                            24 (49%)                                                                      
      Cervix, Cyst                                     1 (2%)                                                                       
      Cervix, Hyperplasia, Stromal                     2 (4%)                                                                       
      Endometrium, Hyperplasia, Cystic                23 (47%)                                                                      
   Vagina                                             (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)                                                                          
      Hyperplasia                                     40 (80%)                                                                      
   Lymph Node                                         (1)                                                                           
      Mediastinal, Hemorrhage                          1 (100%)                                                                     
   Lymph Node, Mandibular                             (48)                                                                          
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                        37 (77%)                                                                      
      Inflammation                                     1 (2%)                                                                       
   Spleen                                             (50)                                                                          
      Accessory Spleen                                 1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                44 (88%)                                                                      
      Hemorrhage                                       1 (2%)                                                                       
      Pigmentation                                    50 (100%)                                                                     
      Lymphoid Follicle, Atrophy                       4 (8%)                                                                       
   Thymus                                             (49)                                                                          
      Atrophy                                         29 (59%)                                                                      
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
      Necrosis, Lymphoid                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                                                          
      Cyst                                             3 (6%)                                                                       
      Cyst, Multiple                                   1 (2%)                                                                       
      Hyperplasia                                     27 (54%)                                                                      
      Inflammation, Granulomatous                      2 (4%)                                                                       
   Skin                                               (50)                                                                          
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                3000 UG/                                                                         
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               37 (74%)                                                                      
      Inflammation                                     9 (18%)                                                                      
      Alveolar Epithelium, Hyperplasia                 4 (8%)                                                                       
   Nose                                               (50)                                                                          
      Inflammation                                     2 (4%)                                                                       
      Septum, Inflammation                             4 (8%)                                                                       
      Turbinate, Inflammation                          5 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)                                                                          
      Retina, Atrophy                                  2 (4%)                                                                       
   Harderian Gland                                    (50)                                                                          
      Inflammation                                    15 (30%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)                                                                          
      Casts Protein                                    4 (8%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                                                                       
      Inflammation, Suppurative                        2 (4%)                                                                       
      Mineralization                                  38 (76%)                                                                      
      Nephropathy                                     22 (44%)                                                                      
      Pelvis, Inflammation                             3 (6%)                                                                       
      Transitional Epithelium, Hyperplasia             4 (8%)                                                                       
   Urinary Bladder                                    (49)                                                                          
      Inflammation                                    10 (20%)                                                                      
      Transitional Epithelium, Hyperplasia             3 (6%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------