National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17735

TDMS Study 89029-01 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: I. I. T. Research Inst                               MAGNETIC FIELDS (EMF)                                DATE: 10/25/04       
EXPERIMENT: 89029 TEST: 01                                                                                     TIME: 11:32:02       
TEST TYPE:  SUBCHRON 8-WEEK                                                                                    PAGE:       1        
CONT: N01-ES-25351                              ROUTE: MAGNETIC FIELDS                                         NTP C#: C89029       
PATHOLOGIST: BRENNECKE, L.                                                                                     CAS: ELECTROMAG      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: I. I. T. Research Inst                               MAGNETIC FIELDS (EMF)                                DATE: 10/25/04       
EXPERIMENT: 89029 TEST: 01                                                                                     TIME: 11:32:02       
TEST TYPE:  SUBCHRON 8-WEEK                                                                                                         
CONT: N01-ES-25351                              ROUTE: MAGNETIC FIELDS                                         NTP C#: C89029       
PATHOLOGIST: BRENNECKE, L.                                                                                     CAS: ELECTROMAG      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  MAGNETIC FIELDS (EMF)                                                                           
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Lung                                   Hemorrhage                                                                                   
Pancreas: Acinus                       Atrophy                                                                                      
===============================================================                                                                     
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 89029 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   MAGNETIC FIELDS (EMF)               
                                         Terminal Sacrifice at 9 weeks                                                              
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Infiltration Cellular Lymphocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   0/10 (0%)    0/10 (0%)    3/20 (15%)  |1/10 (10%)   1/10 (10%)   0/10 (0%)    1/20 (5%)    | 
|POLY-3 RATE (b)    |     1/10.00      0/10.00      0/10.00      3/20.00     |1/10.00      1/10.00      0/9.57       1/20.00      | 
|POLY-3 PERCENT (g) |     10.0%        0.0%         0.0%         15.0%       |10.0%        10.0%        0.0%         5.0%         | 
|TERMINAL (d)       |     1/10 (10%)   0/10 (0%)    0/10 (0%)    3/20 (15%)  |1/10 (10%)   1/10 (10%)   0/9 (0%)     1/20 (5%)    | 
|FIRST INCIDENCE    |     58 (T)       ---          ---          58 (T)      |59 (T)       59 (T)       ---          59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175      P=0.500N     P=0.500N     P=0.574     |P=0.533N     P=0.766      P=0.521N     P=0.600N     | 
|POLY 3             |     P=0.175      P=0.500N     P=0.500N     P=0.573     |P=0.532N     P=0.760      P=0.509N     P=0.599N     | 
|POLY 1.5           |     P=0.175      P=0.500N     P=0.500N     P=0.573     |P=0.535N     P=0.760      P=0.505N     P=0.599N     | 
|POLY 6             |     P=0.175      P=0.500N     P=0.500N     P=0.573     |P=0.527N     P=0.760      P=0.514N     P=0.599N     | 
|LOGISTIC REGRESSION|     P=0.175      (e)          (e)          P=0.574     |P=0.533N     P=0.766      (e)          P=0.600N     | 
|COCH-ARM / FISHERS |     P=0.172      P=0.500N     P=0.500N     P=0.593     |P=0.541N     P=0.763N     P=0.500N     P=0.563N     | 
|ORDER RESTRICTED   |     P=0.218      (e)          (e)          (e)         |P=0.389N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/10 (70%)   4/10 (40%)   5/10 (50%)   13/20 (65%) |1/10 (10%)   0/10 (0%)    0/10 (0%)    2/20 (10%)   | 
|POLY-3 RATE (b)    |     7/10.00      4/10.00      5/10.00      13/20.00    |1/10.00      0/10.00      0/9.57       2/20.00      | 
|POLY-3 PERCENT (g) |     70.0%        40.0%        50.0%        65.0%       |10.0%        0.0%         0.0%         10.0%        | 
|TERMINAL (d)       |     7/10 (70%)   4/10 (40%)   5/10 (50%)   13/20 (65%) |1/10 (10%)   0/10 (0%)    0/9 (0%)     2/20 (10%)   | 
|FIRST INCIDENCE    |     58 (T)       58 (T)       58 (T)       58 (T)      |59 (T)       ---          ---          59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.304      P=0.190N     P=0.328N     P=0.554N    |P=0.369      P=0.500N     P=0.521N     P=0.737      | 
|POLY 3             |     P=0.305      P=0.186N     P=0.329N     P=0.553N    |P=0.366      P=0.500N     P=0.509N     P=0.734      | 
|POLY 1.5           |     P=0.305      P=0.186N     P=0.329N     P=0.553N    |P=0.364      P=0.500N     P=0.505N     P=0.734      | 
|POLY 6             |     P=0.305      P=0.186N     P=0.329N     P=0.553N    |P=0.367      P=0.500N     P=0.514N     P=0.734      | 
|LOGISTIC REGRESSION|     P=0.304      P=0.190N     P=0.328N     P=0.554N    |P=0.369      (e)          (e)          P=0.737      | 
|COCH-ARM / FISHERS |     P=0.302      P=0.185N     P=0.325N     P=0.560N    |P=0.360      P=0.500N     P=0.500N     P=0.719N     | 
|ORDER RESTRICTED   |     P=0.356N     (e)          (e)          (e)         |P=0.386      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 89029 TEST: 01                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   MAGNETIC FIELDS (EMF)                
                                         Terminal Sacrifice at 9 weeks                                                              
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/20 (0%)   |0/10 (0%)    0/10 (0%)    0/10 (0%)    2/20 (10%)   | 
|POLY-3 RATE (b)    |     0/10.00      0/10.00      0/10.00      0/20.00     |0/10.00      0/10.00      0/9.57       2/20.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         10.0%        | 
|TERMINAL (d)       |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/20 (0%)   |0/10 (0%)    0/10 (0%)    0/9 (0%)     2/20 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.138      (e)          (e)          P=0.400      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.134      (e)          (e)          P=0.400      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.133      (e)          (e)          P=0.400      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.134      (e)          (e)          P=0.400      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.400      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.131      (e)          (e)          P=0.437      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.151      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    1/10 (10%)   3/20 (15%)  |3/10 (30%)   0/10 (0%)    1/10 (10%)   0/20 (0%)    | 
|POLY-3 RATE (b)    |     0/10.00      0/10.00      1/10.00      3/20.00     |3/10.00      0/10.00      1/9.57       0/20.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         10.0%        15.0%       |30.0%        0.0%         10.5%        0.0%         | 
|TERMINAL (d)       |     0/10 (0%)    0/10 (0%)    1/10 (10%)   3/20 (15%)  |3/10 (30%)   0/10 (0%)    1/9 (11%)    0/20 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          58 (T)       58 (T)      |59 (T)       ---          59 (T)       ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      (e)          P=0.500      P=0.263     |P=0.095N     P=0.111N     P=0.333N     P=0.028N*    | 
|POLY 3             |     P=0.123      (e)          P=0.500      P=0.261     |P=0.080N     P=0.095N     P=0.308N     P=0.017N*    | 
|POLY 1.5           |     P=0.123      (e)          P=0.500      P=0.261     |P=0.081N     P=0.095N     P=0.301N     P=0.017N*    | 
|POLY 6             |     P=0.123      (e)          P=0.500      P=0.261     |P=0.078N     P=0.095N     P=0.318N     P=0.017N*    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      P=0.263     |P=0.095N     (e)          P=0.333N     (e)          | 
|COCH-ARM / FISHERS |     P=0.121      (e)          P=0.500      P=0.281     |P=0.095N     P=0.105N     P=0.291N     P=0.030N*    | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |P=0.002N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 89029 TEST: 01                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   MAGNETIC FIELDS (EMF)                
                                         Terminal Sacrifice at 9 weeks                                                              
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/10 (0%)    1/10 (10%)   2/10 (20%)   2/20 (10%)   | 
|POLY-3 RATE (b)    |                                                        |0/10.00      1/10.00      2/9.57       2/20.00      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         10.0%        20.9%        10.0%        | 
|TERMINAL (d)       |                                                        |0/10 (0%)    1/10 (10%)   2/9 (22%)    2/20 (10%)   | 
|FIRST INCIDENCE    |                                                        |---          59 (T)       59 (T)       59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.589      P=0.500      P=0.210      P=0.400      | 
|POLY 3             |                                                        |P=0.577      P=0.500      P=0.216      P=0.400      | 
|POLY 1.5           |                                                        |P=0.578      P=0.500      P=0.220      P=0.400      | 
|POLY 6             |                                                        |P=0.576      P=0.500      P=0.210      P=0.400      | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.500      P=0.210      P=0.400      | 
|COCH-ARM / FISHERS |                                                        |P=0.581      P=0.500      P=0.237      P=0.437      | 
|ORDER RESTRICTED   |                                                        |P=0.204      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/20 (0%)   |2/10 (20%)   0/10 (0%)    0/10 (0%)    1/20 (5%)    | 
|POLY-3 RATE (b)    |     0/10.00      0/10.00      0/10.00      0/20.00     |2/10.00      0/10.00      0/9.57       1/20.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |20.0%        0.0%         0.0%         5.0%         | 
|TERMINAL (d)       |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/20 (0%)   |2/10 (20%)   0/10 (0%)    0/9 (0%)     1/20 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |59 (T)       ---          ---          59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.532N     P=0.234N     P=0.257N     P=0.263N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.532N     P=0.227N     P=0.237N     P=0.261N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.536N     P=0.227N     P=0.232N     P=0.261N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.527N     P=0.227N     P=0.243N     P=0.261N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.532N     (e)          (e)          P=0.263N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.540N     P=0.237N     P=0.237N     P=0.251N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.044N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 89029 TEST: 01                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   MAGNETIC FIELDS (EMF)                
                                         Terminal Sacrifice at 9 weeks                                                              
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    1/20 (5%)   |1/10 (10%)   0/10 (0%)    2/10 (20%)   2/20 (10%)   | 
|POLY-3 RATE (b)    |     0/10.00      0/10.00      0/10.00      1/20.00     |1/10.00      0/10.00      2/9.57       2/20.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.0%        |10.0%        0.0%         20.9%        10.0%        | 
|TERMINAL (d)       |     0/10 (0%)    0/10 (0%)    0/10 (0%)    1/20 (5%)   |1/10 (10%)   0/10 (0%)    2/9 (22%)    2/20 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          58 (T)      |59 (T)       ---          59 (T)       59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.365      (e)          (e)          P=0.638     |P=0.590      P=0.500N     P=0.461      P=0.737      | 
|POLY 3             |     P=0.367      (e)          (e)          P=0.637     |P=0.578      P=0.500N     P=0.484      P=0.734      | 
|POLY 1.5           |     P=0.367      (e)          (e)          P=0.637     |P=0.579      P=0.500N     P=0.491      P=0.734      | 
|POLY 6             |     P=0.367      (e)          (e)          P=0.637     |P=0.577      P=0.500N     P=0.475      P=0.734      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.638     |P=0.590      (e)          P=0.461      P=0.737      | 
|COCH-ARM / FISHERS |     P=0.364      (e)          (e)          P=0.667     |P=0.582      P=0.500N     P=0.500      P=0.719N     | 
|ORDER RESTRICTED   |     P=0.296      (e)          (e)          (e)         |P=0.380      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   1/10 (10%)   2/10 (20%)   5/20 (25%)  |2/10 (20%)   2/10 (20%)   1/10 (10%)   2/20 (10%)   | 
|POLY-3 RATE (b)    |     1/10.00      1/10.00      2/10.00      5/20.00     |2/10.00      2/10.00      1/10.00      2/20.00      | 
|POLY-3 PERCENT (g) |     10.0%        10.0%        20.0%        25.0%       |20.0%        20.0%        10.0%        10.0%        | 
|TERMINAL (d)       |     1/10 (10%)   1/10 (10%)   2/10 (20%)   5/20 (25%)  |2/10 (20%)   2/10 (20%)   0/9 (0%)     2/20 (10%)   | 
|FIRST INCIDENCE    |     58 (T)       58 (T)       58 (T)       58 (T)      |59 (T)       59 (T)       49           59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.207      P=0.766      P=0.500      P=0.317     |P=0.333N     P=0.707      P=0.525N     P=0.426N     | 
|POLY 3             |     P=0.210      P=0.760      P=0.500      P=0.317     |P=0.341N     P=0.702      P=0.500N     P=0.427N     | 
|POLY 1.5           |     P=0.210      P=0.760      P=0.500      P=0.317     |P=0.341N     P=0.702      P=0.500N     P=0.427N     | 
|POLY 6             |     P=0.210      P=0.760      P=0.500      P=0.317     |P=0.341N     P=0.702      P=0.500N     P=0.427N     | 
|LOGISTIC REGRESSION|     P=0.207      P=0.766      P=0.500      P=0.317     |P=0.333N     P=0.707      (e)          P=0.426N     | 
|COCH-ARM / FISHERS |     P=0.204      P=0.763N     P=0.500      P=0.326     |P=0.337N     P=0.709N     P=0.500N     P=0.407N     | 
|ORDER RESTRICTED   |     P=0.261      (e)          (e)          (e)         |P=0.377N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 89029 TEST: 01                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   MAGNETIC FIELDS (EMF)                
                                         Terminal Sacrifice at 9 weeks                                                              
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREAT.     .02          2            10          |UNTREAT.     .02          2            10           | 
|                   |     CONTROL      GAUSS        GAUSS        GAUSS       |CONTROL      GAUSS        GAUSS        GAUSS        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/10 (10%)   1/10 (10%)   2/10 (20%)   7/20 (35%)   | 
|POLY-3 RATE (b)    |                                                        |1/10.00      1/10.00      2/10.00      7/20.00      | 
|POLY-3 PERCENT (g) |                                                        |10.0%        10.0%        20.0%        35.0%        | 
|TERMINAL (d)       |                                                        |1/10 (10%)   1/10 (10%)   1/9 (11%)    7/20 (35%)   | 
|FIRST INCIDENCE    |                                                        |59 (T)       59 (T)       49           59 (T)       | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.067      P=0.766      P=0.475      P=0.158      | 
|POLY 3             |                                                        |P=0.056      P=0.760      P=0.500      P=0.153      | 
|POLY 1.5           |                                                        |P=0.056      P=0.760      P=0.500      P=0.153      | 
|POLY 6             |                                                        |P=0.056      P=0.760      P=0.500      P=0.153      | 
|LOGISTIC REGRESSION|                                                        |P=0.067      P=0.766      (e)          P=0.158      | 
|COCH-ARM / FISHERS |                                                        |P=0.056      P=0.763N     P=0.500      P=0.154      | 
|ORDER RESTRICTED   |                                                        |P=0.095      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.