National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17069

TDMS Study 96021-01 Pathology Tables


NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49

                                                            FINAL #3




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  35065-27-1

       Lock Date:  01/16/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           98           98           80           
  Early Deaths                                                                                                                      
    Natural Death                                     11           15            8            9           15           11           
    Moribund Sacrifice                                18           23           17           22           18           19           
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           16           28           20           20           21           
    Natural Death                                                                             1                                     
                                                                                                                                    
  Animals Examined Microscopically                    53           54           53           53           53           51           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (54)         (53)         (53)         (53)         (51)         
      Muscularis, Inflammation                                      3 [2.0]                   1 [2.0]      2 [2.0]      1 [2.0]     
      Periesophageal Tissue, Hemorrhage                                                       1 [3.0]                               
      Periesophageal Tissue, Inflammation                                                     1 [2.0]                               
   Intestine Large, Colon                             (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 [3.0]     
      Parasite Metazoan                                             1            1                         1            2           
   Intestine Large, Rectum                            (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 [3.0]     
      Parasite Metazoan                                1            2            3            7            5            5           
   Intestine Large, Cecum                             (53)         (54)         (53)         (53)         (53)         (50)         
      Inflammation, Chronic Active                                                                                      1 [3.0]     
   Intestine Small, Duodenum                          (53)         (54)         (53)         (53)         (53)         (51)         
      Parasite Metazoan                                                                                                 1           
   Intestine Small, Jejunum                           (53)         (54)         (53)         (53)         (53)         (50)         
      Peyer's Patch, Hyperplasia, Lymphoid             1 [2.0]                                                          1 [3.0]     
   Intestine Small, Ileum                             (52)         (54)         (53)         (53)         (53)         (50)         
      Hyperplasia, Lymphoid                            1 [3.0]                                                                      
   Liver                                              (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                      5 [1.8]      2 [2.5]      2 [1.0]      1 [1.0]      8 [1.9]      4 [1.5]     
      Basophilic Focus                                 8            5           16            6            3            8           
      Basophilic Focus, Multiple                       8           12            9            7            7            2           
      Cholangiofibrosis                                                                                    1 [2.0]                  
      Clear Cell Focus                                 3            3            4                                      2           
      Clear Cell Focus, Multiple                       3            2            1                                                  
      Eosinophilic Focus                               5            1            8            7           14            6           
      Eosinophilic Focus, Multiple                     7            1            8           12            9           12           
      Fatty Change, Diffuse                            3 [1.0]      7 [1.4]      2 [1.0]     11 [1.0]     21 [1.3]     17 [1.2]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change, Focal                              4 [1.0]                   3 [1.0]      5 [1.2]      4 [1.0]      1 [1.0]     
      Hematopoietic Cell Proliferation                20 [1.1]     22 [1.1]     13 [1.1]     18 [1.3]     16 [1.0]     14 [1.2]     
      Hepatodiaphragmatic Nodule                                                                           1            1           
      Hyperplasia, Nodular                                                                                 1                        
      Inflammation                                    44 [1.2]     39 [1.2]     44 [1.1]     47 [1.1]     48 [1.1]     45 [1.3]     
      Mixed Cell Focus                                 8            3            7            6            5            3           
      Mixed Cell Focus, Multiple                      21           16           22           19           19           12           
      Necrosis                                         7 [2.4]      7 [2.0]      7 [2.1]      5 [1.6]     12 [2.1]     10 [2.3]     
      Pigmentation                                     1 [1.0]      1 [1.0]      2 [1.5]      5 [1.6]      5 [1.2]      9 [1.0]     
      Bile Duct, Cyst                                  3 [2.7]      2 [2.0]      2 [2.5]      3 [2.0]      5 [2.6]      2 [2.5]     
      Bile Duct, Fibrosis                              2 [1.0]      1 [1.0]      2 [1.5]      2 [1.0]      2 [1.0]      3 [1.0]     
      Bile Duct, Hyperplasia                           5 [1.8]      3 [2.0]      2 [1.0]     14 [1.6]     10 [1.6]     17 [1.6]     
      Centrilobular, Degeneration                      2 [2.0]     10 [2.4]      4 [2.3]      2 [2.0]      2 [2.0]      5 [2.0]     
      Hepatocyte, Hypertrophy                                       5 [1.2]      5 [1.4]     24 [1.4]     39 [2.0]     41 [2.3]     
      Oval Cell, Hyperplasia                                                                  1 [1.0]                   4 [1.3]     
      Serosa, Fibrosis                                                                                                  1 [3.0]     
      Serosa, Inflammation                                                       2 [3.0]                                            
   Mesentery                                                                    (1)                       (1)                       
      Fat, Inflammation, Chronic Active                                          1 [3.0]                                            
   Oral Mucosa                                        (21)         (12)         (16)         (12)         (16)         (25)         
      Gingival, Hyperplasia, Squamous                 21 [1.0]     10 [1.7]     16 [1.1]     11 [1.1]     16 [1.4]     25 [1.1]     
   Pancreas                                           (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                                       1 [2.0]                                            
      Degeneration                                                  1 [2.0]                                                         
      Inflammation, Chronic Active                     2 [2.0]                   1 [1.0]      1 [2.0]                   2 [1.0]     
      Acinus, Atrophy                                  1 [1.0]                   1 [2.0]      1 [2.0]                   2 [1.5]     
      Acinus, Hyperplasia                              3 [2.7]                                                                      
      Acinus, Vacuolization Cytoplasmic                                                       1 [1.0]      1 [1.0]      2 [1.5]     
   Salivary Glands                                    (51)         (52)         (53)         (52)         (53)         (51)         
      Ectopic Tissue                                                                          1                                     
   Stomach, Forestomach                               (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperkeratosis                                                1 [2.0]                                1 [2.0]      2 [2.0]     
      Hyperplasia, Squamous                            3 [2.0]      4 [1.8]      2 [2.0]      6 [1.7]      4 [1.8]      4 [2.5]     
      Inflammation                                                                            3 [2.0]      3 [1.7]      2 [3.0]     
      Mineralization                                                1 [1.0]                   2 [1.5]      2 [2.0]                  
      Ulcer                                                                                   2 [3.0]      3 [2.0]      1 [2.0]     
      Serosa, Inflammation, Chronic Active                                       1 [3.0]                                            
   Stomach, Glandular                                 (53)         (54)         (53)         (53)         (53)         (51)         
      Erosion                                          1 [2.0]                   1 [2.0]      2 [2.0]                               
      Inflammation                                                                            2 [2.0]                               
      Mineralization                                   5 [1.8]      8 [1.3]      8 [1.3]     10 [1.5]     10 [1.5]      2 [1.5]     
   Tooth                                              (34)         (13)         (19)         (22)         (23)         (35)         
      Degeneration                                     1 [3.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Peridontal Tissue, Inflammation                 33 [1.2]     13 [1.4]     19 [1.1]     21 [1.2]     23 [1.4]     35 [1.3]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (52)         (54)         (53)         (53)         (53)         (51)         
      Aorta, Mineralization                            2 [2.0]      1 [2.0]                   1 [2.0]      1 [2.0]                  
   Heart                                              (52)         (54)         (53)         (53)         (53)         (51)         
      Cardiomyopathy                                  22 [1.1]     18 [1.2]     19 [1.0]     19 [1.2]     23 [1.1]     24 [1.1]     
      Inflammation                                                  2 [3.0]                   1 [2.0]                   1 [1.0]     
      Mineralization                                   1 [2.0]                                1 [1.0]                               
      Necrosis                                                      1 [3.0]                                                         
      Thrombosis                                                    2 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                     21 [1.9]     23 [1.7]     34 [1.8]     25 [1.6]     29 [1.6]     21 [1.9]     
      Atrophy                                                                                 1 [2.0]      2 [2.0]                  
      Degeneration, Cystic                             9 [2.1]     12 [2.2]     15 [2.3]     13 [2.2]     12 [2.0]     13 [1.8]     
      Hematopoietic Cell Proliferation                              1 [1.0]                   1 [1.0]                   3 [1.3]     
      Hyperplasia                                     18 [2.4]     24 [2.4]     27 [2.6]     27 [2.4]     28 [2.4]     11 [2.5]     
      Hypertrophy                                     48 [2.1]     35 [1.9]     45 [1.8]     35 [1.9]     42 [1.9]     41 [2.0]     
      Inflammation                                                                            1 [1.0]                   1 [1.0]     
      Mineralization                                                                          2 [2.0]      1 [2.0]                  
      Necrosis                                         1 [3.0]      2 [2.5]      1 [2.0]      2 [3.5]      3 [2.7]      3 [2.0]     
      Vacuolization Cytoplasmic                       10 [1.3]      8 [1.5]     14 [1.5]     16 [1.8]     12 [1.5]     14 [1.6]     
   Adrenal Medulla                                    (53)         (54)         (53)         (53)         (53)         (51)         
      Angiectasis                                                                1 [2.0]      1 [2.0]                               
      Hyperplasia                                     18 [2.1]     14 [2.1]     19 [1.9]     14 [2.3]     20 [2.1]     12 [1.9]     
   Islets, Pancreatic                                 (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperplasia                                      1 [2.0]                   1 [2.0]      1 [2.0]                               
   Parathyroid Gland                                  (49)         (46)         (50)         (47)         (46)         (48)         
      Angiectasis                                                                             1 [1.0]                               
      Cyst                                             1 [2.0]                                                                      
      Fibrosis                                                      1 [3.0]                                                         
      Hyperplasia                                      2 [1.5]                                1 [2.0]                   1 [2.0]     
   Pituitary Gland                                    (53)         (54)         (53)         (53)         (53)         (50)         
      Angiectasis                                     15 [2.0]     16 [2.5]     20 [2.5]     26 [2.2]     28 [2.4]     14 [2.3]     
      Atypia Cellular                                                                         1 [2.0]                               
      Cyst                                                                       1 [2.0]                                1 [2.0]     
      Cytoplasmic Alteration                           2 [1.5]                   1 [2.0]                   1 [2.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                                                                            1 [1.0]                  
      Pars Distalis, Hyperplasia                      23 [2.4]     18 [2.2]     22 [2.4]     16 [2.4]     23 [2.3]     25 [2.2]     
   Thyroid Gland                                      (51)         (52)         (53)         (53)         (53)         (51)         
      Angiectasis                                                   1 [2.0]                                1 [2.0]                  
      C-Cell, Hyperplasia                             19 [1.9]     17 [2.1]     23 [2.0]     17 [1.6]     19 [1.9]     16 [1.9]     
      Follicular Cell, Hyperplasia                     1 [2.0]                                             2 [2.0]      2 [1.5]     
      Follicular Cell, Hypertrophy                     5 [2.0]      9 [1.7]      9 [1.9]     12 [1.7]     10 [2.1]     17 [1.8]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (51)         (52)         (53)         (51)         (50)         
      Atrophy                                                                                 1 [2.0]                               
      Inflammation                                    52 [1.6]     45 [1.9]     41 [1.8]     48 [1.6]     48 [1.6]     46 [1.4]     
      Inflammation, Chronic Active                                                                                      1 [4.0]     
      Duct, Cyst                                      49 [2.3]     40 [2.5]     36 [2.4]     43 [2.4]     45 [2.3]     41 [2.3]     
   Ovary                                              (53)         (53)         (53)         (53)         (53)         (50)         
      Atrophy                                         47 [4.0]     43 [4.0]     42 [4.0]     38 [4.0]     44 [3.9]     39 [3.9]     
      Cyst                                            14 [2.2]      7 [2.3]     17 [2.2]     17 [2.2]     16 [2.3]     17 [2.2]     
      Inflammation, Chronic Active                                               2 [3.5]      1 [2.0]      5 [3.0]      7 [3.6]     
      Necrosis                                                                   1 [2.0]                                            
      Interstitial Cell, Hyperplasia                   1 [2.0]                                                          1 [3.0]     
   Oviduct                                            (50)         (38)         (44)         (35)         (39)         (45)         
      Cyst                                                          1 [2.0]      2 [3.0]      1 [2.0]      1 [3.0]                  
      Dilatation                                                                 1 [3.0]                                1 [4.0]     
      Inflammation, Chronic Active                     1 [3.0]                   2 [2.5]      1 [3.0]      5 [3.2]      7 [3.3]     
   Uterus                                             (53)         (54)         (53)         (53)         (53)         (50)         
      Adenomyosis                                      2 [3.5]      1 [2.0]                   1 [2.0]                   1 [3.0]     
      Angiectasis                                                   1 [3.0]                                1 [3.0]                  
      Congestion                                                                              1 [1.0]                               
      Cyst                                                                       1 [3.0]      1 [3.0]                               
      Hemorrhage                                                    2 [3.0]                                                         
      Inflammation, Chronic Active                     2 [3.0]      1 [3.0]      5 [2.4]      4 [2.8]      2 [3.0]      8 [3.0]     
      Inflammation, Suppurative                        5 [1.6]      6 [1.8]      6 [1.8]      2 [1.0]     16 [2.0]      8 [1.6]     
      Metaplasia, Squamous                            23 [2.3]     29 [2.1]     27 [2.5]     17 [2.3]     27 [2.7]     32 [2.6]     
      Thrombosis                                                                              1 [3.0]      2 [3.0]                  
      Ulcer                                                         1 [2.0]                                                         
      Cervix, Hyperplasia, Stromal                     1 [3.0]                                             2 [3.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cervix, Inflammation, Suppurative                1 [3.0]                                                                      
      Endometrium, Hyperplasia, Cystic                37 [2.4]     29 [2.1]     32 [2.4]     28 [2.3]     25 [2.2]     21 [2.1]     
      Endometrium, Hyperplasia, Stromal                                                                    1 [3.0]                  
   Vagina                                             (1)          (3)          (2)          (1)          (1)          (3)          
      Inflammation                                                               1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (54)         (53)         (53)         (53)         (51)         
      Hyperplasia                                     34 [2.9]     41 [3.3]     40 [3.0]     38 [3.1]     42 [3.2]     46 [2.9]     
   Lymph Node                                         (3)          (3)          (3)          (2)          (5)          (6)          
      Hemorrhage                                                                 1 [2.0]                                            
      Hyperplasia, Lymphoid                                                      1 [3.0]                                            
      Hyperplasia, Plasma Cell                                      1 [3.0]      1 [3.0]                                            
      Iliac, Ectasia                                                                                       1 [2.0]                  
      Iliac, Hyperplasia, Plasma Cell                                                                      1 [3.0]                  
      Lumbar, Ectasia                                               1 [3.0]      2 [3.0]                                2 [2.5]     
      Lumbar, Hemorrhage                                                         1 [2.0]                                1 [2.0]     
      Lumbar, Hyperplasia, Histiocytic                                                                     1 [2.0]                  
      Lumbar, Hyperplasia, Plasma Cell                                                                     1 [3.0]      2 [2.0]     
      Mediastinal, Congestion                          3 [2.0]                                                                      
      Mediastinal, Ectasia                                                                                              2 [2.0]     
      Mediastinal, Hyperplasia, Histiocytic            1 [2.0]                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 [2.0]      1 [2.0]                                                         
      Mediastinal, Hyperplasia, Plasma Cell            1 [3.0]      1 [2.0]                                                         
      Renal, Ectasia                                                                                                    2 [3.5]     
      Renal, Hyperplasia, Plasma Cell                                                                                   1 [2.0]     
      Renal, Inflammation, Chronic Active                                                     1 [4.0]                               
   Lymph Node, Mandibular                             (51)         (52)         (53)         (51)         (53)         (51)         
      Congestion                                                                                           1 [2.0]                  
      Ectasia                                                                    1 [2.0]                   1 [2.0]      1 [3.0]     
      Hemorrhage                                                                 1 [2.0]                                            
      Hyperplasia, Lymphoid                            1 [2.0]      1 [2.0]      2 [2.5]      1 [2.0]      3 [2.3]      1 [2.0]     
      Hyperplasia, Plasma Cell                        37 [2.3]     36 [2.2]     30 [2.3]     33 [2.4]     37 [2.4]     38 [2.3]     
      Inflammation                                                                                                      1 [3.0]     
   Lymph Node, Mesenteric                             (52)         (54)         (53)         (53)         (53)         (51)         
      Ectasia                                                       1 [1.0]                                                         
      Hemorrhage                                       1 [2.0]                                                                      
      Hyperplasia, Plasma Cell                                                                                          1 [3.0]     
      Inflammation, Chronic Active                                                                                      1 [4.0]     
   Spleen                                             (53)         (54)         (53)         (53)         (53)         (51)         
      Hematopoietic Cell Proliferation                46 [1.7]     48 [2.3]     52 [2.2]     48 [1.9]     46 [1.8]     47 [1.7]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                                                                                        1 [3.0]     
      Infarct                                                                                                           1 [3.0]     
      Necrosis                                                      1 [2.0]      1 [2.0]                                1 [3.0]     
      Pigmentation                                    47 [1.5]     42 [1.5]     47 [1.6]     49 [1.4]     49 [1.5]     46 [1.4]     
      Lymphoid Follicle, Atrophy                       1 [2.0]      6 [2.3]      2 [2.0]      3 [2.7]      3 [2.0]      3 [2.7]     
      Red Pulp, Atrophy                                                                       2 [2.5]                               
   Thymus                                             (48)         (53)         (52)         (53)         (53)         (47)         
      Atrophy                                         38 [2.6]     38 [2.7]     37 [2.7]     35 [2.6]     41 [2.7]     30 [2.6]     
      Cyst                                                          1 [3.0]                                             1 [2.0]     
      Hemorrhage                                                    3 [2.3]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                             2 [3.0]      1 [3.0]                   2 [2.5]      1 [2.0]      3 [2.7]     
      Hyperplasia                                     22 [1.5]     23 [1.4]     32 [1.2]     27 [1.4]     32 [1.3]     22 [1.4]     
      Inflammation, Chronic Active                                               1 [3.0]                                            
      Inflammation, Granulomatous                                   2 [2.0]      2 [2.0]      3 [1.7]                   1 [2.0]     
   Skin                                               (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                                                                              1 [2.0]     
      Cyst Epithelial Inclusion                                     1                                      1                        
      Inflammation                                                                                         1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (54)         (53)         (53)         (53)         (51)         
      Hemorrhage                                       1 [3.0]                   1 [2.0]      1 [2.0]      2 [3.0]                  
      Hydrocephalus                                                                           2 [2.0]      1 [1.0]                  
      Hyperplasia, Histiocytic                                                                1 [3.0]                               
      Mineralization                                                                          1 [2.0]                               
      Necrosis                                         1 [3.0]                                1 [2.0]                               
      Vacuolization Cytoplasmic                                                                                         1 [2.0]     
      Glial Cell, Hyperplasia                                       1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (52)         (54)         (53)         (53)         (53)         (51)         
      Congestion                                                                                           1 [2.0]                  
      Hemorrhage                                       1 [2.0]                                                          1 [1.0]     
      Infiltration Cellular, Histiocyte               45 [1.6]     40 [1.6]     40 [1.8]     40 [1.4]     27 [1.4]     28 [1.3]     
      Inflammation                                     6 [2.2]      7 [1.9]      2 [2.0]      6 [2.2]      7 [1.7]      9 [1.7]     
      Metaplasia, Squamous                                                                    1 [1.0]      1 [2.0]      1 [2.0]     
      Mineralization                                                                          1 [3.0]      1 [3.0]                  
      Alveolar Epithelium, Hyperplasia                20 [1.1]     21 [1.4]     16 [1.3]     11 [1.2]      9 [1.1]      6 [1.0]     
      Mediastinum, Hemorrhage                                                                 1 [3.0]                               
      Serosa, Inflammation, Chronic Active                                                    1 [3.0]                               
   Nose                                               (53)         (54)         (53)         (53)         (53)         (51)         
      Cyst                                                          1 [3.0]                                                         
      Inflammation                                     1 [1.0]      6 [2.0]      3 [2.0]      6 [1.5]      6 [1.8]      3 [2.0]     
      Goblet Cell, Hyperplasia                                                   2 [2.5]      1 [2.0]      2 [2.0]                  
      Nasolacrimal Duct, Inflammation                  2 [3.0]                                                          2 [2.5]     
      Respiratory Epithelium, Hyperplasia                                        2 [2.0]                   1 [2.0]                  
      Respiratory Epithelium, Mineralization                        1 [2.0]                                                         
      Septum, Inflammation                             4 [1.5]      3 [2.0]      5 [1.8]      3 [1.0]      7 [1.4]      6 [1.5]     
      Squamous Epithelium, Hyperplasia                              1 [2.0]                                                         
      Turbinate, Inflammation                          8 [1.1]      3 [1.7]      5 [1.4]      9 [1.4]     10 [1.7]     10 [1.5]     
   Trachea                                            (52)         (54)         (53)         (53)         (53)         (51)         
      Inflammation                                                                                                      1 [2.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (53)         (54)         (53)         (53)         (52)         (51)         
      Degeneration                                     1 [3.0]                                                                      
      Anterior Chamber, Exudate                                                                            1 [2.0]                  
      Lens, Degeneration                                                                      1 [1.0]                               
      Retina, Atrophy                                  2 [1.5]                   1 [1.0]                   1 [1.0]                  
   Harderian Gland                                    (53)         (54)         (53)         (53)         (53)         (49)         
      Atrophy                                                       1 [1.0]                                                         
      Inflammation                                    20 [1.0]      9 [1.1]     13 [1.1]     16 [1.1]     16 [1.1]     16 [1.2]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (54)         (53)         (53)         (53)         (51)         
      Accumulation, Hyaline Droplet                                 3 [2.0]      1 [3.0]                                1 [1.0]     
      Calculus Micro Observation Only                  3            5            4            7            5            1           
      Casts Protein                                    3 [1.0]      2 [1.5]      2 [1.0]      1 [2.0]                   1 [2.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 UG/KG      10 UG/KG     100          300          1000         3000         
                                                                                UG/KG        UG/KG        UG/KG        UG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cyst                                             1 [2.0]                                1 [2.0]                               
      Degeneration                                                               1 [2.0]                                            
      Hydronephrosis                                                             1 [3.0]                   1 [3.0]                  
      Infarct                                          1 [3.0]                   1 [3.0]      2 [2.5]                               
      Inflammation, Chronic Active                                  2 [1.0]                                3 [1.7]      1 [1.0]     
      Inflammation, Suppurative                        1 [1.0]      2 [2.0]      3 [1.0]      2 [1.0]      2 [1.0]      3 [2.0]     
      Mineralization                                  40 [1.1]     42 [1.1]     41 [1.0]     39 [1.1]     40 [1.1]     41 [1.0]     
      Necrosis                                                      1 [3.0]                                                         
      Nephropathy                                     34 [1.1]     23 [1.1]     24 [1.0]     33 [1.1]     28 [1.2]     34 [1.1]     
      Pelvis, Dilatation                                            2 [2.5]                                                         
      Pelvis, Inflammation                             1 [2.0]      4 [2.0]      2 [2.5]      4 [2.3]      5 [1.8]      4 [2.0]     
      Renal Tubule, Degeneration                                                 1 [3.0]                                1 [3.0]     
      Renal Tubule, Hyperplasia                                     1 [2.0]                                                         
      Transitional Epithelium, Hyperplasia             1 [2.0]      5 [1.8]      2 [2.5]      4 [2.0]      6 [1.8]      4 [2.3]     
   Ureter                                                                       (1)                                                 
      Cyst                                                                       1 [3.0]                                            
   Urinary Bladder                                    (53)         (53)         (53)         (53)         (53)         (50)         
      Calculus Micro Observation Only                               1                                                               
      Inflammation                                     8 [1.1]     11 [1.6]      6 [1.7]      8 [2.0]     13 [1.2]      9 [1.9]     
      Transitional Epithelium, Hyperplasia                          3 [2.3]      2 [2.5]      3 [2.0]      2 [2.0]      3 [2.3]     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   3000 UG/                                                                      
                                                      KG STOP                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50                                                                            
  Early Deaths                                                                                                                      
    Natural Death                                     14                                                                            
    Moribund Sacrifice                                16                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                20                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)                                                                          
      Muscularis, Inflammation                         3 [1.3]                                                                      
   Intestine Large, Rectum                            (50)                                                                          
      Parasite Metazoan                                3                                                                            
   Intestine Large, Cecum                             (48)                                                                          
      Inflammation                                     1 [3.0]                                                                      
      Ulcer                                            1 [3.0]                                                                      
   Liver                                              (50)                                                                          
      Angiectasis                                      8 [1.6]                                                                      
      Basophilic Focus                                 8                                                                            
      Basophilic Focus, Multiple                       2                                                                            
      Clear Cell Focus                                 1                                                                            
      Degeneration, Cystic                             1 [2.0]                                                                      
      Eosinophilic Focus                               4                                                                            
      Eosinophilic Focus, Multiple                    10                                                                            
      Fatty Change, Diffuse                           15 [1.1]                                                                      
      Fatty Change, Focal                              6 [1.2]                                                                      
      Hematopoietic Cell Proliferation                17 [1.2]                                                                      
      Hepatodiaphragmatic Nodule                       2                                                                            
      Hyperplasia, Histiocytic                         1 [2.0]                                                                      
      Hyperplasia, Nodular                             1                                                                            
      Inflammation                                    44 [1.1]                                                                      
      Mixed Cell Focus                                 7                                                                            
      Mixed Cell Focus, Multiple                      13                                                                            
      Necrosis                                         9 [2.7]                                                                      
      Pigmentation                                     3 [1.3]                                                                      
      Bile Duct, Cyst                                  3 [2.0]                                                                      
      Bile Duct, Fibrosis                              5 [1.2]                                                                      
      Bile Duct, Hyperplasia                          12 [1.7]                                                                      
      Centrilobular, Degeneration                      5 [2.2]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   3000 UG/                                                                      
                                                      KG STOP                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hypertrophy                         32 [1.8]                                                                      
      Oval Cell, Hyperplasia                           2 [1.0]                                                                      
   Oral Mucosa                                        (15)                                                                          
      Gingival, Hyperplasia, Squamous                 15 [1.1]                                                                      
   Pancreas                                           (50)                                                                          
      Inflammation, Chronic Active                     2 [1.0]                                                                      
      Acinus, Atrophy                                  3 [2.0]                                                                      
      Acinus, Hyperplasia                              2 [2.0]                                                                      
      Acinus, Vacuolization Cytoplasmic                1 [2.0]                                                                      
   Salivary Glands                                    (48)                                                                          
      Inflammation, Chronic Active                     1 [2.0]                                                                      
   Stomach, Forestomach                               (50)                                                                          
      Hyperkeratosis                                   2 [2.0]                                                                      
      Hyperplasia, Squamous                            5 [2.0]                                                                      
      Inflammation                                     4 [1.5]                                                                      
      Mineralization                                   3 [1.7]                                                                      
   Stomach, Glandular                                 (50)                                                                          
      Inflammation                                     1 [3.0]                                                                      
      Mineralization                                   3 [1.3]                                                                      
      Ulcer                                            1 [3.0]                                                                      
      Serosa, Inflammation                             1 [2.0]                                                                      
   Tooth                                              (27)                                                                          
      Peridontal Tissue, Inflammation                 27 [1.4]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                                                                          
      Cardiomyopathy                                  15 [1.1]                                                                      
      Epicardium, Inflammation                         1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)                                                                          
      Angiectasis                                     20 [1.7]                                                                      
      Degeneration, Cystic                             7 [1.7]                                                                      
      Hematopoietic Cell Proliferation                 2 [1.5]                                                                      
      Hyperplasia                                     18 [2.3]                                                                      
      Hypertrophy                                     35 [1.8]                                                                      
      Necrosis                                         1 [2.0]                                                                      
      Vacuolization Cytoplasmic                       12 [1.1]                                                                      
   Adrenal Medulla                                    (50)                                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   3000 UG/                                                                      
                                                      KG STOP                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Angiectasis                                      1 [2.0]                                                                      
      Hyperplasia                                     19 [2.2]                                                                      
   Parathyroid Gland                                  (45)                                                                          
      Hyperplasia                                      1 [2.0]                                                                      
   Pituitary Gland                                    (50)                                                                          
      Angiectasis                                     24 [2.3]                                                                      
      Pars Distalis, Hyperplasia                      18 [2.4]                                                                      
      Rathke's Cleft, Pars Nervosa, Cyst               1 [2.0]                                                                      
   Thyroid Gland                                      (49)                                                                          
      C-Cell, Hyperplasia                             13 [1.9]                                                                      
      Follicular Cell, Hypertrophy                    12 [1.8]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)                                                                          
      Inflammation                                    44 [1.5]                                                                      
      Duct, Cyst                                      41 [2.3]                                                                      
   Ovary                                              (49)                                                                          
      Atrophy                                         41 [3.9]                                                                      
      Cyst                                            16 [2.4]                                                                      
   Oviduct                                            (46)                                                                          
      Dilatation                                       1 [3.0]                                                                      
      Inflammation, Chronic Active                     2 [3.0]                                                                      
   Uterus                                             (49)                                                                          
      Cyst                                             1 [4.0]                                                                      
      Inflammation, Chronic Active                     1 [3.0]                                                                      
      Inflammation, Suppurative                        9 [2.2]                                                                      
      Metaplasia, Squamous                            24 [2.7]                                                                      
      Cervix, Cyst                                     1 [3.0]                                                                      
      Cervix, Hyperplasia, Stromal                     2 [3.0]                                                                      
      Endometrium, Hyperplasia, Cystic                23 [1.8]                                                                      
   Vagina                                             (1)                                                                           
      Inflammation, Chronic Active                     1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   3000 UG/                                                                      
                                                      KG STOP                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)                                                                          
      Hyperplasia                                     40 [3.1]                                                                      
   Lymph Node                                         (1)                                                                           
      Mediastinal, Hemorrhage                          1 [2.0]                                                                      
   Lymph Node, Mandibular                             (48)                                                                          
      Ectasia                                          1 [2.0]                                                                      
      Hyperplasia, Lymphoid                            1 [3.0]                                                                      
      Hyperplasia, Plasma Cell                        37 [2.5]                                                                      
      Inflammation                                     1 [3.0]                                                                      
   Spleen                                             (50)                                                                          
      Accessory Spleen                                 1                                                                            
      Congestion                                       1 [3.0]                                                                      
      Hematopoietic Cell Proliferation                44 [1.9]                                                                      
      Hemorrhage                                       1 [2.0]                                                                      
      Pigmentation                                    50 [1.3]                                                                      
      Lymphoid Follicle, Atrophy                       4 [2.3]                                                                      
   Thymus                                             (49)                                                                          
      Atrophy                                         29 [2.4]                                                                      
      Hemorrhage                                       1 [3.0]                                                                      
      Inflammation                                     1 [3.0]                                                                      
      Necrosis, Lymphoid                               1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                                                          
      Cyst                                             3 [2.3]                                                                      
      Cyst, Multiple                                   1 [3.0]                                                                      
      Hyperplasia                                     27 [1.5]                                                                      
      Inflammation, Granulomatous                      2 [1.5]                                                                      
   Skin                                               (50)                                                                          
      Ulcer                                            1 [4.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/09/03    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                     Time: 10:00:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   3000 UG/                                                                      
                                                      KG STOP                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                                                          
      Hemorrhage                                       1 [2.0]                                                                      
      Infiltration Cellular, Histiocyte               37 [1.3]                                                                      
      Inflammation                                     9 [1.8]                                                                      
      Alveolar Epithelium, Hyperplasia                 4 [1.3]                                                                      
   Nose                                               (50)                                                                          
      Inflammation                                     2 [1.5]                                                                      
      Septum, Inflammation                             4 [1.3]                                                                      
      Turbinate, Inflammation                          5 [1.2]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)                                                                          
      Retina, Atrophy                                  2 [2.0]                                                                      
   Harderian Gland                                    (50)                                                                          
      Inflammation                                    15 [1.2]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)                                                                          
      Casts Protein                                    4 [1.0]                                                                      
      Cyst                                             1 [2.0]                                                                      
      Fibrosis                                         1 [1.0]                                                                      
      Inflammation, Chronic Active                     3 [2.7]                                                                      
      Inflammation, Suppurative                        2 [2.0]                                                                      
      Mineralization                                  38 [1.0]                                                                      
      Nephropathy                                     22 [1.2]                                                                      
      Pelvis, Inflammation                             3 [1.3]                                                                      
      Transitional Epithelium, Hyperplasia             4 [1.5]                                                                      
   Urinary Bladder                                    (49)                                                                          
      Inflammation                                    10 [1.7]                                                                      
      Transitional Epithelium, Hyperplasia             3 [2.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.