Share This:
https://ntp.niehs.nih.gov/go/16110

TDMS Study 88138-02 Pathology Tables

NTP Experiment-Test: 88138-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04
Route: DOSED FEED                                                                                                 Time: 13:30:43




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  08/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88138-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:30:43    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           0.125%       0.25%        0.5%         1.0%         2.0%            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                  3           
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            6           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                     8 (80%)      9 (90%)      9 (90%)      9 (90%)      9 (90%)      3 (30%)     
      Centrilobular, Hypertrophy                       3 (30%)      9 (90%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Hepatocyte, Vacuolization Cytoplasmic                                                   2 (20%)      9 (90%)      1 (10%)     
   Salivary Glands                                    (10)                                                             (10)         
      Infiltration Cellular, Mononuclear Cell          1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Myocardium, Mineralization                                                                                        2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)                                   (1)                       (10)         
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:30:43    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0%           0.125%       0.25%        0.5%         1.0%         2.0%            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                             (10)         
      Lymphoid Follicle, Depletion Cellular                                                                             1 (10%)     
   Thymus                                             (10)                                                             (7)          
      Atrophy                                                                                                           5 (71%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)                                                             (10)         
      Cyst Epithelial Inclusion                        1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                (1)          (10)         
      Arteriole, Vasculitis, Acute                                                                         1 (100%)                 
   Nose                                               (10)                                                             (10)         
      Inflammation, Chronic Active                                                                                      5 (50%)     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:30:43    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0%           0.125%       0.25%        0.5%         1.0%         2.0%            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Accidently Killed                                               1                                                               
    Moribund Sacrifice                                                                                                  6           
    Natural Death                                                                                                       4           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10           10           10                        
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                     5 (50%)      4 (40%)      8 (80%)      8 (80%)      5 (50%)      1 (10%)     
      Centrilobular, Hypertrophy                       3 (30%)      8 (80%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Hepatocyte, Vacuolization Cytoplasmic                                                                             3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (1)                                    (10)         (10)         
      Myocardium, Mineralization                                                                                        2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:30:43    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0%           0.125%       0.25%        0.5%         1.0%         2.0%            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (10)         (1)                                    (10)         (10)         
      Lymphoid Follicle, Depletion Cellular                                                                             5 (50%)     
   Thymus                                             (8)          (1)                                    (10)         (8)          
      Atrophy                                                                                                           7 (88%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (1)                                    (10)         (10)         
      Alveolus, Hemorrhage, Acute                                   1 (100%)                                                        
      Arteriole, Embolus                                            1 (100%)                                                        
   Nose                                               (10)         (1)                                    (10)         (10)         
      Inflammation, Chronic Active                                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (1)                                    (10)         (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Renal Tubule, Regeneration                                                                           1 (10%)                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------