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TDMS Study 88139-05 Pathology Tables

NTP Experiment-Test: 88139-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97
Route: GAVAGE                                                                                                     Time: 14:29:54

                                                       13 WEEK SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  56-93-9

       Lock Date:  05/18/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88139-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Dosing Accident                                                              1                                                  
    Natural Death                                                                                          2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10            9            9            8                        
    Accidently Killed                                                                         1                                     
  Animals Examined Microscopically                    10            3            2           10           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (1)          (1)                       (10)                      
      Inflammation, Focal                              5 (50%)                                             4 (40%)                  
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                                            1 (100%)                                           
   Mesentery                                          (1)                       (1)                                                 
      Fat, Necrosis                                    1 (100%)                  1 (100%)                                           
   Pancreas                                           (10)                      (1)                       (10)                      
      Acinus, Atrophy                                                                                      1 (10%)                  
      Acinus, Degeneration, Focal                      1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                      (1)                       (10)                      
      Inflammation, Focal                              5 (50%)                   1 (100%)                  4 (40%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)                                                (10)                      
      Pars Distalis, Cyst                                                                                  1 (10%)                  
   Thyroid Gland                                      (10)                      (1)                       (10)                      
      Follicle, Cyst                                   1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 88139-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (10)         (2)          (1)          (1)          (10)                      
      Bilateral, Cyst                                               2 (100%)                  1 (100%)                              
      Bilateral, Dilatation                            2 (20%)                                             2 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                      (1)                       (10)                      
      Hematopoietic Cell Proliferation                 1 (10%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                      (1)          (10)         (10)                      
      Congestion                                                                                           1 (10%)                  
      Inflammation, Focal                              3 (30%)                   1 (100%)     3 (30%)      6 (60%)                  
   Nose                                               (10)                                                (10)                      
      Inflammation, Chronic Active                     1 (10%)                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 88139-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10                        
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10                        
  Animals Examined Microscopically                    10            2            1           10           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (2)                                    (10)                      
      Inflammation, Focal                              4 (40%)                                             5 (50%)                  
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                                                                      1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (10)                      
      Inflammation, Focal                              8 (80%)                                             5 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)                                                (10)                      
      Cyst                                             1 (10%)                                             1 (10%)                  
   Thyroid Gland                                      (10)                                                (10)                      
      Follicle, Cyst                                   2 (20%)                                             1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)                      (1)                       (10)                      
      Inflammation, Focal, Granulomatous                                         1 (100%)                                           
   Prostate                                           (10)                                                (10)                      
      Infiltration Cellular, Focal, Lymphocyte         1 (10%)                                                                      
      Inflammation                                                                                         1 (10%)                  
   Testes                                             (10)                      (1)                       (10)                      
      Atrophy                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 88139-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                (10)                      
      Hematopoietic Cell Proliferation                 3 (30%)                                             4 (40%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                   (10)         (10)                      
      Inflammation, Focal                              6 (60%)                                1 (10%)      5 (50%)                  
   Nose                                               (10)                                                (10)                      
      Inflammation                                     2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                      (1)                       (10)                      
      Renal Tubule, Hemorrhage, Focal                  1 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
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