National Toxicology Program

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TDMS Study 05201-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 11/15/04       
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 14:18:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 98-00-0         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 11/15/04       
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 14:18:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 98-00-0         
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 11/15/04       
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 14:18:35       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 98-00-0         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                    FURFURYL ALCOHOL                                                                              
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Islets, Pancreatic                     Carcinoma or Adenoma                                                                         
Nose                                   Squamous Cell Carcinoma                                                                      
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Skin                                   Keratoacanthoma                                                                              
Skin: Sebaceous Gland                  Carcinoma                                                                                    
Testes                                 Adenoma                                                                                      
Thyroid Gland: C-Cell                  Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Zymbal's Gland                         Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Clitoral/Preputial Gland               Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Kidney: Renal Tubule                   Adenoma                                                                                      
Mammary Gland                          Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Uterus                                 Polyp Stromal                                                                                
                                       Sarcoma Stromal                                                                              
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                     FURFURYL ALCOHOL      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/48 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/32.38      1/32.19      1/33.46      0/27.31     |2/40.56      0/41.69      0/38.93      2/37.77      | 
|POLY-3 PERCENT (g) |     0.0%         3.1%         3.0%         0.0%        |4.9%         0.0%         0.0%         5.3%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     ---          606          693          ---         |609          ---          ---          518          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.717N     P=0.513      P=0.513      (e)         |P=0.264      P=0.237N     P=0.258N     P=0.598      | 
|POLY 3             |     P=0.564N     P=0.499      P=0.507      (e)         |P=0.323      P=0.231N     P=0.246N     P=0.669      | 
|POLY 1.5           |     P=0.540N     P=0.501      P=0.505      (e)         |P=0.333      P=0.232N     P=0.243N     P=0.682      | 
|POLY 6             |     P=0.615N     P=0.492      P=0.507      (e)         |P=0.310      P=0.229N     P=0.252N     P=0.649      | 
|LOGISTIC REGRESSION|     P=0.570N     P=0.499      P=0.506      (e)         |P=0.363      P=0.238N     P=0.246N     P=0.691N     | 
|COCH-ARM / FISHERS |     P=0.522N     P=0.500      P=0.500      (e)         |P=0.348      P=0.247N     P=0.258N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.414      (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  27/50 (54%)  22/50 (44%)  26/50 (52%) |4/50 (8%)    7/50 (14%)   4/48 (8%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     19/36.35     27/39.73     22/39.32     26/37.28    |4/40.45      7/41.87      4/39.31      7/37.69      | 
|POLY-3 PERCENT (g) |     52.3%        68.0%        56.0%        69.7%       |9.9%         16.7%        10.2%        18.6%        | 
|TERMINAL (d)       |     5/8 (63%)    4/5 (80%)    4/9 (44%)    0/0 (0%)    |1/26 (4%)    5/26 (19%)   1/22 (5%)    3/16 (19%)   | 
|FIRST INCIDENCE    |     532          490          492          555         |707          693          679          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.044 *    P=0.439      P<0.001 **  |P=0.103      P=0.275      P=0.555      P=0.110      | 
|POLY 3             |     P=0.150      P=0.097      P=0.462      P=0.069     |P=0.260      P=0.278      P=0.629      P=0.217      | 
|POLY 1.5           |     P=0.196      P=0.093      P=0.414      P=0.093     |P=0.286      P=0.275      P=0.631      P=0.239      | 
|POLY 6             |     P=0.092      P=0.095      P=0.541      P=0.037 *   |P=0.226      P=0.282      P=0.619      P=0.189      | 
|LOGISTIC REGRESSION|     P=0.070      P=0.058      P=0.376      P=0.013 *   |P=0.183      P=0.294      P=0.616      P=0.174      | 
|COCH-ARM / FISHERS |     P=0.242      P=0.080      P=0.342      P=0.114     |P=0.320      P=0.262      P=0.619      P=0.262      | 
|ORDER RESTRICTED   |     P=0.066      (e)          (e)          (e)         |P=0.211      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/48 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/32.38      0/31.75      2/34.08      1/27.66     |1/40.12      0/41.69      0/38.93      0/37.12      | 
|POLY-3 PERCENT (g) |     3.1%         0.0%         5.9%         3.6%        |2.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     735 (T)      ---          554          638         |735 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.307      P=0.594N     P=0.497      P=0.362     |P=0.629N     P=0.500N     P=0.533N     P=0.597N     | 
|POLY 3             |     P=0.531      P=0.504N     P=0.518      P=0.726     |P=0.553N     P=0.492N     P=0.506N     P=0.516N     | 
|POLY 1.5           |     P=0.567      P=0.500N     P=0.512      P=0.747     |P=0.552N     P=0.494N     P=0.505N     P=0.508N     | 
|POLY 6             |     P=0.444      P=0.514N     P=0.525      P=0.671     |P=0.554N     P=0.490N     P=0.510N     P=0.527N     | 
|LOGISTIC REGRESSION|     P=0.532      (e)          P=0.508      P=0.544     |P=0.629N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.594      P=0.500N     P=0.500      P=0.753N    |P=0.546N     P=0.500N     P=0.510N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.382      (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  27/50 (54%)  24/50 (48%)  26/50 (52%) |5/50 (10%)   8/50 (16%)   4/48 (8%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     19/36.35     27/39.73     24/40.11     26/37.28    |5/40.45      8/42.40      4/39.31      7/37.69      | 
|POLY-3 PERCENT (g) |     52.3%        68.0%        59.8%        69.7%       |12.4%        18.9%        10.2%        18.6%        | 
|TERMINAL (d)       |     5/8 (63%)    4/5 (80%)    4/9 (44%)    0/0 (0%)    |2/26 (8%)    5/26 (19%)   1/22 (5%)    3/16 (19%)   | 
|FIRST INCIDENCE    |     532          490          492          555         |707          571          679          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.044 *    P=0.314      P<0.001 **  |P=0.178      P=0.289      P=0.594N     P=0.170      | 
|POLY 3             |     P=0.162      P=0.097      P=0.319      P=0.069     |P=0.378      P=0.304      P=0.518N     P=0.327      | 
|POLY 1.5           |     P=0.211      P=0.093      P=0.271      P=0.093     |P=0.410      P=0.297      P=0.514N     P=0.353      | 
|POLY 6             |     P=0.099      P=0.095      P=0.411      P=0.037 *   |P=0.336      P=0.314      P=0.531N     P=0.292      | 
|LOGISTIC REGRESSION|     P=0.080      P=0.058      P=0.232      P=0.013 *   |P=0.312      P=0.305      P=0.536N     P=0.264      | 
|COCH-ARM / FISHERS |     P=0.260      P=0.080      P=0.210      P=0.114     |P=0.450      P=0.277      P=0.526N     P=0.380      | 
|ORDER RESTRICTED   |     P=0.065      (e)          (e)          (e)         |P=0.355      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/32.38      1/32.35      0/33.30      0/27.31     |0/40.12      0/41.69      2/40.40      1/37.12      | 
|POLY-3 PERCENT (g) |     0.0%         3.1%         0.0%         0.0%        |0.0%         0.0%         5.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     ---          543          ---          ---         |---          ---          628          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.609N     P=0.510      (e)          (e)         |P=0.357      (e)          P=0.240      P=0.403      | 
|POLY 3             |     P=0.618N     P=0.500      (e)          (e)         |P=0.378      (e)          P=0.238      P=0.484      | 
|POLY 1.5           |     P=0.613N     P=0.502      (e)          (e)         |P=0.397      (e)          P=0.238      P=0.492      | 
|POLY 6             |     P=0.620N     P=0.493      (e)          (e)         |P=0.350      (e)          P=0.236      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.598N     P=0.471      (e)          (e)         |P=0.421      (e)          P=0.210      P=0.403      | 
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.420      (e)          P=0.242      P=0.500      | 
|ORDER RESTRICTED   |     P=0.410N     (e)          (e)          (e)         |P=0.169      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/32.84      1/32.35      0/33.30      0/27.31     |0/40.12      0/41.69      2/40.40      1/37.12      | 
|POLY-3 PERCENT (g) |     3.0%         3.1%         0.0%         0.0%        |0.0%         0.0%         5.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     595          543          ---          ---         |---          ---          628          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.356N     P=0.751N     P=0.512N     P=0.512N    |P=0.357      (e)          P=0.240      P=0.403      | 
|POLY 3             |     P=0.366N     P=0.759      P=0.497N     P=0.537N    |P=0.378      (e)          P=0.238      P=0.484      | 
|POLY 1.5           |     P=0.358N     P=0.761N     P=0.497N     P=0.515N    |P=0.397      (e)          P=0.238      P=0.492      | 
|POLY 6             |     P=0.373N     P=0.750      P=0.501N     P=0.586N    |P=0.350      (e)          P=0.236      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.337N     P=0.750      P=0.510N     P=0.495N    |P=0.421      (e)          P=0.210      P=0.403      | 
|COCH-ARM / FISHERS |     P=0.348N     P=0.753N     P=0.500N     P=0.500N    |P=0.420      (e)          P=0.242      P=0.500      | 
|ORDER RESTRICTED   |     P=0.285N     (e)          (e)          (e)         |P=0.169      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    3/50 (6%)    2/49 (4%)    2/50 (4%)   |4/44 (9%)    2/45 (4%)    2/46 (4%)    7/45 (16%)   | 
|POLY-3 RATE (b)    |     2/32.60      3/32.65      2/32.48      2/27.95     |4/35.28      2/37.93      2/37.51      7/34.78      | 
|POLY-3 PERCENT (g) |     6.1%         9.2%         6.2%         7.2%        |11.3%        5.3%         5.3%         20.1%        | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |3/24 (13%)   1/23 (4%)    1/21 (5%)    2/14 (14%)   | 
|FIRST INCIDENCE    |     572          616          730          609         |693          679          627          518          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.346      P=0.465      P=0.663N     P=0.539     |P=0.016 *    P=0.342N     P=0.385N     P=0.124      | 
|POLY 3             |     P=0.608N     P=0.501      P=0.695      P=0.640     |P=0.044 *    P=0.302N     P=0.307N     P=0.246      | 
|POLY 1.5           |     P=0.565N     P=0.509      P=0.692N     P=0.677     |P=0.050      P=0.309N     P=0.305N     P=0.261      | 
|POLY 6             |     P=0.536      P=0.480      P=0.685      P=0.546     |P=0.038 *    P=0.295N     P=0.317N     P=0.226      | 
|LOGISTIC REGRESSION|     P=0.623      P=0.510      P=0.688N     P=0.689     |P=0.044 *    P=0.296N     P=0.321N     P=0.238      | 
|COCH-ARM / FISHERS |     P=0.531N     P=0.510      P=0.691N     P=0.684N    |P=0.059      P=0.328N     P=0.317N     P=0.274      | 
|ORDER RESTRICTED   |     P=0.647      (e)          (e)          (e)         |P=0.056      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/50 (4%)    5/49 (10%)   3/50 (6%)   |3/44 (7%)    0/45 (0%)    2/46 (4%)    2/45 (4%)    | 
|POLY-3 RATE (b)    |     3/32.45      2/32.77      5/34.01      3/29.07     |3/35.22      0/37.71      2/37.77      2/33.09      | 
|POLY-3 PERCENT (g) |     9.3%         6.1%         14.7%        10.3%       |8.5%         0.0%         5.3%         6.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     2/9 (22%)    0/0 (0%)    |2/24 (8%)    0/23 (0%)    1/21 (5%)    2/14 (14%)   | 
|FIRST INCIDENCE    |     572          399          554          522         |707          ---          522          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.248      P=0.547N     P=0.386      P=0.309     |P=0.391      P=0.124N     P=0.547N     P=0.651      | 
|POLY 3             |     P=0.495      P=0.495N     P=0.379      P=0.614     |P=0.514      P=0.105N     P=0.468N     P=0.529N     | 
|POLY 1.5           |     P=0.545      P=0.487N     P=0.374      P=0.651     |P=0.538      P=0.108N     P=0.467N     P=0.508N     | 
|POLY 6             |     P=0.377      P=0.521N     P=0.381      P=0.515     |P=0.481      P=0.103N     P=0.478N     P=0.561N     | 
|LOGISTIC REGRESSION|     P=0.596      P=0.492N     P=0.366      P=0.650N    |P=0.519      P=0.104N     P=0.474N     P=0.641N     | 
|COCH-ARM / FISHERS |     P=0.583      P=0.490N     P=0.357      P=0.651N    |P=0.570      P=0.117N     P=0.479N     P=0.489N     | 
|ORDER RESTRICTED   |     P=0.412      (e)          (e)          (e)         |P=0.291N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    5/50 (10%)   7/49 (14%)   5/50 (10%)  |7/44 (16%)   2/45 (4%)    4/46 (9%)    9/45 (20%)   | 
|POLY-3 RATE (b)    |     4/32.88      5/33.67      7/34.03      5/29.71     |7/35.39      2/37.93      4/38.15      9/34.78      | 
|POLY-3 PERCENT (g) |     12.2%        14.9%        20.6%        16.8%       |19.8%        5.3%         10.5%        25.9%        | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     3/9 (33%)    0/0 (0%)    |5/24 (21%)   1/23 (4%)    2/21 (10%)   4/14 (29%)   | 
|FIRST INCIDENCE    |     572          399          554          522         |693          679          522          518          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.094      P=0.441      P=0.309      P=0.132     |P=0.014 *    P=0.085N     P=0.325N     P=0.147      | 
|POLY 3             |     P=0.445      P=0.515      P=0.272      P=0.434     |P=0.052      P=0.059N     P=0.214N     P=0.372      | 
|POLY 1.5           |     P=0.509      P=0.522      P=0.273      P=0.483     |P=0.060      P=0.063N     P=0.216N     P=0.394      | 
|POLY 6             |     P=0.304      P=0.492      P=0.263      P=0.317     |P=0.042 *    P=0.056N     P=0.221N     P=0.340      | 
|LOGISTIC REGRESSION|     P=0.511      P=0.513      P=0.272      P=0.499     |P=0.051      P=0.058N     P=0.230N     P=0.322      | 
|COCH-ARM / FISHERS |     P=0.556      P=0.513      P=0.262      P=0.513     |P=0.076      P=0.073N     P=0.236N     P=0.411      | 
|ORDER RESTRICTED   |     P=0.379      (e)          (e)          (e)         |P=0.072      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    0/49 (0%)   |1/49 (2%)    0/48 (0%)    3/48 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/32.93      0/31.75      2/33.30      0/27.04     |1/39.18      0/40.44      3/39.12      0/37.12      | 
|POLY-3 PERCENT (g) |     9.1%         0.0%         6.0%         0.0%        |2.6%         0.0%         7.7%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     2/9 (22%)    0/0 (0%)    |1/26 (4%)    0/26 (0%)    3/22 (14%)   0/16 (0%)    | 
|FIRST INCIDENCE    |     624          ---          735 (T)      ---         |735 (T)      ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617N     P=0.175N     P=0.458N     P=0.537N    |P=0.555N     P=0.500N     P=0.245      P=0.597N     | 
|POLY 3             |     P=0.229N     P=0.122N     P=0.495N     P=0.154N    |P=0.442N     P=0.494N     P=0.304      P=0.511N     | 
|POLY 1.5           |     P=0.210N     P=0.119N     P=0.492N     P=0.134N    |P=0.421N     P=0.497N     P=0.305      P=0.503N     | 
|POLY 6             |     P=0.275N     P=0.133N     P=0.505N     P=0.216N    |P=0.473N     P=0.489N     P=0.297      P=0.522N     | 
|LOGISTIC REGRESSION|     P=0.448N     P=0.133N     P=0.485N     P=0.276N    |P=0.555N     (e)          P=0.245      (e)          | 
|COCH-ARM / FISHERS |     P=0.196N     P=0.121N     P=0.500N     P=0.125N    |P=0.397N     P=0.505N     P=0.301      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.057N     (e)          (e)          (e)         |P=0.281N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    0/49 (0%)   |1/49 (2%)    1/48 (2%)    4/48 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/32.93      1/31.75      3/33.55      0/27.04     |1/39.18      1/40.45      4/39.12      0/37.12      | 
|POLY-3 PERCENT (g) |     12.2%        3.2%         8.9%         0.0%        |2.6%         2.5%         10.2%        0.0%         | 
|TERMINAL (d)       |     2/8 (25%)    1/5 (20%)    2/9 (22%)    0/0 (0%)    |1/26 (4%)    0/26 (0%)    4/22 (18%)   0/16 (0%)    | 
|FIRST INCIDENCE    |     624          735 (T)      666          ---         |735 (T)      732          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.526N     P=0.293N     P=0.451N     P=0.537N    |P=0.449N     P=0.756N     P=0.128      P=0.597N     | 
|POLY 3             |     P=0.128N     P=0.185N     P=0.489N     P=0.085N    |P=0.325N     P=0.754N     P=0.176      P=0.511N     | 
|POLY 1.5           |     P=0.111N     P=0.179N     P=0.489N     P=0.071N    |P=0.304N     P=0.757N     P=0.178      P=0.503N     | 
|POLY 6             |     P=0.177N     P=0.203N     P=0.496N     P=0.135N    |P=0.358N     P=0.749N     P=0.170      P=0.522N     | 
|LOGISTIC REGRESSION|     P=0.346N     P=0.220N     P=0.482N     P=0.271N    |P=0.430N     P=0.748N     P=0.128      (e)          | 
|COCH-ARM / FISHERS |     P=0.100N     P=0.181N     P=0.500N     P=0.061N    |P=0.281N     P=0.747      P=0.175      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.042N*    (e)          (e)          (e)         |P=0.198N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/32.58      1/31.79      2/33.54      0/27.31     |0/40.12      0/41.22      0/39.69      2/37.42      | 
|POLY-3 PERCENT (g) |     3.1%         3.2%         6.0%         0.0%        |0.0%         0.0%         0.0%         5.4%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     681          726          700          ---         |---          ---          ---          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.852      P=0.708      P=0.536      P=0.872N    |P=0.026 *    (e)          (e)          P=0.190      | 
|POLY 3             |     P=0.373N     P=0.757      P=0.510      P=0.535N    |P=0.037 *    (e)          (e)          P=0.221      | 
|POLY 1.5           |     P=0.341N     P=0.761      P=0.509      P=0.514N    |P=0.039 *    (e)          (e)          P=0.229      | 
|POLY 6             |     P=0.448N     P=0.746      P=0.510      P=0.584N    |P=0.035 *    (e)          (e)          P=0.211      | 
|LOGISTIC REGRESSION|     P=0.634N     P=0.732      P=0.510      P=0.697N    |P=0.035 *    (e)          (e)          P=0.217      | 
|COCH-ARM / FISHERS |     P=0.317N     P=0.753N     P=0.500      P=0.500N    |P=0.043 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.305N     (e)          (e)          (e)         |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/32.58      1/31.79      2/33.54      0/27.31     |0/40.12      1/41.44      0/39.69      2/37.42      | 
|POLY-3 PERCENT (g) |     3.1%         3.2%         6.0%         0.0%        |0.0%         2.4%         0.0%         5.4%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     681          726          700          ---         |---          677          ---          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.852      P=0.708      P=0.536      P=0.872N    |P=0.109      P=0.523      (e)          P=0.190      | 
|POLY 3             |     P=0.373N     P=0.757      P=0.510      P=0.535N    |P=0.142      P=0.506      (e)          P=0.221      | 
|POLY 1.5           |     P=0.341N     P=0.761      P=0.509      P=0.514N    |P=0.148      P=0.503      (e)          P=0.229      | 
|POLY 6             |     P=0.448N     P=0.746      P=0.510      P=0.584N    |P=0.134      P=0.511      (e)          P=0.211      | 
|LOGISTIC REGRESSION|     P=0.634N     P=0.732      P=0.510      P=0.697N    |P=0.139      P=0.496      (e)          P=0.217      | 
|COCH-ARM / FISHERS |     P=0.317N     P=0.753N     P=0.500      P=0.500N    |P=0.155      P=0.495      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.305N     (e)          (e)          (e)         |P=0.064      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/32.38      2/32.37      1/33.46      0/27.31     |1/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     0.0%         6.2%         3.0%         0.0%        |2.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          604          693          ---         |735 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.645N     P=0.234      P=0.513      (e)         |P=0.629N     P=0.500N     P=0.533N     P=0.597N     | 
|POLY 3             |     P=0.412N     P=0.235      P=0.507      (e)         |P=0.553N     P=0.492N     P=0.502N     P=0.516N     | 
|POLY 1.5           |     P=0.385N     P=0.238      P=0.505      (e)         |P=0.552N     P=0.494N     P=0.501N     P=0.508N     | 
|POLY 6             |     P=0.472N     P=0.228      P=0.507      (e)         |P=0.554N     P=0.490N     P=0.507N     P=0.527N     | 
|LOGISTIC REGRESSION|     P=0.441N     P=0.234      P=0.506      (e)         |P=0.629N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.247      P=0.500      (e)         |P=0.546N     P=0.500N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.342      (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/32.38      2/32.37      2/33.67      0/27.31     |1/40.12      0/41.69      1/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     0.0%         6.2%         5.9%         0.0%        |2.5%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    0/26 (0%)    1/22 (5%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          604          679          ---         |735 (T)      ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.706N     P=0.234      P=0.230      (e)         |P=0.587N     P=0.500N     P=0.725      P=0.597N     | 
|POLY 3             |     P=0.408N     P=0.235      P=0.244      (e)         |P=0.502N     P=0.492N     P=0.759      P=0.516N     | 
|POLY 1.5           |     P=0.371N     P=0.238      P=0.243      (e)         |P=0.492N     P=0.494N     P=0.760      P=0.508N     | 
|POLY 6             |     P=0.497N     P=0.228      P=0.246      (e)         |P=0.515N     P=0.490N     P=0.754      P=0.527N     | 
|LOGISTIC REGRESSION|     P=0.445N     P=0.234      P=0.242      (e)         |P=0.587N     (e)          P=0.725      (e)          | 
|COCH-ARM / FISHERS |     P=0.346N     P=0.247      P=0.247      (e)         |P=0.477N     P=0.500N     P=0.747      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.286      (e)          (e)          (e)         |P=0.267N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |9/50 (18%)   2/50 (4%)    2/49 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/32.56      0/31.75      2/33.87      0/27.31     |9/40.73      2/42.59      2/39.90      6/38.11      | 
|POLY-3 PERCENT (g) |     3.1%         0.0%         5.9%         0.0%        |22.1%        4.7%         5.0%         15.7%        | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |5/26 (19%)   0/26 (0%)    1/22 (5%)    2/16 (13%)   | 
|FIRST INCIDENCE    |     686          ---          554          ---         |661          497          679          518          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.752N     P=0.500N     P=0.520      P=0.974N    |P=0.272      P=0.029N*    P=0.051N     P=0.564N     | 
|POLY 3             |     P=0.490N     P=0.505N     P=0.514      P=0.535N    |P=0.433      P=0.019N*    P=0.025N*    P=0.332N     | 
|POLY 1.5           |     P=0.460N     P=0.500N     P=0.511      P=0.514N    |P=0.459      P=0.021N*    P=0.025N*    P=0.308N     | 
|POLY 6             |     P=0.560N     P=0.517N     P=0.516      P=0.583N    |P=0.398      P=0.017N*    P=0.028N*    P=0.371N     | 
|LOGISTIC REGRESSION|     P=0.510N     P=0.518N     P=0.508      P=0.728N    |P=0.443      P=0.024N*    P=0.030N*    P=0.369N     | 
|COCH-ARM / FISHERS |     P=0.437N     P=0.500N     P=0.500      P=0.500N    |P=0.498      P=0.026N*    P=0.028N*    P=0.288N     | 
|ORDER RESTRICTED   |     P=0.359N     (e)          (e)          (e)         |P=0.038N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |10/50 (20%)  2/50 (4%)    2/49 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/32.56      0/31.75      2/33.87      0/27.31     |10/40.73     2/42.59      2/39.90      6/38.11      | 
|POLY-3 PERCENT (g) |     3.1%         0.0%         5.9%         0.0%        |24.6%        4.7%         5.0%         15.7%        | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |6/26 (23%)   0/26 (0%)    1/22 (5%)    2/16 (13%)   | 
|FIRST INCIDENCE    |     686          ---          554          ---         |661          497          679          518          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.752N     P=0.500N     P=0.520      P=0.974N    |P=0.331      P=0.017N*    P=0.032N*    P=0.481N     | 
|POLY 3             |     P=0.490N     P=0.505N     P=0.514      P=0.535N    |P=0.510      P=0.010N*    P=0.013N*    P=0.243N     | 
|POLY 1.5           |     P=0.460N     P=0.500N     P=0.511      P=0.514N    |P=0.537      P=0.011N*    P=0.013N*    P=0.222N     | 
|POLY 6             |     P=0.560N     P=0.517N     P=0.516      P=0.583N    |P=0.475      P=0.008N**   P=0.015N*    P=0.276N     | 
|LOGISTIC REGRESSION|     P=0.510N     P=0.518N     P=0.508      P=0.728N    |P=0.514      P=0.013N*    P=0.017N*    P=0.282N     | 
|COCH-ARM / FISHERS |     P=0.437N     P=0.500N     P=0.500      P=0.500N    |P=0.575      P=0.014N*    P=0.015N*    P=0.207N     | 
|ORDER RESTRICTED   |     P=0.359N     (e)          (e)          (e)         |P=0.017N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    5/50 (10%)   0/50 (0%)   |19/50 (38%)  24/50 (48%)  25/49 (51%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     2/32.69      1/32.27      5/33.77      0/27.31     |19/41.79     24/43.86     25/43.47     20/39.66     | 
|POLY-3 PERCENT (g) |     6.1%         3.1%         14.8%        0.0%        |45.5%        54.7%        57.5%        50.4%        | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     4/9 (44%)    0/0 (0%)    |11/26 (42%)  17/26 (65%)  13/22 (59%)  10/16 (63%)  | 
|FIRST INCIDENCE    |     648          578          592          ---         |627          497          546          497          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.632N     P=0.580N     P=0.234      P=0.690N    |P=0.120      P=0.253      P=0.089      P=0.097      | 
|POLY 3             |     P=0.273N     P=0.505N     P=0.223      P=0.278N    |P=0.556N     P=0.254      P=0.176      P=0.407      | 
|POLY 1.5           |     P=0.227N     P=0.499N     P=0.224      P=0.253N    |P=0.478N     P=0.245      P=0.168      P=0.458      | 
|POLY 6             |     P=0.402N     P=0.521N     P=0.217      P=0.343N    |P=0.459      P=0.258      P=0.176      P=0.331      | 
|LOGISTIC REGRESSION|     P=0.410N     P=0.507N     P=0.221      P=0.498N    |P=0.511      P=0.256      P=0.137      P=0.326      | 
|COCH-ARM / FISHERS |     P=0.198N     P=0.500N     P=0.218      P=0.247N    |P=0.390N     P=0.210      P=0.135      P=0.500      | 
|ORDER RESTRICTED   |     P=0.159N     (e)          (e)          (e)         |P=0.328      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    5/50 (10%)   0/50 (0%)   |20/50 (40%)  24/50 (48%)  25/49 (51%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     2/32.69      1/32.27      5/33.77      0/27.31     |20/41.79     24/43.86     25/43.47     20/39.66     | 
|POLY-3 PERCENT (g) |     6.1%         3.1%         14.8%        0.0%        |47.9%        54.7%        57.5%        50.4%        | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     4/9 (44%)    0/0 (0%)    |12/26 (46%)  17/26 (65%)  13/22 (59%)  10/16 (63%)  | 
|FIRST INCIDENCE    |     648          578          592          ---         |627          497          546          497          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.632N     P=0.580N     P=0.234      P=0.690N    |P=0.138      P=0.317      P=0.118      P=0.125      | 
|POLY 3             |     P=0.273N     P=0.505N     P=0.223      P=0.278N    |P=0.506N     P=0.333      P=0.242      P=0.496      | 
|POLY 1.5           |     P=0.227N     P=0.499N     P=0.224      P=0.253N    |P=0.430N     P=0.319      P=0.229      P=0.544      | 
|POLY 6             |     P=0.402N     P=0.521N     P=0.217      P=0.343N    |P=0.511      P=0.340      P=0.245      P=0.418      | 
|LOGISTIC REGRESSION|     P=0.410N     P=0.507N     P=0.221      P=0.498N    |P=0.555      P=0.331      P=0.187      P=0.401      | 
|COCH-ARM / FISHERS |     P=0.198N     P=0.500N     P=0.218      P=0.247N    |P=0.346N     P=0.273      P=0.184      P=0.581N     | 
|ORDER RESTRICTED   |     P=0.159N     (e)          (e)          (e)         |P=0.435      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    6/50 (12%)   0/50 (0%)   |25/50 (50%)  25/50 (50%)  26/49 (53%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     3/32.88      1/32.27      6/34.35      0/27.31     |25/42.23     25/44.07     26/43.68     23/40.49     | 
|POLY-3 PERCENT (g) |     9.1%         3.1%         17.5%        0.0%        |59.2%        56.7%        59.5%        56.8%        | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     4/9 (44%)    0/0 (0%)    |15/26 (58%)  17/26 (65%)  13/22 (59%)  11/16 (69%)  | 
|FIRST INCIDENCE    |     648          578          554          ---         |627          497          546          497          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.513N     P=0.371N     P=0.269      P=0.630N    |P=0.115      P=0.530N     P=0.302      P=0.172      | 
|POLY 3             |     P=0.203N     P=0.309N     P=0.257      P=0.152N    |P=0.498N     P=0.494N     P=0.578      P=0.500N     | 
|POLY 1.5           |     P=0.161N     P=0.304N     P=0.255      P=0.131N    |P=0.427N     P=0.514N     P=0.549      P=0.451N     | 
|POLY 6             |     P=0.330N     P=0.326N     P=0.253      P=0.215N    |P=0.527      P=0.486N     P=0.591      P=0.587N     | 
|LOGISTIC REGRESSION|     P=0.252N     P=0.316N     P=0.250      P=0.317N    |P=0.542      P=0.494N     P=0.480      P=0.564      | 
|COCH-ARM / FISHERS |     P=0.137N     P=0.309N     P=0.243      P=0.121N    |P=0.350N     P=0.579N     P=0.459      P=0.421N     | 
|ORDER RESTRICTED   |     P=0.118N     (e)          (e)          (e)         |P=0.636N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/48 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/32.38      0/31.75      0/33.30      3/28.52     |0/39.18      0/41.69      0/39.24      0/36.77      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         10.5%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          606         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   (e)          (e)          P=0.081     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.006 **   (e)          (e)          P=0.094     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.007 **   (e)          (e)          P=0.108     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.004 **   (e)          (e)          P=0.068     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.008 **   (e)          (e)          P=0.107     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.008 **   (e)          (e)          P=0.121     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.004 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Papilloma Squamous or Papilloma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/32.38      0/31.75      0/33.30      1/27.76     |1/40.85      2/41.69      0/39.69      1/37.22      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         3.6%        |2.5%         4.8%         0.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    2/26 (8%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          601         |478          735 (T)      ---          711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.220      (e)          (e)          P=0.500     |P=0.690N     P=0.505      P=0.487N     P=0.740      | 
|POLY 3             |     P=0.206      (e)          (e)          P=0.469     |P=0.612N     P=0.507      P=0.506N     P=0.740      | 
|POLY 1.5           |     P=0.218      (e)          (e)          P=0.488     |P=0.604N     P=0.506      P=0.503N     P=0.750      | 
|POLY 6             |     P=0.179      (e)          (e)          P=0.426     |P=0.623N     P=0.509      P=0.512N     P=0.726      | 
|LOGISTIC REGRESSION|     P=0.234      (e)          (e)          P=0.502     |P=0.589N     P=0.483      P=0.643N     P=0.761N     | 
|COCH-ARM / FISHERS |     P=0.228      (e)          (e)          P=0.500     |P=0.593N     P=0.500      P=0.505N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.097      (e)          (e)          (e)         |P=0.409N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    3/50 (6%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/32.38      0/31.75      0/33.30      1/27.76     |1/40.85      3/42.43      0/39.69      2/37.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         3.6%        |2.5%         7.1%         0.0%         5.3%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    2/26 (8%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          601         |478          469          ---          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.220      (e)          (e)          P=0.500     |P=0.480      P=0.313      P=0.487N     P=0.472      | 
|POLY 3             |     P=0.206      (e)          (e)          P=0.469     |P=0.535      P=0.318      P=0.506N     P=0.471      | 
|POLY 1.5           |     P=0.218      (e)          (e)          P=0.488     |P=0.549      P=0.315      P=0.503N     P=0.485      | 
|POLY 6             |     P=0.179      (e)          (e)          P=0.426     |P=0.518      P=0.323      P=0.512N     P=0.452      | 
|LOGISTIC REGRESSION|     P=0.234      (e)          (e)          P=0.502     |P=0.594      P=0.246      P=0.643N     P=0.507      | 
|COCH-ARM / FISHERS |     P=0.228      (e)          (e)          P=0.500     |P=0.565      P=0.309      P=0.505N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.097      (e)          (e)          (e)         |P=0.402      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  37/50 (74%)  39/48 (81%)  31/50 (62%) |38/50 (76%)  35/49 (71%)  34/48 (71%)  35/50 (70%)  | 
|POLY-3 RATE (b)    |     36/43.50     37/44.98     39/43.40     31/41.03    |38/46.09     35/46.25     34/44.51     35/43.99     | 
|POLY-3 PERCENT (g) |     82.8%        82.3%        89.9%        75.6%       |82.4%        75.7%        76.4%        79.6%        | 
|TERMINAL (d)       |     7/8 (88%)    4/5 (80%)    9/9 (100%)   0/0 (0%)    |21/26 (81%)  20/26 (77%)  17/22 (77%)  12/16 (75%)  | 
|FIRST INCIDENCE    |     333          399          478          472         |477          469          546          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.274      P=0.476      P=0.005 **  |P=0.055      P=0.328N     P=0.556N     P=0.158      | 
|POLY 3             |     P=0.146N     P=0.598N     P=0.220      P=0.260N    |P=0.545      P=0.285N     P=0.315N     P=0.466N     | 
|POLY 1.5           |     P=0.097N     P=0.608N     P=0.221      P=0.206N    |P=0.498N     P=0.297N     P=0.300N     P=0.381N     | 
|POLY 6             |     P=0.324N     P=0.627N     P=0.215      P=0.442N    |P=0.448      P=0.293N     P=0.372N     P=0.576N     | 
|LOGISTIC REGRESSION|     P=0.128N     P=0.519      P=0.249      P=0.263N    |P=0.527N     P=0.309N     P=0.296N     P=0.431N     | 
|COCH-ARM / FISHERS |     P=0.077N     P=0.500      P=0.200      P=0.198N    |P=0.370N     P=0.387N     P=0.363N     P=0.326N     | 
|ORDER RESTRICTED   |     P=0.141N     (e)          (e)          (e)         |P=0.411N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/32.38      1/31.87      3/33.79      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     0.0%         3.1%         8.9%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          705          666          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.610      P=0.481      P=0.136      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.513N     P=0.497      P=0.124      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.468N     P=0.500      P=0.123      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.623N     P=0.488      P=0.125      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.723N     P=0.469      P=0.123      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.437N     P=0.500      P=0.121      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.232      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/32.55      0/31.75      1/33.30      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     6.1%         0.0%         3.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     690          ---          735 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.874N     P=0.316N     P=0.465N     P=0.970N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.329N     P=0.241N     P=0.492N     P=0.276N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.314N     P=0.237N     P=0.492N     P=0.252N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.358N     P=0.252N     P=0.495N     P=0.341N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.727N     P=0.275N     P=0.479N     P=0.762N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.300N     P=0.247N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.100N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/32.55      1/31.87      4/33.79      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     6.1%         3.1%         11.8%        0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     690          705          666          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.692      P=0.588N     P=0.378      P=0.970N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.267N     P=0.507N     P=0.351      P=0.276N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.229N     P=0.500N     P=0.349      P=0.252N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.372N     P=0.526N     P=0.353      P=0.341N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.585N     P=0.562N     P=0.348      P=0.762N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.203N     P=0.500N     P=0.339      P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.188N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   4/50 (8%)    11/50 (22%)  4/50 (8%)   |1/50 (2%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     7/33.30      4/32.23      11/35.77     4/28.88     |1/40.12      2/41.69      0/39.69      1/37.12      | 
|POLY-3 PERCENT (g) |     21.0%        12.4%        30.8%        13.9%       |2.5%         4.8%         0.0%         2.7%         | 
|TERMINAL (d)       |     2/8 (25%)    1/5 (20%)    2/9 (22%)    0/0 (0%)    |1/26 (4%)    2/26 (8%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     591          644          492          555         |735 (T)      735 (T)      ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051      P=0.436N     P=0.294      P=0.109     |P=0.653      P=0.500      P=0.533N     P=0.650      | 
|POLY 3             |     P=0.379N     P=0.270N     P=0.253      P=0.340N    |P=0.610N     P=0.513      P=0.502N     P=0.744      | 
|POLY 1.5           |     P=0.313N     P=0.260N     P=0.241      P=0.290N    |P=0.603N     P=0.510      P=0.501N     P=0.752      | 
|POLY 6             |     P=0.545N     P=0.301N     P=0.271      P=0.477N    |P=0.620N     P=0.518      P=0.507N     P=0.731      | 
|LOGISTIC REGRESSION|     P=0.552      P=0.332N     P=0.226      P=0.648     |P=0.653      P=0.500      (e)          P=0.650      | 
|COCH-ARM / FISHERS |     P=0.271N     P=0.262N     P=0.218      P=0.262N    |P=0.593N     P=0.500      P=0.505N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.346N     (e)          (e)          (e)         |P=0.408N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    6/50 (12%)   1/50 (2%)   |0/50 (0%)    0/50 (0%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/33.30      2/32.24      6/34.92      1/27.66     |0/40.12      0/41.69      3/39.84      2/37.27      | 
|POLY-3 PERCENT (g) |     12.0%        6.2%         17.2%        3.6%        |0.0%         0.0%         7.5%         5.4%         | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    2/22 (9%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     525          652          547          638         |---          ---          694          711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.579      P=0.430N     P=0.402      P=0.725     |P=0.106      (e)          P=0.098      P=0.176      | 
|POLY 3             |     P=0.261N     P=0.349N     P=0.396      P=0.235N    |P=0.168      (e)          P=0.116      P=0.220      | 
|POLY 1.5           |     P=0.213N     P=0.339N     P=0.389      P=0.200N    |P=0.183      (e)          P=0.118      P=0.229      | 
|POLY 6             |     P=0.390N     P=0.373N     P=0.406      P=0.332N    |P=0.148      (e)          P=0.112      P=0.209      | 
|LOGISTIC REGRESSION|     P=0.278N     P=0.354N     P=0.384      P=0.298N    |P=0.143      (e)          P=0.108      P=0.199      | 
|COCH-ARM / FISHERS |     P=0.181N     P=0.339N     P=0.370      P=0.181N    |P=0.203      (e)          P=0.117      P=0.247      | 
|ORDER RESTRICTED   |     P=0.228N     (e)          (e)          (e)         |P=0.079      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    7/50 (14%)   4/50 (8%)   |1/50 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/33.13      1/31.75      7/35.43      4/28.88     |1/40.12      2/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     15.1%        3.2%         19.8%        13.9%       |2.5%         4.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |1/26 (4%)    2/26 (8%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     591          735 (T)      492          555         |735 (T)      735 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    P=0.186N     P=0.432      P=0.094     |P=0.329N     P=0.500      P=0.533N     P=0.597N     | 
|POLY 3             |     P=0.441      P=0.105N     P=0.424      P=0.589N    |P=0.250N     P=0.513      P=0.502N     P=0.516N     | 
|POLY 1.5           |     P=0.495      P=0.101N     P=0.409      P=0.535N    |P=0.245N     P=0.510      P=0.501N     P=0.508N     | 
|POLY 6             |     P=0.324      P=0.119N     P=0.445      P=0.582     |P=0.256N     P=0.518      P=0.507N     P=0.527N     | 
|LOGISTIC REGRESSION|     P=0.356      P=0.128N     P=0.396      P=0.523     |P=0.329N     P=0.500      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.536      P=0.102N     P=0.380      P=0.500N    |P=0.240N     P=0.500      P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.288      (e)          (e)          (e)         |P=0.190N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/33.31      1/32.26      0/33.30      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     6.0%         3.1%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     469          581          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.279N     P=0.514N     P=0.244N     P=0.457N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.228N     P=0.511N     P=0.236N     P=0.282N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.221N     P=0.503N     P=0.234N     P=0.255N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.236N     P=0.531N     P=0.240N     P=0.351N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.203N     P=0.516N     P=0.256N     P=0.229N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.212N     P=0.500N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.104N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous                                                                 | 
|     Tumor (malignant or NOS), or Carcinoma                                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/32.55      0/31.75      2/33.40      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     6.1%         0.0%         6.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     690          ---          708          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.918      P=0.316N     P=0.645N     P=0.970N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.335N     P=0.241N     P=0.687N     P=0.276N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.310N     P=0.237N     P=0.687N     P=0.252N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.395N     P=0.252N     P=0.692N     P=0.341N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.747N     P=0.275N     P=0.682N     P=0.762N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.290N     P=0.247N     P=0.691N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.147N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/32.38      2/32.12      0/33.30      0/27.31     |0/40.12      0/41.69      0/39.69      1/37.12      | 
|POLY-3 PERCENT (g) |     0.0%         6.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     ---          644          ---          ---         |---          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.701N     P=0.190      (e)          (e)         |P=0.152      (e)          (e)          P=0.403      | 
|POLY 3             |     P=0.415N     P=0.233      (e)          (e)         |P=0.214      (e)          (e)          P=0.484      | 
|POLY 1.5           |     P=0.400N     P=0.238      (e)          (e)         |P=0.221      (e)          (e)          P=0.492      | 
|POLY 6             |     P=0.438N     P=0.224      (e)          (e)         |P=0.205      (e)          (e)          P=0.473      | 
|LOGISTIC REGRESSION|     P=0.522N     P=0.216      (e)          (e)         |(e)          (e)          (e)          P=0.403      | 
|COCH-ARM / FISHERS |     P=0.390N     P=0.247      (e)          (e)         |P=0.229      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.280N     (e)          (e)          (e)         |P=0.107      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    8/50 (16%)   4/50 (8%)   |1/50 (2%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/33.13      3/32.12      8/35.53      4/28.88     |1/40.12      2/41.69      0/39.69      1/37.12      | 
|POLY-3 PERCENT (g) |     15.1%        9.3%         22.5%        13.9%       |2.5%         4.8%         0.0%         2.7%         | 
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |1/26 (4%)    2/26 (8%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     591          644          492          555         |735 (T)      735 (T)      ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053      P=0.515N     P=0.341      P=0.094     |P=0.653      P=0.500      P=0.533N     P=0.650      | 
|POLY 3             |     P=0.570      P=0.369N     P=0.314      P=0.589N    |P=0.610N     P=0.513      P=0.502N     P=0.744      | 
|POLY 1.5           |     P=0.548N     P=0.357N     P=0.302      P=0.535N    |P=0.603N     P=0.510      P=0.501N     P=0.752      | 
|POLY 6             |     P=0.428      P=0.402N     P=0.334      P=0.582     |P=0.620N     P=0.518      P=0.507N     P=0.731      | 
|LOGISTIC REGRESSION|     P=0.451      P=0.421N     P=0.290      P=0.523     |P=0.653      P=0.500      (e)          P=0.650      | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.357N     P=0.277      P=0.500N    |P=0.593N     P=0.500      P=0.505N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.391      (e)          (e)          (e)         |P=0.408N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    7/50 (14%)   4/50 (8%)   |1/50 (2%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/33.13      3/32.12      7/35.43      4/28.88     |1/40.12      2/41.69      0/39.69      1/37.12      | 
|POLY-3 PERCENT (g) |     15.1%        9.3%         19.8%        13.9%       |2.5%         4.8%         0.0%         2.7%         | 
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |1/26 (4%)    2/26 (8%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     591          644          492          555         |735 (T)      735 (T)      ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.065      P=0.515N     P=0.432      P=0.094     |P=0.653      P=0.500      P=0.533N     P=0.650      | 
|POLY 3             |     P=0.561      P=0.369N     P=0.424      P=0.589N    |P=0.610N     P=0.513      P=0.502N     P=0.744      | 
|POLY 1.5           |     P=0.565N     P=0.357N     P=0.409      P=0.535N    |P=0.603N     P=0.510      P=0.501N     P=0.752      | 
|POLY 6             |     P=0.429      P=0.402N     P=0.445      P=0.582     |P=0.620N     P=0.518      P=0.507N     P=0.731      | 
|LOGISTIC REGRESSION|     P=0.460      P=0.421N     P=0.396      P=0.523     |P=0.653      P=0.500      (e)          P=0.650      | 
|COCH-ARM / FISHERS |     P=0.519N     P=0.357N     P=0.380      P=0.500N    |P=0.593N     P=0.500      P=0.505N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.468      (e)          (e)          (e)         |P=0.408N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Sebaceous Gland                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/33.22      0/31.75      0/33.30      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     6.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     522          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414N     P=0.266N     P=0.257N     P=0.417N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.310N     P=0.246N     P=0.235N     P=0.282N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.311N     P=0.239N     P=0.234N     P=0.255N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.297N     P=0.261N     P=0.239N     P=0.351N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.301N     P=0.240N     P=0.244N     P=0.234N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.308N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.048N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  35/50 (70%)  37/50 (74%)  32/50 (64%) |                                                    | 
|POLY-3 RATE (b)    |     35/41.21     35/41.12     37/43.09     32/40.39    |                                                    | 
|POLY-3 PERCENT (g) |     84.9%        85.1%        85.9%        79.2%       |                                                    | 
|TERMINAL (d)       |     7/8 (88%)    5/5 (100%)   9/9 (100%)   0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     469          477          428          469         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.272      P=0.537      P<0.001 **  |                                                    | 
|POLY 3             |     P=0.202N     P=0.644      P=0.594      P=0.316N    |                                                    | 
|POLY 1.5           |     P=0.207N     P=0.590N     P=0.536      P=0.294N    |                                                    | 
|POLY 6             |     P=0.262N     P=0.575      P=0.631      P=0.460N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.473N     P=0.605      P=0.509      P=0.529N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.244N     P=0.586N     P=0.412      P=0.335N    |                                                    | 
|ORDER RESTRICTED   |     P=0.273N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   6/49 (12%)   5/49 (10%)   0/47 (0%)   |7/49 (14%)   5/49 (10%)   6/47 (13%)   5/48 (10%)   | 
|POLY-3 RATE (b)    |     5/32.95      6/32.14      5/33.73      0/25.76     |7/40.72      5/41.52      6/39.41      5/37.17      | 
|POLY-3 PERCENT (g) |     15.2%        18.7%        14.8%        0.0%        |17.2%        12.0%        15.2%        13.5%        | 
|TERMINAL (d)       |     0/8 (0%)     3/5 (60%)    0/9 (0%)     0/0 (0%)    |3/26 (12%)   2/26 (8%)    3/22 (14%)   2/16 (13%)   | 
|FIRST INCIDENCE    |     522          571          554          ---         |477          679          547          438          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.184N     P=0.345      P=0.596N     P=0.291N    |P=0.493      P=0.360N     P=0.580N     P=0.584N     | 
|POLY 3             |     P=0.034N*    P=0.482      P=0.620N     P=0.053N    |P=0.500N     P=0.364N     P=0.526N     P=0.443N     | 
|POLY 1.5           |     P=0.024N*    P=0.498      P=0.619N     P=0.040N*   |P=0.471N     P=0.366N     P=0.520N     P=0.417N     | 
|POLY 6             |     P=0.073N     P=0.440      P=0.628N     P=0.099N    |P=0.544N     P=0.360N     P=0.542N     P=0.483N     | 
|LOGISTIC REGRESSION|     P=0.038N*    P=0.478      P=0.613N     P=0.050N    |P=0.457N     P=0.362N     P=0.529N     P=0.396N     | 
|COCH-ARM / FISHERS |     P=0.019N*    P=0.500      P=0.630N     P=0.031N*   |P=0.434N     P=0.380N     P=0.533N     P=0.394N     | 
|ORDER RESTRICTED   |     P=0.042N*    (e)          (e)          (e)         |P=0.506N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    1/49 (2%)    0/47 (0%)   |1/49 (2%)    1/49 (2%)    2/47 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/31.45      1/31.43      1/33.11      0/25.76     |1/39.61      1/41.44      2/38.89      0/36.11      | 
|POLY-3 PERCENT (g) |     0.0%         3.2%         3.0%         0.0%        |2.5%         2.4%         5.1%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    1/22 (5%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          644          554          ---         |609          677          616          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.611N     P=0.457      P=0.500      (e)         |P=0.374N     P=0.745N     P=0.484      P=0.516N     | 
|POLY 3             |     P=0.571N     P=0.500      P=0.510      (e)         |P=0.354N     P=0.751N     P=0.494      P=0.518N     | 
|POLY 1.5           |     P=0.548N     P=0.502      P=0.507      (e)         |P=0.340N     P=0.753N     P=0.494      P=0.511N     | 
|POLY 6             |     P=0.619N     P=0.494      P=0.514      (e)         |P=0.374N     P=0.747N     P=0.489      P=0.529N     | 
|LOGISTIC REGRESSION|     P=0.523N     P=0.499      P=0.464      (e)         |P=0.315N     P=0.750      P=0.470      P=0.503N     | 
|COCH-ARM / FISHERS |     P=0.532N     P=0.500      P=0.500      (e)         |P=0.322N     P=0.753N     P=0.484      P=0.505N     | 
|ORDER RESTRICTED   |     P=0.420      (e)          (e)          (e)         |P=0.293N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   7/49 (14%)   5/49 (10%)   0/47 (0%)   |8/49 (16%)   6/49 (12%)   8/47 (17%)   5/48 (10%)   | 
|POLY-3 RATE (b)    |     5/32.95      7/32.47      5/33.73      0/25.76     |8/41.15      6/41.74      8/39.83      5/37.17      | 
|POLY-3 PERCENT (g) |     15.2%        21.6%        14.8%        0.0%        |19.4%        14.4%        20.1%        13.5%        | 
|TERMINAL (d)       |     0/8 (0%)     3/5 (60%)    0/9 (0%)     0/0 (0%)    |3/26 (12%)   2/26 (8%)    4/22 (18%)   2/16 (13%)   | 
|FIRST INCIDENCE    |     522          571          554          ---         |477          677          547          438          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.158N     P=0.239      P=0.596N     P=0.291N    |P=0.534N     P=0.363N     P=0.523      P=0.471N     | 
|POLY 3             |     P=0.027N*    P=0.362      P=0.620N     P=0.053N    |P=0.367N     P=0.374N     P=0.582      P=0.342N     | 
|POLY 1.5           |     P=0.018N*    P=0.378      P=0.619N     P=0.040N*   |P=0.334N     P=0.374N     P=0.587      P=0.314N     | 
|POLY 6             |     P=0.060N     P=0.324      P=0.628N     P=0.099N    |P=0.420N     P=0.372N     P=0.565      P=0.386N     | 
|LOGISTIC REGRESSION|     P=0.029N*    P=0.357      P=0.613N     P=0.050N    |P=0.308N     P=0.377N     P=0.571      P=0.288N     | 
|COCH-ARM / FISHERS |     P=0.014N*    P=0.380      P=0.630N     P=0.031N*   |P=0.295N     P=0.387N     P=0.572      P=0.290N     | 
|ORDER RESTRICTED   |     P=0.032N*    (e)          (e)          (e)         |P=0.385N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    2/49 (4%)    0/47 (0%)   |0/49 (0%)    0/49 (0%)    0/47 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/31.45      0/31.10      2/32.70      0/25.76     |0/39.18      0/41.22      0/38.48      1/36.11      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.1%         0.0%        |0.0%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          692          ---         |---          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.729      (e)          P=0.267      (e)         |P=0.152      (e)          (e)          P=0.403      | 
|POLY 3             |     P=0.711N     (e)          P=0.244      (e)         |P=0.213      (e)          (e)          P=0.484      | 
|POLY 1.5           |     P=0.683N     (e)          P=0.243      (e)         |P=0.219      (e)          (e)          P=0.490      | 
|POLY 6             |     P=0.680      (e)          P=0.245      (e)         |P=0.205      (e)          (e)          P=0.475      | 
|LOGISTIC REGRESSION|     P=0.748      (e)          P=0.251      (e)         |(e)          (e)          (e)          P=0.403      | 
|COCH-ARM / FISHERS |     P=0.662N     (e)          P=0.247      (e)         |P=0.226      (e)          (e)          P=0.495      | 
|ORDER RESTRICTED   |     P=0.259      (e)          (e)          (e)         |P=0.106      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    1/49 (2%)    0/47 (0%)   |0/49 (0%)    2/49 (4%)    1/47 (2%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/31.45      0/31.10      1/32.61      0/25.76     |0/39.18      2/41.22      1/38.48      0/36.11      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         3.1%         0.0%        |0.0%         4.9%         2.6%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    2/26 (8%)    1/22 (5%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          716          ---         |---          735 (T)      735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.986      (e)          P=0.540      (e)         |P=0.486N     P=0.238      P=0.467      (e)          | 
|POLY 3             |     P=0.802N     (e)          P=0.507      (e)         |P=0.386N     P=0.248      P=0.496      (e)          | 
|POLY 1.5           |     P=0.789N     (e)          P=0.506      (e)         |P=0.378N     P=0.245      P=0.497      (e)          | 
|POLY 6             |     P=0.774      (e)          P=0.509      (e)         |P=0.397N     P=0.253      P=0.494      (e)          | 
|LOGISTIC REGRESSION|     P=0.915      (e)          P=0.516      (e)         |(e)          P=0.238      P=0.467      (e)          | 
|COCH-ARM / FISHERS |     P=0.780N     (e)          P=0.500      (e)         |P=0.371N     P=0.247      P=0.490      (e)          | 
|ORDER RESTRICTED   |     P=0.392      (e)          (e)          (e)         |P=0.335      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    3/49 (6%)    0/47 (0%)   |0/49 (0%)    2/49 (4%)    1/47 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/31.45      0/31.10      3/32.78      0/25.76     |0/39.18      2/41.22      1/38.48      1/36.11      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         9.2%         0.0%        |0.0%         4.9%         2.6%         2.8%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    2/26 (8%)    1/22 (5%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          692          ---         |---          735 (T)      735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481      (e)          P=0.152      (e)         |P=0.516      P=0.238      P=0.467      P=0.403      | 
|POLY 3             |     P=0.662N     (e)          P=0.123      (e)         |P=0.624      P=0.248      P=0.496      P=0.484      | 
|POLY 1.5           |     P=0.623N     (e)          P=0.123      (e)         |P=0.636      P=0.245      P=0.497      P=0.490      | 
|POLY 6             |     P=0.628      (e)          P=0.123      (e)         |P=0.607      P=0.253      P=0.494      P=0.475      | 
|LOGISTIC REGRESSION|     P=0.619      (e)          P=0.129      (e)         |(e)          P=0.238      P=0.467      P=0.403      | 
|COCH-ARM / FISHERS |     P=0.594N     (e)          P=0.121      (e)         |P=0.649      P=0.247      P=0.490      P=0.495      | 
|ORDER RESTRICTED   |     P=0.173      (e)          (e)          (e)         |P=0.281      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    3/50 (6%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/32.38      0/31.75      0/33.30      0/27.31     |0/40.12      3/42.43      0/39.69      2/37.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         7.1%         0.0%         5.3%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    2/26 (8%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          469          ---          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.328      P=0.124      (e)          P=0.211      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.403      P=0.128      (e)          P=0.222      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.413      P=0.126      (e)          P=0.230      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.389      P=0.132      (e)          P=0.212      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.434      P=0.109      (e)          P=0.230      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.424      P=0.121      (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.141      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/32.38      0/31.75      0/33.30      0/27.31     |0/40.12      2/41.69      0/39.69      1/37.22      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.8%         0.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    2/26 (8%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          735 (T)      ---          711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.534      P=0.238      (e)          P=0.459      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.615      P=0.245      (e)          P=0.485      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.625      P=0.243      (e)          P=0.493      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.602      P=0.248      (e)          P=0.474      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.567      P=0.238      (e)          P=0.471      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.634      P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.311      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   9/50 (18%)   6/49 (12%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |6/40.86      9/42.55      6/40.27      2/37.64      | 
|POLY-3 PERCENT (g) |                                                        |14.7%        21.2%        14.9%        5.3%         | 
|TERMINAL (d)       |                                                        |4/26 (15%)   5/26 (19%)   5/22 (23%)   0/16 (0%)    | 
|FIRST INCIDENCE    |                                                        |581          637          547          599          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.140N     P=0.316      P=0.527      P=0.273N     | 
|POLY 3             |                                                        |P=0.058N     P=0.314      P=0.612      P=0.158N     | 
|POLY 1.5           |                                                        |P=0.050N     P=0.307      P=0.618      P=0.145N     | 
|POLY 6             |                                                        |P=0.073N     P=0.326      P=0.593      P=0.179N     | 
|LOGISTIC REGRESSION|                                                        |P=0.059N     P=0.315      P=0.610      P=0.153N     | 
|COCH-ARM / FISHERS |                                                        |P=0.042N*    P=0.288      P=0.606      P=0.134N     | 
|ORDER RESTRICTED   |                                                        |P=0.083N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/40.12      0/41.69      0/39.69      2/38.56      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         0.0%         5.2%         | 
|TERMINAL (d)       |                                                        |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          ---          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.040 *    (e)          (e)          P=0.235      | 
|POLY 3             |                                                        |P=0.038 *    (e)          (e)          P=0.228      | 
|POLY 1.5           |                                                        |P=0.040 *    (e)          (e)          P=0.233      | 
|POLY 6             |                                                        |P=0.036 *    (e)          (e)          P=0.219      | 
|LOGISTIC REGRESSION|                                                        |P=0.044 *    (e)          (e)          P=0.190      | 
|COCH-ARM / FISHERS |                                                        |P=0.043 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |                                                        |P=0.026 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   9/50 (18%)   6/49 (12%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |6/40.86      9/42.55      6/40.27      4/39.07      | 
|POLY-3 PERCENT (g) |                                                        |14.7%        21.2%        14.9%        10.2%        | 
|TERMINAL (d)       |                                                        |4/26 (15%)   5/26 (19%)   5/22 (23%)   0/16 (0%)    | 
|FIRST INCIDENCE    |                                                        |581          637          547          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.395N     P=0.316      P=0.527      P=0.548N     | 
|POLY 3             |                                                        |P=0.200N     P=0.314      P=0.612      P=0.397N     | 
|POLY 1.5           |                                                        |P=0.185N     P=0.307      P=0.618      P=0.381N     | 
|POLY 6             |                                                        |P=0.225N     P=0.326      P=0.593      P=0.422N     | 
|LOGISTIC REGRESSION|                                                        |P=0.190N     P=0.315      P=0.610      P=0.361N     | 
|COCH-ARM / FISHERS |                                                        |P=0.171N     P=0.288      P=0.606      P=0.370N     | 
|ORDER RESTRICTED   |                                                        |P=0.269N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/40.57      1/42.37      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |                                                        |4.9%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |1/26 (4%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |                                                        |604          506          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.245N     P=0.495N     P=0.258N     P=0.305N     | 
|POLY 3             |                                                        |P=0.226N     P=0.485N     P=0.242N     P=0.257N     | 
|POLY 1.5           |                                                        |P=0.221N     P=0.489N     P=0.239N     P=0.247N     | 
|POLY 6             |                                                        |P=0.232N     P=0.480N     P=0.248N     P=0.272N     | 
|LOGISTIC REGRESSION|                                                        |P=0.201N     P=0.545N     P=0.242N     P=0.240N     | 
|COCH-ARM / FISHERS |                                                        |P=0.212N     P=0.500N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |                                                        |P=0.087N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/32.81      0/31.75      0/33.30      3/29.06     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     3.1%         0.0%         0.0%         10.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     609          ---          ---          347         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    P=0.487N     P=0.493N     P=0.249     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.039 *    P=0.507N     P=0.497N     P=0.259     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.043 *    P=0.501N     P=0.496N     P=0.288     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.031 *    P=0.519N     P=0.500N     P=0.196     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.056      P=0.501N     P=0.505N     P=0.304     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.048 *    P=0.500N     P=0.500N     P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.025 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 26      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/32.81      0/31.75      1/33.30      3/29.06     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     3.1%         0.0%         3.0%         10.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     609          ---          735 (T)      347         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023 *    P=0.487N     P=0.743N     P=0.249     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.064      P=0.507N     P=0.759N     P=0.259     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.073      P=0.501N     P=0.757N     P=0.288     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.047 *    P=0.519N     P=0.763      P=0.196     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.094      P=0.501N     P=0.757N     P=0.304     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.080      P=0.500N     P=0.753N     P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.057      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/32.38      0/31.75      2/33.55      0/27.31     |0/40.12      1/42.00      0/39.69      1/37.38      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.0%         0.0%        |0.0%         2.4%         0.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          666          ---         |---          651          ---          665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.724      (e)          P=0.258      (e)         |P=0.442      P=0.522      (e)          P=0.481      | 
|POLY 3             |     P=0.704N     (e)          P=0.244      (e)         |P=0.460      P=0.509      (e)          P=0.486      | 
|POLY 1.5           |     P=0.674N     (e)          P=0.243      (e)         |P=0.469      P=0.506      (e)          P=0.493      | 
|POLY 6             |     P=0.679      (e)          P=0.244      (e)         |P=0.449      P=0.513      (e)          P=0.476      | 
|LOGISTIC REGRESSION|     P=0.770      (e)          P=0.243      (e)         |P=0.485      P=0.491      (e)          P=0.498      | 
|COCH-ARM / FISHERS |     P=0.652N     (e)          P=0.247      (e)         |P=0.478      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.257      (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 27      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  31/50 (62%)  28/50 (56%)  15/50 (30%) |21/50 (42%)  19/50 (38%)  18/49 (37%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     29/42.74     31/41.18     28/42.51     15/35.58    |21/44.96     19/43.15     18/43.74     29/43.77     | 
|POLY-3 PERCENT (g) |     67.9%        75.3%        65.9%        42.2%       |46.7%        44.0%        41.2%        66.3%        | 
|TERMINAL (d)       |     6/8 (75%)    4/5 (80%)    6/9 (67%)    0/0 (0%)    |8/26 (31%)   9/26 (35%)   5/22 (23%)   12/16 (75%)  | 
|FIRST INCIDENCE    |     302          490          428          421         |456          628          518          438          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.534N     P=0.246      P=0.436N     P=0.548     |P<0.001 **   P=0.392N     P=0.487N     P=0.015 *    | 
|POLY 3             |     P<0.001N**   P=0.285      P=0.515N     P=0.011N*   |P=0.011 *    P=0.484N     P=0.375N     P=0.043 *    | 
|POLY 1.5           |     P<0.001N**   P=0.348      P=0.497N     P=0.005N**  |P=0.014 *    P=0.448N     P=0.360N     P=0.057      | 
|POLY 6             |     P=0.011N*    P=0.220      P=0.554N     P=0.055N    |P=0.008 **   P=0.523N     P=0.401N     P=0.031 *    | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.426      P=0.500N     P=0.003N**  |P=0.016 *    P=0.390N     P=0.385N     P=0.076      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.419      P=0.500N     P=0.004N**  |P=0.020 *    P=0.419N     P=0.371N     P=0.081      | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.019 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/33.08      2/32.13      1/33.30      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     9.1%         6.2%         3.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     561          627          735 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296N     P=0.623N     P=0.283N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.126N     P=0.514N     P=0.300N     P=0.154N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.113N     P=0.502N     P=0.299N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.155N     P=0.541N     P=0.306N     P=0.217N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.171N     P=0.524N     P=0.294N     P=0.188N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.103N     P=0.500N     P=0.309N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.081N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 28      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/33.08      2/32.13      1/33.30      0/27.31     |0/40.12      0/41.69      0/39.69      0/37.12      | 
|POLY-3 PERCENT (g) |     9.1%         6.2%         3.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    | 
|FIRST INCIDENCE    |     561          627          735 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296N     P=0.623N     P=0.283N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.126N     P=0.514N     P=0.300N     P=0.154N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.113N     P=0.502N     P=0.299N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.155N     P=0.541N     P=0.306N     P=0.217N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.171N     P=0.524N     P=0.294N     P=0.188N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.103N     P=0.500N     P=0.309N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.081N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/32.38      1/32.35      0/33.30      0/27.31     |0/40.12      0/41.69      2/40.40      1/37.12      | 
|POLY-3 PERCENT (g) |     0.0%         3.1%         0.0%         0.0%        |0.0%         0.0%         5.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     ---          543          ---          ---         |---          ---          628          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.609N     P=0.510      (e)          (e)         |P=0.357      (e)          P=0.240      P=0.403      | 
|POLY 3             |     P=0.618N     P=0.500      (e)          (e)         |P=0.378      (e)          P=0.238      P=0.484      | 
|POLY 1.5           |     P=0.613N     P=0.502      (e)          (e)         |P=0.397      (e)          P=0.238      P=0.492      | 
|POLY 6             |     P=0.620N     P=0.493      (e)          (e)         |P=0.350      (e)          P=0.236      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.598N     P=0.471      (e)          (e)         |P=0.421      (e)          P=0.210      P=0.403      | 
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.420      (e)          P=0.242      P=0.500      | 
|ORDER RESTRICTED   |     P=0.410N     (e)          (e)          (e)         |P=0.169      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 29      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/32.84      1/32.35      0/33.30      0/27.31     |0/40.12      0/41.69      2/40.40      1/37.12      | 
|POLY-3 PERCENT (g) |     3.0%         3.1%         0.0%         0.0%        |0.0%         0.0%         5.0%         2.7%         | 
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    | 
|FIRST INCIDENCE    |     595          543          ---          ---         |---          ---          628          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.356N     P=0.751N     P=0.512N     P=0.512N    |P=0.357      (e)          P=0.240      P=0.403      | 
|POLY 3             |     P=0.366N     P=0.759      P=0.497N     P=0.537N    |P=0.378      (e)          P=0.238      P=0.484      | 
|POLY 1.5           |     P=0.358N     P=0.761N     P=0.497N     P=0.515N    |P=0.397      (e)          P=0.238      P=0.492      | 
|POLY 6             |     P=0.373N     P=0.750      P=0.501N     P=0.586N    |P=0.350      (e)          P=0.236      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.337N     P=0.750      P=0.510N     P=0.495N    |P=0.421      (e)          P=0.210      P=0.403      | 
|COCH-ARM / FISHERS |     P=0.348N     P=0.753N     P=0.500N     P=0.500N    |P=0.420      (e)          P=0.242      P=0.500      | 
|ORDER RESTRICTED   |     P=0.285N     (e)          (e)          (e)         |P=0.169      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  50/50 (100%) 49/50 (98%)  47/50 (94%) |48/50 (96%)  47/50 (94%)  46/49 (94%)  43/50 (86%)  | 
|POLY-3 RATE (b)    |     47/47.32     50/50.00     49/49.28     47/47.65    |48/48.24     47/48.67     46/47.55     43/45.83     | 
|POLY-3 PERCENT (g) |     99.3%        100.0%       99.4%        98.6%       |99.5%        96.6%        96.8%        93.8%        | 
|TERMINAL (d)       |     8/8 (100%)   5/5 (100%)   9/9 (100%)   0/0 (0%)    |26/26 (100%) 25/26 (96%)  22/22 (100%) 16/16 (100%) | 
|FIRST INCIDENCE    |     333          399          428          469         |470          469          546          438          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.191      P=0.540      P<0.001 **  |P=0.068      P=0.431N     P=0.387      P=0.144      | 
|POLY 3             |     P=0.606N     P=1.000      P=0.997      P=0.925N    |P=0.113N     P=0.358N     P=0.376N     P=0.092N     | 
|POLY 1.5           |     P=0.337N     P=0.508      P=0.754      P=0.734N    |P=0.052N     P=0.338N     P=0.331N     P=0.053N     | 
|POLY 6             |     P=1.000N     P=1.000      P=1.000N     P=1.000N    |P=0.311N     P=0.423N     P=0.550N     P=0.263N     | 
|LOGISTIC REGRESSION|     P=0.102N     P=0.698      P=0.669N     P=0.297N    |P=0.115N     P=0.295N     P=0.147N     P=0.088N     | 
|COCH-ARM / FISHERS |     P=0.288N     P=0.121      P=0.309      P=0.661N    |P=0.038N*    P=0.500N     P=0.490N     P=0.080N     | 
|ORDER RESTRICTED   |     P=0.155N     (e)          (e)          (e)         |P=0.036N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 05                                            Page 30      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                     FURFURYL ALCOHOL       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  35/50 (70%)  34/50 (68%)  26/50 (52%) |31/50 (62%)  28/50 (56%)  32/49 (65%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     35/45.06     35/42.94     34/44.29     26/40.95    |31/45.89     28/47.32     32/46.75     36/46.27     | 
|POLY-3 PERCENT (g) |     77.7%        81.5%        76.8%        63.5%       |67.6%        59.2%        68.5%        77.8%        | 
|TERMINAL (d)       |     6/8 (75%)    5/5 (100%)   7/9 (78%)    0/0 (0%)    |15/26 (58%)  10/26 (39%)  12/22 (55%)  13/16 (81%)  | 
|FIRST INCIDENCE    |     302          399          428          347         |456          428          518          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.063      P=0.328      P=0.435N     P=0.101     |P=0.007 **   P=0.337N     P=0.333      P=0.028 *    | 
|POLY 3             |     P=0.023N*    P=0.419      P=0.565N     P=0.086N    |P=0.058      P=0.262N     P=0.553      P=0.181      | 
|POLY 1.5           |     P=0.016N*    P=0.502      P=0.529N     P=0.057N    |P=0.069      P=0.279N     P=0.528      P=0.195      | 
|POLY 6             |     P=0.081N     P=0.314      P=0.616N     P=0.220N    |P=0.047 *    P=0.243N     P=0.581      P=0.165      | 
|LOGISTIC REGRESSION|     P=0.018N*    P=0.579N     P=0.499N     P=0.023N*   |P=0.096      P=0.345N     P=0.448      P=0.183      | 
|COCH-ARM / FISHERS |     P=0.019N*    P=0.586N     P=0.500N     P=0.050N    |P=0.089      P=0.342N     P=0.447      P=0.198      | 
|ORDER RESTRICTED   |     P=0.035N*    (e)          (e)          (e)         |P=0.093      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%)|49/50 (98%)  49/50 (98%)  49/49 (100%) 49/50 (98%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     50/50.00     50/50.00    |49/49.00     49/50.00     49/49.00     49/49.07     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |100.0%       98.0%        100.0%       99.9%        | 
|TERMINAL (d)       |     8/8 (100%)   5/5 (100%)   9/9 (100%)   0/0 (0%)    |26/26 (100%) 25/26 (96%)  22/22 (100%) 16/16 (100%) | 
|FIRST INCIDENCE    |     302          399          428          347         |456          428          518          429          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.015 *    P=0.491N     P=0.289      P=0.044 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.649      P=0.505N     P=1.000      P=1.000N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.742      P=0.523N     P=1.000      P=0.998N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.609      P=0.504N     P=1.000      P=1.000N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.722N     P=0.605N     (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.668N     P=0.753N     P=0.505      P=0.753N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.407      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.