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TDMS Study 88139-06 Pathology Tables

NTP Experiment-Test: 88139-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97
Route: GAVAGE                                                                                                     Time: 14:53:58

                                                       13 WEEK SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  56-93-9

       Lock Date:  05/18/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88139-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:53:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                                                                          1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10            9                        
  Animals Examined Microscopically                    10                                                  10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                (10)                      
      Inflammation, Chronic, Focal                     1 (10%)                                                                      
      Necrosis, Focal                                  2 (20%)                                             1 (10%)                  
      Hepatocyte, Centrilobular, Hypertrophy           3 (30%)                                             3 (30%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                (10)                      
      Bilateral, Capsule, Hyperplasia, Focal           5 (50%)                                             5 (50%)                  
      Capsule, Hyperplasia, Focal                      1 (10%)                                                                      
   Thyroid Gland                                      (10)                                                (10)                      
      Ultimobranchial Cyst                                                                                 1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)                                                (10)                      
      Hemorrhage                                                                                           1 (10%)                  
   Uterus                                             (10)                                                (10)                      
      Endometrium, Hyperplasia, Cystic                 3 (30%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 88139-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:53:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                (10)                      
      Hemorrhage                                                                                           1 (10%)                  
      Hyperplasia, Lymphoid                            1 (10%)                                                                      
   Lymph Node, Mesenteric                             (10)                                                (10)                      
      Hyperplasia, Lymphoid                            1 (10%)                                                                      
   Spleen                                             (10)                                                (10)                      
      Hematopoietic Cell Proliferation                 1 (10%)                                             3 (30%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                (10)                      
      Interstitium, Inflammation, Chronic              1 (10%)                                             2 (20%)                  
   Nose                                               (10)                                                (10)                      
      Olfactory Epithelium, Cytoplasmic Alteration                                                         1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Urinary Bladder                                    (10)                                                (10)                      
      Infiltration Cellular, Lymphocyte                                                                    1 (10%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 88139-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:53:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                                                                          1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10            9            9                        
    Accidently Killed                                                                         1                                     
  Animals Examined Microscopically                    10                                                  10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                (10)                      
      Inflammation, Chronic, Focal                                                                         1 (10%)                  
      Hepatocyte, Centrilobular, Hypertrophy           3 (30%)                                             3 (30%)                  
   Salivary Glands                                    (10)                                                (10)                      
      Infiltration Cellular, Focal, Lymphocyte         1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                (10)                      
      Capsule, Hyperplasia, Focal                                                                          1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (10)                                                (10)                      
      Infiltration Cellular, Lymphocyte                1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 88139-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                      BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC)                          Date: 05/12/97  
Route: GAVAGE                                                                                                     Time: 14:53:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      12.5         25.0         50.0         100.0                        
                                                                MG/KG        MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                (10)                      
      Hematopoietic Cell Proliferation                 1 (10%)                                             1 (10%)                  
      Lymphoid Follicle, Hyperplasia                                                                       2 (20%)                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
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