National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17935

TDMS Study 05201-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 11/15/04       
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 14:19:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 98-00-0         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #2 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 11/15/04       
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 14:19:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 98-00-0         
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Brain                                                                              
                                                 Epididymis                                                                         
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 11/15/04       
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 14:19:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 98-00-0         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                    FURFURYL ALCOHOL                                                                              
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Adenoma                                                                                      
Kidney: Renal Tubule                   Adenoma                                                                                      
                                       Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Liver                                  Hemangiosarcoma                                                                              
All Organs                             Hemangiosarcoma or Hemangioma                                                                
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
===============================================================                                                                     
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                     FURFURYL ALCOHOL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/49 (4%)    0/49 (0%)    1/48 (2%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     6/43.80      2/42.82      0/38.96      1/44.13     |0/43.20      2/42.18      0/43.06      1/46.16      | 
|POLY-3 PERCENT (g) |     13.7%        4.7%         0.0%         2.3%        |0.0%         4.7%         0.0%         2.2%         | 
|TERMINAL (d)       |     4/34 (12%)   2/36 (6%)    0/30 (0%)    0/37 (0%)   |0/34 (0%)    2/33 (6%)    0/32 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     567          733 (T)      ---          646         |---          734 (T)      ---          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.123N     P=0.028N*    P=0.049N*   |P=0.678      P=0.232      (e)          P=0.532      | 
|POLY 3             |     P=0.094N     P=0.139N     P=0.022N*    P=0.054N    |P=0.655      P=0.232      (e)          P=0.513      | 
|POLY 1.5           |     P=0.100N     P=0.140N     P=0.020N*    P=0.058N    |P=0.645      P=0.231      (e)          P=0.507      | 
|POLY 6             |     P=0.087N     P=0.139N     P=0.025N*    P=0.050N    |P=0.667      P=0.234      (e)          P=0.520      | 
|LOGISTIC REGRESSION|     P=0.107N     P=0.137N     P=0.022N*    P=0.066N    |(e)          P=0.232      (e)          P=0.532      | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.141N     P=0.014N*    P=0.062N    |P=0.631      P=0.242      (e)          P=0.495      | 
|ORDER RESTRICTED   |     P=0.004N**   (e)          (e)          (e)         |P=0.318      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    1/49 (2%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.82      0/38.96      0/45.78     |2/43.50      1/42.18      0/42.25      1/46.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         2.4%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |1/34 (3%)    1/33 (3%)    0/32 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |651          734 (T)      ---          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.503N     P=0.510N     P=0.249N     P=0.449N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.546N     P=0.511N     P=0.243N     P=0.479N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.553N     P=0.511N     P=0.242N     P=0.490N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.537N     P=0.508N     P=0.246N     P=0.469N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.539N     P=0.508N     P=0.242N     P=0.501N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.566N     P=0.508N     P=0.253N     P=0.508N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.211N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    5/50 (10%)   2/50 (4%)   |2/50 (4%)    2/49 (4%)    5/50 (10%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     3/43.10      3/43.23      5/39.96      2/45.85     |2/43.29      2/42.18      5/43.22      5/47.11      | 
|POLY-3 PERCENT (g) |     7.0%         6.9%         12.5%        4.4%        |4.6%         4.7%         11.6%        10.6%        | 
|TERMINAL (d)       |     3/34 (9%)    2/36 (6%)    4/30 (13%)   1/38 (3%)   |1/34 (3%)    2/33 (6%)    4/32 (13%)   4/40 (10%)   | 
|FIRST INCIDENCE    |     733 (T)      632          317          716         |712          734 (T)      693          600          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319N     P=0.642N     P=0.296      P=0.448N    |P=0.256      P=0.686      P=0.193      P=0.284      | 
|POLY 3             |     P=0.330N     P=0.661N     P=0.315      P=0.472N    |P=0.211      P=0.685      P=0.215      P=0.252      | 
|POLY 1.5           |     P=0.346N     P=0.660      P=0.330      P=0.484N    |P=0.195      P=0.684      P=0.216      P=0.238      | 
|POLY 6             |     P=0.313N     P=0.656N     P=0.300      P=0.458N    |P=0.228      P=0.689      P=0.210      P=0.267      | 
|LOGISTIC REGRESSION|     P=0.359N     P=0.663      P=0.340      P=0.449N    |P=0.214      P=0.696N     P=0.204      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.372N     P=0.661N     P=0.357      P=0.500N    |P=0.168      P=0.684      P=0.218      P=0.218      | 
|ORDER RESTRICTED   |     P=0.343N     (e)          (e)          (e)         |P=0.197      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.85      0/42.87      0/39.04      1/45.88     |0/43.20      2/42.87      0/43.06      1/46.65      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         2.2%        |0.0%         4.7%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     465          ---          ---          707         |---          525          ---          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.544      P=0.508N     P=0.513N     P=0.743N    |P=0.666      P=0.236      (e)          P=0.532      | 
|POLY 3             |     P=0.540      P=0.504N     P=0.523N     P=0.750N    |P=0.658      P=0.235      (e)          P=0.515      | 
|POLY 1.5           |     P=0.534      P=0.504N     P=0.515N     P=0.755N    |P=0.649      P=0.233      (e)          P=0.510      | 
|POLY 6             |     P=0.547      P=0.504N     P=0.530N     P=0.745N    |P=0.669      P=0.240      (e)          P=0.521      | 
|LOGISTIC REGRESSION|     P=0.472      P=0.375N     P=0.329N     P=0.728     |P=0.600      P=0.248      (e)          P=0.532      | 
|COCH-ARM / FISHERS |     P=0.522      P=0.500N     P=0.500N     P=0.753N    |P=0.636      P=0.242      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.397N     (e)          (e)          (e)         |P=0.319      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    5/50 (10%)   3/50 (6%)   |2/50 (4%)    4/49 (8%)    5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     4/43.85      3/43.23      5/39.96      3/45.95     |2/43.29      4/42.87      5/43.22      6/47.11      | 
|POLY-3 PERCENT (g) |     9.1%         6.9%         12.5%        6.5%        |4.6%         9.3%         11.6%        12.7%        | 
|TERMINAL (d)       |     3/34 (9%)    2/36 (6%)    4/30 (13%)   1/38 (3%)   |1/34 (3%)    2/33 (6%)    4/32 (13%)   5/40 (13%)   | 
|FIRST INCIDENCE    |     465          632          317          707         |712          525          693          600          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.406N     P=0.483N     P=0.434      P=0.444N    |P=0.262      P=0.331      P=0.193      P=0.192      | 
|POLY 3             |     P=0.427N     P=0.508N     P=0.442      P=0.474N    |P=0.210      P=0.332      P=0.215      P=0.162      | 
|POLY 1.5           |     P=0.444N     P=0.508N     P=0.463      P=0.486N    |P=0.194      P=0.328      P=0.216      P=0.151      | 
|POLY 6             |     P=0.408N     P=0.504N     P=0.422      P=0.460N    |P=0.227      P=0.340      P=0.210      P=0.175      | 
|LOGISTIC REGRESSION|     P=0.478N     P=0.498N     P=0.527      P=0.511N    |P=0.195      P=0.326      P=0.204      P=0.153      | 
|COCH-ARM / FISHERS |     P=0.471N     P=0.500N     P=0.500      P=0.500N    |P=0.166      P=0.329      P=0.218      P=0.134      | 
|ORDER RESTRICTED   |     P=0.488N     (e)          (e)          (e)         |P=0.145      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    2/48 (4%)    0/48 (0%)   |1/49 (2%)    0/48 (0%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/43.64      1/42.82      2/39.34      0/44.13     |1/42.20      0/41.96      1/42.25      1/46.16      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         5.1%         0.0%        |2.4%         0.0%         2.4%         2.2%         | 
|TERMINAL (d)       |     1/34 (3%)    1/36 (3%)    0/30 (0%)    0/38 (0%)   |1/33 (3%)    0/33 (0%)    1/32 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     567          733 (T)      576          ---         |734 (T)      ---          734 (T)      734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.194N     P=0.482N     P=0.648      P=0.218N    |P=0.617      P=0.500N     P=0.755      P=0.718N     | 
|POLY 3             |     P=0.203N     P=0.507N     P=0.656      P=0.235N    |P=0.592      P=0.501N     P=0.761N     P=0.740N     | 
|POLY 1.5           |     P=0.210N     P=0.507N     P=0.664      P=0.240N    |P=0.583      P=0.503N     P=0.760N     P=0.748N     | 
|POLY 6             |     P=0.196N     P=0.506N     P=0.651      P=0.229N    |P=0.601      P=0.497N     P=0.760      P=0.731N     | 
|LOGISTIC REGRESSION|     P=0.231N     P=0.508N     P=0.677N     P=0.267N    |P=0.617      (e)          P=0.755      P=0.718N     | 
|COCH-ARM / FISHERS |     P=0.219N     P=0.508N     P=0.676      P=0.258N    |P=0.566      P=0.505N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.153N     (e)          (e)          (e)         |P=0.548      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.82      0/38.96      2/45.78     |0/43.20      0/41.96      0/42.25      0/46.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.257     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.034 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.82      0/38.96      2/45.78     |0/43.20      0/41.96      0/42.25      0/46.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.257     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.034 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    4/50 (8%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.82      0/38.96      4/45.78     |0/43.20      0/41.96      0/42.25      0/46.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         8.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    4/38 (11%)  |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   (e)          (e)          P=0.078     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.002 **   (e)          (e)          P=0.068     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.002 **   (e)          (e)          P=0.065     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.002 **   (e)          (e)          P=0.072     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.078     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.002 **   (e)          (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.003 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.10      5/43.39      0/38.96      3/46.12     |0/43.20      0/42.18      0/42.25      1/46.16      | 
|POLY-3 PERCENT (g) |     0.0%         11.5%        0.0%         6.5%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    3/36 (8%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          632          ---          637         |---          ---          ---          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.448      P=0.039 *    (e)          P=0.142     |P=0.262      (e)          (e)          P=0.532      | 
|POLY 3             |     P=0.428      P=0.031 *    (e)          P=0.131     |P=0.241      (e)          (e)          P=0.513      | 
|POLY 1.5           |     P=0.411      P=0.030 *    (e)          P=0.126     |P=0.236      (e)          (e)          P=0.507      | 
|POLY 6             |     P=0.450      P=0.032 *    (e)          P=0.138     |P=0.246      (e)          (e)          P=0.520      | 
|LOGISTIC REGRESSION|     P=0.413      P=0.033 *    (e)          P=0.121     |(e)          (e)          (e)          P=0.532      | 
|COCH-ARM / FISHERS |     P=0.390      P=0.028 *    (e)          P=0.121     |P=0.226      (e)          (e)          P=0.495      | 
|ORDER RESTRICTED   |     P=0.100      (e)          (e)          (e)         |P=0.132      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  13/50 (26%)  10/49 (20%)  13/50 (26%) |7/50 (14%)   7/49 (14%)   9/49 (18%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     13/43.10     13/44.81     10/40.56     13/47.36    |7/43.75      7/42.54      9/43.30      5/46.16      | 
|POLY-3 PERCENT (g) |     30.2%        29.0%        24.7%        27.5%       |16.0%        16.5%        20.8%        10.8%        | 
|TERMINAL (d)       |     13/34 (38%)  10/36 (28%)  7/30 (23%)   9/38 (24%)  |5/34 (15%)   5/33 (15%)   5/32 (16%)   5/40 (13%)   | 
|FIRST INCIDENCE    |     733 (T)      433          471          582         |595          649          621          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.461N     P=0.531N     P=0.439N     P=0.456N    |P=0.177N     P=0.596      P=0.363      P=0.280N     | 
|POLY 3             |     P=0.483N     P=0.546N     P=0.374N     P=0.479N    |P=0.226N     P=0.592      P=0.382      P=0.342N     | 
|POLY 1.5           |     P=0.529N     P=0.570N     P=0.364N     P=0.527N    |P=0.248N     P=0.590      P=0.380      P=0.361N     | 
|POLY 6             |     P=0.426N     P=0.517N     P=0.380N     P=0.421N    |P=0.207N     P=0.601      P=0.385      P=0.323N     | 
|LOGISTIC REGRESSION|     P=0.548N     P=0.584      P=0.425N     P=0.527N    |P=0.226N     P=0.599      P=0.374      P=0.322N     | 
|COCH-ARM / FISHERS |     P=0.526      P=0.590N     P=0.337N     P=0.590N    |P=0.290N     P=0.597      P=0.376      P=0.394N     | 
|ORDER RESTRICTED   |     P=0.525N     (e)          (e)          (e)         |P=0.290N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  19/50 (38%)  14/49 (29%)  13/50 (26%) |9/50 (18%)   15/49 (31%)  5/49 (10%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |     15/48.08     19/47.68     14/45.44     13/48.28    |9/43.66      15/43.50     5/43.08      8/46.66      | 
|POLY-3 PERCENT (g) |     31.2%        39.9%        30.8%        26.9%       |20.6%        34.5%        11.6%        17.1%        | 
|TERMINAL (d)       |     3/34 (9%)    9/36 (25%)   3/30 (10%)   5/38 (13%)  |6/34 (18%)   11/33 (33%)  1/32 (3%)    7/40 (18%)   | 
|FIRST INCIDENCE    |     465          270          400          382         |651          525          665          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.177N     P=0.327      P=0.531      P=0.327N    |P=0.133N     P=0.118      P=0.237N     P=0.369N     | 
|POLY 3             |     P=0.208N     P=0.251      P=0.572N     P=0.407N    |P=0.174N     P=0.111      P=0.198N     P=0.440N     | 
|POLY 1.5           |     P=0.213N     P=0.254      P=0.554N     P=0.408N    |P=0.198N     P=0.106      P=0.200N     P=0.469N     | 
|POLY 6             |     P=0.203N     P=0.249      P=0.581      P=0.406N    |P=0.153N     P=0.121      P=0.196N     P=0.411N     | 
|LOGISTIC REGRESSION|     P=0.402N     P=0.265      P=0.276N     P=0.596N    |P=0.191N     P=0.105      P=0.205N     P=0.441N     | 
|COCH-ARM / FISHERS |     P=0.223N     P=0.263      P=0.526N     P=0.412N    |P=0.244N     P=0.109      P=0.205N     P=0.518N     | 
|ORDER RESTRICTED   |     P=0.288N     (e)          (e)          (e)         |P=0.089N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  19/50 (38%)  14/49 (29%)  13/50 (26%) |9/50 (18%)   15/49 (31%)  5/49 (10%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |     15/48.08     19/47.68     14/45.44     13/48.28    |9/43.66      15/43.50     5/43.08      8/46.66      | 
|POLY-3 PERCENT (g) |     31.2%        39.9%        30.8%        26.9%       |20.6%        34.5%        11.6%        17.1%        | 
|TERMINAL (d)       |     3/34 (9%)    9/36 (25%)   3/30 (10%)   5/38 (13%)  |6/34 (18%)   11/33 (33%)  1/32 (3%)    7/40 (18%)   | 
|FIRST INCIDENCE    |     465          270          400          382         |651          525          665          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.177N     P=0.327      P=0.531      P=0.327N    |P=0.133N     P=0.118      P=0.237N     P=0.369N     | 
|POLY 3             |     P=0.208N     P=0.251      P=0.572N     P=0.407N    |P=0.174N     P=0.111      P=0.198N     P=0.440N     | 
|POLY 1.5           |     P=0.213N     P=0.254      P=0.554N     P=0.408N    |P=0.198N     P=0.106      P=0.200N     P=0.469N     | 
|POLY 6             |     P=0.203N     P=0.249      P=0.581      P=0.406N    |P=0.153N     P=0.121      P=0.196N     P=0.411N     | 
|LOGISTIC REGRESSION|     P=0.402N     P=0.265      P=0.276N     P=0.596N    |P=0.191N     P=0.105      P=0.205N     P=0.441N     | 
|COCH-ARM / FISHERS |     P=0.223N     P=0.263      P=0.526N     P=0.412N    |P=0.244N     P=0.109      P=0.205N     P=0.518N     | 
|ORDER RESTRICTED   |     P=0.288N     (e)          (e)          (e)         |P=0.089N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  27/50 (54%)  23/49 (47%)  22/50 (44%) |14/50 (28%)  19/49 (39%)  12/49 (24%)  12/49 (24%)  | 
|POLY-3 RATE (b)    |     28/48.08     27/47.68     23/46.31     22/48.86    |14/44.13     19/43.81     12/43.61     12/46.66     | 
|POLY-3 PERCENT (g) |     58.2%        56.6%        49.7%        45.0%       |31.7%        43.4%        27.5%        25.7%        | 
|TERMINAL (d)       |     16/34 (47%)  17/36 (47%)  10/30 (33%)  12/38 (32%) |10/34 (29%)  14/33 (42%)  6/32 (19%)   11/40 (28%)  | 
|FIRST INCIDENCE    |     465          270          400          382         |595          525          621          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.099N     P=0.433N     P=0.434N     P=0.113N    |P=0.087N     P=0.188      P=0.469N     P=0.254N     | 
|POLY 3             |     P=0.108N     P=0.519N     P=0.264N     P=0.135N    |P=0.135N     P=0.179      P=0.421N     P=0.344N     | 
|POLY 1.5           |     P=0.119N     P=0.515N     P=0.257N     P=0.144N    |P=0.158N     P=0.173      P=0.426N     P=0.376N     | 
|POLY 6             |     P=0.096N     P=0.523N     P=0.274N     P=0.125N    |P=0.116N     P=0.196      P=0.416N     P=0.315N     | 
|LOGISTIC REGRESSION|     P=0.208N     P=0.488N     P=0.154N     P=0.210N    |P=0.140N     P=0.170      P=0.434N     P=0.333N     | 
|COCH-ARM / FISHERS |     P=0.140N     P=0.500N     P=0.242N     P=0.159N    |P=0.210N     P=0.178      P=0.433N     P=0.433N     | 
|ORDER RESTRICTED   |     P=0.145N     (e)          (e)          (e)         |P=0.169N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  27/50 (54%)  23/49 (47%)  22/50 (44%) |14/50 (28%)  19/49 (39%)  12/49 (24%)  12/49 (24%)  | 
|POLY-3 RATE (b)    |     28/48.08     27/47.68     23/46.31     22/48.86    |14/44.13     19/43.81     12/43.61     12/46.66     | 
|POLY-3 PERCENT (g) |     58.2%        56.6%        49.7%        45.0%       |31.7%        43.4%        27.5%        25.7%        | 
|TERMINAL (d)       |     16/34 (47%)  17/36 (47%)  10/30 (33%)  12/38 (32%) |10/34 (29%)  14/33 (42%)  6/32 (19%)   11/40 (28%)  | 
|FIRST INCIDENCE    |     465          270          400          382         |595          525          621          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.099N     P=0.433N     P=0.434N     P=0.113N    |P=0.087N     P=0.188      P=0.469N     P=0.254N     | 
|POLY 3             |     P=0.108N     P=0.519N     P=0.264N     P=0.135N    |P=0.135N     P=0.179      P=0.421N     P=0.344N     | 
|POLY 1.5           |     P=0.119N     P=0.515N     P=0.257N     P=0.144N    |P=0.158N     P=0.173      P=0.426N     P=0.376N     | 
|POLY 6             |     P=0.096N     P=0.523N     P=0.274N     P=0.125N    |P=0.116N     P=0.196      P=0.416N     P=0.315N     | 
|LOGISTIC REGRESSION|     P=0.208N     P=0.488N     P=0.154N     P=0.210N    |P=0.140N     P=0.170      P=0.434N     P=0.333N     | 
|COCH-ARM / FISHERS |     P=0.140N     P=0.500N     P=0.242N     P=0.159N    |P=0.210N     P=0.178      P=0.433N     P=0.433N     | 
|ORDER RESTRICTED   |     P=0.145N     (e)          (e)          (e)         |P=0.169N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  16/50 (32%)  10/49 (20%)  14/50 (28%) |2/50 (4%)    4/49 (8%)    8/49 (16%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     16/43.24     16/44.33     10/39.05     14/46.38    |2/43.36      4/42.51      8/42.25      0/46.65      | 
|POLY-3 PERCENT (g) |     37.0%        36.1%        25.6%        30.2%       |4.6%         9.4%         18.9%        0.0%         | 
|TERMINAL (d)       |     15/34 (44%)  13/36 (36%)  9/30 (30%)   12/38 (32%) |1/34 (3%)    2/33 (6%)    8/32 (25%)   0/40 (0%)    | 
|FIRST INCIDENCE    |     697          287          712          582         |693          649          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276N     P=0.518N     P=0.210N     P=0.271N    |P=0.056N     P=0.332      P=0.038 *    P=0.209N     | 
|POLY 3             |     P=0.312N     P=0.554N     P=0.189N     P=0.322N    |P=0.058N     P=0.328      P=0.040 *    P=0.221N     | 
|POLY 1.5           |     P=0.354N     P=0.570N     P=0.169N     P=0.360N    |P=0.065N     P=0.325      P=0.041 *    P=0.227N     | 
|POLY 6             |     P=0.267N     P=0.532N     P=0.211N     P=0.281N    |P=0.052N     P=0.334      P=0.037 *    P=0.215N     | 
|LOGISTIC REGRESSION|     P=0.293N     P=0.581      P=0.230N     P=0.291N    |P=0.062N     P=0.326      P=0.036 *    P=0.223N     | 
|COCH-ARM / FISHERS |     P=0.418N     P=0.585N     P=0.140N     P=0.414N    |P=0.084N     P=0.329      P=0.043 *    P=0.247N     | 
|ORDER RESTRICTED   |     P=0.282N     (e)          (e)          (e)         |P=0.033N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/50 (14%)   8/49 (16%)   8/50 (16%)  |4/50 (8%)    4/49 (8%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/43.28      7/42.87      8/40.22      8/45.85     |4/44.37      4/42.96      4/43.13      1/46.65      | 
|POLY-3 PERCENT (g) |     9.2%         16.3%        19.9%        17.5%       |9.0%         9.3%         9.3%         2.1%         | 
|TERMINAL (d)       |     3/34 (9%)    7/36 (19%)   6/30 (20%)   7/38 (18%)  |2/34 (6%)    3/33 (9%)    2/32 (6%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     687          733 (T)      502          716         |547          448          469          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.359      P=0.289      P=0.126      P=0.238     |P=0.089N     P=0.613      P=0.615      P=0.151N     | 
|POLY 3             |     P=0.324      P=0.254      P=0.140      P=0.205     |P=0.099N     P=0.626      P=0.628      P=0.164N     | 
|POLY 1.5           |     P=0.302      P=0.254      P=0.150      P=0.194     |P=0.105N     P=0.626      P=0.631      P=0.169N     | 
|POLY 6             |     P=0.349      P=0.255      P=0.132      P=0.219     |P=0.094N     P=0.629      P=0.622      P=0.158N     | 
|LOGISTIC REGRESSION|     P=0.337      P=0.263      P=0.145      P=0.229     |P=0.154N     P=0.637N     P=0.630      P=0.248N     | 
|COCH-ARM / FISHERS |     P=0.268      P=0.262      P=0.168      P=0.178     |P=0.117N     P=0.631      P=0.631      P=0.181N     | 
|ORDER RESTRICTED   |     P=0.168      (e)          (e)          (e)         |P=0.148N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  23/50 (46%)  17/49 (35%)  20/50 (40%) |6/50 (12%)   8/49 (16%)   11/49 (22%)  1/50 (2%)    | 
|POLY-3 RATE (b)    |     20/43.42     23/44.33     17/40.31     20/46.45    |6/44.53      8/43.28      11/43.13     1/46.65      | 
|POLY-3 PERCENT (g) |     46.1%        51.9%        42.2%        43.1%       |13.5%        18.5%        25.5%        2.1%         | 
|TERMINAL (d)       |     18/34 (53%)  20/36 (56%)  14/30 (47%)  17/38 (45%) |3/34 (9%)    5/33 (15%)   9/32 (28%)   1/40 (3%)    | 
|FIRST INCIDENCE    |     687          287          502          582         |547          448          469          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.277N     P=0.422      P=0.532N     P=0.394N    |P=0.011N*    P=0.364      P=0.124      P=0.045N*    | 
|POLY 3             |     P=0.332N     P=0.368      P=0.444N     P=0.470N    |P=0.011N*    P=0.364      P=0.122      P=0.049N*    | 
|POLY 1.5           |     P=0.387N     P=0.353      P=0.417N     P=0.517N    |P=0.013N*    P=0.364      P=0.128      P=0.051N     | 
|POLY 6             |     P=0.272N     P=0.386      P=0.473N     P=0.416N    |P=0.010N*    P=0.369      P=0.113      P=0.046N*    | 
|LOGISTIC REGRESSION|     P=0.306N     P=0.332      P=0.530N     P=0.421N    |P=0.019N*    P=0.376      P=0.133      P=0.078N     | 
|COCH-ARM / FISHERS |     P=0.468N     P=0.343      P=0.368N     P=0.581N    |P=0.019N*    P=0.371      P=0.133      P=0.056N     | 
|ORDER RESTRICTED   |     P=0.422N     (e)          (e)          (e)         |P=0.011N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/49 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.87      0/39.04      0/45.78     |0/43.20      2/42.63      1/43.41      0/46.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.7%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    1/33 (3%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          601          637          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.337N     P=0.236      P=0.510      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.342N     P=0.234      P=0.501      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.351N     P=0.232      P=0.501      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.332N     P=0.238      P=0.500      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.403N     P=0.236      P=0.497      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.364N     P=0.242      P=0.500      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.308N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/49 (2%)    3/48 (6%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |                                                        |2/43.20      1/42.37      3/41.85      2/46.59      | 
|POLY-3 PERCENT (g) |                                                        |4.6%         2.4%         7.2%         4.3%         | 
|TERMINAL (d)       |                                                        |2/34 (6%)    0/33 (0%)    1/31 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |                                                        |734 (T)      684          637          609          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.619N     P=0.507N     P=0.477      P=0.638N     | 
|POLY 3             |                                                        |P=0.616      P=0.507N     P=0.486      P=0.666N     | 
|POLY 1.5           |                                                        |P=0.597      P=0.509N     P=0.484      P=0.680N     | 
|POLY 6             |                                                        |P=0.634      P=0.501N     P=0.487      P=0.651N     | 
|LOGISTIC REGRESSION|                                                        |P=0.556      P=0.506N     P=0.480      P=0.690      | 
|COCH-ARM / FISHERS |                                                        |P=0.564      P=0.508N     P=0.480      P=0.684      | 
|ORDER RESTRICTED   |                                                        |P=0.492      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor Benign                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/49 (0%)    2/48 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/43.20      0/42.18      2/41.25      0/46.16      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.9%         0.0%         | 
|TERMINAL (d)       |                                                        |0/34 (0%)    0/33 (0%)    2/31 (7%)    0/40 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.603N     (e)          P=0.218      (e)          | 
|POLY 3             |                                                        |P=0.625N     (e)          P=0.227      (e)          | 
|POLY 1.5           |                                                        |P=0.635N     (e)          P=0.228      (e)          | 
|POLY 6             |                                                        |P=0.616N     (e)          P=0.224      (e)          | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.218      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.653N     (e)          P=0.237      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.239      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    1/48 (2%)    0/49 (0%)   |7/48 (15%)   7/48 (15%)   4/48 (8%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/41.82      1/37.96      0/44.78     |7/41.74      7/41.36      4/42.32      1/46.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.6%         0.0%        |16.8%        16.9%        9.5%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    0/35 (0%)    1/29 (3%)    0/37 (0%)   |7/33 (21%)   7/33 (21%)   2/32 (6%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |734 (T)      734 (T)      617          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.752N     (e)          P=0.468      (e)         |P=0.009N**   P=0.617      P=0.273N     P=0.016N*    | 
|POLY 3             |     P=0.763N     (e)          P=0.475      (e)         |P=0.011N*    P=0.608      P=0.251N     P=0.020N*    | 
|POLY 1.5           |     P=0.766N     (e)          P=0.481      (e)         |P=0.013N*    P=0.605      P=0.255N     P=0.023N*    | 
|POLY 6             |     P=0.759N     (e)          P=0.468      (e)         |P=0.009N**   P=0.614N     P=0.247N     P=0.018N*    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.468      (e)         |P=0.011N*    P=0.617      P=0.262N     P=0.016N*    | 
|COCH-ARM / FISHERS |     P=0.772N     (e)          P=0.490      (e)         |P=0.018N*    P=0.613N     P=0.262N     P=0.028N*    | 
|ORDER RESTRICTED   |     P=0.359      (e)          (e)          (e)         |P=0.016N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.10      2/42.87      0/39.04      0/45.78     |0/43.20      0/42.18      1/43.06      1/46.65      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         0.0%         0.0%        |0.0%         0.0%         2.3%         2.1%         | 
|TERMINAL (d)       |     0/34 (0%)    2/36 (6%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    1/32 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |---          ---          734 (T)      734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.371N     P=0.251      (e)          (e)         |P=0.396      (e)          P=0.488      P=0.532      | 
|POLY 3             |     P=0.371N     P=0.236      (e)          (e)         |P=0.377      (e)          P=0.499      P=0.515      | 
|POLY 1.5           |     P=0.380N     P=0.235      (e)          (e)         |P=0.368      (e)          P=0.500      P=0.510      | 
|POLY 6             |     P=0.362N     P=0.237      (e)          (e)         |P=0.384      (e)          P=0.497      P=0.521      | 
|LOGISTIC REGRESSION|     (e)          P=0.251      (e)          (e)         |(e)          (e)          P=0.488      P=0.532      | 
|COCH-ARM / FISHERS |     P=0.390N     P=0.247      (e)          (e)         |P=0.350      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.235N     (e)          (e)          (e)         |P=0.252      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/49 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.87      1/39.41      0/45.78     |1/43.20      1/42.18      2/43.71      1/46.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.5%         0.0%        |2.3%         2.4%         4.6%         2.1%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |1/34 (3%)    1/33 (3%)    0/32 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          630          ---         |734 (T)      734 (T)      621          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.749N     (e)          P=0.480      (e)         |P=0.570N     P=0.755      P=0.507      P=0.725N     | 
|POLY 3             |     P=0.762N     (e)          P=0.482      (e)         |P=0.598N     P=0.756      P=0.504      P=0.743N     | 
|POLY 1.5           |     P=0.766N     (e)          P=0.488      (e)         |P=0.609N     P=0.754      P=0.503      P=0.750N     | 
|POLY 6             |     P=0.758N     (e)          P=0.477      (e)         |P=0.588N     P=0.759      P=0.505      P=0.736N     | 
|LOGISTIC REGRESSION|     P=0.798N     (e)          P=0.526      (e)         |P=0.626N     P=0.755      P=0.499      P=0.725N     | 
|COCH-ARM / FISHERS |     P=0.772N     (e)          P=0.500      (e)         |P=0.629N     P=0.747      P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.365      (e)          (e)          (e)         |P=0.602      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.28      0/42.87      0/39.04      0/45.78     |1/43.20      0/42.18      1/43.06      2/47.16      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |2.3%         0.0%         2.3%         4.2%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |1/34 (3%)    0/33 (0%)    1/32 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     687          ---          ---          ---         |734 (T)      ---          734 (T)      609          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.522N     P=0.505N     P=0.546N     P=0.481N    |P=0.291      P=0.506N     P=0.748      P=0.550      | 
|POLY 3             |     P=0.534N     P=0.502N     P=0.521N     P=0.489N    |P=0.269      P=0.505N     P=0.760      P=0.531      | 
|POLY 1.5           |     P=0.538N     P=0.502N     P=0.513N     P=0.493N    |P=0.259      P=0.506N     P=0.761      P=0.519      | 
|POLY 6             |     P=0.529N     P=0.501N     P=0.527N     P=0.484N    |P=0.279      P=0.502N     P=0.758      P=0.544      | 
|LOGISTIC REGRESSION|     P=0.545N     P=0.500N     P=0.509N     P=0.505N    |P=0.242      (e)          P=0.748      P=0.466      | 
|COCH-ARM / FISHERS |     P=0.547N     P=0.500N     P=0.500N     P=0.500N    |P=0.240      P=0.505N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.111N     (e)          (e)          (e)         |P=0.257      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)   |0/50 (0%)    1/48 (2%)    2/49 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.82      1/38.96      0/45.78     |0/43.20      1/41.96      2/42.67      0/46.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.6%         0.0%        |0.0%         2.4%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    1/30 (3%)    0/38 (0%)   |0/34 (0%)    1/33 (3%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |---          734 (T)      665          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.751N     (e)          P=0.475      (e)         |P=0.429N     P=0.494      P=0.236      (e)          | 
|POLY 3             |     P=0.761N     (e)          P=0.480      (e)         |P=0.442N     P=0.494      P=0.234      (e)          | 
|POLY 1.5           |     P=0.765N     (e)          P=0.486      (e)         |P=0.454N     P=0.492      P=0.234      (e)          | 
|POLY 6             |     P=0.758N     (e)          P=0.474      (e)         |P=0.430N     P=0.498      P=0.234      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.475      (e)         |P=0.473N     P=0.494      P=0.233      (e)          | 
|COCH-ARM / FISHERS |     P=0.770N     (e)          P=0.495      (e)         |P=0.473N     P=0.490      P=0.242      (e)          | 
|ORDER RESTRICTED   |     P=0.364      (e)          (e)          (e)         |P=0.307N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      1/42.87      0/39.04      1/45.78     |0/43.20      0/42.18      4/43.06      0/46.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         2.2%        |0.0%         0.0%         9.3%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    0/30 (0%)    1/38 (3%)   |0/34 (0%)    0/33 (0%)    4/32 (13%)   0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      ---          733 (T)     |---          ---          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.503      P=0.511      (e)          P=0.522     |P=0.468N     (e)          P=0.055      (e)          | 
|POLY 3             |     P=0.496      P=0.499      (e)          P=0.512     |P=0.487N     (e)          P=0.059      (e)          | 
|POLY 1.5           |     P=0.489      P=0.498      (e)          P=0.507     |P=0.501N     (e)          P=0.060      (e)          | 
|POLY 6             |     P=0.505      P=0.500      (e)          P=0.518     |P=0.475N     (e)          P=0.058      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.511      (e)          P=0.522     |(e)          (e)          P=0.055      (e)          | 
|COCH-ARM / FISHERS |     P=0.478      P=0.500      (e)          P=0.500     |P=0.529N     (e)          P=0.059      (e)          | 
|ORDER RESTRICTED   |     P=0.263      (e)          (e)          (e)         |P=0.108      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      1/42.87      0/39.04      0/45.78     |0/43.20      0/42.18      3/43.06      0/46.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         0.0%         7.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    3/32 (9%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |---          ---          734 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.588N     P=0.511      (e)          (e)         |P=0.525N     (e)          P=0.110      (e)          | 
|POLY 3             |     P=0.595N     P=0.499      (e)          (e)         |P=0.545N     (e)          P=0.118      (e)          | 
|POLY 1.5           |     P=0.601N     P=0.498      (e)          (e)         |P=0.557N     (e)          P=0.119      (e)          | 
|POLY 6             |     P=0.588N     P=0.500      (e)          (e)         |P=0.535N     (e)          P=0.116      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.511      (e)          (e)         |(e)          (e)          P=0.110      (e)          | 
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.579N     (e)          P=0.121      (e)          | 
|ORDER RESTRICTED   |     P=0.369N     (e)          (e)          (e)         |P=0.162      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    1/49 (2%)    0/48 (0%)   |3/50 (6%)    1/49 (2%)    3/49 (6%)    5/49 (10%)   | 
|POLY-3 RATE (b)    |     1/43.64      0/42.82      1/38.96      0/43.82     |3/43.20      1/42.18      3/42.66      5/46.16      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.6%         0.0%        |6.9%         2.4%         7.0%         10.8%        | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    1/30 (3%)    0/37 (0%)   |3/34 (9%)    1/33 (3%)    2/32 (6%)    5/40 (13%)   | 
|FIRST INCIDENCE    |     567          ---          733 (T)      ---         |734 (T)      734 (T)      617          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.460N     P=0.491N     P=0.733      P=0.483N    |P=0.208      P=0.315N     P=0.648      P=0.448      | 
|POLY 3             |     P=0.473N     P=0.504N     P=0.735      P=0.499N    |P=0.159      P=0.313N     P=0.657      P=0.393      | 
|POLY 1.5           |     P=0.477N     P=0.504N     P=0.743      P=0.503N    |P=0.148      P=0.315N     P=0.656      P=0.375      | 
|POLY 6             |     P=0.467N     P=0.504N     P=0.727      P=0.495N    |P=0.170      P=0.309N     P=0.657      P=0.414      | 
|LOGISTIC REGRESSION|     P=0.501N     P=0.485N     P=0.755N     P=0.540N    |P=0.178      P=0.315N     P=0.652      P=0.448      | 
|COCH-ARM / FISHERS |     P=0.485N     P=0.505N     P=0.747      P=0.510N    |P=0.128      P=0.316N     P=0.651      P=0.346      | 
|ORDER RESTRICTED   |     P=0.250N     (e)          (e)          (e)         |P=0.192      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    1/49 (2%)    0/48 (0%)   |3/50 (6%)    2/49 (4%)    3/49 (6%)    5/49 (10%)   | 
|POLY-3 RATE (b)    |     1/43.64      0/42.82      1/38.96      0/43.82     |3/43.20      2/42.18      3/42.66      5/46.16      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.6%         0.0%        |6.9%         4.7%         7.0%         10.8%        | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    1/30 (3%)    0/37 (0%)   |3/34 (9%)    2/33 (6%)    2/32 (6%)    5/40 (13%)   | 
|FIRST INCIDENCE    |     567          ---          733 (T)      ---         |734 (T)      734 (T)      617          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.460N     P=0.491N     P=0.733      P=0.483N    |P=0.281      P=0.514N     P=0.648      P=0.448      | 
|POLY 3             |     P=0.473N     P=0.504N     P=0.735      P=0.499N    |P=0.223      P=0.511N     P=0.657      P=0.393      | 
|POLY 1.5           |     P=0.477N     P=0.504N     P=0.743      P=0.503N    |P=0.209      P=0.513N     P=0.656      P=0.375      | 
|POLY 6             |     P=0.467N     P=0.504N     P=0.727      P=0.495N    |P=0.238      P=0.505N     P=0.657      P=0.414      | 
|LOGISTIC REGRESSION|     P=0.501N     P=0.485N     P=0.755N     P=0.540N    |P=0.247      P=0.514N     P=0.652      P=0.448      | 
|COCH-ARM / FISHERS |     P=0.485N     P=0.505N     P=0.747      P=0.510N    |P=0.183      P=0.510N     P=0.651      P=0.346      | 
|ORDER RESTRICTED   |     P=0.250N     (e)          (e)          (e)         |P=0.292      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    3/49 (6%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |2/43.20      3/42.18      4/44.18      2/46.65      | 
|POLY-3 PERCENT (g) |                                                        |4.6%         7.1%         9.1%         4.3%         | 
|TERMINAL (d)       |                                                        |2/34 (6%)    3/33 (9%)    1/32 (3%)    2/40 (5%)    | 
|FIRST INCIDENCE    |                                                        |734 (T)      734 (T)      582          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.395N     P=0.486      P=0.339      P=0.635N     | 
|POLY 3             |                                                        |P=0.434N     P=0.489      P=0.347      P=0.666N     | 
|POLY 1.5           |                                                        |P=0.451N     P=0.487      P=0.343      P=0.676N     | 
|POLY 6             |                                                        |P=0.418N     P=0.495      P=0.351      P=0.655N     | 
|LOGISTIC REGRESSION|                                                        |P=0.459N     P=0.486      P=0.336      P=0.635N     | 
|COCH-ARM / FISHERS |                                                        |P=0.481N     P=0.490      P=0.339      P=0.691N     | 
|ORDER RESTRICTED   |                                                        |P=0.474N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/49 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.10      2/42.87      1/39.04      0/45.78     |0/43.20      1/42.18      1/43.06      2/46.65      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.6%         0.0%        |0.0%         2.4%         2.3%         4.3%         | 
|TERMINAL (d)       |     0/34 (0%)    2/36 (6%)    1/30 (3%)    0/38 (0%)   |0/34 (0%)    1/33 (3%)    1/32 (3%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |---          734 (T)      734 (T)      734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.342N     P=0.251      P=0.475      (e)         |P=0.273      P=0.494      P=0.488      P=0.275      | 
|POLY 3             |     P=0.345N     P=0.236      P=0.480      (e)         |P=0.241      P=0.495      P=0.499      P=0.255      | 
|POLY 1.5           |     P=0.354N     P=0.235      P=0.487      (e)         |P=0.232      P=0.494      P=0.500      P=0.248      | 
|POLY 6             |     P=0.334N     P=0.237      P=0.474      (e)         |P=0.250      P=0.498      P=0.497      P=0.262      | 
|LOGISTIC REGRESSION|     (e)          P=0.251      P=0.475      (e)         |(e)          P=0.494      P=0.488      P=0.275      | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.247      P=0.500      (e)         |P=0.217      P=0.495      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.301N     (e)          (e)          (e)         |P=0.132      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   3/50 (6%)    4/50 (8%)   |2/50 (4%)    2/49 (4%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.10      5/43.39      3/39.41      4/46.19     |2/43.50      2/42.18      4/43.87      2/46.65      | 
|POLY-3 PERCENT (g) |     2.3%         11.5%        7.6%         8.7%        |4.6%         4.7%         9.1%         4.3%         | 
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    2/30 (7%)    2/38 (5%)   |1/34 (3%)    2/33 (6%)    1/32 (3%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     733 (T)      632          630          637         |651          734 (T)      621          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.456      P=0.116      P=0.265      P=0.219     |P=0.481N     P=0.683      P=0.335      P=0.638N     | 
|POLY 3             |     P=0.431      P=0.102      P=0.273      P=0.200     |P=0.522N     P=0.683      P=0.341      P=0.669N     | 
|POLY 1.5           |     P=0.411      P=0.101      P=0.284      P=0.191     |P=0.537N     P=0.683      P=0.340      P=0.678N     | 
|POLY 6             |     P=0.456      P=0.106      P=0.265      P=0.212     |P=0.508N     P=0.686      P=0.340      P=0.659N     | 
|LOGISTIC REGRESSION|     P=0.416      P=0.102      P=0.270      P=0.190     |P=0.548N     P=0.688      P=0.337      P=0.676N     | 
|COCH-ARM / FISHERS |     P=0.381      P=0.102      P=0.309      P=0.181     |P=0.566N     P=0.684      P=0.339      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.158      (e)          (e)          (e)         |P=0.531      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    7/50 (14%)   4/50 (8%)    4/50 (8%)   |2/50 (4%)    3/49 (6%)    5/50 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/43.10      7/43.39      4/39.41      4/46.19     |2/43.50      3/42.18      5/43.87      4/46.65      | 
|POLY-3 PERCENT (g) |     2.3%         16.1%        10.2%        8.7%        |4.6%         7.1%         11.4%        8.6%         | 
|TERMINAL (d)       |     1/34 (3%)    5/36 (14%)   3/30 (10%)   2/38 (5%)   |1/34 (3%)    3/33 (9%)    2/32 (6%)    4/40 (10%)   | 
|FIRST INCIDENCE    |     733 (T)      632          630          637         |651          734 (T)      621          734 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.562N     P=0.040 *    P=0.147      P=0.219     |P=0.484      P=0.487      P=0.215      P=0.411      | 
|POLY 3             |     P=0.588N     P=0.030 *    P=0.152      P=0.200     |P=0.431      P=0.486      P=0.219      P=0.370      | 
|POLY 1.5           |     P=0.584      P=0.030 *    P=0.161      P=0.191     |P=0.412      P=0.486      P=0.218      P=0.358      | 
|POLY 6             |     P=0.560N     P=0.031 *    P=0.145      P=0.212     |P=0.448      P=0.489      P=0.218      P=0.382      | 
|LOGISTIC REGRESSION|     P=0.594N     P=0.032 *    P=0.146      P=0.190     |P=0.421      P=0.492      P=0.217      P=0.378      | 
|COCH-ARM / FISHERS |     P=0.549      P=0.030 *    P=0.181      P=0.181     |P=0.377      P=0.490      P=0.218      P=0.339      | 
|ORDER RESTRICTED   |     P=0.092      (e)          (e)          (e)         |P=0.274      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    1/49 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.10      0/42.87      2/39.04      0/45.78     |2/44.04      1/42.18      2/43.22      0/46.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.1%         0.0%        |4.5%         2.4%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    2/30 (7%)    0/38 (0%)   |0/34 (0%)    1/33 (3%)    1/32 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |566          734 (T)      693          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.624N     (e)          P=0.211      (e)         |P=0.183N     P=0.514N     P=0.681      P=0.218N     | 
|POLY 3             |     P=0.636N     (e)          P=0.215      (e)         |P=0.191N     P=0.515N     P=0.687      P=0.225N     | 
|POLY 1.5           |     P=0.642N     (e)          P=0.223      (e)         |P=0.198N     P=0.513N     P=0.691      P=0.229N     | 
|POLY 6             |     P=0.629N     (e)          P=0.209      (e)         |P=0.185N     P=0.515N     P=0.681      P=0.221N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.211      (e)         |P=0.225N     P=0.494N     P=0.694      P=0.354N     | 
|COCH-ARM / FISHERS |     P=0.652N     (e)          P=0.247      (e)         |P=0.210N     P=0.508N     P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.228      (e)          (e)          (e)         |P=0.146N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |6/50 (12%)   3/49 (6%)    5/50 (10%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     3/43.23      3/43.03      1/39.66      2/45.82     |6/44.72      3/42.20      5/43.41      8/47.25      | 
|POLY-3 PERCENT (g) |     6.9%         7.0%         2.5%         4.4%        |13.4%        7.1%         11.5%        16.9%        | 
|TERMINAL (d)       |     1/34 (3%)    2/36 (6%)    0/30 (0%)    1/38 (3%)   |2/34 (6%)    2/33 (6%)    4/32 (13%)   5/40 (13%)   | 
|FIRST INCIDENCE    |     712          693          532          724         |573          730          637          663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400N     P=0.640N     P=0.358N     P=0.449N    |P=0.258      P=0.261N     P=0.514N     P=0.498      | 
|POLY 3             |     P=0.416N     P=0.661      P=0.336N     P=0.474N    |P=0.193      P=0.271N     P=0.521N     P=0.430      | 
|POLY 1.5           |     P=0.430N     P=0.658      P=0.326N     P=0.484N    |P=0.178      P=0.265N     P=0.510N     P=0.415      | 
|POLY 6             |     P=0.402N     P=0.662N     P=0.346N     P=0.462N    |P=0.209      P=0.275N     P=0.539N     P=0.445      | 
|LOGISTIC REGRESSION|     P=0.429N     P=0.664N     P=0.306N     P=0.458N    |P=0.165      P=0.251N     P=0.500N     P=0.335      | 
|COCH-ARM / FISHERS |     P=0.452N     P=0.661N     P=0.309N     P=0.500N    |P=0.152      P=0.254N     P=0.500N     P=0.387      | 
|ORDER RESTRICTED   |     P=0.365N     (e)          (e)          (e)         |P=0.262      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  31/50 (62%)  25/50 (50%)  29/50 (58%) |23/50 (46%)  23/49 (47%)  29/50 (58%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     31/45.06     31/46.27     25/42.41     29/47.85    |23/44.86     23/42.75     29/45.88     21/47.53     | 
|POLY-3 PERCENT (g) |     68.8%        67.0%        59.0%        60.6%       |51.3%        53.8%        63.2%        44.2%        | 
|TERMINAL (d)       |     26/34 (77%)  25/36 (69%)  18/30 (60%)  22/38 (58%) |18/34 (53%)  19/33 (58%)  20/32 (63%)  19/40 (48%)  | 
|FIRST INCIDENCE    |     547          287          317          582         |573          649          582          600          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202N     P=0.460N     P=0.380N     P=0.204N    |P=0.081N     P=0.534      P=0.137      P=0.193N     | 
|POLY 3             |     P=0.260N     P=0.517N     P=0.222N     P=0.268N    |P=0.152N     P=0.490      P=0.168      P=0.316N     | 
|POLY 1.5           |     P=0.328N     P=0.545N     P=0.196N     P=0.330N    |P=0.193N     P=0.504      P=0.162      P=0.352N     | 
|POLY 6             |     P=0.184N     P=0.491N     P=0.246N     P=0.201N    |P=0.123N     P=0.488      P=0.178      P=0.285N     | 
|LOGISTIC REGRESSION|     P=0.305N     P=0.562      P=0.283N     P=0.304N    |P=0.142N     P=0.553      P=0.150      P=0.291N     | 
|COCH-ARM / FISHERS |     P=0.429N     P=0.582N     P=0.157N     P=0.419N    |P=0.289N     P=0.543      P=0.158      P=0.420N     | 
|ORDER RESTRICTED   |     P=0.279N     (e)          (e)          (e)         |P=0.180N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  30/50 (60%)  26/50 (52%)  25/50 (50%) |20/50 (40%)  25/49 (51%)  24/50 (48%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     23/49.12     30/48.54     26/46.83     25/49.21    |20/48.00     25/44.34     24/47.72     22/48.26     | 
|POLY-3 PERCENT (g) |     46.8%        61.8%        55.5%        50.8%       |41.7%        56.4%        50.3%        45.6%        | 
|TERMINAL (d)       |     9/34 (27%)   18/36 (50%)  11/30 (37%)  15/38 (40%) |9/34 (27%)   18/33 (55%)  11/32 (34%)  16/40 (40%)  | 
|FIRST INCIDENCE    |     385          270          400          382         |352          448          411          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.289N     P=0.216      P=0.227      P=0.541N    |P=0.247N     P=0.214      P=0.281      P=0.508N     | 
|POLY 3             |     P=0.418N     P=0.099      P=0.259      P=0.424     |P=0.437N     P=0.111      P=0.260      P=0.428      | 
|POLY 1.5           |     P=0.424N     P=0.100      P=0.281      P=0.423     |P=0.453N     P=0.132      P=0.265      P=0.426      | 
|POLY 6             |     P=0.418N     P=0.101      P=0.243      P=0.423     |P=0.423N     P=0.094      P=0.256      P=0.428      | 
|LOGISTIC REGRESSION|     P=0.515      P=0.108      P=0.519      P=0.244     |P=0.553      P=0.187      P=0.265      P=0.279      | 
|COCH-ARM / FISHERS |     P=0.447N     P=0.115      P=0.345      P=0.421     |P=0.494N     P=0.184      P=0.273      P=0.420      | 
|ORDER RESTRICTED   |     P=0.282      (e)          (e)          (e)         |P=0.295      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/15/04                           EXPERIMENT: 05201 TEST: 06                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                     FURFURYL ALCOHOL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     43/50 (86%)  44/50 (88%)  41/50 (82%)  39/50 (78%) |36/50 (72%)  37/49 (76%)  40/50 (80%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     43/49.70     44/49.48     41/48.76     39/50.00    |36/49.05     37/44.84     40/48.99     36/48.71     | 
|POLY-3 PERCENT (g) |     86.5%        88.9%        84.1%        78.0%       |73.4%        82.5%        81.7%        73.9%        | 
|TERMINAL (d)       |     28/34 (82%)  31/36 (86%)  23/30 (77%)  27/38 (71%) |22/34 (65%)  28/33 (85%)  24/32 (75%)  29/40 (73%)  | 
|FIRST INCIDENCE    |     385          270          317          382         |352          448          411          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.078N     P=0.514N     P=0.382      P=0.128N    |P=0.106N     P=0.433      P=0.263      P=0.244N     | 
|POLY 3             |     P=0.091N     P=0.476      P=0.477N     P=0.197N    |P=0.351N     P=0.202      P=0.229      P=0.569      | 
|POLY 1.5           |     P=0.102N     P=0.485      P=0.460N     P=0.207N    |P=0.369N     P=0.273      P=0.232      P=0.581      | 
|POLY 6             |     P=0.079N     P=0.471      P=0.483N     P=0.183N    |P=0.351N     P=0.145      P=0.228      P=0.544      | 
|LOGISTIC REGRESSION|     P=0.167N     P=0.503      P=0.338N     P=0.293N    |P=0.356N     P=0.410      P=0.241      P=0.549      | 
|COCH-ARM / FISHERS |     P=0.124N     P=0.500      P=0.393N     P=0.218N    |P=0.435N     P=0.433      P=0.241      P=0.588N     | 
|ORDER RESTRICTED   |     P=0.137N     (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.