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TDMS Study 96022-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 09:51:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                   FINAL#1 RATS CTRL. VS TREATED                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 002    80 NG  /10 UG                                                                 
                                       INCLUDE 003    240 NG /30 UG                                                                 
                                       INCLUDE 004    800 NG /100 UG                                                                
                                       INCLUDE 005    2400 NG/300 UG                                                                
                                       INCLUDE 006    4000 NG/500 UG                                                                
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 09:51:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      TEF EVALUATION (PCB MIXTURE;PCB 126/P                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Degeneration Cystic                                                                          
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
                                       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Blood Vessel: Aorta, Adventitia        Inflammation                                                                                 
Bone Marrow                            Atrophy                                                                                      
                                       Hyperplasia                                                                                  
Brain                                  Hemorrhage                                                                                   
Clitoral Gland                         Inflammation                                                                                 
Clitoral Gland: Duct                   Cyst                                                                                         
Esophagus: Muscularis                  Inflammation                                                                                 
Eye: Retina                            Atrophy                                                                                      
Harderian Gland                        Inflammation                                                                                 
Heart                                  Cardiomyopathy                                                                               
Heart: Coronary Artery                 Inflammation Chronic                                                                         
Heart: Epicardium                      Inflammation                                                                                 
Heart: Myocardium                      Hemorrhage                                                                                   
                                       Necrosis                                                                                     
Intestine Large, Cecum                 Edema                                                                                        
                                       Inflammation                                                                                 
Intestine Large, Colon                 Parasite Metazoan                                                                            
Intestine Large, Rectum                Parasite Metazoan                                                                            
Kidney                                 Calculus Micro Observation Only                                                              
                                       Inflammation                                                                                 
                                       Mineralization                                                                               
                                       Nephropathy                                                                                  
Kidney: Pelvis                         Inflammation                                                                                 
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Fatty Change Focal                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Metaplasia                                                                                   
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Cyst                                                                                         
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 09:51:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                       Fibrosis                                                                                     
                                       Hyperplasia                                                                                  
Liver: Centrilobular                   Degeneration                                                                                 
                                       Fibrosis                                                                                     
Liver: Hepatocyte                      Glandular Structures                                                                         
                                       Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Hemorrhage                                                                                   
                                       Infiltration Cellular Histiocyte                                                             
                                       Inflammation                                                                                 
                                       Metaplasia                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia Bronchiolar                                                                       
Lung: Serosa                           Fibrosis                                                                                     
Lymph Node, Mandibular                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                       Hyperplasia Lymphoid                                                                         
Lymph Node, Mesenteric                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Mediastinal                Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Lymph Node: Pancreatic                 Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                       Hyperplasia Lymphoid                                                                         
Lymph Node: Renal                      Hyperplasia                                                                                  
Mammary Gland                          Hyperplasia                                                                                  
                                       Inflammation Granulomatous                                                                   
Mesentery: Artery                      Inflammation Chronic                                                                         
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Inflammation                                                                                 
Nose: Glands                           Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Metaplasia                                                                                   
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Nose: Squamous Epithelium              Hyperplasia                                                                                  
Oral Mucosa: Gingival                  Hyperplasia                                                                                  
Ovary                                  Atrophy                                                                                      
                                       Cyst                                                                                         
Pancreas                               Edema                                                                                        
                                       Hemorrhage                                                                                   
                                       Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                       Vacuolization Cytoplasmic                                                                    
Pancreas: Artery                       Inflammation Chronic                                                                         
Pancreas: Duct                         Dilatation                                                                                   
Pituitary Gland                        Angiectasis                                                                                  
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Skin                                   Cyst Epithelial Inclusion                                                                    
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Spleen: Lymphoid Follicle              Atrophy                                                                                      
Spleen: Red Pulp                       Atrophy                                                                                      
Stomach, Forestomach                   Edema                                                                                        
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 09:51:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                       Hyperplasia                                                                                  
                                       Mineralization                                                                               
Stomach, Glandular                     Erosion                                                                                      
                                       Hemorrhage                                                                                   
                                       Mineralization                                                                               
Thymus                                 Atrophy                                                                                      
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Urinary Bladder                        Inflammation                                                                                 
Urinary Bladder: Transitional Epithelium                                                                                            
                                       Hyperplasia                                                                                  
Uterus                                 Adenomyosis                                                                                  
                                       Hemorrhage                                                                                   
                                       Inflammation                                                                                 
                                       Inflammation Chronic                                                                         
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P        
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        42/53 (79%)      35/51 (69%)      39/53 (74%)      25/53 (47%)      4/53 (8%)        6/65 (9%)       | 
|POLY-3 RATE (b)    |        42/48.03         35/42.89         39/47.84         25/42.51         4/25.64          6/14.36         | 
|POLY-3 PERCENT (g) |        87.4%            81.6%            81.5%            58.8%            15.6%            41.8%           | 
|TERMINAL (d)       |        26/27 (96%)      16/17 (94%)      21/24 (88%)      11/15 (73%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        482              70               63               390              450              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.515N         P=0.132          P=0.432          P=0.322N         P=0.342N         P=0.008 **      | 
|POLY 3             |        P<0.001N**       P=0.292N         P=0.281N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001N**       P=0.211N         P=0.273N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 6             |        P<0.001N**       P=0.401N         P=0.311N         P<0.001N**       P<0.001N**       P=0.249N        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.381N         P=0.447N         P=0.002N**       P<0.001N**       P=0.007N**      | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.156N         P=0.324N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        1/51 (2%)        0/53 (0%)        15/53 (28%)      44/53 (83%)      40/65 (62%)     | 
|POLY-3 RATE (b)    |        2/42.18          1/33.36          0/37.79          15/39.73         44/45.82         40/41.82        | 
|POLY-3 PERCENT (g) |        4.7%             3.0%             0.0%             37.8%            96.0%            95.7%           | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        0/24 (0%)        5/15 (33%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        649              443              ---              534              349              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.614N         P=0.273N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.581N         P=0.262N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.560N         P=0.253N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.603N         P=0.272N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.494N         P=0.260N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.515N         P=0.248N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        12/53 (23%)      12/51 (24%)      13/53 (25%)      11/53 (21%)      6/53 (11%)       2/65 (3%)       | 
|POLY-3 RATE (b)    |        12/43.80         12/34.17         13/40.71         11/40.47         6/27.37          2/10.85         | 
|POLY-3 PERCENT (g) |        27.4%            35.1%            31.9%            27.2%            21.9%            18.4%           | 
|TERMINAL (d)       |        6/27 (22%)       7/17 (41%)       7/24 (29%)       0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        482              541              408              534              482              336             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.017 *        P=0.189          P=0.368          P=0.359          P=0.094          P=0.152         | 
|POLY 3             |        P=0.186N         P=0.313          P=0.413          P=0.589N         P=0.409N         P=0.442N        | 
|POLY 1.5           |        P=0.031N*        P=0.386          P=0.444          P=0.566N         P=0.240N         P=0.116N        | 
|POLY 6             |        P=0.467N         P=0.249          P=0.382          P=0.580          P=0.547          P=0.479         | 
|LOGISTIC REGRESSION|        P=0.044N*        P=0.312          P=0.440          P=0.551N         P=0.255N         P=0.396N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.549          P=0.500          P=0.500N         P=0.098N         P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.540N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/53 (25%)      7/51 (14%)       13/53 (25%)      12/53 (23%)      10/53 (19%)      5/65 (8%)       | 
|POLY-3 RATE (b)    |        13/44.54         7/34.51          13/40.27         12/39.26         10/28.88         5/13.17         | 
|POLY-3 PERCENT (g) |        29.2%            20.3%            32.3%            30.6%            34.6%            38.0%           | 
|TERMINAL (d)       |        5/27 (19%)       3/17 (18%)       9/24 (38%)       5/15 (33%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        362              436              455              552              267              321             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.391N         P=0.444          P=0.295          P=0.005 **       P=0.004 **      | 
|POLY 3             |        P=0.222          P=0.261N         P=0.470          P=0.541          P=0.409          P=0.423         | 
|POLY 1.5           |        P=0.490N         P=0.210N         P=0.515          P=0.587          P=0.578N         P=0.368N        | 
|POLY 6             |        P=0.048 *        P=0.318N         P=0.419          P=0.470          P=0.167          P=0.195         | 
|LOGISTIC REGRESSION|        P=0.531N         P=0.178N         P=0.539          P=0.579N         P=0.452N         P=0.532N        | 
|COCH-ARM / FISHERS |        P=0.014N*        P=0.125N         P=0.589N         P=0.500N         P=0.319N         P=0.011N*       | 
|ORDER RESTRICTED   |        P=0.487          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        45/53 (85%)      40/51 (78%)      47/53 (89%)      44/53 (83%)      45/53 (85%)      27/65 (42%)     | 
|POLY-3 RATE (b)    |        45/48.89         40/44.19         47/48.81         44/47.04         45/46.85         27/31.15        | 
|POLY-3 PERCENT (g) |        92.1%            90.5%            96.3%            93.5%            96.1%            86.7%           | 
|TERMINAL (d)       |        26/27 (96%)      15/17 (88%)      24/24 (100%)     14/15 (93%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              328              399              390              337              174             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.067          P=0.148          P=0.017 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.480N         P=0.549N         P=0.278          P=0.555          P=0.305          P=0.303N        | 
|POLY 1.5           |        P=0.011N*        P=0.522N         P=0.290          P=0.541          P=0.393          P=0.006N**      | 
|POLY 6             |        P=0.219          P=0.495N         P=0.294          P=0.604          P=0.268          P=0.635         | 
|LOGISTIC REGRESSION|        P=0.308          P=0.480          P=0.167          P=0.422          P=0.057          P=0.527         | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.274N         P=0.388          P=0.500N         P=0.607N         P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.129N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/51 (0%)        2/53 (4%)        4/53 (8%)        1/53 (2%)        4/65 (6%)       | 
|POLY-3 RATE (b)    |        1/42.24          0/32.58          2/39.10          4/38.53          1/24.86          4/13.13         | 
|POLY-3 PERCENT (g) |        2.4%             0.0%             5.1%             10.4%            4.0%             30.5%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        628              ---              426              548              313              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.571N         P=0.457          P=0.139          P=0.649          P=0.077         | 
|POLY 3             |        P=0.037 *        P=0.551N         P=0.473          P=0.151          P=0.630          P=0.028 *       | 
|POLY 1.5           |        P=0.062          P=0.537N         P=0.483          P=0.159          P=0.693          P=0.063         | 
|POLY 6             |        P=0.014 *        P=0.566N         P=0.463          P=0.137          P=0.533          P=0.016 *       | 
|LOGISTIC REGRESSION|        P=0.486N         P=0.512N         P=0.571          P=0.202          P=0.607N         P=0.627N        | 
|COCH-ARM / FISHERS |        P=0.172          P=0.510N         P=0.500          P=0.181          P=0.752N         P=0.252         | 
|ORDER RESTRICTED   |        P=0.005 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/53 (26%)      16/51 (31%)      13/53 (25%)      24/53 (45%)      27/53 (51%)      12/65 (18%)     | 
|POLY-3 RATE (b)    |        14/44.09         16/36.76         13/41.07         24/41.43         27/36.88         12/18.81        | 
|POLY-3 PERCENT (g) |        31.8%            43.5%            31.7%            57.9%            73.2%            63.8%           | 
|TERMINAL (d)       |        6/27 (22%)       7/17 (41%)       7/24 (29%)       10/15 (67%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        564              70               443              539              313              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.092          P=0.516          P=0.002 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.191          P=0.589N         P=0.010 *        P<0.001 **       P=0.034 *       | 
|POLY 1.5           |        P=0.003 **       P=0.243          P=0.555N         P=0.014 *        P<0.001 **       P=0.223         | 
|POLY 6             |        P<0.001 **       P=0.149          P=0.560          P=0.005 **       P<0.001 **       P=0.006 **      | 
|LOGISTIC REGRESSION|        P=0.007 **       P=0.246          P=0.560N         P=0.011 *        P<0.001 **       P=0.266         | 
|COCH-ARM / FISHERS |        P=0.294N         P=0.366          P=0.500N         P=0.034 *        P=0.008 **       P=0.208N        | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/53 (25%)      4/51 (8%)        9/53 (17%)       12/53 (23%)      2/53 (4%)        0/64 (0%)       | 
|POLY-3 RATE (b)    |        13/42.77         4/32.97          9/38.63          12/38.98         2/24.72          0/9.22          | 
|POLY-3 PERCENT (g) |        30.4%            12.1%            23.3%            30.8%            8.1%             0.0%            | 
|TERMINAL (d)       |        10/27 (37%)      3/17 (18%)       7/24 (29%)       4/15 (27%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        628              616              567              552              525              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.123          P=0.112N         P=0.353N         P=0.220          P=0.363          P=0.999N        | 
|POLY 3             |        P=0.079N         P=0.051N         P=0.317N         P=0.581          P=0.039N*        P=0.166N        | 
|POLY 1.5           |        P=0.007N**       P=0.038N*        P=0.285N         P=0.576N         P=0.011N*        P=0.015N*       | 
|POLY 6             |        P=0.383N         P=0.070N         P=0.353N         P=0.532          P=0.164N         P=0.440N        | 
|LOGISTIC REGRESSION|        P=0.187N         P=0.072N         P=0.358N         P=0.491          P=0.231N         P=0.612N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.020N*        P=0.237N         P=0.500N         P=0.002N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.186N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta, Adventitia                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/52 (0%)        0/53 (0%)        1/53 (2%)        2/66 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.04          0/36.73          1/24.55          2/11.08         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             4.1%             18.1%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              530              294             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.409          P=0.123         | 
|POLY 3             |        P=0.022 *        (e)              (e)              (e)              P=0.400          P=0.095         | 
|POLY 1.5           |        P=0.014 *        (e)              (e)              (e)              P=0.443          P=0.136         | 
|POLY 6             |        P=0.038 *        (e)              (e)              (e)              P=0.343          P=0.077         | 
|LOGISTIC REGRESSION|        P=0.093          (e)              (e)              (e)              P=0.589          P=0.609         | 
|COCH-ARM / FISHERS |        P=0.020 *        (e)              (e)              (e)              P=0.500          P=0.306         | 
|ORDER RESTRICTED   |        P=0.004 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        12/66 (18%)     | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          2/25.71          12/20.74        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.8%             57.9%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              313              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.231          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.149          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.184          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.110          P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.495          P=0.387         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.248          P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        37/53 (70%)      41/51 (80%)      36/53 (68%)      48/53 (91%)      47/53 (89%)      49/66 (74%)     | 
|POLY-3 RATE (b)    |        37/51.61         41/49.07         36/50.24         48/52.21         47/48.90         49/50.11        | 
|POLY-3 PERCENT (g) |        71.7%            83.6%            71.7%            91.9%            96.1%            97.8%           | 
|TERMINAL (d)       |        14/27 (52%)      10/17 (59%)      12/24 (50%)      13/15 (87%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              70               63               41               166              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.022 *        P=0.371          P=0.002 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.112          P=0.586N         P=0.005 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.121          P=0.560N         P=0.006 **       P<0.001 **       P=0.002 **      | 
|POLY 6             |        P<0.001 **       P=0.113          P=0.576          P=0.005 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.503          P=0.338          P=0.360N         P=0.021 *        P=0.069          P=0.298         | 
|COCH-ARM / FISHERS |        P=0.328          P=0.154          P=0.500N         P=0.007 **       P=0.015 *        P=0.369         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        1/53 (2%)        4/53 (8%)        5/53 (9%)        14/66 (21%)     | 
|POLY-3 RATE (b)    |        0/41.89          1/33.49          1/37.79          4/38.75          5/28.06          14/22.64        | 
|POLY-3 PERCENT (g) |        0.0%             3.0%             2.7%             10.3%            17.8%            61.8%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        1/24 (4%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              328              726 (T)          78               313              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.488          P=0.477          P=0.047 *        P=0.026 *        P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.456          P=0.479          P=0.050          P=0.009 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.467          P=0.487          P=0.054          P=0.016 *        P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.444          P=0.472          P=0.044 *        P=0.004 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.044 *        P=0.724          P=0.477          P=0.103          P=0.160          P=0.402         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.490          P=0.500          P=0.059          P=0.028 *        P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        2/53 (4%)        1/53 (2%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          2/38.16          1/24.47          0/9.33          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.2%             4.1%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              78               565              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.360          (e)              (e)              P=0.220          P=0.379          (e)             | 
|POLY 3             |        P=0.121          (e)              (e)              P=0.216          P=0.399          (e)             | 
|POLY 1.5           |        P=0.294          (e)              (e)              P=0.225          P=0.443          (e)             | 
|POLY 6             |        P=0.032 *        (e)              (e)              P=0.203          P=0.343          (e)             | 
|LOGISTIC REGRESSION|        P=0.319N         (e)              (e)              P=0.416          P=0.546          (e)             | 
|COCH-ARM / FISHERS |        P=0.603N         (e)              (e)              P=0.248          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.534          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        2/53 (4%)        1/53 (2%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          2/38.16          1/24.47          0/9.33          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.2%             4.1%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              78               565              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.360          (e)              (e)              P=0.220          P=0.379          (e)             | 
|POLY 3             |        P=0.121          (e)              (e)              P=0.216          P=0.399          (e)             | 
|POLY 1.5           |        P=0.294          (e)              (e)              P=0.225          P=0.443          (e)             | 
|POLY 6             |        P=0.032 *        (e)              (e)              P=0.203          P=0.343          (e)             | 
|LOGISTIC REGRESSION|        P=0.319N         (e)              (e)              P=0.416          P=0.546          (e)             | 
|COCH-ARM / FISHERS |        P=0.603N         (e)              (e)              P=0.248          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.534          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        49/53 (92%)      44/51 (86%)      46/51 (90%)      34/52 (65%)      21/52 (40%)      31/66 (47%)     | 
|POLY-3 RATE (b)    |        49/52.29         44/48.11         46/49.70         34/45.57         21/35.74         31/35.89        | 
|POLY-3 PERCENT (g) |        93.7%            91.5%            92.6%            74.6%            58.8%            86.4%           | 
|TERMINAL (d)       |        24/27 (89%)      16/17 (94%)      22/24 (92%)      10/15 (67%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              70               63               390              267              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.078          P=0.403          P=0.534N         P=0.014 *        P<0.001 **      | 
|POLY 3             |        P<0.001N**       P=0.479N         P=0.569N         P=0.005N**       P<0.001N**       P=0.160N        | 
|POLY 1.5           |        P<0.001N**       P=0.390N         P=0.518N         P=0.002N**       P<0.001N**       P<0.001N**      | 
|POLY 6             |        P=0.083N         P=0.570N         P=0.657N         P=0.015N*        P<0.001N**       P=0.532         | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.272N         P=0.454N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.241N         P=0.475N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/53 (75%)      41/51 (80%)      43/51 (84%)      45/52 (87%)      48/52 (92%)      61/66 (92%)     | 
|POLY-3 RATE (b)    |        40/50.23         41/46.05         43/48.26         45/49.78         48/49.06         61/61.31        | 
|POLY-3 PERCENT (g) |        79.6%            89.0%            89.1%            90.4%            97.9%            99.5%           | 
|TERMINAL (d)       |        20/27 (74%)      17/17 (100%)     21/24 (88%)      13/15 (87%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        313              78               399              41               166              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.019 *        P=0.156          P=0.008 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.145          P=0.144          P=0.096          P=0.002 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.210          P=0.147          P=0.110          P=0.004 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.079          P=0.139          P=0.073          P=0.002 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.268          P=0.158          P=0.117          P=0.010 *        P=0.017 *       | 
|COCH-ARM / FISHERS |        P=0.004 **       P=0.357          P=0.190          P=0.116          P=0.018 *        P=0.010 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        0/51 (0%)        2/53 (4%)        3/53 (6%)        3/53 (6%)        2/66 (3%)       | 
|POLY-3 RATE (b)    |        3/42.85          0/32.58          2/38.52          3/37.73          3/26.07          2/10.61         | 
|POLY-3 PERCENT (g) |        7.0%             0.0%             5.2%             8.0%             11.5%            18.9%           | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        1/24 (4%)        2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              ---              471              78               373              254             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.005 **       P=0.198N         P=0.562N         P=0.503          P=0.291          P=0.066         | 
|POLY 3             |        P=0.094          P=0.175N         P=0.549N         P=0.603          P=0.424          P=0.347         | 
|POLY 1.5           |        P=0.186          P=0.157N         P=0.530N         P=0.628          P=0.532          P=0.556         | 
|POLY 6             |        P=0.049 *        P=0.195N         P=0.568N         P=0.561          P=0.285          P=0.234         | 
|LOGISTIC REGRESSION|        P=0.469N         P=0.125N         P=0.477N         P=0.592N         P=0.510N         P=0.783         | 
|COCH-ARM / FISHERS |        P=0.538          P=0.129N         P=0.500N         P=0.661N         P=0.661N         P=0.397N        | 
|ORDER RESTRICTED   |        P=0.245          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        3/51 (6%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        1/42.21          3/33.49          0/37.79          0/36.73          0/23.94          0/9.33          | 
|POLY-3 PERCENT (g) |        2.4%             9.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        2/17 (12%)       0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        639              328              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.267N         P=0.199          P=0.541N         P=0.541N         P=0.713N         P=1.000N        | 
|POLY 3             |        P=0.164N         P=0.227          P=0.522N         P=0.528N         P=0.605N         P=0.697N        | 
|POLY 1.5           |        P=0.142N         P=0.247          P=0.514N         P=0.518N         P=0.559N         P=0.626N        | 
|POLY 6             |        P=0.162N         P=0.206          P=0.531N         P=0.544N         P=0.664N         P=0.735N        | 
|LOGISTIC REGRESSION|        P=0.064N         P=0.306          P=0.499N         P=0.502N         P=0.593N         P=0.905N        | 
|COCH-ARM / FISHERS |        P=0.074N         P=0.294          P=0.500N         P=0.500N         P=0.500N         P=0.445N        | 
|ORDER RESTRICTED   |        P=0.499N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        3/51 (6%)        0/53 (0%)        1/53 (2%)        0/53 (0%)        1/66 (2%)       | 
|POLY-3 RATE (b)    |        1/42.21          3/32.89          0/37.79          1/36.73          0/23.94          1/9.73          | 
|POLY-3 PERCENT (g) |        2.4%             9.1%             0.0%             2.7%             0.0%             10.3%           | 
|TERMINAL (d)       |        0/27 (0%)        2/17 (12%)       0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        639              642              ---              726 (T)          ---              611             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.054          P=0.180          P=0.541N         P=0.671          P=0.713N         P=0.016 *       | 
|POLY 3             |        P=0.438N         P=0.222          P=0.522N         P=0.729          P=0.605N         P=0.442         | 
|POLY 1.5           |        P=0.414N         P=0.243          P=0.514N         P=0.741          P=0.559N         P=0.580         | 
|POLY 6             |        P=0.443N         P=0.202          P=0.531N         P=0.709          P=0.664N         P=0.358         | 
|LOGISTIC REGRESSION|        P=0.371          P=0.216          P=0.499N         P=0.734          P=0.593N         P=0.457         | 
|COCH-ARM / FISHERS |        P=0.263N         P=0.294          P=0.500N         P=0.752N         P=0.500N         P=0.694N        | 
|ORDER RESTRICTED   |        P=0.405          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        24/53 (45%)      7/51 (14%)       20/53 (38%)      13/53 (25%)      7/53 (13%)       9/66 (14%)      | 
|POLY-3 RATE (b)    |        24/45.26         7/34.66          20/40.69         13/38.18         7/27.04          9/16.65         | 
|POLY-3 PERCENT (g) |        53.0%            20.2%            49.2%            34.1%            25.9%            54.1%           | 
|TERMINAL (d)       |        15/27 (56%)      1/17 (6%)        13/24 (54%)      7/15 (47%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        313              541              455              567              523              217             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.023N*        P=0.479N         P=0.356N         P=0.082          P<0.001 **      | 
|POLY 3             |        P=0.216N         P=0.002N**       P=0.441N         P=0.056N         P=0.020N*        P=0.571         | 
|POLY 1.5           |        P=0.045N*        P<0.001N**       P=0.378N         P=0.039N*        P=0.003N**       P=0.111N        | 
|POLY 6             |        P=0.489          P=0.003N**       P=0.510N         P=0.100N         P=0.155N         P=0.194         | 
|LOGISTIC REGRESSION|        P=0.484N         P=0.002N**       P=0.415N         P=0.054N         P=0.030N*        P=0.329N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001N**       P=0.277N         P=0.020N*        P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.266N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        20/53 (38%)      13/51 (25%)      17/53 (32%)      34/53 (64%)      14/53 (26%)      19/65 (29%)     | 
|POLY-3 RATE (b)    |        20/45.03         13/36.13         17/42.28         34/44.99         14/30.44         19/24.56        | 
|POLY-3 PERCENT (g) |        44.4%            36.0%            40.2%            75.6%            46.0%            77.4%           | 
|TERMINAL (d)       |        11/27 (41%)      3/17 (18%)       7/24 (29%)       10/15 (67%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              525              408              537              447              237             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.531N         P=0.526N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.006 **       P=0.292N         P=0.427N         P<0.001 **       P=0.540          P=0.009 **      | 
|POLY 1.5           |        P=0.124          P=0.236N         P=0.395N         P<0.001 **       P=0.402N         P=0.125         | 
|POLY 6             |        P<0.001 **       P=0.335N         P=0.456N         P<0.001 **       P=0.244          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.038 *        P=0.266N         P=0.406N         P<0.001 **       P=0.566          P=0.117         | 
|COCH-ARM / FISHERS |        P=0.108N         P=0.129N         P=0.342N         P=0.006 **       P=0.149N         P=0.217N        | 
|ORDER RESTRICTED   |        P=0.003 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Coronary Artery                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        1/51 (2%)        0/53 (0%)        7/53 (13%)       10/53 (19%)      9/65 (14%)      | 
|POLY-3 RATE (b)    |        1/41.89          1/32.58          0/37.79          7/37.65          10/29.16         9/16.16         | 
|POLY-3 PERCENT (g) |        2.4%             3.1%             0.0%             18.6%            34.3%            55.7%           | 
|TERMINAL (d)       |        1/27 (4%)        1/17 (6%)        0/24 (0%)        3/15 (20%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          726 (T)          ---              567              450              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.656          P=0.523N         P=0.006 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.702          P=0.521N         P=0.019 *        P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.719          P=0.513N         P=0.023 *        P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.685          P=0.528N         P=0.015 *        P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.656          (e)              P=0.015 *        P=0.005 **       P=0.007 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.743          P=0.500N         P=0.030 *        P=0.004 **       P=0.019 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Epicardium                                                                                                                | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        1/51 (2%)        0/53 (0%)        6/53 (11%)       13/53 (25%)      6/65 (9%)       | 
|POLY-3 RATE (b)    |        1/42.60          1/33.49          0/37.79          6/38.00          13/30.80         6/13.78         | 
|POLY-3 PERCENT (g) |        2.4%             3.0%             0.0%             15.8%            42.2%            43.5%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        482              328              ---              619              313              362             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.732          P=0.525N         P=0.028 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.705          P=0.524N         P=0.038 *        P<0.001 **       P=0.003 **      | 
|POLY 1.5           |        P<0.001 **       P=0.721          P=0.515N         P=0.044 *        P<0.001 **       P=0.009 **      | 
|POLY 6             |        P<0.001 **       P=0.688          P=0.533N         P=0.032 *        P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.608N         P=0.431N         P=0.054          P=0.003 **       P=0.087         | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.743          P=0.500N         P=0.056          P<0.001 **       P=0.096         | 
|ORDER RESTRICTED   |        P=0.002 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        3/65 (5%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          0/23.94          3/12.08         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             24.8%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              267             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.084         | 
|POLY 3             |        P=0.029 *        (e)              (e)              (e)              (e)              P=0.030 *       | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.051         | 
|POLY 6             |        P=0.063          (e)              (e)              (e)              (e)              P=0.022 *       | 
|LOGISTIC REGRESSION|        P=0.074          (e)              (e)              (e)              (e)              P=0.655         | 
|COCH-ARM / FISHERS |        P=0.004 **       (e)              (e)              (e)              (e)              P=0.164         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          0/23.94          2/11.19         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             17.9%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012 *        (e)              (e)              (e)              (e)              P=0.229         | 
|POLY 3             |        P=0.101          (e)              (e)              (e)              (e)              P=0.094         | 
|POLY 1.5           |        P=0.042 *        (e)              (e)              (e)              (e)              P=0.135         | 
|POLY 6             |        P=0.193          (e)              (e)              (e)              (e)              P=0.076         | 
|LOGISTIC REGRESSION|        P=0.151          (e)              (e)              (e)              (e)              P=0.890         | 
|COCH-ARM / FISHERS |        P=0.019 *        (e)              (e)              (e)              (e)              P=0.301         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/52 (0%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          0/23.71          2/11.19         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             17.9%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              254             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012 *        (e)              (e)              (e)              (e)              P=0.229         | 
|POLY 3             |        P=0.103          (e)              (e)              (e)              (e)              P=0.094         | 
|POLY 1.5           |        P=0.042 *        (e)              (e)              (e)              (e)              P=0.135         | 
|POLY 6             |        P=0.194          (e)              (e)              (e)              (e)              P=0.076         | 
|LOGISTIC REGRESSION|        P=0.151          (e)              (e)              (e)              (e)              P=0.865         | 
|COCH-ARM / FISHERS |        P=0.019 *        (e)              (e)              (e)              (e)              P=0.301         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/52 (0%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          0/23.71          2/11.20         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             17.9%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.014 *        (e)              (e)              (e)              (e)              P=0.243         | 
|POLY 3             |        P=0.102          (e)              (e)              (e)              (e)              P=0.094         | 
|POLY 1.5           |        P=0.042 *        (e)              (e)              (e)              (e)              P=0.135         | 
|POLY 6             |        P=0.194          (e)              (e)              (e)              (e)              P=0.076         | 
|LOGISTIC REGRESSION|        P=0.151          (e)              (e)              (e)              (e)              P=0.887         | 
|COCH-ARM / FISHERS |        P=0.019 *        (e)              (e)              (e)              (e)              P=0.301         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum: Artery                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        2/53 (4%)        0/52 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          2/37.26          0/23.71          0/9.28          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.4%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              567              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.505          (e)              (e)              P=0.165          (e)              (e)             | 
|POLY 3             |        P=0.448          (e)              (e)              P=0.211          (e)              (e)             | 
|POLY 1.5           |        P=0.641          (e)              (e)              P=0.220          (e)              (e)             | 
|POLY 6             |        P=0.182          (e)              (e)              P=0.198          (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.730N         (e)              (e)              P=0.229          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.442N         (e)              (e)              P=0.248          (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.589          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        1/51 (2%)        0/53 (0%)        0/53 (0%)        0/52 (0%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        2/41.97          1/33.04          0/37.79          0/36.73          0/23.71          2/11.13         | 
|POLY-3 PERCENT (g) |        4.8%             3.0%             0.0%             0.0%             0.0%             18.0%           | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        707              594              ---              ---              ---              236             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.038 *        P=0.635N         P=0.269N         P=0.356N         P=0.962N         P=0.175         | 
|POLY 3             |        P=0.590          P=0.582N         P=0.261N         P=0.268N         P=0.379N         P=0.283         | 
|POLY 1.5           |        P=0.483          P=0.561N         P=0.252N         P=0.256N         P=0.313N         P=0.444         | 
|POLY 6             |        P=0.505N         P=0.603N         P=0.270N         P=0.287N         P=0.480N         P=0.197         | 
|LOGISTIC REGRESSION|        P=0.537          P=0.580N         P=0.269N         P=0.317N         P=0.802N         P=0.807N        | 
|COCH-ARM / FISHERS |        P=0.443          P=0.515N         P=0.248N         P=0.248N         P=0.252N         P=0.610N        | 
|ORDER RESTRICTED   |        P=0.036 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/52 (6%)        2/51 (4%)        2/53 (4%)        2/53 (4%)        1/52 (2%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        3/41.84          2/33.62          2/38.04          2/37.00          1/24.57          0/9.33          | 
|POLY-3 PERCENT (g) |        7.2%             6.0%             5.3%             5.4%             4.1%             0.0%            | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        1/24 (4%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        567              541              659              687              373              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.618          P=0.657N         P=0.559N         P=0.667N         P=0.702          P=0.987N        | 
|POLY 3             |        P=0.357N         P=0.599N         P=0.543N         P=0.556N         P=0.508N         P=0.482N        | 
|POLY 1.5           |        P=0.205N         P=0.571N         P=0.524N         P=0.532N         P=0.413N         P=0.300N        | 
|POLY 6             |        P=0.504N         P=0.625N         P=0.564N         P=0.593N         P=0.639N         P=0.604N        | 
|LOGISTIC REGRESSION|        P=0.109N         P=0.516N         P=0.529N         P=0.546N         P=0.273N         P=0.613N        | 
|COCH-ARM / FISHERS |        P=0.043N*        P=0.509N         P=0.491N         P=0.491N         P=0.309N         P=0.083N        | 
|ORDER RESTRICTED   |        P=0.548N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum: Artery                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        1/51 (2%)        1/53 (2%)        3/53 (6%)        1/52 (2%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        0/41.24          1/32.58          1/37.79          3/37.69          1/24.26          0/9.33          | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             2.7%             8.0%             4.1%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        1/24 (4%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          726 (T)          567              555              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.109          P=0.408          P=0.477          P=0.079          P=0.386          (e)             | 
|POLY 3             |        P=0.279          P=0.453          P=0.483          P=0.103          P=0.400          (e)             | 
|POLY 1.5           |        P=0.528          P=0.467          P=0.491          P=0.109          P=0.444          (e)             | 
|POLY 6             |        P=0.089          P=0.439          P=0.474          P=0.093          P=0.344          (e)             | 
|LOGISTIC REGRESSION|        P=0.569          P=0.408          P=0.477          P=0.122          P=0.560          (e)             | 
|COCH-ARM / FISHERS |        P=0.270N         P=0.495          P=0.505          P=0.125          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.547          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/53 (11%)       6/51 (12%)       6/53 (11%)       0/53 (0%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        6/42.65          6/32.84          6/39.15          0/36.73          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        14.1%            18.3%            15.3%            0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        4/27 (15%)       5/17 (29%)       3/24 (13%)       0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        586              659              443              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.066N         P=0.313          P=0.530          P=0.055N         P=0.508N         P=0.985N        | 
|POLY 3             |        P=0.005N**       P=0.430          P=0.560          P=0.024N*        P=0.082N         P=0.343N        | 
|POLY 1.5           |        P=0.002N**       P=0.484          P=0.583          P=0.021N*        P=0.040N*        P=0.128N        | 
|POLY 6             |        P=0.008N**       P=0.375          P=0.538          P=0.032N*        P=0.193N         P=0.532N        | 
|LOGISTIC REGRESSION|        P=0.008N**       P=0.382          P=0.575          P=0.027N*        P=0.129N         P=0.561N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.592          P=0.620N         P=0.013N*        P=0.013N*        P=0.007N**      | 
|ORDER RESTRICTED   |        P=0.334N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/51 (4%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          2/33.36          0/37.79          0/36.73          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        0.0%             6.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              443              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.443N         P=0.173          (e)              (e)              (e)              (e)             | 
|POLY 3             |        P=0.365N         P=0.190          (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.329N         P=0.201          (e)              (e)              (e)              (e)             | 
|POLY 6             |        P=0.362N         P=0.178          (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.189N         P=0.248          (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.208N         P=0.238          (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.607N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        1/65 (2%)       | 
|POLY-3 RATE (b)    |        2/41.89          0/32.58          0/37.79          0/36.73          0/23.94          1/10.26         | 
|POLY-3 PERCENT (g) |        4.8%             0.0%             0.0%             0.0%             0.0%             9.8%            | 
|TERMINAL (d)       |        2/27 (7%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          ---              ---              ---              ---              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.192          P=0.344N         P=0.264N         P=0.374N         P=1.000N         P=0.534         | 
|POLY 3             |        P=0.532N         P=0.296N         P=0.260N         P=0.267N         P=0.377N         P=0.535         | 
|POLY 1.5           |        P=0.618N         P=0.280N         P=0.252N         P=0.256N         P=0.310N         P=0.705         | 
|POLY 6             |        P=0.383N         P=0.314N         P=0.269N         P=0.286N         P=0.478N         P=0.417         | 
|LOGISTIC REGRESSION|        P=0.633N         (e)              (e)              (e)              (e)              P=0.732N        | 
|COCH-ARM / FISHERS |        P=0.607N         P=0.257N         P=0.248N         P=0.248N         P=0.248N         P=0.423N        | 
|ORDER RESTRICTED   |        P=0.191          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        4/53 (8%)        3/53 (6%)        0/53 (0%)        1/65 (2%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/32.58          4/38.07          3/37.44          0/23.94          1/10.26         | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             10.5%            8.0%             0.0%             9.8%            | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        3/24 (13%)       1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          651              594              ---              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.087          P=0.408          P=0.049 *        P=0.077          (e)              P=0.534         | 
|POLY 3             |        P=0.568          P=0.450          P=0.048 *        P=0.099          (e)              P=0.307         | 
|POLY 1.5           |        P=0.452N         P=0.464          P=0.053          P=0.106          (e)              P=0.378         | 
|POLY 6             |        P=0.335          P=0.437          P=0.044 *        P=0.090          (e)              P=0.268         | 
|LOGISTIC REGRESSION|        P=0.569N         P=0.408          P=0.045 *        P=0.107          (e)              P=0.996         | 
|COCH-ARM / FISHERS |        P=0.189N         P=0.490          P=0.059          P=0.121          (e)              P=0.551         | 
|ORDER RESTRICTED   |        P=0.373          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        46/53 (87%)      34/51 (67%)      38/53 (72%)      44/53 (83%)      34/53 (64%)      37/65 (57%)     | 
|POLY-3 RATE (b)    |        46/51.13         34/44.52         38/48.48         44/50.44         34/44.31         37/39.76        | 
|POLY-3 PERCENT (g) |        90.0%            76.4%            78.4%            87.2%            76.7%            93.1%           | 
|TERMINAL (d)       |        23/27 (85%)      10/17 (59%)      19/24 (79%)      14/15 (93%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        313              275              63               41               166              217             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.424          P=0.402N         P=0.048 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.282          P=0.055N         P=0.080N         P=0.449N         P=0.046N*        P=0.434         | 
|POLY 1.5           |        P=0.329N         P=0.037N*        P=0.057N         P=0.398N         P=0.015N*        P=0.219N        | 
|POLY 6             |        P=0.059          P=0.076N         P=0.124N         P=0.557N         P=0.206N         P=0.127         | 
|LOGISTIC REGRESSION|        P=0.048N*        P=0.033N*        P=0.055N         P=0.397N         P=0.004N**       P=0.551N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.013N*        P=0.046N*        P=0.393N         P=0.006N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.093          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        41/53 (77%)      37/51 (73%)      37/53 (70%)      48/53 (91%)      50/53 (94%)      43/65 (66%)     | 
|POLY-3 RATE (b)    |        41/49.70         37/43.32         37/46.04         48/49.44         50/50.38         43/44.50        | 
|POLY-3 PERCENT (g) |        82.5%            85.4%            80.4%            97.1%            99.3%            96.6%           | 
|TERMINAL (d)       |        24/27 (89%)      14/17 (82%)      21/24 (88%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              328              63               41               267              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.077          P=0.512          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.457          P=0.498N         P=0.008 **       P<0.001 **       P=0.013 *       | 
|POLY 1.5           |        P=0.003 **       P=0.520          P=0.394N         P=0.013 *        P=0.002 **       P=0.144         | 
|POLY 6             |        P<0.001 **       P=0.466          P=0.593N         P=0.008 **       P=0.003 **       P=0.006 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.552          P=0.326N         P=0.025 *        P=0.003 **       P=0.133         | 
|COCH-ARM / FISHERS |        P=0.321N         P=0.367N         P=0.255N         P=0.055          P=0.012 *        P=0.128N        | 
|ORDER RESTRICTED   |        P=0.002 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        6/51 (12%)       1/53 (2%)        6/53 (11%)       0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        4/42.25          6/34.63          1/37.79          6/38.27          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        9.5%             17.3%            2.7%             15.7%            0.0%             0.0%            | 
|TERMINAL (d)       |        2/27 (7%)        0/17 (0%)        1/24 (4%)        2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        672              525              726 (T)          567              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.452N         P=0.181          P=0.228N         P=0.176          P=0.724N         P=1.000         | 
|POLY 3             |        P=0.154N         P=0.250          P=0.213N         P=0.306          P=0.171N         P=0.426N        | 
|POLY 1.5           |        P=0.048N*        P=0.275          P=0.200N         P=0.327          P=0.110N         P=0.226N        | 
|POLY 6             |        P=0.412N         P=0.231          P=0.228N         P=0.276          P=0.294N         P=0.574N        | 
|LOGISTIC REGRESSION|        P=0.041N*        P=0.275          P=0.223N         P=0.306          P=0.356N         P=0.876N        | 
|COCH-ARM / FISHERS |        P=0.003N**       P=0.346          P=0.181N         P=0.371          P=0.059N         P=0.038N*       | 
|ORDER RESTRICTED   |        P=0.415N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        2/42.10          0/32.58          0/37.79          0/36.73          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        4.8%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        672              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.608N         P=0.339N         P=0.275N         P=0.348N         P=0.804N         P=1.000N        | 
|POLY 3             |        P=0.234N         P=0.298N         P=0.262N         P=0.268N         P=0.378N         P=0.564N        | 
|POLY 1.5           |        P=0.239N         P=0.280N         P=0.252N         P=0.257N         P=0.310N         P=0.424N        | 
|POLY 6             |        P=0.189N         P=0.317N         P=0.272N         P=0.288N         P=0.480N         P=0.651N        | 
|LOGISTIC REGRESSION|        P=0.441N         P=0.307N         P=0.266N         P=0.284N         P=0.587N         P=0.966N        | 
|COCH-ARM / FISHERS |        P=0.188N         P=0.257N         P=0.248N         P=0.248N         P=0.248N         P=0.200N        | 
|ORDER RESTRICTED   |        P=0.411N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        6/51 (12%)       6/53 (11%)       16/53 (30%)      1/53 (2%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        4/42.25          6/34.63          6/38.96          16/40.69         1/24.51          0/9.28          | 
|POLY-3 PERCENT (g) |        9.5%             17.3%            15.4%            39.3%            4.1%             0.0%            | 
|TERMINAL (d)       |        2/27 (7%)        0/17 (0%)        3/24 (13%)       5/15 (33%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        672              525              443              541              548              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.202          P=0.181          P=0.295          P<0.001 **       P=0.560          P=1.000N        | 
|POLY 3             |        P=0.530N         P=0.250          P=0.317          P<0.001 **       P=0.381N         P=0.426N        | 
|POLY 1.5           |        P=0.093N         P=0.275          P=0.336          P<0.001 **       P=0.281N         P=0.226N        | 
|POLY 6             |        P=0.060          P=0.231          P=0.299          P<0.001 **       P=0.536N         P=0.574N        | 
|LOGISTIC REGRESSION|        P=0.065N         P=0.275          P=0.317          P=0.002 **       P=0.483N         P=0.876N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.346          P=0.371          P=0.003 **       P=0.181N         P=0.038N*       | 
|ORDER RESTRICTED   |        P=0.327N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        2/53 (4%)        1/53 (2%)        3/53 (6%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/32.58          2/37.79          1/37.16          3/25.16          2/10.57         | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             5.3%             2.7%             11.9%            18.9%           | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        2/24 (8%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          726 (T)          604              523              243             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.408          P=0.212          P=0.468          P=0.011 *        P=0.033 *       | 
|POLY 3             |        P=0.021 *        P=0.450          P=0.214          P=0.476          P=0.054          P=0.092         | 
|POLY 1.5           |        P=0.046 *        P=0.464          P=0.223          P=0.484          P=0.077          P=0.133         | 
|POLY 6             |        P=0.013 *        P=0.437          P=0.206          P=0.463          P=0.034 *        P=0.075         | 
|LOGISTIC REGRESSION|        P=0.022 *        P=0.408          P=0.212          P=0.515          P=0.086          P=0.300         | 
|COCH-ARM / FISHERS |        P=0.220          P=0.490          P=0.248          P=0.500          P=0.121          P=0.301         | 
|ORDER RESTRICTED   |        P=0.079          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/53 (51%)      16/51 (31%)      10/53 (19%)      8/53 (15%)       4/53 (8%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        27/45.63         16/36.90         10/38.79         8/39.71          4/26.06          0/9.28          | 
|POLY-3 PERCENT (g) |        59.2%            43.4%            25.8%            20.2%            15.4%            0.0%            | 
|TERMINAL (d)       |        16/27 (59%)      4/17 (24%)       7/24 (29%)       1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              364              608              367              496              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.163N         P=0.385N         P=0.005N**       P=0.015N*        P=0.582          P=0.681N        | 
|POLY 3             |        P<0.001N**       P=0.106N         P<0.001N**       P<0.001N**       P<0.001N**       P=0.025N*       | 
|POLY 1.5           |        P<0.001N**       P=0.076N         P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 6             |        P<0.001N**       P=0.135N         P=0.002N**       P<0.001N**       P=0.013N*        P=0.321N        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.114N         P<0.001N**       P<0.001N**       P<0.001N**       P=0.029N*       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.034N*        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.020N*        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        2/51 (4%)        3/53 (6%)        21/53 (40%)      42/53 (79%)      29/65 (45%)     | 
|POLY-3 RATE (b)    |        1/41.89          2/32.58          3/38.59          21/40.03         42/45.21         29/31.95        | 
|POLY-3 PERCENT (g) |        2.4%             6.1%             7.8%             52.5%            92.9%            90.8%           | 
|TERMINAL (d)       |        1/27 (4%)        2/17 (12%)       2/24 (8%)        11/15 (73%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          726 (T)          426              548              267              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.339          P=0.275          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.413          P=0.275          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.437          P=0.286          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.390          P=0.265          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.339          P=0.296          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.485          P=0.309          P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        1/51 (2%)        0/53 (0%)        1/53 (2%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        5/42.17          1/32.58          0/37.79          1/36.73          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        11.9%            3.1%             0.0%             2.7%             0.0%             0.0%            | 
|TERMINAL (d)       |        4/27 (15%)       1/17 (6%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        651              726 (T)          ---              726 (T)          ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.449N         P=0.230N         P=0.045N*        P=0.253N         P=0.790N         P=1.000N        | 
|POLY 3             |        P=0.072N         P=0.171N         P=0.040N*        P=0.135N         P=0.117N         P=0.379N        | 
|POLY 1.5           |        P=0.056N         P=0.150N         P=0.036N*        P=0.122N         P=0.066N         P=0.169N        | 
|POLY 6             |        P=0.080N         P=0.196N         P=0.044N*        P=0.158N         P=0.233N         P=0.550N        | 
|LOGISTIC REGRESSION|        P=0.274N         P=0.202N         P=0.046N*        P=0.187N         P=0.377N         P=0.931N        | 
|COCH-ARM / FISHERS |        P=0.026N*        P=0.112N         P=0.028N*        P=0.103N         P=0.028N*        P=0.016N*       | 
|ORDER RESTRICTED   |        P=0.270N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/53 (19%)      21/51 (41%)      23/53 (43%)      15/53 (28%)      6/53 (11%)       10/65 (15%)     | 
|POLY-3 RATE (b)    |        10/43.62         21/39.54         23/45.27         15/43.64         6/28.39          10/18.34        | 
|POLY-3 PERCENT (g) |        22.9%            53.1%            50.8%            34.4%            21.1%            54.5%           | 
|TERMINAL (d)       |        6/27 (22%)       5/17 (29%)       8/24 (33%)       0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              347              408              367              267              174             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.002 **       P=0.005 **       P=0.070          P=0.118          P<0.001 **      | 
|POLY 3             |        P=0.282N         P=0.003 **       P=0.004 **       P=0.168          P=0.543N         P=0.033 *       | 
|POLY 1.5           |        P=0.057N         P=0.004 **       P=0.004 **       P=0.165          P=0.374N         P=0.176         | 
|POLY 6             |        P=0.366          P=0.003 **       P=0.005 **       P=0.167          P=0.432          P=0.007 **      | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.006 **       P=0.006 **       P=0.213          P=0.120N         P=0.333N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.011 *        P=0.006 **       P=0.180          P=0.208N         P=0.398N        | 
|ORDER RESTRICTED   |        P=0.039 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        14/51 (27%)      27/53 (51%)      45/53 (85%)      49/53 (92%)      56/65 (86%)     | 
|POLY-3 RATE (b)    |        3/42.21          14/36.10         27/43.56         45/47.56         49/50.59         56/57.00        | 
|POLY-3 PERCENT (g) |        7.1%             38.8%            62.0%            94.6%            96.9%            98.3%           | 
|TERMINAL (d)       |        2/27 (7%)        6/17 (35%)       14/24 (58%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        639              275              408              390              267              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/53 (19%)      10/51 (20%)      6/53 (11%)       1/53 (2%)        10/53 (19%)      6/65 (9%)       | 
|POLY-3 RATE (b)    |        10/43.19         10/35.36         6/38.55          1/36.81          10/28.59         6/13.82         | 
|POLY-3 PERCENT (g) |        23.2%            28.3%            15.6%            2.7%             35.0%            43.4%           | 
|TERMINAL (d)       |        5/27 (19%)       5/17 (29%)       4/24 (17%)       0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        586              498              572              707              383              329             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.239          P=0.312N         P=0.037N*        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.109          P=0.398          P=0.279N         P=0.008N**       P=0.207          P=0.199         | 
|POLY 1.5           |        P=0.252          P=0.445          P=0.250N         P=0.007N**       P=0.365          P=0.522         | 
|POLY 6             |        P=0.049 *        P=0.355          P=0.313N         P=0.013N*        P=0.074          P=0.080         | 
|LOGISTIC REGRESSION|        P=0.106          P=0.416          P=0.279N         P=0.011N*        P=0.258          P=0.228         | 
|COCH-ARM / FISHERS |        P=0.238N         P=0.560          P=0.208N         P=0.004N**       P=0.598N         P=0.106N        | 
|ORDER RESTRICTED   |        P=0.109          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/53 (51%)      27/51 (53%)      30/53 (57%)      32/53 (60%)      22/53 (42%)      11/65 (17%)     | 
|POLY-3 RATE (b)    |        27/48.61         27/41.24         30/45.25         32/43.72         22/33.87         11/17.99        | 
|POLY-3 PERCENT (g) |        55.6%            65.5%            66.3%            73.2%            65.0%            61.1%           | 
|TERMINAL (d)       |        11/27 (41%)      9/17 (53%)       14/24 (58%)      13/15 (87%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              364              443              41               267              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.097          P=0.198          P=0.014 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.355          P=0.224          P=0.189          P=0.050          P=0.257          P=0.456         | 
|POLY 1.5           |        P=0.075N         P=0.277          P=0.231          P=0.094          P=0.546          P=0.142N        | 
|POLY 6             |        P=0.020 *        P=0.197          P=0.160          P=0.019 *        P=0.058          P=0.122         | 
|LOGISTIC REGRESSION|        P=0.015N*        P=0.436          P=0.335          P=0.182          P=0.444N         P=0.014N*       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.497          P=0.349          P=0.217          P=0.218N         P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.399          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        2/51 (4%)        0/53 (0%)        2/53 (4%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        2/41.89          2/33.21          0/37.79          2/37.47          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        4.8%             6.0%             0.0%             5.3%             0.0%             0.0%            | 
|TERMINAL (d)       |        2/27 (7%)        1/17 (6%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          525              ---              555              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.576N         P=0.540          P=0.264N         P=0.543          P=1.000N         P=1.000N        | 
|POLY 3             |        P=0.295N         P=0.608          P=0.260N         P=0.654          P=0.377N         P=0.563N        | 
|POLY 1.5           |        P=0.191N         P=0.631          P=0.252N         P=0.667          P=0.310N         P=0.423N        | 
|POLY 6             |        P=0.429N         P=0.586          P=0.269N         P=0.632          P=0.478N         P=0.650N        | 
|LOGISTIC REGRESSION|        P=0.185N         P=0.613          (e)              P=0.661          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.066N         P=0.676          P=0.248N         P=0.691N         P=0.248N         P=0.200N        | 
|ORDER RESTRICTED   |        P=0.565N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        10/53 (19%)      45/53 (85%)      50/53 (94%)      61/65 (94%)     | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          10/39.24         45/47.09         50/50.87         61/61.04        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             25.5%            95.6%            98.3%            99.9%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        7/24 (29%)       15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              474              480              267              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        49/53 (92%)      47/51 (92%)      50/53 (94%)      52/53 (98%)      51/53 (96%)      64/65 (98%)     | 
|POLY-3 RATE (b)    |        49/51.05         47/49.76         50/51.37         52/53.00         51/51.92         64/64.15        | 
|POLY-3 PERCENT (g) |        96.0%            94.5%            97.3%            98.1%            98.2%            99.8%           | 
|TERMINAL (d)       |        26/27 (96%)      15/17 (88%)      24/24 (100%)     14/15 (93%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        313              70               399              41               166              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.030 *        P=0.190          P=0.007 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.050          P=0.546N         P=0.578          P=0.473          P=0.455          P=0.171         | 
|POLY 1.5           |        P=0.056          P=0.569N         P=0.504          P=0.345          P=0.427          P=0.137         | 
|POLY 6             |        P=0.053          P=0.516N         P=0.649          P=0.619          P=0.466          P=0.265         | 
|LOGISTIC REGRESSION|        P=0.020 *        P=0.583          P=0.351          P=0.133          P=0.176          P=0.054         | 
|COCH-ARM / FISHERS |        P=0.061          P=0.620N         P=0.500          P=0.181          P=0.339          P=0.125         | 
|ORDER RESTRICTED   |        P=0.056          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        4/53 (8%)        4/65 (6%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          4/26.18          4/11.99         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             15.3%            33.4%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              447              338             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.016 *        P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.021 *        P=0.009 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.034 *        P=0.018 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.011 *        P=0.006 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.096          P=0.014 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.059          P=0.088         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        38/53 (72%)      28/51 (55%)      32/53 (60%)      16/53 (30%)      2/53 (4%)        3/65 (5%)       | 
|POLY-3 RATE (b)    |        38/45.68         28/38.34         32/44.02         16/38.41         2/24.80          3/11.13         | 
|POLY-3 PERCENT (g) |        83.2%            73.0%            72.7%            41.7%            8.1%             27.0%           | 
|TERMINAL (d)       |        26/27 (96%)      15/17 (88%)      20/24 (83%)      10/15 (67%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              443              408              534              482              429             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.368N         P=0.319          P=0.452N         P=0.035N*        P=0.388N         P=0.005 **      | 
|POLY 3             |        P<0.001N**       P=0.161N         P=0.140N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001N**       P=0.127N         P=0.146N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 6             |        P<0.001N**       P=0.181N         P=0.135N         P<0.001N**       P<0.001N**       P=0.254N        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.419N         P=0.346N         P<0.001N**       P<0.001N**       P=0.587N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.057N         P=0.153N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        13/51 (25%)      6/53 (11%)       26/53 (49%)      17/53 (32%)      27/65 (42%)     | 
|POLY-3 RATE (b)    |        3/42.94          13/38.42         6/40.55          26/46.15         17/33.43         27/31.21        | 
|POLY-3 PERCENT (g) |        7.0%             33.8%            14.8%            56.3%            50.9%            86.5%           | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        0/24 (0%)        4/15 (27%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        564              347              408              78               313              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P=0.192          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.002 **       P=0.212          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.002 **       P=0.223          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.002 **       P=0.204          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.003 **       P=0.010 *        P=0.291          P<0.001 **       P=0.003 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.005 **       P=0.244          P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        18/51 (35%)      38/53 (72%)      52/53 (98%)      53/53 (100%)     60/65 (92%)     | 
|POLY-3 RATE (b)    |        5/43.23          18/37.02         38/46.33         52/52.00         53/53.00         60/60.56        | 
|POLY-3 PERCENT (g) |        11.6%            48.6%            82.0%            100.0%           100.0%           99.1%           | 
|TERMINAL (d)       |        2/27 (7%)        8/17 (47%)       20/24 (83%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              328              408              78               166              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        8/51 (16%)       32/53 (60%)      51/53 (96%)      52/53 (98%)      64/65 (98%)     | 
|POLY-3 RATE (b)    |        0/41.89          8/34.02          32/44.65         51/51.00         52/52.01         64/64.00        | 
|POLY-3 PERCENT (g) |        0.0%             23.5%            71.7%            100.0%           100.0%           100.0%          | 
|TERMINAL (d)       |        0/27 (0%)        4/17 (24%)       18/24 (75%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              484              408              261              267              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        3/51 (6%)        3/53 (6%)        14/53 (26%)      25/53 (47%)      14/65 (22%)     | 
|POLY-3 RATE (b)    |        4/42.10          3/33.78          3/37.79          14/37.69         25/34.09         14/19.17        | 
|POLY-3 PERCENT (g) |        9.5%             8.9%             7.9%             37.1%            73.4%            73.0%           | 
|TERMINAL (d)       |        3/27 (11%)       0/17 (0%)        3/24 (13%)       8/15 (53%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        672              525              726 (T)          636              447              289             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.600          P=0.571N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.619N         P=0.559N         P=0.002 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.590N         P=0.537N         P=0.004 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.643N         P=0.583N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.608N         P=0.581N         P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.522N         P=0.500N         P=0.009 **       P<0.001 **       P=0.030 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/53 (11%)       2/51 (4%)        3/53 (6%)        10/53 (19%)      3/53 (6%)        4/65 (6%)       | 
|POLY-3 RATE (b)    |        6/42.12          2/32.58          3/38.68          10/39.53         3/25.25          4/12.37         | 
|POLY-3 PERCENT (g) |        14.2%            6.1%             7.8%             25.3%            11.9%            32.3%           | 
|TERMINAL (d)       |        5/27 (19%)       2/17 (12%)       1/24 (4%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        665              726 (T)          586              537              482              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.322N         P=0.320N         P=0.063          P=0.050          P=0.004 **      | 
|POLY 3             |        P=0.132          P=0.230N         P=0.284N         P=0.161          P=0.535N         P=0.229         | 
|POLY 1.5           |        P=0.334          P=0.200N         P=0.269N         P=0.172          P=0.396N         P=0.489         | 
|POLY 6             |        P=0.030 *        P=0.264N         P=0.295N         P=0.147          P=0.544          P=0.115         | 
|LOGISTIC REGRESSION|        P=0.172          P=0.285N         P=0.299N         P=0.148          P=0.576          P=0.362         | 
|COCH-ARM / FISHERS |        P=0.251N         P=0.148N         P=0.244N         P=0.208          P=0.244N         P=0.251N        | 
|ORDER RESTRICTED   |        P=0.141          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        5/51 (10%)       7/53 (13%)       46/53 (87%)      52/53 (98%)      60/65 (92%)     | 
|POLY-3 RATE (b)    |        5/42.04          5/32.90          7/38.20          46/48.29         52/52.01         60/60.13        | 
|POLY-3 PERCENT (g) |        11.9%            15.2%            18.3%            95.3%            100.0%           99.8%           | 
|TERMINAL (d)       |        4/27 (15%)       4/17 (24%)       6/24 (25%)       14/15 (93%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        687              639              608              367              267              174             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.339          P=0.290          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.470          P=0.310          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.514          P=0.336          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.427          P=0.287          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.387          P=0.273          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.605          P=0.380          P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        3/51 (6%)        8/53 (15%)       8/53 (15%)       3/53 (6%)        8/65 (12%)      | 
|POLY-3 RATE (b)    |        2/42.71          3/34.67          8/41.87          8/39.66          3/26.01          8/16.92         | 
|POLY-3 PERCENT (g) |        4.7%             8.7%             19.1%            20.2%            11.5%            47.3%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        564              436              399              367              313              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.384          P=0.040 *        P=0.030 *        P=0.243          P=0.006 **      | 
|POLY 3             |        P=0.017 *        P=0.406          P=0.040 *        P=0.032 *        P=0.291          P<0.001 **      | 
|POLY 1.5           |        P=0.063          P=0.429          P=0.042 *        P=0.036 *        P=0.381          P=0.006 **      | 
|POLY 6             |        P=0.002 **       P=0.383          P=0.040 *        P=0.027 *        P=0.187          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.171N         P=0.623          P=0.072          P=0.056          P=0.652N         P=0.493N        | 
|COCH-ARM / FISHERS |        P=0.340          P=0.482          P=0.046 *        P=0.046 *        P=0.500          P=0.091         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        7/53 (13%)       36/53 (68%)      52/53 (98%)      57/65 (88%)     | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          7/40.39          36/46.63         52/52.01         57/59.02        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             17.3%            77.2%            100.0%           96.6%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        3/24 (13%)       8/15 (53%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              408              367              267              174             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.008 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.006 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.007 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.006 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.012 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.006 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Glandular Structures                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        1/53 (2%)        5/53 (9%)        25/65 (38%)     | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          1/37.09          5/26.22          25/31.26        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.7%             19.1%            80.0%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              628              450              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.462          P=0.002 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.476          P=0.008 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.484          P=0.014 *        P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.462          P=0.003 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.504          P=0.027 *        P=0.007 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.500          P=0.028 *        P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        16/51 (31%)      22/53 (42%)      47/53 (89%)      52/53 (98%)      65/65 (100%)    | 
|POLY-3 RATE (b)    |        0/41.89          16/37.84         22/43.78         47/48.93         52/52.01         65/65.00        | 
|POLY-3 PERCENT (g) |        0.0%             42.3%            50.3%            96.1%            100.0%           100.0%          | 
|TERMINAL (d)       |        0/27 (0%)        4/17 (24%)       9/24 (38%)       14/15 (93%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              400              443              367              267              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        9/51 (18%)       21/53 (40%)      48/53 (91%)      52/53 (98%)      48/65 (74%)     | 
|POLY-3 RATE (b)    |        0/41.89          9/33.70          21/42.85         48/50.29         52/52.80         48/50.32        | 
|POLY-3 PERCENT (g) |        0.0%             26.7%            49.0%            95.4%            98.5%            95.4%           | 
|TERMINAL (d)       |        0/27 (0%)        6/17 (35%)       10/24 (42%)      14/15 (93%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              484              408              261              166              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        4/51 (8%)        23/53 (43%)      49/53 (92%)      52/53 (98%)      62/65 (95%)     | 
|POLY-3 RATE (b)    |        4/41.89          4/33.76          23/41.82         49/49.34         52/52.01         62/62.03        | 
|POLY-3 PERCENT (g) |        9.6%             11.9%            55.0%            99.3%            100.0%           100.0%          | 
|TERMINAL (d)       |        4/27 (15%)       2/17 (12%)       14/24 (58%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          374              455              367              267              174             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.412          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.521          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.552          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.491          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.525          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.620          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        2/53 (4%)        37/53 (70%)      52/53 (98%)      58/65 (89%)     | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          2/38.51          37/45.40         52/52.01         58/58.27        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.2%             81.5%            100.0%           99.5%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        1/24 (4%)        10/15 (67%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              474              480              267              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.216          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.218          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.225          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.212          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.253          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.248          P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Serosa                                                                                                                    | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/51 (4%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          2/33.29          0/37.79          0/36.73          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        0.0%             6.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              525              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.499N         P=0.169          (e)              (e)              (e)              (e)             | 
|POLY 3             |        P=0.365N         P=0.189          (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.329N         P=0.201          (e)              (e)              (e)              (e)             | 
|POLY 6             |        P=0.361N         P=0.179          (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.238N         P=0.228          (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.208N         P=0.238          (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.607N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        2/53 (4%)        0/53 (0%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          2/38.58          0/23.94          0/9.33          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.2%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              41               ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.516N         (e)              (e)              P=0.238          (e)              (e)             | 
|POLY 3             |        P=0.439          (e)              (e)              P=0.219          (e)              (e)             | 
|POLY 1.5           |        P=0.641          (e)              (e)              P=0.227          (e)              (e)             | 
|POLY 6             |        P=0.177          (e)              (e)              P=0.205          (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.164N         (e)              (e)              P=0.558          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.438N         (e)              (e)              P=0.248          (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.594          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        1/53 (2%)        2/53 (4%)        4/66 (6%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          1/37.73          2/25.26          4/12.86         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.7%             7.9%             31.1%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              41               397              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.500          P=0.142          P=0.016 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.479          P=0.146          P=0.009 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.488          P=0.182          P=0.019 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.465          P=0.109          P=0.006 **      | 
|LOGISTIC REGRESSION|        P=0.129          (e)              (e)              (e)              P=0.371          P=0.397         | 
|COCH-ARM / FISHERS |        P=0.003 **       (e)              (e)              P=0.500          P=0.248          P=0.091         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/53 (75%)      33/51 (65%)      46/53 (87%)      48/53 (91%)      46/53 (87%)      33/66 (50%)     | 
|POLY-3 RATE (b)    |        40/49.03         33/40.13         46/48.47         48/49.70         46/48.95         33/37.16        | 
|POLY-3 PERCENT (g) |        81.6%            82.2%            94.9%            96.6%            94.0%            88.8%           | 
|TERMINAL (d)       |        21/27 (78%)      15/17 (88%)      24/24 (100%)     15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        362              374              408              261              267              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.174          P=0.060          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.134          P=0.584          P=0.027 *        P=0.011 *        P=0.040 *        P=0.245         | 
|POLY 1.5           |        P=0.450N         P=0.469N         P=0.042 *        P=0.011 *        P=0.062          P=0.456N        | 
|POLY 6             |        P=0.019 *        P=0.426          P=0.019 *        P=0.009 **       P=0.019 *        P=0.064         | 
|LOGISTIC REGRESSION|        P=0.090          P=0.542N         P=0.037 *        P=0.008 **       P=0.035 *        P=0.519         | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.162N         P=0.107          P=0.034 *        P=0.107          P=0.004N**      | 
|ORDER RESTRICTED   |        P=0.019 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        9/51 (18%)       7/53 (13%)       3/53 (6%)        2/53 (4%)        2/66 (3%)       | 
|POLY-3 RATE (b)    |        5/43.02          9/35.07          7/38.67          3/38.32          2/25.16          2/11.03         | 
|POLY-3 PERCENT (g) |        11.6%            25.7%            18.1%            7.8%             8.0%             18.1%           | 
|TERMINAL (d)       |        3/27 (11%)       3/17 (18%)       5/24 (21%)       0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              70               523              539              504              243             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.215          P=0.062          P=0.297          P=0.512N         P=0.502          P=0.162         | 
|POLY 3             |        P=0.164N         P=0.093          P=0.304          P=0.421N         P=0.474N         P=0.481         | 
|POLY 1.5           |        P=0.076N         P=0.116          P=0.332          P=0.399N         P=0.350N         P=0.545N        | 
|POLY 6             |        P=0.269N         P=0.077          P=0.277          P=0.456N         P=0.646          P=0.315         | 
|LOGISTIC REGRESSION|        P=0.021N*        P=0.163          P=0.327          P=0.335N         P=0.275N         P=0.471N        | 
|COCH-ARM / FISHERS |        P=0.005N**       P=0.174          P=0.380          P=0.358N         P=0.219N         P=0.140N        | 
|ORDER RESTRICTED   |        P=0.579N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        2/53 (4%)        14/53 (26%)      16/53 (30%)      7/66 (11%)      | 
|POLY-3 RATE (b)    |        0/41.89          1/32.58          2/38.20          14/37.93         16/31.82         7/14.88         | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             5.2%             36.9%            50.3%            47.1%           | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        1/24 (4%)        10/15 (67%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          608              567              313              289             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.408          P=0.207          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.450          P=0.217          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.464          P=0.224          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.437          P=0.210          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.408          P=0.224          P<0.001 **       P<0.001 **       P=0.019 *       | 
|COCH-ARM / FISHERS |        P=0.007 **       P=0.490          P=0.248          P<0.001 **       P<0.001 **       P=0.014 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/53 (34%)      10/51 (20%)      2/53 (4%)        1/53 (2%)        1/53 (2%)        4/66 (6%)       | 
|POLY-3 RATE (b)    |        18/43.48         10/33.86         2/37.79          1/36.73          1/24.56          4/12.41         | 
|POLY-3 PERCENT (g) |        41.4%            29.5%            5.3%             2.7%             4.1%             32.2%           | 
|TERMINAL (d)       |        13/27 (48%)      7/17 (41%)       2/24 (8%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              443              726 (T)          726 (T)          525              303             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.037 *        P=0.394N         P<0.001N**       P<0.001N**       P=0.487N         P=0.002 **      | 
|POLY 3             |        P=0.003N**       P=0.197N         P<0.001N**       P<0.001N**       P<0.001N**       P=0.426N        | 
|POLY 1.5           |        P=0.002N**       P=0.147N         P<0.001N**       P<0.001N**       P<0.001N**       P=0.064N        | 
|POLY 6             |        P=0.003N**       P=0.265N         P<0.001N**       P<0.001N**       P=0.021N*        P=0.408         | 
|LOGISTIC REGRESSION|        P=0.204N         P=0.244N         P<0.001N**       P<0.001N**       P=0.012N*        P=0.586         | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.076N         P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.033N*        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        14/51 (27%)      39/53 (74%)      46/53 (87%)      35/53 (66%)      8/66 (12%)      | 
|POLY-3 RATE (b)    |        1/41.89          14/35.34         39/46.42         46/47.90         35/41.87         8/16.09         | 
|POLY-3 PERCENT (g) |        2.4%             39.6%            84.0%            96.0%            83.6%            49.7%           | 
|TERMINAL (d)       |        1/27 (4%)        7/17 (41%)       21/24 (88%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          498              408              367              267              267             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P=0.002 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.030 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P=0.066         | 
|COCH-ARM / FISHERS |        P=0.011N*        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P=0.035 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Serosa                                                                                                                     | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        0/51 (0%)        0/53 (0%)        1/53 (2%)        16/53 (30%)      8/66 (12%)      | 
|POLY-3 RATE (b)    |        3/42.18          0/32.58          0/37.79          1/36.96          16/32.54         8/15.93         | 
|POLY-3 PERCENT (g) |        7.1%             0.0%             0.0%             2.7%             49.2%            50.2%           | 
|TERMINAL (d)       |        2/27 (7%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        649              ---              ---              667              349              294             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.208N         P=0.148N         P=0.460N         P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.171N         P=0.139N         P=0.353N         P<0.001 **       P=0.003 **      | 
|POLY 1.5           |        P<0.001 **       P=0.155N         P=0.131N         P=0.336N         P<0.001 **       P=0.014 *       | 
|POLY 6             |        P<0.001 **       P=0.189N         P=0.147N         P=0.382N         P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.180N         P=0.144N         P=0.370N         P<0.001 **       P=0.084         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.129N         P=0.121N         P=0.309N         P<0.001 **       P=0.188         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        2/51 (4%)        3/53 (6%)        4/52 (8%)        4/52 (8%)        1/66 (2%)       | 
|POLY-3 RATE (b)    |        3/42.29          2/33.39          3/37.79          4/36.92          4/25.87          1/10.25         | 
|POLY-3 PERCENT (g) |        7.1%             6.0%             7.9%             10.8%            15.5%            9.8%            | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        3/24 (13%)       2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        639              567              726 (T)          602              383              313             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.666N         P=0.597          P=0.290          P=0.029 *        P=0.427         | 
|POLY 3             |        P=0.145          P=0.606N         P=0.610          P=0.426          P=0.254          P=0.594         | 
|POLY 1.5           |        P=0.364          P=0.579N         P=0.630          P=0.448          P=0.355          P=0.565N        | 
|POLY 6             |        P=0.048 *        P=0.631N         P=0.588          P=0.390          P=0.146          P=0.452         | 
|LOGISTIC REGRESSION|        P=0.325          P=0.575N         P=0.596          P=0.410          P=0.395          P=0.723N        | 
|COCH-ARM / FISHERS |        P=0.221N         P=0.518N         P=0.661N         P=0.489          P=0.489          P=0.232N        | 
|ORDER RESTRICTED   |        P=0.589          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        1/53 (2%)        0/52 (0%)        2/52 (4%)        7/66 (11%)      | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          1/37.79          0/36.34          2/25.70          7/15.76         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.7%             0.0%             7.8%             44.4%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        1/24 (4%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              726 (T)          ---              313              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.477          (e)              P=0.231          P=0.004 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.479          (e)              P=0.148          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.487          (e)              P=0.183          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.472          (e)              P=0.109          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.027 *        (e)              P=0.477          (e)              P=0.377          P=0.363         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          (e)              P=0.243          P=0.014 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        45/53 (85%)      35/51 (69%)      34/53 (64%)      27/52 (52%)      22/52 (42%)      20/66 (30%)     | 
|POLY-3 RATE (b)    |        45/51.67         35/41.98         34/46.81         27/43.88         22/36.54         20/26.79        | 
|POLY-3 PERCENT (g) |        87.1%            83.4%            72.6%            61.5%            60.2%            74.7%           | 
|TERMINAL (d)       |        24/27 (89%)      15/17 (88%)      17/24 (71%)      7/15 (47%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              70               408              261              337              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.288          P=0.226N         P=0.265N         P=0.006 **       P<0.001 **      | 
|POLY 3             |        P=0.010N*        P=0.409N         P=0.049N*        P=0.002N**       P<0.001N**       P=0.122N        | 
|POLY 1.5           |        P<0.001N**       P=0.227N         P=0.032N*        P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 6             |        P=0.158N         P=0.579N         P=0.073N         P=0.004N**       P=0.026N*        P=0.546         | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.114N         P=0.016N*        P<0.001N**       P<0.001N**       P<0.001N**      | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.041N*        P=0.012N*        P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.019N*        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        3/53 (6%)        0/52 (0%)        2/52 (4%)        1/66 (2%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/32.58          3/38.56          0/36.34          2/24.19          1/10.31         | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             7.8%             0.0%             8.3%             9.7%            | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        2/24 (8%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          443              ---              674              174             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       P=0.408          P=0.108          (e)              P=0.002 **       P=0.538         | 
|POLY 3             |        P=0.195          P=0.450          P=0.104          (e)              P=0.140          P=0.308         | 
|POLY 1.5           |        P=0.290          P=0.464          P=0.109          (e)              P=0.177          P=0.380         | 
|POLY 6             |        P=0.150          P=0.437          P=0.099          (e)              P=0.102          P=0.268         | 
|LOGISTIC REGRESSION|        P=0.360          P=0.408          P=0.122          (e)              P=0.016 *        (e)             | 
|COCH-ARM / FISHERS |        P=0.576          P=0.490          P=0.121          (e)              P=0.243          P=0.555         | 
|ORDER RESTRICTED   |        P=0.320          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        1/51 (2%)        0/53 (0%)        2/53 (4%)        1/52 (2%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        1/41.89          1/32.58          0/37.79          2/37.58          1/24.16          2/11.14         | 
|POLY-3 PERCENT (g) |        2.4%             3.1%             0.0%             5.3%             4.1%             18.0%           | 
|TERMINAL (d)       |        1/27 (4%)        1/17 (6%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          726 (T)          ---              567              530              245             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.656          P=0.523N         P=0.400          P=0.402          P=0.183         | 
|POLY 3             |        P=0.138          P=0.702          P=0.521N         P=0.462          P=0.626          P=0.193         | 
|POLY 1.5           |        P=0.175          P=0.719          P=0.513N         P=0.475          P=0.688          P=0.298         | 
|POLY 6             |        P=0.105          P=0.685          P=0.528N         P=0.442          P=0.533          P=0.142         | 
|LOGISTIC REGRESSION|        P=0.352          P=0.656          (e)              P=0.493          P=0.726          P=0.813         | 
|COCH-ARM / FISHERS |        P=0.330          P=0.743          P=0.500N         P=0.500          P=0.748          P=0.577         | 
|ORDER RESTRICTED   |        P=0.078          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/51 (4%)        2/53 (4%)        2/53 (4%)        4/52 (8%)        14/65 (22%)     | 
|POLY-3 RATE (b)    |        0/41.89          2/32.67          2/38.31          2/37.59          4/26.33          14/22.13        | 
|POLY-3 PERCENT (g) |        0.0%             6.1%             5.2%             5.3%             15.2%            63.3%           | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        1/24 (4%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              705              567              537              313              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.149          P=0.214          P=0.220          P=0.022 *        P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.186          P=0.217          P=0.213          P=0.021 *        P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.199          P=0.224          P=0.221          P=0.034 *        P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.174          P=0.211          P=0.201          P=0.011 *        P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.004 **       P=0.157          P=0.233          P=0.254          P=0.188          P=0.136         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.238          P=0.248          P=0.248          P=0.057          P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        0/51 (0%)        1/53 (2%)        6/53 (11%)       5/52 (10%)       0/65 (0%)       | 
|POLY-3 RATE (b)    |        3/42.49          0/32.58          1/38.20          6/38.25          5/26.76          0/9.28          | 
|POLY-3 PERCENT (g) |        7.1%             0.0%             2.6%             15.7%            18.7%            0.0%            | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        639              ---              608              565              337              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.201N         P=0.371N         P=0.137          P=0.048 *        P=1.000N        | 
|POLY 3             |        P=0.016 *        P=0.173N         P=0.344N         P=0.190          P=0.147          P=0.486N        | 
|POLY 1.5           |        P=0.137          P=0.156N         P=0.329N         P=0.207          P=0.223          P=0.307N        | 
|POLY 6             |        P<0.001 **       P=0.192N         P=0.359N         P=0.166          P=0.076          P=0.606N        | 
|LOGISTIC REGRESSION|        P=0.464          P=0.156N         P=0.315N         P=0.209          P=0.458          P=0.661N        | 
|COCH-ARM / FISHERS |        P=0.332N         P=0.129N         P=0.309N         P=0.244          P=0.347          P=0.088N        | 
|ORDER RESTRICTED   |        P=0.451          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/28 (25%)       7/16 (44%)       7/16 (44%)       7/25 (28%)       7/20 (35%)       27/45 (60%)     | 
|POLY-3 RATE (b)    |        7/23.39          7/13.62          7/13.19          7/18.37          7/13.66          27/29.76        | 
|POLY-3 PERCENT (g) |        29.9%            51.4%            53.1%            38.1%            51.3%            90.7%           | 
|TERMINAL (d)       |        2/12 (17%)       1/4 (25%)        3/7 (43%)        0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              275              443              534              313              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.279          P=0.402          P=0.369          P=0.021 *        P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.166          P=0.147          P=0.411          P=0.172          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.169          P=0.145          P=0.460          P=0.238          P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.164          P=0.153          P=0.347          P=0.101          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.104          P=0.215          P=0.181          P=0.532          P=0.468          P=0.140         | 
|COCH-ARM / FISHERS |        P=0.004 **       P=0.171          P=0.171          P=0.525          P=0.332          P=0.003 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/28 (7%)        2/16 (13%)       4/16 (25%)       15/25 (60%)      7/20 (35%)       25/45 (56%)     | 
|POLY-3 RATE (b)    |        2/21.96          2/10.73          4/11.85          15/21.55         7/14.28          25/28.50        | 
|POLY-3 PERCENT (g) |        9.1%             18.6%            33.8%            69.6%            49.0%            87.7%           | 
|TERMINAL (d)       |        0/12 (0%)        1/4 (25%)        2/7 (29%)        2/5 (40%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        586              651              567              261              313              174             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.497          P=0.215          P<0.001 **       P=0.008 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.419          P=0.090          P<0.001 **       P=0.006 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.445          P=0.095          P<0.001 **       P=0.010 *        P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.385          P=0.087          P<0.001 **       P=0.002 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.017 *        P=0.450          P=0.103          P<0.001 **       P=0.060          P=0.042 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.463          P=0.116          P<0.001 **       P=0.020 *        P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/28 (0%)        3/16 (19%)       0/16 (0%)        3/25 (12%)       2/20 (10%)       2/45 (4%)       | 
|POLY-3 RATE (b)    |        0/21.26          3/11.72          0/10.91          3/17.31          2/10.58          2/7.29          | 
|POLY-3 PERCENT (g) |        0.0%             25.6%            0.0%             17.3%            18.9%            27.4%           | 
|TERMINAL (d)       |        0/12 (0%)        0/4 (0%)         0/7 (0%)         0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              525              ---              570              555              611             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.075          (e)              P=0.101          P=0.064          P<0.001 **      | 
|POLY 3             |        P=0.102          P=0.028 *        (e)              P=0.077          P=0.105          P=0.108         | 
|POLY 1.5           |        P=0.232          P=0.030 *        (e)              P=0.085          P=0.128          P=0.165         | 
|POLY 6             |        P=0.046 *        P=0.027 *        (e)              P=0.065          P=0.080          P=0.083         | 
|LOGISTIC REGRESSION|        P=0.165          P=0.044 *        (e)              P=0.102          P=0.150          P=0.004 **      | 
|COCH-ARM / FISHERS |        P=0.451N         P=0.042 *        (e)              P=0.098          P=0.168          P=0.377         | 
|ORDER RESTRICTED   |        P=0.086          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/28 (0%)        0/16 (0%)        2/16 (13%)       0/25 (0%)        0/20 (0%)        0/45 (0%)       | 
|POLY-3 RATE (b)    |        0/21.26          0/10.45          2/11.58          0/16.09          0/9.74           0/6.56          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             17.3%            0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/4 (0%)         1/7 (14%)        0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              504              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.629N         (e)              P=0.171          (e)              (e)              (e)             | 
|POLY 3             |        P=0.452N         (e)              P=0.108          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.349N         (e)              P=0.110          (e)              (e)              (e)             | 
|POLY 6             |        P=0.545N         (e)              P=0.106          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.273N         (e)              P=0.124          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.188N         (e)              P=0.127          (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.551N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/28 (0%)        0/16 (0%)        0/16 (0%)        0/25 (0%)        0/20 (0%)        2/45 (4%)       | 
|POLY-3 RATE (b)    |        0/21.26          0/10.45          0/10.91          0/16.09          0/9.74           2/8.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             24.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/4 (0%)         0/7 (0%)         0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              289             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.036 *       | 
|POLY 3             |        P=0.120          (e)              (e)              (e)              (e)              P=0.114         | 
|POLY 1.5           |        P=0.068          (e)              (e)              (e)              (e)              P=0.171         | 
|POLY 6             |        P=0.169          (e)              (e)              (e)              (e)              P=0.087         | 
|LOGISTIC REGRESSION|        P=0.102          (e)              (e)              (e)              (e)              P=0.394         | 
|COCH-ARM / FISHERS |        P=0.053          (e)              (e)              (e)              (e)              P=0.377         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/28 (0%)        0/16 (0%)        0/16 (0%)        0/25 (0%)        1/20 (5%)        4/45 (9%)       | 
|POLY-3 RATE (b)    |        0/21.26          0/10.45          0/10.91          0/16.09          1/10.50          4/10.12         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             9.5%             39.5%           | 
|TERMINAL (d)       |        0/12 (0%)        0/4 (0%)         0/7 (0%)         0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              450              243             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.470          P=0.020 *       | 
|POLY 3             |        P=0.003 **       (e)              (e)              (e)              P=0.365          P=0.013 *       | 
|POLY 1.5           |        P=0.002 **       (e)              (e)              (e)              P=0.396          P=0.031 *       | 
|POLY 6             |        P=0.002 **       (e)              (e)              (e)              P=0.323          P=0.007 **      | 
|LOGISTIC REGRESSION|        P=0.095          (e)              (e)              (e)              P=0.515          P=0.412         | 
|COCH-ARM / FISHERS |        P=0.007 **       (e)              (e)              (e)              P=0.417          P=0.137         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/28 (0%)        0/16 (0%)        0/16 (0%)        1/25 (4%)        4/20 (20%)       3/45 (7%)       | 
|POLY-3 RATE (b)    |        0/21.26          0/10.45          0/10.91          1/16.37          4/11.19          3/8.86          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             6.1%             35.7%            33.9%           | 
|TERMINAL (d)       |        0/12 (0%)        0/4 (0%)         0/7 (0%)         0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              651              450              342             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.476          P<0.001 **       P=0.004 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.448          P=0.007 **       P=0.038 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.463          P=0.011 *        P=0.070         | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.423          P=0.003 **       P=0.025 *       | 
|LOGISTIC REGRESSION|        P=0.002 **       (e)              (e)              P=0.462          P=0.016 *        P=0.158         | 
|COCH-ARM / FISHERS |        P=0.040 *        (e)              (e)              P=0.472          P=0.025 *        P=0.228         | 
|ORDER RESTRICTED   |        P=0.005 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/28 (0%)        0/16 (0%)        0/16 (0%)        2/25 (8%)        0/20 (0%)        1/45 (2%)       | 
|POLY-3 RATE (b)    |        0/21.26          0/10.45          0/10.91          2/16.57          0/9.74           1/7.49          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             12.1%            0.0%             13.4%           | 
|TERMINAL (d)       |        0/12 (0%)        0/4 (0%)         0/7 (0%)         0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              662              ---              289             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.046 *        (e)              (e)              P=0.179          (e)              P=0.457         | 
|POLY 3             |        P=0.283          (e)              (e)              P=0.180          (e)              P=0.342         | 
|POLY 1.5           |        P=0.365          (e)              (e)              P=0.194          (e)              P=0.427         | 
|POLY 6             |        P=0.170          (e)              (e)              P=0.158          (e)              P=0.291         | 
|LOGISTIC REGRESSION|        P=0.505          (e)              (e)              P=0.179          (e)              P=0.934         | 
|COCH-ARM / FISHERS |        P=0.536          (e)              (e)              P=0.218          (e)              P=0.616         | 
|ORDER RESTRICTED   |        P=0.143          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/28 (0%)        0/16 (0%)        0/16 (0%)        0/25 (0%)        2/20 (10%)       2/45 (4%)       | 
|POLY-3 RATE (b)    |        0/21.26          0/10.45          0/10.91          0/16.09          2/10.45          2/7.54          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             19.1%            26.5%           | 
|TERMINAL (d)       |        0/12 (0%)        0/4 (0%)         0/7 (0%)         0/5 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              623              545             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.064          P<0.001 **      | 
|POLY 3             |        P=0.005 **       (e)              (e)              (e)              P=0.103          P=0.110         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              P=0.127          P=0.166         | 
|POLY 6             |        P=0.004 **       (e)              (e)              (e)              P=0.078          P=0.085         | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.115          P=0.028 *       | 
|COCH-ARM / FISHERS |        P=0.057          (e)              (e)              (e)              P=0.168          P=0.377         | 
|ORDER RESTRICTED   |        P=0.010 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        2/51 (4%)        2/53 (4%)        2/53 (4%)        0/53 (0%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        1/42.21          2/33.25          2/38.83          2/36.89          0/23.94          0/9.33          | 
|POLY-3 PERCENT (g) |        2.4%             6.0%             5.2%             5.4%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        639              541              523              686              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.473N         P=0.376          P=0.440          P=0.368          P=0.713N         P=1.000N        | 
|POLY 3             |        P=0.320N         P=0.418          P=0.471          P=0.453          P=0.605N         P=0.697N        | 
|POLY 1.5           |        P=0.189N         P=0.439          P=0.481          P=0.470          P=0.559N         P=0.626N        | 
|POLY 6             |        P=0.505N         P=0.397          P=0.462          P=0.426          P=0.664N         P=0.735N        | 
|LOGISTIC REGRESSION|        P=0.103N         P=0.479          P=0.537          P=0.449          P=0.593N         P=0.905N        | 
|COCH-ARM / FISHERS |        P=0.052N         P=0.485          P=0.500          P=0.500          P=0.500N         P=0.445N        | 
|ORDER RESTRICTED   |        P=0.621N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        26/53 (49%)      17/51 (33%)      13/53 (25%)      6/53 (11%)       6/53 (11%)       0/66 (0%)       | 
|POLY-3 RATE (b)    |        26/46.93         17/39.21         13/40.87         6/37.78          6/25.83          0/9.33          | 
|POLY-3 PERCENT (g) |        55.4%            43.4%            31.8%            15.9%            23.2%            0.0%            | 
|TERMINAL (d)       |        14/27 (52%)      5/17 (29%)       5/24 (21%)       2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        313              328              455              604              474              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.201N         P=0.480N         P=0.048N*        P=0.005N**       P=0.288          P=0.399N        | 
|POLY 3             |        P<0.001N**       P=0.179N         P=0.018N*        P<0.001N**       P=0.008N**       P=0.038N*       | 
|POLY 1.5           |        P<0.001N**       P=0.144N         P=0.012N*        P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 6             |        P=0.005N**       P=0.216N         P=0.027N*        P<0.001N**       P=0.127N         P=0.344N        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.100N         P=0.011N*        P<0.001N**       P=0.004N**       P<0.001N**      | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.076N         P=0.008N**       P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.033N*        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        2/51 (4%)        1/53 (2%)        0/53 (0%)        0/53 (0%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        3/42.81          2/33.79          1/38.31          0/36.73          0/23.94          0/9.33          | 
|POLY-3 PERCENT (g) |        7.0%             5.9%             2.6%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        555              525              567              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.146N         P=0.650N         P=0.363N         P=0.182N         P=0.422N         P=0.958N        | 
|POLY 3             |        P=0.078N         P=0.606N         P=0.346N         P=0.148N         P=0.256N         P=0.486N        | 
|POLY 1.5           |        P=0.066N         P=0.579N         P=0.330N         P=0.137N         P=0.185N         P=0.306N        | 
|POLY 6             |        P=0.078N         P=0.633N         P=0.362N         P=0.168N         P=0.377N         P=0.606N        | 
|LOGISTIC REGRESSION|        P=0.017N*        P=0.473N         P=0.286N         P=0.117N         P=0.149N         P=0.377N        | 
|COCH-ARM / FISHERS |        P=0.030N*        P=0.518N         P=0.309N         P=0.121N         P=0.121N         P=0.086N        | 
|ORDER RESTRICTED   |        P=0.470N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/35 (3%)        1/45 (2%)        9/49 (18%)       9/52 (17%)       3/63 (5%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/24.05          1/31.46          9/36.50          9/28.19          3/11.22         | 
|POLY-3 PERCENT (g) |        0.0%             4.2%             3.2%             24.7%            31.9%            26.7%           | 
|TERMINAL (d)       |        0/27 (0%)        1/13 (8%)        1/20 (5%)        4/15 (27%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          726 (T)          537              450              267             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.354          P=0.440          P<0.001 **       P<0.001 **       P=0.005 **      | 
|POLY 3             |        P<0.001 **       P=0.391          P=0.443          P<0.001 **       P<0.001 **       P=0.028 *       | 
|POLY 1.5           |        P<0.001 **       P=0.399          P=0.452          P<0.001 **       P<0.001 **       P=0.047 *       | 
|POLY 6             |        P<0.001 **       P=0.383          P=0.435          P<0.001 **       P<0.001 **       P=0.020 *       | 
|LOGISTIC REGRESSION|        P=0.002 **       P=0.354          P=0.440          P<0.001 **       P=0.003 **       P=0.113         | 
|COCH-ARM / FISHERS |        P=0.163          P=0.398          P=0.459          P<0.001 **       P<0.001 **       P=0.157         | 
|ORDER RESTRICTED   |        P=0.042 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/35 (0%)        0/45 (0%)        3/49 (6%)        0/52 (0%)        3/63 (5%)       | 
|POLY-3 RATE (b)    |        1/41.89          0/24.05          0/31.46          3/35.26          0/23.55          3/11.49         | 
|POLY-3 PERCENT (g) |        2.4%             0.0%             0.0%             8.5%             0.0%             26.1%           | 
|TERMINAL (d)       |        1/27 (4%)        0/13 (0%)        0/20 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          ---              ---              651              ---              233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.646N         P=0.560N         P=0.189          P=1.000N         P=0.009 **      | 
|POLY 3             |        P=0.105          P=0.609N         P=0.557N         P=0.245          P=0.607N         P=0.072         | 
|POLY 1.5           |        P=0.122          P=0.601N         P=0.548N         P=0.256          P=0.562N         P=0.132         | 
|POLY 6             |        P=0.061          P=0.616N         P=0.564N         P=0.226          P=0.664N         P=0.048 *       | 
|LOGISTIC REGRESSION|        P=0.092          (e)              (e)              P=0.227          (e)              P=0.313         | 
|COCH-ARM / FISHERS |        P=0.197          P=0.602N         P=0.541N         P=0.280          P=0.505N         P=0.377         | 
|ORDER RESTRICTED   |        P=0.005 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        17/53 (32%)      15/51 (29%)      16/53 (30%)      10/53 (19%)      22/53 (42%)      11/66 (17%)     | 
|POLY-3 RATE (b)    |        17/45.19         15/37.47         16/42.04         10/39.05         22/34.45         11/17.92        | 
|POLY-3 PERCENT (g) |        37.6%            40.0%            38.1%            25.6%            63.9%            61.4%           | 
|TERMINAL (d)       |        10/27 (37%)      3/17 (18%)       6/24 (25%)       5/15 (33%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              364              408              541              337              226             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.298          P=0.501          P=0.431N         P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.004 **       P=0.501          P=0.572          P=0.168N         P=0.013 *        P=0.113         | 
|POLY 1.5           |        P=0.062          P=0.553          P=0.573N         P=0.138N         P=0.050          P=0.476         | 
|POLY 6             |        P<0.001 **       P=0.470          P=0.554          P=0.224N         P=0.002 **       P=0.028 *       | 
|LOGISTIC REGRESSION|        P=0.157          P=0.548N         P=0.527N         P=0.118N         P=0.077          P=0.487         | 
|COCH-ARM / FISHERS |        P=0.133N         P=0.468N         P=0.500N         P=0.090N         P=0.210          P=0.040N*       | 
|ORDER RESTRICTED   |        P=0.078          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Glands                                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          2/24.74          0/9.33          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             8.1%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              582              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       (e)              (e)              (e)              P=0.066          (e)             | 
|POLY 3             |        P=0.016 *        (e)              (e)              (e)              P=0.144          (e)             | 
|POLY 1.5           |        P=0.056          (e)              (e)              (e)              P=0.180          (e)             | 
|POLY 6             |        P=0.007 **       (e)              (e)              (e)              P=0.107          (e)             | 
|LOGISTIC REGRESSION|        P=0.092          (e)              (e)              (e)              P=0.177          (e)             | 
|COCH-ARM / FISHERS |        P=0.281          (e)              (e)              (e)              P=0.248          (e)             | 
|ORDER RESTRICTED   |        P=0.313          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/51 (4%)        1/53 (2%)        3/53 (6%)        8/53 (15%)       1/66 (2%)       | 
|POLY-3 RATE (b)    |        0/41.89          2/33.18          1/37.79          3/37.26          8/27.67          1/10.02         | 
|POLY-3 PERCENT (g) |        0.0%             6.0%             2.7%             8.1%             28.9%            10.0%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        1/24 (4%)        2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              639              726 (T)          567              397              491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.169          P=0.477          P=0.058          P<0.001 **       P=0.150         | 
|POLY 3             |        P<0.001 **       P=0.189          P=0.479          P=0.098          P<0.001 **       P=0.306         | 
|POLY 1.5           |        P=0.002 **       P=0.200          P=0.487          P=0.105          P<0.001 **       P=0.377         | 
|POLY 6             |        P<0.001 **       P=0.179          P=0.472          P=0.088          P<0.001 **       P=0.268         | 
|LOGISTIC REGRESSION|        P=0.007 **       P=0.207          P=0.477          P=0.101          P=0.003 **       P=0.549         | 
|COCH-ARM / FISHERS |        P=0.212          P=0.238          P=0.500          P=0.121          P=0.003 **       P=0.555         | 
|ORDER RESTRICTED   |        P=0.091          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       11/51 (22%)      5/53 (9%)        8/53 (15%)       16/53 (30%)      9/66 (14%)      | 
|POLY-3 RATE (b)    |        8/43.10          11/36.20         5/38.28          8/38.81          16/31.73         9/16.16         | 
|POLY-3 PERCENT (g) |        18.6%            30.4%            13.1%            20.6%            50.4%            55.7%           | 
|TERMINAL (d)       |        5/27 (19%)       2/17 (12%)       3/24 (13%)       4/15 (27%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        564              374              608              541              397              289             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.095          P=0.368N         P=0.284          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.165          P=0.355N         P=0.518          P=0.003 **       P=0.020 *       | 
|POLY 1.5           |        P=0.003 **       P=0.191          P=0.324N         P=0.548          P=0.010 *        P=0.110         | 
|POLY 6             |        P<0.001 **       P=0.152          P=0.387N         P=0.468          P<0.001 **       P=0.005 **      | 
|LOGISTIC REGRESSION|        P=0.005 **       P=0.206          P=0.347N         P=0.544          P=0.013 *        P=0.050         | 
|COCH-ARM / FISHERS |        P=0.351          P=0.274          P=0.278N         P=0.607N         P=0.052          P=0.512N        | 
|ORDER RESTRICTED   |        P=0.015 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Squamous Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        1/53 (2%)        0/53 (0%)        2/53 (4%)        1/66 (2%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          1/38.31          0/36.73          2/24.99          1/9.90          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             0.0%             8.0%             10.1%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              567              ---              565              545             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.476          (e)              P=0.113          P=0.032 *       | 
|POLY 3             |        P=0.034 *        (e)              P=0.482          (e)              P=0.145          P=0.305         | 
|POLY 1.5           |        P=0.056          (e)              P=0.488          (e)              P=0.181          P=0.376         | 
|POLY 6             |        P=0.029 *        (e)              P=0.477          (e)              P=0.108          P=0.267         | 
|LOGISTIC REGRESSION|        P=0.104          (e)              P=0.531          (e)              P=0.261          P=0.382         | 
|COCH-ARM / FISHERS |        P=0.184          (e)              P=0.500          (e)              P=0.248          P=0.555         | 
|ORDER RESTRICTED   |        P=0.196          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/53 (21%)      10/51 (20%)      20/53 (38%)      24/53 (45%)      27/53 (51%)      18/66 (27%)     | 
|POLY-3 RATE (b)    |        11/43.10         10/37.28         20/44.05         24/42.02         27/37.13         18/22.91        | 
|POLY-3 PERCENT (g) |        25.5%            26.8%            45.4%            57.1%            72.7%            78.6%           | 
|TERMINAL (d)       |        7/27 (26%)       2/17 (12%)       9/24 (38%)       10/15 (67%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        582              70               408              480              397              222             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.345          P=0.026 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.549          P=0.038 *        P=0.002 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.578          P=0.038 *        P=0.002 **       P<0.001 **       P=0.003 **      | 
|POLY 6             |        P<0.001 **       P=0.528          P=0.039 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.539N         P=0.038 *        P=0.002 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P=0.219          P=0.540N         P=0.043 *        P=0.006 **       P<0.001 **       P=0.273         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        46/53 (87%)      34/51 (67%)      43/53 (81%)      42/53 (79%)      7/53 (13%)       9/65 (14%)      | 
|POLY-3 RATE (b)    |        46/50.65         34/42.80         43/49.57         42/48.77         7/27.77          9/17.30         | 
|POLY-3 PERCENT (g) |        90.8%            79.4%            86.8%            86.1%            25.2%            52.0%           | 
|TERMINAL (d)       |        25/27 (93%)      13/17 (77%)      21/24 (88%)      13/15 (87%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              275              399              367              337              217             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.075          P=0.393          P=0.414          P=0.071          P=0.408N         P=0.014 *       | 
|POLY 3             |        P<0.001N**       P=0.081N         P=0.361N         P=0.326N         P<0.001N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001N**       P=0.046N*        P=0.350N         P=0.335N         P<0.001N**       P<0.001N**      | 
|POLY 6             |        P<0.001N**       P=0.140N         P=0.390N         P=0.332N         P<0.001N**       P=0.257N        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.052N         P=0.375N         P=0.345N         P<0.001N**       P<0.001N**      | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.013N*        P=0.299N         P=0.219N         P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        19/53 (36%)      12/51 (24%)      15/53 (28%)      19/53 (36%)      8/53 (15%)       13/65 (20%)     | 
|POLY-3 RATE (b)    |        19/44.54         12/34.68         15/39.84         19/42.00         8/27.70          13/19.19        | 
|POLY-3 PERCENT (g) |        42.7%            34.6%            37.7%            45.2%            28.9%            67.7%           | 
|TERMINAL (d)       |        13/27 (48%)      4/17 (24%)       10/24 (42%)      5/15 (33%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        313              594              455              534              523              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.511N         P=0.423N         P=0.131          P=0.020 *        P<0.001 **      | 
|POLY 3             |        P=0.269          P=0.307N         P=0.401N         P=0.490          P=0.178N         P=0.082         | 
|POLY 1.5           |        P=0.438N         P=0.243N         P=0.351N         P=0.501          P=0.064N         P=0.429         | 
|POLY 6             |        P=0.055          P=0.353N         P=0.445N         P=0.485          P=0.458N         P=0.017 *       | 
|LOGISTIC REGRESSION|        P=0.148          P=0.287N         P=0.371N         P=0.486          P=0.154N         P=0.199         | 
|COCH-ARM / FISHERS |        P=0.019N*        P=0.123N         P=0.266N         P=0.580N         P=0.012N*        P=0.043N*       | 
|ORDER RESTRICTED   |        P=0.045 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        3/53 (6%)        3/53 (6%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          3/38.45          3/38.25          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.8%             7.8%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        2/24 (8%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              504              548              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.637          (e)              P=0.103          P=0.105          (e)              (e)             | 
|POLY 3             |        P=0.596          (e)              P=0.103          P=0.102          (e)              (e)             | 
|POLY 1.5           |        P=0.396N         (e)              P=0.109          P=0.108          (e)              (e)             | 
|POLY 6             |        P=0.278          (e)              P=0.098          P=0.095          (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.196N         (e)              P=0.115          P=0.141          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.128N         (e)              P=0.121          P=0.121          (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.555          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        3/53 (6%)        3/53 (6%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/32.58          3/38.30          3/38.09          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             7.8%             7.9%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        2/24 (8%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          572              539              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.620          P=0.408          P=0.101          P=0.101          (e)              (e)             | 
|POLY 3             |        P=0.533N         P=0.450          P=0.103          P=0.102          (e)              (e)             | 
|POLY 1.5           |        P=0.311N         P=0.464          P=0.108          P=0.107          (e)              (e)             | 
|POLY 6             |        P=0.370          P=0.437          P=0.098          P=0.094          (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.242N         P=0.408          P=0.106          P=0.135          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.085N         P=0.490          P=0.121          P=0.121          (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.578          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        1/53 (2%)        0/53 (0%)        4/53 (8%)        19/65 (29%)     | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          1/38.13          0/36.73          4/25.96          19/26.29        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             0.0%             15.4%            72.3%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              632              ---              383              233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.466          (e)              P=0.006 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.481          (e)              P=0.021 *        P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.488          (e)              P=0.034 *        P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.475          (e)              P=0.011 *        P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.504          (e)              P=0.092          P=0.029 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          (e)              P=0.059          P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          0/23.94          2/11.15         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             17.9%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              294             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.183         | 
|POLY 3             |        P=0.102          (e)              (e)              (e)              (e)              P=0.094         | 
|POLY 1.5           |        P=0.043 *        (e)              (e)              (e)              (e)              P=0.135         | 
|POLY 6             |        P=0.194          (e)              (e)              (e)              (e)              P=0.076         | 
|LOGISTIC REGRESSION|        P=0.144          (e)              (e)              (e)              (e)              P=0.782         | 
|COCH-ARM / FISHERS |        P=0.019 *        (e)              (e)              (e)              (e)              P=0.301         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        5/51 (10%)       4/53 (8%)        3/53 (6%)        2/53 (4%)        6/65 (9%)       | 
|POLY-3 RATE (b)    |        1/42.38          5/33.91          4/38.31          3/37.11          2/24.78          6/14.33         | 
|POLY-3 PERCENT (g) |        2.4%             14.8%            10.4%            8.1%             8.1%             41.9%           | 
|TERMINAL (d)       |        0/27 (0%)        3/17 (18%)       3/24 (13%)       1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        582              484              567              667              555              233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.045 *        P=0.144          P=0.193          P=0.203          P<0.001 **      | 
|POLY 3             |        P=0.065          P=0.057          P=0.148          P=0.259          P=0.326          P=0.003 **      | 
|POLY 1.5           |        P=0.109          P=0.067          P=0.159          P=0.275          P=0.400          P=0.010 *       | 
|POLY 6             |        P=0.026 *        P=0.049 *        P=0.138          P=0.234          P=0.239          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.146          P=0.085          P=0.162          P=0.275          P=0.499          P=0.278         | 
|COCH-ARM / FISHERS |        P=0.320          P=0.094          P=0.181          P=0.309          P=0.500          P=0.096         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        5/51 (10%)       3/53 (6%)        5/53 (9%)        9/53 (17%)       8/65 (12%)      | 
|POLY-3 RATE (b)    |        1/41.89          5/33.91          3/37.79          5/37.54          9/29.33          8/16.01         | 
|POLY-3 PERCENT (g) |        2.4%             14.8%            7.9%             13.3%            30.7%            50.0%           | 
|TERMINAL (d)       |        1/27 (4%)        3/17 (18%)       3/24 (13%)       1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          484              726 (T)          628              349              222             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.039 *        P=0.262          P=0.038 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.059          P=0.268          P=0.077          P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.068          P=0.282          P=0.085          P=0.002 **       P=0.002 **      | 
|POLY 6             |        P<0.001 **       P=0.051          P=0.255          P=0.066          P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.009 **       P=0.070          P=0.262          P=0.066          P=0.028 *        P=0.099         | 
|COCH-ARM / FISHERS |        P=0.027 *        P=0.094          P=0.309          P=0.103          P=0.008 **       P=0.033 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        2/42.36          0/32.58          0/37.79          0/36.73          0/23.94          0/9.28          | 
|POLY-3 PERCENT (g) |        4.7%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        639              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.521N         P=0.327N         P=0.282N         P=0.310N         P=0.647N         P=1.000N        | 
|POLY 3             |        P=0.233N         P=0.299N         P=0.263N         P=0.270N         P=0.379N         P=0.565N        | 
|POLY 1.5           |        P=0.238N         P=0.281N         P=0.253N         P=0.258N         P=0.311N         P=0.424N        | 
|POLY 6             |        P=0.187N         P=0.320N         P=0.274N         P=0.291N         P=0.483N         P=0.651N        | 
|LOGISTIC REGRESSION|        P=0.307N         P=0.274N         P=0.247N         P=0.252N         P=0.378N         P=0.773N        | 
|COCH-ARM / FISHERS |        P=0.188N         P=0.257N         P=0.248N         P=0.248N         P=0.248N         P=0.200N        | 
|ORDER RESTRICTED   |        P=0.414N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        8/53 (15%)       39/53 (74%)      49/53 (92%)      43/65 (66%)     | 
|POLY-3 RATE (b)    |        0/41.89          1/32.58          8/38.89          39/44.58         49/49.61         43/44.52        | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             20.6%            87.5%            98.8%            96.6%           | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        4/24 (17%)       15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          572              534              267              203             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.408          P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.450          P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.464          P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.437          P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.408          P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.490          P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/51 (4%)        2/53 (4%)        21/53 (40%)      14/53 (26%)      4/65 (6%)       | 
|POLY-3 RATE (b)    |        0/41.89          2/32.58          2/37.79          21/39.86         14/31.26         4/12.01         | 
|POLY-3 PERCENT (g) |        0.0%             6.1%             5.3%             52.7%            44.8%            33.3%           | 
|TERMINAL (d)       |        0/27 (0%)        2/17 (12%)       2/24 (8%)        7/15 (47%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          726 (T)          567              447              329             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.143          P=0.212          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.185          P=0.214          P<0.001 **       P<0.001 **       P=0.009 **      | 
|POLY 1.5           |        P<0.001 **       P=0.199          P=0.223          P<0.001 **       P<0.001 **       P=0.018 *       | 
|POLY 6             |        P<0.001 **       P=0.173          P=0.206          P<0.001 **       P<0.001 **       P=0.006 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.143          P=0.212          P<0.001 **       P<0.001 **       P=0.016 *       | 
|COCH-ARM / FISHERS |        P=0.206          P=0.238          P=0.248          P<0.001 **       P<0.001 **       P=0.088         | 
|ORDER RESTRICTED   |        P=0.007 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        1/53 (2%)        3/53 (6%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          1/36.73          3/25.31          0/9.28          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.7%             11.9%            0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              726 (T)          447              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.383          P=0.021 *        (e)             | 
|POLY 3             |        P=0.004 **       (e)              (e)              P=0.474          P=0.055          (e)             | 
|POLY 1.5           |        P=0.028 *        (e)              (e)              P=0.483          P=0.077          (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.459          P=0.034 *        (e)             | 
|LOGISTIC REGRESSION|        P=0.060          (e)              (e)              P=0.383          P=0.117          (e)             | 
|COCH-ARM / FISHERS |        P=0.283          (e)              (e)              P=0.500          P=0.121          (e)             | 
|ORDER RESTRICTED   |        P=0.290          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        23/53 (43%)      13/51 (25%)      19/52 (37%)      7/53 (13%)       0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        23/44.91         13/34.62         19/40.23         7/38.05          0/23.94          0/9.27          | 
|POLY-3 PERCENT (g) |        51.2%            37.6%            47.2%            18.4%            0.0%             0.0%            | 
|TERMINAL (d)       |        15/27 (56%)      6/17 (35%)       13/24 (54%)      3/15 (20%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        564              611              548              537              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012N*        P=0.364N         P=0.491N         P=0.030N*        P=0.099N         P=0.778N        | 
|POLY 3             |        P<0.001N**       P=0.156N         P=0.439N         P<0.001N**       P<0.001N**       P=0.050N        | 
|POLY 1.5           |        P<0.001N**       P=0.105N         P=0.382N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|POLY 6             |        P<0.001N**       P=0.219N         P=0.507N         P=0.003N**       P=0.002N**       P=0.356N        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.171N         P=0.443N         P=0.002N**       P<0.001N**       P=0.067N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.043N*        P=0.302N         P<0.001N**       P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.041N*        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        1/51 (2%)        0/52 (0%)        5/53 (9%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        2/41.89          1/32.58          0/37.62          5/37.69          0/23.94          0/9.27          | 
|POLY-3 PERCENT (g) |        4.8%             3.1%             0.0%             13.3%            0.0%             0.0%            | 
|TERMINAL (d)       |        2/27 (7%)        1/17 (6%)        0/24 (0%)        2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          726 (T)          ---              594              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.291          P=0.661N         P=0.264N         P=0.084          P=1.000N         P=1.000N        | 
|POLY 3             |        P=0.590N         P=0.586N         P=0.261N         P=0.173          P=0.377N         P=0.563N        | 
|POLY 1.5           |        P=0.330N         P=0.563N         P=0.254N         P=0.187          P=0.310N         P=0.423N        | 
|POLY 6             |        P=0.261          P=0.610N         P=0.269N         P=0.153          P=0.478N         P=0.650N        | 
|LOGISTIC REGRESSION|        P=0.649N         P=0.661N         (e)              P=0.155          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.080N         P=0.515N         P=0.252N         P=0.219          P=0.248N         P=0.200N        | 
|ORDER RESTRICTED   |        P=0.599N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/53 (21%)      14/51 (27%)      19/52 (37%)      18/53 (34%)      4/53 (8%)        1/65 (2%)       | 
|POLY-3 RATE (b)    |        11/43.08         14/34.98         19/41.75         18/39.76         4/25.18          1/10.02         | 
|POLY-3 PERCENT (g) |        25.5%            40.0%            45.5%            45.3%            15.9%            10.0%           | 
|TERMINAL (d)       |        6/27 (22%)       7/17 (41%)       8/24 (33%)       7/15 (47%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        564              525              471              390              520              456             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.033 *        P=0.059          P=0.041 *        P=0.007 **       P=0.043 *        P=0.289         | 
|POLY 3             |        P=0.087N         P=0.127          P=0.040 *        P=0.043 *        P=0.275N         P=0.338N        | 
|POLY 1.5           |        P=0.002N**       P=0.167          P=0.043 *        P=0.057          P=0.136N         P=0.074N        | 
|POLY 6             |        P=0.476          P=0.098          P=0.040 *        P=0.027 *        P=0.545N         P=0.597         | 
|LOGISTIC REGRESSION|        P=0.041N*        P=0.105          P=0.036 *        P=0.037 *        P=0.572N         P=0.625N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.285          P=0.057          P=0.095          P=0.046N*        P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.238N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        0/53 (0%)        2/53 (4%)        1/53 (2%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/32.58          0/37.79          2/36.73          1/24.34          0/9.33          | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             0.0%             5.4%             4.1%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        1/17 (6%)        0/24 (0%)        2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              726 (T)          ---              726 (T)          611              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.015 *        P=0.408          (e)              P=0.120          P=0.313          (e)             | 
|POLY 3             |        P=0.238          P=0.450          (e)              P=0.209          P=0.398          (e)             | 
|POLY 1.5           |        P=0.443          P=0.464          (e)              P=0.219          P=0.442          (e)             | 
|POLY 6             |        P=0.089          P=0.437          (e)              P=0.193          P=0.342          (e)             | 
|LOGISTIC REGRESSION|        P=0.151          P=0.408          (e)              P=0.120          P=0.471          (e)             | 
|COCH-ARM / FISHERS |        P=0.423N         P=0.490          (e)              P=0.248          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.572          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 60      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        49/53 (92%)      44/51 (86%)      49/53 (92%)      52/53 (98%)      50/53 (94%)      43/65 (66%)     | 
|POLY-3 RATE (b)    |        49/51.71         44/45.96         49/50.62         52/52.55         50/50.38         43/45.37        | 
|POLY-3 PERCENT (g) |        94.8%            95.7%            96.8%            99.0%            99.3%            94.8%           | 
|TERMINAL (d)       |        26/27 (96%)      17/17 (100%)     23/24 (96%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              70               408              41               267              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.060          P=0.235          P=0.006 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.479          P=0.621          P=0.491          P=0.217          P=0.185          P=0.730         | 
|POLY 1.5           |        P=0.101N         P=0.592N         P=0.485          P=0.196          P=0.239          P=0.144N        | 
|POLY 6             |        P=0.150          P=0.510          P=0.553          P=0.267          P=0.215          P=0.396         | 
|LOGISTIC REGRESSION|        P=0.226N         P=0.474N         P=0.527          P=0.167          P=0.195          P=0.337N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.241N         P=0.642N         P=0.181          P=0.500          P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.229          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        52/53 (98%)      50/51 (98%)      52/53 (98%)      50/53 (94%)      50/53 (94%)      59/65 (91%)     | 
|POLY-3 RATE (b)    |        52/53.00         50/50.86         52/52.23         50/51.80         50/51.92         59/59.63        | 
|POLY-3 PERCENT (g) |        98.1%            98.3%            99.6%            96.5%            96.3%            99.0%           | 
|TERMINAL (d)       |        26/27 (96%)      17/17 (100%)     24/24 (100%)     15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              70               63               41               166              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.025 *        P=0.231          P=0.032 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P=0.564N         P=0.752          P=0.591          P=0.547N         P=0.513N         P=0.693         | 
|POLY 1.5           |        P=0.265N         P=0.761          P=0.668          P=0.422N         P=0.406N         P=0.619N        | 
|POLY 6             |        P=0.455          P=0.734          P=0.524          P=0.748N         P=0.698N         P=0.517         | 
|LOGISTIC REGRESSION|        P=0.047N*        P=0.684N         P=0.740          P=0.301N         P=0.109N         P=0.397N        | 
|COCH-ARM / FISHERS |        P=0.014N*        P=0.743N         P=0.752N         P=0.309N         P=0.309N         P=0.096N        | 
|ORDER RESTRICTED   |        P=0.490N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 61      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        5/51 (10%)       2/53 (4%)        5/53 (9%)        3/53 (6%)        9/65 (14%)      | 
|POLY-3 RATE (b)    |        4/43.27          5/35.74          2/39.13          5/38.68          3/26.31          9/17.28         | 
|POLY-3 PERCENT (g) |        9.3%             14.0%            5.1%             12.9%            11.4%            52.1%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        564              275              399              390              313              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.332          P=0.406N         P=0.378          P=0.461          P<0.001 **      | 
|POLY 3             |        P=0.009 **       P=0.381          P=0.384N         P=0.429          P=0.545          P=0.002 **      | 
|POLY 1.5           |        P=0.022 *        P=0.411          P=0.365N         P=0.455          P=0.643N         P=0.015 *       | 
|POLY 6             |        P=0.002 **       P=0.348          P=0.406N         P=0.387          P=0.376          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.399N         P=0.642          P=0.279N         P=0.539          P=0.288N         P=0.682         | 
|COCH-ARM / FISHERS |        P=0.119          P=0.475          P=0.339N         P=0.500          P=0.500N         P=0.216         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Red Pulp                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          1/24.80          2/11.23         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             4.0%             17.8%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              373              209             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.009 **       (e)              (e)              (e)              P=0.492          P=0.269         | 
|POLY 3             |        P=0.021 *        (e)              (e)              (e)              P=0.401          P=0.094         | 
|POLY 1.5           |        P=0.014 *        (e)              (e)              (e)              P=0.445          P=0.136         | 
|POLY 6             |        P=0.037 *        (e)              (e)              (e)              P=0.345          P=0.076         | 
|LOGISTIC REGRESSION|        P=0.195          (e)              (e)              (e)              P=0.712          P=0.945         | 
|COCH-ARM / FISHERS |        P=0.019 *        (e)              (e)              (e)              P=0.500          P=0.301         | 
|ORDER RESTRICTED   |        P=0.004 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 62      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        2/53 (4%)        1/53 (2%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          2/37.16          1/24.14          0/9.25          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.4%             4.1%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              653              672              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.013 *        (e)              (e)              P=0.182          P=0.196          (e)             | 
|POLY 3             |        P=0.120          (e)              (e)              P=0.211          P=0.397          (e)             | 
|POLY 1.5           |        P=0.292          (e)              (e)              P=0.220          P=0.442          (e)             | 
|POLY 6             |        P=0.031 *        (e)              (e)              P=0.198          P=0.340          (e)             | 
|LOGISTIC REGRESSION|        P=0.188          (e)              (e)              P=0.215          P=0.303          (e)             | 
|COCH-ARM / FISHERS |        P=0.607N         (e)              (e)              P=0.248          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.530          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        1/51 (2%)        3/53 (6%)        11/53 (21%)      4/53 (8%)        9/65 (14%)      | 
|POLY-3 RATE (b)    |        4/41.89          1/32.86          3/38.97          11/39.95         4/26.09          9/16.84         | 
|POLY-3 PERCENT (g) |        9.6%             3.0%             7.7%             27.5%            15.3%            53.4%           | 
|TERMINAL (d)       |        4/27 (15%)       0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          651              548              552              349              217             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.332N         P=0.562N         P=0.014 *        P=0.006 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.260N         P=0.540N         P=0.031 *        P=0.375          P=0.002 **      | 
|POLY 1.5           |        P=0.005 **       P=0.237N         P=0.527N         P=0.034 *        P=0.497          P=0.015 *       | 
|POLY 6             |        P<0.001 **       P=0.282N         P=0.548N         P=0.029 *        P=0.225          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.047 *        P=0.299N         P=0.541N         P=0.031 *        P=0.515          P=0.198         | 
|COCH-ARM / FISHERS |        P=0.095          P=0.194N         P=0.500N         P=0.046 *        P=0.642N         P=0.216         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 63      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/51 (0%)        2/53 (4%)        4/53 (8%)        0/53 (0%)        1/65 (2%)       | 
|POLY-3 RATE (b)    |        2/41.89          0/32.58          2/38.88          4/37.44          0/23.94          1/9.95          | 
|POLY-3 PERCENT (g) |        4.8%             0.0%             5.1%             10.7%            0.0%             10.1%           | 
|TERMINAL (d)       |        2/27 (7%)        0/17 (0%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          ---              548              651              ---              482             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.056          P=0.344N         P=0.650          P=0.177          P=1.000N         P=0.186         | 
|POLY 3             |        P=0.548          P=0.296N         P=0.668          P=0.285          P=0.377N         P=0.529         | 
|POLY 1.5           |        P=0.471N         P=0.280N         P=0.676          P=0.302          P=0.310N         P=0.699         | 
|POLY 6             |        P=0.313          P=0.314N         P=0.661          P=0.260          P=0.478N         P=0.415         | 
|LOGISTIC REGRESSION|        P=0.597          (e)              P=0.696          P=0.248          (e)              P=0.554         | 
|COCH-ARM / FISHERS |        P=0.204N         P=0.257N         P=0.691N         P=0.339          P=0.248N         P=0.423N        | 
|ORDER RESTRICTED   |        P=0.500          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        1/53 (2%)        0/53 (0%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          1/37.60          0/23.94          2/11.13         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.7%             0.0%             18.0%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              367              ---              267             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.027 *        (e)              (e)              P=0.500          (e)              P=0.205         | 
|POLY 3             |        P=0.102          (e)              (e)              P=0.478          (e)              P=0.094         | 
|POLY 1.5           |        P=0.075          (e)              (e)              P=0.486          (e)              P=0.135         | 
|POLY 6             |        P=0.114          (e)              (e)              P=0.465          (e)              P=0.076         | 
|LOGISTIC REGRESSION|        P=0.358          (e)              (e)              P=0.661          (e)              P=0.817         | 
|COCH-ARM / FISHERS |        P=0.070          (e)              (e)              P=0.500          (e)              P=0.301         | 
|ORDER RESTRICTED   |        P=0.004 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 64      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/51 (0%)        1/53 (2%)        1/53 (2%)        0/53 (0%)        1/65 (2%)       | 
|POLY-3 RATE (b)    |        2/41.89          0/32.58          1/38.31          1/37.01          0/23.94          1/9.95          | 
|POLY-3 PERCENT (g) |        4.8%             0.0%             2.6%             2.7%             0.0%             10.1%           | 
|TERMINAL (d)       |        2/27 (7%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          ---              567              653              ---              482             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.099          P=0.344N         P=0.541N         P=0.648N         P=1.000N         P=0.186         | 
|POLY 3             |        P=0.524N         P=0.296N         P=0.531N         P=0.543N         P=0.377N         P=0.529         | 
|POLY 1.5           |        P=0.511N         P=0.280N         P=0.520N         P=0.528N         P=0.310N         P=0.699         | 
|POLY 6             |        P=0.522N         P=0.314N         P=0.541N         P=0.567N         P=0.478N         P=0.415         | 
|LOGISTIC REGRESSION|        P=0.549          (e)              P=0.525N         P=0.583N         (e)              P=0.554         | 
|COCH-ARM / FISHERS |        P=0.389N         P=0.257N         P=0.500N         P=0.500N         P=0.248N         P=0.423N        | 
|ORDER RESTRICTED   |        P=0.367          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Artery                                                                                                     | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        2/53 (4%)        0/53 (0%)        0/65 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          2/37.24          0/23.94          0/9.25          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.4%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              602              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.519          (e)              (e)              P=0.181          (e)              (e)             | 
|POLY 3             |        P=0.446          (e)              (e)              P=0.211          (e)              (e)             | 
|POLY 1.5           |        P=0.641          (e)              (e)              P=0.220          (e)              (e)             | 
|POLY 6             |        P=0.180          (e)              (e)              P=0.198          (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.715          (e)              (e)              P=0.225          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.441N         (e)              (e)              P=0.248          (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.590          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 65      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        2/65 (3%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/33.46          0/37.79          0/36.73          1/24.70          2/10.92         | 
|POLY-3 PERCENT (g) |        0.0%             3.0%             0.0%             0.0%             4.1%             18.3%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              364              ---              ---              447              237             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012 *        P=0.483          (e)              (e)              P=0.475          P=0.094         | 
|POLY 3             |        P=0.074          P=0.455          (e)              (e)              P=0.401          P=0.093         | 
|POLY 1.5           |        P=0.058          P=0.467          (e)              (e)              P=0.444          P=0.134         | 
|POLY 6             |        P=0.103          P=0.444          (e)              (e)              P=0.344          P=0.076         | 
|LOGISTIC REGRESSION|        P=0.354          P=0.690          (e)              (e)              P=0.663          P=0.580         | 
|COCH-ARM / FISHERS |        P=0.083          P=0.490          (e)              (e)              P=0.500          P=0.301         | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        3/65 (5%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.73          1/24.70          3/12.13         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             4.1%             24.7%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              447              233             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.475          P=0.129         | 
|POLY 3             |        P=0.007 **       (e)              (e)              (e)              P=0.401          P=0.030 *       | 
|POLY 1.5           |        P=0.003 **       (e)              (e)              (e)              P=0.444          P=0.051         | 
|POLY 6             |        P=0.014 *        (e)              (e)              (e)              P=0.344          P=0.022 *       | 
|LOGISTIC REGRESSION|        P=0.101          (e)              (e)              (e)              P=0.663          P=0.814         | 
|COCH-ARM / FISHERS |        P=0.004 **       (e)              (e)              (e)              P=0.500          P=0.164         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 66      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        12/53 (23%)      6/51 (12%)       6/53 (11%)       1/53 (2%)        6/53 (11%)       5/65 (8%)       | 
|POLY-3 RATE (b)    |        12/45.97         6/34.71          6/41.20          1/36.81          6/26.38          5/13.58         | 
|POLY-3 PERCENT (g) |        26.1%            17.3%            14.6%            2.7%             22.7%            36.8%           | 
|TERMINAL (d)       |        3/27 (11%)       2/17 (12%)       0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        313              443              443              707              447              267             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       P=0.313N         P=0.180N         P=0.010N*        P=0.250          P=0.053         | 
|POLY 3             |        P=0.463          P=0.252N         P=0.142N         P=0.004N**       P=0.486N         P=0.378         | 
|POLY 1.5           |        P=0.471N         P=0.199N         P=0.124N         P=0.002N**       P=0.279N         P=0.434N        | 
|POLY 6             |        P=0.343          P=0.315N         P=0.164N         P=0.007N**       P=0.441          P=0.170         | 
|LOGISTIC REGRESSION|        P=0.094N         P=0.090N         P=0.055N         P<0.001N**       P=0.113N         P=0.033N*       | 
|COCH-ARM / FISHERS |        P=0.102N         P=0.113N         P=0.098N         P<0.001N**       P=0.098N         P=0.021N*       | 
|ORDER RESTRICTED   |        P=0.174          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/53 (75%)      44/51 (86%)      44/51 (86%)      49/51 (96%)      50/51 (98%)      57/59 (97%)     | 
|POLY-3 RATE (b)    |        40/48.92         44/46.56         44/48.76         49/49.00         50/50.68         57/57.15        | 
|POLY-3 PERCENT (g) |        81.8%            94.5%            90.3%            100.0%           98.7%            99.7%           | 
|TERMINAL (d)       |        23/27 (85%)      17/17 (100%)     18/22 (82%)      15/15 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              275              399              261              166              91              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.003 **       P=0.079          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.036 *        P=0.162          P<0.001 **       P=0.002 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.037 *        P=0.121          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.047 *        P=0.248          P=0.002 **       P=0.004 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.029 *        P=0.086          P<0.001 **       P<0.001 **       P=0.002 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.125          P=0.125          P=0.003 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 67      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        2/51 (4%)        0/51 (0%)        0/51 (0%)        0/59 (0%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          2/37.17          0/35.75          0/22.78          0/8.50          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.4%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/22 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              399              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.430N         (e)              P=0.234          (e)              (e)              (e)             | 
|POLY 3             |        P=0.472N         (e)              P=0.211          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.405N         (e)              P=0.217          (e)              (e)              (e)             | 
|POLY 6             |        P=0.532N         (e)              P=0.204          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.145N         (e)              P=0.300          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.264N         (e)              P=0.238          (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.689          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/53 (13%)       11/51 (22%)      13/53 (25%)      10/52 (19%)      15/52 (29%)      3/66 (5%)       | 
|POLY-3 RATE (b)    |        7/43.53          11/34.81         13/40.75         10/39.26         15/31.04         3/11.81         | 
|POLY-3 PERCENT (g) |        16.1%            31.6%            31.9%            25.5%            48.3%            25.4%           | 
|TERMINAL (d)       |        3/27 (11%)       6/17 (35%)       6/24 (25%)       3/15 (20%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        555              534              455              548              373              321             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.051          P=0.073          P=0.120          P<0.001 **       P=0.034 *       | 
|POLY 3             |        P=0.016 *        P=0.086          P=0.070          P=0.215          P=0.002 **       P=0.415         | 
|POLY 1.5           |        P=0.213          P=0.113          P=0.082          P=0.235          P=0.009 **       P=0.528N        | 
|POLY 6             |        P<0.001 **       P=0.066          P=0.060          P=0.183          P<0.001 **       P=0.237         | 
|LOGISTIC REGRESSION|        P=0.420          P=0.110          P=0.092          P=0.261          P=0.027 *        P=0.512N        | 
|COCH-ARM / FISHERS |        P=0.032N*        P=0.193          P=0.107          P=0.284          P=0.041 *        P=0.087N        | 
|ORDER RESTRICTED   |        P=0.211          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 68      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        0/52 (0%)        2/52 (4%)        1/66 (2%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          0/36.44          2/24.73          1/9.99          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             8.1%             10.0%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        0/15 (0%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              582              504             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.066          P=0.128         | 
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              P=0.143          P=0.306         | 
|POLY 1.5           |        P=0.016 *        (e)              (e)              (e)              P=0.179          P=0.377         | 
|POLY 6             |        P=0.009 **       (e)              (e)              (e)              P=0.106          P=0.268         | 
|LOGISTIC REGRESSION|        P=0.016 *        (e)              (e)              (e)              P=0.180          P=0.511         | 
|COCH-ARM / FISHERS |        P=0.072          (e)              (e)              (e)              P=0.243          P=0.555         | 
|ORDER RESTRICTED   |        P=0.135          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        22/53 (42%)      35/51 (69%)      34/53 (64%)      38/52 (73%)      44/52 (85%)      37/66 (56%)     | 
|POLY-3 RATE (b)    |        22/47.33         35/45.44         34/48.44         38/49.28         44/47.20         37/40.35        | 
|POLY-3 PERCENT (g) |        46.5%            77.0%            70.2%            77.1%            93.2%            91.7%           | 
|TERMINAL (d)       |        9/27 (33%)       11/17 (65%)      14/24 (58%)      11/15 (73%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              70               399              41               267              51              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P=0.017 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P=0.012 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.002 **       P=0.011 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P=0.014 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.302          P=0.009 **       P=0.022 *        P=0.002 **       P<0.001 **       P=0.137         | 
|COCH-ARM / FISHERS |        P=0.301          P=0.005 **       P=0.016 *        P<0.001 **       P<0.001 **       P=0.082         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 69      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        29/29 (100%)     26/26 (100%)     33/33 (100%)     34/34 (100%)     29/29 (100%)     25/25 (100%)    | 
|POLY-3 RATE (b)    |        29/29.00         26/26.00         33/33.00         34/34.00         29/29.00         25/25.00        | 
|POLY-3 PERCENT (g) |        100.0%           100.0%           100.0%           100.0%           100.0%           100.0%          | 
|TERMINAL (d)       |        16/16 (100%)     8/8 (100%)       20/20 (100%)     10/10 (100%)     0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        534              70               408              480              313              245             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       3/51 (6%)        2/53 (4%)        4/53 (8%)        1/52 (2%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        8/43.36          3/33.27          2/37.79          4/37.84          1/24.28          0/9.33          | 
|POLY-3 PERCENT (g) |        18.5%            9.0%             5.3%             10.6%            4.1%             0.0%            | 
|TERMINAL (d)       |        3/27 (11%)       0/17 (0%)        2/24 (8%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        362              616              726 (T)          567              548              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.535N         P=0.279N         P=0.078N         P=0.405N         P=0.629N         P=0.642N        | 
|POLY 3             |        P=0.100N         P=0.203N         P=0.070N         P=0.246N         P=0.112N         P=0.283N        | 
|POLY 1.5           |        P=0.037N*        P=0.170N         P=0.060N         P=0.222N         P=0.052N         P=0.073N        | 
|POLY 6             |        P=0.203N         P=0.237N         P=0.083N         P=0.287N         P=0.262N         P=0.503N        | 
|LOGISTIC REGRESSION|        P=0.049N*        P=0.160N         P=0.060N         P=0.203N         P=0.052N         P=0.136N        | 
|COCH-ARM / FISHERS |        P=0.003N**       P=0.113N         P=0.046N*        P=0.179N         P=0.017N*        P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.267N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 70      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        2/51 (4%)        0/53 (0%)        4/53 (8%)        1/52 (2%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        4/42.40          2/33.22          0/37.79          4/37.31          1/24.28          0/9.33          | 
|POLY-3 PERCENT (g) |        9.4%             6.0%             0.0%             10.7%            4.1%             0.0%            | 
|TERMINAL (d)       |        1/27 (4%)        0/17 (0%)        0/24 (0%)        2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        672              616              ---              636              548              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.323          P=0.528N         P=0.089N         P=0.408          P=0.590          P=1.000         | 
|POLY 3             |        P=0.463N         P=0.454N         P=0.076N         P=0.572          P=0.386N         P=0.426N        | 
|POLY 1.5           |        P=0.252N         P=0.422N         P=0.070N         P=0.597          P=0.287N         P=0.224N        | 
|POLY 6             |        P=0.465          P=0.486N         P=0.083N         P=0.529          P=0.540N         P=0.574N        | 
|LOGISTIC REGRESSION|        P=0.378N         P=0.442N         P=0.078N         P=0.549          P=0.425N         P=0.765N        | 
|COCH-ARM / FISHERS |        P=0.046N*        P=0.358N         P=0.059N         P=0.642N         P=0.187N         P=0.037N*       | 
|ORDER RESTRICTED   |        P=0.466N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Adenomyosis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/51 (2%)        0/53 (0%)        3/53 (6%)        0/53 (0%)        1/66 (2%)       | 
|POLY-3 RATE (b)    |        0/41.89          1/32.84          0/37.79          3/37.12          0/23.94          1/10.14         | 
|POLY-3 PERCENT (g) |        0.0%             3.1%             0.0%             8.1%             0.0%             9.9%            | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              659              ---              663              ---              415             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.015 *        P=0.431          (e)              P=0.059          (e)              P=0.308         | 
|POLY 3             |        P=0.302          P=0.452          (e)              P=0.098          (e)              P=0.307         | 
|POLY 1.5           |        P=0.426          P=0.464          (e)              P=0.105          (e)              P=0.378         | 
|POLY 6             |        P=0.145          P=0.440          (e)              P=0.088          (e)              P=0.268         | 
|LOGISTIC REGRESSION|        P=0.299          P=0.466          (e)              P=0.088          (e)              P=0.744         | 
|COCH-ARM / FISHERS |        P=0.551N         P=0.490          (e)              P=0.121          (e)              P=0.555         | 
|ORDER RESTRICTED   |        P=0.243          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 71      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/51 (0%)        0/53 (0%)        2/53 (4%)        0/53 (0%)        1/66 (2%)       | 
|POLY-3 RATE (b)    |        0/41.89          0/32.58          0/37.79          2/37.11          0/23.94          1/10.02         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.4%             0.0%             10.0%           | 
|TERMINAL (d)       |        0/27 (0%)        0/17 (0%)        0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              619              ---              491             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              P=0.159          (e)              P=0.150         | 
|POLY 3             |        P=0.226          (e)              (e)              P=0.211          (e)              P=0.306         | 
|POLY 1.5           |        P=0.284          (e)              (e)              P=0.220          (e)              P=0.377         | 
|POLY 6             |        P=0.130          (e)              (e)              P=0.197          (e)              P=0.268         | 
|LOGISTIC REGRESSION|        P=0.164          (e)              (e)              P=0.213          (e)              P=0.549         | 
|COCH-ARM / FISHERS |        P=0.397          (e)              (e)              P=0.248          (e)              P=0.555         | 
|ORDER RESTRICTED   |        P=0.136          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        3/51 (6%)        5/53 (9%)        7/53 (13%)       0/53 (0%)        2/66 (3%)       | 
|POLY-3 RATE (b)    |        4/41.89          3/32.77          5/39.35          7/38.64          0/23.94          2/10.47         | 
|POLY-3 PERCENT (g) |        9.6%             9.2%             12.7%            18.1%            0.0%             19.1%           | 
|TERMINAL (d)       |        4/27 (15%)       1/17 (6%)        2/24 (8%)        2/15 (13%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        726 (T)          700              523              539              ---              415             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.020 *        P=0.575          P=0.422          P=0.089          P=1.000N         P=0.006 **      | 
|POLY 3             |        P=0.385N         P=0.632N         P=0.460          P=0.212          P=0.169N         P=0.415         | 
|POLY 1.5           |        P=0.197N         P=0.597N         P=0.473          P=0.227          P=0.109N         P=0.653N        | 
|POLY 6             |        P=0.440          P=0.644          P=0.454          P=0.191          P=0.289N         P=0.274         | 
|LOGISTIC REGRESSION|        P=0.500N         P=0.604          P=0.455          P=0.202          (e)              P=0.119         | 
|COCH-ARM / FISHERS |        P=0.029N*        P=0.522N         P=0.500          P=0.263          P=0.059N         P=0.242N        | 
|ORDER RESTRICTED   |        P=0.520          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 72      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        5/51 (10%)       2/53 (4%)        5/53 (9%)        0/53 (0%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        2/42.77          5/34.59          2/38.44          5/38.80          0/23.94          0/9.33          | 
|POLY-3 PERCENT (g) |        4.7%             14.5%            5.2%             12.9%            0.0%             0.0%            | 
|TERMINAL (d)       |        1/27 (4%)        2/17 (12%)       0/24 (0%)        1/15 (7%)        0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        362              374              558              552              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.272N         P=0.122          P=0.668          P=0.140          P=0.512N         P=0.642N        | 
|POLY 3             |        P=0.248N         P=0.138          P=0.656          P=0.177          P=0.382N         P=0.565N        | 
|POLY 1.5           |        P=0.092N         P=0.156          P=0.669          P=0.188          P=0.313N         P=0.424N        | 
|POLY 6             |        P=0.542N         P=0.122          P=0.645          P=0.160          P=0.483N         P=0.651N        | 
|LOGISTIC REGRESSION|        P=0.005N**       P=0.272          P=0.657N         P=0.263          P=0.145N         P=0.191N        | 
|COCH-ARM / FISHERS |        P=0.008N**       P=0.203          P=0.691N         P=0.219          P=0.248N         P=0.196N        | 
|ORDER RESTRICTED   |        P=0.520N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        23/53 (43%)      24/51 (47%)      28/53 (53%)      24/53 (45%)      0/53 (0%)        0/66 (0%)       | 
|POLY-3 RATE (b)    |        23/44.48         24/38.40         28/45.95         24/43.93         0/23.94          0/9.33          | 
|POLY-3 PERCENT (g) |        51.7%            62.5%            60.9%            54.6%            0.0%             0.0%            | 
|TERMINAL (d)       |        16/27 (59%)      12/17 (71%)      13/24 (54%)      7/15 (47%)       0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        555              364              399              367              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.026N*        P=0.043 *        P=0.114          P=0.064          P=0.124N         P=0.848N        | 
|POLY 3             |        P<0.001N**       P=0.210          P=0.242          P=0.474          P<0.001N**       P=0.046N*       | 
|POLY 1.5           |        P<0.001N**       P=0.269          P=0.227          P=0.467          P<0.001N**       P<0.001N**      | 
|POLY 6             |        P=0.003N**       P=0.155          P=0.263          P=0.464          P=0.002N**       P=0.350N        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.172          P=0.165          P=0.383          P<0.001N**       P=0.120N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.429          P=0.218          P=0.500          P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.031N*        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 73      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        32/53 (60%)      23/51 (45%)      25/53 (47%)      30/53 (57%)      7/53 (13%)       8/66 (12%)      | 
|POLY-3 RATE (b)    |        32/46.96         23/36.64         25/45.63         30/43.41         7/26.36          8/15.68         | 
|POLY-3 PERCENT (g) |        68.2%            62.8%            54.8%            69.1%            26.6%            51.0%           | 
|TERMINAL (d)       |        21/27 (78%)      12/17 (71%)      11/24 (46%)      12/15 (80%)      0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        275              347              399              390              523              243             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.431          P=0.331N         P=0.059          P=0.187          P=0.003 **      | 
|POLY 3             |        P=0.005N**       P=0.382N         P=0.123N         P=0.555          P<0.001N**       P=0.217N        | 
|POLY 1.5           |        P<0.001N**       P=0.260N         P=0.131N         P=0.587N         P<0.001N**       P=0.003N**      | 
|POLY 6             |        P=0.224N         P=0.503N         P=0.102N         P=0.522          P=0.020N*        P=0.462         | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.302N         P=0.141N         P=0.568          P<0.001N**       P=0.077N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.086N         P=0.121N         P=0.422N         P<0.001N**       P<0.001N**      | 
|ORDER RESTRICTED   |        P=0.050N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).