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TDMS Study 96022-02 Pathology Tables

NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04
Route: GAVAGE                                                                                                     Time: 14:02:07

                                                 CORE STUDY ALL GROUPS/FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFPCBMIX

       Lock Date:  11/04/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          98           86           98           86           98           86           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           20           21           23           43           44           
    Natural Death                                      5           14            8           13           10           22           
    Dosing Accident                                                                           2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           17           24           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    53           51           53           53           53           66           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (53)         (51)         (53)         (53)         (53)         (66)         
      Leiomyoma                                                     1 (2%)       1 (2%)                                             
   Liver                                              (53)         (51)         (53)         (53)         (53)         (65)         
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Cholangiocarcinoma                                                         4 (8%)       7 (13%)      7 (13%)      5 (8%)      
      Cholangiocarcinoma, Multiple                                               1 (2%)      12 (23%)     21 (40%)      7 (11%)     
      Cholangioma                                                                             1 (2%)                                
      Hepatocellular Carcinoma                                                                             1 (2%)                   
      Hepatocellular Adenoma                           2 (4%)       1 (2%)                    2 (4%)       7 (13%)      3 (5%)      
      Hepatocellular Adenoma, Multiple                                                        2 (4%)      10 (19%)      2 (3%)      
      Hepatocholangioma                                                                       1 (2%)                    1 (2%)      
      Hepatocholangioma, Multiple                                                                          1 (2%)                   
   Oral Mucosa                                        (53)         (51)         (53)         (53)         (53)         (66)         
      Gingival, Squamous Cell Carcinoma                1 (2%)       1 (2%)       2 (4%)       4 (8%)                    1 (2%)      
   Pancreas                                           (53)         (51)         (53)         (53)         (53)         (65)         
      Carcinoma                                                                  1 (2%)                                             
      Schwannoma Malignant, Metastatic, Uterus                      1 (2%)                                                          
      Acinus, Adenoma                                                            1 (2%)                                             
   Salivary Glands                                    (53)         (51)         (53)         (52)         (52)         (66)         
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Stomach, Forestomach                               (53)         (51)         (53)         (53)         (53)         (65)         
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (53)         (51)         (53)         (53)         (53)         (65)         
      Carcinoma                                                                               1 (2%)                                
      Neuroendocrine Tumor, Malignant                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (53)         (51)         (53)         (53)         (53)         (65)         
      Schwannoma Benign                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (51)         (53)         (53)         (53)         (65)         
      Adenoma                                                                                                           1 (2%)      
      Carcinoma                                        1 (2%)                                                                       
      Subcapsular, Adenoma                                                       1 (2%)                                             
   Adrenal Medulla                                    (53)         (51)         (53)         (53)         (53)         (64)         
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          3 (6%)       3 (6%)       2 (4%)                    1 (2%)                   
   Islets, Pancreatic                                 (53)         (51)         (53)         (53)         (53)         (65)         
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (53)         (51)         (52)         (53)         (53)         (65)         
      Pars Distalis, Adenoma                          30 (57%)     11 (22%)     16 (31%)     10 (19%)                               
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (53)         (51)         (53)         (52)         (52)         (66)         
      Bilateral, C-Cell, Adenoma                       1 (2%)                    1 (2%)                                             
      Bilateral, C-Cell, Carcinoma                     1 (2%)                                                                       
      C-Cell, Adenoma                                  8 (15%)      5 (10%)      7 (13%)      8 (15%)      4 (8%)       1 (2%)      
      C-Cell, Carcinoma                                3 (6%)       2 (4%)       2 (4%)                                             
      Follicular Cell, Adenoma                                                   2 (4%)                    2 (4%)       1 (2%)      
      Follicular Cell, Carcinoma                       1 (2%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (51)         (51)         (52)         (52)         (66)         
      Carcinoma                                                                  1 (2%)                                             
   Ovary                                              (53)         (51)         (53)         (53)         (53)         (65)         
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
      Periovarian Tissue, Carcinoma, Metastatic,                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
           Pancreas                                                              1 (2%)                                             
   Uterus                                             (53)         (51)         (53)         (53)         (53)         (66)         
      Carcinoma                                        1 (2%)       1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Fibrosarcoma                                                                            1 (2%)                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                    8 (15%)      4 (8%)       6 (11%)      8 (15%)      6 (11%)      3 (5%)      
      Schwannoma Malignant                                          1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Vagina                                   1 (2%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Bilateral, Polyp Stromal                         3 (6%)       2 (4%)       1 (2%)                    1 (2%)                   
      Cervix, Schwannoma Malignant                     1 (2%)                                                                       
      Cervix, Schwannoma Malignant, Metastatic,                                                                                     
           Vagina                                                                1 (2%)                                             
   Vagina                                                                       (2)                                                 
      Schwannoma Malignant                                                       1 (50%)                                            
      Schwannoma Malignant, Metastatic, Skin                                     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (51)         (53)         (53)         (53)         (66)         
   Lymph Node                                         (28)         (16)         (16)         (25)         (20)         (45)         
      Pancreatic, Carcinoma, Metastatic, Stomach,                                                                                   
           Glandular                                                                          1 (4%)                                
   Lymph Node, Mandibular                             (53)         (51)         (53)         (52)         (52)         (66)         
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Spleen                                             (53)         (51)         (53)         (53)         (53)         (65)         
   Thymus                                             (53)         (51)         (51)         (51)         (51)         (59)         
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (51)         (53)         (53)         (53)         (66)         
      Adenolipoma                                                                             1 (2%)                                
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Carcinoma                                        4 (8%)       1 (2%)       3 (6%)                                             
      Carcinoma, Multiple                              1 (2%)                    1 (2%)                                             
      Fibroadenoma                                    27 (51%)     23 (45%)     21 (40%)     14 (26%)      4 (8%)       6 (9%)      
      Fibroadenoma, Multiple                          15 (28%)     15 (29%)     15 (28%)      3 (6%)                                
   Skin                                               (53)         (51)         (53)         (53)         (53)         (66)         
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Basal Cell Adenoma                               1 (2%)                                                                       
      Fibroma                                          1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Fibrosarcoma                                                               1 (2%)                                             
      Schwannoma Malignant                                          1 (2%)       1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
      Carcinoma, Metastatic, Pancreas                                            1 (100%)                                           
      Schwannoma Malignant, Metastatic, Uterus                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (51)         (53)         (53)         (53)         (66)         
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Oral Mucosa                                         1 (2%)                                             
      Medulloblastoma Mal                              1 (2%)                                                                       
      Cranial Nerve, Schwannoma Malignant                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (51)         (53)         (53)         (53)         (66)         
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Cystic Keratinizing Epithelioma                                                         6 (11%)      1 (2%)       6 (9%)      
      Cystic Keratinizing Epithelioma, Multiple                                              14 (26%)     48 (91%)     35 (53%)     
   Nose                                               (53)         (51)         (53)         (53)         (53)         (66)         
      Schwannoma Malignant, Metastatic, Brain                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (53)         (51)         (53)         (53)         (53)         (66)         
      Carcinoma, Metastatic, Oral Mucosa                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (51)         (53)         (53)         (53)         (65)         
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Papilloma                                                     1 (2%)                                                          
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (53)         (51)         (53)         (53)         (52)         (66)         
      Schwannoma Malignant, Metastatic, Uterus                      1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(53)        *(51)        *(53)        *(53)        *(53)        *(66)         
      Adenolipoma                                                                             1 (2%)                                
      Leukemia Granulocytic                                                                                             1 (2%)      
      Leukemia Mononuclear                             1 (2%)                                                                       
      Lymphoma Malignant                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53          47          51          42          51          45               
     Total Primary Neoplasms                          126          80          96         102         115          73               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 53          43          47          40          51          45               
     Total Benign Neoplasms                           107          68          76          74          85          59               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          12          18          21          28          14               
     Total Malignant Neoplasms                         19          12          20          27          30          14               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           5           6           1                                       
     Total Metastatic Neoplasm                          1           8          13           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                4000 NG/                                                                         
                                                   500UG ST                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50                                                                            
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28                                                                            
    Natural Death                                     12                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50                                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)                                                                          
   Intestine Large, Cecum                             (50)                                                                          
   Intestine Small, Duodenum                          (50)                                                                          
   Intestine Small, Jejunum                           (50)                                                                          
   Intestine Small, Ileum                             (50)                                                                          
   Liver                                              (50)                                                                          
      Cholangiocarcinoma                               7 (14%)                                                                      
      Cholangiocarcinoma, Multiple                    12 (24%)                                                                      
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Hepatocholangioma                                1 (2%)                                                                       
   Oral Mucosa                                        (50)                                                                          
      Gingival, Squamous Cell Carcinoma                1 (2%)                                                                       
   Pancreas                                           (50)                                                                          
   Salivary Glands                                    (49)                                                                          
   Stomach, Forestomach                               (50)                                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)                                                                          
   Heart                                              (50)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                4000 NG/                                                                         
                                                   500UG ST                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (49)                                                                          
      C-Cell, Adenoma                                  4 (8%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (50)                                                                          
      Polyp Stromal                                    7 (14%)                                                                      
      Bilateral, Polyp Stromal                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (22)                                                                          
   Lymph Node, Mandibular                             (49)                                                                          
   Lymph Node, Mesenteric                             (50)                                                                          
   Spleen                                             (50)                                                                          
   Thymus                                             (46)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                                                          
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                    11 (22%)                                                                      
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (50)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                4000 NG/                                                                         
                                                   500UG ST                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                                                                          
      Cranial Nerve, Squamous Cell Carcinoma,                                                                                       
          Metastatic, Oral Mucosa                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                                                          
      Cystic Keratinizing Epithelioma                  7 (14%)                                                                      
      Cystic Keratinizing Epithelioma, Multiple        5 (10%)                                                                      
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)                                                                          
   Urinary Bladder                                    (50)                                                                          
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)                                                                          
      Lymphoma Malignant                               1 (2%)                                                                       
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04  
Route: GAVAGE                                                                                                     Time: 14:02:07  
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         SPRAGUE-DAWLEY RATS FEMALE                4000 NG/                                                                         
                                                   500UG ST                                                                         
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36                                                                           
     Total Primary Neoplasms                           61                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28                                                                           
     Total Benign Neoplasms                            39                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20                                                                           
     Total Malignant Neoplasms                         22                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          1                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
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