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TDMS Study 96022-02 Pathology Tables

NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31

                                                         FINAL #1 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFPCBMIX

       Lock Date:  11/04/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           86           98           86           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           20           21           23           43           44           
    Natural Death                                      5           14            8           13           10           22           
    Dosing Accident                                                                           2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           17           24           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    53           51           53           53           53           66           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (51)         (53)         (53)         (53)         (66)         
      Degeneration                                                  1 [3.0]                                                         
      Muscularis, Inflammation                         3 [2.0]                   2 [2.0]      3 [1.3]      3 [1.7]      2 [2.5]     
   Intestine Large, Colon                             (53)         (51)         (53)         (53)         (52)         (65)         
      Parasite Metazoan                                2            1                                                   2           
      Artery, Inflammation, Chronic Active                                       1 [2.0]      1 [3.0]                               
   Intestine Large, Rectum                            (52)         (51)         (53)         (53)         (52)         (66)         
      Hyperplasia, Cystic                                                                                               1 [2.0]     
      Parasite Metazoan                                3            2            2            2            1                        
      Artery, Inflammation, Chronic Active                          1 [3.0]      1 [3.0]      3 [3.0]      1 [3.0]                  
   Intestine Large, Cecum                             (53)         (51)         (53)         (53)         (52)         (65)         
      Edema                                                                                                             2 [2.0]     
      Inflammation                                                                                                      2 [2.0]     
      Artery, Inflammation, Chronic Active                                                    2 [3.0]                               
   Intestine Small, Duodenum                          (53)         (51)         (53)         (53)         (53)         (65)         
      Dilatation                                                                              1 [3.0]                               
      Erosion                                                                                 1 [2.0]                               
      Hyperplasia                                                                             1 [3.0]                               
      Artery, Inflammation, Chronic Active                                       1 [2.0]                                            
   Intestine Small, Ileum                             (53)         (51)         (53)         (53)         (52)         (65)         
      Parasite Metazoan                                                                                    1                        
   Liver                                              (53)         (51)         (53)         (53)         (53)         (65)         
      Angiectasis                                                   1 [2.0]      2 [1.0]      1 [2.0]      3 [2.0]      2 [2.5]     
      Basophilic Focus                                14            8            6            5            4                        
      Basophilic Focus, Multiple                      13            8            4            3                                     
      Cholangiofibrosis                                1 [3.0]      2 [1.0]      3 [1.0]     21 [2.2]     42 [3.4]     29 [3.2]     
      Clear Cell Focus                                 4            1                                                               
      Clear Cell Focus, Multiple                       1                                      1                                     
      Degeneration, Cystic                                                       1 [1.0]                   1 [2.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Eosinophilic Focus                               5            5           11            1            2                        
      Eosinophilic Focus, Multiple                     5           16           12           14            4           10           
      Fatty Change, Diffuse                            3 [1.3]     14 [1.0]     27 [1.2]     45 [1.5]     49 [1.7]     56 [1.8]     
      Fatty Change, Focal                             10 [1.3]     10 [1.4]      6 [1.7]      1 [2.0]     10 [2.6]      6 [2.2]     
      Hematopoietic Cell Proliferation                27 [1.1]     27 [1.0]     30 [1.0]     32 [1.0]     22 [1.1]     11 [1.0]     
      Hepatodiaphragmatic Nodule                       2            2                         2                                     
      Hyperplasia, Nodular                                                      10           45           50           61           
      Inflammation                                    49 [1.0]     47 [1.2]     50 [1.1]     52 [1.4]     51 [1.2]     64 [1.4]     
      Metaplasia                                                                                           4 [1.0]      4 [2.0]     
      Mineralization                                                                                                    1 [2.0]     
      Mixed Cell Focus                                 5            5            4                         1            3           
      Mixed Cell Focus, Multiple                      33           23           28           16            1                        
      Necrosis                                         3 [1.3]     13 [2.2]      6 [2.0]     26 [2.0]     17 [2.4]     27 [2.2]     
      Pigmentation                                     5 [1.0]     18 [1.4]     38 [1.6]     52 [2.1]     53 [2.0]     60 [2.0]     
      Thrombosis                                                                                                        1 [2.0]     
      Toxic Hepatopathy                                             8 [1.1]     32 [1.2]     51 [2.6]     52 [3.5]     64 [3.6]     
      Artery, Inflammation                                          1 [1.0]                   1 [3.0]                               
      Bile Duct, Cyst                                  4 [2.3]      3 [3.0]      3 [2.3]     14 [2.1]     25 [2.2]     14 [1.9]     
      Bile Duct, Dilatation                                                                                             1 [2.0]     
      Bile Duct, Fibrosis                              6 [1.7]      2 [1.0]      3 [1.3]     10 [1.7]      3 [2.0]      4 [1.5]     
      Bile Duct, Hyperplasia                           5 [1.0]      5 [1.2]      7 [1.9]     46 [1.8]     52 [1.9]     60 [2.4]     
      Centrilobular, Degeneration                      2 [2.5]      3 [2.0]      8 [1.9]      8 [2.0]      3 [2.3]      8 [1.9]     
      Centrilobular, Fibrosis                                                    7 [1.0]     36 [1.6]     52 [1.9]     57 [2.1]     
      Hepatocyte, Glandular Structures                                                        1 [1.0]      5 [1.2]     25 [2.2]     
      Hepatocyte, Hypertrophy                                      16 [1.1]     22 [1.4]     47 [2.6]     52 [3.2]     65 [3.5]     
      Hepatocyte, Multinucleated                                    9 [1.3]     21 [1.2]     48 [1.8]     52 [1.9]     48 [1.7]     
      Oval Cell, Hyperplasia                           4 [1.0]      4 [1.0]     23 [1.2]     49 [2.1]     52 [3.0]     62 [3.0]     
      Portal, Fibrosis                                                           2 [1.0]     37 [1.8]     52 [2.7]     58 [2.9]     
      Serosa, Inflammation                                          2 [2.5]                                                         
   Mesentery                                          (53)         (35)         (45)         (49)         (52)         (63)         
      Inflammation                                                  1 [3.0]                                                         
      Necrosis                                                                   1 [3.0]      1 [3.0]                               
      Artery, Inflammation, Chronic Active                          1 [3.0]      1 [4.0]      9 [2.7]      9 [2.1]      3 [1.7]     
      Fat, Necrosis                                    1 [3.0]                                3 [2.3]                   3 [2.7]     
   Oral Mucosa                                        (53)         (51)         (53)         (53)         (53)         (66)         
      Cyst                                                                                                              1 [2.0]     
      Gingival, Hyperplasia, Squamous                 11 [1.1]     10 [1.2]     20 [1.4]     24 [1.8]     27 [1.7]     18 [1.6]     
   Pancreas                                           (53)         (51)         (53)         (53)         (53)         (65)         
      Edema                                                                      1 [2.0]                   4 [1.8]     19 [1.8]     
      Hemorrhage                                                                                                        2 [2.5]     
      Inflammation, Chronic Active                     1 [1.0]      5 [1.8]      4 [1.5]      3 [1.3]      2 [1.5]      6 [1.8]     
      Lipomatosis                                                   1 [2.0]      1 [2.0]                                            
      Acinus, Atrophy                                  1 [1.0]      5 [1.8]      3 [1.3]      5 [1.8]      9 [1.2]      8 [1.8]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Hyperplasia                              2 [1.5]                                                                      
      Acinus, Hyperplasia, Focal                       1 [2.0]                                                                      
      Acinus, Vacuolization Cytoplasmic                             1 [1.0]      8 [1.0]     39 [1.6]     49 [1.9]     43 [1.6]     
      Artery, Inflammation, Chronic Active                          2 [3.0]      2 [2.0]     21 [2.3]     14 [2.6]      4 [2.3]     
      Duct, Dilatation                                                                        1 [2.0]      3 [3.0]                  
   Salivary Glands                                    (53)         (51)         (53)         (52)         (52)         (66)         
      Atrophy                                          1 [2.0]                                                                      
   Stomach, Forestomach                               (53)         (51)         (53)         (53)         (53)         (65)         
      Edema                                                                                   2 [2.5]      1 [2.0]                  
      Erosion                                                       1 [2.0]                   1 [2.0]                               
      Hemorrhage                                                                                                        1 [2.0]     
      Hyperplasia, Squamous                            4 [1.5]      1 [2.0]      3 [2.3]     11 [2.0]      4 [1.8]      9 [1.9]     
      Inflammation                                     2 [3.0]                   2 [2.5]      4 [1.8]                   1 [1.0]     
      Mineralization                                                                          1 [1.0]                   2 [1.0]     
      Ulcer                                            2 [2.0]                   1 [3.0]      1 [2.0]                   1 [1.0]     
      Artery, Inflammation, Chronic Active                                                    2 [2.5]                               
   Stomach, Glandular                                 (53)         (51)         (53)         (53)         (53)         (65)         
      Cyst                                                                                                 1 [2.0]                  
      Erosion                                                       1 [2.0]                                1 [2.0]      2 [2.0]     
      Hemorrhage                                                                                           1 [2.0]      3 [1.7]     
      Inflammation                                                                                                      1 [1.0]     
      Mineralization                                  12 [1.3]      6 [1.3]      6 [1.5]      1 [2.0]      6 [1.2]      5 [1.6]     
      Glands, Cyst                                                                                                      1 [3.0]     
   Tongue                                                                       (1)                                                 
      Cyst                                                                       1 [2.0]                                            
   Tooth                                              (29)         (26)         (33)         (34)         (29)         (25)         
      Peridontal Tissue, Inflammation                 29 [1.6]     26 [1.2]     33 [1.2]     34 [1.8]     29 [1.3]     25 [1.4]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (51)         (52)         (53)         (53)         (66)         
      Mineralization                                   1 [1.0]                                                                      
      Aorta, Adventitia, Hemorrhage                                                                        1 [2.0]      1 [2.0]     
      Aorta, Adventitia, Inflammation                                                                      1 [3.0]      2 [2.0]     
   Heart                                              (53)         (51)         (53)         (53)         (53)         (65)         
      Cardiomyopathy                                  20 [1.2]     13 [1.1]     17 [1.0]     34 [1.1]     14 [1.0]     19 [1.3]     
      Atrium, Thrombosis                                                                                                1 [3.0]     
      Coronary Artery, Inflammation, Chronic Active    1 [1.0]      1 [2.0]                   7 [2.0]     10 [2.7]      9 [2.4]     
      Coronary Artery, Thrombosis                                                                          1 [2.0]                  
      Endocardium, Hyperplasia                                                                1 [3.0]                               
      Epicardium, Hemorrhage                                                                                            1 [2.0]     
      Epicardium, Inflammation                         1 [1.0]      1 [2.0]                   6 [1.2]     13 [1.5]      6 [1.5]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Myocardium, Hemorrhage                                                                                            3 [2.0]     
      Myocardium, Inflammation                                                                                          1 [2.0]     
      Myocardium, Necrosis                                                                                              2 [2.5]     
      Pericardium, Inflammation, Chronic Active                     1 [4.0]                                                         
      Valve, Fibrosis                                                                                      1 [2.0]                  
      Valve, Hyperplasia                                                         1 [4.0]                                            
      Ventricle, Thrombosis                                                                                             1 [3.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (51)         (53)         (53)         (53)         (65)         
      Angiectasis                                     42 [1.6]     35 [1.4]     39 [1.6]     25 [1.3]      4 [1.0]      6 [1.0]     
      Atrophy                                          2 [3.0]      1 [4.0]                  15 [2.4]     44 [2.4]     40 [2.4]     
      Degeneration, Cystic                            12 [2.2]     12 [2.3]     13 [1.8]     11 [2.1]      6 [2.2]      2 [1.5]     
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Hyperplasia                                     13 [2.0]      7 [2.1]     13 [2.1]     12 [2.1]     10 [2.2]      5 [2.0]     
      Hypertrophy                                     45 [2.0]     40 [2.1]     47 [2.1]     44 [2.3]     45 [2.0]     27 [1.6]     
      Inflammation                                                                            1 [3.0]                               
      Necrosis                                         1 [4.0]                   2 [2.0]      4 [2.3]      1 [2.0]      4 [2.0]     
      Vacuolization Cytoplasmic                       14 [1.6]     16 [1.6]     13 [1.5]     24 [1.7]     27 [1.7]     12 [1.5]     
   Adrenal Medulla                                    (53)         (51)         (53)         (53)         (53)         (64)         
      Hyperplasia                                     13 [1.8]      4 [2.5]      9 [2.3]     12 [2.1]      2 [2.0]                  
   Islets, Pancreatic                                 (53)         (51)         (53)         (53)         (53)         (65)         
      Hyperplasia                                                                1 [2.0]                                            
   Pituitary Gland                                    (53)         (51)         (52)         (53)         (53)         (65)         
      Angiectasis                                     23 [2.2]     13 [2.2]     19 [2.3]      7 [2.4]                               
      Cyst                                             1 [2.0]                                                                      
      Cytoplasmic Alteration                                        1 [1.0]      1 [1.0]                                            
      Necrosis                                                                                                          1 [2.0]     
      Vacuolization Cytoplasmic                        2 [2.0]      1 [1.0]                   5 [1.0]                               
      Pars Distalis, Hyperplasia                      11 [2.4]     14 [2.6]     19 [2.1]     18 [2.3]      4 [2.3]      1 [2.0]     
   Thyroid Gland                                      (53)         (51)         (53)         (52)         (52)         (66)         
      Hemorrhage                                                                                                        1 [3.0]     
      Inflammation                                                                                         1 [3.0]                  
      Artery, Inflammation, Chronic Active                                                                 1 [3.0]                  
      C-Cell, Hyperplasia                              7 [1.4]     11 [2.3]     13 [1.8]     10 [2.0]     15 [1.8]      3 [2.0]     
      Follicle, Cyst                                   1 [3.0]                                                                      
      Follicular Cell, Hyperplasia                                                                         2 [2.5]      1 [2.0]     
      Follicular Cell, Hypertrophy                    22 [1.2]     35 [1.4]     34 [1.8]     38 [1.8]     44 [1.9]     37 [1.7]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (51)         (51)         (52)         (52)         (66)         
      Inflammation                                    49 [1.9]     44 [1.6]     46 [1.4]     34 [1.2]     21 [1.1]     31 [1.1]     
      Artery, Inflammation, Chronic Active                                                    1 [3.0]                               
      Duct, Cyst                                      40 [2.2]     41 [2.2]     43 [2.1]     45 [2.3]     48 [2.4]     61 [2.4]     
   Ovary                                              (53)         (51)         (53)         (53)         (53)         (65)         
      Atrophy                                         46 [3.0]     34 [3.1]     43 [3.0]     42 [3.0]      7 [3.0]      9 [3.0]     
      Cyst                                            19 [2.2]     12 [2.3]     15 [2.3]     19 [2.3]      8 [1.9]     13 [2.1]     
      Inflammation                                                               3 [3.3]      3 [3.3]                               
      Inflammation, Chronic Active                                  1 [3.0]      3 [4.0]      3 [4.0]                               
      Artery, Inflammation                                                                    1 [4.0]                               
      Periovarian Tissue, Inflammation, Chronic                                                                                     
        Active                                                      1 [3.0]                                                         
   Oviduct                                                                                                (1)                       
      Cyst                                                                                                 1 [3.0]                  
      Inflammation                                                                                         1 [3.0]                  
   Uterus                                             (53)         (51)         (53)         (53)         (53)         (66)         
      Adenomyosis                                                   1 [3.0]                   3 [2.7]                   1 [2.0]     
      Congestion                                       1 [1.0]                                                                      
      Hemorrhage                                                                              2 [3.5]                   1 [3.0]     
      Hyperplasia, Cystic                              1 [1.0]                                                                      
      Inflammation, Chronic Active                     2 [1.0]      5 [1.8]      2 [3.0]      5 [3.2]                               
      Inflammation, Suppurative                        4 [1.5]      3 [2.3]      5 [1.4]      7 [3.0]                   2 [2.5]     
      Metaplasia, Squamous                            23 [1.7]     24 [2.4]     28 [2.4]     24 [2.5]                               
      Thrombosis                                                                                                        1 [2.0]     
      Endometrium, Hyperplasia, Cystic                32 [2.1]     23 [2.0]     25 [2.2]     30 [2.2]      7 [2.4]      8 [2.0]     
      Serosa, Inflammation, Chronic Active                          1 [4.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (51)         (53)         (53)         (53)         (66)         
      Atrophy                                                                                              2 [2.5]     12 [2.3]     
      Hyperplasia                                     37 [2.8]     41 [2.8]     36 [2.8]     48 [2.9]     47 [2.9]     49 [2.6]     
   Lymph Node                                         (28)         (16)         (16)         (25)         (20)         (45)         
      Hemorrhage                                                                              1 [2.0]                               
      Deep Cervical, Congestion                                                               1 [2.0]                               
      Deep Cervical, Ectasia                                                                  1 [1.0]                               
      Deep Cervical, Hemorrhage                                                               1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Deep Cervical, Hyperplasia, Histiocytic                                                 1 [2.0]                               
      Deep Cervical, Hyperplasia, Plasma Cell          1 [3.0]                                                                      
      Lumbar, Ectasia                                               1 [3.0]                   1 [3.0]                               
      Lumbar, Hemorrhage                               1 [2.0]                                                                      
      Lumbar, Hyperplasia, Plasma Cell                              1 [3.0]                                                         
      Mediastinal, Congestion                                                                 1 [2.0]                               
      Mediastinal, Ectasia                             7 [1.3]      7 [1.4]      7 [1.3]      7 [1.4]      7 [1.7]     27 [1.6]     
      Mediastinal, Hemorrhage                          2 [1.5]      2 [2.0]      4 [1.5]     15 [1.9]      7 [1.9]     25 [1.8]     
      Mediastinal, Hyperplasia, Histiocytic                                                   2 [2.0]      2 [2.0]      2 [2.5]     
      Mediastinal, Hyperplasia, Lymphoid                                         2 [4.0]                                            
      Mediastinal, Hyperplasia, Plasma Cell                         3 [2.0]                   1 [3.0]                               
      Mediastinal, Pigmentation                                                                                         2 [2.0]     
      Pancreatic, Ectasia                                                                                  1 [2.0]      1 [2.0]     
      Pancreatic, Hemorrhage                                                                               1 [2.0]      4 [1.8]     
      Pancreatic, Hyperplasia, Histiocytic                                                    1 [2.0]      4 [2.5]      3 [2.3]     
      Pancreatic, Hyperplasia, Lymphoid                                                       2 [3.0]                   1 [2.0]     
      Renal, Ectasia                                                1 [3.0]                   1 [3.0]      1 [2.0]                  
      Renal, Hemorrhage                                                                                    1 [2.0]                  
      Renal, Hyperplasia                                                                                   1 [2.0]                  
      Renal, Hyperplasia, Histiocytic                                                                      1 [3.0]      2 [3.0]     
   Lymph Node, Mandibular                             (53)         (51)         (53)         (52)         (52)         (66)         
      Atrophy                                                                                              1 [4.0]                  
      Ectasia                                          3 [2.7]      2 [2.0]      3 [2.0]      4 [2.3]      4 [2.0]      1 [2.0]     
      Hemorrhage                                                                 1 [2.0]                   2 [1.5]      7 [2.0]     
      Hyperplasia, Histiocytic                                                                1 [2.0]                               
      Hyperplasia, Lymphoid                                         1 [3.0]      3 [2.7]                   2 [3.5]      1 [2.0]     
      Hyperplasia, Plasma Cell                        45 [2.2]     35 [2.1]     34 [2.1]     27 [2.2]     22 [2.2]     20 [2.1]     
      Necrosis                                                                                                          1 [1.0]     
      Necrosis, Lymphoid                                                                                                1 [1.0]     
      Pigmentation                                                                                                      1 [2.0]     
   Lymph Node, Mesenteric                             (53)         (51)         (53)         (53)         (52)         (65)         
      Ectasia                                          1 [2.0]      1 [3.0]                   2 [2.0]      1 [2.0]      2 [2.0]     
      Hemorrhage                                                    2 [1.5]      2 [2.0]      2 [2.0]      4 [1.5]     14 [2.1]     
      Hyperplasia, Histiocytic                         2 [2.0]                   1 [2.0]      6 [1.8]      5 [2.2]                  
      Hyperplasia, Lymphoid                                                                                1 [4.0]      1 [3.0]     
      Hyperplasia, Plasma Cell                         1 [2.0]                                                                      
   Spleen                                             (53)         (51)         (53)         (53)         (53)         (65)         
      Hematopoietic Cell Proliferation                49 [2.2]     44 [2.3]     49 [2.0]     52 [2.0]     50 [1.9]     43 [1.5]     
      Pigmentation                                    52 [1.6]     50 [1.3]     52 [1.4]     50 [1.4]     50 [1.3]     59 [1.1]     
      Artery, Inflammation, Chronic Active                                                                              1 [3.0]     
      Capsule, Fibrosis                                1 [3.0]                                                                      
      Lymphoid Follicle, Atrophy                       4 [2.5]      5 [2.0]      2 [2.5]      5 [2.2]      3 [2.3]      9 [2.6]     
      Red Pulp, Atrophy                                                                                    1 [2.0]      2 [2.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (53)         (51)         (51)         (51)         (51)         (59)         
      Atrophy                                         40 [2.7]     44 [2.5]     44 [3.0]     49 [3.9]     50 [3.8]     57 [3.8]     
      Hemorrhage                                                                 2 [3.0]                                            
      Necrosis                                                                                1 [3.0]                               
      Artery, Inflammation, Chronic Active                          1 [3.0]                                1 [3.0]      1 [2.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (51)         (53)         (53)         (53)         (66)         
      Cyst                                             1 [3.0]      2 [2.5]      2 [3.0]      2 [2.0]                               
      Hyperplasia                                     26 [1.5]     17 [1.5]     13 [1.4]      6 [1.8]      6 [1.2]                  
      Inflammation                                                  1 [3.0]                                                         
      Inflammation, Granulomatous                      3 [2.3]      2 [2.0]      1 [3.0]                                            
   Skin                                               (53)         (51)         (53)         (53)         (53)         (66)         
      Cyst Epithelial Inclusion                                     1                         2            1                        
      Hemorrhage                                                                                                        1 [2.0]     
      Inflammation                                                                                         1 [3.0]      1 [2.0]     
      Ulcer                                                                                                1 [3.0]                  
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
        Active                                                                                             1 [3.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (51)         (53)         (53)         (53)         (66)         
      Hemorrhage                                                    1 [1.0]      1 [1.0]      4 [1.3]      5 [2.0]     14 [2.2]     
      Hydrocephalus                                                              1 [2.0]                                            
      Inflammation                                                                            2 [2.0]      1 [3.0]                  
      Mineralization                                                                                                    1 [1.0]     
      Necrosis                                                                                2 [3.0]      1 [3.0]                  
      Artery, Inflammation, Chronic Active                                                                 1 [2.0]                  
      Cerebrum, Degeneration                                                                  1 [2.0]                               
      Meninges, Inflammation                                                                               1 [3.0]                  
      Meninges, Vein, Thrombosis                                                                           1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (51)         (53)         (53)         (53)         (66)         
      Congestion                                                                              2 [2.5]                               
      Hemorrhage                                                                              1 [3.0]      2 [1.0]      4 [1.3]     
      Infiltration Cellular, Histiocyte               40 [1.7]     33 [1.6]     46 [1.7]     48 [1.5]     46 [1.1]     33 [1.0]     
      Inflammation                                     5 [1.6]      9 [1.4]      7 [1.1]      3 [3.3]      2 [3.0]      2 [1.5]     
      Metaplasia, Squamous                                          1 [1.0]      2 [1.5]     14 [2.1]     16 [2.3]      7 [2.6]     
      Necrosis                                                                   1 [3.0]                                            
      Alveolar Epithelium, Hyperplasia                18 [1.2]     10 [1.2]      2 [1.0]      1 [1.0]      1 [1.0]      4 [1.3]     
      Alveolar Epithelium, Metaplasia, Bronchiolar     1 [1.0]     14 [1.3]     39 [1.4]     46 [1.6]     35 [1.1]      8 [1.0]     
      Artery, Thrombosis                                                                                                1 [2.0]     
      Artery, Mediastinum, Inflammation, Chronic                                                                                    
        Active                                                                                                          1 [3.0]     
      Mediastinum, Inflammation                                                                            1 [3.0]                  
      Serosa, Fibrosis                                 3 [1.3]                                1 [3.0]     16 [1.6]      8 [1.8]     
   Nose                                               (53)         (51)         (53)         (53)         (53)         (66)         
      Inflammation                                    17 [1.2]     15 [1.4]     16 [1.3]     10 [1.7]     22 [1.7]     11 [1.4]     
      Necrosis                                                                                             1 [4.0]                  
      Ulcer                                                                                                1 [2.0]                  
      Glands, Hyperplasia                                                                                  2 [3.0]                  
      Olfactory Epithelium, Degeneration                                                      1 [2.0]                               
      Olfactory Epithelium, Metaplasia                              2 [2.0]      1 [2.0]      3 [2.3]      8 [2.3]      1 [2.0]     
      Respiratory Epithelium, Hyperplasia              8 [1.6]     11 [1.8]      5 [1.4]      8 [2.0]     16 [2.4]      9 [1.9]     
      Squamous Epithelium, Hyperplasia                                           1 [1.0]                   2 [2.0]      1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (53)         (51)         (53)         (53)         (53)         (66)         
      Cataract                                         1 [3.0]      3 [3.0]                                                         
      Cornea, Inflammation                                          1 [2.0]                   1 [3.0]      1 [3.0]                  
      Iris, Inflammation                               1 [2.0]                                                                      
      Retina, Atrophy                                  1 [3.0]      3 [2.7]                   1 [2.0]                   1 [2.0]     
      Retina, Degeneration                                                                                              1 [2.0]     
   Harderian Gland                                    (53)         (51)         (53)         (53)         (53)         (66)         
      Inflammation                                    24 [1.1]      7 [1.4]     20 [1.0]     13 [1.2]      7 [1.0]      9 [1.1]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (51)         (53)         (53)         (53)         (65)         
      Calculus Micro Observation Only                  6            6            6                                                  
      Cyst                                                          2 [2.5]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Infarct                                          2 [3.5]                                                          1 [3.0]     
      Inflammation, Chronic Active                     1 [3.0]                                                                      
      Inflammation, Suppurative                                     1 [1.0]      4 [1.8]      3 [2.3]                   1 [1.0]     
      Mineralization                                  46 [1.0]     34 [1.1]     38 [1.1]     44 [1.0]     34 [1.1]     37 [1.1]     
      Necrosis                                                                                                          1 [3.0]     
      Nephropathy                                     41 [1.1]     37 [1.2]     37 [1.2]     48 [2.0]     50 [2.0]     43 [1.4]     
      Pigmentation                                                                                         1 [2.0]                  
      Artery, Inflammation, Chronic Active                                                    1 [3.0]                               
      Pelvis, Dilatation                                                         1 [2.0]                                            
      Pelvis, Inflammation                             4 [2.8]      6 [1.7]      1 [2.0]      6 [2.5]                               
      Renal Tubule, Hyperplasia                        2 [1.5]                                                                      
      Transitional Epithelium, Hyperplasia             4 [2.3]      6 [1.8]      6 [1.5]     16 [2.3]      1 [3.0]                  
      Transitional Epithelium, Metaplasia, Squamous                                           1 [3.0]                               
   Ureter                                             (1)                                                                           
      Transitional Epithelium, Hyperplasia             1 [2.0]                                                                      
   Urinary Bladder                                    (53)         (51)         (53)         (53)         (52)         (66)         
      Calculus Gross Observation                       1                                                                            
      Edema                                            1 [3.0]                                                                      
      Inflammation                                     8 [1.9]      3 [1.3]      2 [1.5]      4 [2.3]      1 [2.0]                  
      Metaplasia, Squamous                                                                    1 [3.0]                               
      Artery, Inflammation, Chronic Active                                                    1 [3.0]                               
      Transitional Epithelium, Hyperplasia             4 [2.3]      2 [1.5]                   4 [2.3]      1 [3.0]                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   4000 NG/                                                                      
                                                      500UG ST                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50                                                                            
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28                                                                            
    Natural Death                                     12                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)                                                                          
      Parasite Metazoan                                1                                                                            
   Intestine Large, Rectum                            (50)                                                                          
      Parasite Metazoan                                1                                                                            
      Artery, Inflammation, Chronic Active             4 [2.3]                                                                      
   Intestine Large, Cecum                             (50)                                                                          
      Edema                                            1 [2.0]                                                                      
      Inflammation                                     1 [2.0]                                                                      
      Artery, Inflammation, Chronic Active             1 [2.0]                                                                      
   Intestine Small, Ileum                             (50)                                                                          
      Parasite Metazoan                                1                                                                            
   Liver                                              (50)                                                                          
      Angiectasis                                      4 [2.3]                                                                      
      Basophilic Focus                                 2                                                                            
      Basophilic Focus, Multiple                       3                                                                            
      Cholangiofibrosis                               27 [2.0]                                                                      
      Clear Cell Focus                                 1                                                                            
      Degeneration, Cystic                             1 [2.0]                                                                      
      Eosinophilic Focus                               1                                                                            
      Eosinophilic Focus, Multiple                    14                                                                            
      Fatty Change, Diffuse                           35 [1.4]                                                                      
      Fatty Change, Focal                             14 [2.1]                                                                      
      Hematopoietic Cell Proliferation                22 [1.1]                                                                      
      Hemorrhage                                       1 [2.0]                                                                      
      Hepatodiaphragmatic Nodule                       1                                                                            
      Hyperplasia, Nodular                            34                                                                            
      Inflammation                                    48 [1.0]                                                                      
      Metaplasia                                       2 [1.5]                                                                      
      Mixed Cell Focus                                 1                                                                            
      Mixed Cell Focus, Multiple                      19                                                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   4000 NG/                                                                      
                                                      500UG ST                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis                                         6 [2.0]                                                                      
      Pigmentation                                    50 [1.9]                                                                      
      Toxic Hepatopathy                               50 [2.6]                                                                      
      Bile Duct, Cyst                                 21 [2.7]                                                                      
      Bile Duct, Fibrosis                             12 [1.9]                                                                      
      Bile Duct, Hyperplasia                          37 [1.8]                                                                      
      Centrilobular, Degeneration                      6 [2.0]                                                                      
      Centrilobular, Fibrosis                         43 [1.9]                                                                      
      Hepatocyte, Glandular Structures                 9 [2.3]                                                                      
      Hepatocyte, Hypertrophy                         36 [2.7]                                                                      
      Hepatocyte, Multinucleated                      38 [1.6]                                                                      
      Oval Cell, Hyperplasia                          43 [2.3]                                                                      
      Portal, Fibrosis                                42 [2.3]                                                                      
      Serosa, Fibrosis                                 1 [1.0]                                                                      
   Mesentery                                          (43)                                                                          
      Necrosis                                         1 [3.0]                                                                      
      Artery, Inflammation, Chronic Active             7 [2.0]                                                                      
   Oral Mucosa                                        (50)                                                                          
      Gingival, Hyperplasia, Squamous                 18 [1.4]                                                                      
   Pancreas                                           (50)                                                                          
      Edema                                           12 [1.7]                                                                      
      Hemorrhage                                       1 [2.0]                                                                      
      Inflammation, Chronic Active                     5 [1.6]                                                                      
      Acinus, Atrophy                                  8 [2.4]                                                                      
      Acinus, Vacuolization Cytoplasmic               41 [1.6]                                                                      
      Artery, Inflammation, Chronic Active            10 [1.8]                                                                      
   Stomach, Forestomach                               (50)                                                                          
      Edema                                            1 [2.0]                                                                      
      Hyperplasia, Squamous                            2 [1.5]                                                                      
      Inflammation                                     2 [2.0]                                                                      
      Mineralization                                   1 [2.0]                                                                      
      Ulcer                                            2 [2.0]                                                                      
   Stomach, Glandular                                 (50)                                                                          
      Mineralization                                   1 [1.0]                                                                      
      Artery, Inflammation, Chronic Active             1 [3.0]                                                                      
   Tooth                                              (23)                                                                          
      Peridontal Tissue, Inflammation                 23 [1.6]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)                                                                          
      Aorta, Adventitia, Hemorrhage                    2 [2.5]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   4000 NG/                                                                      
                                                      500UG ST                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Aorta, Adventitia, Inflammation                  2 [1.5]                                                                      
   Heart                                              (50)                                                                          
      Cardiomyopathy                                  15 [1.1]                                                                      
      Atrium, Thrombosis                               1 [1.0]                                                                      
      Coronary Artery, Inflammation, Chronic Active    6 [2.0]                                                                      
      Epicardium, Inflammation                         1 [1.0]                                                                      
      Myocardium, Hemorrhage                           1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)                                                                          
      Angiectasis                                     21 [1.2]                                                                      
      Atrophy                                         12 [2.3]                                                                      
      Degeneration, Cystic                             9 [2.4]                                                                      
      Hyperplasia                                     10 [2.2]                                                                      
      Hypertrophy                                     29 [2.2]                                                                      
      Inflammation                                     2 [2.0]                                                                      
      Necrosis                                         2 [2.0]                                                                      
      Vacuolization Cytoplasmic                       16 [1.6]                                                                      
   Adrenal Medulla                                    (49)                                                                          
      Hyperplasia                                      8 [2.0]                                                                      
   Pituitary Gland                                    (50)                                                                          
      Angiectasis                                      3 [1.3]                                                                      
      Cyst                                             3 [2.3]                                                                      
      Cytoplasmic Alteration                           2 [2.5]                                                                      
      Pars Distalis, Hyperplasia                       8 [2.0]                                                                      
      Pars Intermedia, Hyperplasia                     1 [3.0]                                                                      
   Thyroid Gland                                      (49)                                                                          
      Infiltration Cellular, Lymphoid                  2 [3.0]                                                                      
      C-Cell, Hyperplasia                              6 [2.2]                                                                      
      Follicular Cell, Hypertrophy                    29 [1.7]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)                                                                          
      Inflammation                                    30 [1.2]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   4000 NG/                                                                      
                                                      500UG ST                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Duct, Cyst                                      40 [2.1]                                                                      
   Ovary                                              (50)                                                                          
      Atrophy                                         15 [2.7]                                                                      
      Cyst                                             7 [2.3]                                                                      
   Uterus                                             (50)                                                                          
      Congestion                                       1 [2.0]                                                                      
      Hemorrhage                                       1 [2.0]                                                                      
      Inflammation, Chronic Active                     1 [2.0]                                                                      
      Inflammation, Suppurative                        4 [2.3]                                                                      
      Metaplasia, Squamous                             8 [1.6]                                                                      
      Cervix, Stromal Hyperplasia                      1 [3.0]                                                                      
      Endometrium, Hyperplasia, Cystic                17 [2.4]                                                                      
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                                                                          
      Atrophy                                          4 [2.0]                                                                      
      Hyperplasia                                     40 [2.6]                                                                      
   Lymph Node                                         (22)                                                                          
      Lumbar, Hemorrhage                               1 [1.0]                                                                      
      Lumbar, Hyperplasia, Histiocytic                 1 [2.0]                                                                      
      Mediastinal, Ectasia                             3 [2.0]                                                                      
      Mediastinal, Hemorrhage                         11 [2.0]                                                                      
      Mediastinal, Hyperplasia, Histiocytic            4 [2.3]                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 [4.0]                                                                      
      Mediastinal, Hyperplasia, Plasma Cell            1 [2.0]                                                                      
      Pancreatic, Hemorrhage                           3 [2.0]                                                                      
      Pancreatic, Hyperplasia, Histiocytic             3 [2.3]                                                                      
      Pancreatic, Hyperplasia, Lymphoid                1 [3.0]                                                                      
      Renal, Ectasia                                   1 [3.0]                                                                      
      Renal, Hemorrhage                                2 [2.0]                                                                      
      Renal, Hyperplasia, Histiocytic                  3 [2.0]                                                                      
   Lymph Node, Mandibular                             (49)                                                                          
      Ectasia                                         11 [2.3]                                                                      
      Hemorrhage                                       4 [1.8]                                                                      
      Hyperplasia, Plasma Cell                        28 [2.3]                                                                      
      Inflammation                                     1 [2.0]                                                                      
   Lymph Node, Mesenteric                             (50)                                                                          
      Ectasia                                          1 [2.0]                                                                      
      Hemorrhage                                      10 [1.9]                                                                      
      Hyperplasia, Histiocytic                         1 [3.0]                                                                      
      Hyperplasia, Plasma Cell                         1 [2.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   4000 NG/                                                                      
                                                      500UG ST                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)                                                                          
      Hematopoietic Cell Proliferation                45 [1.9]                                                                      
      Pigmentation                                    41 [1.4]                                                                      
      Lymphoid Follicle, Atrophy                       4 [2.5]                                                                      
   Thymus                                             (46)                                                                          
      Atrophy                                         45 [3.4]                                                                      
      Hemorrhage                                       1 [3.0]                                                                      
      Artery, Inflammation, Chronic Active             1 [4.0]                                                                      
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                                                          
      Cyst                                             1 [3.0]                                                                      
      Hyperplasia                                     11 [1.6]                                                                      
      Inflammation, Granulomatous                      1 [2.0]                                                                      
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                                                                          
      Tarsal, Inflammation                             1 [3.0]                                                                      
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                                                                          
      Hemorrhage                                       8 [1.8]                                                                      
      Mineralization                                   1 [1.0]                                                                      
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                                                          
      Hemorrhage                                       3 [1.3]                                                                      
      Infiltration Cellular, Histiocyte               24 [1.2]                                                                      
      Inflammation                                     6 [2.2]                                                                      
      Inflammation, Granulomatous                      4 [3.0]                                                                      
      Keratin Cyst                                     9 [3.3]                                                                      
      Metaplasia, Squamous                             8 [1.9]                                                                      
      Alveolar Epithelium, Hyperplasia                 5 [1.0]                                                                      
      Alveolar Epithelium, Metaplasia, Bronchiolar    15 [1.2]                                                                      
      Serosa, Fibrosis                                 1 [1.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   15                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/29/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 17:03:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   4000 NG/                                                                      
                                                      500UG ST                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (50)                                                                          
      Inflammation                                    11 [1.7]                                                                      
      Olfactory Epithelium, Metaplasia                 5 [2.4]                                                                      
      Respiratory Epithelium, Hyperplasia             10 [2.5]                                                                      
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)                                                                          
      Retina, Atrophy                                  1 [2.0]                                                                      
   Harderian Gland                                    (50)                                                                          
      Inflammation                                    12 [1.0]                                                                      
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)                                                                          
      Accumulation, Hyaline Droplet                    1 [1.0]                                                                      
      Cyst                                             1 [2.0]                                                                      
      Mineralization                                  32 [1.0]                                                                      
      Nephropathy                                     34 [2.0]                                                                      
   Urinary Bladder                                    (50)                                                                          
      Inflammation                                     1 [1.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   16                                                              
                                                                                                                                   
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