National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19861

TDMS Study 88138-03 Pathology Tables

NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01

                                                         FINAL #1 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  04/26/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           10            9           13                                     
    Natural Death                                      2            2            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           38           37           34                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 [2.0]                                                         
      Periesophageal Tissue, Necrosis, Fatty                        1 [2.0]                                                         
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 [2.0]                                                                      
      Metaplasia, Mucous                               1 [3.0]                                                                      
      Parasite Metazoan                                1 [1.0]      3 [1.0]      2 [1.0]      3 [1.0]                               
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                8 [1.1]      8 [1.1]     14 [1.2]      6 [1.0]                               
      Ulcer                                                         1 [3.0]                                                         
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 [3.0]                                                         
      Mineralization                                                             1 [1.0]                                            
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                             1 [3.0]                               
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 [2.0]      2 [1.0]                                            
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 [1.0]      2 [1.0]      5 [1.4]      1 [1.0]                               
      Basophilic Focus                                48           48           41           43                                     
      Clear Cell Focus                                15           13           10           10                                     
      Degeneration, Cystic                             1 [1.0]                   3 [1.7]      4 [1.3]                               
      Eosinophilic Focus                                            6            6            9                                     
      Fatty Change, Diffuse                           11 [1.5]      8 [2.1]      9 [2.1]     20 [1.5]                               
      Fibrosis                                                                                1 [3.0]                               
      Hematopoietic Cell Proliferation                 1 [1.0]      6 [1.2]      4 [1.0]      2 [1.5]                               
      Hepatodiaphragmatic Nodule                       5            6            6            6                                     
      Inflammation, Chronic Active                    46 [1.5]     38 [1.5]     29 [1.3]     30 [1.4]                               
      Mixed Cell Focus                                10           11            5            5                                     
      Necrosis                                        12 [1.1]      6 [1.3]     11 [1.7]     12 [1.3]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Cyst                                                                         1                                     
      Bile Duct, Hyperplasia                          10 [1.3]     35 [1.2]     39 [1.4]     40 [1.6]                               
      Hepatocyte, Centrilobular, Hypertrophy                       27 [1.0]     30 [1.3]     33 [2.0]                               
      Oval Cell, Hyperplasia                                                                  3 [2.0]                               
   Mesentery                                          (12)         (18)         (10)         (6)                                    
      Fat, Necrosis                                   11 [1.4]     18 [2.0]     10 [1.8]      4 [2.0]                               
   Oral Mucosa                                        (4)          (8)          (4)          (4)                                    
      Hyperplasia, Squamous                                                                   1 [2.0]                               
      Gingival, Inflammation                           4 [1.5]      7 [1.1]      4 [1.0]      4 [1.3]                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                                           1 [1.0]      1 [1.0]                               
      Inflammation                                    12 [1.2]      3 [1.0]      2 [1.0]      6 [1.0]                               
      Acinus, Atrophy                                 17 [1.2]     10 [1.0]     11 [1.5]     12 [1.5]                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 [1.0]                   1 [1.0]      1 [2.0]                               
      Basophilic Focus                                 1 [1.0]                   1 [1.0]                                            
      Inflammation                                                               1 [2.0]                                            
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            2 [2.0]      2 [2.5]      2 [2.0]      4 [2.3]                               
      Inflammation                                     4 [1.3]      2 [1.5]      2 [1.5]      3 [2.3]                               
      Ulcer                                                         1 [3.0]      1 [2.0]      2 [3.5]                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                                       1 [2.0]      1 [2.0]      1 [2.0]                               
      Inflammation                                                               2 [1.5]      3 [1.7]                               
      Mineralization                                                2 [1.0]      2 [1.0]                                            
      Ulcer                                            1 [1.0]                                1 [3.0]                               
      Epithelium, Atrophy                                                        1 [2.0]                                            
   Tooth                                                                        (3)          (3)                                    
      Inflammation                                                               3 [2.0]      2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Mineralization                                                                          1 [1.0]                               
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  46 [1.3]     46 [1.4]     48 [1.3]     46 [1.4]                               
      Atrium, Thrombosis                                            1 [1.0]                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Angiectasis                                     42 [1.4]     36 [1.1]     18 [1.0]     24 [1.0]                               
      Atrophy                                          1 [1.0]                                1 [2.0]                               
      Degeneration, Cystic                             3 [1.0]      2 [1.0]      2 [1.0]                                            
      Hematopoietic Cell Proliferation                 3 [1.0]      1 [1.0]      2 [1.0]      2 [1.0]                               
      Hyperplasia                                      6 [1.2]     10 [1.1]      6 [2.0]      6 [1.2]                               
      Hypertrophy                                      7 [1.0]      5 [1.4]      5 [1.0]      8 [1.0]                               
      Karyomegaly                                      1 [1.0]                                                                      
      Necrosis                                         5 [1.4]      7 [1.4]      5 [1.4]      2 [2.5]                               
      Vacuolization Cytoplasmic                       14 [1.3]     16 [1.4]     15 [1.7]     20 [1.3]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 [1.0]      2 [2.5]                                            
      Necrosis                                         2 [2.0]                                                                      
      Vacuolization Cytoplasmic                        1 [1.0]                                                                      
   Parathyroid Gland                                  (47)         (48)         (44)         (48)                                   
      Hyperplasia                                                   1 [1.0]                   1 [2.0]                               
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                     30 [2.2]     30 [2.3]     23 [2.3]     23 [2.0]                               
      Cyst                                             2 [1.0]      1 [2.0]      1 [1.0]      2 [2.0]                               
      Hyperplasia                                     23 [2.2]     24 [2.5]     20 [2.8]     18 [1.9]                               
      Inflammation                                     1 [1.0]                                                                      
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             34 [1.8]     11 [1.8]     13 [1.7]      8 [1.9]                               
      Follicle, Cyst                                   1 [2.0]                   1 [1.0]      1 [2.0]                               
      Follicle, Hyperplasia                                         2 [1.0]                                                         
      Follicular Cell, Hyperplasia                                               1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 [4.0]                                            
      Cyst                                             3 [2.3]      2 [2.5]      1 [3.0]                                            
      Hyperplasia                                      6 [2.2]      1 [2.0]      2 [2.5]                                            
      Hyperplasia, Squamous                                                                   1 [2.0]                               
      Inflammation                                     2 [3.0]      2 [2.5]      2 [3.0]                                            
      Metaplasia, Squamous                             1 [2.0]                                                                      
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             6           13           10            9                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Interstitial Cell, Hyperplasia                                1 [2.0]                                                         
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                                      1 [2.0]                               
      Inflammation                                                                            1 [2.0]                               
      Cervix, Hypertrophy                                                                     1 [3.0]                               
      Endometrium, Hyperplasia, Cystic                12 [1.8]     20 [1.9]     20 [2.2]     20 [2.3]                               
      Endometrium, Hyperplasia, Adenomatous            1 [2.0]      1 [3.0]                   1 [3.0]                               
      Serosa, Inflammation, Granulomatous                           2 [1.0]                                                         
   Vagina                                                          (1)          (1)                                                 
      Inflammation                                                               1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                      1 [2.0]      1 [2.0]      1 [1.0]      1 [1.0]                               
      Myelofibrosis                                    2 [1.0]                   2 [1.5]      6 [1.5]                               
      Necrosis                                                                   1 [2.0]      1 [2.0]                               
      Erythroid Cell, Hyperplasia                      8 [1.1]      6 [1.0]      7 [1.9]      2 [1.5]                               
      Myeloid Cell, Hyperplasia                       11 [1.7]     13 [2.5]     20 [2.5]     13 [2.6]                               
   Lymph Node                                         (8)          (8)          (11)         (12)                                   
      Axillary, Right, Ectasia                                                   1 [3.0]                                            
      Axillary, Right, Infiltration Cellular,                                                                                       
        Plasma Cell                                                              1 [4.0]                                            
      Deep Cervical, Ectasia                           1 [1.0]                                                                      
      Deep Cervical, Hemorrhage                        1 [2.0]                                                                      
      Deep Cervical, Infiltration Cellular, Plasma                                                                                  
        Cell                                           3 [1.7]                                2 [1.5]                               
      Deep Cervical, Infiltration Cellular,                                                                                         
        Histiocyte                                     3 [1.7]                                                                      
      Mediastinal, Hemorrhage                                                                 2 [3.0]                               
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                           2 [1.5]      1 [2.0]      4 [2.3]      2 [2.0]                               
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                                               1 [1.0]      1 [1.0]                               
      Pancreatic, Hemorrhage                                        2 [2.0]                                                         
      Pancreatic, Infiltration Cellular, Histiocyte                 3 [2.3]                   1 [2.0]                               
      Pancreatic, Pigmentation, Hemosiderin                         2 [3.0]                                                         
      Renal, Infiltration Cellular, Histiocyte                      1 [3.0]                   1 [3.0]                               
      Renal, Pigmentation                                                                     1 [2.0]                               
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Plasma Cell                            1 [2.0]      1 [2.0]      2 [2.0]                               
      Infiltration Cellular, Histiocyte               50 [1.6]     49 [1.4]     48 [1.5]     49 [1.4]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Accessory Spleen                                                           1 [1.4]      1 [2.0]                               
      Autolysis                                                                  2                                                  
      Fibrosis                                         1 [3.0]                                1 [1.0]                               
      Hematopoietic Cell Proliferation                47 [1.1]     45 [1.0]     40 [1.2]     45 [1.1]                               
      Hyperplasia, Lymphoid                                         1 [2.0]      1 [3.0]      2 [2.5]                               
      Infarct                                          1 [4.0]                                                                      
      Inflammation, Granulomatous                      1 [2.0]      1 [4.0]                                                         
      Pigmentation, Hemosiderin                       48 [1.1]     50 [1.0]     49 [1.0]     49 [1.0]                               
      Lymphoid Follicle, Atrophy                                    5 [1.6]                                                         
      Red Pulp, Hyperplasia                                                                   1 [2.0]                               
   Thymus                                             (50)         (49)         (46)         (50)                                   
      Atrophy                                         49 [3.3]     48 [3.4]     44 [3.4]     49 [3.3]                               
      Cyst                                                                                    1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 [3.0]                               
      Galactocele                                      7            3            2            2                                     
      Hyperplasia                                      3 [1.0]      4 [2.0]      1 [3.0]      3 [2.0]                               
      Inflammation                                     1 [3.0]      1 [1.0]      1 [2.0]                                            
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                  1            1                                     
      Sebaceous Gland, Hyperplasia                                                            1 [3.0]                               
      Subcutaneous Tissue, Necrosis                                              1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                                                  2 [1.0]                               
   Skeletal Muscle                                    (1)          (1)          (3)          (1)                                    
      Inflammation                                     1 [3.0]      1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                                    1 [1.0]                                            
      Hemorrhage                                       2 [3.0]      1 [1.0]      2 [1.0]                                            
      Hydrocephalus                                    1 [3.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Inflammation                                     1 [1.0]      1 [1.0]      1 [1.0]                                            
      Mineralization                                   1 [2.0]                                                                      
      Necrosis                                                      1 [1.0]      1 [1.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                                           2 [1.0]      1 [2.0]                                            
      Inflammation, Granulomatous                     12 [1.1]      5 [1.0]      9 [1.4]      7 [1.4]                               
      Metaplasia, Squamous                                                       1 [1.0]                                            
      Alveolar Epithelium, Hyperplasia                18 [1.5]     18 [1.4]     13 [1.2]     15 [1.3]                               
      Alveolus, Infiltration Cellular, Histiocyte     50 [2.0]     50 [2.0]     50 [2.0]     50 [1.9]                               
      Interstitium, Fibrosis                                                     1 [3.0]                                            
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation                                     2 [2.5]      1 [1.0]      3 [1.3]      1 [1.0]                               
      Thrombosis                                                                 2 [2.0]                                            
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Inflammation                                                  4 [1.3]      2 [1.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 [1.0]      1 [3.0]      2 [2.0]      1 [1.0]                               
      Lens, Cataract                                   1 [3.0]      1 [2.0]      2 [1.5]      2 [3.5]                               
      Optic Nerve, Fibrosis                                                                   1 [2.0]                               
      Retina, Degeneration                             2 [2.5]      2 [2.5]      4 [3.0]      4 [3.0]                               
      Retina, Dysplasia                                             1 [2.0]                                                         
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 14 [1.0]     10 [1.0]      6 [1.0]      9 [1.1]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                              2 [2.5]      1 [4.0]                               
      Fibrosis                                         1 [4.0]                                                                      
      Infarct                                                       1            2            1                                     
      Inflammation, Chronic Active                     1 [2.0]                                                                      
      Nephropathy                                     47 [1.1]     49 [1.4]     48 [1.7]     49 [2.0]                               
      Cortex, Inflammation                                                                    1 [2.0]                               
      Cortex, Mineralization                           2 [1.0]      1 [1.0]      4 [1.0]      1 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Medulla, Fibrosis                                1 [2.0]                                                                      
      Medulla, Mineralization                         43 [1.0]     49 [1.1]     49 [1.1]     46 [1.1]                               
      Pelvis, Inflammation                             1 [3.0]                   4 [1.8]      2 [1.5]                               
      Pelvis, Transitional Epithelium, Hyperplasia     1 [1.0]      2 [1.5]      2 [2.0]      4 [1.0]                               
      Renal Tubule, Cyst                                                                      1                                     
      Renal Tubule, Hyperplasia                                     1 [4.0]      1 [3.0]      1 [4.0]                               
      Renal Tubule, Pigmentation                                                              1 [2.0]                               
      Renal Tubule, Vacuolization Cytoplasmic                       1 [2.0]                                                         
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 [3.0]      1 [3.0]                                            
      Inflammation                                     1 [1.0]      1 [1.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           12           16           44                                     
    Natural Death                                      3           11            3            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           27           31            2                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Erosion                                                                    1 [2.0]                                            
      Inflammation                                                               1 [2.0]                                            
      Parasite Metazoan                                1 [1.0]      1 [1.0]      1 [1.0]                                            
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                6 [1.0]      6 [1.2]      8 [1.0]      5 [1.0]                               
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Erosion                                          1 [2.0]                   1 [1.0]      1 [4.0]                               
      Inflammation                                                                            4 [3.0]                               
      Mineralization                                                                          2 [2.0]                               
      Ulcer                                                                                   1 [3.0]                               
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          1 [3.0]                                                         
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 [3.0]                                                         
      Basophilic Focus                                24           25           32           19                                     
      Clear Cell Focus                                19           19           18                                                  
      Congestion                                       1 [2.0]                                                                      
      Degeneration, Cystic                             8 [1.3]     11 [1.0]     20 [1.3]     15 [1.2]                               
      Eosinophilic Focus                               5           14           10            9                                     
      Fatty Change, Diffuse                           22 [2.3]     20 [1.7]     22 [1.5]     15 [1.7]                               
      Hematopoietic Cell Proliferation                 4 [1.3]      1 [2.0]      2 [1.0]      4 [1.0]                               
      Hepatodiaphragmatic Nodule                       2            6            1            1                                     
      Infarct                                                                                 1                                     
      Inflammation, Chronic Active                    22 [1.9]     21 [1.6]     35 [1.9]     33 [1.8]                               
      Inflammation, Granulomatous                      1 [4.0]                                2 [2.5]                               
      Mineralization                                                                          1 [1.0]                               
      Mixed Cell Focus                                 9           17           22            4                                     
      Necrosis                                        19 [1.5]     19 [1.6]      9 [1.7]     14 [1.7]                               
      Bile Duct, Cyst                                               1                                                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          49 [2.1]     46 [2.1]     48 [2.1]     50 [1.5]                               
      Hepatocyte, Multinucleated                       1 [1.0]                   1 [1.0]                                            
      Hepatocyte, Centrilobular, Hypertrophy                       17 [1.3]     31 [1.8]     19 [1.5]                               
      Hepatocyte, Centrilobular, Necrosis                                                     1 [1.0]                               
      Vein, Inflammation                                                                      1 [2.0]                               
   Mesentery                                          (9)          (12)         (8)          (4)                                    
      Inflammation                                     1 [2.0]                   1 [2.0]      1 [1.0]                               
      Fat, Necrosis                                    7 [2.3]      7 [1.9]      7 [2.0]      3 [2.0]                               
   Oral Mucosa                                        (8)          (8)          (5)          (7)                                    
      Gingival, Hyperplasia                                                      1 [4.0]                                            
      Gingival, Inflammation                           8 [1.0]      6 [1.0]      5 [1.8]      5 [1.2]                               
      Pharyngeal, Inflammation                                                                1 [1.0]                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                              1 [3.0]                                                         
      Cyst                                                                                    3 [1.0]                               
      Inflammation                                    14 [1.5]     16 [1.2]      6 [1.0]      9 [1.0]                               
      Metaplasia, Hepatocyte                                                                  1 [1.0]                               
      Acinus, Atrophy                                 20 [1.3]     21 [1.1]     22 [1.3]     10 [1.2]                               
      Acinus, Hyperplasia                              1 [3.0]                                                                      
   Salivary Glands                                    (49)         (50)         (50)         (49)                                   
      Atrophy                                          1 [1.0]      1 [1.0]      3 [1.3]                                            
      Inflammation                                                  2 [3.0]                                                         
   Stomach, Forestomach                               (50)         (49)         (49)         (50)                                   
      Autolysis                                                     1                                                               
      Hyperplasia, Squamous                            7 [2.0]      4 [1.8]     10 [2.4]     17 [2.6]                               
      Inflammation                                     8 [2.0]      6 [2.0]      8 [3.4]     12 [2.6]                               
      Mineralization                                                1 [1.0]      1 [2.0]      3 [2.7]                               
      Ulcer                                            4 [2.5]      1 [1.0]      8 [3.1]      8 [3.0]                               
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Erosion                                          5 [1.4]      2 [2.0]      3 [1.7]      3 [2.3]                               
      Hyperplasia                                                                1 [2.0]                                            
      Inflammation                                     5 [2.2]      5 [1.8]      4 [1.8]      7 [1.7]                               
      Mineralization                                                             5 [2.6]     15 [2.7]                               
      Ulcer                                            1 [3.0]                   1 [3.0]      4 [2.3]                               
   Tooth                                              (3)          (5)          (2)          (3)                                    
      Inflammation                                     1 [1.0]                   1 [1.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Inflammation                                                               1 [1.0]                                            
      Mineralization                                                1 [1.0]      1 [4.0]     11 [3.1]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Pulmonary Artery, Pulmonary Vein, Hypertrophy                              1 [2.0]                                            
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  48 [1.9]     48 [2.0]     47 [2.1]     49 [1.9]                               
      Mineralization                                                             2 [1.5]      6 [2.3]                               
      Aorta, Tunic, Media, Mineralization                           1 [1.0]                                                         
      Atrium, Thrombosis                               3 [3.0]      5 [2.2]      2 [1.5]      1 [1.0]                               
      Endocardium, Hyperplasia                                      2 [4.0]                                                         
      Valve, Thrombosis                                             1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Angiectasis                                      4 [1.0]      4 [1.3]      2 [1.5]      1 [1.0]                               
      Atrophy                                                       1 [3.0]                                                         
      Cytoplasmic Alteration                           1 [2.0]                                                                      
      Degeneration, Cystic                             1 [1.0]                                                                      
      Hematopoietic Cell Proliferation                 5 [1.0]                   2 [1.0]                                            
      Hyperplasia                                      1 [1.0]      4 [1.3]     11 [1.2]      4 [1.3]                               
      Hypertrophy                                      8 [1.4]      2 [1.0]      3 [2.0]      3 [1.0]                               
      Necrosis                                         1 [4.0]      4 [1.8]                   1 [1.0]                               
      Vacuolization Cytoplasmic                       27 [1.6]     27 [1.7]     31 [1.4]     27 [1.4]                               
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Angiectasis                                                   1 [1.0]                                                         
      Hyperplasia                                      6 [2.5]      8 [2.1]     11 [2.1]      5 [1.8]                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 [2.0]                                                                      
   Parathyroid Gland                                  (49)         (45)         (48)         (49)                                   
      Hyperplasia                                      2 [1.5]      1 [1.0]     19 [2.0]     32 [2.2]                               
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                      4 [2.0]     10 [2.0]     11 [2.2]      3 [1.7]                               
      Cyst                                             6 [1.0]      3 [1.0]      1 [1.0]      5 [1.0]                               
      Hyperplasia                                     16 [2.1]     21 [2.3]     12 [1.8]     13 [1.8]                               
      Inflammation                                                  1 [2.0]                   1 [1.0]                               
      Pigmentation, Hemosiderin                                     1 [2.0]                                                         
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mononuclear Cell          1 [1.0]                                                                      
      Ultimobranchial Cyst                                                       2 [1.5]      1 [1.0]                               
      C-Cell, Hyperplasia                             17 [2.0]      8 [2.0]      8 [2.1]      5 [1.4]                               
      Follicle, Cyst                                                1 [2.0]                                                         
      Follicle, Degeneration                           1 [1.0]      2 [1.0]                                                         
      Follicular Cell, Hyperplasia                                  1 [2.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 [1.0]                   1 [1.0]      2 [1.5]                               
      Inflammation                                     3 [2.0]                   4 [1.3]      1 [1.0]                               
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                                                    1 [4.0]                                            
      Hyperplasia                                      1 [3.0]      1 [3.0]                   1 [2.0]                               
      Inflammation                                     2 [4.0]      2 [2.5]      1 [2.0]      1 [2.0]                               
      Duct, Cyst                                                                 1 [2.0]      1 [4.0]                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                          4 [2.3]      7 [1.1]      8 [1.4]      4 [1.3]                               
      Hyperplasia                                      2 [1.0]      3 [1.3]      4 [1.8]                                            
      Inflammation                                    18 [1.6]     17 [1.2]     26 [1.5]     26 [1.6]                               
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                          3 [1.7]      7 [1.0]      8 [1.5]      4 [1.3]                               
      Inflammation                                     1 [3.0]                   1 [3.0]      1 [2.0]                               
      Mineralization                                                                          4 [2.8]                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 [4.0]                   1 [1.0]                               
      Necrosis                                                      2 [4.0]                                                         
      Germinal Epithelium, Degeneration                6 [2.8]      5 [3.6]      6 [2.0]      7 [2.9]                               
      Interstitial Cell, Hyperplasia                  15 [1.9]     12 [2.3]     14 [2.0]     22 [1.9]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Hyperplasia, Megakaryocyte                                    1 [2.0]                                                         
      Inflammation, Granulomatous                                                1 [2.0]      2 [2.0]                               
      Myelofibrosis                                                 1 [2.0]      2 [2.0]      2 [1.0]                               
      Necrosis                                                      1 [2.0]                                                         
      Erythroid Cell, Hyperplasia                     13 [1.8]      3 [1.3]     10 [1.4]     10 [1.7]                               
      Myeloid Cell, Hyperplasia                       21 [2.8]     27 [2.5]     20 [2.8]     14 [2.7]                               
   Lymph Node                                         (19)         (20)         (16)         (19)                                   
      Deep Cervical, Ectasia                           2 [2.0]                                1 [2.0]                               
      Deep Cervical, Infiltration Cellular, Plasma                                                                                  
        Cell                                           1 [2.0]      2 [2.0]                   2 [1.5]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Ectasia                             3 [2.3]                   4 [1.5]      3 [1.0]                               
      Mediastinal, Hemorrhage                          1 [1.0]                   1 [2.0]      2 [2.0]                               
      Mediastinal, Hyperplasia                                                   1 [2.0]      2 [2.0]                               
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                                        1 [2.0]      2 [1.5]      3 [2.0]                               
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                     2 [1.5]                                                                      
      Mediastinal, Inflammation                                                  1 [2.0]                                            
      Pancreatic, Ectasia                                                        2 [1.5]      2 [2.0]                               
      Pancreatic, Hemorrhage                                                     1 [2.0]      1 [1.0]                               
      Pancreatic, Infiltration Cellular, Histiocyte    1 [3.0]      1 [2.0]      2 [3.0]                                            
      Pancreatic, Inflammation                                                   3 [2.3]      1 [3.0]                               
      Renal, Ectasia                                                                          1 [2.0]                               
      Renal, Infiltration Cellular, Histiocyte                                                1 [3.0]                               
   Lymph Node, Mandibular                             (5)          (1)          (2)                                                 
      Ectasia                                          1 [4.0]                                                                      
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 [1.0]                                6 [2.0]                               
      Ectasia                                          4 [2.0]      2 [1.0]      5 [1.6]      4 [1.8]                               
      Infiltration Cellular, Histiocyte               47 [1.2]     41 [1.5]     48 [1.6]     46 [1.5]                               
      Inflammation                                     1 [4.0]                                                                      
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                              1                                                               
      Autolysis                                                     1                                                               
      Fibrosis                                         1 [2.0]                   3 [2.3]      1 [3.0]                               
      Hematopoietic Cell Proliferation                45 [1.2]     42 [1.2]     45 [1.2]     41 [1.2]                               
      Hemorrhage                                                                 1 [1.0]      1 [3.0]                               
      Hyperplasia, Lymphoid                            6 [2.0]      2 [2.0]      9 [2.7]      4 [2.0]                               
      Inflammation, Granulomatous                      1 [2.0]      3 [3.0]      7 [3.3]      1 [4.0]                               
      Necrosis                                         1 [2.0]      2 [2.5]                   1 [2.0]                               
      Pigmentation, Hemosiderin                       39 [1.1]     43 [1.0]     44 [1.0]     43 [1.0]                               
      Lymphoid Follicle, Atrophy                       1 [1.0]                   1 [2.0]      2 [2.5]                               
   Thymus                                             (48)         (48)         (48)         (48)                                   
      Atrophy                                         44 [3.6]     42 [3.6]     47 [3.8]     46 [3.8]                               
      Ectopic Parathyroid Gland                                     1 [3.0]                   4 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (50)                                   
      Fibrosis                                         1 [3.0]                                                                      
      Galactocele                                      2 [1.0]                   1 [1.0]                                            
      Inflammation                                     1 [3.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 [2.0]                                                         
      Inflammation                                     2 [1.5]                                                                      
      Subcutaneous Tissue, Inflammation                             1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                                     1 [2.0]      4 [1.8]                               
      Osteosclerosis                                                             1 [2.0]                                            
   Skeletal Muscle                                    (2)          (2)          (1)                                                 
      Degeneration                                     1 [2.0]      1 [2.0]      1 [2.0]                                            
      Inflammation                                     1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       5 [1.8]      5 [1.8]      2 [2.5]      5 [2.2]                               
      Necrosis                                         2 [2.0]      4 [1.8]                                                         
   Peripheral Nerve                                   (1)                                                                           
      Infiltration Cellular, Mononuclear Cell          1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)                                   
      Inflammation, Acute                              2 [1.0]      2 [2.0]      5 [1.2]      7 [1.3]                               
      Inflammation, Granulomatous                      2 [1.0]      4 [2.3]      5 [2.0]      2 [2.0]                               
      Metaplasia, Squamous                                                                    1 [1.0]                               
      Mineralization                                                             2 [2.5]     10 [2.7]                               
      Necrosis                                         1 [2.0]                                                                      
      Thrombosis                                                    1 [2.0]      1 [3.0]                                            
      Alveolar Epithelium, Hyperplasia                16 [1.4]      5 [2.0]     13 [1.6]      7 [1.3]                               
      Alveolus, Infiltration Cellular, Histiocyte     46 [1.7]     47 [1.5]     49 [1.5]     50 [1.8]                               
      Bronchiole, Hyperplasia                          1 [1.0]      3 [2.0]                                                         
      Interstitium, Fibrosis                                        2 [1.5]                                                         
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation                                     7 [2.0]      7 [1.9]      8 [1.9]      9 [1.9]                               
      Thrombosis                                       1 [2.0]      2 [3.0]      1 [3.0]                                            
      Olfactory Epithelium, Degeneration               1 [1.0]                                                                      
      Olfactory Epithelium, Metaplasia                 1 [2.0]                   1 [1.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/21/03    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 16:01:01    
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         FISCHER 344 RATS MALE                        0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
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RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Hyperplasia              1 [2.0]                   1 [1.0]                                            
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Inflammation                                     2 [1.0]      1 [1.0]      8 [1.0]      3 [2.3]                               
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Anterior Chamber, Inflammation                                                          1 [3.0]                               
      Ciliary Body, Inflammation                                                 1 [1.0]                                            
      Cornea, Inflammation                                                                    1 [1.0]                               
      Iris, Fibrosis                                   1 [3.0]                   1 [3.0]                                            
      Iris, Inflammation                               1 [1.0]                                1 [2.0]                               
      Lens, Cataract                                   2 [3.0]                   1 [4.0]                                            
      Lens, Mineralization                             1 [2.0]                                                                      
      Retina, Atrophy                                  1 [2.0]                                                                      
      Retina, Degeneration                             5 [2.2]      2 [1.0]      5 [1.8]                                            
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 [1.0]                   1 [3.0]      1 [1.0]                               
      Infiltration Cellular, Lymphoid                  9 [1.2]      4 [1.0]      9 [1.0]      3 [1.0]                               
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                    4 [1.8]      1 [2.0]      4 [1.5]      2 [2.5]                               
      Hyperplasia, Oncocytic                                                     1 [2.0]                                            
      Infarct                                          1            3                                                               
      Nephropathy                                     50 [1.3]     45 [2.4]     50 [3.3]     50 [3.8]                               
      Artery, Inflammation                                                                    1 [2.0]                               
      Cortex, Mineralization                                        1 [1.0]      4 [2.5]     14 [2.8]                               
      Medulla, Mineralization                         47 [1.0]     49 [1.2]     47 [1.1]     49 [1.2]                               
      Papilla, Transitional Epithelium, Hyperplasia                                           1 [1.0]                               
      Pelvis, Inflammation                                                       1 [1.0]      1 [2.0]                               
      Pelvis, Transitional Epithelium, Hyperplasia     1 [1.0]     11 [1.2]     29 [1.5]     34 [1.7]                               
      Renal Tubule, Cyst                                                         1            9                                     
      Renal Tubule, Hyperplasia                        1 [1.0]      5 [1.4]     20 [1.5]     23 [1.3]                               
      Renal Tubule, Pigmentation                       1 [4.0]      1 [1.0]      2 [3.0]                                            
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Calculus Gross Observation                                    1            1                                                  
      Inflammation                                     3 [1.7]                   2 [2.5]      2 [1.5]                               
      Muscularis, Degeneration                         1 [1.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
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