National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19865

TDMS Study 88138-04 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                    BENZOPHENONE                                              DATE: 06/24/03  
EXPERIMENT: 88138 TEST: 04                                                                                        TIME: 09:24:15    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C88138B     
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                BENZOPHENONE                                                DATE: 06/24/03    
EXPERIMENT: 88138 TEST: 04                                                                                        TIME:  9:32:45    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  88138B      
CONT: N01-ES-55388                                                                                                CAS: 119-61-9     
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                                CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                            
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     5.0    23.3       5.6     23.1    1.12       76      5.2     22.9    1.04      143      4.9     23.3    0.98      261       
  2     5.2    23.9       6.5     24.2    1.25       84      6.0     23.9    1.15      156      5.3     24.0    1.02      277       
  3     4.7    25.2       5.2     24.6    1.11       66      5.3     25.0    1.13      134      4.9     25.1    1.04      245       
  6     4.9    28.5       5.1     28.7    1.04       55      4.9     28.5    1.00      107      4.9     28.3    1.00      217       
 10     4.9    32.0       5.2     31.8    1.06       52      5.0     31.7    1.02       99      5.1     31.3    1.04      204       
 14     5.2    34.9       5.0     34.4    0.96       46      5.1     35.3    0.98       91      5.0     33.9    0.96      183       
 18     4.8    37.4       5.1     37.5    1.06       42      5.0     36.9    1.04       85      5.2     35.9    1.08      180       
 22     4.8    38.9       4.8     38.0    1.00       39      4.8     38.5    1.00       77      5.0     38.3    1.04      162       
 26     5.0    40.9       5.4     40.2    1.08       42      5.0     41.0    1.00       76      5.1     40.6    1.02      158       
 30     4.5    41.6       4.6     41.3    1.02       35      4.4     41.6    0.98       66      4.4     41.4    0.98      133       
 34     5.1    43.1       5.2     42.9    1.02       38      4.8     41.6    0.94       73      5.1     41.9    1.00      151       
 37     5.1    43.6       5.2     43.3    1.02       37      5.0     42.9    0.98       73      5.1     42.2    1.00      151       
 42     4.8    44.6       4.9     43.9    1.02       35      4.9     44.1    1.02       69      4.7     43.2    0.98      137       
 46     4.9    45.0       4.7     44.4    0.96       33      4.9     44.0    1.00       69      4.8     43.6    0.98      137       
 50     4.8    46.0       5.2     45.8    1.08       35      5.0     45.0    1.04       70      4.9     45.0    1.02      137       
 54     4.8    45.7       5.1     44.9    1.06       36      5.0     44.1    1.04       71      4.8     44.6    1.00      134       
 58     5.3    45.9       5.4     44.7    1.02       37      5.2     44.4    0.98       74      5.2     45.6    0.98      142       
 62     5.0    45.9       5.2     44.7    1.04       36      4.9     45.4    0.98       67      5.1     45.8    1.02      138       
 66     4.9    44.1       5.0     44.8    1.02       35      5.0     45.4    1.02       69      4.8     45.3    0.98      133       
 70     4.8    43.8       4.9     44.3    1.02       34      4.9     44.8    1.02       69      4.5     44.7    0.94      126       
 74     4.9    44.0       5.2     45.0    1.06       36      5.1     44.9    1.04       71      5.1     45.2    1.04      141       
 78     5.1    43.1       5.3     44.1    1.04       38      5.1     44.5    1.00       71      4.9     43.8    0.96      140       
 84     5.2    40.7       5.3     40.8    1.02       41      5.3     40.9    1.02       81      5.4     40.4    1.04      168       
 86     5.1    41.7       5.2     41.5    1.02       39      5.2     42.2    1.02       76      5.2     41.3    1.02      156       
 90     5.0    41.9       5.2     41.7    1.04       39      4.9     41.7    0.98       74      4.9     41.3    0.98      149       
 94     5.2    41.4       5.1     40.8    0.98       39      5.0     41.0    0.96       76      5.1     39.8    0.98      161       
 98     4.5    41.2       4.9     39.8    1.09       38      4.7     40.3    1.04       73      4.9     39.5    1.09      155       
102     4.6    40.3       4.7     39.5    1.02       37      4.6     40.3    1.00       71      4.4     38.4    0.96      142       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.9    26.6       5.5     26.5    1.12       67      5.3     26.4    1.07      128      5.0     26.4    1.02      241       
SD(D)   0.2               0.6             0.08       14      0.4             0.07       24      0.2             0.03       30       
CV(E)   3.6              10.8             7.3      20.7      8.0             6.4      18.8      3.9             2.6      12.6       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.9    41.6       5.0     41.2    1.02       38      4.9     41.1    1.00       75      4.9     40.6    1.01      153       
SD(D)   0.2               0.2             0.04        4      0.2             0.03        8      0.2             0.04       18       
CV(E)   4.2               4.7             4.2      10.1      4.3             3.1      10.4      4.7             3.6      11.7       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.9    43.1       5.1     42.8    1.03       37      5.0     43.1    1.01       73      4.9     42.8    1.00      145       
SD(D)   0.2               0.2             0.03        2      0.2             0.03        4      0.3             0.04       12       
CV(E)   4.9               3.8             2.6       4.8      4.1             2.7       5.2      5.8             4.2       8.4       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                                CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                            
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.7    18.8       3.8     18.6     1.03      63      3.6     18.6     0.97     122      3.5     18.5     0.95     233       
  2     3.8    19.1       3.7     19.5     0.97      60      3.8     18.6     1.00     128      3.6     19.5     0.95     228       
  6     3.6    22.5       3.5     22.4     0.97      48      3.7     22.7     1.03     101      3.7     22.8     1.03     204       
 10     3.8    25.0       3.6     25.7     0.95      44      3.7     24.0     0.97      96      4.0     25.7     1.05     197       
 14     3.8    27.2       4.0     28.4     1.05      44      3.9     26.9     1.03      92      4.0     28.0     1.05     181       
 18     3.6    29.5       3.9     30.8     1.08      39      3.8     30.3     1.06      79      4.0     30.3     1.11     164       
 22     4.3    32.8       4.9     33.7     1.14      45      4.6     33.3     1.07      86      4.5     32.2     1.05     173       
 26     4.1    33.2       4.0     35.1     0.98      36      4.3     33.6     1.05      80      4.0     33.0     0.98     150       
 30     3.8    35.3       4.2     36.6     1.11      36      3.9     35.5     1.03      69      3.7     34.4     0.97     136       
 34     3.8    36.5       4.1     38.0     1.08      34      3.8     36.9     1.00      64      3.8     35.1     1.00     134       
 37     3.8    38.3       4.2     39.7     1.11      33      3.9     38.0     1.03      64      3.9     36.2     1.03     133       
 42     3.8    39.8       4.1     40.6     1.08      31      3.7     39.3     0.97      59      3.7     37.2     0.97     125       
 46     3.6    41.2       3.7     42.0     1.03      27      3.5     40.0     0.97      54      3.4     37.2     0.94     114       
 50     4.0    41.8       3.9     42.9     0.98      28      3.8     41.1     0.95      58      3.9     37.6     0.98     128       
 54     3.6    43.3       3.8     42.8     1.06      28      3.6     41.4     1.00      55      4.1     37.2     1.14     136       
 58     4.1    43.7       4.2     43.5     1.02      30      3.8     40.2     0.93      58      4.1     37.8     1.00     135       
 62     3.9    44.6       3.9     43.5     1.00      28      3.9     41.4     1.00      59      3.8     37.9     0.97     125       
 66     4.1    44.4       3.8     43.1     0.93      27      3.9     41.4     0.95      58      3.8     38.5     0.93     125       
 70     4.0    44.4       4.0     43.3     1.00      29      4.0     41.7     1.00      59      4.0     38.9     1.00     130       
 74     4.2    45.6       4.5     44.2     1.07      32      4.4     42.2     1.05      65      4.4     39.4     1.05     140       
 78     4.9    46.2       5.0     43.8     1.02      36      5.1     41.5     1.04      77      4.8     39.5     0.98     151       
 84     3.8    43.5       4.1     41.4     1.08      31      4.1     39.5     1.08      65      4.5     37.4     1.18     149       
 86     4.3    43.9       4.2     42.0     0.98      32      4.7     41.0     1.09      71      4.4     37.8     1.02     146       
 90     4.2    44.4       4.0     41.1     0.95      31      4.0     40.6     0.95      61      4.1     38.4     0.98     133       
 94     3.9    44.4       4.1     41.1     1.05      31      4.1     41.1     1.05      63      4.2     38.6     1.08     136       
 98     3.8    45.1       4.0     41.3     1.05      30      4.2     41.4     1.11      63      4.0     38.4     1.05     131       
102     3.5    43.5       3.8     40.4     1.09      29      3.9     40.2     1.11      60      3.8     37.2     1.09     126       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.7    21.3       3.7     21.6     0.98      54      3.7     21.0     0.99     112      3.7     21.6     0.99     215       
SD(D)   0.1               0.1              0.03       9      0.1              0.03      16      0.3              0.05      18       
CV(E)   2.5               3.9              3.4     17.2      2.1              2.6     13.9      6.9              5.5      8.4       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    3.8    35.6       4.1     36.8     1.06      35      3.9     35.5     1.01      70      3.9     34.1     1.01     144       
SD(D)   0.2               0.3              0.05       6      0.3              0.04      13      0.3              0.05      22       
CV(E)   5.7               7.9              5.2     17.1      7.8              3.9     18.2      7.1              5.0     15.4       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.0    44.4       4.1     42.4     1.02      30      4.1     41.1     1.03      63      4.2     38.2     1.04     136       
SD(D)   0.3               0.3              0.05       2      0.4              0.06       6      0.3              0.07       9       
CV(E)   8.4               8.3              4.9      7.4      9.9              6.0      9.6      7.1              7.0      6.5       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                 
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               23.3  50                 23.1  50                 22.9  50                 23.3  50                               
  1   5.0  3583   23.3  50     5.6  3505   23.1  50     5.2  3516   22.9  50     4.9  3510   23.3  50                               
  2   5.2  8310   23.9  50     6.5  8094   24.2  50     6.0  8229   23.9  50     5.3  8216   24.0  50                               
  3   4.7  4805   25.2  50     5.2  4819   24.6  50     5.3  4627   25.0  50     4.9  4802   25.1  50                               
  5   4.8  3733                5.4  3532                5.4  3566                5.4  3651                                          
  6   4.9  4735   28.5  50     5.1  4781   28.7  50     4.9  4785   28.5  50     4.9  4926   28.3  50                               
  9   5.1  3646                5.3  3594                5.0  3474                5.2  3455                                          
 10   4.9  4772   32.0  50     5.2  4745   31.8  50     5.0  4781   31.7  50     5.1  4695   31.3  50                               
 13   5.1  3776                5.3  3679                5.6  3353                5.3  3406                                          
 14   5.2  4648   34.9  50     5.0  4536   34.4  50     5.1  4819   35.3  50     5.0  4584   33.9  50                               
 17   5.0  3314                5.1  3424                4.6  3416                4.7  3494                                          
 18   4.8  4715   37.4  50     5.1  4637   37.5  50     5.0  4800   36.9  50     5.2  4444   35.9  50                               
 21   4.7  3574                4.9  3350                5.0  3576                4.8  3588                                          
 22   4.8  4784   38.9  50     4.8  5035   38.0  50     4.8  4936   38.5  50     5.0  4917   38.3  50                               
 25   4.6  3355                5.0  3420                5.2  2795                5.3  2040                                          
 26   5.0  4482   40.9  50     5.4  4487   40.2  50     5.0  4599   41.0  50     5.1  4706   40.6  50                               
 29   4.6  3551                5.3  3514                5.6  3314                5.7  3309                                          
 30   4.5  4656   41.6  50     4.6  4565   41.3  50     4.4  4927   41.6  50     4.4  4862   41.4  50                               
 33   5.4  3360                5.7  3445                5.0  3721                5.3  3670                                          
 34   5.1  4738   43.1  50     5.2  4660   42.9  50     4.8  4691   41.6  50     5.1  4849   41.9  50                               
 36   5.0  3656                5.4  3577                5.6  3110                5.9  3048                                          
 37   5.1  4684   43.6  50     5.2  4481   43.3  50     5.0  4838   42.9  50     5.1  4825   42.2  50                               
 41   5.1  3512                5.2  3479                5.2  3241                5.1  3497                                          
 42   4.8  4822   44.6  50     4.9  4736   43.9  50     4.9  4838   44.1  50     4.7  4789   43.2  50                               
 45   5.4  3525                5.2  3484                5.3  3564                5.2  3623                                          
 46   4.9  4800   45.0  50     4.7  4530   44.4  50     4.9  4791   44.0  50     4.8  4749   43.6  50                               
 49   5.2  3528                5.4  3600                5.1  3511                4.9  3537                                          
 50   4.8  4750   46.0  50     5.2  4766   45.8  50     5.0  4868   45.0  50     4.9  4766   45.0  50                               
 53   4.9  3638                5.1  3577                5.0  3538                4.9  3384                                          
 54   4.8  4744   45.7  50     5.1  4655   44.9  50     5.0  4704   44.1  50     4.8  4776   44.6  50                               
 57   4.9  3587                5.0  3757                4.8  3687                4.9  3605                                          
 58   5.3  4200   45.9  50     5.4  4105   44.7  50     5.2  4374   44.4  50     5.2  4307   45.6  50                               
 61   5.2  3578                5.5  3664                5.2  3619                5.1  3700                                          
 62   5.0  4756   45.9  50     5.2  4583   44.7  50     4.9  4759   45.4  50     5.1  4806   45.8  50                               
 65   5.1  3604                5.3  3456                5.4  3600                5.3  3627                                          
 66   4.9  4707   44.1  50     5.0  4642   44.8  49     5.0  4864   45.4  50     4.8  4895   45.3  50                               
 69   5.0  3568                5.5  3358                5.3  3235                5.4  3413                                          
 70   4.8  4460   43.8  49     4.9  4608   44.3  49     4.9  4803   44.8  50     4.5  5005   44.7  50                               
 73   5.0  3552                5.6  3552                5.3  3659                5.2  3632                                          
 74   4.9  4665   44.0  49     5.2  4567   45.0  49     5.1  4793   44.9  50     5.1  4835   45.2  50                               
 77   5.0  3380                5.4  3456                5.2  3604                5.3  3562                                          
 78   5.1  4537   43.1  48     5.3  4656   44.1  49     5.1  4925   44.5  50     4.9  4937   43.8  50                               
 83   4.9  3417                5.2  3393                5.0  3467                5.2  3415                                          
 84   5.2  4630   40.7  48     5.3  4599   40.8  48     5.3  4766   40.9  50     5.4  4566   40.4  49                               
 85   5.8  3291                5.8  3224                5.7  3305                5.5  3422                                          
 86   5.1  4581   41.7  48     5.2  4500   41.5  47     5.2  4586   42.2  48     5.2  4599   41.3  49                               
 89   5.1  3454                5.2  3240                4.9  3472                5.0  3530                                          
 90   5.0  4622   41.9  48     5.2  4329   41.7  45     4.9  4622   41.7  48     4.9  4523   41.3  48                               
 93   5.1  3458                5.4  3168                5.1  3384                4.9  3488                                          
 94   5.2  4512   41.4  48     5.1  4348   40.8  45     5.0  4706   41.0  48     5.1  4767   39.8  48                               
=========================================================================================================                           
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                 
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS                              
==========================================================================================================                          
 97   5.0  3368                5.1  3196                4.9  3302                4.9  3345                                          
 98   4.5  4365   41.2  46     4.9  4268   39.8  45     4.7  4467   40.3  46     4.9  4450   39.5  47                               
101   4.8  3135                4.7  2981                4.9  3128                4.9  3112                                          
102   4.6  4153   40.3  44     4.7  4086   39.5  44     4.6  4383   40.3  45     4.4  4333   38.4  45                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           26.6                     26.5                     26.4                     26.4                                   
14 TO 52          41.6                     41.2                     41.1                     40.6                                   
 > 52             43.1                     42.8                     43.1                     42.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                               
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               18.8  50                 18.6  50                 18.6  50                 18.5  50                               
  1   3.7  3614   18.8  50     3.8  3582   18.6  50     3.6  3615   18.6  50     3.5  3615   18.5  50                               
  2   3.8  4740   19.1  50     3.7  4730   19.5  50     3.8  4729   18.6  50     3.6  4723   19.5  50                               
  5   4.0  3686                3.9  3690                3.8  3690                3.8  3685                                          
  6   3.6  4863   22.5  50     3.5  4872   22.4  50     3.7  4885   22.7  50     3.7  4894   22.8  50                               
  9   4.0  3600                3.9  3608                3.8  3618                3.5  3620                                          
 10   3.8  4759   25.0  50     3.6  4271   25.7  50     3.7  4259   24.0  50     4.0  4713   25.7  50                               
 13   3.7  3739                3.9  3349                3.9  3710                3.9  3343                                          
 14   3.8  4329   27.2  50     4.0  4781   28.4  50     3.9  4748   26.9  50     4.0  4715   28.0  50                               
 17   3.6  3730                3.8  3725                3.8  3395                3.6  3816                                          
 18   3.6  4827   29.5  50     3.9  4827   30.8  50     3.8  4777   30.3  50     4.0  4717   30.3  50                               
 21   3.4  3720                3.8  3724                3.5  3723                3.6  3722                                          
 22   4.3  4643   32.8  50     4.9  4632   33.7  50     4.6  4655   33.3  50     4.5  4717   32.2  50                               
 25   3.0  3465                3.6  3860                3.7  3835                3.5  3807                                          
 26   4.1  4544   33.2  50     4.0  4578   35.1  50     4.3  4611   33.6  50     4.0  4644   33.0  50                               
 29   4.3  3520                4.4  3525                4.1  3520                4.5  3523                                          
 30   3.8  4842   35.3  50     4.2  4863   36.6  50     3.9  4874   35.5  50     3.7  4899   34.4  50                               
 33   4.0  3660                3.7  3660                4.0  3584                3.9  3655                                          
 34   3.8  4799   36.5  50     4.1  4833   38.0  50     3.8  4749   36.9  49     3.8  4891   35.1  50                               
 36   4.1  3677                4.0  3677                4.2  3572                4.4  3605                                          
 37   3.8  4764   38.3  50     4.2  4777   39.7  50     3.9  4726   38.0  49     3.9  4922   36.2  50                               
 41   4.3  3599                4.8  3600                4.4  3528                4.1  3600                                          
 42   3.8  4735   39.8  50     4.1  4752   40.6  50     3.7  4671   39.3  49     3.7  4784   37.2  50                               
 45   4.4  3510                4.4  3506                4.3  3434                4.4  3505                                          
 46   3.6  4865   41.2  50     3.7  4877   42.0  49     3.5  4841   40.0  49     3.4  4965   37.2  50                               
 49   4.7  3585                4.5  3509                4.5  3557                4.4  3640                                          
 50   4.0  4827   41.8  50     3.9  4738   42.9  49     3.8  4712   41.1  49     3.9  4825   37.6  50                               
 53   4.0  3637                4.5  3568                4.1  3567                4.0  3567                                          
 54   3.6  4799   43.3  50     3.8  4714   42.8  49     3.6  4748   41.4  49     4.1  4780   37.2  49                               
 57   4.6  3511                4.7  3438                4.4  3080                4.5  3425                                          
 58   4.1  4862   43.7  50     4.2  4697   43.5  49     3.8  4206   40.2  49     4.1  4671   37.8  48                               
 61   4.2  3597                4.7  3597                4.3  3597                4.1  3527                                          
 62   3.9  4647   44.6  49     3.9  4663   43.5  49     3.9  4681   41.4  49     3.8  4603   37.9  48                               
 65   4.2  3578                4.3  3639                4.2  3606                4.0  3444                                          
 66   4.1  4671   44.4  48     3.8  4670   43.1  49     3.9  4692   41.4  49     3.8  4462   38.5  47                               
 69   4.2  3638                4.1  3695                3.8  3631                4.0  3440                                          
 70   4.0  4445   44.4  48     4.0  4573   43.3  49     4.0  4513   41.7  48     4.0  4354   38.9  46                               
 73   4.6  3470                4.5  3538                4.2  3468                4.2  3323                                          
 74   4.2  4627   45.6  48     4.5  4742   44.2  49     4.4  4662   42.2  48     4.4  4117   39.4  46                               
 77   4.4  3676                4.4  3671                4.3  3669                4.3  3517                                          
 78   4.9  4418   46.2  48     5.0  3978   43.8  48     5.1  4465   41.5  48     4.8  4224   39.5  45                               
 81   3.8  3455                4.2  3388                4.1  3384                4.2  3240                                          
 83   4.4  3305                4.8  3233                4.7  3233                4.6  3095                                          
 84   3.8  4643   43.5  48     4.1  4587   41.4  47     4.1  4604   39.5  47     4.5  4422   37.4  45                               
 85   4.6  3494                4.9  3421                4.9  3430                4.6  3285                                          
 86   4.3  4432   43.9  48     4.2  4330   42.0  46     4.7  4370   41.0  47     4.4  4338   37.8  45                               
 89   4.6  3168                4.8  3312                4.7  3384                4.6  3171                                          
 90   4.2  4270   44.4  44     4.0  4478   41.1  46     4.0  4644   40.6  47     4.1  4372   38.4  44                               
 93   4.6  3158                4.8  3230                4.8  3231                4.7  2655                                          
 94   3.9  4350   44.4  44     4.1  4475   41.1  45     4.1  4500   41.1  45     4.2  4082   38.6  40                               
=========================================================================================================                           
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                               
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS                              
==========================================================================================================                          
 97   4.5  3105                4.6  3175                4.9  3176                4.8  2726                                          
 98   3.8  4234   45.1  44     4.0  4340   41.3  45     4.2  4360   41.4  45     4.0  3620   38.4  37                               
101   4.0  3064                4.3  3048                4.1  3015                4.2  2628                                          
102   3.5  4241   43.5  44     3.8  4164   40.4  43     3.9  4077   40.2  42     3.8  3115   37.2  35                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           21.3                     21.6                     21.0                     21.6                                   
14 TO 52          35.6                     36.8                     35.5                     34.1                                   
 > 52             44.4                     42.4                     41.1                     38.2                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.