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TDMS Study 99022-02 Pathology Tables

NTP  EXP/TEST: 99022-02                     AZT TRANSPLACENTAL CARCINOGENESIS STUDY                               PAGE: 1
TEST TYPE: PERINATAL EXPOS                      INITIAL AND CURRENT BODY WEIGHT                                   DATE: 10/08/03
ROUTE: IN-UTERO                                                                                                   TIME: 16:02:30

                                                         EIS REPORT 03
                                                           FINAL/MICE


       FACILITY:  Southern Research Institute

       NTP C#:  C99022

       CONTRACT NUMBER:  N01-ES-15328

       CAS NUMBER:  30516-87-1

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       MERGE     001   001,011                  0       MG/KG/DY
                               MERGE     002   002,012                  50      MG/KG/DY
                               MERGE     003   003,013                  100     MG/KG/DY
                               MERGE     004   004,014                  200     MG/KG/DY
                               MERGE     005   005,015                  300     MG/KG/DY
                               MERGE     006   006,016                  0       MG/KG/DY
                               MERGE     007   007,017                  50      MG/KG/DY
                               MERGE     008   008,018                  100     MG/KG/DY
                               MERGE     009   009,019                  200     MG/KG/DY
                               MERGE     010   010,020                  300     MG/KG/DY

NTP  EXP/TEST: 99022-02                     AZT TRANSPLACENTAL CARCINOGENESIS STUDY                               PAGE: 2
TEST TYPE: PERINATAL EXPOS                      INITIAL AND CURRENT BODY WEIGHT                                   DATE: 10/08/03
ROUTE: IN-UTERO                                             EISRPT03                                              TIME: 16:02:30
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 SPECIES-STRAIN: SWISS-MICE                 SEX: FEMALE      WEEK ON DOSE: 97     FIRST DOSE: 06/19/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0       MG/KG/DY   50     21.8    3.6        19     55.3    9.1                     19     34.2    8.4

 50      MG/KG/DY   50     21.1    3.6        17     58.2    8.9       105.2         17     36.7   10.3

 100     MG/KG/DY   50     21.3    4.2        24     57.6   11.7       104.1         24     36.6   11.6

 200     MG/KG/DY   40     22.3    2.0        19     51.1    8.2        92.4         19     28.8    7.8

 300     MG/KG/DY   42     19.4    2.4        18     59.7   16.4       107.9         18     39.5   15.1




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 SPECIES-STRAIN: SWISS-MICE                 SEX: MALE        WEEK ON DOSE: 97     FIRST DOSE: 06/19/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0       MG/KG/DY   50     28.5    4.0        19     55.5    5.2                     19     26.9    5.3

 50      MG/KG/DY   50     28.1    5.8        20     52.1    8.1        93.8         20     25.7    7.9

 100     MG/KG/DY   50     26.9    3.6        13     53.8    7.8        96.9         13     26.1    7.9

 200     MG/KG/DY   37     26.9    2.7         7     49.9    5.7        89.9          7     23.2    6.5

 300     MG/KG/DY   32     25.6    4.2         7     54.9    5.4        98.9          7     29.2    2.9

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