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TDMS Study 99022-02 Pathology Tables

NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53

                                                   FINAL #2; REVISION #1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-87-1

       Lock Date:  06/20/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Merge     006   006,016
                               Merge     007   007,017
                               Merge     008   008,018
                               Merge     009   009,019
                               Merge     010   010,020
                               Merge     001   001,011
                               Merge     002   002,012
                               Merge     003   003,013
                               Merge     004   004,014
                               Merge     005   005,015
























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                            0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           40           42                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           18           11           11           15                        
    Natural Death                                     14           13           15            9            8                        
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                   1                        
    Terminal Sacrifice                                19           17           24           19           18                        
    Natural Death                                                   1                         1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           40           42                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (49)         (49)         (39)         (42)                      
      Edema                                                         1 [2.0]      1 [2.0]                   1 [2.0]                  
   Intestine Large, Cecum                             (47)         (48)         (45)         (38)         (40)                      
      Amyloid Deposition                               1 [2.0]                                                                      
      Edema                                            3 [2.0]      3 [2.7]      4 [2.3]      4 [2.5]      8 [2.3]                  
   Intestine Small, Duodenum                          (50)         (50)         (48)         (40)         (42)                      
      Amyloid Deposition                               1 [3.0]                                                                      
      Erosion                                          1 [2.0]      1 [2.0]                                2 [3.0]                  
      Ulcer                                                                      2 [3.5]                   1 [3.0]                  
      Epithelium, Hyperplasia                         12 [2.1]      7 [2.3]     12 [2.4]      4 [2.0]      9 [2.0]                  
   Intestine Small, Jejunum                           (46)         (49)         (46)         (40)         (40)                      
      Amyloid Deposition                               1 [3.0]                                                                      
      Epithelium, Hyperplasia                                       1 [2.0]      1 [2.0]                   1 [2.0]                  
   Intestine Small, Ileum                             (47)         (48)         (45)         (38)         (40)                      
      Amyloid Deposition                               1 [3.0]                                                                      
   Liver                                              (50)         (50)         (50)         (40)         (42)                      
      Amyloid Deposition                               1 [3.0]                                1 [4.0]                               
      Angiectasis                                      1 [3.0]                                                                      
      Basophilic Focus                                                           1                         1                        
      Cyst                                             2                         1            1                                     
      Eosinophilic Focus                               1            2            3            1            3                        
      Hematopoietic Cell Proliferation                 8 [3.0]      5 [3.4]      5 [2.8]      5 [3.0]      8 [2.5]                  
      Hyperplasia, Lymphoid                                                                   3 [2.0]                               
      Infiltration Cellular, Mixed Cell                7 [2.0]      6 [2.5]      6 [2.0]      9 [2.3]      9 [2.1]                  
      Necrosis, Focal                                  6 [2.2]      8 [2.5]      5 [2.4]      4 [2.3]      6 [2.0]                  
      Regeneration                                                  1 [3.0]                                1 [3.0]                  
      Thrombosis                                       1                                                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                            0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hypertrophy                          1 [2.0]      6 [2.2]      3 [2.0]      2 [2.5]      2 [2.5]                  
      Hepatocyte, Vacuolization Cytoplasmic                         1 [4.0]      3 [2.7]                   2 [3.0]                  
      Kupffer Cell, Hyperplasia                        1 [3.0]                   1 [3.0]      1 [3.0]      2 [2.0]                  
      Kupffer Cell, Pigmentation                       4 [2.0]      4 [2.3]      2 [2.5]      6 [2.3]      6 [2.0]                  
   Mesentery                                          (4)          (8)          (7)          (3)          (5)                       
      Angiectasis                                                                1 [3.0]                                            
      Hemorrhage                                       1 [4.0]      1 [3.0]                   1 [4.0]                               
      Thrombosis                                       1                                                                            
      Fat, Necrosis                                                 5 [3.4]      4 [3.5]      2 [4.0]      3 [3.7]                  
   Pancreas                                           (50)         (49)         (49)         (40)         (41)                      
      Atrophy                                                       1 [2.0]                   1 [3.0]                               
      Edema                                                         2 [2.0]      1 [2.0]                   1 [2.0]                  
      Necrosis, Focal                                  1 [3.0]                                                                      
      Acinus, Cytoplasmic Alteration                                4 [3.0]                   2 [3.0]      4 [3.3]                  
   Salivary Glands                                    (50)         (49)         (49)         (40)         (42)                      
      Hyperplasia, Lymphoid                            2 [2.5]      6 [2.0]      3 [2.0]      1 [2.0]      4 [2.3]                  
   Stomach, Forestomach                               (50)         (50)         (49)         (40)         (42)                      
      Edema                                            1 [2.0]      5 [2.2]      3 [2.0]      2 [2.5]      4 [2.3]                  
      Erosion                                                                                              2 [1.5]                  
      Epithelium, Hyperplasia                          4 [1.5]      3 [1.0]                   2 [2.0]      4 [1.5]                  
   Stomach, Glandular                                 (50)         (50)         (49)         (40)         (42)                      
      Amyloid Deposition                               1 [2.0]                                                                      
      Cyst                                                          2                                                               
      Edema                                                         2 [2.0]      1 [2.0]                   2 [2.5]                  
      Erosion                                          1 [2.0]      2 [2.0]      1 [3.0]                                            
      Infiltration Cellular, Mixed Cell                                                                    1 [1.0]                  
      Glands, Hyperplasia, Cystic                      6 [2.3]     12 [2.3]      8 [2.3]     10 [2.3]      6 [2.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (2)                                                 
      Inflammation, Chronic                            1 [2.0]                                                                      
   Heart                                              (50)         (49)         (50)         (40)         (42)                      
      Amyloid Deposition                               1 [2.0]                                                                      
      Cardiomyopathy                                   3 [1.7]      2 [1.5]      6 [1.2]      1 [2.0]      2 [1.5]                  
      Inflammation, Chronic                            7 [2.0]      1 [3.0]      2 [2.0]      2 [2.5]      2 [2.0]                  
      Mineralization                                   2 [3.0]      3 [2.0]      2 [1.0]      1 [1.0]      2 [2.5]                  
      Thrombosis                                                                 3                         1                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                            0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Cortex                                     (50)         (49)         (50)         (38)         (42)                      
      Accessory Adrenal Cortical Nodule               10 [3.0]      8 [3.0]     11 [3.0]      7 [3.0]      6 [3.0]                  
      Amyloid Deposition                               1 [3.0]                                                                      
      Hyperplasia, Diffuse                                          2 [2.0]                                1 [2.0]                  
      Hypertrophy, Focal                                                                                   1 [3.0]                  
      Capsule, Hyperplasia                             1 [2.0]      1 [3.0]                   2 [2.0]      2 [2.5]                  
   Adrenal Medulla                                    (50)         (49)         (50)         (38)         (42)                      
      Hyperplasia                                      1 [1.0]      3 [1.0]      1 [1.0]                                            
   Islets, Pancreatic                                 (50)         (49)         (49)         (40)         (41)                      
      Hyperplasia                                      2 [1.0]      5 [2.2]      6 [1.8]      7 [1.9]     10 [1.8]                  
   Pituitary Gland                                    (50)         (49)         (50)         (40)         (42)                      
      Pars Distalis, Angiectasis                                                 1 [2.0]      1 [2.0]      2 [2.5]                  
      Pars Distalis, Cyst                              3                                      3                                     
      Pars Distalis, Hyperplasia, Focal                3 [1.7]      4 [2.0]      1 [3.0]      2 [2.5]      4 [2.0]                  
      Pars Intermedia, Hyperplasia                     1 [3.0]                   1 [3.0]                                            
   Thyroid Gland                                      (50)         (49)         (50)         (40)         (42)                      
      Amyloid Deposition                               1 [3.0]                                1 [2.0]                               
      Degeneration, Cystic                            26 [2.1]     18 [2.6]     39 [2.3]     24 [1.7]     29 [2.4]                  
      Follicular Cell, Hyperplasia                     4 [1.3]      2 [1.0]      5 [1.4]      4 [1.5]      1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (40)         (42)                      
      Cyst                                            22           18           25           14           12                        
      Infiltration Cellular, Lymphocyte                                                       1 [3.0]                               
      Inflammation, Chronic                           23 [2.5]     19 [2.6]     17 [2.6]     14 [2.8]     16 [2.8]                  
   Ovary                                              (50)         (50)         (49)         (40)         (42)                      
      Amyloid Deposition                               1 [4.0]                                             1 [3.0]                  
      Angiectasis                                      1 [2.0]      1 [2.0]      4 [3.8]      3 [3.7]      4 [3.0]                  
      Cyst                                            38           35           37           28           29                        
      Hematocyst                                       1                                                                            
      Hemorrhage                                       2 [2.5]      2 [2.5]      7 [3.1]      5 [2.2]      4 [2.8]                  
      Thrombosis                                                                 2            1            1                        
      Bilateral, Cyst                                                                         1                                     
      Corpus Luteum, Hyperplasia                       1 [3.0]                   1 [3.0]      1 [3.0]      1 [2.0]                  
   Uterus                                             (50)         (50)         (49)         (40)         (42)                      
      Angiectasis                                      1 [4.0]                   4 [3.8]                   1 [2.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                            0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                    1 [2.0]      1 [2.0]                                            
      Infiltration Cellular, Histiocyte                                                                    1 [3.0]                  
      Inflammation, Chronic                            1 [3.0]      1 [2.0]                                1 [3.0]                  
      Thrombosis                                       2                         3                         1                        
      Endometrium, Hyperplasia, Cystic                22 [2.2]     27 [2.5]     29 [2.7]     24 [2.7]     22 [2.6]                  
   Vagina                                             (49)         (49)         (47)         (40)         (41)                      
      Cyst                                             2                         1                                                  
      Epithelium, Hyperplasia                          1 [3.0]      1 [2.0]      2 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (40)         (42)                      
      Hyperplasia                                     33 [3.0]     24 [3.1]     30 [2.9]     22 [2.6]     26 [2.8]                  
      Myelofibrosis                                                 1 [3.0]                                1 [3.0]                  
   Lymph Node                                         (14)         (23)         (16)         (12)         (16)                      
      Hematopoietic Cell Proliferation                 1 [3.0]      1 [4.0]      2 [2.5]                                            
      Hemorrhage                                                                 1 [3.0]                                            
      Hyperplasia, Lymphoid                            1 [4.0]      3 [4.0]                   1 [3.0]                               
      Hyperplasia, Plasma Cell                         2 [3.5]                                             1 [4.0]                  
      Pigmentation                                                                                         1 [2.0]                  
      Bronchial, Hemorrhage                                         1 [3.0]                                                         
      Iliac, Hematopoietic Cell Proliferation          1 [4.0]      1 [3.0]      1 [3.0]                                            
      Iliac, Hemorrhage                                                                                    1 [3.0]                  
      Iliac, Hyperplasia, Lymphoid                                  2 [4.0]      2 [3.5]                                            
      Inguinal, Hematopoietic Cell Proliferation                    1 [3.0]                                1 [2.0]                  
      Inguinal, Hyperplasia, Lymphoid                  2 [3.0]      4 [3.5]      2 [3.0]      1 [2.0]      2 [3.5]                  
      Inguinal, Hyperplasia, Plasma Cell               1 [3.0]                                                                      
      Inguinal, Pigmentation                                        1 [1.0]                                                         
      Lumbar, Hematopoietic Cell Proliferation         1 [3.0]                                                                      
      Lumbar, Hyperplasia, Lymphoid                                 1 [4.0]                                1 [3.0]                  
      Mediastinal, Hematopoietic Cell Proliferation    1 [3.0]                                                                      
      Mediastinal, Hemorrhage                          1 [4.0]      1 [2.0]      2 [3.5]                   1 [3.0]                  
      Mediastinal, Hyperplasia, Lymphoid               1 [3.0]      2 [2.0]                   1 [4.0]                               
      Mediastinal, Pigmentation                                     1 [2.0]                                                         
      Pancreatic, Hyperplasia, Lymphoid                                                       1 [3.0]                               
      Popliteal, Hyperplasia                                                     1 [4.0]                                            
      Popliteal, Hyperplasia, Lymphoid                                                        1 [3.0]                               
      Renal, Ectasia                                                1 [3.0]                                                         
      Renal, Hematopoietic Cell Proliferation                       1 [2.0]                                                         
      Renal, Hemorrhage                                             2 [2.5]      1 [2.0]                                            
      Renal, Hyperplasia, Lymphoid                                  3 [3.7]      2 [2.5]                                            
   Lymph Node, Mandibular                             (49)         (47)         (49)         (40)         (42)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                            0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Amyloid Deposition                               1 [3.0]                                                                      
      Atrophy                                          2 [2.5]      2 [3.0]      1 [2.0]                   4 [2.5]                  
      Ectasia                                          2 [4.0]      1 [4.0]                   3 [3.0]      2 [4.0]                  
      Hematopoietic Cell Proliferation                 7 [2.1]      3 [3.0]      2 [1.5]      4 [2.0]      6 [1.8]                  
      Hemorrhage                                       3 [3.3]      4 [1.8]      5 [2.6]      5 [2.0]      7 [2.1]                  
      Hyperplasia, Lymphoid                            9 [3.1]     10 [2.8]     17 [2.4]     10 [2.6]      4 [2.0]                  
      Hyperplasia, Plasma Cell                         5 [3.2]                                             3 [3.7]                  
      Infiltration Cellular, Plasma Cell               2 [3.0]                                                                      
      Pigmentation                                     5 [2.0]      4 [2.3]      2 [2.0]      4 [2.3]      6 [2.0]                  
   Lymph Node, Mesenteric                             (50)         (48)         (46)         (40)         (42)                      
      Atrophy                                          2 [3.0]      4 [2.8]      2 [2.5]      1 [3.0]      5 [2.4]                  
      Ectasia                                          2 [2.0]      3 [2.3]      2 [2.5]      3 [3.3]      1 [3.0]                  
      Hematopoietic Cell Proliferation                 6 [2.7]      6 [2.2]      2 [2.5]      3 [2.7]      8 [2.3]                  
      Hemorrhage                                      12 [2.5]     10 [2.1]      9 [2.8]      9 [2.3]     11 [2.3]                  
      Hyperplasia, Lymphoid                            6 [1.7]      7 [2.4]      9 [2.7]     10 [2.4]      7 [2.6]                  
      Pigmentation                                     2 [2.0]      7 [2.0]      3 [2.0]      2 [2.0]      4 [2.0]                  
   Spleen                                             (50)         (50)         (49)         (40)         (42)                      
      Amyloid Deposition                                                                      1 [3.0]                               
      Hematopoietic Cell Proliferation                31 [2.8]     21 [2.8]     32 [2.3]     26 [2.6]     29 [3.0]                  
      Pigmentation                                    13 [2.5]     24 [2.4]     12 [2.3]     10 [2.0]     12 [2.3]                  
      Lymphoid Follicle, Atrophy                       4 [3.3]      6 [2.5]      5 [2.8]      6 [2.7]      4 [2.8]                  
      Lymphoid Follicle, Hyperplasia                   7 [2.4]      3 [2.0]      7 [2.1]      6 [2.5]      7 [2.1]                  
   Thymus                                             (49)         (44)         (46)         (36)         (42)                      
      Atrophy                                          7 [2.6]      3 [2.0]      5 [2.8]      2 [2.5]      4 [2.8]                  
      Hemorrhage                                       1 [3.0]      4 [3.0]      2 [2.5]                   3 [3.0]                  
      Hyperplasia, Lymphoid                            7 [2.7]      3 [3.3]      3 [3.0]      7 [2.7]      2 [3.0]                  
      Thrombosis                                                                              1                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (40)         (42)                      
      Hyperplasia                                      9 [2.1]      9 [2.4]      8 [2.0]      6 [2.2]      7 [1.9]                  
   Skin                                               (50)         (50)         (49)         (40)         (42)                      
      Cyst Epithelial Inclusion                                                               1            2                        
      Edema                                            3 [3.0]      7 [3.0]      7 [2.9]      6 [2.7]      5 [3.2]                  
      Inflammation, Chronic                            1 [2.0]                   1 [2.0]      1 [2.0]      1 [4.0]                  
      Ulcer                                            8 [3.9]      5 [4.0]      1 [4.0]      5 [3.0]      3 [3.7]                  
      Epidermis, Hyperplasia                           7 [3.4]      5 [3.8]      3 [2.7]      4 [2.5]      3 [4.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                            0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
   Bone                                               (50)         (50)         (50)         (40)         (42)                      
      Fibrous Osteodystrophy                           2 [2.5]      7 [2.3]      9 [2.3]      6 [2.3]      4 [2.5]                  
      Hyperostosis                                                               1 [2.0]      1 [3.0]                               
      Myelofibrosis                                                                           1 [3.0]                               
      Cranium, Hyperostosis                                         1 [3.0]                                                         
      Femur, Callus                                                                                        1                        
      Femur, Hyperostosis                                                                     1 [4.0]                               
   Skeletal Muscle                                    (5)          (2)          (1)          (1)          (4)                       
      Inflammation, Chronic                            1 [3.0]                   1 [4.0]                                            
      Thrombosis                                                                                           1                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (40)         (42)                      
      Compression                                                   1 [4.0]                                                         
      Hemorrhage                                                    1 [3.0]      1 [1.0]                                            
      Necrosis                                                      1 [3.0]                                                         
   Peripheral Nerve                                   (7)          (5)          (3)          (5)          (6)                       
      Atrophy                                                       1 [2.0]      1 [2.0]      1 [2.0]                               
   Spinal Cord                                        (50)         (50)         (50)         (40)         (42)                      
      Cyst Epithelial Inclusion                                                  1            1            1                        
      Necrosis                                         1 [3.0]      1 [2.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (40)         (42)                      
      Amyloid Deposition                                                                                   1 [3.0]                  
      Edema                                            1 [2.0]      3 [3.3]      4 [2.8]      1 [3.0]      3 [2.7]                  
      Fibrosis, Focal                                                            1 [2.0]                                            
      Foreign Body                                     3                                                                            
      Hemorrhage                                       7 [1.6]      6 [2.7]      6 [1.5]      2 [2.0]      8 [2.1]                  
      Hyperplasia, Lymphoid                            1 [2.0]      1 [2.0]      3 [2.7]      4 [2.8]      1 [2.0]                  
      Infiltration Cellular, Histiocyte               12 [2.3]     11 [3.0]     21 [2.9]     12 [3.4]     10 [2.8]                  
      Infiltration Cellular, Mixed Cell                2 [2.5]                                1 [2.0]      1 [3.0]                  
      Inflammation, Chronic                            1 [2.0]                                2 [2.5]      2 [3.5]                  
      Alveolar Epithelium, Hyperplasia                 2 [1.5]      2 [2.0]     10 [2.0]      3 [2.7]      2 [2.0]                  
   Nose                                               (50)         (50)         (50)         (40)         (42)                      
      Foreign Body                                     2                                                                            
      Inflammation, Chronic                           11 [1.6]      2 [1.5]      7 [2.0]      2 [1.0]      4 [1.8]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                            0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (2)          (1)          (2)                       
      Atrophy                                                                    1 [4.0]      1 [3.0]                               
      Cataract                                                                                             1 [3.0]                  
      Inflammation, Chronic                                                      1 [3.0]                                            
   Harderian Gland                                    (49)         (49)         (50)         (40)         (41)                      
      Atrophy                                                                    1 [3.0]                   1 [3.0]                  
      Hyperplasia, Focal                                                         1 [2.0]      2 [2.5]      1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (40)         (42)                      
      Amyloid Deposition                               2 [3.5]                   1 [3.0]                   2 [3.0]                  
      Cyst                                             2            7            5            7            5                        
      Hydronephrosis                                   2 [1.5]      7 [2.6]      5 [2.6]      5 [2.8]      3 [2.3]                  
      Infarct                                                       1 [2.0]      3 [3.3]      2 [3.0]                               
      Infiltration Cellular, Mixed Cell               10 [2.1]     20 [2.4]     15 [2.3]     14 [2.5]     15 [2.1]                  
      Inflammation, Chronic                            3 [3.0]                                                                      
      Metaplasia, Osseous                              1 [1.0]                                             2 [2.0]                  
      Nephropathy                                     29 [2.0]     31 [2.6]     41 [2.2]     26 [2.2]     33 [2.2]                  
      Renal Tubule, Accumulation, Hyaline Droplet      1 [4.0]      2 [3.5]      2 [3.0]      3 [3.3]      3 [2.7]                  
      Renal Tubule, Dilatation                         1 [3.0]      3 [3.0]                   1 [2.0]                               
      Renal Tubule, Necrosis                                                     1 [2.0]      1 [2.0]                               
      Renal Tubule, Pigmentation                       1 [3.0]      1 [3.0]      1 [2.0]      2 [2.5]      2 [3.0]                  
   Urinary Bladder                                    (50)         (50)         (49)         (40)         (42)                      
      Hyperplasia, Lymphoid                            1 [2.0]      1 [2.0]      3 [2.3]      2 [2.5]      3 [2.3]                  
      Inflammation, Chronic                            1 [2.0]      1 [4.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                              0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           37           32                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           20           25           23           12                        
    Natural Death                                      7            9           11            5           10                        
    Accidently Killed                                                            1            1            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           20           13            7            7                        
    Moribund Sacrifice                                              1                                                               
    Natural Death                                                                                          1                        
  Other                                                                                       1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           37           32                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (50)         (49)         (37)         (32)                      
      Edema                                                                      2 [2.0]      1 [2.0]                               
   Intestine Large, Cecum                             (49)         (49)         (48)         (35)         (30)                      
      Edema                                           13 [2.0]     11 [2.2]      8 [2.3]     14 [2.1]      2 [2.0]                  
      Infiltration Cellular, Lymphocyte                1 [4.0]                                                                      
   Intestine Small, Duodenum                          (49)         (50)         (49)         (36)         (32)                      
      Amyloid Deposition                               1 [2.0]                                                                      
      Epithelium, Hyperplasia                          3 [2.3]      4 [2.0]      4 [2.5]      1 [2.0]      1 [2.0]                  
   Intestine Small, Jejunum                           (49)         (50)         (46)         (36)         (29)                      
      Amyloid Deposition                               1 [2.0]                                                                      
      Epithelium, Hyperplasia                          4 [2.3]      2 [2.5]                   1 [3.0]      1 [2.0]                  
   Intestine Small, Ileum                             (49)         (48)         (47)         (35)         (30)                      
      Amyloid Deposition                               1 [3.0]                                                                      
   Liver                                              (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                                                                                   1 [2.0]                  
      Angiectasis                                      1 [2.0]      1 [2.0]                                1 [2.0]                  
      Basophilic Focus                                 2            4            2            2                                     
      Cholangiofibrosis                                                          1 [4.0]                                            
      Clear Cell Focus                                 1            1                                                               
      Cyst                                                                       2            1                                     
      Eosinophilic Focus                               3            2            2            1            2                        
      Hematopoietic Cell Proliferation                 9 [1.9]      7 [2.6]     12 [2.7]      6 [3.2]      5 [2.4]                  
      Hemorrhage                                                    1 [4.0]      1 [3.0]                   1 [3.0]                  
      Hyperplasia, Lymphoid                                                      1 [2.0]                                            
      Infarct                                                                                              1 [2.0]                  
      Infiltration Cellular, Mixed Cell               10 [2.0]      7 [2.1]      2 [2.0]      5 [2.6]      2 [2.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                              0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis, Focal                                  8 [2.5]      9 [2.7]      7 [3.0]      4 [2.5]      3 [2.0]                  
      Regeneration                                                               1                         1                        
      Tension Lipidosis                                                          1                         1                        
      Centrilobular, Necrosis                          2 [2.0]                   1 [2.0]                                            
      Hepatocyte, Hypertrophy                         15 [2.1]     15 [2.5]      9 [2.3]      6 [2.5]     15 [2.3]                  
      Hepatocyte, Vacuolization Cytoplasmic            1 [2.0]      1 [2.0]      2 [3.0]                   1 [2.0]                  
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                                                                        1 [3.0]                  
      Kupffer Cell, Hyperplasia                        2 [3.0]                                1 [3.0]      1 [3.0]                  
      Kupffer Cell, Pigmentation                       2 [2.0]      3 [2.7]                   2 [2.0]      3 [2.3]                  
   Mesentery                                          (1)          (2)                       (3)          (1)                       
      Hemorrhage                                                    1 [4.0]                                1 [3.0]                  
      Fat, Necrosis                                                 1 [2.0]                   3 [2.7]                               
   Pancreas                                           (50)         (50)         (50)         (37)         (31)                      
      Atrophy                                                                    1 [4.0]                                            
      Cyst                                                                                                 1                        
      Edema                                            1 [3.0]                   2 [2.0]      2 [3.0]                               
      Infiltration Cellular, Mixed Cell                                                                    1 [2.0]                  
      Acinus, Cytoplasmic Alteration                   1 [3.0]      2 [3.5]      1 [3.0]      1 [4.0]      1 [3.0]                  
   Salivary Glands                                    (50)         (50)         (50)         (37)         (32)                      
      Atrophy                                          1 [3.0]                                1 [2.0]                               
      Hyperplasia, Lymphoid                                                                                1 [2.0]                  
      Infiltration Cellular, Lymphoid                  1 [2.0]                                             5 [1.8]                  
      Infiltration Cellular, Mixed Cell                1 [2.0]                   1 [2.0]      2 [1.5]                               
   Stomach, Forestomach                               (49)         (50)         (50)         (37)         (32)                      
      Diverticulum                                                                            1                                     
      Edema                                            1 [2.0]                   2 [2.0]      1 [2.0]                               
      Ulcer                                            1 [2.0]                                                                      
      Epithelium, Hyperplasia                          2 [1.0]                   1 [3.0]      1 [2.0]      1 [1.0]                  
   Stomach, Glandular                                 (49)         (50)         (50)         (37)         (32)                      
      Edema                                                         1 [2.0]      2 [2.0]      2 [2.0]                               
      Erosion                                          2 [2.5]      2 [2.0]      1 [3.0]                   1 [2.0]                  
      Glands, Hyperplasia, Cystic                      9 [2.2]     13 [2.1]     10 [2.5]     15 [2.5]      6 [2.3]                  
   Tooth                                                           (1)                                                              
      Malformation                                                  1                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)          (1)                                                 
      Inflammation, Chronic                            1 [4.0]                                                                      
   Heart                                              (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                               1 [2.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                              0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Cardiomyopathy                                  12 [1.9]      7 [2.0]     19 [1.6]     13 [1.7]      7 [1.7]                  
      Inflammation                                     1 [2.0]                                                                      
      Inflammation, Chronic                            1 [1.0]      5 [2.6]      3 [2.3]      2 [2.5]      1 [1.0]                  
      Mineralization                                                2 [2.5]      1 [1.0]      1 [2.0]                               
      Thrombosis                                       2            4            5            3            3                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (37)         (32)                      
      Accessory Adrenal Cortical Nodule                8 [3.0]      9 [3.0]      7 [3.0]      6 [3.0]      6 [3.0]                  
      Amyloid Deposition                               1 [2.0]                                                                      
      Hyperplasia, Focal                               2 [2.5]      5 [2.0]      3 [2.0]      2 [2.0]                               
      Hypertrophy, Focal                               6 [2.5]      5 [3.0]      4 [2.3]      4 [2.3]      4 [2.0]                  
      Capsule, Hyperplasia                             2 [2.5]      2 [3.0]      1 [3.0]      3 [2.3]      2 [2.0]                  
   Adrenal Medulla                                    (50)         (50)         (49)         (37)         (32)                      
      Hyperplasia                                      2 [2.0]                   1 [1.0]                   1 [3.0]                  
   Islets, Pancreatic                                 (50)         (50)         (50)         (36)         (31)                      
      Hyperplasia                                     15 [1.9]     13 [2.1]     12 [2.2]      6 [2.0]      6 [2.0]                  
   Pituitary Gland                                    (48)         (49)         (49)         (36)         (31)                      
      Pars Distalis, Cyst                              1            2            3            2            1                        
   Thyroid Gland                                      (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                               1 [2.0]                                                                      
      Degeneration, Cystic                            29 [2.3]     23 [2.0]     33 [2.3]     15 [2.1]     15 [2.2]                  
      Follicular Cell, Hyperplasia                     3 [1.0]                   2 [1.5]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (2)          (2)          (1)          (1)                       
      Bilateral, Dilatation                                         1 [4.0]                                                         
   Epididymis                                         (50)         (50)         (50)         (37)         (32)                      
      Atypia Cellular                                  1 [3.0]      3 [2.3]      3 [2.3]      3 [2.0]      3 [2.3]                  
      Granuloma Sperm                                               1 [3.0]                                                         
      Inflammation, Chronic                            1 [2.0]                   1 [3.0]                                            
      Spermatocele                                                               2 [2.5]                   1 [3.0]                  
   Penis                                                           (2)          (1)          (3)          (1)                       
      Inflammation, Chronic Active                                  2 [2.5]      1 [2.0]      1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                              0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Preputial Gland                                    (50)         (50)         (50)         (37)         (32)                      
      Cyst                                             6            7            6            6            2                        
      Inflammation, Chronic                           11 [2.6]     11 [2.6]     18 [3.1]      8 [2.6]      9 [2.6]                  
   Prostate                                           (50)         (50)         (50)         (37)         (32)                      
      Inflammation, Chronic                            8 [2.6]      3 [2.7]     12 [2.1]      6 [2.8]      5 [2.8]                  
   Seminal Vesicle                                    (50)         (50)         (50)         (37)         (32)                      
      Degeneration                                                  1 [3.0]                   1 [3.0]      1 [3.0]                  
      Dilatation                                       2 [3.0]                                             3 [3.0]                  
      Inflammation, Chronic                            2 [3.0]      3 [2.7]                   3 [3.0]                               
   Testes                                             (50)         (50)         (50)         (37)         (32)                      
      Germinal Epithelium, Atrophy                     4 [2.0]      7 [2.1]      5 [2.4]      3 [1.7]      4 [2.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (37)         (32)                      
      Hyperplasia                                     43 [3.2]     29 [3.1]     35 [3.1]     27 [3.0]     24 [2.9]                  
      Infiltration Cellular, Mast Cell                 1 [3.0]                                                                      
      Myelofibrosis                                                                                        1 [3.0]                  
   Lymph Node                                         (12)         (10)         (15)         (6)          (2)                       
      Hematopoietic Cell Proliferation                 3 [2.7]      2 [2.5]      1 [3.0]                                            
      Hyperplasia, Lymphoid                            1 [2.0]      3 [3.7]      2 [3.0]      2 [4.0]                               
      Hyperplasia, Plasma Cell                         3 [3.3]                                             2 [3.5]                  
      Bronchial, Hyperplasia, Lymphoid                              1 [3.0]                                                         
      Iliac, Hyperplasia, Lymphoid                                               1 [4.0]      1 [4.0]                               
      Iliac, Pigmentation                                                        1 [3.0]                                            
      Inguinal, Hematopoietic Cell Proliferation       1 [2.0]                   1 [3.0]      1 [3.0]                               
      Inguinal, Hyperplasia, Lymphoid                  2 [2.0]      1 [3.0]      6 [3.5]      1 [3.0]                               
      Inguinal, Hyperplasia, Plasma Cell               2 [3.0]                                                                      
      Inguinal, Pigmentation                                                     1 [2.0]                                            
      Lumbar, Pigmentation                                                       1 [2.0]                                            
      Mediastinal, Hemorrhage                          1 [2.0]                                                                      
      Mediastinal, Hyperplasia, Lymphoid                                         3 [3.3]                                            
      Renal, Hyperplasia, Lymphoid                     1 [3.0]                                1 [4.0]                               
      Renal, Hyperplasia, Plasma Cell                  1 [3.0]                                                                      
   Lymph Node, Mandibular                             (50)         (50)         (49)         (37)         (32)                      
      Atrophy                                                                    1 [2.0]      3 [2.7]                               
      Ectasia                                          2 [3.5]                   1 [3.0]      1 [4.0]      2 [3.5]                  
      Hematopoietic Cell Proliferation                 7 [2.1]                   6 [2.5]      4 [2.5]      5 [2.2]                  
      Hemorrhage                                                                 3 [1.7]                                            
      Hyperplasia, Lymphoid                           11 [2.2]      7 [3.0]      9 [2.7]      6 [2.5]      9 [2.8]                  
      Hyperplasia, Plasma Cell                        11 [2.9]      9 [3.0]      6 [2.8]      3 [2.3]      4 [2.5]                  
      Pigmentation                                                  1 [2.0]      1 [2.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                              0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (36)         (32)                      
      Atrophy                                          1 [2.0]                   2 [3.0]      3 [2.7]                               
      Ectasia                                          2 [3.0]      7 [2.9]      3 [2.3]      6 [2.7]      2 [2.5]                  
      Hematopoietic Cell Proliferation                12 [2.4]      3 [2.7]      8 [2.6]      3 [2.3]      4 [2.3]                  
      Hemorrhage                                       7 [2.3]     14 [1.9]     17 [2.5]      8 [2.4]      9 [2.1]                  
      Hyperplasia, Lymphoid                           15 [2.2]     16 [2.6]      9 [2.2]     10 [2.6]      6 [2.5]                  
      Infiltration Cellular, Histiocyte                1 [2.0]                                                                      
      Necrosis                                         1 [3.0]      1 [2.0]      3 [2.7]                                            
      Pigmentation                                     1 [2.0]      1 [2.0]      1 [2.0]                   1 [2.0]                  
   Spleen                                             (49)         (50)         (50)         (37)         (32)                      
      Hematopoietic Cell Proliferation                31 [3.4]     29 [3.0]     27 [3.0]     18 [3.1]     20 [2.7]                  
      Pigmentation                                     2 [2.0]      3 [2.0]      4 [2.0]      2 [2.5]                               
      Lymphoid Follicle, Atrophy                       4 [3.3]      5 [2.6]      5 [2.6]      7 [2.9]      2 [3.0]                  
      Lymphoid Follicle, Hyperplasia                                6 [2.0]      5 [2.4]      2 [2.5]      1 [2.0]                  
   Thymus                                             (48)         (45)         (47)         (33)         (32)                      
      Atrophy                                         15 [2.6]     12 [2.9]     15 [2.7]     13 [2.8]      7 [2.6]                  
      Cyst                                             2            1            2            1            1                        
      Hyperplasia, Lymphoid                            1 [2.0]      1 [2.0]      6 [2.7]      1 [4.0]      6 [2.2]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (37)         (32)                      
      Cyst Epithelial Inclusion                                     2                         1                                     
      Edema                                           10 [2.9]      2 [3.0]      7 [2.4]      7 [3.0]      1 [2.0]                  
      Ulcer                                           14 [3.9]     14 [3.6]     13 [3.8]      7 [4.0]      6 [4.0]                  
      Epidermis, Hyperplasia                          13 [3.5]     12 [3.1]     12 [3.4]      8 [3.3]      5 [3.6]                  
      Epidermis, Inflammation                          1 [3.0]                   1 [4.0]                                            
      Epidermis, Ulcer                                                           1 [4.0]                                            
      Subcutaneous Tissue, Edema                                    1 [4.0]      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (37)         (32)                      
      Fibrous Osteodystrophy                                                     1 [2.0]      1 [2.0]      1 [2.0]                  
      Fracture                                                                                             1                        
      Femur, Osteopetrosis                                          1 [3.0]                                2 [3.0]                  
      Scapula, Osteopetrosis                                                                               1 [3.0]                  
   Skeletal Muscle                                    (1)          (2)          (1)          (3)          (2)                       
      Hemorrhage                                       1 [3.0]                                                                      
      Pigmentation                                                                            1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                              0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (37)         (32)                      
      Hydrocephalus                                                 1 [4.0]                                                         
      Necrosis                                                                                             1 [2.0]                  
   Spinal Cord                                        (50)         (50)         (50)         (37)         (32)                      
      Cyst Epithelial Inclusion                        1                                                   1                        
      Demyelination                                                                                        1 [3.0]                  
      Infiltration Cellular, Mast Cell                 1 [3.0]                                                                      
      Necrosis                                         1 [2.0]      1 [1.0]                                1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (37)         (32)                      
      Congestion                                                                              1 [3.0]                               
      Edema                                                         1 [3.0]      2 [3.0]      4 [2.5]                               
      Fibrosis, Focal                                                            1 [3.0]                                            
      Foreign Body                                     1                         1            1            1                        
      Hemorrhage                                       5 [1.6]      3 [2.0]      7 [2.4]      5 [1.6]      2 [2.5]                  
      Hyperplasia, Lymphoid                            1 [3.0]                                1 [1.0]      1 [3.0]                  
      Infiltration Cellular, Histiocyte               12 [2.3]     16 [2.9]     13 [2.8]     16 [3.2]     14 [3.0]                  
      Inflammation, Chronic                            2 [2.5]      1 [3.0]      5 [3.0]      2 [2.5]      1 [3.0]                  
      Thrombosis                                       1            1                                                               
      Alveolar Epithelium, Hyperplasia                 6 [1.5]      3 [2.3]                   1 [1.0]      4 [2.8]                  
   Nose                                               (50)         (50)         (50)         (36)         (32)                      
      Foreign Body                                     1            1            1                                                  
      Inflammation, Chronic                            5 [2.2]      5 [2.0]      5 [1.8]      3 [1.7]      4 [1.8]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (50)         (49)         (37)         (32)                      
      Hyperplasia, Focal                               2 [2.5]                   1 [2.0]      1 [3.0]      1 [2.0]                  
      Hypertrophy, Focal                                            1 [1.0]                                                         
      Inflammation                                     1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                               3 [2.7]                                                                      
      Cyst                                            27           23           26           24           17                        
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: PERINATAL EXPOS                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/09/04    
Route: IN-UTERO                                    AZT TRANSPLACENTAL CARCINOGENESIS STUDY                        Time: 14:01:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                              0            50           100          200          300                       
                                                      MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                  30 [2.1]     20 [3.0]     17 [2.8]     16 [2.9]     14 [2.3]                  
      Infarct                                          1 [2.0]                                1 [4.0]      1 [2.0]                  
      Infiltration Cellular, Mixed Cell                9 [2.0]     11 [2.1]     17 [2.4]      9 [2.7]     12 [2.3]                  
      Inflammation, Chronic                            1 [2.0]      2 [2.0]      1 [3.0]      2 [2.0]                               
      Inflammation, Suppurative                        4 [3.5]                                                                      
      Metaplasia, Osseous                              1 [2.0]      1 [2.0]      1 [1.0]                                            
      Mineralization                                                1 [3.0]                   1 [3.0]                               
      Nephropathy                                     40 [1.8]     40 [1.8]     42 [1.9]     30 [2.1]     23 [2.0]                  
      Renal Tubule, Dilatation                                      1 [2.0]      5 [2.4]      2 [2.5]      1 [2.0]                  
      Renal Tubule, Necrosis                           3 [1.3]                                1 [4.0]                               
      Renal Tubule, Pigmentation                                    1 [2.0]      2 [3.0]      2 [2.0]                               
   Ureter                                                          (3)          (1)          (1)                                    
      Dilatation                                                    2 [2.5]      1 [2.0]      1 [1.0]                               
   Urethra                                            (1)          (4)          (5)          (3)          (3)                       
      Angiectasis                                      1 [4.0]                   3 [4.0]      1 [4.0]      1 [4.0]                  
      Inflammation, Chronic                            1 [3.0]      1 [3.0]      3 [3.0]      1 [3.0]                               
      Bulbourethral Gland, Cyst                                     1            2            1            2                        
   Urinary Bladder                                    (50)         (50)         (50)         (37)         (32)                      
      Edema                                                                      1 [3.0]                   2 [3.0]                  
      Hemorrhage                                                                 3 [2.3]      2 [3.5]      2 [2.0]                  
      Inflammation, Chronic                            4 [2.5]                   2 [2.5]      1 [2.0]      1 [3.0]                  
      Transitional Epithelium, Hyperplasia             4 [2.5]      1 [2.0]      3 [2.0]      1 [2.0]      1 [2.0]                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   15                                                              
                                                                                                                                   
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