National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19843

TDMS Study 88138-03 Pathology Tables

NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03
Route: DOSED FEED                                                                                                 Time: 15:17:01

                                                         FINAL #1 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  04/26/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           10            9           13                                     
    Natural Death                                      2            2            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           38           37           34                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)                                                          
      Periesophageal Tissue, Necrosis, Fatty                        1 (2%)                                                          
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 (2%)                                                                       
      Metaplasia, Mucous                               1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)       3 (6%)       2 (4%)       3 (6%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                8 (16%)      8 (16%)     14 (28%)      6 (12%)                               
      Ulcer                                                         1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)                                                          
      Mineralization                                                             1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                             1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)       2 (4%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       2 (4%)       5 (10%)      1 (2%)                                
      Basophilic Focus                                48 (96%)     48 (96%)     41 (82%)     43 (86%)                               
      Clear Cell Focus                                15 (30%)     13 (26%)     10 (20%)     10 (20%)                               
      Degeneration, Cystic                             1 (2%)                    3 (6%)       4 (8%)                                
      Eosinophilic Focus                                            6 (12%)      6 (12%)      9 (18%)                               
      Fatty Change, Diffuse                           11 (22%)      8 (16%)      9 (18%)     20 (40%)                               
      Fibrosis                                                                                1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       6 (12%)      4 (8%)       2 (4%)                                
      Hepatodiaphragmatic Nodule                       5 (10%)      6 (12%)      6 (12%)      6 (12%)                               
      Inflammation, Chronic Active                    46 (92%)     38 (76%)     29 (58%)     30 (60%)                               
      Mixed Cell Focus                                10 (20%)     11 (22%)      5 (10%)      5 (10%)                               
      Necrosis                                        12 (24%)      6 (12%)     11 (22%)     12 (24%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Cyst                                                                         1 (2%)                                
      Bile Duct, Hyperplasia                          10 (20%)     35 (70%)     39 (78%)     40 (80%)                               
      Hepatocyte, Centrilobular, Hypertrophy                       27 (54%)     30 (60%)     33 (66%)                               
      Oval Cell, Hyperplasia                                                                  3 (6%)                                
   Mesentery                                          (12)         (18)         (10)         (6)                                    
      Fat, Necrosis                                   11 (92%)     18 (100%)    10 (100%)     4 (67%)                               
   Oral Mucosa                                        (4)          (8)          (4)          (4)                                    
      Hyperplasia, Squamous                                                                   1 (25%)                               
      Gingival, Inflammation                           4 (100%)     7 (88%)      4 (100%)     4 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                                           1 (2%)       1 (2%)                                
      Inflammation                                    12 (24%)      3 (6%)       2 (4%)       6 (12%)                               
      Acinus, Atrophy                                 17 (34%)     10 (20%)     11 (22%)     12 (24%)                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)                    1 (2%)       1 (2%)                                
      Basophilic Focus                                 1 (2%)                    1 (2%)                                             
      Inflammation                                                               1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            2 (4%)       2 (4%)       2 (4%)       4 (8%)                                
      Inflammation                                     4 (8%)       2 (4%)       2 (4%)       3 (6%)                                
      Ulcer                                                         1 (2%)       1 (2%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                                       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation                                                               2 (4%)       3 (6%)                                
      Mineralization                                                2 (4%)       2 (4%)                                             
      Ulcer                                            1 (2%)                                 1 (2%)                                
      Epithelium, Atrophy                                                        1 (2%)                                             
   Tooth                                                                        (3)          (3)                                    
      Inflammation                                                               3 (100%)     2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Mineralization                                                                          1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  46 (92%)     46 (92%)     48 (96%)     46 (92%)                               
      Atrium, Thrombosis                                            1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Angiectasis                                     42 (84%)     36 (72%)     18 (36%)     24 (48%)                               
      Atrophy                                          1 (2%)                                 1 (2%)                                
      Degeneration, Cystic                             3 (6%)       2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia                                      6 (12%)     10 (20%)      6 (12%)      6 (12%)                               
      Hypertrophy                                      7 (14%)      5 (10%)      5 (10%)      8 (16%)                               
      Karyomegaly                                      1 (2%)                                                                       
      Necrosis                                         5 (10%)      7 (14%)      5 (10%)      2 (4%)                                
      Vacuolization Cytoplasmic                       14 (28%)     16 (32%)     15 (30%)     20 (40%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)       2 (4%)                                             
      Necrosis                                         2 (4%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Parathyroid Gland                                  (47)         (48)         (44)         (48)                                   
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                     30 (60%)     30 (60%)     23 (46%)     23 (46%)                               
      Cyst                                             2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Hyperplasia                                     23 (46%)     24 (48%)     20 (40%)     18 (36%)                               
      Inflammation                                     1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             34 (68%)     11 (22%)     13 (26%)      8 (16%)                               
      Follicle, Cyst                                   1 (2%)                    1 (2%)       1 (2%)                                
      Follicle, Hyperplasia                                         2 (4%)                                                          
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Cyst                                             3 (6%)       2 (4%)       1 (2%)                                             
      Hyperplasia                                      6 (12%)      1 (2%)       2 (4%)                                             
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation                                     2 (4%)       2 (4%)       2 (4%)                                             
      Metaplasia, Squamous                             1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             6 (12%)     13 (26%)     10 (20%)      9 (18%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                                      1 (2%)                                
      Inflammation                                                                            1 (2%)                                
      Cervix, Hypertrophy                                                                     1 (2%)                                
      Endometrium, Hyperplasia, Cystic                12 (24%)     20 (40%)     20 (40%)     20 (40%)                               
      Endometrium, Hyperplasia, Adenomatous            1 (2%)       1 (2%)                    1 (2%)                                
      Serosa, Inflammation, Granulomatous                           2 (4%)                                                          
   Vagina                                                          (1)          (1)                                                 
      Inflammation                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Myelofibrosis                                    2 (4%)                    2 (4%)       6 (12%)                               
      Necrosis                                                                   1 (2%)       1 (2%)                                
      Erythroid Cell, Hyperplasia                      8 (16%)      6 (12%)      7 (14%)      2 (4%)                                
      Myeloid Cell, Hyperplasia                       11 (22%)     13 (26%)     20 (40%)     13 (26%)                               
   Lymph Node                                         (8)          (8)          (11)         (12)                                   
      Axillary, Right, Ectasia                                                   1 (9%)                                             
      Axillary, Right, Infiltration Cellular,                                                                                       
        Plasma Cell                                                              1 (9%)                                             
      Deep Cervical, Ectasia                           1 (13%)                                                                      
      Deep Cervical, Hemorrhage                        1 (13%)                                                                      
      Deep Cervical, Infiltration Cellular, Plasma                                                                                  
        Cell                                           3 (38%)                                2 (17%)                               
      Deep Cervical, Infiltration Cellular,                                                                                         
        Histiocyte                                     3 (38%)                                                                      
      Mediastinal, Hemorrhage                                                                 2 (17%)                               
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                           2 (25%)      1 (13%)      4 (36%)      2 (17%)                               
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                                               1 (9%)       1 (8%)                                
      Pancreatic, Hemorrhage                                        2 (25%)                                                         
      Pancreatic, Infiltration Cellular, Histiocyte                 3 (38%)                   1 (8%)                                
      Pancreatic, Pigmentation, Hemosiderin                         2 (25%)                                                         
      Renal, Infiltration Cellular, Histiocyte                      1 (13%)                   1 (8%)                                
      Renal, Pigmentation                                                                     1 (8%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Plasma Cell                            1 (2%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Histiocyte               50 (100%)    49 (98%)     48 (96%)     49 (98%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Accessory Spleen                                                           1 (2%)       1 (2%)                                
      Autolysis                                                                  2 (4%)                                             
      Fibrosis                                         1 (2%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                47 (96%)     45 (90%)     40 (80%)     45 (90%)                               
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)       2 (4%)                                
      Infarct                                          1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)       1 (2%)                                                          
      Pigmentation, Hemosiderin                       48 (98%)     50 (100%)    49 (98%)     49 (98%)                               
      Lymphoid Follicle, Atrophy                                    5 (10%)                                                         
      Red Pulp, Hyperplasia                                                                   1 (2%)                                
   Thymus                                             (50)         (49)         (46)         (50)                                   
      Atrophy                                         49 (98%)     48 (98%)     44 (96%)     49 (98%)                               
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Galactocele                                      7 (14%)      3 (6%)       2 (4%)       2 (4%)                                
      Hyperplasia                                      3 (6%)       4 (8%)       1 (2%)       3 (6%)                                
      Inflammation                                     1 (2%)       1 (2%)       1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                  1 (2%)       1 (2%)                                
      Sebaceous Gland, Hyperplasia                                                            1 (2%)                                
      Subcutaneous Tissue, Necrosis                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                                                  2 (4%)                                
   Skeletal Muscle                                    (1)          (1)          (3)          (1)                                    
      Inflammation                                     1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                                    1 (2%)                                             
      Hemorrhage                                       2 (4%)       1 (2%)       2 (4%)                                             
      Hydrocephalus                                    1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Inflammation                                     1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                      1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                                           2 (4%)       1 (2%)                                             
      Inflammation, Granulomatous                     12 (24%)      5 (10%)      9 (18%)      7 (14%)                               
      Metaplasia, Squamous                                                       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                18 (36%)     18 (36%)     13 (26%)     15 (30%)                               
      Alveolus, Infiltration Cellular, Histiocyte     50 (100%)    50 (100%)    50 (100%)    50 (100%)                              
      Interstitium, Fibrosis                                                     1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation                                     2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Thrombosis                                                                 2 (4%)                                             
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Inflammation                                                  4 (8%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Lens, Cataract                                   1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Optic Nerve, Fibrosis                                                                   1 (2%)                                
      Retina, Degeneration                             2 (4%)       2 (4%)       4 (8%)       4 (8%)                                
      Retina, Dysplasia                                             1 (2%)                                                          
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 14 (28%)     10 (20%)      6 (12%)      9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                              2 (4%)       1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Infarct                                                       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Nephropathy                                     47 (94%)     49 (98%)     48 (96%)     49 (98%)                               
      Cortex, Inflammation                                                                    1 (2%)                                
      Cortex, Mineralization                           2 (4%)       1 (2%)       4 (8%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Medulla, Fibrosis                                1 (2%)                                                                       
      Medulla, Mineralization                         43 (86%)     49 (98%)     49 (98%)     46 (92%)                               
      Pelvis, Inflammation                             1 (2%)                    4 (8%)       2 (4%)                                
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)       2 (4%)       2 (4%)       4 (8%)                                
      Renal Tubule, Cyst                                                                      1 (2%)                                
      Renal Tubule, Hyperplasia                                     1 (2%)       1 (2%)       1 (2%)                                
      Renal Tubule, Pigmentation                                                              1 (2%)                                
      Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation                                     1 (2%)       1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           12           16           44                                     
    Natural Death                                      3           11            3            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           27           31            2                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Erosion                                                                    1 (2%)                                             
      Inflammation                                                               1 (2%)                                             
      Parasite Metazoan                                1 (2%)       1 (2%)       1 (2%)                                             
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                6 (12%)      6 (12%)      8 (16%)      5 (10%)                               
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Erosion                                          1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation                                                                            4 (8%)                                
      Mineralization                                                                          2 (4%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                24 (48%)     25 (50%)     32 (64%)     19 (38%)                               
      Clear Cell Focus                                19 (38%)     19 (38%)     18 (36%)                                            
      Congestion                                       1 (2%)                                                                       
      Degeneration, Cystic                             8 (16%)     11 (22%)     20 (40%)     15 (30%)                               
      Eosinophilic Focus                               5 (10%)     14 (28%)     10 (20%)      9 (18%)                               
      Fatty Change, Diffuse                           22 (44%)     20 (40%)     22 (44%)     15 (30%)                               
      Hematopoietic Cell Proliferation                 4 (8%)       1 (2%)       2 (4%)       4 (8%)                                
      Hepatodiaphragmatic Nodule                       2 (4%)       6 (12%)      1 (2%)       1 (2%)                                
      Infarct                                                                                 1 (2%)                                
      Inflammation, Chronic Active                    22 (44%)     21 (42%)     35 (70%)     33 (66%)                               
      Inflammation, Granulomatous                      1 (2%)                                 2 (4%)                                
      Mineralization                                                                          1 (2%)                                
      Mixed Cell Focus                                 9 (18%)     17 (34%)     22 (44%)      4 (8%)                                
      Necrosis                                        19 (38%)     19 (38%)      9 (18%)     14 (28%)                               
      Bile Duct, Cyst                                               1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          49 (98%)     46 (92%)     48 (96%)     50 (100%)                              
      Hepatocyte, Multinucleated                       1 (2%)                    1 (2%)                                             
      Hepatocyte, Centrilobular, Hypertrophy                       17 (34%)     31 (62%)     19 (38%)                               
      Hepatocyte, Centrilobular, Necrosis                                                     1 (2%)                                
      Vein, Inflammation                                                                      1 (2%)                                
   Mesentery                                          (9)          (12)         (8)          (4)                                    
      Inflammation                                     1 (11%)                   1 (13%)      1 (25%)                               
      Fat, Necrosis                                    7 (78%)      7 (58%)      7 (88%)      3 (75%)                               
   Oral Mucosa                                        (8)          (8)          (5)          (7)                                    
      Gingival, Hyperplasia                                                      1 (20%)                                            
      Gingival, Inflammation                           8 (100%)     6 (75%)      5 (100%)     5 (71%)                               
      Pharyngeal, Inflammation                                                                1 (14%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                              1 (2%)                                                          
      Cyst                                                                                    3 (6%)                                
      Inflammation                                    14 (28%)     16 (32%)      6 (12%)      9 (18%)                               
      Metaplasia, Hepatocyte                                                                  1 (2%)                                
      Acinus, Atrophy                                 20 (40%)     21 (42%)     22 (44%)     10 (20%)                               
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Salivary Glands                                    (49)         (50)         (50)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)       3 (6%)                                             
      Inflammation                                                  2 (4%)                                                          
   Stomach, Forestomach                               (50)         (49)         (49)         (50)                                   
      Autolysis                                                     1 (2%)                                                          
      Hyperplasia, Squamous                            7 (14%)      4 (8%)      10 (20%)     17 (34%)                               
      Inflammation                                     8 (16%)      6 (12%)      8 (16%)     12 (24%)                               
      Mineralization                                                1 (2%)       1 (2%)       3 (6%)                                
      Ulcer                                            4 (8%)       1 (2%)       8 (16%)      8 (16%)                               
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Erosion                                          5 (10%)      2 (4%)       3 (6%)       3 (6%)                                
      Hyperplasia                                                                1 (2%)                                             
      Inflammation                                     5 (10%)      5 (10%)      4 (8%)       7 (14%)                               
      Mineralization                                                             5 (10%)     15 (30%)                               
      Ulcer                                            1 (2%)                    1 (2%)       4 (8%)                                
   Tooth                                              (3)          (5)          (2)          (3)                                    
      Inflammation                                     1 (33%)                   1 (50%)      1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Inflammation                                                               1 (2%)                                             
      Mineralization                                                1 (2%)       1 (2%)      11 (22%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Pulmonary Artery, Pulmonary Vein, Hypertrophy                              1 (2%)                                             
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  48 (96%)     48 (96%)     47 (94%)     49 (98%)                               
      Mineralization                                                             2 (4%)       6 (12%)                               
      Aorta, Tunic, Media, Mineralization                           1 (2%)                                                          
      Atrium, Thrombosis                               3 (6%)       5 (10%)      2 (4%)       1 (2%)                                
      Endocardium, Hyperplasia                                      2 (4%)                                                          
      Valve, Thrombosis                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Angiectasis                                      4 (8%)       4 (8%)       2 (4%)       1 (2%)                                
      Atrophy                                                       1 (2%)                                                          
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 5 (10%)                   2 (4%)                                             
      Hyperplasia                                      1 (2%)       4 (8%)      11 (22%)      4 (8%)                                
      Hypertrophy                                      8 (16%)      2 (4%)       3 (6%)       3 (6%)                                
      Necrosis                                         1 (2%)       4 (8%)                    1 (2%)                                
      Vacuolization Cytoplasmic                       27 (54%)     27 (55%)     31 (62%)     27 (54%)                               
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                      6 (12%)      8 (16%)     11 (22%)      5 (10%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (49)         (45)         (48)         (49)                                   
      Hyperplasia                                      2 (4%)       1 (2%)      19 (40%)     32 (65%)                               
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                      4 (8%)      10 (20%)     11 (22%)      3 (6%)                                
      Cyst                                             6 (12%)      3 (6%)       1 (2%)       5 (10%)                               
      Hyperplasia                                     16 (32%)     21 (42%)     12 (24%)     13 (26%)                               
      Inflammation                                                  1 (2%)                    1 (2%)                                
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Ultimobranchial Cyst                                                       2 (4%)       1 (2%)                                
      C-Cell, Hyperplasia                             17 (34%)      8 (16%)      8 (16%)      5 (10%)                               
      Follicle, Cyst                                                1 (2%)                                                          
      Follicle, Degeneration                           1 (2%)       2 (4%)                                                          
      Follicular Cell, Hyperplasia                                  1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation                                     3 (6%)                    4 (8%)       1 (2%)                                
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation                                     2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Duct, Cyst                                                                 1 (2%)       1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                          4 (8%)       7 (14%)      8 (16%)      4 (8%)                                
      Hyperplasia                                      2 (4%)       3 (6%)       4 (8%)                                             
      Inflammation                                    18 (36%)     17 (34%)     26 (52%)     26 (52%)                               
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                          3 (6%)       7 (14%)      8 (16%)      4 (8%)                                
      Inflammation                                     1 (2%)                    1 (2%)       1 (2%)                                
      Mineralization                                                                          4 (8%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)                    1 (2%)                                
      Necrosis                                                      2 (4%)                                                          
      Germinal Epithelium, Degeneration                6 (12%)      5 (10%)      6 (12%)      7 (14%)                               
      Interstitial Cell, Hyperplasia                  15 (30%)     12 (24%)     14 (28%)     22 (44%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Hyperplasia, Megakaryocyte                                    1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)       2 (4%)                                
      Myelofibrosis                                                 1 (2%)       2 (4%)       2 (4%)                                
      Necrosis                                                      1 (2%)                                                          
      Erythroid Cell, Hyperplasia                     13 (26%)      3 (6%)      10 (20%)     10 (20%)                               
      Myeloid Cell, Hyperplasia                       21 (42%)     27 (55%)     20 (40%)     14 (28%)                               
   Lymph Node                                         (19)         (20)         (16)         (19)                                   
      Deep Cervical, Ectasia                           2 (11%)                                1 (5%)                                
      Deep Cervical, Infiltration Cellular, Plasma                                                                                  
        Cell                                           1 (5%)       2 (10%)                   2 (11%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Ectasia                             3 (16%)                   4 (25%)      3 (16%)                               
      Mediastinal, Hemorrhage                          1 (5%)                    1 (6%)       2 (11%)                               
      Mediastinal, Hyperplasia                                                   1 (6%)       2 (11%)                               
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                                        1 (5%)       2 (13%)      3 (16%)                               
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                     2 (11%)                                                                      
      Mediastinal, Inflammation                                                  1 (6%)                                             
      Pancreatic, Ectasia                                                        2 (13%)      2 (11%)                               
      Pancreatic, Hemorrhage                                                     1 (6%)       1 (5%)                                
      Pancreatic, Infiltration Cellular, Histiocyte    1 (5%)       1 (5%)       2 (13%)                                            
      Pancreatic, Inflammation                                                   3 (19%)      1 (5%)                                
      Renal, Ectasia                                                                          1 (5%)                                
      Renal, Infiltration Cellular, Histiocyte                                                1 (5%)                                
   Lymph Node, Mandibular                             (5)          (1)          (2)                                                 
      Ectasia                                          1 (20%)                                                                      
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                 6 (12%)                               
      Ectasia                                          4 (8%)       2 (4%)       5 (10%)      4 (8%)                                
      Infiltration Cellular, Histiocyte               47 (94%)     41 (82%)     48 (96%)     46 (92%)                               
      Inflammation                                     1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                              1 (2%)                                                          
      Autolysis                                                     1 (2%)                                                          
      Fibrosis                                         1 (2%)                    3 (6%)       1 (2%)                                
      Hematopoietic Cell Proliferation                45 (90%)     42 (84%)     45 (90%)     41 (82%)                               
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            6 (12%)      2 (4%)       9 (18%)      4 (8%)                                
      Inflammation, Granulomatous                      1 (2%)       3 (6%)       7 (14%)      1 (2%)                                
      Necrosis                                         1 (2%)       2 (4%)                    1 (2%)                                
      Pigmentation, Hemosiderin                       39 (78%)     43 (86%)     44 (88%)     43 (86%)                               
      Lymphoid Follicle, Atrophy                       1 (2%)                    1 (2%)       2 (4%)                                
   Thymus                                             (48)         (48)         (48)         (48)                                   
      Atrophy                                         44 (92%)     42 (88%)     47 (98%)     46 (96%)                               
      Ectopic Parathyroid Gland                                     1 (2%)                    4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Galactocele                                      2 (4%)                    1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation                                     2 (4%)                                                                       
      Subcutaneous Tissue, Inflammation                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                                     1 (2%)       4 (8%)                                
      Osteosclerosis                                                             1 (2%)                                             
   Skeletal Muscle                                    (2)          (2)          (1)                                                 
      Degeneration                                     1 (50%)      1 (50%)      1 (100%)                                           
      Inflammation                                     1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       5 (10%)      5 (10%)      2 (4%)       5 (10%)                               
      Necrosis                                         2 (4%)       4 (8%)                                                          
   Peripheral Nerve                                   (1)                                                                           
      Infiltration Cellular, Mononuclear Cell          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)                                   
      Inflammation, Acute                              2 (4%)       2 (4%)       5 (10%)      7 (14%)                               
      Inflammation, Granulomatous                      2 (4%)       4 (8%)       5 (10%)      2 (4%)                                
      Metaplasia, Squamous                                                                    1 (2%)                                
      Mineralization                                                             2 (4%)      10 (20%)                               
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                16 (32%)      5 (10%)     13 (26%)      7 (14%)                               
      Alveolus, Infiltration Cellular, Histiocyte     46 (92%)     47 (96%)     49 (98%)     50 (100%)                              
      Bronchiole, Hyperplasia                          1 (2%)       3 (6%)                                                          
      Interstitium, Fibrosis                                        2 (4%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation                                     7 (14%)      7 (14%)      8 (16%)      9 (18%)                               
      Thrombosis                                       1 (2%)       2 (4%)       1 (2%)                                             
      Olfactory Epithelium, Degeneration               1 (2%)                                                                       
      Olfactory Epithelium, Metaplasia                 1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:17:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Hyperplasia              1 (2%)                    1 (2%)                                             
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Inflammation                                     2 (4%)       1 (2%)       8 (16%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Anterior Chamber, Inflammation                                                          1 (2%)                                
      Ciliary Body, Inflammation                                                 1 (2%)                                             
      Cornea, Inflammation                                                                    1 (2%)                                
      Iris, Fibrosis                                   1 (2%)                    1 (2%)                                             
      Iris, Inflammation                               1 (2%)                                 1 (2%)                                
      Lens, Cataract                                   2 (4%)                    1 (2%)                                             
      Lens, Mineralization                             1 (2%)                                                                       
      Retina, Atrophy                                  1 (2%)                                                                       
      Retina, Degeneration                             5 (10%)      2 (4%)       5 (10%)                                            
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphoid                  9 (18%)      4 (8%)       9 (18%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                    4 (8%)       1 (2%)       4 (8%)       2 (4%)                                
      Hyperplasia, Oncocytic                                                     1 (2%)                                             
      Infarct                                          1 (2%)       3 (6%)                                                          
      Nephropathy                                     50 (100%)    45 (90%)     50 (100%)    50 (100%)                              
      Artery, Inflammation                                                                    1 (2%)                                
      Cortex, Mineralization                                        1 (2%)       4 (8%)      14 (28%)                               
      Medulla, Mineralization                         47 (94%)     49 (98%)     47 (94%)     49 (98%)                               
      Papilla, Transitional Epithelium, Hyperplasia                                           1 (2%)                                
      Pelvis, Inflammation                                                       1 (2%)       1 (2%)                                
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)      11 (22%)     29 (58%)     34 (68%)                               
      Renal Tubule, Cyst                                                         1 (2%)       9 (18%)                               
      Renal Tubule, Hyperplasia                        1 (2%)       5 (10%)     20 (40%)     23 (46%)                               
      Renal Tubule, Pigmentation                       1 (2%)       1 (2%)       2 (4%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Calculus Gross Observation                                    1 (2%)       1 (2%)                                             
      Inflammation                                     3 (6%)                    2 (4%)       2 (4%)                                
      Muscularis, Degeneration                         1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   15                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.