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TDMS Study 05195-03 Pathology Tables

NTP Experiment-Test: 05195-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04
Route: DOSED WATER                                                                                                Time: 14:16:35




       Facility:  TSI Mason Research

       Chemical CAS #:  13410-01-0

       Lock Date:  02/16/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0       PPM
                               Include 001    0       PPM
                               Include 004    3.75    PPM
                               Include 003    3.75    PPM
                               Include 006    7.5     PPM
                               Include 005    7.5     PPM
                               Include 008    15      PPM
                               Include 007    15      PPM
                               Include 010    30      PPM
                               Include 009    30      PPM
                               Include 012    60      PPM
                               Include 011    60      PPM

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05195-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:16:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       9           
    Moribund Sacrifice                                                                                                  1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10                        
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (8)          (7)          (10)         (10)         (10)         
      Hematopoietic Cell Proliferation, Focal          7 (70%)      5 (63%)      3 (43%)      2 (20%)      3 (30%)                  
      Hepatodiaphragmatic Nodule                                    3 (38%)      5 (71%)      1 (10%)      1 (10%)                  
      Inflammation, Focal                                           2 (25%)                   1 (10%)      4 (40%)                  
      Necrosis, Multifocal                                                                                 2 (20%)      9 (90%)     
      Hepatocyte, Inclusion Body Intracytoplasmic,                                                                                  
         Focal                                                                                             1 (10%)                  
   Mesentery                                          (1)                       (1)                                                 
      Fat, Necrosis                                    1 (100%)                  1 (100%)                                           
   Pancreas                                           (10)                                                (10)         (10)         
      Atrophy                                                                                                           8 (80%)     
   Salivary Glands                                    (10)                                                (10)         (9)          
      Atrophy                                                                                                           9 (100%)    
   Stomach, Forestomach                               (10)         (1)          (1)                       (10)         (10)         
      Submucosa, Ectopic Tissue, Focal                              1 (100%)                                                        
   Stomach, Glandular                                 (10)                                                (10)         (10)         
      Mucosa, Hemorrhage, Focal                                                                                         7 (70%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)                                                (10)         (9)          
      Pars Nervosa, Developmental Malformation                                                             1 (10%)                  
   Thyroid Gland                                      (10)                                                (10)         (10)         
      Ectopic Thymus                                   1 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:16:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)                      (1)          (1)          (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
   Ovary                                              (10)         (1)                       (10)         (10)         (9)          
      Cyst                                             2 (20%)      1 (100%)                  2 (20%)                               
      Interstitium, Atrophy                                                                                5 (50%)      9 (100%)    
   Uterus                                             (10)         (2)                       (9)          (10)         (10)         
      Endometrium, Atrophy                                                                                10 (100%)     6 (60%)     
      Lumen, Dilatation                                             1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)                      (10)         (10)         (10)         (10)         
      Femoral, Depletion Cellular                                                             3 (30%)     10 (100%)    10 (100%)    
      Femoral, Inflammation, Focal, Subacute                                     1 (10%)                                            
      Femoral, Pigmentation, Hemosiderin                                                                                3 (30%)     
      Sternal, Depletion Cellular                                                                          1 (10%)                  
   Lymph Node                                         (1)                                    (1)          (1)                       
      Mediastinal, Hyperplasia, Lymphoid                                                      1 (100%)                              
      Pancreatic, Hyperplasia, Lymphoid                1 (100%)                                            1 (100%)                 
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)         (10)         (9)          
      Congestion                                                    1 (10%)      1 (10%)                                            
      Hyperplasia, Lymphoid                                                                   2 (20%)      1 (10%)                  
      Lymphocyte, Depletion Cellular                                                                                    8 (89%)     
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)         (10)         (9)          
      Hyperplasia, Lymphoid                                                                   2 (20%)      2 (20%)                  
      Lymphocyte, Depletion Cellular                                                                                    9 (100%)    
   Spleen                                             (10)                                                (10)         (10)         
      Lymphocyte, Depletion Cellular                                                                                   10 (100%)    
   Thymus                                             (10)                                                (10)         (9)          
      Depletion Lymphoid                                                                                                9 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (10)                                                (10)         (6)          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:16:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Atrophy                                                                                                           6 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (10)                      (10)         (10)         (10)         (10)         
      Distal, Femur, Metaphysis, Atrophy                                                                   9 (90%)     10 (100%)    
      Sternum, Developmental Malformation                                                                  1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (2)          (1)                       (10)         (10)         
      Edema                                                                                                             1 (10%)     
      Inflammation, Acute, Focal                                    1 (50%)                                                         
      Inflammation, Focal, Subacute                                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (1)          (5)          (8)          (10)         (10)         
      Mineralization, Focal                            9 (90%)                                             4 (40%)      4 (40%)     
      Papilla, Degeneration                            1 (10%)      1 (100%)     5 (100%)     8 (100%)     7 (70%)      6 (60%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:16:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          20           20           20           20           20           20           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                      16           
    Moribund Sacrifice                                                                                                  4           
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           20           19           20           20                        
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (6)          (8)          (10)         (10)         (10)         
      Fatty Change                                                                            1 (10%)      1 (10%)                  
      Hematopoietic Cell Proliferation, Focal          4 (40%)      2 (33%)      4 (50%)      2 (20%)      4 (40%)                  
      Hepatodiaphragmatic Nodule                       2 (20%)      3 (50%)      3 (38%)                   1 (10%)                  
      Inflammation, Focal                                           1 (17%)      1 (13%)                   1 (10%)                  
      Necrosis, Multifocal                                                                                 3 (30%)      2 (20%)     
   Pancreas                                           (10)                                                (10)         (9)          
      Atrophy                                                                                                           6 (67%)     
   Salivary Glands                                    (10)                                                (9)          (9)          
      Atrophy                                                                                                           8 (89%)     
   Stomach, Forestomach                               (10)                      (3)          (1)          (10)         (10)         
      Mucosa, Erosion, Focal                                                     2 (67%)      1 (100%)                              
      Mucosa, Hyperplasia                                                                     1 (100%)                              
      Mucosa, Ulcer, Focal                                                       1 (33%)                                            
   Stomach, Glandular                                 (10)                                                (10)         (10)         
      Mucosa, Hemorrhage, Focal                                                                                         2 (20%)     
      Submucosa, Hemorrhage, Focal                                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (10)         (10)         
      Cardiomyopathy                                   5 (50%)                                             3 (30%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                (10)         (10)         
      Hyperplasia                                                                                                       2 (20%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:16:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                       10 (100%)                                            8 (80%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)                                                (10)         (10)         
      Lumen, Degeneration                                                                                               9 (90%)     
   Penis                                                                                                               (1)          
      Hemorrhage, Focal                                                                                                 1 (100%)    
   Preputial Gland                                    (10)         (1)                                    (10)         (10)         
      Atrophy                                                                                                           9 (90%)     
   Seminal Vesicle                                    (10)                                                (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
   Testes                                             (10)                                                (10)         (10)         
      Germinal Epithelium, Degeneration                                                                                 4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)                                   (10)         (10)         (10)         
      Femoral, Depletion Cellular                                                                          9 (90%)      9 (90%)     
      Femoral, Pigmentation, Hemosiderin                                                                                5 (50%)     
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)         (9)          (9)          
      Congestion                                       3 (30%)      1 (10%)      2 (20%)      2 (20%)                               
      Hyperplasia, Lymphoid                            1 (10%)                   1 (10%)                   1 (11%)                  
      Lymphocyte, Depletion Cellular                                                                                    7 (78%)     
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)         (10)         (6)          
      Congestion                                                                                           1 (10%)                  
      Hyperplasia, Lymphoid                                                      1 (10%)                                            
      Lymphocyte, Depletion Cellular                                                                                    5 (83%)     
   Spleen                                             (10)                                                (10)         (10)         
      Lymphocyte, Depletion Cellular                                                                                    7 (70%)     
   Thymus                                             (10)                                                (10)         (8)          
      Depletion Lymphoid                                                                                                8 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:16:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (10)                                   (10)         (10)         (10)         
      Distal, Femur, Metaphysis, Atrophy                                                                   3 (30%)      9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                                                 (2)          
      Infiltration Cellular, Polymorphonuclear                                                                          1 (50%)     
      Lens, Cataract                                                                                                    1 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                      (3)          (6)          (10)         (10)         
      Mineralization, Focal                                                                                             1 (10%)     
      Papilla, Degeneration                                                      3 (100%)     6 (100%)     6 (60%)      7 (70%)     
      Renal Tubule, Dilatation, Focal                  1 (10%)                                             1 (10%)      2 (20%)     
   Urinary Bladder                                    (10)                      (1)                       (10)         (10)         
      Calculus Gross Observation                                                 1 (100%)                                           
      Calculus Micro Observation Only                                            1 (100%)                                           
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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