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https://ntp.niehs.nih.gov/go/17725

TDMS Study 05135-05 Pathology Tables

NTP Experiment-Test: 05135-05               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:06




       Facility:  Battelle Northwest

       Chemical CAS #:  78-79-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05135-05               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          40           40           40           40           40           40           
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           30           29           30           30           30           
                                                                                                                                    
  Animals Examined Microscopically                    40           40           40           40           40           40           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Pharynx                                            (40)         (10)         (11)         (10)         (10)         (40)         
      Palate, Papilloma                                                                                                 1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (38)         (10)         (12)         (10)         (10)         (40)         
      Ganglioneuroma                                                             1 (8%)                                             
   Pituitary Gland                                    (40)         (18)         (14)         (14)         (14)         (40)         
      Adenoma                                          6 (15%)      7 (39%)      3 (21%)      4 (29%)      3 (21%)      8 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (40)         (10)         (12)         (10)         (11)         (40)         
      Mesothelioma Benign                                                        1 (8%)                                 1 (3%)      
      Mesothelioma NOS                                                                                     1 (9%)                   
   Testes                                             (40)         (40)         (40)         (40)         (39)         (40)         
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-05               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leukemia Mononuclear                                          2 (5%)                                                          
      Interstitial Cell, Adenoma                       3 (8%)       3 (8%)       4 (10%)      7 (18%)      8 (21%)      8 (20%)     
      Interstitial Cell, Adenoma, Multiple                                                                              1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (40)         (13)         (12)         (13)         (13)         (40)         
      Leukemia Mononuclear                                          2 (15%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (3)          (10)         (10)         (11)         (10)         (3)          
      Fibroadenoma                                                                            1 (9%)                                
   Skin                                               (40)         (10)         (11)         (12)         (10)         (40)         
      Sarcoma                                                                    1 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (40)         (40)         (40)         (40)         (40)         (40)         
      Alveolar/Bronchiolar Adenoma                     1 (3%)       1 (3%)                                              1 (3%)      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-05               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(40)        *(40)        *(40)        *(40)        *(40)        *(40)         
      Leukemia Mononuclear                                          2 (5%)                                                          
      Mesothelioma Benign                                                        1 (3%)                                 1 (3%)      
      Mesothelioma NOS                                                                                     1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-05               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             9          13          10          11          11          15               
     Total Primary Neoplasms                           10          13          10          12          12          20               
                                                                                                                                    
   Total Animals with Benign Neoplasms                  9          11           9          11          11          15               
     Total Benign Neoplasms                            10          11           9          12          11          20               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           2           1                                                   
     Total Malignant Neoplasms                                      2           1                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                  1                           
     Total Uncertain Neoplasms                                                                          1                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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