National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17727

TDMS Study 05135-05 Pathology Tables

NTP Experiment-Test: 05135-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:45




       Facility:  Battelle Northwest

       Chemical CAS #:  78-79-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05135-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          40           40           40           40           40           40           
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           30           29           30           30           30           
                                                                                                                                    
  Animals Examined Microscopically                    40           40           40           40           40           40           
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 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (40)         (10)         (10)         (10)         (10)         (40)         
      Hemorrhage, Multifocal                                                                                            1 (3%)      
      Inflammation, Multifocal, Suppurative                                                                             1 (3%)      
   Intestine Small, Ileum                             (40)         (10)         (10)         (10)         (10)         (40)         
      Hyperplasia, Lymphoid                                                                                             1 (3%)      
   Liver                                              (40)         (15)         (22)         (15)         (17)         (40)         
      Clear Cell Focus                                                           1 (5%)                                             
      Fatty Change                                     1 (3%)                    3 (14%)      4 (27%)                               
      Fatty Change, Focal                                                                                  1 (6%)                   
      Fatty Change, Multifocal                                                   2 (9%)       1 (7%)                                
      Fibrosis                                         1 (3%)                                              1 (6%)       1 (3%)      
      Fibrosis, Focal                                                                                      1 (6%)                   
      Fibrosis, Multifocal                             1 (3%)                    1 (5%)                                 1 (3%)      
      Hepatodiaphragmatic Nodule                       5 (13%)      9 (60%)      8 (36%)      4 (27%)      8 (47%)      6 (15%)     
      Inflammation                                     1 (3%)                                                                       
      Inflammation, Focal                                                                                               1 (3%)      
      Inflammation, Multifocal                         2 (5%)                                                                       
      Necrosis, Focal                                                            1 (5%)                                 1 (3%)      
      Necrosis, Multifocal                             1 (3%)                    2 (9%)                                 3 (8%)      
      Sinusoid, Congestion, Focal                                                                                       1 (3%)      
   Mesentery                                          (1)          (2)          (2)          (2)          (2)          (1)          
      Accessory Spleen                                                                                                  1 (100%)    
      Congestion                                                                 1 (50%)                                            
      Necrosis                                         1 (100%)     2 (100%)                  2 (100%)     2 (100%)                 
   Pancreas                                           (40)         (10)         (11)         (10)         (10)         (40)         
      Accessory Spleen                                                                                                  1 (3%)      
      Atrophy                                          8 (20%)                                                          9 (23%)     
      Atrophy, Focal                                   1 (3%)                                                                       
      Atrophy, Multifocal                              1 (3%)                                                           1 (3%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Focal, Mixed Cell         1 (3%)                                                                       
      Infiltration Cellular, Mixed Cell                2 (5%)                                                           2 (5%)      
   Stomach, Forestomach                               (40)         (10)         (10)         (10)         (10)         (40)         
      Infiltration Cellular, Mixed Cell                                                                                 1 (3%)      
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (40)         (10)         (11)         (10)         (10)         (40)         
      Cardiomyopathy                                   1 (3%)                                                          12 (30%)     
      Cardiomyopathy, Focal                            2 (5%)                                                                       
      Cardiomyopathy, Multifocal                      14 (35%)                                                          2 (5%)      
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (40)         (10)         (11)         (10)         (10)         (40)         
      Vacuolization Cytoplasmic, Focal                 1 (3%)                                                                       
   Islets, Pancreatic                                 (40)         (10)         (11)         (10)         (10)         (40)         
      Hyperplasia                                      4 (10%)                                                          6 (15%)     
   Pituitary Gland                                    (40)         (18)         (14)         (14)         (14)         (40)         
      Hemorrhage, Focal                                                                       1 (7%)                                
      Hyperplasia                                     11 (28%)      1 (6%)                                 1 (7%)      11 (28%)     
      Pars Distalis, Cyst                              1 (3%)                    1 (7%)                                 2 (5%)      
   Thyroid Gland                                      (40)         (10)         (10)         (10)         (10)         (40)         
      Cyst                                             2 (5%)                                                           3 (8%)      
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (40)         (10)         (12)         (10)         (11)         (40)         
      Hemorrhage                                       1 (3%)                                                                       
      Hypospermia                                      1 (3%)                                                                       
      Inflammation, Chronic                            1 (3%)                                                           1 (3%)      
   Preputial Gland                                    (39)         (10)         (10)         (12)         (10)         (40)         
      Hyperplasia                                      1 (3%)                                                                       
      Infiltration Cellular, Mixed Cell                2 (5%)                                 2 (17%)                   1 (3%)      
      Inflammation, Suppurative                        3 (8%)                                 2 (17%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Prostate                                           (40)         (10)         (11)         (10)         (10)         (40)         
      Corpora Amylacea                                 1 (3%)                                                           2 (5%)      
      Inflammation, Suppurative                                                                                         2 (5%)      
   Testes                                             (40)         (40)         (40)         (40)         (39)         (40)         
      Degeneration                                     1 (3%)                    1 (3%)                                             
      Granuloma                                                                  1 (3%)                                             
      Inflammation                                                               1 (3%)                                             
      Interstitial Cell, Hyperplasia                  26 (65%)     31 (78%)     31 (78%)     31 (78%)     32 (82%)     40 (100%)    
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)          (2)                                                              
      Pancreatic, Congestion                           1 (100%)     1 (50%)                                                         
   Lymph Node, Bronchial                              (32)         (10)         (11)         (10)         (11)         (37)         
      Congestion                                      17 (53%)                                                         19 (51%)     
      Hyperplasia                                      1 (3%)                                              1 (9%)       6 (16%)     
   Lymph Node, Mandibular                             (35)         (10)         (12)         (11)         (10)         (40)         
      Congestion                                       1 (3%)                                 1 (9%)                    3 (8%)      
      Hyperplasia                                      8 (23%)                   1 (8%)                                 5 (13%)     
   Lymph Node, Mediastinal                            (35)         (15)         (12)         (11)         (10)         (30)         
      Congestion                                      20 (57%)      3 (20%)      1 (8%)                    1 (10%)     17 (57%)     
      Hyperplasia                                      5 (14%)      4 (27%)      1 (8%)       1 (9%)                    8 (27%)     
      Pigmentation, Hemosiderin                        6 (17%)                                                          2 (7%)      
   Spleen                                             (40)         (13)         (12)         (13)         (13)         (40)         
      Accessory Spleen                                 2 (5%)       1 (8%)       1 (8%)       2 (15%)      3 (23%)      2 (5%)      
      Capsule, Hyperplasia, Lymphoid                                                          1 (8%)                                
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (3)          (10)         (10)         (11)         (10)         (3)          
      Hyperplasia                                      1 (33%)                                                          2 (67%)     
   Skin                                               (40)         (10)         (11)         (12)         (10)         (40)         
      Inflammation, Chronic                                                                   1 (8%)                                
      Subcutaneous Tissue, Hemorrhage                                            1 (9%)                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (40)         (11)         (11)         (10)         (10)         (40)         
      Hemorrhage                                                    1 (9%)                                                          
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (40)         (10)         (10)         (10)         (10)         (40)         
      Infiltration Cellular, Mixed Cell                1 (3%)                                                           3 (8%)      
   Lung                                               (40)         (40)         (40)         (40)         (40)         (40)         
      Congestion                                       1 (3%)                    1 (3%)                                             
      Fibrosis, Multifocal                                                       1 (3%)                                             
      Hemorrhage                                       5 (13%)     10 (25%)     11 (28%)     10 (25%)     10 (25%)      5 (13%)     
      Hemorrhage, Multifocal                          35 (88%)     30 (75%)     26 (65%)     24 (60%)     22 (55%)     35 (88%)     
      Alveolar Epithelium, Hyperplasia                 3 (8%)                                 1 (3%)                    1 (3%)      
      Alveolar Epithelium, Hyperplasia, Focal                                                              1 (3%)       2 (5%)      
      Alveolar Epithelium, Hyperplasia, Multifocal     2 (5%)      15 (38%)     13 (33%)     11 (28%)     11 (28%)      3 (8%)      
      Alveolus, Hemorrhage                             2 (5%)                                              1 (3%)       3 (8%)      
      Alveolus, Infiltration Cellular, Focal,                                                                                       
        Histiocyte                                     2 (5%)                    1 (3%)       1 (3%)       1 (3%)       1 (3%)      
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
         Histiocyte                                    2 (5%)      17 (43%)     18 (45%)     16 (40%)     15 (38%)     18 (45%)     
      Alveolus, Infiltration Cellular, Histiocyte                                1 (3%)                                 2 (5%)      
      Alveolus, Inflammation, Granulomatous                                                                             1 (3%)      
      Peribronchial, Hyperplasia, Focal, Lymphoid                   2 (5%)       3 (8%)                                 4 (10%)     
      Peribronchial, Hyperplasia, Lymphoid                                                                              1 (3%)      
      Peribronchial, Hyperplasia, Lymphoid,                                                                                         
        Multifocal                                     5 (13%)      8 (20%)      7 (18%)      7 (18%)      4 (10%)      1 (3%)      
      Perivascular, Hyperplasia, Focal, Lymphoid       1 (3%)       1 (3%)                    2 (5%)       2 (5%)       2 (5%)      
      Perivascular, Hyperplasia, Lymphoid,                                                                                          
        Multifocal                                    15 (38%)     23 (58%)     25 (63%)     20 (50%)     17 (43%)     23 (58%)     
   Nose                                               (40)         (10)         (11)         (10)         (10)         (40)         
      Turbinate, Hemorrhage                                                      1 (9%)                                             
      Turbinate, Infiltration Cellular, Multifocal,                                                                                 
         Mixed Cell                                                                                                     1 (3%)      
      Turbinate, Infiltration Cellular, Mixed Cell     1 (3%)                                                           1 (3%)      
      Turbinate, Inflammation, Suppurative             1 (3%)                                                           1 (3%)      
   Trachea                                            (40)         (10)         (10)         (11)         (10)         (40)         
      Infiltration Cellular, Mononuclear Cell,                                                                                      
         Multifocal                                                                                                     1 (3%)      
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:12:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (40)         (10)         (11)         (11)         (11)         (40)         
      Cataract                                                                                1 (9%)       1 (9%)                   
      Retina, Degeneration                                                                    1 (9%)       1 (9%)                   
   Harderian Gland                                    (5)                                                              (6)          
      Hemorrhage                                       1 (20%)                                                                      
      Hyperplasia, Lymphoid                            4 (80%)                                                          3 (50%)     
      Hyperplasia, Lymphoid, Multifocal                                                                                 3 (50%)     
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (40)         (10)         (12)         (12)         (16)         (40)         
      Nephropathy, Chronic                                                                    1 (8%)                                
      Bilateral, Cyst                                                                         1 (8%)                                
      Bilateral, Nephropathy, Chronic                 23 (58%)                   1 (8%)       1 (8%)       6 (38%)     29 (73%)     
   Urinary Bladder                                    (40)         (11)         (13)         (10)         (17)         (40)         
      Calculus Micro Observation Only                  2 (5%)                    3 (23%)                   5 (29%)     12 (30%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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