National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16729

TDMS Study 05135-06 Pathology Tables

NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53




       Facility:  Battelle Northwest

       Chemical CAS #:  78-79-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
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         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
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DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          40           40           40           40           40           40           
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            1            1            1            1            5           
    Natural Death                                      1            1            1            2            3            4           
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           28           28           27           26           21           
                                                                                                                                    
  Animals Examined Microscopically                    40           40           40           40           40           40           
                                                                                                                                    
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 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (40)         (40)         (39)         (40)         (40)         (38)         
      Hemangioma                                                                                           2 (5%)                   
      Hepatocellular Carcinoma                         3 (8%)       1 (3%)       3 (8%)       4 (10%)      1 (3%)       9 (24%)     
      Hepatocellular Carcinoma, Multiple               1 (3%)                                 1 (3%)       3 (8%)                   
      Hepatocellular Adenoma                           4 (10%)      3 (8%)       3 (8%)      12 (30%)     13 (33%)      5 (13%)     
      Hepatocellular Adenoma, Multiple                              1 (3%)       3 (8%)       3 (8%)       5 (13%)     11 (29%)     
      Lymphoma Malignant Histiocytic                                                          1 (3%)                                
      Lymphoma Malignant Lymphocytic                                                          1 (3%)       1 (3%)       1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Mesentery                                          (1)          (2)                       (2)          (4)          (2)          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (25%)                  
   Stomach, Forestomach                               (40)         (40)         (39)         (40)         (40)         (38)         
      Squamous Cell Carcinoma                                                                              2 (5%)       1 (3%)      
      Squamous Cell Papilloma                                                                 2 (5%)       2 (5%)       4 (11%)     
      Squamous Cell Papilloma, Multiple                                                                                 1 (3%)      
   Tooth                                              (1)                       (2)                                                 
      Odontoma                                         1 (100%)                  1 (50%)                                            
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NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (40)         (12)         (11)         (13)         (40)         (38)         
      Lymphoma Malignant Lymphocytic                                                                                    1 (3%)      
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (40)         (12)         (11)         (13)         (40)         (38)         
      Lymphoma Malignant Lymphocytic                                                          1 (8%)       1 (3%)                   
   Lymph Node, Bronchial                              (32)         (11)         (10)         (11)         (35)         (32)         
      Lymphoma Malignant Histiocytic                                                          1 (9%)                                
      Lymphoma Malignant Lymphocytic                   1 (3%)                                 1 (9%)       1 (3%)       1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Lymph Node, Mandibular                             (24)         (7)          (10)         (11)         (33)         (23)         
      Lymphoma Malignant Lymphocytic                                                                       1 (3%)       1 (4%)      
   Lymph Node, Mesenteric                             (40)         (13)         (9)          (13)         (39)         (37)         
      Lymphoma Malignant Histiocytic                                                                                    1 (3%)      
      Lymphoma Malignant Lymphocytic                                                          1 (8%)       1 (3%)       1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Lymph Node, Mediastinal                            (19)         (10)         (7)          (9)          (20)         (22)         
      Lymphoma Malignant Histiocytic                                                          1 (11%)                               
      Lymphoma Malignant Lymphocytic                   1 (5%)                                 1 (11%)      1 (5%)       1 (5%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (5%)                   
   Spleen                                             (40)         (15)         (11)         (13)         (40)         (38)         
      Lymphoma Malignant Histiocytic                                                          1 (8%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Lymphoma Malignant Lymphocytic                                                          1 (8%)       1 (3%)       1 (3%)      
   Thymus                                             (40)         (12)         (11)         (13)         (39)         (36)         
      Lymphoma Malignant Histiocytic                                                          1 (8%)                                
      Lymphoma Malignant Lymphocytic                   1 (3%)                                 1 (8%)       1 (3%)       1 (3%)      
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (40)         (14)         (11)         (14)         (40)         (39)         
      Squamous Cell Papilloma                                                                 1 (7%)                                
      Sebaceous Gland, Adenoma                                                                1 (7%)                                
      Subcutaneous Tissue, Sarcoma                                                                                      1 (3%)      
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (40)         (40)         (39)         (40)         (40)         (38)         
      Lymphoma Malignant Lymphocytic                                                                                    1 (3%)      
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (40)         (12)         (11)         (13)         (40)         (38)         
      Meningioma Malignant, Metastatic, Spinal Cord                                                                     1 (3%)      
   Spinal Cord                                        (40)         (40)         (39)         (40)         (39)         (38)         
      Meningioma Malignant                                                                                              1 (3%)      
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (40)         (40)         (39)         (40)         (40)         (38)         
      Alveolar/Bronchiolar Adenoma                     2 (5%)       2 (5%)       1 (3%)       4 (10%)      8 (20%)      5 (13%)     
      Alveolar/Bronchiolar Adenoma, Multiple                                                               2 (5%)       4 (11%)     
      Alveolar/Bronchiolar Carcinoma                                                          1 (3%)                    3 (8%)      
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (3%)                   
      Lymphoma Malignant Histiocytic                                                          1 (3%)                                
      Lymphoma Malignant Lymphocytic                                                                                    1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Nose                                               (40)         (40)         (39)         (40)         (40)         (38)         
      Turbinate, Olfactory Epithelium, Lymphoma                                                                                     
          Malignant                                                                                        1 (3%)                   
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                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (40)         (40)         (39)         (40)         (40)         (38)         
      Adenoma                                          2 (5%)       6 (15%)      4 (10%)     13 (33%)     11 (28%)      7 (18%)     
      Adenoma, Multiple                                                                       1 (3%)       2 (5%)       5 (13%)     
      Carcinoma                                                                                            1 (3%)                   
      Lymphoma Malignant                                                                                   1 (3%)                   
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (40)         (13)         (11)         (14)         (40)         (38)         
      Bilateral, Lymphoma Malignant Lymphocytic                                               1 (7%)       1 (3%)       1 (3%)      
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(40)        *(40)        *(40)        *(40)        *(40)        *(40)         
      Lymphoma Malignant                                                                                   1 (3%)                   
      Lymphoma Malignant Histiocytic                                                          1 (3%)                    1 (3%)      
      Lymphoma Malignant Lymphocytic                   1 (3%)                                 1 (3%)       1 (3%)       1 (3%)      
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            12          12          11          25          26          25               
     Total Primary Neoplasms                           14          13          15          45          55          59               
                                                                                                                                    
   Total Animals with Benign Neoplasms                  9          11          10          23          25          24               
     Total Benign Neoplasms                             9          12          12          37          45          42               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               5           1           3           8           9          14               
     Total Malignant Neoplasms                          5           1           3           8          10          17               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                              1           1               
     Total Metastatic Neoplasm                                                                          6           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.