TDMS Study 93027-11 Pathology Tables
NTP Experiment-Test: 93027-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (DIBUTYL PHTHALATE) Date: 07/08/99 Route: DOSED FEED Time: 09:48:44 13 WEEK SUBCHRONIC Facility: Battelle Columbus Laboratory Chemical CAS #: 84-74-2 Lock Date: 06/12/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93027-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (DIBUTYL PHTHALATE) Date: 07/08/99 Route: DOSED FEED Time: 09:48:44 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 0 PPM 1000 2500 5000 10,000 20,000 PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) (10) Cytoplasmic Alteration 10 (100%) 10 (100%) Infiltration Cellular, Mononuclear Cell 5 (50%) 4 (40%) 7 (70%) 4 (40%) 4 (40%) 6 (60%) Necrosis 1 (10%) Pancreas (10) (10) (10) (10) (10) (10) Atrophy, Focal 1 (10%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Infiltration Cellular, Mononuclear Cell 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) Hypertrophy 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) (10) (10) (10) (10) Inflammation, Chronic 10 (100%) 7 (70%) 8 (80%) 9 (90%) 9 (90%) 10 (100%) Testes (10) (10) (10) (10) (10) (10) Atrophy 1 (10%) 1 (10%) 1 (10%) 3 (30%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (DIBUTYL PHTHALATE) Date: 07/08/99 Route: DOSED FEED Time: 09:48:44 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 0 PPM 1000 2500 5000 10,000 20,000 PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Hemorrhage, Focal 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) Nephropathy 9 (90%) 7 (70%) 9 (90%) 5 (50%) 6 (60%) 7 (70%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------