National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14619

TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04
Route: GAVAGE                                                                                                     Time: 13:48:23

                                                     53 WEEK SSAC FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/16/99 - 09/17/99

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 004    300 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 006    300 NG /3000 UG































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:48:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       300 NG /     300 NG /     300 NG /                                  
                                                   0 UG         100 UG       300 UG       3000 UG                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           80           98           80                                     
                                                                                                                                    
  Scheduled Sacrifice                                 13           10           13            9                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8           10            8            9                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (10)         (8)          (9)                                    
      Basophilic Focus                                              1 (10%)                   1 (11%)                               
      Eosinophilic Focus                                            1 (10%)      1 (13%)      1 (11%)                               
      Eosinophilic Focus, Multiple                                  1 (10%)                                                         
      Fatty Change, Diffuse                                         1 (10%)      3 (38%)      9 (100%)                              
      Fatty Change, Focal                                           1 (10%)                                                         
      Hepatodiaphragmatic Nodule                                    1 (10%)                                                         
      Infiltration Cellular, Histiocyte                                          1 (13%)                                            
      Inflammation                                     8 (100%)    10 (100%)     8 (100%)     9 (100%)                              
      Mixed Cell Focus                                 1 (13%)      1 (10%)                   3 (33%)                               
      Mixed Cell Focus, Multiple                       4 (50%)      8 (80%)      2 (25%)      3 (33%)                               
      Pigmentation                                                 10 (100%)     8 (100%)     9 (100%)                              
      Toxic Hepatopathy                                             3 (30%)                   6 (67%)                               
      Bile Duct, Fibrosis                                           1 (10%)                                                         
      Bile Duct, Hyperplasia                                        2 (20%)                   5 (56%)                               
      Hepatocyte, Hypertrophy                                      10 (100%)     8 (100%)     9 (100%)                              
      Hepatocyte, Multinucleated                                    3 (30%)      2 (25%)      7 (78%)                               
      Oval Cell, Hyperplasia                                        1 (10%)                   2 (22%)                               
   Pancreas                                           (8)          (10)         (8)          (9)                                    
      Acinus, Atrophy                                                                         1 (11%)                               
      Acinus, Hyperplasia                                                                     1 (11%)                               
      Acinus, Vacuolization Cytoplasmic                                                       6 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:48:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       300 NG /     300 NG /     300 NG /                                  
                                                   0 UG         100 UG       300 UG       3000 UG                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Cortex                                     (8)          (10)         (8)          (9)                                    
      Degeneration, Cystic                             2 (25%)      1 (10%)      1 (13%)      1 (11%)                               
      Hyperplasia                                      1 (13%)      3 (30%)      1 (13%)      1 (11%)                               
      Hypertrophy                                      4 (50%)      5 (50%)      5 (63%)      3 (33%)                               
      Vacuolization Cytoplasmic                                                               1 (11%)                               
   Thyroid Gland                                      (8)          (10)         (8)          (9)                                    
      C-Cell, Hyperplasia                              2 (25%)                                1 (11%)                               
      Follicular Cell, Hypertrophy                                  7 (70%)      6 (75%)      6 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (10)         (8)          (9)                                    
      Atrophy                                          7 (88%)      8 (80%)      7 (88%)      8 (89%)                               
      Cyst                                             1 (13%)                   1 (13%)                                            
      Inflammation, Suppurative                                                               1 (11%)                               
   Uterus                                             (8)          (10)         (8)          (9)                                    
      Inflammation, Suppurative                                                               6 (67%)                               
      Metaplasia, Squamous                             7 (88%)      9 (90%)      7 (88%)      7 (78%)                               
      Endometrium, Hyperplasia, Cystic                 5 (63%)                                2 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                    (9)                                    
      Pigmentation                                     8 (100%)                               9 (100%)                              
   Thymus                                             (8)          (10)         (8)          (9)                                    
      Atrophy                                          5 (63%)     10 (100%)     8 (100%)     9 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (2)          (5)          (9)                                    
      Cyst                                             1 (13%)                   2 (40%)                                            
      Hyperplasia                                      4 (50%)                   1 (20%)                                            
      Inflammation, Granulomatous                                                1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:48:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       300 NG /     300 NG /     300 NG /                                  
                                                   0 UG         100 UG       300 UG       3000 UG                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (10)         (8)          (9)                                    
      Infiltration Cellular, Histiocyte                4 (50%)                   2 (25%)      4 (44%)                               
      Alveolar Epithelium, Hyperplasia                              1 (10%)                                                         
      Alveolar Epithelium, Metaplasia, Bronchiolar                  3 (30%)      1 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                                          (1)                                                              
      Mineralization                                                1 (100%)                                                        
      Nephropathy                                                   1 (100%)                                                        
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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