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TDMS Study 89009-01 Pathology Tables

NTP Experiment-Test: 89009-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                       Date: 10/18/04
Route: DOSED WATER                                                                                                Time: 09:54:37




       Facility:  Southern Research Institute

       Chemical CAS #:  PESTFERTMIX2

       Lock Date:  05/22/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 89009-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 09:54:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          40           40           40           40           40                        
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                                                                          1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           30           30           30           29                        
                                                                                                                                    
  Animals Examined Microscopically                    20           20           20           20           20                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (20)         (20)         (20)         (20)         (20)                      
      Parasite Metazoan                                                                       1 (5%)                                
   Intestine Large, Rectum                            (20)         (20)         (19)         (20)         (20)                      
      Parasite Metazoan                                1 (5%)                                 2 (10%)      3 (15%)                  
   Liver                                              (20)         (20)         (20)         (20)         (20)                      
      Hepatodiaphragmatic Nodule                       1 (5%)                    1 (5%)       1 (5%)                                
   Mesentery                                                       (2)                       (1)          (1)                       
      Accessory Spleen                                                                                     1 (100%)                 
      Fat, Necrosis                                                 2 (100%)                  1 (100%)                              
   Stomach, Forestomach                               (20)         (20)         (20)         (20)         (20)                      
      Mucosa, Hyperplasia                                                        1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (20)         (20)         (20)         (20)         (20)                      
      Accessory Adrenal Cortical Nodule                                                                    1 (5%)                   
   Pituitary Gland                                    (19)         (20)         (20)         (20)         (20)                      
      Cyst                                                          1 (5%)       1 (5%)                    1 (5%)                   
      Pars Distalis, Hyperplasia, Focal                1 (5%)                                                                       
   Thyroid Gland                                      (20)         (20)         (20)         (20)         (20)                      
      Ultimobranchial Cyst                             4 (20%)                   2 (10%)      3 (15%)      1 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 89009-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 09:54:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (20)         (20)         (20)         (20)         (20)                      
      Cyst                                             1 (5%)                                              1 (5%)                   
   Uterus                                             (20)         (20)         (20)         (20)         (20)                      
      Hydrometra                                       4 (20%)      3 (15%)      2 (10%)      5 (25%)      5 (25%)                  
      Inflammation, Suppurative                        1 (5%)                                                                       
      Endometrium, Hyperplasia, Cystic                                                        1 (5%)       1 (5%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 89009-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 09:54:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 89009-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 09:54:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          40           40           40           40           40                        
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           30           30           29           30                        
                                                                                                                                    
  Animals Examined Microscopically                    20           20           20           20           20                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (20)         (20)         (20)         (20)         (20)                      
      Parasite Metazoan                                             1 (5%)                                                          
   Intestine Large, Rectum                            (20)         (20)         (20)         (20)         (20)                      
      Parasite Metazoan                                1 (5%)       4 (20%)      1 (5%)       2 (10%)      2 (10%)                  
   Liver                                              (20)         (20)         (20)         (20)         (20)                      
      Fibrosis, Focal                                               1 (5%)                    1 (5%)                                
      Hepatodiaphragmatic Nodule                       2 (10%)      1 (5%)                    1 (5%)       2 (10%)                  
   Mesentery                                          (1)                       (1)                       (2)                       
      Inflammation, Chronic, Focal                                                                         1 (50%)                  
      Fat, Necrosis                                    1 (100%)                  1 (100%)                  1 (50%)                  
   Pancreas                                           (20)         (20)         (20)         (20)         (20)                      
      Atrophy, Focal                                   3 (15%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (20)         (20)         (20)         (20)                      
      Artery, Inflammation, Chronic                                                                        2 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (20)         (20)         (20)         (20)         (20)                      
      Accessory Adrenal Cortical Nodule                             1 (5%)       1 (5%)                                             
   Pituitary Gland                                    (20)         (19)         (20)         (20)         (20)                      
      Cyst                                             1 (5%)                                              1 (5%)                   
      Pars Distalis, Focal Cellular Change             1 (5%)                                 1 (5%)                                
   Thyroid Gland                                      (20)         (20)         (20)         (20)         (20)                      
      Ultimobranchial Cyst                             3 (15%)                                2 (10%)      2 (10%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 89009-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 09:54:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                    (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
   Preputial Gland                                    (20)         (20)         (20)         (20)         (20)                      
      Inflammation, Chronic                            2 (10%)                                2 (10%)      2 (10%)                  
   Prostate                                           (20)         (20)         (20)         (20)         (20)                      
      Inflammation, Suppurative                        1 (5%)       1 (5%)       3 (15%)                   3 (15%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                             (1)                       
      Mediastinal, Hemorrhage                                                                              1 (100%)                 
   Lymph Node, Mandibular                             (20)         (20)         (20)         (20)         (18)                      
      Hyperplasia                                                                                          1 (6%)                   
   Lymph Node, Mesenteric                             (20)         (20)         (20)         (20)         (20)                      
      Hyperplasia, Lymphoid                            1 (5%)                                                                       
   Thymus                                             (20)         (20)         (20)         (20)         (20)                      
      Hemorrhage                                       2 (10%)                                             1 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 89009-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 09:54:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (19)         (20)         (20)         (20)         (20)                      
      Hemorrhage, Focal                                                                                    1 (5%)                   
      Alveolar Epithelium, Hyperplasia                                                                     1 (5%)                   
   Nose                                               (20)         (20)         (20)         (20)         (20)                      
      Inflammation, Suppurative                                                  1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (20)         (20)         (20)                      
      Renal Tubule, Dilatation, Focal                               1 (5%)                                                          
   Urinary Bladder                                    (20)         (20)         (20)         (20)         (20)                      
      Calculus Gross Observation                                                                           1 (5%)                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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