TDMS Study 89009-01 Pathology Tables
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 09:54:37 Facility: Southern Research Institute Chemical CAS #: PESTFERTMIX2 Lock Date: 05/22/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 09:54:37 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 40 40 40 40 40 Scheduled Sacrifice 10 10 10 10 10 Early Deaths Natural Death 1 Survivors Terminal Sacrifice 30 30 30 30 29 Animals Examined Microscopically 20 20 20 20 20 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (20) (20) (20) (20) (20) Parasite Metazoan 1 (5%) Intestine Large, Rectum (20) (20) (19) (20) (20) Parasite Metazoan 1 (5%) 2 (10%) 3 (15%) Liver (20) (20) (20) (20) (20) Hepatodiaphragmatic Nodule 1 (5%) 1 (5%) 1 (5%) Mesentery (2) (1) (1) Accessory Spleen 1 (100%) Fat, Necrosis 2 (100%) 1 (100%) Stomach, Forestomach (20) (20) (20) (20) (20) Mucosa, Hyperplasia 1 (5%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (20) (20) (20) (20) (20) Accessory Adrenal Cortical Nodule 1 (5%) Pituitary Gland (19) (20) (20) (20) (20) Cyst 1 (5%) 1 (5%) 1 (5%) Pars Distalis, Hyperplasia, Focal 1 (5%) Thyroid Gland (20) (20) (20) (20) (20) Ultimobranchial Cyst 4 (20%) 2 (10%) 3 (15%) 1 (5%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 09:54:37 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (20) (20) (20) (20) (20) Cyst 1 (5%) 1 (5%) Uterus (20) (20) (20) (20) (20) Hydrometra 4 (20%) 3 (15%) 2 (10%) 5 (25%) 5 (25%) Inflammation, Suppurative 1 (5%) Endometrium, Hyperplasia, Cystic 1 (5%) 1 (5%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 09:54:37 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 09:54:37 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 40 40 40 40 40 Scheduled Sacrifice 10 10 10 10 10 Early Deaths Natural Death 1 Survivors Terminal Sacrifice 30 30 30 29 30 Animals Examined Microscopically 20 20 20 20 20 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (20) (20) (20) (20) (20) Parasite Metazoan 1 (5%) Intestine Large, Rectum (20) (20) (20) (20) (20) Parasite Metazoan 1 (5%) 4 (20%) 1 (5%) 2 (10%) 2 (10%) Liver (20) (20) (20) (20) (20) Fibrosis, Focal 1 (5%) 1 (5%) Hepatodiaphragmatic Nodule 2 (10%) 1 (5%) 1 (5%) 2 (10%) Mesentery (1) (1) (2) Inflammation, Chronic, Focal 1 (50%) Fat, Necrosis 1 (100%) 1 (100%) 1 (50%) Pancreas (20) (20) (20) (20) (20) Atrophy, Focal 3 (15%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (20) (20) (20) (20) (20) Artery, Inflammation, Chronic 2 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (20) (20) (20) (20) (20) Accessory Adrenal Cortical Nodule 1 (5%) 1 (5%) Pituitary Gland (20) (19) (20) (20) (20) Cyst 1 (5%) 1 (5%) Pars Distalis, Focal Cellular Change 1 (5%) 1 (5%) Thyroid Gland (20) (20) (20) (20) (20) Ultimobranchial Cyst 3 (15%) 2 (10%) 2 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 09:54:37 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ductus Deferens (1) Inflammation, Chronic 1 (100%) Preputial Gland (20) (20) (20) (20) (20) Inflammation, Chronic 2 (10%) 2 (10%) 2 (10%) Prostate (20) (20) (20) (20) (20) Inflammation, Suppurative 1 (5%) 1 (5%) 3 (15%) 3 (15%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Mediastinal, Hemorrhage 1 (100%) Lymph Node, Mandibular (20) (20) (20) (20) (18) Hyperplasia 1 (6%) Lymph Node, Mesenteric (20) (20) (20) (20) (20) Hyperplasia, Lymphoid 1 (5%) Thymus (20) (20) (20) (20) (20) Hemorrhage 2 (10%) 1 (5%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 09:54:37 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (19) (20) (20) (20) (20) Hemorrhage, Focal 1 (5%) Alveolar Epithelium, Hyperplasia 1 (5%) Nose (20) (20) (20) (20) (20) Inflammation, Suppurative 1 (5%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (20) (20) (20) (20) (20) Renal Tubule, Dilatation, Focal 1 (5%) Urinary Bladder (20) (20) (20) (20) (20) Calculus Gross Observation 1 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------