National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/15790

TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04
Route: GAVAGE                                                                                                     Time: 14:05:30

                                                     53 WEEK SSAC FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/16/99 - 09/17/99

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    10 NG / 10 UG
                               Include 003    100 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 007    1000 NG/1000 UG
































                                                              Page   1


NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8|                                   |      L     |
    0 UG                                   | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Inflammation                         |             1  1  1  1  1  1  1  1                                       |      8  1.0|
      Mixed Cell Focus                     |                   X                                                      |      1     |
      Mixed Cell Focus, Multiple           |                X     X     X  X                                          |      4     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +  +  +  +                                       |   8        |
      Degeneration, Cystic                 |                   2              3                                       |      2  2.5|
      Hyperplasia                          |                         2                                                |      1  2.0|
      Hypertrophy                          |             1        1  1     1                                          |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      C-Cell, Hyperplasia                  |                      2           1                                       |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8|                                   |      L     |
    0 UG                                   | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Atrophy                              |             4  4  4     4  4  4  4                                       |      7  4.0|
      Cyst                                 |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Metaplasia, Squamous                 |             2  2  2     2  1  2  3                                       |      7  2.0|
      Endometrium, Hyperplasia, Cystic     |                2  2     2  2  1                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Pigmentation                         |             1  1  2  1  2  2  1  2                                       |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Atrophy                              |             1     1     1  1     2                                       |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      Cyst                                 |             1                                                            |      1  1.0|
      Hyperplasia                          |             1  1  1              1                                       |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8|                                   |      L     |
    0 UG                                   | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Infiltration Cellular, Histiocyte    |                         1  2  1  1                                       |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                   |      A     |
    10 NG /                                | 0| 0| 0| 0| 1| 3| 3| 5| 5| 6| 6| 6| 7|                                   |      L     |
    10 UG                                  | 2| 6| 7| 9| 0| 0| 5| 0| 3| 6| 8| 9| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +              +  +  +  +                                    |   8        |
      Basophilic Focus                     |       X                       X     X                                    |      3     |
      Inflammation                         |    1  1  1  1              1  1  1  1                                    |      8  1.0|
      Mixed Cell Focus                     |                            X                                             |      1     |
      Mixed Cell Focus, Multiple           |    X  X  X  X                 X  X  X                                    |      7     |
      Pigmentation                         |       1                                                                  |      1  1.0|
      Hepatocyte, Hypertrophy              |             1              1                                             |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +              +  +  +  +                                    |   8        |
      Inflammation, Chronic Active         |                               1                                          |      1  1.0|
      Acinus, Atrophy                      |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +              +  +  +  +                                    |   8        |
      Degeneration, Cystic                 |             3                                                            |      1  3.0|
      Hyperplasia                          |          2                    2  1  1                                    |      4  1.5|
      Hypertrophy                          |    1                          2  1  1                                    |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +              +  +  +  +                                    |   8        |
      C-Cell, Hyperplasia                  |                                  1                                       |      1  1.0|
      Follicular Cell, Hypertrophy         |          1  1                                                            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +              +  +  +  +                                    |   8        |
      Atrophy                              |       4  4  4              4  4  4                                       |      6  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                   |      A     |
    10 NG /                                | 0| 0| 0| 0| 1| 3| 3| 5| 5| 6| 6| 6| 7|                                   |      L     |
    10 UG                                  | 2| 6| 7| 9| 0| 0| 5| 0| 3| 6| 8| 9| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +              +  +  +  +                                    |   8        |
      Metaplasia, Squamous                 |       2  3  3              2  2  3                                       |      6  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +              +  +  +  +                                    |   8        |
      Atrophy                              |    2  2  1  2              1  1  1  1                                    |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |       +     +                                                            |   2        |
      Cyst                                 |       2     2                                                            |      2  2.0|
      Hyperplasia                          |       1     1                                                            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +              +  +  +  +                                    |   8        |
      Infiltration Cellular, Histiocyte    |    2     2  1              1     1                                       |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    100 NG /                               | 0| 1| 1| 1| 2| 2| 2| 2| 3| 4| 5| 7| 8|                                   |      L     |
    100 UG                                 | 4| 7| 8| 9| 0| 6| 7| 8| 0| 9| 4| 2| 4|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +                                                |   8        |
      Basophilic Focus                     |          X                                                               |      1     |
      Infiltration Cellular, Histiocyte    |                      1                                                   |      1  1.0|
      Inflammation                         |    1  1  1  1  1  1  1  1                                                |      8  1.0|
      Mixed Cell Focus                     |       X     X  X  X                                                      |      4     |
      Mixed Cell Focus, Multiple           |                      X  X                                                |      2     |
      Pigmentation                         |    1  1  1  1     1     1                                                |      6  1.0|
      Hepatocyte, Hypertrophy              |          1  1                                                            |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +                                                |   8        |
      Hyperplasia                          |             2                                                            |      1  2.0|
      Hypertrophy                          |    1  2        1  1  1                                                   |      5  1.2|
      Vacuolization Cytoplasmic            |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +                                                |   8        |
      Follicular Cell, Hypertrophy         |    1     1     1  1                                                      |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +  +  +  +                                                |   8        |
      Atrophy                              |    4  4  4  4  4     4  4                                                |      7  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +                                                |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    100 NG /                               | 0| 1| 1| 1| 2| 2| 2| 2| 3| 4| 5| 7| 8|                                   |      L     |
    100 UG                                 | 4| 7| 8| 9| 0| 6| 7| 8| 0| 9| 4| 2| 4|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Metaplasia, Squamous                 |    4  3  2  3  2     4  3                                                |      7  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +  +  +  +                                                |   8        |
      Atrophy                              |    2  2  2  1  3  2  2  2                                                |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +                                                |   8        |
      Infiltration Cellular, Histiocyte    |       1  1  1  1     1                                                   |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7|                                   |      L     |
    300 UG                                 | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +        +  +  +  +                                       |   8        |
      Eosinophilic Focus                   |                         X                                                |      1     |
      Fatty Change, Diffuse                |                            1  1  1                                       |      3  1.0|
      Infiltration Cellular, Histiocyte    |             1                                                            |      1  1.0|
      Inflammation                         |       1  1  1  1        1  1  1  1                                       |      8  1.0|
      Mixed Cell Focus, Multiple           |                X                 X                                       |      2     |
      Pigmentation                         |       2  2  1  1        1  1  1  2                                       |      8  1.4|
      Hepatocyte, Hypertrophy              |       1  1  1  1        1  1  1  1                                       |      8  1.0|
      Hepatocyte, Multinucleated           |       1  1                                                               |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +        +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +        +  +  +  +                                       |   8        |
      Degeneration, Cystic                 |          2                                                               |      1  2.0|
      Hyperplasia                          |                            1                                             |      1  1.0|
      Hypertrophy                          |       2  3              1     1  1                                       |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +        +  +  +  +                                       |   8        |
      Follicular Cell, Hypertrophy         |       1     1  1        1     1  2                                       |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +        +  +  +  +                                       |   8        |
      Atrophy                              |          4  4  4        4  4  4  4                                       |      7  4.0|
      Cyst                                 |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7|                                   |      L     |
    300 UG                                 | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +        +  +  +  +                                       |   8        |
      Metaplasia, Squamous                 |          4  2  2        3  2  4  4                                       |      7  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +        +  +  +  +                                       |   8        |
      Atrophy                              |       2  3  3  2        2  2  3  2                                       |      8  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |          +  +  +              +  +                                       |   5        |
      Cyst                                 |          3                       3                                       |      2  3.0|
      Hyperplasia                          |          1                                                               |      1  1.0|
      Inflammation, Granulomatous          |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +        +  +  +  +                                       |   8        |
      Infiltration Cellular, Histiocyte    |             1                    1                                       |      2  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7|                                   |      L     |
    300 UG                                 | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |      A     |
    1000 NG/                               | 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 6| 7|                                   |      L     |
    1000 UG                                | 0| 1| 2| 3| 5| 1| 1| 2| 3| 5| 5| 8| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +  +  +                                             |   8        |
      Basophilic Focus                     |                   X                                                      |      1     |
      Cholangiofibrosis                    |    3                                                                     |      1  3.0|
      Eosinophilic Focus, Multiple         |    X  X     X     X  X  X  X                                             |      7     |
      Fatty Change, Diffuse                |    1  1  3  1     2  1  2  1                                             |      8  1.5|
      Fatty Change, Focal                  |    3                                                                     |      1  3.0|
      Hyperplasia, Nodular                 |    X  X                                                                  |      2     |
      Inflammation                         |    1  1  2  2     1  2  1  2                                             |      8  1.5|
      Mixed Cell Focus, Multiple           |             X                                                            |      1     |
      Necrosis                             |                            1                                             |      1  1.0|
      Pigmentation                         |    3  2  2  2     2  2  2  2                                             |      8  2.1|
      Toxic Hepatopathy                    |    3  2  1  1     2  2  1  1                                             |      8  1.6|
      Bile Duct, Fibrosis                  |             1                                                            |      1  1.0|
      Bile Duct, Hyperplasia               |    3  2  1  2     2  2  1  1                                             |      8  1.8|
      Hepatocyte, Hypertrophy              |    4  3  3  3     3  4  3  3                                             |      8  3.3|
      Hepatocyte, Multinucleated           |    2  1  2  2     2  2  2  2                                             |      8  1.9|
      Oval Cell, Hyperplasia               |                   1  2  1  1                                             |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +  +  +  +                                             |   8        |
      Inflammation, Chronic Active         |                   1                                                      |      1  1.0|
      Acinus, Atrophy                      |                   1                                                      |      1  1.0|
      Acinus, Vacuolization Cytoplasmic    |    1  1     1     1  1  1  1                                             |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   |    +                                                                     |   1        |
      Pericardium, Inflammation, Chronic   |                                                                          |            |
          Active                           |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +     +  +  +  +                                             |   8        |
      Hyperplasia                          |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |      A     |
    1000 NG/                               | 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 6| 7|                                   |      L     |
    1000 UG                                | 0| 1| 2| 3| 5| 1| 1| 2| 3| 5| 5| 8| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy                          |                   1  1                                                   |      2  1.0|
      Vacuolization Cytoplasmic            |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +  +  +  +                                             |   8        |
      Follicular Cell, Hypertrophy         |       1           1  1     1                                             |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +     +  +  +  +                                             |   8        |
      Atrophy                              |       4  3        4  4  4  4                                             |      6  3.8|
      Cyst                                 |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +     +  +  +  +                                             |   8        |
      Inflammation, Suppurative            |                      3                                                   |      1  3.0|
      Metaplasia, Squamous                 |    1              2        4                                             |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +  +  +  +                                             |   8        |
      Atrophy                              |    3  1  3  2     3  4  3  4                                             |      8  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:05:30    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |      A     |
    1000 NG/                               | 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 6| 7|                                   |      L     |
    1000 UG                                | 0| 1| 2| 3| 5| 1| 1| 2| 3| 5| 5| 8| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +  +  +  +                                             |   8        |
      Hemorrhage                           |                      1                                                   |      1  1.0|
      Infiltration Cellular, Histiocyte    |    2                                                                     |      1  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |       1           1  1                                                   |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.