Share This:
https://ntp.niehs.nih.gov/go/14617

TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:19:45

                                                     53 WEEK SSAC FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/16/99 - 09/17/99

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    10 NG / 10 UG
                               Include 003    100 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 007    1000 NG/1000 UG





























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:19:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           98           98                        
                                                                                                                                    
  Scheduled Sacrifice                                 13           13           13           13           13                        
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8            8            8            8                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)          (8)          (8)          (8)                       
      Basophilic Focus                                              3            1                         1                        
      Cholangiofibrosis                                                                                    1 [3.0]                  
      Eosinophilic Focus                                                                      1                                     
      Eosinophilic Focus, Multiple                                                                         7                        
      Fatty Change, Diffuse                                                                   3 [1.0]      8 [1.5]                  
      Fatty Change, Focal                                                                                  1 [3.0]                  
      Hyperplasia, Nodular                                                                                 2                        
      Infiltration Cellular, Histiocyte                                          1 [1.0]      1 [1.0]                               
      Inflammation                                     8 [1.0]      8 [1.0]      8 [1.0]      8 [1.0]      8 [1.5]                  
      Mixed Cell Focus                                 1            1            4                                                  
      Mixed Cell Focus, Multiple                       4            7            2            2            1                        
      Necrosis                                                                                             1 [1.0]                  
      Pigmentation                                                  1 [1.0]      6 [1.0]      8 [1.4]      8 [2.1]                  
      Toxic Hepatopathy                                                                                    8 [1.6]                  
      Bile Duct, Fibrosis                                                                                  1 [1.0]                  
      Bile Duct, Hyperplasia                                                                               8 [1.8]                  
      Hepatocyte, Hypertrophy                                       2 [1.0]      2 [1.0]      8 [1.0]      8 [3.3]                  
      Hepatocyte, Multinucleated                                                              2 [1.0]      8 [1.9]                  
      Oval Cell, Hyperplasia                                                                               4 [1.3]                  
   Pancreas                                           (8)          (8)          (8)          (8)          (8)                       
      Inflammation, Chronic Active                                  1 [1.0]                                1 [1.0]                  
      Acinus, Atrophy                                               1 [1.0]                                1 [1.0]                  
      Acinus, Vacuolization Cytoplasmic                                                                    7 [1.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                                                                                  (1)                       
      Pericardium, Inflammation, Chronic Active                                                            1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:19:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (8)          (8)          (8)          (8)                       
      Degeneration, Cystic                             2 [2.5]      1 [3.0]                   1 [2.0]                               
      Hyperplasia                                      1 [2.0]      4 [1.5]      1 [2.0]      1 [1.0]      1 [3.0]                  
      Hypertrophy                                      4 [1.0]      4 [1.3]      5 [1.2]      5 [1.6]      2 [1.0]                  
      Vacuolization Cytoplasmic                                                  1 [1.0]                   1 [1.0]                  
   Thyroid Gland                                      (8)          (8)          (8)          (8)          (8)                       
      C-Cell, Hyperplasia                              2 [1.5]      1 [1.0]                                                         
      Follicular Cell, Hypertrophy                                  2 [1.0]      4 [1.0]      6 [1.2]      4 [1.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (8)          (8)          (8)          (8)                       
      Atrophy                                          7 [4.0]      6 [4.0]      7 [4.0]      7 [4.0]      6 [3.8]                  
      Cyst                                             1 [2.0]                                1 [2.0]      1 [2.0]                  
   Uterus                                             (8)          (8)          (8)          (8)          (8)                       
      Inflammation, Suppurative                                                                            1 [3.0]                  
      Metaplasia, Squamous                             7 [2.0]      6 [2.5]      7 [3.0]      7 [3.0]      3 [2.3]                  
      Endometrium, Hyperplasia, Cystic                 5 [1.8]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                                           
      Pigmentation                                     8 [1.5]                                                                      
   Thymus                                             (8)          (8)          (8)          (8)          (8)                       
      Atrophy                                          5 [1.2]      8 [1.4]      8 [2.0]      8 [2.4]      8 [2.9]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (2)                       (5)          (1)                       
      Cyst                                             1 [1.0]      2 [2.0]                   2 [3.0]                               
      Hyperplasia                                      4 [1.0]      2 [1.0]                   1 [1.0]                               
      Inflammation, Granulomatous                                                             1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:19:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                  
                                                      0 UG         10 UG        100 UG       300 UG       1000 UG                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (8)          (8)          (8)          (8)                       
      Hemorrhage                                                                                           1 [1.0]                  
      Infiltration Cellular, Histiocyte                4 [1.3]      5 [1.4]      5 [1.0]      2 [1.0]      1 [2.0]                  
      Alveolar Epithelium, Metaplasia, Bronchiolar                                            1 [1.0]      3 [1.0]                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------