National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16651

TDMS Study 61938-01 Pathology Tables

NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22




       Facility:  Battelle Northwest

       Chemical CAS #:  5522-43-0

       Lock Date:  06/05/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1


NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Necrosis, Focal                      |       4                                                                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cardiomyopathy                       |             1  1        1  1                                             |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Alveolar Epithelium, Hyperplasia     |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                      |      A     |
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +     +        +                                             |   3        |
      Hepatodiaphragmatic Nodule           |                   X        X                                             |      2     |
      Inflammation, Chronic                |             3                                                            |      1  3.0|
      Necrosis, Focal                      |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                         +                                                |   1        |
      Hemorrhage                           |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                      |      A     |
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     |    1     1     1        1                                                |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1     1  1  1  1  1  1                                                |      8  1.0|
      Inflammation, Chronic Active         | 1     1  1        1  1                                                   |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                      |      A     |
    2.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                         +                                                |   1        |
      Hepatodiaphragmatic Nodule           |                         X                                                |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +                                                                     |   1        |
      Fibrosis                             |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     |       1  1           1  1                                                |      4  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                      |      A     |
    2.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |    1     1  1     1  1     1                                             |      6  1.0|
      Inflammation, Chronic Active         |                   1     1                                                |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                      |      A     |
    8.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +     +     +  +                                             |   4        |
      Hepatodiaphragmatic Nodule           |             X     X     X  X                                             |      4     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +                                                                  |   1        |
      Cyst                                 |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     | 3  2  1  1  3  1  1  2  2  1                                             |     10  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                      |      A     |
    8.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1     1  1  1  1  1  1  1                                             |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       | 1     1  1        1  1     2                                             |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |      A     |
    20.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                      +                                                   |   1        |
      Hepatodiaphragmatic Nodule           |                      X                                                   |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     | 3  1  2  2  2  3  1  2  2  2                                             |     10  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |      A     |
    20.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Hemorrhage                           | 1  1  1     1  1  1     1                                                |      7  1.0|
      Inflammation, Chronic Active         | 1                    3                                                   |      2  2.0|
      Bronchus, Metaplasia, Squamous       |                1  1                                                      |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       | 2  3  3  2  3  3  2  1  1  2                                             |     10  2.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |       X                                                                  |      1     |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
      Necrosis                             |                            4                                             |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cardiomyopathy                       | 1  1           1     1                                                   |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  M  M  +  +  +                                             |   7        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     | 3  3  3  3  3  2  2  3  3  3                                             |     10  2.8|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1  1  1  1  1  1  1  1                                                |      9  1.0|
      Inflammation, Chronic Active         |    1           1                                                         |      2  1.0|
      Bronchus, Metaplasia, Squamous       |       1     1  1                                                         |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       | 3  2  2  3  3  3  3  3  2  3                                             |     10  2.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |                      1                                                   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |                         X  X                                             |      2     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cardiomyopathy                       | 1  1     1     1     1  1                                                |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Hypospermia                          |    3  3  3  3  3  1  3  3  3                                             |      9  2.8|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 1  2  2  2  1  3  1  2  3  3                                             |     10  2.0|
      Mineralization                       |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Renal, Hemorrhage                    |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  +  +  M  M  +  +                                             |   5        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |    1     1     1        1  1                                             |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |      A     |
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +                                                               |   2        |
      Hepatodiaphragmatic Nodule           |       X  X                                                               |      2     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypospermia                          | 3  2  2  2  1  3  3  2  1  3                                             |     10  2.2|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2  2  2  2  2  2  2  3  2  2                                             |     10  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                      |      A     |
    0.5                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +        +  +  +  +  +  +  +                                             |   8        |
      Hemorrhage                           | 1        1  1  1  1  1  1  1                                             |      8  1.0|
      Inflammation, Chronic Active         |          1           2  1                                                |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    2.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +        +     +     +                                             |   4        |
      Hepatodiaphragmatic Nodule           |       X        X     X     X                                             |      4     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypospermia                          | 3  2  2  2  2  2  3  2  4  2                                             |     10  2.4|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 1  1  2  2  2  2  3  3  2  2                                             |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   1        |
      Renal, Hemorrhage                    |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                      +                                                   |   1        |
      Hemorrhage                           |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |                +                                                         |   1        |
      Hemorrhage                           |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    2.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     | 1  1  1  1              1                                                |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Inflammation, Chronic Active         |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                      |      A     |
    8.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                            +                                             |   1        |
      Hepatodiaphragmatic Nodule           |                            X                                             |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |   9        |
      Hypospermia                          | 2  2  2  1  2  2  3  3  2                                                |      9  2.1|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2  2  2  1  2  3  3  2  2  1                                             |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                      |      A     |
    8.0                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     | 1  1  2  2  1  3  2  2  2  2                                             |     10  1.8|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |    1  1  1  1  1  1  1  1  1                                             |      9  1.0|
      Inflammation, Chronic Active         |       1           1                                                      |      2  1.0|
      Bronchus, Metaplasia, Squamous       |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       | 2  2     1  1  1     2  1  1                                             |      8  1.4|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                      |      A     |
    20.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                         +                                                |   1        |
      Hepatodiaphragmatic Nodule           |                         X                                                |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypospermia                          | 2  3  3  2  4  3  3  1  3  3                                             |     10  2.7|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2  3  3  2  3  3  3  1  3  2                                             |     10  2.5|
      Mineralization                       |       1  1                                                               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   1        |
      Renal, Hemorrhage                    |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                      |      A     |
    20.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     | 2  3  3  2  2  1  2  2  2  2                                             |     10  2.1|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Inflammation, Chronic Active         |       1                                                                  |      1  1.0|
      Bronchus, Metaplasia, Squamous       | 1     1                                                                  |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       | 2  2  2  2  2  3  3  2  2  1                                             |     10  2.1|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |       X                                                                  |      1     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cardiomyopathy                       |    1     1           1  1                                                |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypospermia                          | 3  3  1  3  3  1  1  2  3  3                                             |     10  2.3|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2  3  1  2  3  1  2  2  3  3                                             |     10  2.2|
      Mineralization                       |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  M  +  +                                             |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  +  +  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  M  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epiglottis, Metaplasia, Squamous     | 3  3  3  2  1  3  2  2  3  3                                             |     10  2.5|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 61938-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:36:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                      |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      A     |
    50.0                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                      |      L     |
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Bronchus, Metaplasia, Squamous       |    1     1  1  1           1                                             |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       | 2  2  3  3  3  3  3  3  3  3                                             |     10  2.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          | 1        1     1     1     1                                             |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.