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https://ntp.niehs.nih.gov/go/17063

TDMS Study 96021-01 Pathology Tables


NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03
Route: GAVAGE                                                                                                     Time: 09:34:57

                                                            FINAL #3




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  35065-27-1

       Lock Date:  01/16/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1


NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|             
                                           | 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                             2            |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         3|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                2  1                  |             
      Basophilic Focus                     |                                                                X     X   |             
      Basophilic Focus, Multiple           |       X     X  X  X           X  X                 X              X      |             
      Clear Cell Focus                     |                                                                X  X      |             
      Clear Cell Focus, Multiple           |             X                                                            |             
      Eosinophilic Focus                   |                                                                X         |             
      Eosinophilic Focus, Multiple         |    X                                X                             X      |             
      Fatty Change, Diffuse                |       1                                      1                           |             
      Fatty Change, Focal                  |                   1                                   1                  |             
      Hematopoietic Cell Proliferation     |    2     1     1  1        1        1           2     1  1  1  1         |             
      Inflammation                         | 1  1  1  2  1  2  1     1  1  1  1     1  1  1  3  1  1  1  1  1  1  2  1|             
      Mixed Cell Focus                     |                         X                                   X        X  X|             
      Mixed Cell Focus, Multiple           |             X  X           X           X           X  X  X        X      |             
      Necrosis                             |       3        2                 2                    3                  |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Cyst                      |                   3                                                      |             
      Bile Duct, Fibrosis                  |                                                                      1   |             
      Bile Duct, Hyperplasia               |                   1                                2                     |             
      Centrilobular, Degeneration          |    2                             2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|             
                                           | 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +           +                 +  +  +     +        +     +     +  +  +|             
      Gingival, Hyperplasia, Squamous      |    1           1                 1  1  1     1        1     1     1  1  1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                         2|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           2                              |             
      Mineralization                       |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +           +        +  +     +  +  +  +  +        +     +  +     +  +|             
      Degeneration                         |                                                                          |             
      Peridontal Tissue, Inflammation      |    1           1        1  1     1  1  1  2  1        2     1  1     2  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  2              1  1        1  1     1     1     1        1      |             
      Mineralization                       |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2  1     2  1           1                       2     2     2  2     2|             
      Degeneration, Cystic                 |    2                                2           2        2        3      |             
      Hyperplasia                          | 3           3     3     2  1     2                 2     2  2     4     3|             
      Hypertrophy                          | 2  3        3  2  2     2  2  2     3  2  2  2  2  2  2  3     3  4  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|             
                                           | 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis                             |                                  3                                       |             
      Vacuolization Cytoplasmic            | 1           2     1                    1                                1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  2        2  2              2     1     1                    2     2  1|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                 1     1              2  2              3     2        2|             
      Cytoplasmic Alteration               |                                        1                             2   |             
      Pars Distalis, Hyperplasia           |       3     3     2        2  2        2                          2  3  3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2           3     3           2        2  2           1  2        2      |             
      Follicular Cell, Hyperplasia         |          2                                                               |             
      Follicular Cell, Hypertrophy         |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  1  2  2  1  2  1  1  2  2  2  1  2  3  1  1  1  1  2  2  2  2  2  3|             
      Duct, Cyst                           | 2  3  2  2  2  2  4  3  2  3     1     2  2  3  2     2  3  3  2  3  3  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4     4     4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 |                   2        2                                   2        2|             
      Interstitial Cell, Hyperplasia       |                                                                2         |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|             
                                           | 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation, Chronic Active         |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            | 2           1                                            2               |             
      Metaplasia, Squamous                 | 2     1  1  3     1        2  1                    2     4  3     2     1|             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2     2     3  2  3     3  3  2  1  2  3  1        3  2     2  2  3  3  2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3     3     3  2  3     3  3  2  4  2  3     4     2  3  3  4     3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +                       +                          +            |             
      Mediastinal, Congestion              |          2                       2                          2            |             
      Mediastinal, Hyperplasia, Histiocytic|          2                                                               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  2                                       |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                             3            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  2  3  2           2     3        2  2  2        2  2     2  2  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  1  3  2  2  2     2  2  2  2  3  1  3     4  1  3  2  2  2  1  1  1|             
      Pigmentation                         | 1     2  1  2  1  1     1  1  1  1  1  2  1  1  1  2  1  2  1     2  1  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Atrophy                              |    2  4  3     2  2     2  2  3  2  2  3  2  3     3     3  2        2  4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|             
                                           | 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                             4                                 |             
      Hyperplasia                          |                      1              3  1  1           1        1     2  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      3                                                   |             
      Necrosis                             |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  2     2  1  2     2  2     2  1  2  1  2     2     2  1  1  1  1  2|             
      Inflammation                         |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |       1           1     1  1           2                 1        1     2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1                                                            |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Septum, Inflammation                 |                                           1                              |             
      Turbinate, Inflammation              |                   1  1                    1                              |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Retina, Atrophy                      |                                           2                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|             
                                           | 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1        1     1        1        1  1     1  1  1  1        1  1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         X                    X                           |             
      Casts Protein                        |    1                                                           1         |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                           3                              |             
      Inflammation, Suppurative            |             1                                                            |             
      Mineralization                       |    1     1  1              1     2  1  1           1  1  1  1  1  1  1  1|             
      Nephropathy                          | 1     1     1  1  1     2  1           1     1     1  1           1  1  1|             
      Pelvis, Inflammation                 |                   2                                                      |             
      Transitional Epithelium, Hyperplasia |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   2     1           1                                    |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|             
                                           | 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|             
                                           | 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             3            |             
      Basophilic Focus                     | X        X                                                     X  X      |             
      Basophilic Focus, Multiple           |                                                                          |             
      Clear Cell Focus                     |                                                                X         |             
      Clear Cell Focus, Multiple           | X           X                                                            |             
      Eosinophilic Focus                   | X  X  X                                                                  |             
      Eosinophilic Focus, Multiple         |                   X                             X  X              X      |             
      Fatty Change, Diffuse                |                                     1                                    |             
      Fatty Change, Focal                  |                                                                1         |             
      Hematopoietic Cell Proliferation     |          1              1  1  1                 1     1     1        1  1|             
      Inflammation                         | 1  1  1  1  2  1     1     1  2     1  1  1  1  1     2        1  1  1  1|             
      Mixed Cell Focus                     |       X                       X                    X                    X|             
      Mixed Cell Focus, Multiple           | X  X     X  X  X           X        X  X     X  X              X         |             
      Necrosis                             |                               2                       3     2            |             
      Pigmentation                         |                      1                                                   |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Fibrosis                  |                               1                                          |             
      Bile Duct, Hyperplasia               |                            2                                             |             
      Centrilobular, Degeneration          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|             
                                           | 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|             
                                           | 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +              +        +  +  +  +  +              +               |             
      Gingival, Hyperplasia, Squamous      | 1  1  1              1        1  1  1  1  1              1               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  3              1                        |             
      Acinus, Atrophy                      |                                                 1                        |             
      Acinus, Hyperplasia                  |    3                       3                    2                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                   2                                            2         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |          1                    2                                         2|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +  +        +  +     +  +  +  +  +  +  +        +  +     +  +  +   |             
      Degeneration                         |                                                                          |             
      Peridontal Tissue, Inflammation      | 1  1  2  1        1        1  1  1  1  1  1  1        1  1     1  1  2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1                       1                    1              1  1  1  1|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2     1           2     2                    2     3        2     2  2|             
      Degeneration, Cystic                 |          2                 2        2                             2      |             
      Hyperplasia                          |       2        2                       2              2        3  2      |             
      Hypertrophy                          | 2  1  2  1  1  2  1  1  1  4  2  2  3  2  2  2  2  2  1  1  2  2  3  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|             
                                           | 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|             
                                           | 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 1     1                                2                       1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        4  2              2     2  4        2                       2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2                                                            |             
      Hyperplasia                          |             2                                                            |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                1     2  2        3        2      |             
      Cytoplasmic Alteration               |                                                                          |             
      Pars Distalis, Hyperplasia           | 2        3  1     2  2           2     3     3     2  3        2     3  2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  1        2           2           1     2                    2     1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         |                   1              4                             2     2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1  2  2  1  2  1  1  2  1  2  3  1  1  2  2  2  1  1     2  1  1  1|             
      Duct, Cyst                           | 2  2     2  3  3  2  1  2  3  3  3  2  3  1  2  2  2  3  3  2  3  2  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4     4     4  4     4  4  4  4  4  4  4  4  4|             
      Cyst                                 | 2           2        2        3  2  2        3                    1      |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|             
                                           | 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|             
                                           | 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                      3   |             
      Inflammation, Chronic Active         |                                                                2     4   |             
      Inflammation, Suppurative            |          2                                                  1            |             
      Metaplasia, Squamous                 |    3     2        2              4        2  2  2     2     2  4     4   |             
      Cervix, Hyperplasia, Stromal         |       3                                                                  |             
      Cervix, Inflammation, Suppurative    |                                     3                                    |             
      Endometrium, Hyperplasia, Cystic     | 2  2  2  3     3  2     4           2  2  3  3  2  3  4     2           1|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2  3        3     3     3  3  4           2     4     3        4  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Hyperplasia, Plasma Cell             | 3  3  3  2  2  2     2     3  2  3  2  3  2  2        2  2     3     2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1     2  1  1  1     2  1  3     3  1  1  1  1  1  2     2  1     3  2|             
      Pigmentation                         | 1  1     1  2  2  1  3  1  2  1        2  2  1  1  1  1  3  1  2  3  1  1|             
      Lymphoid Follicle, Atrophy           |                                           2                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  4        3  3  2  2  2     3     2  2     2  3  2  2     2  3     3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|             
                                           | 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|             
                                           | 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1  3     1  1     1        1  2        2  1  1           2              1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    | 2  2  2  1     1  1  2  2  2  2  1  1  2  2  2  2  1  2        1  2  2  1|             
      Inflammation                         |                         2                 3  2     2                     |             
      Alveolar Epithelium, Hyperplasia     | 1  1  1                    1  1        1     1  1  1  1              1   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                3                                                         |             
      Septum, Inflammation                 | 1                                                     2  2               |             
      Turbinate, Inflammation              | 1           1           1                 1              2               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                  3                                       |             
      Retina, Atrophy                      |    1                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|             
                                           | 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|             
                                           | 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1     1                       1     1  1        1        1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                 1                        |             
      Casts Protein                        |                               1                                          |             
      Cyst                                 |                                                    2                     |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1  2  1  1     1  1  1  1  1     1  1  1  1  1     1  1  1  1  1|             
      Nephropathy                          | 1  1  1     1     1  1  1  2     1     1  1  1        1  1     1  1  1   |             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1                                                  1  1     1  1|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 6| 3| 3|                                                                 |            |
                                           | 4| 1| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 UG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 3| 5| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |       1                                                                  |      5  1.8|
      Basophilic Focus                     | X  X                                                                     |      8     |
      Basophilic Focus, Multiple           |                                                                          |      8     |
      Clear Cell Focus                     |                                                                          |      3     |
      Clear Cell Focus, Multiple           |                                                                          |      3     |
      Eosinophilic Focus                   |       X                                                                  |      5     |
      Eosinophilic Focus, Multiple         |                                                                          |      7     |
      Fatty Change, Diffuse                |                                                                          |      3  1.0|
      Fatty Change, Focal                  |       1                                                                  |      4  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |     20  1.1|
      Inflammation                         | 1  1                                                                     |     44  1.2|
      Mixed Cell Focus                     |                                                                          |      8     |
      Mixed Cell Focus, Multiple           |    X  X                                                                  |     21     |
      Necrosis                             |                                                                          |      7  2.4|
      Pigmentation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 6| 3| 3|                                                                 |            |
                                           | 4| 1| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 UG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 3| 5| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Cyst                      | 3     2                                                                  |      3  2.7|
      Bile Duct, Fibrosis                  |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               | 2     2                                                                  |      5  1.8|
      Centrilobular, Degeneration          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  21        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     21  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |    2                                                                     |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  34        |
      Degeneration                         |    3                                                                     |      1  3.0|
      Peridontal Tissue, Inflammation      | 1  3                                                                     |     33  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  52        |
      Aorta, Mineralization                |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       | 1     1                                                                  |     22  1.1|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 6| 3| 3|                                                                 |            |
                                           | 4| 1| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 UG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 3| 5| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     21  1.9|
      Degeneration, Cystic                 |                                                                          |      9  2.1|
      Hyperplasia                          |       3                                                                  |     18  2.4|
      Hypertrophy                          | 2  2  2                                                                  |     48  2.1|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |       2                                                                  |     10  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |     18  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 2                                                                        |     15  2.0|
      Cytoplasmic Alteration               |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia           |    4                                                                     |     23  2.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Hyperplasia                  |    2  2                                                                  |     19  1.9|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
      Follicular Cell, Hypertrophy         |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 6| 3| 3|                                                                 |            |
                                           | 4| 1| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 UG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 3| 5| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 1  1  2                                                                  |     52  1.6|
      Duct, Cyst                           | 1  2  4                                                                  |     49  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4                                                                     |     47  4.0|
      Cyst                                 | 3  3                                                                     |     14  2.2|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  +                                                                  |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |    4                                                                     |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      5  1.6|
      Metaplasia, Squamous                 |                                                                          |     23  2.3|
      Cervix, Hyperplasia, Stromal         |                                                                          |      1  3.0|
      Cervix, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    2  2                                                                  |     37  2.4|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2  2  2                                                                  |     34  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Mediastinal, Congestion              |                                                                          |      3  2.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 6| 3| 3|                                                                 |            |
                                           | 4| 1| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 UG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 3| 5| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 2  3  2                                                                  |     37  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 1  1  1                                                                  |     46  1.7|
      Pigmentation                         | 3  1  2                                                                  |     47  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  48        |
      Atrophy                              |    3  2                                                                  |     38  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      2  3.0|
      Hyperplasia                          |    1  3                                                                  |     22  1.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 6| 3| 3|                                                                 |            |
                                           | 4| 1| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 UG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 3| 5| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  2  1                                                                  |     45  1.6|
      Inflammation                         |       2                                                                  |      6  2.2|
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |     20  1.1|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation      |    3                                                                     |      2  3.0|
      Septum, Inflammation                 |                                                                          |      4  1.5|
      Turbinate, Inflammation              |                                                                          |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Degeneration                         |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     20  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      3  1.0|
      Casts Protein                        |                                                                          |      3  1.0|
      Cyst                                 |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 1  1  1                                                                  |     40  1.1|
      Nephropathy                          | 1  1  1                                                                  |     34  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 6| 3| 3|                                                                 |            |
                                           | 4| 1| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 UG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 3| 5| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      8  1.1|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|             
                                           | 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                   2     2                                                |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                   X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Basophilic Focus                     |                      X     X                                             |             
      Basophilic Focus, Multiple           | X  X                             X                    X     X  X         |             
      Clear Cell Focus                     |                                                       X     X            |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                                           X                              |             
      Eosinophilic Focus, Multiple         |                                                                         X|             
      Fatty Change, Diffuse                |                                     1                             2  2   |             
      Hematopoietic Cell Proliferation     |    1        1  1        1  1     1     1           1                    1|             
      Inflammation                         | 1  1  1  1     2  1     1     2     1  1     2  1     1  1  1  1  1  2  1|             
      Mixed Cell Focus                     |                                                 X                        |             
      Mixed Cell Focus, Multiple           | X                                            X        X  X  X  X         |             
      Necrosis                             |    2           2           2           3                                 |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               |                                              2                           |             
      Centrilobular, Degeneration          |    3        3  2        1                                                |             
      Hepatocyte, Hypertrophy              |          1                                                              2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|             
                                           | 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                +        +           +              +  +        +         |             
      Gingival, Hyperplasia, Squamous      |                3        1                          1           1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                       2                 2|             
      Mineralization                       |                                                 1                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               1  1                 1        1            |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                         +           +  +           +  +        +         |             
      Peridontal Tissue, Inflammation      |                         1           1  1           1  2        2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2     1        1  1                          1        1     3      |             
      Inflammation                         |                                                                      3   |             
      Necrosis                             |                                                                      3   |             
      Thrombosis                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     2     1                       2        2        2  2  1  2         |             
      Degeneration, Cystic                 |             2                                2        3        1         |             
      Hematopoietic Cell Proliferation     |             1                                                            |             
      Hyperplasia                          | 2           1     2        3              2  3        3        2  2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|             
                                           | 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hypertrophy                          | 2     2  2        2        2  1  1  3     1  2  2     3  1  2  2     1  1|             
      Necrosis                             |                                                                   3      |             
      Vacuolization Cytoplasmic            |       1              3  1              1                                 |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                       3     2  2  3     2  2        3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +|             
      Fibrosis                             |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        3                 2                 3                          3|             
      Pars Distalis, Hyperplasia           |    2  3           1  3  2                 2           2  3  3     3      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      C-Cell, Hyperplasia                  |    2              2                 1        2        3  3  2     2      |             
      Follicular Cell, Hypertrophy         |                   3                                            2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  1  2  2        2  2     2  2  3  2  2  1  1  3  2  3  1  3  2  2  2  2|             
      Duct, Cyst                           | 2  2  4  3        3  2  1  3  2  3  2  3  2  2        3     3  4  3  1  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4        4  4  4  4     4  4     4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 |                                        2                 2               |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  M  +  M  +  M  M  M  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|             
                                           | 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                          2               |             
      Angiectasis                          |                                                                         3|             
      Hemorrhage                           |                            3                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                   2              2                                       |             
      Metaplasia, Squamous                 | 2                 3  2  3  4     1        3  1  2     2     2  1     1   |             
      Ulcer                                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2     2           1              3           2  2     1  3  1  3  3  2  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +                                      +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3  3  3  4  4  3  4  3  4  2     4  3     3  4     3  3  2     2  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                           +                              |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lumbar, Ectasia                      |                                           3                              |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2        3  2  2  3     2           2     2  2     2  2     2  2  2  2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  3  2  1  3  2  2     3  4  4  1  1  3  2  2  2  3  2  2  2           3|             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2  1  2  2  1  1  1  2  1  1     2  3  1  1  2  1  1  2  1  2  2  2      |             
      Lymphoid Follicle, Atrophy           |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     2     4     3     4  3        2     4  2  2  3  3  2  2  2  3  3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|             
                                           | 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Cyst                                 |                                                             3            |             
      Hemorrhage                           |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      3   |             
      Hyperplasia                          |    1  2  1  1     2                                            1        2|             
      Inflammation, Granulomatous          |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glial Cell, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  1     1        2  2              3     2  2  1  3  2     3  2  2  1  2|             
      Inflammation                         |                            1                                            2|             
      Alveolar Epithelium, Hyperplasia     | 2        1        1     3           1        1        1     2  1  2     2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                                          |             
      Inflammation                         |    2              1           2     4                                    |             
      Respiratory Epithelium,              |                                                                          |             
          Mineralization                   |                                                                          |             
      Septum, Inflammation                 |                2              2                                          |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
      Turbinate, Inflammation              |                2              2        1                                 |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|             
                             DAY ON TEST   | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|             
                                           | 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation                         | 1        1                                               1        1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                         3           1                                    |             
      Calculus Micro Observation Only      |                                     X                                    |             
      Casts Protein                        |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                      3   |             
      Mineralization                       | 1  1  1  1  1     1  1  1  1  1  1        1  1  1  1  1  1  1  1  1  1  1|             
      Necrosis                             |                                                                      3   |             
      Nephropathy                          | 1        1     1  1  1  2        1  1        1              1     2     1|             
      Pelvis, Dilatation                   |                         3                                                |             
      Pelvis, Inflammation                 |                      2           2                                       |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      2           2                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                      X                                                   |             
      Inflammation                         |                      3  2           1  1  2                              |             
      Transitional Epithelium, Hyperplasia |                      3                                                   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|             
                                           | 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                2         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                3         |             
      Basophilic Focus                     |                   X  X                                                   |             
      Basophilic Focus, Multiple           |                X        X              X  X                 X     X      |             
      Clear Cell Focus                     |                                                                   X      |             
      Clear Cell Focus, Multiple           |                                           X                          X   |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Fatty Change, Diffuse                |       2                                      1                          1|             
      Hematopoietic Cell Proliferation     |       1  1              1           1  1           1     1  2  2  1      |             
      Inflammation                         |       3  1     1  1  2     1  1  1  3     1  1  1  1  1  1              1|             
      Mixed Cell Focus                     |                      X                                X                  |             
      Mixed Cell Focus, Multiple           |    X        X  X        X  X        X  X  X  X                       X   |             
      Necrosis                             |       3                                         1                        |             
      Pigmentation                         |                      1                                                   |             
      Bile Duct, Cyst                      |                                     2                                2   |             
      Bile Duct, Fibrosis                  |                                                       1                  |             
      Bile Duct, Hyperplasia               |                                           2                          2   |             
      Centrilobular, Degeneration          |       3                             2           3           2            |             
      Hepatocyte, Hypertrophy              | 1  1                                                                    1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|             
                                           | 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +              +           +     +                    +  +      |             
      Gingival, Hyperplasia, Squamous      |          1              3           2     2                    1  2      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                    2                     |             
      Hyperplasia, Squamous                |          1                                         2                     |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         1           2           2                        |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +              +     +     +     +                    +  +      |             
      Peridontal Tissue, Inflammation      |          1              3     1     1     2                    1  1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      1     1  1        1           1        1        1  1|             
      Inflammation                         |                                  3                                       |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2     1  1  2     2  2  2  2  2     1  2           2              2   |             
      Degeneration, Cystic                 |                2  2  1  3  3  3  2                    2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                3  3  2  3  3  3  3     2  2     3     3     2  2     2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|             
                                           | 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hypertrophy                          | 2  3     2  2  2  3  2  1  2  2     1  3  2  2                    1  2   |             
      Necrosis                             |                2                                                         |             
      Vacuolization Cytoplasmic            |                         1        3     1  1                              |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1     1                    1        3  2                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3     3     2  3     2  3  1        2              3              3  2|             
      Pars Distalis, Hyperplasia           |                      2           2           1              1     2     3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      C-Cell, Hyperplasia                  |    2     2  2        3                 3     2        2              1   |             
      Follicular Cell, Hypertrophy         | 1     2        1     1        2                                1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2        2  2  3  2     2  1  2     2     3  2  1  2  3  2  2  1     1  1|             
      Duct, Cyst                           | 2        3     3  3     2  2  2           3  2  3  1  3  2  3  1  3     3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4     4     4  4  4     4  4  4  4  4     4  4     4  4  4     4  4  4|             
      Cyst                                 |                         3              2  3                 2            |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  +  +  M  M  M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     2                                    |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|             
                                           | 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                         3|             
      Inflammation, Chronic Active         |                                                                         3|             
      Inflammation, Suppurative            |                                     2           3     1                  |             
      Metaplasia, Squamous                 | 3  4     1     1  1  2     1        4        2        2  2  1     2  2  4|             
      Ulcer                                |                                                                         2|             
      Endometrium, Hyperplasia, Cystic     |          1     1  2     1  3     1     3     2  2     3  1  2     2  3   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        4        2  4  3     3  4  4  4     2  3  4     4  3  4  3     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                                                   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lumbar, Ectasia                      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                      2                                                   |             
      Mediastinal, Hyperplasia, Plasma Cell|                      2                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Hyperplasia, Plasma Cell             |    2  2  2  2  2     3     2  1  2  3  3  2        2  2        2     3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  4  3  2  1     2  2  1  2  1  4  2  2  2  3  3  1  2  3  3  2  2   |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2  1     1  2  3  2  1  1  1  2     1  1  1  1        2     1     1  2  3|             
      Lymphoid Follicle, Atrophy           |                   2              3              3                       2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  3     3     2  4  3  2  4  4  2  2  2     3           3     2  2  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|             
                                           | 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |          1  2  1     2  1  2  2     1  2  1     1  1           1     1   |             
      Inflammation, Granulomatous          |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glial Cell, Hyperplasia              |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1     1  2  2     1  1  2  2  2  2  2  2  1  1  2  1  1  1  2  1  1  1   |             
      Inflammation                         | 2                 3  1                                                  2|             
      Alveolar Epithelium, Hyperplasia     | 1        1  1           1  1        1  1     1     3        1            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation                         |                                                       2                  |             
      Respiratory Epithelium,              |                                                                          |             
          Mineralization                   |                                     2                                    |             
      Septum, Inflammation                 |                                                       2                  |             
      Squamous Epithelium, Hyperplasia     |                      2                                                   |             
      Turbinate, Inflammation              |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|             
                             DAY ON TEST   | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|             
                                           | 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation                         |          1     1                    1        2  1                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                  2                                       |             
      Calculus Micro Observation Only      |                X              X  X                                       |             
      Casts Protein                        |                                                                          |             
      Inflammation, Chronic Active         |                                     1           1                        |             
      Inflammation, Suppurative            |                            1                                             |             
      Mineralization                       |    1  1     1  1  1  1     1  1  1     1     1  4  1        1  1  1  1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          |    1     1  1  1           1  1        1  1           1           1  2   |             
      Pelvis, Dilatation                   |                                  2                                       |             
      Pelvis, Inflammation                 |                   2                                                  2   |             
      Renal Tubule, Hyperplasia            |                                           2                              |             
      Transitional Epithelium, Hyperplasia |                   2              1              2                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation                         | 1  3              2        1              1                          1   |             
      Transitional Epithelium, Hyperplasia |    2              2                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 2| 4|                                                              |            |
                             DAY ON TEST   | 9| 5| 6| 7|                                                              |            |
                                           | 0| 2| 1| 9|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    10 UG/KG                               | 8| 8| 8| 8|                                                              |      L     |
                                           | 3| 4| 5| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  54        |
      Muscularis, Inflammation             |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  54        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  54        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |      2  2.5|
      Basophilic Focus                     | X                                                                        |      5     |
      Basophilic Focus, Multiple           |                                                                          |     12     |
      Clear Cell Focus                     |                                                                          |      3     |
      Clear Cell Focus, Multiple           |                                                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Fatty Change, Diffuse                |          1                                                               |      7  1.4|
      Hematopoietic Cell Proliferation     | 1     1  1                                                               |     22  1.1|
      Inflammation                         | 1  1  1  1                                                               |     39  1.2|
      Mixed Cell Focus                     |                                                                          |      3     |
      Mixed Cell Focus, Multiple           |                                                                          |     16     |
      Necrosis                             |          1                                                               |      7  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 2| 4|                                                              |            |
                             DAY ON TEST   | 9| 5| 6| 7|                                                              |            |
                                           | 0| 2| 1| 9|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    10 UG/KG                               | 8| 8| 8| 8|                                                              |      L     |
                                           | 3| 4| 5| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Fibrosis                  |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      3  2.0|
      Centrilobular, Degeneration          |    2     3                                                               |     10  2.4|
      Hepatocyte, Hypertrophy              |                                                                          |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  12        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     10  1.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  54        |
      Degeneration                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  52        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  54        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      4  1.8|
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  54        |
      Mineralization                       | 1                                                                        |      8  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  13        |
      Peridontal Tissue, Inflammation      |                                                                          |     13  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +                                                               |  54        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  54        |
      Cardiomyopathy                       | 1                                                                        |     18  1.2|
      Inflammation                         |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 2| 4|                                                              |            |
                             DAY ON TEST   | 9| 5| 6| 7|                                                              |            |
                                           | 0| 2| 1| 9|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    10 UG/KG                               | 8| 8| 8| 8|                                                              |      L     |
                                           | 3| 4| 5| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |     23  1.7|
      Degeneration, Cystic                 |                                                                          |     12  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |    2                                                                     |     24  2.4|
      Hypertrophy                          | 2     1                                                                  |     35  1.9|
      Necrosis                             |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +                                                               |  54        |
      Hyperplasia                          | 2                                                                        |     14  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +                                                               |  46        |
      Fibrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |     16  2.5|
      Pars Distalis, Hyperplasia           | 3        2                                                               |     18  2.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  52        |
      Angiectasis                          |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 2                                                                        |     17  2.1|
      Follicular Cell, Hypertrophy         |       2                                                                  |      9  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +                                                               |  51        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 2| 4|                                                              |            |
                             DAY ON TEST   | 9| 5| 6| 7|                                                              |            |
                                           | 0| 2| 1| 9|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    10 UG/KG                               | 8| 8| 8| 8|                                                              |      L     |
                                           | 3| 4| 5| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation                         | 2  2  1  2                                                               |     45  1.9|
      Duct, Cyst                           | 3  4     3                                                               |     40  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +                                                               |  53        |
      Atrophy                              | 4  4  4  4                                                               |     43  4.0|
      Cyst                                 | 2                                                                        |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +                                                               |  38        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  54        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |          1                                                               |      6  1.8|
      Metaplasia, Squamous                 | 1                                                                        |     29  2.1|
      Ulcer                                |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 3        3                                                               |     29  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  54        |
      Hyperplasia                          | 4  4  4  3                                                               |     41  3.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   3        |
      Hyperplasia, Plasma Cell             |    3                                                                     |      1  3.0|
      Lumbar, Ectasia                      |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +                                                               |  52        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 2| 4|                                                              |            |
                             DAY ON TEST   | 9| 5| 6| 7|                                                              |            |
                                           | 0| 2| 1| 9|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    10 UG/KG                               | 8| 8| 8| 8|                                                              |      L     |
                                           | 3| 4| 5| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 3  1  4  2                                                               |     36  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  54        |
      Ectasia                              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  54        |
      Hematopoietic Cell Proliferation     | 4  3  3  3                                                               |     48  2.3|
      Necrosis                             |    2                                                                     |      1  2.0|
      Pigmentation                         |          1                                                               |     42  1.5|
      Lymphoid Follicle, Atrophy           |          2                                                               |      6  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  53        |
      Atrophy                              | 2  2     3                                                               |     38  2.7|
      Cyst                                 |                                                                          |      1  3.0|
      Hemorrhage                           |       2                                                                  |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  54        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          | 2        1                                                               |     23  1.4|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  54        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 2| 4|                                                              |            |
                             DAY ON TEST   | 9| 5| 6| 7|                                                              |            |
                                           | 0| 2| 1| 9|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    10 UG/KG                               | 8| 8| 8| 8|                                                              |      L     |
                                           | 3| 4| 5| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Glial Cell, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  54        |
      Infiltration Cellular, Histiocyte    |    1     1                                                               |     40  1.6|
      Inflammation                         | 2                                                                        |      7  1.9|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     21  1.4|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  54        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation                         |    1                                                                     |      6  2.0|
      Respiratory Epithelium,              |                                                                          |            |
          Mineralization                   |                                                                          |      1  2.0|
      Septum, Inflammation                 |                                                                          |      3  2.0|
      Squamous Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Turbinate, Inflammation              |                                                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +                                                               |  54        |
      Atrophy                              | 1                                                                        |      1  1.0|
      Inflammation                         |                                                                          |      9  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  54        |
      Accumulation, Hyaline Droplet        |                                                                          |      3  2.0|
      Calculus Micro Observation Only      |          X                                                               |      5     |
      Casts Protein                        | 1        2                                                               |      2  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 2| 4|                                                              |            |
                             DAY ON TEST   | 9| 5| 6| 7|                                                              |            |
                                           | 0| 2| 1| 9|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    10 UG/KG                               | 8| 8| 8| 8|                                                              |      L     |
                                           | 3| 4| 5| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Mineralization                       |    1     1                                                               |     42  1.1|
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy                          |                                                                          |     23  1.1|
      Pelvis, Dilatation                   |                                                                          |      2  2.5|
      Pelvis, Inflammation                 |                                                                          |      4  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Inflammation                         |                                                                          |     11  1.6|
      Transitional Epithelium, Hyperplasia |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|             
                                           | 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         1|             
      Basophilic Focus                     | X           X     X        X              X  X     X                 X   |             
      Basophilic Focus, Multiple           |                X     X                                X                  |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |       X                                                     X     X     X|             
      Eosinophilic Focus, Multiple         |    X                                   X           X           X     X   |             
      Fatty Change, Diffuse                | 1                    1                                                   |             
      Fatty Change, Focal                  |                                                          1               |             
      Hematopoietic Cell Proliferation     |             2  1  1        1     1              1                        |             
      Inflammation                         | 1  1  1  1     1  1  1  2     1  1  1     1  1     1  1  1  1  1  1  1   |             
      Mixed Cell Focus                     |                            X                          X           X      |             
      Mixed Cell Focus, Multiple           |    X  X  X              X     X           X  X              X  X     X  X|             
      Necrosis                             |                            2                                             |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Cyst                      |                                              3                           |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               |                                  1                                       |             
      Centrilobular, Degeneration          |             1                                                        2   |             
      Hepatocyte, Hypertrophy              |             1                                               1        2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|             
                                           | 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Serosa, Inflammation                 |                            3                                             |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Fat, Inflammation, Chronic Active    |                                                                3         |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |             +           +  +     +     +     +        +     +            |             
      Gingival, Hyperplasia, Squamous      |             1           2  1     1     1     1        1     1            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                            2        2                                    |             
      Serosa, Inflammation, Chronic Active |                            3                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |             1                    1              2                    1   |             
                                           |__________________________________________________________________________|             
   Tooth                                   |             +  +     +  +        +     +  +  +        +     +  +         |             
      Peridontal Tissue, Inflammation      |             1  1     1  1        1     1  1  1        1     1  1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1        1     1     1     1        1  1        1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2     1        1  1  2  1           2  2        2  2     2  1  3  2|             
      Degeneration, Cystic                 | 3     2  2              2                 2  2        3           2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|             
                                           | 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |       3  3  2           1        2        3  3     3  3  2  2     4  3   |             
      Hypertrophy                          | 2  2  2  1     2     2  2  2  3  2  2  2  1  1  1  2  2  2  2  2  2  2   |             
      Necrosis                             |                                                          2               |             
      Vacuolization Cytoplasmic            |                               1           2  2     2     2  2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          | 1     3        3  1     1                       1     2  1  3  2         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                    3        3     3                    3  3     2      |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                    2                     |             
      Pars Distalis, Hyperplasia           |       2           2                       2  3  2  2  2        1  2  3  1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2  1        3        2           4     2  2        1              2   |             
      Follicular Cell, Hypertrophy         |    2  2           2     2              3                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2     2  2  2        3     2  1     2  2  1  1  1  2  1  2     2  1  2   |             
      Duct, Cyst                           | 2  2     1  3  4     2     3        1     3  2     3  2  3  3  2     2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4        4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4     4|             
      Cyst                                 | 2     3  2        2        2        2                                   2|             
      Inflammation, Chronic Active         |                         4                                                |             
      Necrosis                             |       2                                                                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|             
                                           | 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                                                  |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                         4                                                |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             
      Inflammation, Chronic Active         |       1                                                                  |             
      Inflammation, Suppurative            |                                                 1                        |             
      Metaplasia, Squamous                 |       3  2        2  1           4     2  2           2        2         |             
      Endometrium, Hyperplasia, Cystic     | 2     2  2        2  3  3  1  4     4  2  3  3  2  2  2     4  1  4      |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2     3  2  4     3  3     4  2  2     2  4  4  2     4  3  2     2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                 +  +                     |             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                 3                        |             
      Lumbar, Ectasia                      |                                                 3  3                     |             
      Lumbar, Hemorrhage                   |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |       2                 3                                                |             
      Hyperplasia, Plasma Cell             |       2  2        2  2  3  2  2     2     2     2  2  2     3           2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  3  2  3  1  2  3  1  3  2  2  2  2  3  2  1  1  2  2  1  1  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|             
                                           | 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2  2  2  2  1  1     2  2  1  2     2  1  2  2  1  1  2  2  1  1  2  1  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  4  3  2  2  2     3  2  3  2  3  3     4  3        2     2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  1     1  1     1     1  1     1     1     1                 1  3   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    2  3  2  1        1  2  3  2  2     2  2     2        3  2  1  2  2  1|             
      Inflammation                         |                         2     2                                          |             
      Alveolar Epithelium, Hyperplasia     |       2  2              2  2  2                          1  1        1   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Goblet Cell, Hyperplasia             |                2              3                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Septum, Inflammation                 |                                                 1                    2   |             
      Turbinate, Inflammation              |                               1                                      2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|             
                                           | 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1                       1                          1           2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Calculus Micro Observation Only      |                               X        X                 X               |             
      Casts Protein                        |             1                                                            |             
      Degeneration                         |                                                 2                        |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1        1  1|             
      Nephropathy                          |    1  1        1        1     1     1  1     1              1  1         |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Degeneration           |                                                                      3   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                                1                 1   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|             
                                           | 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    UG/KG                                  | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                X                                       |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   1      |             
      Basophilic Focus                     |    X           X     X  X           X        X  X     X                  |             
      Basophilic Focus, Multiple           |       X           X                                X     X               |             
      Clear Cell Focus                     |       X        X                                                  X      |             
      Clear Cell Focus, Multiple           |                         X                                                |             
      Eosinophilic Focus                   |                                              X     X     X               |             
      Eosinophilic Focus, Multiple         |                                                                X     X   |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                               1                                      1   |             
      Hematopoietic Cell Proliferation     | 1  1     1                          1           1           1           1|             
      Inflammation                         | 1  1  1  1  1  1  1  1     1  1  1  1  1           1  2  1  1  1  1  1  2|             
      Mixed Cell Focus                     |                      X              X                          X     X   |             
      Mixed Cell Focus, Multiple           |       X        X  X     X  X  X  X        X                       X      |             
      Necrosis                             |    3                                            2     2  3              2|             
      Pigmentation                         |                                                                         2|             
      Bile Duct, Cyst                      |                2                                                         |             
      Bile Duct, Fibrosis                  |                                              1                           |             
      Bile Duct, Hyperplasia               |                                              1                           |             
      Centrilobular, Degeneration          |    3                                                                    3|             
      Hepatocyte, Hypertrophy              |                                              1  2                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|             
                                           | 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    UG/KG                                  | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Serosa, Inflammation                 |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +     +  +  +  +  +           +     +                           |             
      Gingival, Hyperplasia, Squamous      |          1     2  1  1  1  1           1     1                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   2      |             
      Inflammation, Chronic Active         |                                                                   1      |             
      Acinus, Atrophy                      |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                          2               |             
      Mineralization                       |                                     1  1                             1   |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +           +     +  +  +           +     +     +                     |             
      Peridontal Tissue, Inflammation      |    1           2     2  1  1           1     1     1                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1        1  1  1           1              1        1        1     1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2     2  2  3  1  2  2  2     1  2  2  3     2     2     2  2  2   |             
      Degeneration, Cystic                 |             2  2  3              3           1           3        3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|             
                                           | 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    UG/KG                                  | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |       3     3     3        2  2  3     2     3     2     3     3  3  2   |             
      Hypertrophy                          |    2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  1  2        1  2  2  2   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    1  2        2              1                    1           1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Hyperplasia                          |          3                 1  1        2                    2           2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2        1           2     2  3  2  2  2     3     2     3         |             
      Cyst                                 |                                                       2                  |             
      Cytoplasmic Alteration               |                                                                          |             
      Pars Distalis, Hyperplasia           | 2        2        3  1  4        4        3           3           3  3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2        1        2  2  2  2        3        2           2  3  3   |             
      Follicular Cell, Hypertrophy         |             2                             1     2                    1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  2  2  2  2  1  2  2  2  2  2  2  2  2        3     1  2  2  1  2   |             
      Duct, Cyst                           | 3  3     2  2  3     2     2  2  3  2  1  3     3  3     1  1  2  3      |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4  4  4  4  4  4  4  4  4  4  4     4  4        4  4  4  4  4  4   |             
      Cyst                                 | 2           2  2  3     2  2                 2     2                     |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|             
                                           | 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    UG/KG                                  | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  M  +  M  M  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    3                     |             
      Dilatation                           |                   3                                                      |             
      Inflammation, Chronic Active         |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                  3                 2  3                  |             
      Inflammation, Suppurative            |                   2  1                       3                    2      |             
      Metaplasia, Squamous                 | 4     2  1  2     4  2     2     3           3     4  3  1        3  2  2|             
      Endometrium, Hyperplasia, Cystic     |       2     3  1     3  3  3     1  3     2  2           1  2        1  4|             
                                           |__________________________________________________________________________|             
   Vagina                                  |          +                                         +                     |             
      Inflammation                         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  4     3  3  2     3  2        3  4  3  2  2  4  4  3  3  3  3  2  3  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              2                           |             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |             2  2           2  3  3  3  3  3  2     3  2     2  2  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  3  1  4  2  2  1  2  2  3  2  2  3  3  2  2  3  2     1  3  2  2  3  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|             
                                           | 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    UG/KG                                  | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Necrosis                             |                                                                         2|             
      Pigmentation                         |    1  2     1  2  2  1  2  2  2  1  1  1  2  2  1  1  2  1  1  2  2  1   |             
      Lymphoid Follicle, Atrophy           |                                                       2  2               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |    3  3  2  4  4     3     2              2  2  3     3  2  4  3        3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1           1  1  1     1  1  1  1     2  1  1  2  2  1        1  1  2  2|             
      Inflammation, Chronic Active         |                               3                                          |             
      Inflammation, Granulomatous          |       2                                                              2   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  1  2  1  2  1  1     2  1  2  4  1  2  1        1  1  1     2     2   |             
      Inflammation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         1  1  1        1                             1   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     2                                      3                           |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                     2           2                        |             
      Septum, Inflammation                 |                2                             3                       1   |             
      Turbinate, Inflammation              |       1        1                    2                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|             
                                           | 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    UG/KG                                  | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1  1              1           1  1        1           1  1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                        3                                 |             
      Calculus Micro Observation Only      |                                              X                           |             
      Casts Protein                        | 1                                                                        |             
      Degeneration                         |                                                                          |             
      Hydronephrosis                       |                                                                         3|             
      Infarct                              |                                                                3         |             
      Inflammation, Suppurative            |                   1           1                    1                     |             
      Mineralization                       | 1  1     1  1  1  1     1  1  1  1  1     1  1  1  1     1  1     1      |             
      Nephropathy                          |    1        1  1  1     1  1     1        1  1              1     1  1  1|             
      Pelvis, Inflammation                 |                               2                                3         |             
      Renal Tubule, Degeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                               2                                3         |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                         +|             
      Cyst                                 |                                                                         3|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      2        2                                3         |             
      Transitional Epithelium, Hyperplasia |                               2                                3         |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 0| 3|                                                                 |            |
                                           | 1| 1| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 0| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  1.0|
      Basophilic Focus                     |                                                                          |     16     |
      Basophilic Focus, Multiple           |    X  X                                                                  |      9     |
      Clear Cell Focus                     |       X                                                                  |      4     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   |    X                                                                     |      8     |
      Eosinophilic Focus, Multiple         | X                                                                        |      8     |
      Fatty Change, Diffuse                |                                                                          |      2  1.0|
      Fatty Change, Focal                  |                                                                          |      3  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |     13  1.1|
      Inflammation                         | 1  1  1                                                                  |     44  1.1|
      Mixed Cell Focus                     |                                                                          |      7     |
      Mixed Cell Focus, Multiple           | X     X                                                                  |     22     |
      Necrosis                             |    1                                                                     |      7  2.1|
      Pigmentation                         |    1                                                                     |      2  1.5|
      Bile Duct, Cyst                      |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 0| 3|                                                                 |            |
                                           | 1| 1| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 0| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Fibrosis                  | 2                                                                        |      2  1.5|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.0|
      Centrilobular, Degeneration          |                                                                          |      4  2.3|
      Hepatocyte, Hypertrophy              |                                                                          |      5  1.4|
      Serosa, Inflammation                 |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Inflammation, Chronic Active    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  16        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     16  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |    2                                                                     |      8  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  19        |
      Peridontal Tissue, Inflammation      |                                                                          |     19  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 0| 3|                                                                 |            |
                                           | 1| 1| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 0| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |       1                                                                  |     19  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1     2                                                                  |     34  1.8|
      Degeneration, Cystic                 |                                                                          |     15  2.3|
      Hyperplasia                          | 2                                                                        |     27  2.6|
      Hypertrophy                          | 1     2                                                                  |     45  1.8|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1     1                                                                  |     14  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          | 2  2  3                                                                  |     19  1.9|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 4  2                                                                     |     20  2.5|
      Cyst                                 |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |       3                                                                  |     22  2.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  | 1     1                                                                  |     23  2.0|
      Follicular Cell, Hypertrophy         |                                                                          |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 0| 3|                                                                 |            |
                                           | 1| 1| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 0| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +                                                                  |  52        |
      Inflammation                         |    1  2                                                                  |     41  1.8|
      Duct, Cyst                           |    2  4                                                                  |     36  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4                                                                     |     42  4.0|
      Cyst                                 |    3  3                                                                  |     17  2.2|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  +                                                                  |  44        |
      Cyst                                 |                                                                          |      2  3.0|
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |       3                                                                  |      5  2.4|
      Inflammation, Suppurative            | 2                                                                        |      6  1.8|
      Metaplasia, Squamous                 | 4  2  4                                                                  |     27  2.5|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     32  2.4|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 4  4                                                                     |     40  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 0| 3|                                                                 |            |
                                           | 1| 1| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 0| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Lumbar, Ectasia                      |                                                                          |      2  3.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Plasma Cell             | 2     2                                                                  |     30  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  3  2                                                                  |     52  2.2|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         | 1     2                                                                  |     47  1.6|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  52        |
      Atrophy                              | 3  3  2                                                                  |     37  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Hyperplasia                          | 1  1                                                                     |     32  1.2|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 0| 3|                                                                 |            |
                                           | 1| 1| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 0| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2  2  2                                                                  |     40  1.8|
      Inflammation                         |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     | 1  1  1                                                                  |     16  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      3  2.0|
      Goblet Cell, Hyperplasia             |                                                                          |      2  2.5|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.0|
      Septum, Inflammation                 |                                                                          |      5  1.8|
      Turbinate, Inflammation              |                                                                          |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Retina, Atrophy                      |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         | 1                                                                        |     13  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  3.0|
      Calculus Micro Observation Only      |                                                                          |      4     |
      Casts Protein                        |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 0| 3|                                                                 |            |
                                           | 1| 1| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 0| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Degeneration                         |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  1.0|
      Mineralization                       |       1                                                                  |     41  1.0|
      Nephropathy                          |    1                                                                     |     24  1.0|
      Pelvis, Inflammation                 |                                                                          |      2  2.5|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      6  1.7|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|             
                                           | 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
    UG/KG                                  | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Hemorrhage    |                                                                          |             
      Periesophageal Tissue, Inflammation  |                                                             2            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X              X  X                                X               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  1                                       |             
      Basophilic Focus                     |                         X              X           X                    X|             
      Basophilic Focus, Multiple           |       X                    X                          X        X         |             
      Eosinophilic Focus                   |                         X              X                 X     X         |             
      Eosinophilic Focus, Multiple         |                   X  X     X                    X     X           X  X   |             
      Fatty Change, Diffuse                | 1     1              1                                                   |             
      Fatty Change, Focal                  |                                                       2              1   |             
      Hematopoietic Cell Proliferation     |          1        1  1  2  1        3                    1     2  1  2   |             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1  1  1  3  1     1  1  1  1  2  1  1  1     1|             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           | X     X  X        X  X           X     X     X  X  X  X           X  X   |             
      Necrosis                             |                   2                 2                                    |             
      Pigmentation                         |                                           2                    2         |             
      Bile Duct, Cyst                      |                            2                 2                           |             
      Bile Duct, Fibrosis                  |       1                                                        1         |             
      Bile Duct, Hyperplasia               |       3              3  2                 1  1                 1        1|             
      Centrilobular, Degeneration          |                         1                                                |             
      Hepatocyte, Hypertrophy              | 1     1           1  1        2        2  1  1  1                    1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|             
                                           | 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
    UG/KG                                  | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Oval Cell, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                        +  +        +  +  +     +        +|             
      Gingival, Hyperplasia, Squamous      |                                        1           1  1  1     2        1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                           2                    2         |             
      Inflammation                         |             2                             2  2                           |             
      Mineralization                       |                                                                          |             
      Ulcer                                |             3                             3                              |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           2                              |             
      Inflammation                         |                                                                          |             
      Mineralization                       | 1     1     3                                                            |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +                 +  +  +     +        +  +  +  +     +        +|             
      Peridontal Tissue, Inflammation      | 1        1                 1  2  1     1        1  1  1  1     2        1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |             2                                                            |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             3     1  2     1        1  1           1  1        1  1     1|             
      Inflammation                         |                                                             2            |             
      Mineralization                       |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|             
                                           | 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
    UG/KG                                  | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     2  2     2     1     1  1        1     2  2  2  1  1               |             
      Atrophy                              |                                                                         2|             
      Degeneration, Cystic                 | 3                       1              3           2                     |             
      Hematopoietic Cell Proliferation     |                         1                                                |             
      Hyperplasia                          | 3              2  3  2  2              3  2  2  1  3     2  2            |             
      Hypertrophy                          | 2     2  2     2  2  2        1  2     2  2  2  3  2  2  3     2     2  2|             
      Inflammation                         |                                                             1            |             
      Mineralization                       |             1                                                     3      |             
      Necrosis                             |             3                                                  4         |             
      Vacuolization Cytoplasmic            |          2        2  2  2  2              2     1        1  1            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |             1                          4     4  2  2  3     2  2        3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3     1  2        2        2  1     2  2  3                 3  2     2|             
      Atypia Cellular                      |                                                                          |             
      Pars Distalis, Hyperplasia           |          3     1                 2     2  3     2     3           2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2     1        1           1     2              1           1      |             
      Follicular Cell, Hypertrophy         |                1                                      2                 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|             
                                           | 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
    UG/KG                                  | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation                         | 1  1  1  2  2  2  2  2  3     3  2  1  1  2  1  1  2  1  2  1     1  1  1|             
      Duct, Cyst                           | 1     1  2  2  3  4  3     2  2  3  1  2  3  1  1  3     2  2  1        2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4     4     4     4  4  4  4  4     4  4  3        4|             
      Cyst                                 |       3  2     3           2        2  2        3  2              3      |             
      Inflammation, Chronic Active         |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  +  +  +  +  +  +  +  M  M  M  M  M  M  M  M  +  +  +  M  +  M  M|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                 3                        |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Inflammation, Suppurative            |          1                                                               |             
      Metaplasia, Squamous                 |    4     3     2                 1        2     2  2     4        4      |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2        3  3  2  3  2     3     2     3  2  3  2  1           2        2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  4     3  4  3  3  3  4  4        4  2  3     4  2     3  3     4  4   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                   +      |             
      Renal, Inflammation, Chronic Active  |                                                                   4      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |    2  3  2              2  2  4     2  2     3  2  3  3  2  3  3  2     2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|             
                                           | 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
    UG/KG                                  | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  1  2  3  1  2  2  3  3     1  4  1     1  1  1  2  3  1  4  3  3  1|             
      Pigmentation                         | 2  1  1  1  1  1  1  1  1  1  2  2     1  3  1  1  2  1  1  2     1  1  1|             
      Lymphoid Follicle, Atrophy           |                               2           4                 2            |             
      Red Pulp, Atrophy                    |                               2           3                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  2  2  3  2  3     2  3     2     3  4  2  4  2     2  3     3  4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2                                 |             
      Hyperplasia                          | 1  1  1        1        1     2        2     1  1  1  2           1  1   |             
      Inflammation, Granulomatous          |                   2                    2           1                     |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                               2                                          |             
      Hyperplasia, Histiocytic             |          3                                                               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  1  2     2  2  1     1  1  2  2  1  1     2  3  1        2  2  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|             
                                           | 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
    UG/KG                                  | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Inflammation                         |                                              2              4            |             
      Metaplasia, Squamous                 |       1                                                                  |             
      Mineralization                       |             3                                                            |             
      Alveolar Epithelium, Hyperplasia     |       1  1        1  1                             2  2        1         |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                             3            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2                 1           1                       3            |             
      Goblet Cell, Hyperplasia             |       2                                                                  |             
      Septum, Inflammation                 |    1                                1                       1            |             
      Turbinate, Inflammation              |    1  2     2     1  2  1           1                       2            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Degeneration                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  1  1  1  1                                      1           1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                      X                                                   |             
      Casts Protein                        |                2                                                         |             
      Cyst                                 |    2                                                                     |             
      Infarct                              |                                                                   2      |             
      Inflammation, Suppurative            |                                                                   1      |             
      Mineralization                       |    1  1  1  2     1  1  1        1  1  1  1     1  1     1  1     1  1  1|             
      Nephropathy                          | 1  1  1  1           1        1  1     2     1  1  1  1  1     1  2     1|             
      Pelvis, Inflammation                 |                            2                                   2        2|             
      Transitional Epithelium, Hyperplasia |                            2                                   1         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3                          2                          1        2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|             
                                           | 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
    UG/KG                                  | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                            2                                   1         |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|             
                                           | 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    UG/KG                                  | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                2         |             
      Periesophageal Tissue, Hemorrhage    |          3                                                               |             
      Periesophageal Tissue, Inflammation  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                           X  X         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                               X                                          |             
      Basophilic Focus, Multiple           |       X        X                                   X                     |             
      Eosinophilic Focus                   |    X                       X                       X                     |             
      Eosinophilic Focus, Multiple         |       X     X        X                                   X               |             
      Fatty Change, Diffuse                |                1                 1  1           1        1        1     1|             
      Fatty Change, Focal                  |    1        1                                                        1   |             
      Hematopoietic Cell Proliferation     |             2  1        1  1  1        1           1  1                  |             
      Inflammation                         | 1  1  1  1  1     2  1  1  1  1  1  1     1     1  1  2  1  1     1  1  1|             
      Mixed Cell Focus                     |    X                                                     X  X  X     X   |             
      Mixed Cell Focus, Multiple           | X     X              X     X              X     X                        |             
      Necrosis                             |                         1                          1  2                  |             
      Pigmentation                         | 1     2           1                                                      |             
      Bile Duct, Cyst                      |                            2                                             |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1                       2                    1           1        2   |             
      Centrilobular, Degeneration          |                                                       3                  |             
      Hepatocyte, Hypertrophy              | 2  1  2              1           2  2           2        1  1     1  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|             
                                           | 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    UG/KG                                  | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Oval Cell, Hyperplasia               |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |             +        +                          +  +              +      |             
      Gingival, Hyperplasia, Squamous      |             1        1                          1  1              1      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
      Acinus, Atrophy                      |                                           2                              |             
      Acinus, Vacuolization Cytoplasmic    |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |    2                                            1                    2  1|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                    1  2                  |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                    2                     |             
      Inflammation                         |                      2                             2                     |             
      Mineralization                       |       1     1        1                          1              2  2      |             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +     +        +                 +        +  +  +     +     +      |             
      Peridontal Tissue, Inflammation      |       1     2        1                 1        1  2  1           1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           1     1  1  1  1                          1           1      |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|             
                                           | 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    UG/KG                                  | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1  2              2           1  2     2     2        2        1  2   |             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |       3                    3     1  3     2  2  3     1              2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       3     2              3        3     2  3  3        3  2  2  4  3   |             
      Hypertrophy                          | 2     2     2  1     2     2     1  2     2        2     2     1  2  2  1|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                               2     2        1        2  3  1     2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |             3                    2           1  1              2         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1                                             |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     4     2        2     2     2  2        2  3        2  2        1  3|             
      Atypia Cellular                      |                                                    2                     |             
      Pars Distalis, Hyperplasia           |    1                 4     3  2              2                 2  2  4   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     2     2                    1  2     2              2           2  2|             
      Follicular Cell, Hypertrophy         |    2                 2     1        2     2                    1  2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|             
                                           | 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    UG/KG                                  | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
      Inflammation                         | 3  3  2  2  3  2  3  2     1  1  1  1     2  1  2  1  1  1  1  1  2  1  2|             
      Duct, Cyst                           | 2  4  2  2  4  1  3  2  3  1  3  2        2     4  2  3  3  3  3  3  4  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4     4     4  4  4  4     4  4        4  4  4     4  4  4  4  4  4|             
      Cyst                                 |    1                             2        2        2     2        2      |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           2                              |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                   2      |             
      Congestion                           |       1                                                                  |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                   2        3                                             |             
      Inflammation, Suppurative            | 1                                                                        |             
      Metaplasia, Squamous                 |    2                       1                       3           2  1  2  1|             
      Thrombosis                           |                            3                                             |             
      Endometrium, Hyperplasia, Cystic     | 3     2           4  3           1  2        1  2        3  2  2  3  2   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        3  4  3  3     3  4  4     3  4        2  3  4  2  2  2  3  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                              +                           |             
      Renal, Inflammation, Chronic Active  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Hyperplasia, Plasma Cell             | 3  2  2  3  3     2  2     2     2  2           3        2  2        2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|             
                                           | 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    UG/KG                                  | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1     3  2  1  1  3  3  4  1  2  2  2     1  2  3  1  2  1  2  2   |             
      Pigmentation                         | 2  2  2  2  1  1  1  1  1     1  2  1  1  1     2  1  1  1  2  1  2  2  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3              2     2  3  2  4  2  2     3     2  3     2        2  2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                                                        |             
      Hyperplasia                          | 2        1     1     1              2     3     1     3  1  3     1      |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              2                           |             
      Hydrocephalus                        |                                                          2               |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Mineralization                       |                                                                   2      |             
      Necrosis                             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  1     1  1     1     2     1  2     2     1  1  1  1  1  1  1  1  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|             
                                           | 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    UG/KG                                  | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Inflammation                         |    1                 2                    2              2               |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1                       1        1     1                              |             
      Mediastinum, Hemorrhage              |          3                                                               |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1                                                   |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Septum, Inflammation                 |                                                                          |             
      Turbinate, Inflammation              |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Degeneration                   |                                                                1         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1           1        2     1              1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         X  X                 X           X               |             
      Casts Protein                        |                                                                          |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                   3      |             
      Inflammation, Suppurative            |                                                             1            |             
      Mineralization                       | 1  1  1     1     1  1  1     1  1  1     1     1  1  1  2  1  1     1  1|             
      Nephropathy                          | 1  1  1     1        1        1  2  1     1     1     1     1     2  1  1|             
      Pelvis, Inflammation                 |                                                                   3      |             
      Transitional Epithelium, Hyperplasia |       2                                                           3      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               2              2  1                 3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|             
                                           | 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    UG/KG                                  | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                   3      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 6|                                                                 |            |
                             DAY ON TEST   | 3| 6| 2|                                                                 |            |
                                           | 1| 9| 4|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
      Periesophageal Tissue, Hemorrhage    |                                                                          |      1  3.0|
      Periesophageal Tissue, Inflammation  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      7     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     | X                                                                        |      6     |
      Basophilic Focus, Multiple           |                                                                          |      7     |
      Eosinophilic Focus                   |                                                                          |      7     |
      Eosinophilic Focus, Multiple         |       X                                                                  |     12     |
      Fatty Change, Diffuse                | 1                                                                        |     11  1.0|
      Fatty Change, Focal                  |                                                                          |      5  1.2|
      Hematopoietic Cell Proliferation     |                                                                          |     18  1.3|
      Inflammation                         | 1  1  1                                                                  |     47  1.1|
      Mixed Cell Focus                     |       X                                                                  |      6     |
      Mixed Cell Focus, Multiple           |                                                                          |     19     |
      Necrosis                             |                                                                          |      5  1.6|
      Pigmentation                         |                                                                          |      5  1.6|
      Bile Duct, Cyst                      |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 6|                                                                 |            |
                             DAY ON TEST   | 3| 6| 2|                                                                 |            |
                                           | 1| 9| 4|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Fibrosis                  |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               | 2                                                                        |     14  1.6|
      Centrilobular, Degeneration          |                                                                          |      2  2.0|
      Hepatocyte, Hypertrophy              | 2                                                                        |     24  1.4|
      Oval Cell, Hyperplasia               |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  12        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     11  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
      Ectopic Tissue                       |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      6  1.7|
      Inflammation                         |                                                                          |      3  2.0|
      Mineralization                       |                                                                          |      2  1.5|
      Ulcer                                |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      2  2.0|
      Inflammation                         |                                                                          |      2  2.0|
      Mineralization                       |       2                                                                  |     10  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |  22        |
      Peridontal Tissue, Inflammation      |       2                                                                  |     21  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 6|                                                                 |            |
                             DAY ON TEST   | 3| 6| 2|                                                                 |            |
                                           | 1| 9| 4|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |                                                                          |     19  1.2|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 2                                                                        |     25  1.6|
      Atrophy                              |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |     13  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          | 2  1  2                                                                  |     27  2.4|
      Hypertrophy                          | 3     2                                                                  |     35  1.9|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  3.5|
      Vacuolization Cytoplasmic            |                                                                          |     16  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 2                                                                        |      1  2.0|
      Hyperplasia                          |                                                                          |     14  2.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |       3                                                                  |     26  2.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 6|                                                                 |            |
                             DAY ON TEST   | 3| 6| 2|                                                                 |            |
                                           | 1| 9| 4|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Atypia Cellular                      |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     16  2.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |       2                                                                  |     17  1.6|
      Follicular Cell, Hypertrophy         |       2                                                                  |     12  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation                         | 1  1                                                                     |     48  1.6|
      Duct, Cyst                           | 3                                                                        |     43  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |     38  4.0|
      Cyst                                 | 2     2                                                                  |     17  2.2|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  M                                                                     |  35        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |       3                                                                  |      4  2.8|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Metaplasia, Squamous                 |       3                                                                  |     17  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 6|                                                                 |            |
                             DAY ON TEST   | 3| 6| 2|                                                                 |            |
                                           | 1| 9| 4|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Thrombosis                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     28  2.3|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          |    3  2                                                                  |     38  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Renal, Inflammation, Chronic Active  |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M                                                                  |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 3  3                                                                     |     33  2.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     48  1.9|
      Pigmentation                         | 2  1  1                                                                  |     49  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      3  2.7|
      Red Pulp, Atrophy                    |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
      Atrophy                              | 3     2                                                                  |     35  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      2  2.5|
      Hyperplasia                          | 2  1  1                                                                  |     27  1.4|
      Inflammation, Granulomatous          |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 6|                                                                 |            |
                             DAY ON TEST   | 3| 6| 2|                                                                 |            |
                                           | 1| 9| 4|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      2  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 1     2                                                                  |     40  1.4|
      Inflammation                         |                                                                          |      6  2.2|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     11  1.2|
      Mediastinum, Hemorrhage              |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |       1                                                                  |      6  1.5|
      Goblet Cell, Hyperplasia             |                                                                          |      1  2.0|
      Septum, Inflammation                 |                                                                          |      3  1.0|
      Turbinate, Inflammation              |                                                                          |      9  1.4|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 6|                                                                 |            |
                             DAY ON TEST   | 3| 6| 2|                                                                 |            |
                                           | 1| 9| 4|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Lens, Degeneration                   |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         | 1  1                                                                     |     16  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      | X     X                                                                  |      7     |
      Casts Protein                        |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mineralization                       | 1  1                                                                     |     39  1.1|
      Nephropathy                          | 1     1                                                                  |     33  1.1|
      Pelvis, Inflammation                 |                                                                          |      4  2.3|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      8  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|             
                             DAY ON TEST   | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|             
                                           | 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    UG/KG                                  | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                         1                                                |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                       X  X      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1        2        2           2              2                       3|             
      Basophilic Focus                     |                   X                                                      |             
      Basophilic Focus, Multiple           |          X                                X           X                  |             
      Cholangiofibrosis                    |                   2                                                      |             
      Eosinophilic Focus                   | X  X              X           X        X     X        X     X        X   |             
      Eosinophilic Focus, Multiple         |          X              X  X                    X                       X|             
      Fatty Change, Diffuse                | 1  1  2                 1  1     1     1     1     3  1           1      |             
      Fatty Change, Focal                  |          1           1                                                   |             
      Hematopoietic Cell Proliferation     |    1        1     1     1           1  1           1                 1   |             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Hyperplasia, Nodular                 |                      X                                                   |             
      Inflammation                         | 2  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1     1  1  1  1  1|             
      Mixed Cell Focus                     |             X           X                 X                              |             
      Mixed Cell Focus, Multiple           | X  X  X                          X     X              X           X     X|             
      Necrosis                             |                            3              1              3           1   |             
      Pigmentation                         | 1              1                 1                                       |             
      Bile Duct, Cyst                      |                                        2        4     2                  |             
      Bile Duct, Fibrosis                  |                                                                         1|             
      Bile Duct, Hyperplasia               | 2                    2        1           2                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|             
                             DAY ON TEST   | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|             
                                           | 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    UG/KG                                  | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
      Hepatocyte, Hypertrophy              | 2  1  2  2  1  3  1  2  1     2  2     2  3  2  3  3        2  2  2     3|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +                             +        +  +                 +            |             
      Gingival, Hyperplasia, Squamous      | 1                             2        1  1                 2            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                      2                             2                     |             
      Inflammation                         |                                                             2            |             
      Mineralization                       |                                                    2                     |             
      Ulcer                                |                                                             2            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          1                                2     1                    2   |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +                       +        +  +  +           +  +     +      |             
      Peridontal Tissue, Inflammation      | 1     1                       2        2  1  1           1  3     1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1        1  1  1                 1  1  1  1  2  1        1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     2  1  2  2        2  2  1  2           2  2     2     2  2        1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|             
                             DAY ON TEST   | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|             
                                           | 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    UG/KG                                  | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Atrophy                              |                2                                                         |             
      Degeneration, Cystic                 |       1     2  3        2        2        1                 2           2|             
      Hyperplasia                          |       2  3  3  3  2  3  2     2  2     2              2  2  2        2  3|             
      Hypertrophy                          | 2     2  2  1  2  2  1  2  2  2  2        3  2  2  2  2     1  2  1  2  2|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                       2  3               |             
      Vacuolization Cytoplasmic            |       1              1     1  1              1  2     2                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  2  2     1     3     2     2           2  1     1  2                  |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     1     1  3     3           3        3     3     2  2  3  2        3|             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |          3  2     1     3  2                 2     1  3  2     3  2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      C-Cell, Hyperplasia                  | 2  1           2     2        2  2                    2        2     2  2|             
      Follicular Cell, Hyperplasia         |       2              2                                                   |             
      Follicular Cell, Hypertrophy         |                      4        2     2  2     2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  2  1  1  1  2  2  1  1     2  2  2  2  1  2  1  2  1  2  1  1  1  2|             
      Duct, Cyst                           | 4  3           2  3  3  2  3     1  2  1  3     3     4  2  3  2  2  1   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4     4  4  4  4  4  4     3  4     4  4  4  4  4  4  4  4  4  4     4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|             
                             DAY ON TEST   | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|             
                                           | 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    UG/KG                                  | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 | 2              3                          2  2  2  2              3  2   |             
      Inflammation, Chronic Active         |                                                             3           4|             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3                           |             
      Inflammation, Chronic Active         |                                              2              4           4|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                   3      |             
      Inflammation, Suppurative            | 2  2           2  1  3                 3        3                       2|             
      Metaplasia, Squamous                 | 1  3     2  1  3  4  3        3  2     4        3           3  2  4     3|             
      Thrombosis                           |                                                                          |             
      Cervix, Hyperplasia, Stromal         | 3                                      3                                 |             
      Endometrium, Hyperplasia, Cystic     |    1  2  2  2           3     3  2        2  3  2  3  3        1     1   |             
      Endometrium, Hyperplasia, Stromal    | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  4  2  4  4  3  4  4  3     3     4  3  2        4  3     4  2  3  4  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
      Iliac, Ectasia                       |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                | 2     3              2                                                   |             
      Hyperplasia, Plasma Cell             | 2  3  2  2  3  3     2        2  2  2  3  3  2  3  3  2     3  3  2     3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|             
                             DAY ON TEST   | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|             
                                           | 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    UG/KG                                  | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  3  2  2  3     3  1  2  1  2  1  2  2  1  2     3           1  1  2  1|             
      Pigmentation                         | 2  1  1  1  1  2  1  2  1  1  1  2  1  1  2  1  2  1  2     3  2  1  1  2|             
      Lymphoid Follicle, Atrophy           |                            2                                2            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  4     2  3  4  2  2  4     2           2  2  2  3  3  4  2  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1     2  1     1     1  1  2     2        2     2  1  1     1  1     2   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1           1  1        2  2                 2  1        2  2  1   |             
      Inflammation                         |                2                                                         |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                             1  1                             1         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|             
                             DAY ON TEST   | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|             
                                           | 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    UG/KG                                  | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1                                         2         |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 2                                                                        |             
      Septum, Inflammation                 |                   1  1                                         1         |             
      Turbinate, Inflammation              | 2           2  2     2              2                          1         |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Exudate            |                                                                          |             
      Retina, Atrophy                      |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               2     1        1  1                       1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    1  1  1  1  1  1     1  2  1  1           1        1  1  1  1  1  1  1|             
      Nephropathy                          | 1     1  1  1  1  1  1     1     1  1     1  1  2     1           1     1|             
      Pelvis, Inflammation                 |    1                          2                 2                        |             
      Transitional Epithelium, Hyperplasia |                               1                 2                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                                            1                 1  1   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|             
                                           | 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    UG/KG                                  | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X           X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  1                 2                     |             
      Basophilic Focus                     |                                  X                                   X   |             
      Basophilic Focus, Multiple           |                         X                                   X     X     X|             
      Cholangiofibrosis                    |                                                                          |             
      Eosinophilic Focus                   |                               X                    X              X      |             
      Eosinophilic Focus, Multiple         | X                       X                       X                    X   |             
      Fatty Change, Diffuse                | 1  1  2     1                    2  1        1     1                    2|             
      Fatty Change, Focal                  |                                        1                 1               |             
      Hematopoietic Cell Proliferation     |    1  1                 1        1  1     1     1                        |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation                         | 1  1  1     1        1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |    X                                   X                                 |             
      Mixed Cell Focus, Multiple           | X           X           X     X              X  X  X  X  X     X     X   |             
      Necrosis                             |       2  2     2           2              3                       1     2|             
      Pigmentation                         |                2     1                                                   |             
      Bile Duct, Cyst                      |    3                                                           2         |             
      Bile Duct, Fibrosis                  |                                              1                           |             
      Bile Duct, Hyperplasia               |                                     1        3           2  1  1  1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|             
                                           | 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    UG/KG                                  | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Centrilobular, Degeneration          |                2                                                         |             
      Hepatocyte, Hypertrophy              | 2  3        1     3  3  2     2  2     3     1  1  1  2  3  2  3     1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +  +        +  +  +     +                 +  +  +        +      |             
      Gingival, Hyperplasia, Squamous      |          2  2        2  1  1     1                 1  2  1        1      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Vacuolization Cytoplasmic    |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                            2                                             |             
      Hyperplasia, Squamous                |                      1     2                                             |             
      Inflammation                         |                            2                                             |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                            2                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2        1        1                                               1  2|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +  +  +     +  +        +  +           +  +  +  +        +      |             
      Peridontal Tissue, Inflammation      |    1     1  2  1     1  3        1  3           1  1  1  1        1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                         2|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           1  1     1     1     1           2     1        1           1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2        1     1     1     2  1              1  1     2  2  2     2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|             
                                           | 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    UG/KG                                  | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Atrophy                              | 2                                                                        |             
      Degeneration, Cystic                 | 3           2                                   1              3         |             
      Hyperplasia                          | 4  3     2  2        2     3           2     2  3  2  3     2  3         |             
      Hypertrophy                          | 1  3  2     2     3  2  2  2  2  2  1  2  2  2     1  2  2     2  2  3   |             
      Mineralization                       |                                                                         2|             
      Necrosis                             |                                                                         3|             
      Vacuolization Cytoplasmic            |       2  3        2                                1  1                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3        2        2  2              1        2  4           3     3   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  3        2     4  2     3     2     2        1     1     3  2     2   |             
      Cytoplasmic Alteration               |             2                                                            |             
      Vacuolization Cytoplasmic            |                               1                                          |             
      Pars Distalis, Hyperplasia           |             2  2        3     3     1  3     3  3  2  3        2     3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      C-Cell, Hyperplasia                  | 2           1        2        2  3     1                       2     2   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         | 2           2     2                                               2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation                         | 3  2  2  1  1        1  2  1  2  2  2  2  1  2  1  1  2  1     2  1  1   |             
      Duct, Cyst                           | 1  3  2  2  2  3  3  1  2  1  2  2  3  2  3  3  3  1  3  1     3  2  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4     4     4     3  4  4  4  4  4     3  4   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|             
                                           | 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    UG/KG                                  | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |                   2  2  2  2  3              3              2  2         |             
      Inflammation, Chronic Active         |             3     3                    2                                 |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  +  +        +  +  M  M  +  +  +  +  M  +  M  +  +  M  M  +  +  M|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |             3                                                        3   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3                                       |             
      Inflammation, Chronic Active         |                                                                   3      |             
      Inflammation, Suppurative            |    2  2  2  1  2        1     2        2                                 |             
      Metaplasia, Squamous                 |    4     3  4           3     4        3        2  3  1              2   |             
      Thrombosis                           |                         3        3                                       |             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3     2              2  3        3     3        2  3  1              1   |             
      Endometrium, Hyperplasia, Stromal    |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2  4  4  3  4     4  4  4  2  3     3  3     4  2        3     3  2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +     +              +              +               |             
      Iliac, Ectasia                       |                      2                                                   |             
      Iliac, Hyperplasia, Plasma Cell      |                      3                                                   |             
      Lumbar, Hyperplasia, Histiocytic     |                                           2                              |             
      Lumbar, Hyperplasia, Plasma Cell     |                                           3                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
      Ectasia                              |                                                       2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 3  2  2  2           2     2     2  2  2     3  2  2     2  2  3  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|             
                                           | 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    UG/KG                                  | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  1  4     1  1     3  2  2  2  2  2  2  2  2  2  1  2  1  1  1  2  1  3|             
      Pigmentation                         | 1  2  1  1  1  1  3  1     1  2  1  2  2     2  1  2  1  2  2  1  1  2  1|             
      Lymphoid Follicle, Atrophy           |                                                             2            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  3  3  2     3  3  3  3  2  3  2  2  3  2        2        2     2  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                                                      |             
      Hyperplasia                          | 1  1     1  2     1        1     1  2        2     1     1  1  2  1     1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                               |             
      Hydrocephalus                        |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             2            |             
      Infiltration Cellular, Histiocyte    |          2  2     1     2     1  1        1  1     2  1  2     1  1  1   |             
      Inflammation                         |          3        1                             2                       2|             
      Metaplasia, Squamous                 |                                                    2                     |             
      Mineralization                       |                                                                         3|             
      Alveolar Epithelium, Hyperplasia     |             1           2                          1  1  1               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|             
                             DAY ON TEST   | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|             
                                           | 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    UG/KG                                  | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                          3                             2               |             
      Goblet Cell, Hyperplasia             | 2                                                        2               |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Septum, Inflammation                 | 2                                               2        1               |             
      Turbinate, Inflammation              | 2        1                                               2               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Exudate            |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1  1     1  1        1  2        1        1  1  1        1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      | X                                      X              X     X            |             
      Hydronephrosis                       |                            3                                             |             
      Inflammation, Chronic Active         |                            2                             1               |             
      Inflammation, Suppurative            |                         1                    1                           |             
      Mineralization                       | 1  1  1  2  1  1  1        1  1     1  1  1     1     1  1  1  1  1  1  3|             
      Nephropathy                          | 1     3     1        1  1        1     1     2     1        1        1   |             
      Pelvis, Inflammation                 |                      2                             2                     |             
      Transitional Epithelium, Hyperplasia |          2           2                             2        2            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      2           1  1           1  2  1  1              1|             
      Transitional Epithelium, Hyperplasia |          2           2                                                   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5|                                                                 |            |
                             DAY ON TEST   | 3| 8| 7|                                                                 |            |
                                           | 6| 3| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    1000                                   | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 3| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |       3                                                                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      5     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      8  1.9|
      Basophilic Focus                     |                                                                          |      3     |
      Basophilic Focus, Multiple           |                                                                          |      7     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Eosinophilic Focus                   | X     X                                                                  |     14     |
      Eosinophilic Focus, Multiple         |                                                                          |      9     |
      Fatty Change, Diffuse                | 1                                                                        |     21  1.3|
      Fatty Change, Focal                  |                                                                          |      4  1.0|
      Hematopoietic Cell Proliferation     |    1                                                                     |     16  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Nodular                 |                                                                          |      1     |
      Inflammation                         | 1  2                                                                     |     48  1.1|
      Mixed Cell Focus                     |                                                                          |      5     |
      Mixed Cell Focus, Multiple           |                                                                          |     19     |
      Necrosis                             |    3                                                                     |     12  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5|                                                                 |            |
                             DAY ON TEST   | 3| 8| 7|                                                                 |            |
                                           | 6| 3| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    1000                                   | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 3| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         |                                                                          |      5  1.2|
      Bile Duct, Cyst                      |                                                                          |      5  2.6|
      Bile Duct, Fibrosis                  |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               |                                                                          |     10  1.6|
      Centrilobular, Degeneration          |    2                                                                     |      2  2.0|
      Hepatocyte, Hypertrophy              | 1     2                                                                  |     39  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |  16        |
      Gingival, Hyperplasia, Squamous      |    1                                                                     |     16  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      4  1.8|
      Inflammation                         |       1                                                                  |      3  1.7|
      Mineralization                       | 2                                                                        |      2  2.0|
      Ulcer                                |       2                                                                  |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       | 2                                                                        |     10  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |  23        |
      Peridontal Tissue, Inflammation      |    1                                                                     |     23  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5|                                                                 |            |
                             DAY ON TEST   | 3| 8| 7|                                                                 |            |
                                           | 6| 3| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    1000                                   | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 3| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1     1                                                                  |     23  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1                                                                        |     29  1.6|
      Atrophy                              |                                                                          |      2  2.0|
      Degeneration, Cystic                 |                                                                          |     12  2.0|
      Hyperplasia                          |                                                                          |     28  2.4|
      Hypertrophy                          | 1                                                                        |     42  1.9|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      3  2.7|
      Vacuolization Cytoplasmic            |                                                                          |     12  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |     20  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +                                                                  |  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 3     3                                                                  |     28  2.4|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     23  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |       2                                                                  |     19  1.9|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
      Follicular Cell, Hypertrophy         |                                                                          |     10  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5|                                                                 |            |
                             DAY ON TEST   | 3| 8| 7|                                                                 |            |
                                           | 6| 3| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    1000                                   | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 3| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  51        |
      Inflammation                         | 3  2  2                                                                  |     48  1.6|
      Duct, Cyst                           | 2  3  3                                                                  |     45  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     44  3.9|
      Cyst                                 |                                                                          |     16  2.3|
      Inflammation, Chronic Active         |                                                                          |      5  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  M  +                                                                  |  39        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      5  3.2|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |     16  2.0|
      Metaplasia, Squamous                 | 2     1                                                                  |     27  2.7|
      Thrombosis                           |                                                                          |      2  3.0|
      Cervix, Hyperplasia, Stromal         |                                                                          |      2  3.0|
      Endometrium, Hyperplasia, Cystic     | 2                                                                        |     25  2.2|
      Endometrium, Hyperplasia, Stromal    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2  4  3                                                                  |     42  3.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Iliac, Ectasia                       |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5|                                                                 |            |
                             DAY ON TEST   | 3| 8| 7|                                                                 |            |
                                           | 6| 3| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    1000                                   | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 3| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             | 2                                                                        |     37  2.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 1  3  1                                                                  |     46  1.8|
      Pigmentation                         | 2     2                                                                  |     49  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
      Atrophy                              |    3  3                                                                  |     41  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          | 1     1                                                                  |     32  1.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            | X                                                                        |      1     |
      Inflammation                         | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5|                                                                 |            |
                             DAY ON TEST   | 3| 8| 7|                                                                 |            |
                                           | 6| 3| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    1000                                   | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 3| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           | 3                                                                        |      2  3.0|
      Hydrocephalus                        |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |    1  1                                                                  |     27  1.4|
      Inflammation                         | 1     1                                                                  |      7  1.7|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      9  1.1|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |       1                                                                  |      6  1.8|
      Goblet Cell, Hyperplasia             |                                                                          |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Septum, Inflammation                 |       2                                                                  |      7  1.4|
      Turbinate, Inflammation              |       1                                                                  |     10  1.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Anterior Chamber, Exudate            | 2                                                                        |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     16  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5|                                                                 |            |
                             DAY ON TEST   | 3| 8| 7|                                                                 |            |
                                           | 6| 3| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    1000                                   | 9| 9| 9|                                                                 |      L     |
    UG/KG                                  | 3| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |    X                                                                     |      5     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mineralization                       |    1  1                                                                  |     40  1.1|
      Nephropathy                          | 3                                                                        |     28  1.2|
      Pelvis, Inflammation                 |                                                                          |      5  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |    1                                                                     |     13  1.2|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|             
                             DAY ON TEST   | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|             
                                           | 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                         X|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Basophilic Focus                     |          X     X                                      X                  |             
      Basophilic Focus, Multiple           |                                              X                           |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |    X        X           X                                   X  X        X|             
      Eosinophilic Focus, Multiple         |          X        X                             X  X  X                  |             
      Fatty Change, Diffuse                |                1        1        1     1  1  2  1  2  1              1   |             
      Fatty Change, Focal                  |          1                                                               |             
      Hematopoietic Cell Proliferation     |    1  1     1     1     1     1     1  1                                 |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Inflammation                         | 1  1     2     2  2  1  1  1  1  2  1  1  1  1  1  1  1  1  2  2  1  1   |             
      Mixed Cell Focus                     |                X                          X                              |             
      Mixed Cell Focus, Multiple           |          X                                   X  X  X  X           X  X   |             
      Necrosis                             |                      2              2  3     3           1  3           3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|             
                             DAY ON TEST   | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|             
                                           | 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         |                      1                    1     1                        |             
      Bile Duct, Cyst                      |          3                                      2                        |             
      Bile Duct, Fibrosis                  |                1                                                         |             
      Bile Duct, Hyperplasia               | 3        1     2        1        1        1  2  2     2                  |             
      Centrilobular, Degeneration          |             2                 2     3                                    |             
      Hepatocyte, Hypertrophy              | 3  1  2  1        2  2  2  2     2     2  3  3  3  3  3  3  3  1  1  3  1|             
      Oval Cell, Hyperplasia               | 1                                               1                        |             
      Serosa, Fibrosis                     |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +  +     +  +  +  +  +     +        +     +     +  +        +  +   |             
      Gingival, Hyperplasia, Squamous      |       1  1     1  1  2  1  1     1        1     1     1  1        1  1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                     1  2                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                      2                                                   |             
      Hyperplasia, Squamous                |                      3                                   2               |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1                                                                        |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +  +  +  +  +  +  +     +        +     +  +  +  +  +     +  +   |             
      Peridontal Tissue, Inflammation      | 1        1  1  1  1  2  1  1     1        1     1  1  1  1  2     2  2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        1     1     1     1     1        1           1     1        2   |             
      Inflammation                         |                         1                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|             
                             DAY ON TEST   | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|             
                                           | 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2                             1        2           2              1   |             
      Degeneration, Cystic                 | 2        2              2  2                       1     2           1   |             
      Hematopoietic Cell Proliferation     |                                        1                                 |             
      Hyperplasia                          |                            3                    2     4        2         |             
      Hypertrophy                          | 4  1     4        1     2  3     1     1  2  2  3  3  3  3  1  1     3  1|             
      Inflammation                         |                                                                          |             
      Necrosis                             |                3                                                         |             
      Vacuolization Cytoplasmic            |          1                          2        1  2                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                         1                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          | 3        2     2     3                          2                        |             
      Cyst                                 |                2                                                         |             
      Pars Distalis, Hyperplasia           |                   3        2     1     3           3  1  1  2  1     4   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                  2              2                 2  2  1|             
      Follicular Cell, Hyperplasia         | 2              1                                                         |             
      Follicular Cell, Hypertrophy         | 2  2        2              2                          1  1        2     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         | 1  2     1  1  2  1  1  2  2  1  1  1  2  1  1  2  2  1  1     1  1  2   |             
      Duct, Cyst                           | 2        1  1  3  1  2  1  3  2     2  2  2  3  3     3  1  2     3  3  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|             
                             DAY ON TEST   | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|             
                                           | 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4     4  4  4  4  4  4  4     4     4  4  4  4  4     4  4  4  4  4  4|             
      Cyst                                 | 2        2  2        2                          3     1  2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Dilatation                           |                                                 4                        |             
      Inflammation, Chronic Active         |          2     2                                                         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |          4     3                       2  3                              |             
      Inflammation, Suppurative            |                                                    1        2  2     2  1|             
      Metaplasia, Squamous                 | 4  2     4     4  2  1  2  2     3     4  1     4  3     2     2     3  2|             
      Endometrium, Hyperplasia, Cystic     |    2              2     2  2     2                 2     2  3  2     3   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3  4  3  2  2  3  2  2  2  3  2  3  4  2  2     3     3  3  4  3  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +        +                 +                                    |             
      Lumbar, Ectasia                      |                                     3                                    |             
      Lumbar, Hemorrhage                   |                                     2                                    |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Ectasia                 |                   3                                                      |             
      Renal, Ectasia                       |          4                                                               |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                       3                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 3  2     2     2  2  3  2        2  2  2        2  2  2  2  2  2  3  2   |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|             
                             DAY ON TEST   | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|             
                                           | 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  2  1  3  1  2     1  1  3  1  3  3  1  2  1  1  1  1  1  1     1  1|             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                             3            |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  1  1  1     2  1  2  1  1     1     1  2  1  2  1  1  1  3  1  2  1  1|             
      Lymphoid Follicle, Atrophy           |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  2  3     3     2        2     3  3  2        3     2  3        3  2|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                2                                       |             
      Hyperplasia                          | 2        1           1                 1  1  1  1     2              1   |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|             
                             DAY ON TEST   | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|             
                                           | 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2        1        1     1  1     1              2     1  1        1  1   |             
      Inflammation                         |                                                    1        2  1         |             
      Metaplasia, Squamous                 |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                 1      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Nasolacrimal Duct, Inflammation      |          3                                                               |             
      Septum, Inflammation                 |                                                                         1|             
      Turbinate, Inflammation              |                                                 1        1        1  1  2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1                                         1     1           1  1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                   1                                                      |             
      Calculus Micro Observation Only      |    X                                                                     |             
      Casts Protein                        |                                                                          |             
      Inflammation, Chronic Active         |                               1                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    1  1  1  1  1  1  1  1  1  2  1     1  1  1  1  1     1     1  1  1  1|             
      Nephropathy                          | 2  1  1  1        1  1  1        1     1  1  1  2                 1  1  1|             
      Pelvis, Inflammation                 |                                        2           2                    2|             
      Renal Tubule, Degeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                        3           2                    2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|             
                             DAY ON TEST   | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|             
                                           | 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation                         |                   2        1           3                       1        2|             
      Transitional Epithelium, Hyperplasia |                                        3                                2|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|             
                                           | 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3000                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    UG/KG                                  | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Parasite Metazoan                    |             X                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Parasite Metazoan                    |                                           X     X     X                 X|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         3                                                |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1           2                             1            |             
      Basophilic Focus                     |          X        X        X              X        X                     |             
      Basophilic Focus, Multiple           |                               X                                          |             
      Clear Cell Focus                     |                               X  X                                       |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |    X                    X  X     X                 X     X              X|             
      Fatty Change, Diffuse                |                               2  1        1  1  1           1            |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |             1        3  2  1           1           1                     |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         | 2  1     1  1  1  2  2  3     1  1  1  1     1  1  1  2  1  1  1  1  1  1|             
      Mixed Cell Focus                     |                                                    X                     |             
      Mixed Cell Focus, Multiple           |          X                    X  X              X              X         |             
      Necrosis                             |                         3  2                                      1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|             
                                           | 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3000                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    UG/KG                                  | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         |             1     1  1  1  1                                1            |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Fibrosis                  |                                  1                    1                  |             
      Bile Duct, Hyperplasia               | 1                 1  2        2  2  1           1     3                  |             
      Centrilobular, Degeneration          |                            2                    1                        |             
      Hepatocyte, Hypertrophy              | 2  1     3     3              2  2  3  2  3  3  2  2  3  2  3  3  2  3  2|             
      Oval Cell, Hyperplasia               |                   1  2                                                   |             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +     +     +  +                 +  +     +  +  +           +         |             
      Gingival, Hyperplasia, Squamous      |    1     1     1  1                 1  1     1  1  1           1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1                                                     1         |             
      Acinus, Atrophy                      |          1                                                     2         |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    2                                                                     |             
      Hyperplasia, Squamous                |    2                                   3                                 |             
      Inflammation                         |    3                                   3                                 |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +     +     +  +  +  +     +     +  +     +  +  +  +  +     +  +      |             
      Peridontal Tissue, Inflammation      | 1  1     1     1  1  4  4     1     1  1     1  2  1  1  1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1     1  1        1  1  1  1              1     2  1  1  1  1|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|             
                                           | 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3000                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    UG/KG                                  | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    4     2     2           3  2  2  2        1     2  1  2  2  2  2  1   |             
      Degeneration, Cystic                 |    2     2        2        2                       2              1      |             
      Hematopoietic Cell Proliferation     |                      1                 2                                 |             
      Hyperplasia                          |          3  3              1        3                 2              2  2|             
      Hypertrophy                          | 2  1     2  3  2  3  3     2  2  2  1  1  1  1  1  3  3  1  1  1  3     1|             
      Inflammation                         |             1                                                            |             
      Necrosis                             |             2              1                                             |             
      Vacuolization Cytoplasmic            |             1        2  1  1     2  1                 2           2  2  2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        1     2  3  1                             2        2  2     2  1|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                    2     2                 2        2     4  2  1      |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |    1  2  3     3  2  3           1  3     2  2  2     3  2           2  2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1        3        1  2  2  2        2     1        2        3  2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         |    2        2        3     1     2  1              2     2           2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      4                                                   |             
      Inflammation                         | 1  1     1  3  1  1     1  1  1  3  2  1  1  2  4  1  1  1  1  2  2  1  2|             
      Duct, Cyst                           | 1  2     4  3     2     3  3     2  2  2  3     2  2  3  2  3  2  3  3  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|             
                                           | 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3000                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    UG/KG                                  | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4  4  4     4  4     3     4  4  4  4  4        2  4  4  4  4     4|             
      Cyst                                 | 3        2     4              2                    2     3     2  2  2  2|             
      Inflammation, Chronic Active         | 4              3  4     4  3        3                                    |             
      Interstitial Cell, Hyperplasia       |                                                             3            |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  M  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         | 4                       4  4        3                                    |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          | 3                                                                        |             
      Inflammation, Chronic Active         |                   1  4  3  4                                             |             
      Inflammation, Suppurative            |                                  1                 1              3      |             
      Metaplasia, Squamous                 |          4     2  2        3     1  2     2  1     4  2  4     2  4     1|             
      Endometrium, Hyperplasia, Cystic     | 2                                2  2  1  2  2        3     1  2     1  4|             
                                           |__________________________________________________________________________|             
   Vagina                                  |             +                          +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  4  3     4  2  4  4  3  4     2  3  4  2     3  3  3  2  2  2  2  2  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +     +                                +                     |             
      Lumbar, Ectasia                      |             2                                                            |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |             2     2                                                      |             
      Mediastinal, Ectasia                 |                                                    1                     |             
      Renal, Ectasia                       |                   3                                                      |             
      Renal, Hyperplasia, Plasma Cell      |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Hyperplasia, Plasma Cell             | 2  2     2  2  3  2  3  3  2  2     2        3        3  2  3  3  2  2  3|             
      Inflammation                         |                         3                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|             
                                           | 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3000                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    UG/KG                                  | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                      3                                                   |             
      Inflammation, Chronic Active         |                      4                                                   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2     1  3  1  2  3  3  3  1  1  2  3  2  1  1  3  2  1     1  1  2  3|             
      Hemorrhage                           |             3                                                            |             
      Infarct                              |                                                                          |             
      Necrosis                             |             3                                                            |             
      Pigmentation                         | 2  1     2     2  1  1  1  1  2  2  1  1  1  2  1  1  1  2  3  2  1  2  1|             
      Lymphoid Follicle, Atrophy           |                      3  3                                                |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |    2  3  3        4  4  3  4     2  2  4  2     2     2        2  3      |             
      Cyst                                 |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             
      Hyperplasia                          |    1     1        1  2     1  2     2  1        2     1     1  1     3   |             
      Inflammation, Granulomatous          |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|             
                                           | 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3000                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    UG/KG                                  | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      1                                                   |             
      Infiltration Cellular, Histiocyte    |    1     1  1  1  1        2     1  2     2     2     1  1  1  1  2  1   |             
      Inflammation                         |             1                    2  2           2                 2     2|             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     1           1     1           1      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                2              2  2                                       |             
      Nasolacrimal Duct, Inflammation      |                   2                                                      |             
      Septum, Inflammation                 |                2           3     1        1     1                        |             
      Turbinate, Inflammation              |                      1     3  3  1                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                 1  3  1     1  1           1           1  1  2     1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Casts Protein                        |                                                             2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                               2     2                 2                  |             
      Mineralization                       | 1  1     1  1  1  1  1  1  1  1  1     1     1     1  1     1     1  1  1|             
      Nephropathy                          | 1  1     1     1  1  1     2  1  1  1  1     1        1     1  1  1  1  1|             
      Pelvis, Inflammation                 |                      2                                                   |             
      Renal Tubule, Degeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|             
                                           | 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3000                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    UG/KG                                  | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation                         |       2                                               3           1     2|             
      Transitional Epithelium, Hyperplasia |                                                       2                  |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 7|                                                                       |            |
                                           | 2|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 6|                                                                       |      A     |
    3000                                   | 2|                                                                       |      L     |
    UG/KG                                  | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      5     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  51        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  50        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      4  1.5|
      Basophilic Focus                     |                                                                          |      8     |
      Basophilic Focus, Multiple           |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      6     |
      Eosinophilic Focus, Multiple         |                                                                          |     12     |
      Fatty Change, Diffuse                | 1                                                                        |     17  1.2|
      Fatty Change, Focal                  |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |     14  1.2|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 7|                                                                       |            |
                                           | 2|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 6|                                                                       |      A     |
    3000                                   | 2|                                                                       |      L     |
    UG/KG                                  | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         | 1                                                                        |     45  1.3|
      Mixed Cell Focus                     |                                                                          |      3     |
      Mixed Cell Focus, Multiple           |                                                                          |     12     |
      Necrosis                             |                                                                          |     10  2.3|
      Pigmentation                         |                                                                          |      9  1.0|
      Bile Duct, Cyst                      |                                                                          |      2  2.5|
      Bile Duct, Fibrosis                  |                                                                          |      3  1.0|
      Bile Duct, Hyperplasia               |                                                                          |     17  1.6|
      Centrilobular, Degeneration          |                                                                          |      5  2.0|
      Hepatocyte, Hypertrophy              | 2                                                                        |     41  2.3|
      Oval Cell, Hyperplasia               |                                                                          |      4  1.3|
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +                                                                        |  25        |
      Gingival, Hyperplasia, Squamous      | 3                                                                        |     25  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Acinus, Atrophy                      |                                                                          |      2  1.5|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Squamous                |                                                                          |      4  2.5|
      Inflammation                         |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Mineralization                       |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |  35        |
      Peridontal Tissue, Inflammation      | 2                                                                        |     35  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 7|                                                                       |            |
                                           | 2|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 6|                                                                       |      A     |
    3000                                   | 2|                                                                       |      L     |
    UG/KG                                  | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Cardiomyopathy                       | 1                                                                        |     24  1.1|
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Angiectasis                          |                                                                          |     21  1.9|
      Degeneration, Cystic                 |                                                                          |     13  1.8|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.3|
      Hyperplasia                          |                                                                          |     11  2.5|
      Hypertrophy                          | 1                                                                        |     41  2.0|
      Inflammation                         |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      3  2.0|
      Vacuolization Cytoplasmic            |                                                                          |     14  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |     12  1.9|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  50        |
      Angiectasis                          | 3                                                                        |     14  2.3|
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     25  2.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      C-Cell, Hyperplasia                  |                                                                          |     16  1.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 7|                                                                       |            |
                                           | 2|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 6|                                                                       |      A     |
    3000                                   | 2|                                                                       |      L     |
    UG/KG                                  | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
      Follicular Cell, Hypertrophy         |                                                                          |     17  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation                         | 1                                                                        |     46  1.4|
      Duct, Cyst                           | 2                                                                        |     41  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  50        |
      Atrophy                              | 4                                                                        |     39  3.9|
      Cyst                                 |                                                                          |     17  2.2|
      Inflammation, Chronic Active         | 4                                                                        |      7  3.6|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +                                                                        |  45        |
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 4                                                                        |      7  3.3|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  50        |
      Adenomyosis                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      8  3.0|
      Inflammation, Suppurative            |                                                                          |      8  1.6|
      Metaplasia, Squamous                 | 3                                                                        |     32  2.6|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     21  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 7|                                                                       |            |
                                           | 2|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 6|                                                                       |      A     |
    3000                                   | 2|                                                                       |      L     |
    UG/KG                                  | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Bone Marrow                             | +                                                                        |  51        |
      Hyperplasia                          | 2                                                                        |     46  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Lumbar, Ectasia                      |                                                                          |      2  2.5|
      Lumbar, Hemorrhage                   |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      2  2.0|
      Mediastinal, Ectasia                 |                                                                          |      2  2.0|
      Renal, Ectasia                       |                                                                          |      2  3.5|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  51        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 3                                                                        |     38  2.3|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hematopoietic Cell Proliferation     | 1                                                                        |     47  1.7|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         | 2                                                                        |     46  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  47        |
      Atrophy                              |                                                                          |     30  2.6|
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 7|                                                                       |            |
                                           | 2|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 6|                                                                       |      A     |
    3000                                   | 2|                                                                       |      L     |
    UG/KG                                  | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Cyst                                 |                                                                          |      3  2.7|
      Hyperplasia                          |                                                                          |     22  1.4|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    | 1                                                                        |     28  1.3|
      Inflammation                         |                                                                          |      9  1.7|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Inflammation                         |                                                                          |      3  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      2  2.5|
      Septum, Inflammation                 |                                                                          |      6  1.5|
      Turbinate, Inflammation              | 1                                                                        |     10  1.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 7|                                                                       |            |
                                           | 2|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 6|                                                                       |      A     |
    3000                                   | 2|                                                                       |      L     |
    UG/KG                                  | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |  49        |
      Inflammation                         |                                                                          |     16  1.2|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  1.0|
      Calculus Micro Observation Only      |                                                                          |      1     |
      Casts Protein                        |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
      Mineralization                       | 1                                                                        |     41  1.0|
      Nephropathy                          | 3                                                                        |     34  1.1|
      Pelvis, Inflammation                 |                                                                          |      4  2.0|
      Renal Tubule, Degeneration           | 3                                                                        |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Inflammation                         |                                                                          |      9  1.9|
      Transitional Epithelium, Hyperplasia |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|             
                                           | 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                               1                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                    X|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2     2              3              1                              |             
      Basophilic Focus                     | X              X                          X                          X   |             
      Basophilic Focus, Multiple           |                                                                X         |             
      Clear Cell Focus                     |          X                                                               |             
      Degeneration, Cystic                 |                            2                                             |             
      Eosinophilic Focus                   |       X                 X                                                |             
      Eosinophilic Focus, Multiple         |          X     X              X           X  X     X  X        X         |             
      Fatty Change, Diffuse                | 1     2     2     1        1  1  1                          1     1      |             
      Fatty Change, Focal                  |                1                                      1        1         |             
      Hematopoietic Cell Proliferation     |    1  1     1  1  1  1        1              3        1     1  1         |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Nodular                 |             X                                                            |             
      Inflammation                         | 1  1  1  1  1  1  1     1  1  1  2  1  1     2  1  1     1  1  1        1|             
      Mixed Cell Focus                     |                      X                 X                 X           X   |             
      Mixed Cell Focus, Multiple           |             X  X  X        X  X           X                 X  X         |             
      Necrosis                             |    2                             3           2     3                     |             
      Pigmentation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|             
                                           | 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      | 3                                                              1         |             
      Bile Duct, Fibrosis                  |                               2     1  1                                 |             
      Bile Duct, Hyperplasia               | 1        1  2              2  3                          3        1     1|             
      Centrilobular, Degeneration          |    3     1                       3                                       |             
      Hepatocyte, Hypertrophy              | 2     2     2  1  1  2     2        2  2        2        2     1  3  3  1|             
      Oval Cell, Hyperplasia               |                                                          1               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +           +           +     +  +           +  +     +  +  +           +|             
      Gingival, Hyperplasia, Squamous      | 1           1           1     2  1           1  1     1  1  2           1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              1                           |             
      Acinus, Atrophy                      |                                              2                           |             
      Acinus, Hyperplasia                  |                            3                                            1|             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                       1                  |             
      Ulcer                                |                                                                          |             
      Serosa, Inflammation                 |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +  +           +     +  +  +     +     +  +  +  +  +  +        +|             
      Peridontal Tissue, Inflammation      | 2        2  1           2     3  1  1     1     1  1  1  1  2  1        2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|             
                                           | 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1        1  1        2     1     1     1  1  1        1            |             
      Epicardium, Inflammation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     1  2  1  2  2        2  1        1  1                 3  2        2|             
      Degeneration, Cystic                 | 2        2     1                                            3            |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hyperplasia                          | 3     2  4     2              2           2                 3  2     2  2|             
      Hypertrophy                          | 2     2     1  2  2  1     3           2  2  2  2  2  2  2  2  3     2  2|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 1           1  1              1           1                          1  2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Hyperplasia                          |       3        3                 2  1  3     2  2        3               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     2     2  3                       3     2  3           3     3  3  1|             
      Pars Distalis, Hyperplasia           |                   2        3                       3  2  2     3        3|             
      Rathke's Cleft, Pars Nervosa, Cyst   |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     1  2  2              2  2                             3            |             
      Follicular Cell, Hypertrophy         |          2  2  1  2     2  2     2     1                 2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|             
                                           | 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1     2  1  1  1  1  1  1  1  2  1  2  1  1  2        2  2  3  1  2  1|             
      Duct, Cyst                           | 3  2  2  1  3  2        1  3  2  3  2  3  2     3        2  3  2  1  2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4     4  4  4  4  4  4           4  4  4  4  4  3  3  4     4  4  4|             
      Cyst                                 |       2  2  3  2           2                 3     2     2     3         |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                    4                     |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              4                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                      3                                3           2      |             
      Metaplasia, Squamous                 | 2     2              3                 3  2           4  3  2     4     2|             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Hyperplasia, Stromal         |       3        3                                                         |             
      Endometrium, Hyperplasia, Cystic     | 2     3        1  1  3                    2     1        2  3        1  1|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
      Inflammation, Chronic Active         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  4  3  3  3  2  3  4  4     3  3        3  4  2  3  4  4     4     2   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
      Ectasia                              |             2                                                            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2     3  3  2  3  2     2  3  2  2  2  3     3     2  3  2     3  2     3|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|             
                                           | 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     | X                                                                        |             
      Congestion                           |       3                                                                  |             
      Hematopoietic Cell Proliferation     | 1  3  3  1  2  2  2  2  2  2  2  3     2  2  4     2  2  1  1  3        2|             
      Hemorrhage                           |                                                       2                  |             
      Pigmentation                         | 1  1  2  1  1  1  1  1  1  1  1  1  3  1  1  1  1  1  1  1  2  1  3  2  1|             
      Lymphoid Follicle, Atrophy           |                                  2                                2      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  4  2  3           2  2     2  4  3        2     2  2  2        2     2|             
      Hemorrhage                           |                                                                      3   |             
      Inflammation                         |                                              3                           |             
      Necrosis, Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cyst, Multiple                       |                                                       3                  |             
      Hyperplasia                          | 1     2  2  2        1     1  1  2  2  1           1     1  1  2  1      |             
      Inflammation, Granulomatous          |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|             
                                           | 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Hemorrhage                           |       2                                                                  |             
      Infiltration Cellular, Histiocyte    | 2  1     1  1  1  1  1  1  1  1  2     1  2  2     1  2     1  1     1  1|             
      Inflammation                         | 1                 1        2  1        2                                 |             
      Alveolar Epithelium, Hyperplasia     |                            1                          1                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2                                         1                        |             
      Septum, Inflammation                 |                                        1        2                        |             
      Turbinate, Inflammation              |                                        1  1     2                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                2                                                         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1  1  1                       1        1  1              1  1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |          1                                1                              |             
      Cyst                                 |                                                                      2   |             
      Fibrosis                             |                                                                1         |             
      Inflammation, Chronic Active         |                         4                          1                     |             
      Inflammation, Suppurative            | 2                                                                        |             
      Mineralization                       |    1  1  1  1  1     1     1  1  1  1  1  1  1  1  1     1  1  1  1  1  1|             
      Nephropathy                          | 1     3     1     1        1                    1        1  1           1|             
      Pelvis, Inflammation                 |                2  1     1                                                |             
      Transitional Epithelium, Hyperplasia |                1        1                                                |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                3  2     2                       1                        |             
      Transitional Epithelium, Hyperplasia |                2                                                         |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6|            |
                             DAY ON TEST   | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2|            |
                                           | 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      A     |
    3000 UG/                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Muscularis, Inflammation             | 1     2                                                                  |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      X                                                   |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  48        |
      Inflammation                         |             3                                                            |      1  3.0|
      Ulcer                                |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                1                                2     1        1         |      8  1.6|
      Basophilic Focus                     |                         X        X                    X           X      |      8     |
      Basophilic Focus, Multiple           |                                              X                           |      2     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                    X                 X   |      4     |
      Eosinophilic Focus, Multiple         |                               X              X                           |     10     |
      Fatty Change, Diffuse                |                                        1  1     1  1  1  1               |     15  1.1|
      Fatty Change, Focal                  | 1                             2                                         1|      6  1.2|
      Hematopoietic Cell Proliferation     | 1        1           1                       1           2           2   |     17  1.2|
      Hepatodiaphragmatic Nodule           |                                        X              X                  |      2     |
      Hyperplasia, Histiocytic             |                                                                      2   |      1  2.0|
      Hyperplasia, Nodular                 |                                                                          |      1     |
      Inflammation                         | 1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   |     44  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6|            |
                             DAY ON TEST   | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2|            |
                                           | 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      A     |
    3000 UG/                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus                     |    X                          X                       X                  |      7     |
      Mixed Cell Focus, Multiple           |                X     X  X        X     X                                 |     13     |
      Necrosis                             |          3        3                          3              2        3   |      9  2.7|
      Pigmentation                         |                         1        1           2                           |      3  1.3|
      Bile Duct, Cyst                      |                                  2                                       |      3  2.0|
      Bile Duct, Fibrosis                  |                                                       1           1      |      5  1.2|
      Bile Duct, Hyperplasia               |                1                                2              2  1      |     12  1.7|
      Centrilobular, Degeneration          |       2                                      2                           |      5  2.2|
      Hepatocyte, Hypertrophy              | 1  2        2  2     2  1  2  2  1     1  3     1  2  2        3  1     2|     32  1.8|
      Oval Cell, Hyperplasia               |                                                                1         |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +              +                          +     +                        |  15        |
      Gingival, Hyperplasia, Squamous      | 1              1                          1     1                        |     15  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                        1                                 |      2  1.0|
      Acinus, Atrophy                      | 2                                      2                                 |      3  2.0|
      Acinus, Hyperplasia                  |                                                                          |      2  2.0|
      Acinus, Vacuolization Cytoplasmic    |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |       2           2                                                      |      2  2.0|
      Hyperplasia, Squamous                |       4           2           1                          1           2   |      5  2.0|
      Inflammation                         |       2           1                                      1           2   |      4  1.5|
      Mineralization                       |       1  3                                                               |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |       3                                                                  |      1  3.0|
      Mineralization                       | 2     1                                                                  |      3  1.3|
      Ulcer                                |       3                                                                  |      1  3.0|
      Serosa, Inflammation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6|            |
                             DAY ON TEST   | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2|            |
                                           | 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      A     |
    3000 UG/                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +              +     +  +  +  +           +  +  +  +     +              +|  27        |
      Peridontal Tissue, Inflammation      | 1              1     1  1  1  1           2  1  2  1     1              2|     27  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |             1                                         1        1  1      |     15  1.1|
      Epicardium, Inflammation             |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                 2     1     2              2                 2     1|     20  1.7|
      Degeneration, Cystic                 |                                  2        1        1                     |      7  1.7|
      Hematopoietic Cell Proliferation     |                   1                                                      |      2  1.5|
      Hyperplasia                          |                2                 2     2  3     2  2     1     3         |     18  2.3|
      Hypertrophy                          |    2           2  1  2  2  1  2        2     1  2  2  1  1  2  1  1     2|     35  1.8|
      Necrosis                             |                   2                                                      |      1  2.0|
      Vacuolization Cytoplasmic            |             1              1           1     1                 1         |     12  1.1|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |    3     2  3     1     2        2     1           2  1           4     2|     19  2.2|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +|  45        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2           1  2     1  3     3  1     2  3        2  3        2        3|     24  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6|            |
                             DAY ON TEST   | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2|            |
                                           | 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      A     |
    3000 UG/                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Distalis, Hyperplasia           |    3     3  2  3  4                 2        1  2           2     2  2   |     18  2.4|
      Rathke's Cleft, Pars Nervosa, Cyst   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |    1                 2           1     2     2     3                     |     13  1.9|
      Follicular Cell, Hypertrophy         |       2                    2                       2                     |     12  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         | 1  2  1  1     3  1  1  1     2  2  3  1     1  1  1  1  1  2  2  3  2  2|     44  1.5|
      Duct, Cyst                           | 2  3  3  2  2        3  2  2  3  3  4  2     2     1  1  3  3  3  3  3  3|     41  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 4  4  4     3  4  4  4  4  4  4  4  4  4     4  4  4  4  4     4  4     4|     41  3.9|
      Cyst                                 |                3  3     2        3  2              2           3         |     16  2.4|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  46        |
      Dilatation                           |                                  3                                       |      1  3.0|
      Inflammation, Chronic Active         |                      2                                                   |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                        3                                 |      1  3.0|
      Inflammation, Suppurative            |    2  1     2              3                          3        1         |      9  2.2|
      Metaplasia, Squamous                 | 2  3           2     2  4  3     3     4        3  4  3        2  1     2|     24  2.7|
      Cervix, Cyst                         |                                  3                                       |      1  3.0|
      Cervix, Hyperplasia, Stromal         |                                                                          |      2  3.0|
      Endometrium, Hyperplasia, Cystic     | 1  2  2     2  1     2           1              1        1     4  3     2|     23  1.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6|            |
                             DAY ON TEST   | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2|            |
                                           | 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      A     |
    3000 UG/                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3     4  4  2     4  2  3  2  2  3  3  2     3     2  4  4  3  3  3  4  2|     40  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                +         |   1        |
      Mediastinal, Hemorrhage              |                                                                2         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                      3   |      1  3.0|
      Hyperplasia, Plasma Cell             | 2     3        2  4  3  3  2  2  3     2  3  2     2  3     2  3  3     3|     37  2.5|
      Inflammation                         |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 3  1  2  2     1  3  2  1  2  1  2  1  1     3  1  1  1  3  1  1  1  3  1|     44  1.9|
      Hemorrhage                           |                                                                          |      1  2.0|
      Pigmentation                         | 1  2  1  1  2  2  1  1  2  2  1  1  1  1  2  1  1  1  1  1  1  1  2  1  2|     50  1.3|
      Lymphoid Follicle, Atrophy           |             3                             2                              |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |       3  3  3  2  3     3     2     2  2     3     2        3  2  2      |     29  2.4|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Necrosis, Lymphoid                   |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6|            |
                             DAY ON TEST   | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2|            |
                                           | 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      A     |
    3000 UG/                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   2                                   3                 2|      3  2.3|
      Cyst, Multiple                       |                                                                          |      1  3.0|
      Hyperplasia                          |    1     1     2  1     2        2              2  2  2        2  1     1|     27  1.5|
      Inflammation, Granulomatous          |                                                    1                     |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |    1     1  1  1  1  1  1     1     2  2  1     2  1  1           2  2  1|     37  1.3|
      Inflammation                         |                      2                    3     2                 2      |      9  1.8|
      Alveolar Epithelium, Hyperplasia     |                                                 2                 1      |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  1.5|
      Septum, Inflammation                 | 1                                         1                              |      4  1.3|
      Turbinate, Inflammation              | 1                                         1                              |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 10/09/03    
Route: GAVAGE                                                                                                     Time: 09:34:57    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6|            |
                             DAY ON TEST   | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2|            |
                                           | 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      A     |
    3000 UG/                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Retina, Atrophy                      |             2                                                            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                         2     1     2                 1        2  1      |     15  1.2|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts Protein                        |                            1                    1                        |      4  1.0|
      Cyst                                 |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                   3      |      3  2.7|
      Inflammation, Suppurative            |                      2                                                   |      2  2.0|
      Mineralization                       |    1     1     1  1  1  1     1  1     1  1  1  1  1        1  1  1     1|     38  1.0|
      Nephropathy                          |    1        3  1     1  1     1        1           1  1     1  1  1     1|     22  1.2|
      Pelvis, Inflammation                 |                                                                          |      3  1.3|
      Transitional Epithelium, Hyperplasia |                                     2                             2      |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                     2  1     1              2     2  1   |     10  1.7|
      Transitional Epithelium, Hyperplasia |                                     2        2                           |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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