Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/17067

TDMS Study 96021-01 Pathology Tables

NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03
Route: GAVAGE                                                                                                     Time: 11:03:02

                                                          FINAL#4 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  35065-27-1

       Lock Date:  01/16/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































Note:  Animals arranged according to days on test

                                                              Page   1


NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|             
                                           | 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|             
                                           | 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +        +        +     +        +     +  +                    +  +      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +        +  +  +     +  +     +  +     +  +     +  +  +  +  +  +|             
      Peridontal Tissue, Neurofibrosarcoma |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Hemangiosarcoma, Metastatic,  |                                                                          |             
           Heart                           |                X                                                         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|             
                                           | 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|             
                                           | 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Heart                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                              X                           |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                  X                                       |             
      Pars Distalis, Adenoma               | X                                         X                 X     X  X  X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                            X           X                    X     X      |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|             
                                           | 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|             
                                           | 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                        X                                 |             
      Polyp Stromal, Multiple              |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lipoma                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +     +              +                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Heart   |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Adenoma, Multiple                    |                                                                          |             
      Carcinoma                            |                                              X                           |             
      Fibroadenoma                         |    X  X  X     X  X        X  X              X        X  X     X         |             
      Fibroadenoma, Multiple               |                      X  X              X        X  X              X  X  X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Vagina                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|             
                                           | 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|             
                                           | 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                X                                                         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|             
                                           | 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                               X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +                 +  +  +     +        +     +  +                    +|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +     +           +  +  +     +     +  +  +  +  +     +  +  +         |             
      Peridontal Tissue, Neurofibrosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Hemangiosarcoma, Metastatic,  |                                                                          |             
           Heart                           |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|             
                                           | 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |       X                                   X                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                                                            |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |             
      Pars Distalis, Adenoma               |    X     X  X     X        X  X              X  X  X              X      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                    X                     |             
      C-Cell, Adenoma                      |       X  X        X        X     X        X     X                 X  X   |             
      C-Cell, Carcinoma                    |                                                       X  X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|             
                                           | 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |    X     X           X                             X                    X|             
      Polyp Stromal, Multiple              |                         X                                                |             
                                           |__________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
      Schwannoma Malignant                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lipoma                               |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
      Adenoma, Multiple                    |                                  X                                       |             
      Carcinoma                            |    X              X        X     X        X              X        X      |             
      Fibroadenoma                         |          X        X  X     X        X  X                 X  X  X  X      |             
      Fibroadenoma, Multiple               | X     X     X  X                 X           X  X  X                 X  X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Vagina                          |    X                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|             
                                           | 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Lymphoma Malignant                   |                                  X                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 UG/KG                                | 5| 7| 7|                                                                 |     L      |
                                           | 4| 2| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Leiomyoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +                                                                     |  21        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  34        |
      Peridontal Tissue, Neurofibrosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 UG/KG                                | 5| 7| 7|                                                                 |     L      |
                                           | 4| 2| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Blood Vessel                            | +  +  +                                                                  |  52        |
      Aorta, Hemangiosarcoma, Metastatic,  |                                                                          |            |
           Heart                           |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |          1 |
      Pars Distalis, Adenoma               |    X  X                                                                  |         18 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      Bilateral, C-Cell, Adenoma           |       X                                                                  |          2 |
      C-Cell, Adenoma                      | X                                                                        |         14 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 UG/KG                                | 5| 7| 7|                                                                 |     L      |
                                           | 4| 2| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Cystadenoma                          |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Polyp Stromal                        |                                                                          |          6 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Lipoma                               |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  48        |
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 UG/KG                                | 5| 7| 7|                                                                 |     L      |
                                           | 4| 2| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma                            |                                                                          |          8 |
      Fibroadenoma                         | X                                                                        |         22 |
      Fibroadenoma, Multiple               |       X                                                                  |         19 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Vagina                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Mediastinum, Hemangiosarcoma,        |                                                                          |            |
          Metastatic, Heart                |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 UG/KG                                | 5| 7| 7|                                                                 |     L      |
                                           | 4| 2| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Neurofibrosarcoma, Metastatic, Tooth |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                             DAY ON TEST   | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|             
                                           | 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|             
                                           | 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                +     +              +     +     +                 +      |             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +        +                    +     +     +                 +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                             DAY ON TEST   | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|             
                                           | 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|             
                                           | 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |             
      Pars Distalis, Adenoma               |                                                 X                 X     X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                                     X                    X               |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                              X                           |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Polyp Stromal                        |                                                                      X  X|             
      Schwannoma Malignant                 |                                                 X                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                             DAY ON TEST   | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|             
                                           | 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|             
                                           | 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Squamous Cell Carcinoma      |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
      Fibrosarcoma                         |       X                                                                  |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +                             +     +            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |    X                 X  X                                   X     X      |             
      Fibroadenoma                         |             X     X        X  X     X  X                 X  X  X  X     X|             
      Fibroadenoma, Multiple               |                X                                      X              X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Fibrosarcoma                         |             X                                                            |             
      Keratoacanthoma                      |                                                                          |             
      Sarcoma                              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                             DAY ON TEST   | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|             
                                           | 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|             
                                           | 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                      X                                                   |             
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Stromal Nephroma                     |                                           X                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|             
                                           | 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +                 +           +     +     +                 +         |             
      Gingival, Squamous Cell Carcinoma    |    X                                   X                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +                 +           +     +     +           +     +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|             
                                           | 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |    X                                                                     |             
      Pars Distalis, Adenoma               | X     X     X        X           X  X        X  X  X  X  X  X        X   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                X                       X     X                    X      |             
      C-Cell, Adenoma                      |                                           X     X  X  X        X         |             
      C-Cell, Carcinoma                    |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 | M  +  M  M  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                               X                                          |             
      Polyp Stromal                        | X                 X                          X  X              X        X|             
      Schwannoma Malignant                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|             
                                           | 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Squamous Cell Carcinoma      |                            X                                             |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                            +                                             |             
      Fibrosarcoma                         |                                                                          |             
      Sarcoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                              X                           |             
      Fibroadenoma                         |       X        X     X                    X     X  X  X        X        X|             
      Fibroadenoma, Multiple               | X        X              X        X     X     X           X  X     X  X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                               X                                          |             
      Fibrosarcoma                         |                                                                          |             
      Keratoacanthoma                      |                                              X                           |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 UG/KG                               | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|             
                                           | 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Carcinoma, Metastatic, Oral Mucosa   |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Stromal Nephroma                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 3| 3| 3| 3|                                                              |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |     A      |
    10 UG/KG                               | 0| 2| 3| 8|                                                              |     L      |
                                           | 1| 8| 8| 1|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  12        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  52        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 3| 3| 3| 3|                                                              |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |     A      |
    10 UG/KG                               | 0| 2| 3| 8|                                                              |     L      |
                                           | 1| 8| 8| 1|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  54        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +                                                               |  54        |
      Pheochromocytoma Malignant           |    X                                                                     |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +                                                               |  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  54        |
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |          1 |
      Pars Distalis, Adenoma               | X     X  X                                                               |         19 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  52        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          4 |
      C-Cell, Adenoma                      |    X     X                                                               |          9 |
      C-Cell, Carcinoma                    | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +                                                               |  51        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 3| 3| 3| 3|                                                              |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |     A      |
    10 UG/KG                               | 0| 2| 3| 8|                                                              |     L      |
                                           | 1| 8| 8| 1|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +                                                               |  53        |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  M  +                                                               |  38        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  54        |
      Carcinoma                            |                                                                          |          1 |
      Polyp Stromal                        |          X                                                               |          9 |
      Schwannoma Malignant                 |                                                                          |          1 |
      Cervix, Squamous Cell Carcinoma      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +                                                                        |   3        |
      Fibrosarcoma                         | X                                                                        |          2 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +                                                               |  52        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  53        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 3| 3| 3| 3|                                                              |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |     A      |
    10 UG/KG                               | 0| 2| 3| 8|                                                              |     L      |
                                           | 1| 8| 8| 1|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
   Mammary Gland                           | +  +  +  +                                                               |  54        |
      Carcinoma                            |                                                                          |          6 |
      Fibroadenoma                         |       X                                                                  |         21 |
      Fibroadenoma, Multiple               |                                                                          |         13 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  54        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  54        |
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  54        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 3| 3| 3| 3|                                                              |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |     A      |
    10 UG/KG                               | 0| 2| 3| 8|                                                              |     L      |
                                           | 1| 8| 8| 1|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Eye                                     | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +                                                               |  54        |
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  54        |
      Stromal Nephroma                     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +                                                               |  54        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|             
                                           | 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|             
    UG/KG                                  | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +              +  +     +              +        +                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +                 +     +        +     +                 +  +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|             
                                           | 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|             
    UG/KG                                  | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                                         X     X     X     X        X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X                    X                    X        X     X     X|             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |          X                                                               |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Granulosa-Theca Tumor Benign         |                                                                          |             
      Schwannoma Malignant                 |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                       X                  |             
      Polyp Stromal                        |                                  X                                       |             
      Squamous Cell Carcinoma              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|             
                                           | 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|             
    UG/KG                                  | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Carcinoma                    |                               X                                          |             
      Cervix, Schwannoma Malignant         |                                                                         X|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                +                                                         |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +                       +                             +      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |          X     X              X     X                    X               |             
      Fibroadenoma                         | X  X  X     X     X     X        X              X        X  X        X   |             
      Fibroadenoma, Multiple               |                      X                       X                    X      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                           X                              |             
      Fibrous Histiocytoma                 |                                                 X                        |             
      Lipoma                               |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|             
                                           | 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|             
    UG/KG                                  | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal Tubule, Adenoma                |                                                                X         |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                               +                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|             
    UG/KG                                  | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +                                               +  +      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +     +  +     +                    +  +                 +  +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|             
    UG/KG                                  | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                 X        X              X|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                              X                           |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X        X     X  X  X           X           X  X     X     X  X   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |       X  X                 X              X  X  X  X  X        X     X   |             
      C-Cell, Carcinoma                    | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                             X            |             
      Granulosa-Theca Tumor Benign         |                                                    X                     |             
      Schwannoma Malignant                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Polyp Stromal                        | X                                         X                              |             
      Squamous Cell Carcinoma              |                                  X                                      X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|             
    UG/KG                                  | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Carcinoma                    |                                                                          |             
      Cervix, Schwannoma Malignant         |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                      +                                                   |             
      Squamous Cell Carcinoma              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                                                  |             
      Carcinoma                            |                         X                          X                     |             
      Fibroadenoma                         | X        X           X  X           X     X     X        X     X  X     X|             
      Fibroadenoma, Multiple               |       X     X     X        X  X              X     X  X     X        X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                         X|             
      Fibrous Histiocytoma                 |                                                                          |             
      Lipoma                               |                                                       X                  |             
      Subcutaneous Tissue, Sarcoma         |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100                                    | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|             
    UG/KG                                  | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal Tubule, Adenoma                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    100                                    | 7| 7| 9|                                                                 |     L      |
    UG/KG                                  | 4| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +                                                                     |  16        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  19        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    100                                    | 7| 7| 9|                                                                 |     L      |
    UG/KG                                  | 4| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Benign              |    X                                                                     |          4 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               | X  X                                                                     |         19 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |    X                                                                     |         17 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    100                                    | 7| 7| 9|                                                                 |     L      |
    UG/KG                                  | 4| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Granulosa-Theca Tumor Benign         |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  M  +                                                                  |  44        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          1 |
      Polyp Stromal                        |    X                                                                     |          4 |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Cervix, Carcinoma                    |                                                                          |          1 |
      Cervix, Schwannoma Malignant         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    100                                    | 7| 7| 9|                                                                 |     L      |
    UG/KG                                  | 4| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          7 |
      Fibroadenoma                         |                                                                          |         22 |
      Fibroadenoma, Multiple               | X                                                                        |         14 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Fibroma                              |                                                                          |          2 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Lipoma                               |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    100                                    | 7| 7| 9|                                                                 |     L      |
    UG/KG                                  | 4| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|             
                                           | 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|             
    UG/KG                                  | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                     +                                   +|             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +              +                 +     +              +  +           +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|             
                                           | 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|             
    UG/KG                                  | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                   X              X              X  X        X        X  X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                     X  X                                 |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      C-Cell, Carcinoma                    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  M     +  M  +  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|             
                                           | 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|             
    UG/KG                                  | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
      Polyp Stromal                        |                                                                X  X      |             
      Schwannoma Malignant                 |                                                                X         |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                +         |             
      Squamous Cell Carcinoma              |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                   +      |             
      Mediastinal, Histiocytic Sarcoma     |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |       X                                         X                        |             
      Carcinoma, Multiple                  |                                                                          |             
      Fibroadenoma                         |          X     X     X  X              X  X  X  X  X  X  X              X|             
      Fibroadenoma, Multiple               |                               X     X                       X            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|             
                                           | 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|             
    UG/KG                                  | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Keratoacanthoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Nephroblastoma                       |    X                                                                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|             
                                           | 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|             
    UG/KG                                  | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|             
    UG/KG                                  | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |             +     +     +  +  +  +           +              +     +      |             
      Gingival, Squamous Cell Carcinoma    |                            X                                             |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +     +  +  +  +  +     +  +           +  +        +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|             
    UG/KG                                  | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Schwannoma Malignant                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                  X                 X     X  X            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X     X  X           X  X  X        X  X     X  X           X   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X  X     X              X  X  X                 X     X                  |             
      C-Cell, Adenoma, Multiple            |                                           X                              |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  M  M  M  M  +  M  +  +  +  +  +  M  +  M  +  +  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|             
    UG/KG                                  | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                      X  X                                                |             
      Polyp Stromal                        |          X              X                             X              X   |             
      Schwannoma Malignant                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Carcinoma                            |                   X                 X                                    |             
      Carcinoma, Multiple                  |                X                                                         |             
      Fibroadenoma                         |       X     X     X  X                 X     X           X  X        X   |             
      Fibroadenoma, Multiple               | X  X     X                 X  X           X     X              X  X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|             
    UG/KG                                  | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |       X                                                                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Keratoacanthoma                      |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Nephroblastoma                       |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|             
    UG/KG                                  | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    300                                    | 2| 9| 9|                                                                 |     L      |
    UG/KG                                  | 8| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |  12        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |  22        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    300                                    | 2| 9| 9|                                                                 |     L      |
    UG/KG                                  | 8| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Benign              |                                                                          |          4 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               | X                                                                        |         19 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |    X                                                                     |         11 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    300                                    | 2| 9| 9|                                                                 |     L      |
    UG/KG                                  | 8| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Clitoral Gland                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | M  +  +                                                                  |  35        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Leiomyosarcoma                       |    X                                                                     |          3 |
      Polyp Stromal                        |                                                                          |          6 |
      Schwannoma Malignant                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Mediastinal, Histiocytic Sarcoma     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    300                                    | 2| 9| 9|                                                                 |     L      |
    UG/KG                                  | 8| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          4 |
      Carcinoma, Multiple                  |                                                                          |          1 |
      Fibroadenoma                         | X                                                                        |         22 |
      Fibroadenoma, Multiple               |    X                                                                     |         13 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Fibroma                              |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Astrocytoma Malignant                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    300                                    | 2| 9| 9|                                                                 |     L      |
    UG/KG                                  | 8| 3| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Nephroblastoma                       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|             
                                           | 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|             
    UG/KG                                  | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
      Cholangioma                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +  +           +                          +     +                  |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +  +        +  +        +  +  +           +     +           +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|             
                                           | 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|             
    UG/KG                                  | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                        X     X  X     X  X  X  X         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                     X                                    |             
      C-Cell, Adenoma                      |                                              X           X     X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  M  +  M  +  +  +  M  +  +     +  +  +  +  +  M  +  M  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|             
                                           | 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|             
    UG/KG                                  | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                                          |             
      Polyp Stromal                        |             X                                                  X         |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                         +                                                |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                 +                                                      |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Uterus                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |          X  X                                                            |             
      Fibroadenoma                         | X  X     X     X     X     X  X        X  X  X        X     X        X   |             
      Fibroadenoma, Multiple               |                                  X  X              X           X  X     X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                           X                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|             
                                           | 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|             
    UG/KG                                  | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Fibrous Histiocytoma                 |                         X                                                |             
      Squamous Cell Papilloma              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Mammary Gland |             X                                                            |             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________|__________________________________________________________________________              
                                           | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|             
                                           | 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|             
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|             
    UG/KG                                  | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|             
 _____________________________________________________________________________________________________________________              
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                   X              X                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|             
    UG/KG                                  | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                      X                                                   |             
      Cholangioma                          |          X                    X                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Carcinoma, Metastatic, Uterus        |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +           +  +  +           +           +  +  +  +               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +           +     +  +     +  +           +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|             
    UG/KG                                  | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                               X                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  M  +  M  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X  X  X  X  X  X     X  X  X              X  X  X     X     X  X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                              X        X     X  X         |             
      C-Cell, Adenoma                      | X           X  X           X  X  X        X     X  X     X           X  X|             
      C-Cell, Carcinoma                    |                                     X              X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  M  +  +     +  +  M  +  +  +  +  +  M  +  M  M  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|             
    UG/KG                                  | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                      X                                                   |             
      Polyp Stromal                        |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                             +                     |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                    X                     |             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Uterus                          |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X     X           X                              |             
      Carcinoma                            |                               X           X  X           X               |             
      Fibroadenoma                         |    X     X           X        X     X  X     X  X  X     X     X     X  X|             
      Fibroadenoma, Multiple               | X     X        X  X        X                                             |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|             
    UG/KG                                  | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibroma                              |                                                 X                        |             
      Fibrosarcoma                         |                X                                                         |             
      Fibrous Histiocytoma                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X               |             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Carcinoma, Metastatic, Uterus        |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________|__________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000                                   | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|             
    UG/KG                                  | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|             
 _____________________________________________________________________________________________________________________              
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                   X                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1000                                   | 5| 6| 9|                                                                 |     L      |
    UG/KG                                  | 5| 9| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Cholangioma                          |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +                                                                     |  16        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  23        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1000                                   | 5| 6| 9|                                                                 |     L      |
    UG/KG                                  | 5| 9| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Benign              |    X                                                                     |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  46        |
      Adenoma                              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               | X  X                                                                     |         24 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          5 |
      C-Cell, Adenoma                      | X     X                                                                  |         17 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1000                                   | 5| 6| 9|                                                                 |     L      |
    UG/KG                                  | 5| 9| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Ovary                                   | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  +                                                                  |  39        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   5        |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Uterus                          |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1000                                   | 5| 6| 9|                                                                 |     L      |
    UG/KG                                  | 5| 9| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          6 |
      Fibroadenoma                         |       X                                                                  |         27 |
      Fibroadenoma, Multiple               | X                                                                        |         12 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Fibroma                              |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         | X                                                                        |          2 |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    1000                                   | 5| 6| 9|                                                                 |     L      |
    UG/KG                                  | 5| 9| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Lymphoma Malignant                   |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                             DAY ON TEST   | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|             
                                           | 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|             
    3000                                   | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|             
    UG/KG                                  | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +        +        +        +  +        +  +     +  +     +        +  +|             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +                 +  +     +  +  +     +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                                                   X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                             DAY ON TEST   | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|             
                                           | 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|             
    3000                                   | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|             
    UG/KG                                  | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                             X            |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                  X                          X            |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                                                          |             
      Cervix, Schwannoma Malignant,        |                                                                          |             
          Metastatic, Vagina               |                                           X                              |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                      +                    +                              |             
      Schwannoma Malignant                 |                      X                    X                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                             DAY ON TEST   | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|             
                                           | 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|             
    3000                                   | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|             
    UG/KG                                  | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                          +     +                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Carcinoma                            | X                                                                 X      |             
      Fibroadenoma                         |    X  X        X  X        X  X  X              X  X  X        X  X      |             
      Fibroadenoma, Multiple               |          X                          X        X                       X  X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                         X                                                |             
      Schwannoma Malignant                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                             DAY ON TEST   | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|             
                                           | 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|             
    3000                                   | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|             
    UG/KG                                  | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma, Metastatic,    |                                                                          |             
           Skin                            |                         X                                                |             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Stromal Nephroma                     |             X                                                            |             
      Bilateral, Renal Tubule, Carcinoma   |                                                          X               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|             
    3000                                   | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|             
    UG/KG                                  | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                               X                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +        +  +  +  +  +  +  +           +  +        +     +  +      |             
      Gingival, Squamous Cell Carcinoma    |                                              X                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +        +  +  +  +  +  +  +  +        +  +  +     +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|             
    3000                                   | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|             
    UG/KG                                  | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                         X                                                |             
      Bilateral, Pheochromocytoma Benign   |          X                                                               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X  X  X  X                 X              X     X  X  X         |             
      Pars Distalis, Carcinoma             |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X                          X     X  X                 X   |             
      C-Cell, Adenoma, Multiple            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                                 X                        |             
      Cervix, Schwannoma Malignant,        |                                                                          |             
          Metastatic, Vagina               |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
      Schwannoma Malignant                 |                                                       X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|             
    3000                                   | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|             
    UG/KG                                  | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +                                      +           +      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                               X  X     X  X     X  X  X     X  X  X  X  X|             
      Fibroadenoma, Multiple               | X           X                                                            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|             
    3000                                   | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|             
    UG/KG                                  | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Carcinoma, Metastatic, Mammary Gland |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                        X                                 |             
      Stromal Nephroma                     |                                                                          |             
      Bilateral, Renal Tubule, Carcinoma   |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 3|                                                                       |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |     T      |
                               ANIMAL ID   | 6|                                                                       |     A      |
    3000                                   | 1|                                                                       |     L      |
    UG/KG                                  | 3|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Hepatocellular Adenoma               |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  25        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |  35        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 3|                                                                       |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |     T      |
                               ANIMAL ID   | 6|                                                                       |     A      |
    3000                                   | 1|                                                                       |     L      |
    UG/KG                                  | 3|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Blood Vessel                            | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Pheochromocytoma Benign              |                                                                          |          2 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  50        |
      Pars Distalis, Adenoma               |                                                                          |         11 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      C-Cell, Adenoma                      | X                                                                        |          6 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 3|                                                                       |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |     T      |
                               ANIMAL ID   | 6|                                                                       |     A      |
    3000                                   | 1|                                                                       |     L      |
    UG/KG                                  | 3|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Ovary                                   | +                                                                        |  50        |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +                                                                        |  45        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  50        |
      Polyp Stromal                        | X                                                                        |          2 |
      Cervix, Schwannoma Malignant,        |                                                                          |            |
          Metastatic, Vagina               |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Schwannoma Malignant                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          2 |
      Fibroadenoma                         |                                                                          |         24 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 3|                                                                       |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |     T      |
                               ANIMAL ID   | 6|                                                                       |     A      |
    3000                                   | 1|                                                                       |     L      |
    UG/KG                                  | 3|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma, Multiple               | X                                                                        |          8 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Basal Cell Carcinoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 3|                                                                       |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |     T      |
                               ANIMAL ID   | 6|                                                                       |     A      |
    3000                                   | 1|                                                                       |     L      |
    UG/KG                                  | 3|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Stromal Nephroma                     |                                                                          |          1 |
      Bilateral, Renal Tubule, Carcinoma   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|             
                                           | 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|             
    KG STOP                                | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangioma                          |                                                                          |             
      Cholangioma, Multiple                |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +        +                    +        +                    +  +|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Adenoma                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +  +  +  +        +        +  +     +  +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|             
                                           | 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|             
    KG STOP                                | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                     X     X                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                          X               |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X  X                          X  X  X     X           X   |             
      Pars Distalis, Carcinoma             |                               X                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X                 X                          X  X  X      |             
      C-Cell, Carcinoma                    |                                                                X        X|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|             
                                           | 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|             
    KG STOP                                | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Granulosa-Theca Tumor Benign         |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Polyp Stromal                        |                                              X  X                        |             
      Cervix, Schwannoma Malignant         |                                                             X            |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |       X                                   X     X                       X|             
      Fibroadenoma                         |          X           X  X  X     X                 X  X     X  X         |             
      Fibroadenoma, Multiple               |                                     X  X                 X        X  X  X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Fibroma                              |                   X                                                      |             
      Fibrosarcoma                         | X                                         X                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|             
                                           | 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|             
    KG STOP                                | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrous Histiocytoma                 |                                                       X                  |             
      Schwannoma Malignant                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                               X                                          |             
      Meninges, Sarcoma                    |                X                                                         |             
      Meninges, Schwannoma Malignant,      |                                                                          |             
          Metastatic, Skin                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |       X                                                                  |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Optic Nerve, Schwannoma Malignant,   |                                                                          |             
           Metastatic, Skin                |             X                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|             
                                           | 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3000 UG/                               | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|             
    KG STOP                                | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                       X                  |             
      Stromal Nephroma                     |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    3000 UG/                               | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9|     L      |
    KG STOP                                | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosarcoma                         |                                        X                                 |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cholangioma                          |                                              X                           |          1 |
      Cholangioma, Multiple                |                                        X                                 |          1 |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |       +  +        +     +  +                 +  +                 +     +|  15        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Adenoma                      |                      X                                                   |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +     +  +  +     +     +  +  +  +           +  +        +        +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    3000 UG/                               | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9|     L      |
    KG STOP                                | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              | X        X                          X  X                                 |          6 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                X                                                         |          1 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Adenoma                              |                                     X                                    |          1 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |    X     X     X  X     X     X  X  X  X     X        X  X  X  X  X  X   |         23 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |       X     X     X        X     X  X  X  X  X  X           X        X  X|         18 |
      C-Cell, Carcinoma                    |                                        X                                 |          3 |
      Follicular Cell, Adenoma             |                X                                                  X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    3000 UG/                               | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9|     L      |
    KG STOP                                | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cystadenoma                          |                         X                                                |          1 |
      Granulosa-Theca Tumor Benign         |                      X                                                   |          1 |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma                            |    X                                                                     |          1 |
      Polyp Stromal                        |       X                 X                                                |          4 |
      Cervix, Schwannoma Malignant         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                        +                                 |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    3000 UG/                               | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9|     L      |
    KG STOP                                | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |    X     X                 X     X              X                    X   |         10 |
      Fibroadenoma                         |             X  X  X                 X     X           X           X      |         16 |
      Fibroadenoma, Multiple               | X  X  X              X  X        X                       X  X            |         14 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Carcinoma                 |                   X                                                      |          1 |
      Fibroma                              |                               X                                          |          2 |
      Fibrosarcoma                         |             X                                X                           |          4 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Meninges, Sarcoma                    |                                                                          |          1 |
      Meninges, Schwannoma Malignant,      |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96021-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 12/15/03    
Route: GAVAGE                                                                                                     Time: 11:03:02    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    3000 UG/                               | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9|     L      |
    KG STOP                                | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Carcinoma, Metastatic,    |                                                                          |            |
           Skin                            |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Optic Nerve, Schwannoma Malignant,   |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Stromal Nephroma                     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------