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TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:20:54

                                                     53 WEEK SSAC FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/16/99 - 09/17/99

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 004    300 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 006    300 NG /3000 UG






























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:20:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           80           98           80                                     
                                                                                                                                    
  Scheduled Sacrifice                                 13           10           13            9                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8           10            8            9                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (10)         (8)          (9)                                    
      Basophilic Focus                                              1                         1                                     
      Eosinophilic Focus                                            1            1            1                                     
      Eosinophilic Focus, Multiple                                  1                                                               
      Fatty Change, Diffuse                                         1 [1.0]      3 [1.0]      9 [1.7]                               
      Fatty Change, Focal                                           1 [1.0]                                                         
      Hepatodiaphragmatic Nodule                                    1                                                               
      Infiltration Cellular, Histiocyte                                          1 [1.0]                                            
      Inflammation                                     8 [1.0]     10 [1.0]      8 [1.0]      9 [1.1]                               
      Mixed Cell Focus                                 1            1                         3                                     
      Mixed Cell Focus, Multiple                       4            8            2            3                                     
      Pigmentation                                                 10 [1.4]      8 [1.4]      9 [2.1]                               
      Toxic Hepatopathy                                             3 [1.0]                   6 [1.0]                               
      Bile Duct, Fibrosis                                           1 [1.0]                                                         
      Bile Duct, Hyperplasia                                        2 [1.0]                   5 [1.4]                               
      Hepatocyte, Hypertrophy                                      10 [1.0]      8 [1.0]      9 [2.4]                               
      Hepatocyte, Multinucleated                                    3 [1.0]      2 [1.0]      7 [1.1]                               
      Oval Cell, Hyperplasia                                        1 [1.0]                   2 [1.0]                               
   Pancreas                                           (8)          (10)         (8)          (9)                                    
      Acinus, Atrophy                                                                         1 [1.0]                               
      Acinus, Hyperplasia                                                                     1 [2.0]                               
      Acinus, Vacuolization Cytoplasmic                                                       6 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:20:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Cortex                                     (8)          (10)         (8)          (9)                                    
      Degeneration, Cystic                             2 [2.5]      1 [2.0]      1 [2.0]      1 [2.0]                               
      Hyperplasia                                      1 [2.0]      3 [1.7]      1 [1.0]      1 [2.0]                               
      Hypertrophy                                      4 [1.0]      5 [1.4]      5 [1.6]      3 [1.7]                               
      Vacuolization Cytoplasmic                                                               1 [1.0]                               
   Thyroid Gland                                      (8)          (10)         (8)          (9)                                    
      C-Cell, Hyperplasia                              2 [1.5]                                1 [1.0]                               
      Follicular Cell, Hypertrophy                                  7 [1.0]      6 [1.2]      6 [1.2]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (10)         (8)          (9)                                    
      Atrophy                                          7 [4.0]      8 [4.0]      7 [4.0]      8 [4.0]                               
      Cyst                                             1 [2.0]                   1 [2.0]                                            
      Inflammation, Suppurative                                                               1 [1.0]                               
   Uterus                                             (8)          (10)         (8)          (9)                                    
      Inflammation, Suppurative                                                               6 [1.5]                               
      Metaplasia, Squamous                             7 [2.0]      9 [2.3]      7 [3.0]      7 [3.0]                               
      Endometrium, Hyperplasia, Cystic                 5 [1.8]                                2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                    (9)                                    
      Pigmentation                                     8 [1.5]                                9 [1.8]                               
   Thymus                                             (8)          (10)         (8)          (9)                                    
      Atrophy                                          5 [1.2]     10 [2.3]      8 [2.4]      9 [2.1]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (2)          (5)          (9)                                    
      Cyst                                             1 [1.0]                   2 [3.0]                                            
      Hyperplasia                                      4 [1.0]                   1 [1.0]                                            
      Inflammation, Granulomatous                                                1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 14:20:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (10)         (8)          (9)                                    
      Infiltration Cellular, Histiocyte                4 [1.3]                   2 [1.0]      4 [1.0]                               
      Alveolar Epithelium, Hyperplasia                              1 [2.0]                                                         
      Alveolar Epithelium, Metaplasia, Bronchiolar                  3 [1.0]      1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                                          (1)                                                              
      Mineralization                                                1 [2.0]                                                         
      Nephropathy                                                   1 [2.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
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