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TDMS Study 89010-01 Pathology Tables

NTP Experiment-Test: 89010-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04
Route: DOSED WATER                                                                                                Time: 10:29:54




       Facility:  Southern Research Institute

       Chemical CAS #:  PESTFERTMIX3

       Lock Date:  09/08/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89010-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:29:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          40           40           40           40           40                        
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           30           30           30           30                        
                                                                                                                                    
  Animals Examined Microscopically                    20           20           20           20           20                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (20)         (20)         (20)         (20)         (20)                      
      Parasite Metazoan                                                          1 (5%)       1 (5%)                                
   Intestine Large, Rectum                            (20)         (20)         (19)         (20)         (20)                      
      Parasite Metazoan                                2 (10%)      2 (10%)      3 (16%)      2 (10%)      1 (5%)                   
   Intestine Small, Ileum                             (20)         (20)         (20)         (20)         (20)                      
      Lymphoid Tissue, Inflammation, Chronic                                                               1 (5%)                   
   Liver                                              (20)         (20)         (20)         (20)         (20)                      
      Fibrosis, Focal                                                                         1 (5%)                                
      Hepatodiaphragmatic Nodule                       1 (5%)       3 (15%)      1 (5%)       3 (15%)      3 (15%)                  
      Necrosis, Focal                                                                                      1 (5%)                   
      Serosa, Inflammation, Chronic                                 1 (5%)                                                          
   Mesentery                                                                                 (1)                                    
      Fat, Necrosis                                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (20)         (20)         (20)         (20)         (20)                      
      Accessory Adrenal Cortical Nodule                2 (10%)                                                                      
      Angiectasis                                                                                          1 (5%)                   
      Angiectasis, Focal                                                                                   1 (5%)                   
      Hyperplasia, Focal                                                                                   1 (5%)                   
   Adrenal Medulla                                    (20)         (20)         (20)         (20)         (20)                      
      Angiectasis                                                                                          1 (5%)                   
   Pituitary Gland                                    (19)         (20)         (20)         (20)         (20)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:29:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst                                                          1 (5%)       1 (5%)       2 (10%)                               
      Pars Distalis, Hyperplasia, Focal                             1 (5%)                                                          
   Thyroid Gland                                      (20)         (20)         (20)         (20)         (20)                      
      Ultimobranchial Cyst                             3 (15%)      2 (10%)      2 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (20)         (20)         (20)         (20)         (20)                      
      Cyst                                             1 (5%)                                              1 (5%)                   
   Uterus                                             (20)         (20)         (20)         (20)         (20)                      
      Hydrometra                                       4 (20%)      4 (20%)      6 (30%)      4 (20%)      5 (25%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (20)         (20)         (20)         (20)         (20)                      
      Hemorrhage                                                                                           1 (5%)                   
   Spleen                                             (20)         (20)         (20)         (20)         (20)                      
      Congestion                                                    1 (5%)                                                          
      Fibrosis, Focal                                                                                      1 (5%)                   
   Thymus                                             (20)         (19)         (20)         (19)         (20)                      
      Hemorrhage                                       1 (5%)       1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (20)         (20)         (20)         (20)         (20)                      
      Nipple, Cyst Epithelial Inclusion                             1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:29:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (20)         (20)         (20)                      
      Infiltration Cellular, Focal, Lymphocyte                                                             1 (5%)                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:29:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          40           40           40           40           40                        
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           30           30           30           30                        
                                                                                                                                    
  Animals Examined Microscopically                    20           20           20           20           20                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (20)         (20)         (20)         (20)         (20)                      
      Parasite Metazoan                                3 (15%)      1 (5%)       3 (15%)      1 (5%)                                
   Liver                                              (20)         (20)         (20)         (20)         (20)                      
      Hepatodiaphragmatic Nodule                                                 1 (5%)       2 (10%)      2 (10%)                  
   Mesentery                                                                    (1)                                                 
      Fat, Necrosis                                                              1 (100%)                                           
   Pancreas                                           (20)         (20)         (20)         (20)         (20)                      
      Atrophy, Focal                                   2 (10%)      2 (10%)                                3 (15%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (20)         (20)         (20)         (20)                      
      Artery, Inflammation, Chronic                    1 (5%)                                              2 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (20)         (20)         (20)         (20)         (20)                      
      Accessory Adrenal Cortical Nodule                             1 (5%)                                                          
   Pituitary Gland                                    (20)         (20)         (20)         (20)         (18)                      
      Angiectasis                                                                             1 (5%)                                
      Cyst                                             4 (20%)      1 (5%)                                                          
      Pars Distalis, Hyperplasia, Focal                                                                    2 (11%)                  
   Thyroid Gland                                      (20)         (20)         (20)         (20)         (20)                      
      Ultimobranchial Cyst                                          2 (10%)      1 (5%)       3 (15%)      1 (5%)                   
      Follicular Cell, Hyperplasia                                  1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:29:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (20)         (20)         (20)         (20)         (20)                      
      Inflammation, Chronic                            3 (15%)      3 (15%)      1 (5%)       1 (5%)       3 (15%)                  
   Prostate                                           (20)         (20)         (20)         (20)         (20)                      
      Inflammation, Suppurative                        4 (20%)      5 (25%)      5 (25%)      6 (30%)      3 (15%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                   (1)                                                 
      Mediastinal, Hemorrhage                                                    1 (100%)                                           
   Lymph Node, Mandibular                             (20)         (20)         (20)         (20)         (20)                      
      Hyperplasia                                                                             1 (5%)                                
   Thymus                                             (20)         (20)         (20)         (20)         (20)                      
      Hemorrhage                                                    1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (20)         (20)         (20)         (20)         (20)                      
      Inflammation, Suppurative                                                                            1 (5%)                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:29:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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