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TDMS Study 96022-02 Pathology Tables

                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 06/10/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:02:55       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      TEF EVALUATION (PCB MIXTURE;PCB 126/P                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Degeneration Cystic                                                                          
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
                                       Inflammation                                                                                 
                                       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Blood Vessel: Aorta, Adventitia        Hemorrhage                                                                                   
                                       Inflammation                                                                                 
Bone Marrow                            Atrophy                                                                                      
                                       Hyperplasia                                                                                  
Brain                                  Hemorrhage                                                                                   
Clitoral Gland                         Inflammation                                                                                 
Clitoral Gland: Duct                   Cyst                                                                                         
Esophagus: Muscularis                  Inflammation                                                                                 
Harderian Gland                        Inflammation                                                                                 
Heart                                  Cardiomyopathy                                                                               
Heart: Coronary Artery                 Inflammation Chronic                                                                         
Heart: Epicardium                      Inflammation                                                                                 
Heart: Myocardium                      Hemorrhage                                                                                   
                                       Necrosis                                                                                     
Intestine Large, Cecum                 Edema                                                                                        
                                       Inflammation                                                                                 
Intestine Large, Colon                 Parasite Metazoan                                                                            
Intestine Large, Rectum: Artery        Inflammation Chronic                                                                         
Kidney                                 Mineralization                                                                               
                                       Nephropathy                                                                                  
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Fatty Change Focal                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Metaplasia                                                                                   
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Cyst                                                                                         
                                       Fibrosis                                                                                     
                                       Hyperplasia                                                                                  
Liver: Centrilobular                   Degeneration                                                                                 
                                       Fibrosis                                                                                     
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 06/10/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:02:55       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
Liver: Hepatocyte                      Glandular Structures                                                                         
                                       Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Hemorrhage                                                                                   
                                       Infiltration Cellular Histiocyte                                                             
                                       Inflammation                                                                                 
                                       Inflammation Granulomatous                                                                   
                                       Keratin Cyst                                                                                 
                                       Metaplasia                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia Bronchiolar                                                                       
Lung: Serosa                           Fibrosis                                                                                     
Lymph Node, Mandibular                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node, Mesenteric                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Mediastinal                Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Lymph Node: Pancreatic                 Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Renal                      Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Mammary Gland                          Hyperplasia                                                                                  
Mesentery: Artery                      Inflammation Chronic                                                                         
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Inflammation                                                                                 
Nose: Olfactory Epithelium             Metaplasia                                                                                   
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Oral Mucosa: Gingival                  Hyperplasia                                                                                  
Ovary                                  Atrophy                                                                                      
                                       Cyst                                                                                         
Pancreas                               Edema                                                                                        
                                       Hemorrhage                                                                                   
                                       Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                       Vacuolization Cytoplasmic                                                                    
Pancreas: Artery                       Inflammation Chronic                                                                         
Pituitary Gland                        Angiectasis                                                                                  
                                       Cyst                                                                                         
                                       Cytoplasmic Alteration                                                                       
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Spleen: Lymphoid Follicle              Atrophy                                                                                      
Spleen: Red Pulp                       Atrophy                                                                                      
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Mineralization                                                                               
                                       Ulcer                                                                                        
Stomach, Glandular                     Erosion                                                                                      
                                       Hemorrhage                                                                                   
                                       Mineralization                                                                               
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 06/10/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:02:55       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
Thymus                                 Atrophy                                                                                      
Thyroid Gland                          Infiltration Cellular Lymphoid                                                               
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Uterus                                 Inflammation                                                                                 
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P                    
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              21/50 (42%)                                       6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              21/28.18                                          6/14.36                      | 
|POLY-3 PERCENT (g) |                              74.5%                                             41.8%                        | 
|TERMINAL (d)       |                              9/10 (90%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              232                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.485                      | 
|POLY 3             |                                                                                P=0.048N*                    | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.754N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.012N*                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/50 (24%)                                       40/65 (62%)                  | 
|POLY-3 RATE (b)    |                              12/30.21                                          40/41.82                     | 
|POLY-3 PERCENT (g) |                              39.7%                                             95.7%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              9/50 (18%)                                        2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              9/22.95                                           2/10.85                      | 
|POLY-3 PERCENT (g) |                              39.2%                                             18.4%                        | 
|TERMINAL (d)       |                              4/10 (40%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              504                                               336                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.338                      | 
|POLY 3             |                                                                                P=0.339N                     | 
|POLY 1.5           |                                                                                P=0.053N                     | 
|POLY 6             |                                                                                P=0.924N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.478N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.008N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/50 (20%)                                       5/65 (8%)                    | 
|POLY-3 RATE (b)    |                              10/25.67                                          5/13.17                      | 
|POLY-3 PERCENT (g) |                              39.0%                                             38.0%                        | 
|TERMINAL (d)       |                              4/10 (40%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              258                                               321                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.334                      | 
|POLY 3             |                                                                                P=0.697N                     | 
|POLY 1.5           |                                                                                P=0.260N                     | 
|POLY 6             |                                                                                P=0.537                      | 
|LOGISTIC REGRESSION|                                                                                P=0.258N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.048N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              29/50 (58%)                                       27/65 (42%)                  | 
|POLY-3 RATE (b)    |                              29/31.75                                          27/31.15                     | 
|POLY-3 PERCENT (g) |                              91.3%                                             86.7%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              230                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.390N                     | 
|POLY 1.5           |                                                                                P=0.121N                     | 
|POLY 6             |                                                                                P=0.824                      | 
|LOGISTIC REGRESSION|                                                                                P=0.465                      | 
|COCH-ARM / FISHERS |                                                                                P=0.059N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              2/22.11                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              9.1%                                              0.0%                         | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              279                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.443N                     | 
|POLY 3             |                                                                                P=0.737N                     | 
|POLY 1.5           |                                                                                P=0.356N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.250N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.187N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              2/22.01                                           4/13.13                      | 
|POLY-3 PERCENT (g) |                              9.1%                                              30.5%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              267                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.274                      | 
|POLY 3             |                                                                                P=0.190                      | 
|POLY 1.5           |                                                                                P=0.286                      | 
|POLY 6             |                                                                                P=0.159                      | 
|LOGISTIC REGRESSION|                                                                                P=0.603                      | 
|COCH-ARM / FISHERS |                                                                                P=0.471                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              16/50 (32%)                                       12/65 (18%)                  | 
|POLY-3 RATE (b)    |                              16/26.74                                          12/18.81                     | 
|POLY-3 PERCENT (g) |                              59.9%                                             63.8%                        | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.006 **                   | 
|POLY 3             |                                                                                P=0.558                      | 
|POLY 1.5           |                                                                                P=0.316N                     | 
|POLY 6             |                                                                                P=0.216                      | 
|LOGISTIC REGRESSION|                                                                                P=0.572N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.073N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/49 (16%)                                        0/64 (0%)                    | 
|POLY-3 RATE (b)    |                              8/23.03                                           0/9.22                       | 
|POLY-3 PERCENT (g) |                              34.7%                                             0.0%                         | 
|TERMINAL (d)       |                              3/9 (33%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.247N                     | 
|POLY 3             |                                                                                P=0.188N                     | 
|POLY 1.5           |                                                                                P=0.012N*                    | 
|POLY 6             |                                                                                P=0.979N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.026N*                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta, Adventitia                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         1/66 (2%)                    | 
|POLY-3 RATE (b)    |                              2/22.98                                           1/10.26                      | 
|POLY-3 PERCENT (g) |                              8.7%                                              9.8%                         | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              240                                               294                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.412N                     | 
|POLY 3             |                                                                                P=0.848                      | 
|POLY 1.5           |                                                                                P=0.631N                     | 
|POLY 6             |                                                                                P=0.976                      | 
|LOGISTIC REGRESSION|                                                                                P=0.264N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.396N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta, Adventitia                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              2/22.99                                           2/11.08                      | 
|POLY-3 PERCENT (g) |                              8.7%                                              18.1%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              240                                               294                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.654N                     | 
|POLY 3             |                                                                                P=0.592                      | 
|POLY 1.5           |                                                                                P=0.645                      | 
|POLY 6             |                                                                                P=0.745                      | 
|LOGISTIC REGRESSION|                                                                                P=0.452N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.580N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/50 (8%)                                         12/66 (18%)                  | 
|POLY-3 RATE (b)    |                              4/24.94                                           12/20.74                     | 
|POLY-3 PERCENT (g) |                              16.0%                                             57.9%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.102                      | 
|POLY 3             |                                                                                P=0.002 **                   | 
|POLY 1.5           |                                                                                P=0.016 *                    | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.275                      | 
|COCH-ARM / FISHERS |                                                                                P=0.095                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/50 (80%)                                       49/66 (74%)                  | 
|POLY-3 RATE (b)    |                              40/46.05                                          49/50.11                     | 
|POLY-3 PERCENT (g) |                              86.9%                                             97.8%                        | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.032 *                    | 
|POLY 1.5           |                                                                                P=0.179                      | 
|POLY 6             |                                                                                P=0.014 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.432N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.309N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/50 (16%)                                        14/66 (21%)                  | 
|POLY-3 RATE (b)    |                              8/28.75                                           14/22.64                     | 
|POLY-3 PERCENT (g) |                              27.8%                                             61.8%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.307                      | 
|POLY 3             |                                                                                P=0.011 *                    | 
|POLY 1.5           |                                                                                P=0.070                      | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.547N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.322                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              30/50 (60%)                                       31/66 (47%)                  | 
|POLY-3 RATE (b)    |                              30/33.33                                          31/35.89                     | 
|POLY-3 PERCENT (g) |                              90.0%                                             86.4%                        | 
|TERMINAL (d)       |                              9/10 (90%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.435N                     | 
|POLY 1.5           |                                                                                P=0.144N                     | 
|POLY 6             |                                                                                P=0.592                      | 
|LOGISTIC REGRESSION|                                                                                P=0.517N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.114N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/50 (80%)                                       61/66 (92%)                  | 
|POLY-3 RATE (b)    |                              40/43.50                                          61/61.31                     | 
|POLY-3 PERCENT (g) |                              92.0%                                             99.5%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.019 *                    | 
|POLY 1.5           |                                                                                P=0.013 *                    | 
|POLY 6             |                                                                                P=0.053                      | 
|LOGISTIC REGRESSION|                                                                                P=0.023 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.045 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/50 (0%)                                         2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              0/21.06                                           2/10.61                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.9%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               254                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.055                      | 
|POLY 3             |                                                                                P=0.277                      | 
|POLY 1.5           |                                                                                P=0.227                      | 
|POLY 6             |                                                                                P=0.642                      | 
|LOGISTIC REGRESSION|                                                                                P=0.221                      | 
|COCH-ARM / FISHERS |                                                                                P=0.322                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/50 (24%)                                       9/66 (14%)                   | 
|POLY-3 RATE (b)    |                              12/26.40                                          9/16.65                      | 
|POLY-3 PERCENT (g) |                              45.5%                                             54.1%                        | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.121                      | 
|POLY 3             |                                                                                P=0.459                      | 
|POLY 1.5           |                                                                                P=0.452N                     | 
|POLY 6             |                                                                                P=0.184                      | 
|LOGISTIC REGRESSION|                                                                                P=0.322N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.117N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              15/50 (30%)                                       19/65 (29%)                  | 
|POLY-3 RATE (b)    |                              15/28.08                                          19/24.56                     | 
|POLY-3 PERCENT (g) |                              53.4%                                             77.4%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               237                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.042 *                    | 
|POLY 1.5           |                                                                                P=0.211                      | 
|POLY 6             |                                                                                P=0.007 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.254                      | 
|COCH-ARM / FISHERS |                                                                                P=0.545N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Coronary Artery                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/50 (12%)                                        9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              6/24.90                                           9/16.16                      | 
|POLY-3 PERCENT (g) |                              24.1%                                             55.7%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              273                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.015 *                    | 
|POLY 3             |                                                                                P=0.054                      | 
|POLY 1.5           |                                                                                P=0.185                      | 
|POLY 6             |                                                                                P=0.015 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.333                      | 
|COCH-ARM / FISHERS |                                                                                P=0.499                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Epicardium                                                                                                                | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              1/21.78                                           6/13.78                      | 
|POLY-3 PERCENT (g) |                              4.6%                                              43.5%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              474                                               362                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.005 **                   | 
|POLY 3             |                                                                                P=0.014 *                    | 
|POLY 1.5           |                                                                                P=0.035 *                    | 
|POLY 6             |                                                                                P=0.007 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.050                      | 
|COCH-ARM / FISHERS |                                                                                P=0.110                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         3/65 (5%)                    | 
|POLY-3 RATE (b)    |                              1/22.01                                           3/12.08                      | 
|POLY-3 PERCENT (g) |                              4.5%                                              24.8%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              258                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.393                      | 
|POLY 3             |                                                                                P=0.219                      | 
|POLY 1.5           |                                                                                P=0.264                      | 
|POLY 6             |                                                                                P=0.284                      | 
|LOGISTIC REGRESSION|                                                                                P=0.550                      | 
|COCH-ARM / FISHERS |                                                                                P=0.414                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/50 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/21.06                                           2/11.19                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              17.9%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.297                      | 
|POLY 3             |                                                                                P=0.263                      | 
|POLY 1.5           |                                                                                P=0.227                      | 
|POLY 6             |                                                                                P=0.556                      | 
|LOGISTIC REGRESSION|                                                                                P=0.403                      | 
|COCH-ARM / FISHERS |                                                                                P=0.317                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              1/22.03                                           2/11.19                      | 
|POLY-3 PERCENT (g) |                              4.5%                                              17.9%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              232                                               254                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.596                      | 
|POLY 3             |                                                                                P=0.453                      | 
|POLY 1.5           |                                                                                P=0.466                      | 
|POLY 6             |                                                                                P=0.667                      | 
|LOGISTIC REGRESSION|                                                                                P=0.735N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.598                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              1/22.03                                           2/11.20                      | 
|POLY-3 PERCENT (g) |                              4.5%                                              17.9%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              232                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.600                      | 
|POLY 3             |                                                                                P=0.453                      | 
|POLY 1.5           |                                                                                P=0.466                      | 
|POLY 6             |                                                                                P=0.667                      | 
|LOGISTIC REGRESSION|                                                                                P=0.732N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.598                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              1/21.06                                           2/11.13                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              18.0%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           236                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.254                      | 
|POLY 3             |                                                                                P=0.449                      | 
|POLY 1.5           |                                                                                P=0.469                      | 
|POLY 6             |                                                                                P=0.638                      | 
|LOGISTIC REGRESSION|                                                                                P=0.528                      | 
|COCH-ARM / FISHERS |                                                                                P=0.598                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum: Artery                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/50 (8%)                                         0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              4/21.71                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              18.4%                                             0.0%                         | 
|TERMINAL (d)       |                              2/10 (20%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              607                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.901N                     | 
|POLY 3             |                                                                                P=0.443N                     | 
|POLY 1.5           |                                                                                P=0.112N                     | 
|POLY 6             |                                                                                P=0.994N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.604N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.032N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              32/50 (64%)                                       37/65 (57%)                  | 
|POLY-3 RATE (b)    |                              32/39.76                                          37/39.76                     | 
|POLY-3 PERCENT (g) |                              80.5%                                             93.1%                        | 
|TERMINAL (d)       |                              7/10 (70%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.050                      | 
|POLY 1.5           |                                                                                P=0.266                      | 
|POLY 6             |                                                                                P=0.016 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.484N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.283N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              34/50 (68%)                                       43/65 (66%)                  | 
|POLY-3 RATE (b)    |                              34/34.66                                          43/44.50                     | 
|POLY-3 PERCENT (g) |                              98.1%                                             96.6%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.742N                     | 
|POLY 1.5           |                                                                                P=0.456N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.123                      | 
|COCH-ARM / FISHERS |                                                                                P=0.498N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/50 (8%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              4/21.49                                           2/10.57                      | 
|POLY-3 PERCENT (g) |                              18.6%                                             18.9%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              601                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.107                      | 
|POLY 3             |                                                                                P=0.776                      | 
|POLY 1.5           |                                                                                P=0.459N                     | 
|POLY 6             |                                                                                P=0.822                      | 
|LOGISTIC REGRESSION|                                                                                P=0.493                      | 
|COCH-ARM / FISHERS |                                                                                P=0.225N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/50 (10%)                                        0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              5/21.73                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              23.0%                                             0.0%                         | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              601                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.916N                     | 
|POLY 3             |                                                                                P=0.346N                     | 
|POLY 1.5           |                                                                                P=0.065N                     | 
|POLY 6             |                                                                                P=0.988N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.599N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.014N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              27/50 (54%)                                       29/65 (45%)                  | 
|POLY-3 RATE (b)    |                              27/33.72                                          29/31.95                     | 
|POLY-3 PERCENT (g) |                              80.1%                                             90.8%                        | 
|TERMINAL (d)       |                              8/10 (80%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.133                      | 
|POLY 1.5           |                                                                                P=0.483                      | 
|POLY 6             |                                                                                P=0.043 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.328                      | 
|COCH-ARM / FISHERS |                                                                                P=0.209N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              15/50 (30%)                                       10/65 (15%)                  | 
|POLY-3 RATE (b)    |                              15/28.06                                          10/18.34                     | 
|POLY-3 PERCENT (g) |                              53.5%                                             54.5%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.186                      | 
|POLY 3             |                                                                                P=0.642                      | 
|POLY 1.5           |                                                                                P=0.243N                     | 
|POLY 6             |                                                                                P=0.276                      | 
|LOGISTIC REGRESSION|                                                                                P=0.114N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.049N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              35/50 (70%)                                       56/65 (86%)                  | 
|POLY-3 RATE (b)    |                              35/43.37                                          56/57.00                     | 
|POLY-3 PERCENT (g) |                              80.7%                                             98.3%                        | 
|TERMINAL (d)       |                              7/10 (70%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.106                      | 
|COCH-ARM / FISHERS |                                                                                P=0.030 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              14/50 (28%)                                       6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              14/24.02                                          6/13.82                      | 
|POLY-3 PERCENT (g) |                              58.3%                                             43.4%                        | 
|TERMINAL (d)       |                              7/10 (70%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              282                                               329                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.034 *                    | 
|POLY 3             |                                                                                P=0.354N                     | 
|POLY 1.5           |                                                                                P=0.057N                     | 
|POLY 6             |                                                                                P=0.770                      | 
|LOGISTIC REGRESSION|                                                                                P=0.627                      | 
|COCH-ARM / FISHERS |                                                                                P=0.009N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              22/50 (44%)                                       11/65 (17%)                  | 
|POLY-3 RATE (b)    |                              22/29.47                                          11/17.99                     | 
|POLY-3 PERCENT (g) |                              74.6%                                             61.1%                        | 
|TERMINAL (d)       |                              8/10 (80%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.071                      | 
|POLY 3             |                                                                                P=0.281N                     | 
|POLY 1.5           |                                                                                P=0.015N*                    | 
|POLY 6             |                                                                                P=0.656                      | 
|LOGISTIC REGRESSION|                                                                                P=0.080N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              34/50 (68%)                                       61/65 (94%)                  | 
|POLY-3 RATE (b)    |                              34/44.64                                          61/61.04                     | 
|POLY-3 PERCENT (g) |                              76.2%                                             99.9%                        | 
|TERMINAL (d)       |                              4/10 (40%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.008 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              48/50 (96%)                                       64/65 (98%)                  | 
|POLY-3 RATE (b)    |                              48/48.82                                          64/64.15                     | 
|POLY-3 PERCENT (g) |                              98.3%                                             99.8%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.532                      | 
|POLY 1.5           |                                                                                P=0.464                      | 
|POLY 6             |                                                                                P=0.667                      | 
|LOGISTIC REGRESSION|                                                                                P=0.490                      | 
|COCH-ARM / FISHERS |                                                                                P=0.402                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              2/22.97                                           4/11.99                      | 
|POLY-3 PERCENT (g) |                              8.7%                                              33.4%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              232                                               338                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.130                      | 
|POLY 3             |                                                                                P=0.177                      | 
|POLY 1.5           |                                                                                P=0.261                      | 
|POLY 6             |                                                                                P=0.174                      | 
|LOGISTIC REGRESSION|                                                                                P=0.451                      | 
|COCH-ARM / FISHERS |                                                                                P=0.471                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              20/50 (40%)                                       3/65 (5%)                    | 
|POLY-3 RATE (b)    |                              20/26.46                                          3/11.13                      | 
|POLY-3 PERCENT (g) |                              75.6%                                             27.0%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              282                                               429                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.523                      | 
|POLY 3             |                                                                                P=0.016N*                    | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.903N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.046N*                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/50 (12%)                                        27/65 (42%)                  | 
|POLY-3 RATE (b)    |                              6/25.40                                           27/31.21                     | 
|POLY-3 PERCENT (g) |                              23.6%                                             86.5%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              50/50 (100%)                                      60/65 (92%)                  | 
|POLY-3 RATE (b)    |                              50/50.00                                          60/60.56                     | 
|POLY-3 PERCENT (g) |                              100.0%                                            99.1%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.890N                     | 
|POLY 1.5           |                                                                                P=0.293N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.109N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.054N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              50/50 (100%)                                      64/65 (98%)                  | 
|POLY-3 RATE (b)    |                              50/50.00                                          64/64.00                     | 
|POLY-3 PERCENT (g) |                              100.0%                                            100.0%                       | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=1.000N                     | 
|POLY 1.5           |                                                                                P=1.000N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                P=0.565N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              21/50 (42%)                                       14/65 (22%)                  | 
|POLY-3 RATE (b)    |                              21/25.42                                          14/19.17                     | 
|POLY-3 PERCENT (g) |                              82.6%                                             73.0%                        | 
|TERMINAL (d)       |                              9/10 (90%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              474                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.325N                     | 
|POLY 1.5           |                                                                                P=0.050N                     | 
|POLY 6             |                                                                                P=0.780                      | 
|LOGISTIC REGRESSION|                                                                                P=0.091                      | 
|COCH-ARM / FISHERS |                                                                                P=0.016N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/50 (24%)                                       4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              12/24.42                                          4/12.37                      | 
|POLY-3 PERCENT (g) |                              49.2%                                             32.3%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              383                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.159                      | 
|POLY 3             |                                                                                P=0.369N                     | 
|POLY 1.5           |                                                                                P=0.050N                     | 
|POLY 6             |                                                                                P=0.800                      | 
|LOGISTIC REGRESSION|                                                                                P=0.346N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.007N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              37/50 (74%)                                       60/65 (92%)                  | 
|POLY-3 RATE (b)    |                              37/44.10                                          60/60.13                     | 
|POLY-3 PERCENT (g) |                              83.9%                                             99.8%                        | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P=0.002 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.013 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.008 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/50 (12%)                                        8/65 (12%)                   | 
|POLY-3 RATE (b)    |                              6/25.86                                           8/16.92                      | 
|POLY-3 PERCENT (g) |                              23.2%                                             47.3%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.462                      | 
|POLY 3             |                                                                                P=0.119                      | 
|POLY 1.5           |                                                                                P=0.291                      | 
|POLY 6             |                                                                                P=0.040 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.345N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.628N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              43/50 (86%)                                       57/65 (88%)                  | 
|POLY-3 RATE (b)    |                              43/50.00                                          57/59.02                     | 
|POLY-3 PERCENT (g) |                              86.0%                                             96.6%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.034 *                    | 
|POLY 1.5           |                                                                                P=0.103                      | 
|POLY 6             |                                                                                P=0.010 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.070N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.501                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Glandular Structures                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              9/50 (18%)                                        25/65 (38%)                  | 
|POLY-3 RATE (b)    |                              9/29.71                                           25/31.26                     | 
|POLY-3 PERCENT (g) |                              30.3%                                             80.0%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.005 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.129                      | 
|COCH-ARM / FISHERS |                                                                                P=0.014 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              36/50 (72%)                                       65/65 (100%)                 | 
|POLY-3 RATE (b)    |                              36/45.73                                          65/65.00                     | 
|POLY-3 PERCENT (g) |                              78.7%                                             100.0%                       | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.005 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              38/50 (76%)                                       48/65 (74%)                  | 
|POLY-3 RATE (b)    |                              38/44.81                                          48/50.32                     | 
|POLY-3 PERCENT (g) |                              84.8%                                             95.4%                        | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.046 *                    | 
|POLY 1.5           |                                                                                P=0.194                      | 
|POLY 6             |                                                                                P=0.014 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.356N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.483N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              43/50 (86%)                                       62/65 (95%)                  | 
|POLY-3 RATE (b)    |                              43/48.43                                          62/62.03                     | 
|POLY-3 PERCENT (g) |                              88.8%                                             100.0%                       | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.008 **                   | 
|POLY 1.5           |                                                                                P=0.006 **                   | 
|POLY 6             |                                                                                P=0.010 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.183                      | 
|COCH-ARM / FISHERS |                                                                                P=0.076                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              42/50 (84%)                                       58/65 (89%)                  | 
|POLY-3 RATE (b)    |                              42/48.26                                          58/58.27                     | 
|POLY-3 PERCENT (g) |                              87.0%                                             99.5%                        | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.005 **                   | 
|POLY 1.5           |                                                                                P=0.010 *                    | 
|POLY 6             |                                                                                P=0.007 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.443                      | 
|COCH-ARM / FISHERS |                                                                                P=0.291                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/50 (6%)                                         4/66 (6%)                    | 
|POLY-3 RATE (b)    |                              3/23.69                                           4/12.86                      | 
|POLY-3 PERCENT (g) |                              12.7%                                             31.1%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.440                      | 
|POLY 3             |                                                                                P=0.285                      | 
|POLY 1.5           |                                                                                P=0.419                      | 
|POLY 6             |                                                                                P=0.247                      | 
|LOGISTIC REGRESSION|                                                                                P=0.524N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.651N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              24/50 (48%)                                       33/66 (50%)                  | 
|POLY-3 RATE (b)    |                              24/32.50                                          33/37.16                     | 
|POLY-3 PERCENT (g) |                              73.8%                                             88.8%                        | 
|TERMINAL (d)       |                              6/10 (60%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.054                      | 
|POLY 1.5           |                                                                                P=0.181                      | 
|POLY 6             |                                                                                P=0.016 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.134                      | 
|COCH-ARM / FISHERS |                                                                                P=0.490                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/50 (12%)                                        2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              6/23.16                                           2/11.03                      | 
|POLY-3 PERCENT (g) |                              25.9%                                             18.1%                        | 
|TERMINAL (d)       |                              2/10 (20%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              267                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.601                      | 
|POLY 3             |                                                                                P=0.610N                     | 
|POLY 1.5           |                                                                                P=0.226N                     | 
|POLY 6             |                                                                                P=0.873                      | 
|LOGISTIC REGRESSION|                                                                                P=0.282N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.065N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/50 (8%)                                         0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              4/22.05                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              18.1%                                             0.0%                         | 
|TERMINAL (d)       |                              2/10 (20%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              561                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.793N                     | 
|POLY 3             |                                                                                P=0.455N                     | 
|POLY 1.5           |                                                                                P=0.115N                     | 
|POLY 6             |                                                                                P=0.995N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.396N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.032N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Keratin Cyst                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              9/50 (18%)                                        0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              9/23.33                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              38.6%                                             0.0%                         | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              525                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.664N                     | 
|POLY 3             |                                                                                P=0.145N                     | 
|POLY 1.5           |                                                                                P=0.006N**                   | 
|POLY 6             |                                                                                P=0.977N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.110N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/50 (16%)                                        7/66 (11%)                   | 
|POLY-3 RATE (b)    |                              8/22.72                                           7/14.88                      | 
|POLY-3 PERCENT (g) |                              35.2%                                             47.1%                        | 
|TERMINAL (d)       |                              4/10 (40%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              541                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.006 **                   | 
|POLY 3             |                                                                                P=0.399                      | 
|POLY 1.5           |                                                                                P=0.599N                     | 
|POLY 6             |                                                                                P=0.184                      | 
|LOGISTIC REGRESSION|                                                                                P=0.251                      | 
|COCH-ARM / FISHERS |                                                                                P=0.280N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/50 (10%)                                        4/66 (6%)                    | 
|POLY-3 RATE (b)    |                              5/22.02                                           4/12.41                      | 
|POLY-3 PERCENT (g) |                              22.7%                                             32.2%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              383                                               303                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.054                      | 
|POLY 3             |                                                                                P=0.514                      | 
|POLY 1.5           |                                                                                P=0.622N                     | 
|POLY 6             |                                                                                P=0.396                      | 
|LOGISTIC REGRESSION|                                                                                P=0.377                      | 
|COCH-ARM / FISHERS |                                                                                P=0.329N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              15/50 (30%)                                       8/66 (12%)                   | 
|POLY-3 RATE (b)    |                              15/27.99                                          8/16.09                      | 
|POLY-3 PERCENT (g) |                              53.6%                                             49.7%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.194                      | 
|POLY 3             |                                                                                P=0.597N                     | 
|POLY 1.5           |                                                                                P=0.137N                     | 
|POLY 6             |                                                                                P=0.430                      | 
|LOGISTIC REGRESSION|                                                                                P=0.160N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.016N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Serosa                                                                                                                     | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         8/66 (12%)                   | 
|POLY-3 RATE (b)    |                              1/22.01                                           8/15.93                      | 
|POLY-3 PERCENT (g) |                              4.5%                                              50.2%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              273                                               294                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.006 **                   | 
|POLY 3             |                                                                                P=0.002 **                   | 
|POLY 1.5           |                                                                                P=0.008 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.050                      | 
|COCH-ARM / FISHERS |                                                                                P=0.043 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/49 (22%)                                       1/66 (2%)                    | 
|POLY-3 RATE (b)    |                              11/24.51                                          1/10.25                      | 
|POLY-3 PERCENT (g) |                              44.9%                                             9.8%                         | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              247                                               313                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.513N                     | 
|POLY 3             |                                                                                P=0.160N                     | 
|POLY 1.5           |                                                                                P=0.006N**                   | 
|POLY 6             |                                                                                P=0.935N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.041N*                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/49 (8%)                                         7/66 (11%)                   | 
|POLY-3 RATE (b)    |                              4/24.84                                           7/15.76                      | 
|POLY-3 PERCENT (g) |                              16.1%                                             44.4%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              230                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.365                      | 
|POLY 3             |                                                                                P=0.076                      | 
|POLY 1.5           |                                                                                P=0.188                      | 
|POLY 6             |                                                                                P=0.031 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.540N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.458                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              28/49 (57%)                                       20/66 (30%)                  | 
|POLY-3 RATE (b)    |                              28/32.76                                          20/26.79                     | 
|POLY-3 PERCENT (g) |                              85.5%                                             74.7%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.038 *                    | 
|POLY 3             |                                                                                P=0.176N                     | 
|POLY 1.5           |                                                                                P=0.022N*                    | 
|POLY 6             |                                                                                P=0.770N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.058N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.003N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              1/21.31                                           2/11.14                      | 
|POLY-3 PERCENT (g) |                              4.7%                                              18.0%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              659                                               245                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.268                      | 
|POLY 3             |                                                                                P=0.450                      | 
|POLY 1.5           |                                                                                P=0.468                      | 
|POLY 6             |                                                                                P=0.651                      | 
|LOGISTIC REGRESSION|                                                                                P=0.575                      | 
|COCH-ARM / FISHERS |                                                                                P=0.598                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/50 (20%)                                       14/65 (22%)                  | 
|POLY-3 RATE (b)    |                              10/28.48                                          14/22.13                     | 
|POLY-3 PERCENT (g) |                              35.1%                                             63.3%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.176                      | 
|POLY 3             |                                                                                P=0.037 *                    | 
|POLY 1.5           |                                                                                P=0.164                      | 
|POLY 6             |                                                                                P=0.006 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.373N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.514                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              2/22.10                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              9.1%                                              0.0%                         | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              541                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.753N                     | 
|POLY 3             |                                                                                P=0.736N                     | 
|POLY 1.5           |                                                                                P=0.352N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.388N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.187N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/22 (14%)                                        27/45 (60%)                  | 
|POLY-3 RATE (b)    |                              3/10.39                                           27/29.76                     | 
|POLY-3 PERCENT (g) |                              28.9%                                             90.7%                        | 
|TERMINAL (d)       |                              0/2 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              254                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/22 (50%)                                       25/45 (56%)                  | 
|POLY-3 RATE (b)    |                              11/16.43                                          25/28.50                     | 
|POLY-3 PERCENT (g) |                              67.0%                                             87.7%                        | 
|TERMINAL (d)       |                              0/2 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.034 *                    | 
|POLY 1.5           |                                                                                P=0.126                      | 
|POLY 6             |                                                                                P=0.009 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.473N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.433                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/22 (18%)                                        2/45 (4%)                    | 
|POLY-3 RATE (b)    |                              4/10.38                                           2/7.29                       | 
|POLY-3 PERCENT (g) |                              38.5%                                             27.4%                        | 
|TERMINAL (d)       |                              0/2 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              594                                               611                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.039 *                    | 
|POLY 3             |                                                                                P=0.590N                     | 
|POLY 1.5           |                                                                                P=0.212N                     | 
|POLY 6             |                                                                                P=0.866                      | 
|LOGISTIC REGRESSION|                                                                                P=0.529                      | 
|COCH-ARM / FISHERS |                                                                                P=0.085N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/22 (0%)                                         2/45 (4%)                    | 
|POLY-3 RATE (b)    |                              0/8.85                                            2/8.07                       | 
|POLY-3 PERCENT (g) |                              0.0%                                              24.8%                        | 
|TERMINAL (d)       |                              0/2 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.087                      | 
|POLY 3             |                                                                                P=0.219                      | 
|POLY 1.5           |                                                                                P=0.240                      | 
|POLY 6             |                                                                                P=0.236                      | 
|LOGISTIC REGRESSION|                                                                                P=0.346                      | 
|COCH-ARM / FISHERS |                                                                                P=0.448                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/22 (14%)                                        4/45 (9%)                    | 
|POLY-3 RATE (b)    |                              3/11.01                                           4/10.12                      | 
|POLY-3 PERCENT (g) |                              27.3%                                             39.5%                        | 
|TERMINAL (d)       |                              0/2 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              230                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.375                      | 
|POLY 3             |                                                                                P=0.457                      | 
|POLY 1.5           |                                                                                P=0.621                      | 
|POLY 6             |                                                                                P=0.326                      | 
|LOGISTIC REGRESSION|                                                                                P=0.329N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.417N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/22 (14%)                                        3/45 (7%)                    | 
|POLY-3 RATE (b)    |                              3/11.01                                           3/8.86                       | 
|POLY-3 PERCENT (g) |                              27.3%                                             33.9%                        | 
|TERMINAL (d)       |                              0/2 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              230                                               342                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.354                      | 
|POLY 3             |                                                                                P=0.612                      | 
|POLY 1.5           |                                                                                P=0.567N                     | 
|POLY 6             |                                                                                P=0.526                      | 
|LOGISTIC REGRESSION|                                                                                P=0.363N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.304N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/22 (9%)                                         0/45 (0%)                    | 
|POLY-3 RATE (b)    |                              2/9.18                                            0/6.56                       | 
|POLY-3 PERCENT (g) |                              21.8%                                             0.0%                         | 
|TERMINAL (d)       |                              1/2 (50%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              636                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.970N                     | 
|POLY 3             |                                                                                P=0.414N                     | 
|POLY 1.5           |                                                                                P=0.151N                     | 
|POLY 6             |                                                                                P=0.952N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.808N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.104N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/22 (14%)                                        2/45 (4%)                    | 
|POLY-3 RATE (b)    |                              3/9.93                                            2/7.54                       | 
|POLY-3 PERCENT (g) |                              30.2%                                             26.5%                        | 
|TERMINAL (d)       |                              0/2 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              601                                               545                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.030 *                    | 
|POLY 3             |                                                                                P=0.699N                     | 
|POLY 1.5           |                                                                                P=0.371N                     | 
|POLY 6             |                                                                                P=0.780                      | 
|LOGISTIC REGRESSION|                                                                                P=0.479                      | 
|COCH-ARM / FISHERS |                                                                                P=0.195N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/50 (22%)                                       0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              11/23.96                                          0/9.33                       | 
|POLY-3 PERCENT (g) |                              45.9%                                             0.0%                         | 
|TERMINAL (d)       |                              4/10 (40%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              282                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.276N                     | 
|POLY 3             |                                                                                P=0.087N                     | 
|POLY 1.5           |                                                                                P=0.002N**                   | 
|POLY 6             |                                                                                P=0.973N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.032N*                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              7/43 (16%)                                        3/63 (5%)                    | 
|POLY-3 RATE (b)    |                              7/21.52                                           3/11.22                      | 
|POLY-3 PERCENT (g) |                              32.5%                                             26.7%                        | 
|TERMINAL (d)       |                              1/9 (11%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              451                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.270                      | 
|POLY 3             |                                                                                P=0.631N                     | 
|POLY 1.5           |                                                                                P=0.207N                     | 
|POLY 6             |                                                                                P=0.746                      | 
|LOGISTIC REGRESSION|                                                                                P=0.383N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.050N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/43 (0%)                                         3/63 (5%)                    | 
|POLY-3 RATE (b)    |                              0/18.60                                           3/11.49                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              26.1%                        | 
|TERMINAL (d)       |                              0/9 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.036 *                    | 
|POLY 3             |                                                                                P=0.096                      | 
|POLY 1.5           |                                                                                P=0.108                      | 
|POLY 6             |                                                                                P=0.157                      | 
|LOGISTIC REGRESSION|                                                                                P=0.175                      | 
|COCH-ARM / FISHERS |                                                                                P=0.206                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/50 (22%)                                       11/66 (17%)                  | 
|POLY-3 RATE (b)    |                              11/25.60                                          11/17.92                     | 
|POLY-3 PERCENT (g) |                              43.0%                                             61.4%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.002 **                   | 
|POLY 3             |                                                                                P=0.203                      | 
|POLY 1.5           |                                                                                P=0.511                      | 
|POLY 6             |                                                                                P=0.059                      | 
|LOGISTIC REGRESSION|                                                                                P=0.318                      | 
|COCH-ARM / FISHERS |                                                                                P=0.312N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/50 (10%)                                        1/66 (2%)                    | 
|POLY-3 RATE (b)    |                              5/22.14                                           1/10.02                      | 
|POLY-3 PERCENT (g) |                              22.6%                                             10.0%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              593                                               491                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.448                      | 
|POLY 3             |                                                                                P=0.544N                     | 
|POLY 1.5           |                                                                                P=0.176N                     | 
|POLY 6             |                                                                                P=0.975                      | 
|LOGISTIC REGRESSION|                                                                                P=0.680N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.052N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/50 (20%)                                       9/66 (14%)                   | 
|POLY-3 RATE (b)    |                              10/24.54                                          9/16.16                      | 
|POLY-3 PERCENT (g) |                              40.7%                                             55.7%                        | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              474                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.002 **                   | 
|POLY 3             |                                                                                P=0.307                      | 
|POLY 1.5           |                                                                                P=0.623                      | 
|POLY 6             |                                                                                P=0.114                      | 
|LOGISTIC REGRESSION|                                                                                P=0.230                      | 
|COCH-ARM / FISHERS |                                                                                P=0.252N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              18/50 (36%)                                       18/66 (27%)                  | 
|POLY-3 RATE (b)    |                              18/29.52                                          18/22.91                     | 
|POLY-3 PERCENT (g) |                              61.0%                                             78.6%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               222                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.131                      | 
|POLY 1.5           |                                                                                P=0.506                      | 
|POLY 6             |                                                                                P=0.024 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.301                      | 
|COCH-ARM / FISHERS |                                                                                P=0.211N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              15/50 (30%)                                       9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              15/27.64                                          9/17.30                      | 
|POLY-3 PERCENT (g) |                              54.3%                                             52.0%                        | 
|TERMINAL (d)       |                              6/10 (60%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.328                      | 
|POLY 3             |                                                                                P=0.623N                     | 
|POLY 1.5           |                                                                                P=0.198N                     | 
|POLY 6             |                                                                                P=0.408                      | 
|LOGISTIC REGRESSION|                                                                                P=0.110N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.030N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              7/50 (14%)                                        13/65 (20%)                  | 
|POLY-3 RATE (b)    |                              7/22.45                                           13/19.19                     | 
|POLY-3 PERCENT (g) |                              31.2%                                             67.7%                        | 
|TERMINAL (d)       |                              2/10 (20%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              525                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.012 *                    | 
|POLY 1.5           |                                                                                P=0.070                      | 
|POLY 6             |                                                                                P=0.002 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.008 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.278                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/50 (24%)                                       19/65 (29%)                  | 
|POLY-3 RATE (b)    |                              12/31.74                                          19/26.29                     | 
|POLY-3 PERCENT (g) |                              37.8%                                             72.3%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.127                      | 
|POLY 3             |                                                                                P=0.005 **                   | 
|POLY 1.5           |                                                                                P=0.046 *                    | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.418N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.341                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              1/22.01                                           2/11.15                      | 
|POLY-3 PERCENT (g) |                              4.5%                                              17.9%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              258                                               294                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.587                      | 
|POLY 3             |                                                                                P=0.453                      | 
|POLY 1.5           |                                                                                P=0.465                      | 
|POLY 6             |                                                                                P=0.668                      | 
|LOGISTIC REGRESSION|                                                                                P=0.719                      | 
|COCH-ARM / FISHERS |                                                                                P=0.598                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/50 (10%)                                        6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              5/22.51                                           6/14.33                      | 
|POLY-3 PERCENT (g) |                              22.2%                                             41.9%                        | 
|TERMINAL (d)       |                              2/10 (20%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              541                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.023 *                    | 
|POLY 3             |                                                                                P=0.231                      | 
|POLY 1.5           |                                                                                P=0.428                      | 
|POLY 6             |                                                                                P=0.115                      | 
|LOGISTIC REGRESSION|                                                                                P=0.336                      | 
|COCH-ARM / FISHERS |                                                                                P=0.567N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/50 (16%)                                        8/65 (12%)                   | 
|POLY-3 RATE (b)    |                              8/24.21                                           8/16.01                      | 
|POLY-3 PERCENT (g) |                              33.0%                                             50.0%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              258                                               222                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.044 *                    | 
|POLY 3             |                                                                                P=0.264                      | 
|POLY 1.5           |                                                                                P=0.526                      | 
|POLY 6             |                                                                                P=0.103                      | 
|LOGISTIC REGRESSION|                                                                                P=0.564                      | 
|COCH-ARM / FISHERS |                                                                                P=0.381N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              41/50 (82%)                                       43/65 (66%)                  | 
|POLY-3 RATE (b)    |                              41/41.99                                          43/44.52                     | 
|POLY-3 PERCENT (g) |                              97.7%                                             96.6%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.754N                     | 
|POLY 1.5           |                                                                                P=0.217N                     | 
|POLY 6             |                                                                                P=1.000                      | 
|LOGISTIC REGRESSION|                                                                                P=0.268N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.045N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/50 (20%)                                       4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              10/24.82                                          4/12.01                      | 
|POLY-3 PERCENT (g) |                              40.3%                                             33.3%                        | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              401                                               329                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.197                      | 
|POLY 3             |                                                                                P=0.596N                     | 
|POLY 1.5           |                                                                                P=0.156N                     | 
|POLY 6             |                                                                                P=0.692                      | 
|LOGISTIC REGRESSION|                                                                                P=0.438N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.025N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/50 (6%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              3/21.06                                           0/9.27                       | 
|POLY-3 PERCENT (g) |                              14.3%                                             0.0%                         | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.547N                     | 
|POLY 1.5           |                                                                                P=0.194N                     | 
|POLY 6             |                                                                                P=0.997N                     | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                P=0.079N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/50 (6%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              3/23.88                                           0/9.27                       | 
|POLY-3 PERCENT (g) |                              12.6%                                             0.0%                         | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              258                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.084N                     | 
|POLY 3             |                                                                                P=0.639N                     | 
|POLY 1.5           |                                                                                P=0.231N                     | 
|POLY 6             |                                                                                P=0.999N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.034N*                    | 
|COCH-ARM / FISHERS |                                                                                P=0.079N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              2/22.03                                           0/9.27                       | 
|POLY-3 PERCENT (g) |                              9.1%                                              0.0%                         | 
|TERMINAL (d)       |                              1/10 (10%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.459N                     | 
|POLY 3             |                                                                                P=0.735N                     | 
|POLY 1.5           |                                                                                P=0.357N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.234N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.187N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/50 (16%)                                        1/65 (2%)                    | 
|POLY-3 RATE (b)    |                              8/22.16                                           1/10.02                      | 
|POLY-3 PERCENT (g) |                              36.1%                                             10.0%                        | 
|TERMINAL (d)       |                              5/10 (50%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              601                                               456                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.516                      | 
|POLY 3             |                                                                                P=0.271N                     | 
|POLY 1.5           |                                                                                P=0.036N*                    | 
|POLY 6             |                                                                                P=0.936N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.626N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.005N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              45/50 (90%)                                       43/65 (66%)                  | 
|POLY-3 RATE (b)    |                              45/46.08                                          43/45.37                     | 
|POLY-3 PERCENT (g) |                              97.7%                                             94.8%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.002 **                   | 
|POLY 3             |                                                                                P=0.395N                     | 
|POLY 1.5           |                                                                                P=0.032N*                    | 
|POLY 6             |                                                                                P=0.809                      | 
|LOGISTIC REGRESSION|                                                                                P=0.022N*                    | 
|COCH-ARM / FISHERS |                                                                                P=0.002N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              41/50 (82%)                                       59/65 (91%)                  | 
|POLY-3 RATE (b)    |                              41/43.06                                          59/59.63                     | 
|POLY-3 PERCENT (g) |                              95.2%                                             99.0%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.153                      | 
|POLY 1.5           |                                                                                P=0.119                      | 
|POLY 6             |                                                                                P=0.393                      | 
|LOGISTIC REGRESSION|                                                                                P=0.065                      | 
|COCH-ARM / FISHERS |                                                                                P=0.135                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/50 (8%)                                         9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              4/23.68                                           9/17.28                      | 
|POLY-3 PERCENT (g) |                              16.9%                                             52.1%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.040 *                    | 
|POLY 3             |                                                                                P=0.021 *                    | 
|POLY 1.5           |                                                                                P=0.076                      | 
|POLY 6             |                                                                                P=0.005 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.367                      | 
|COCH-ARM / FISHERS |                                                                                P=0.249                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Red Pulp                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/50 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/21.06                                           2/11.23                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              17.8%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.289                      | 
|POLY 3             |                                                                                P=0.263                      | 
|POLY 1.5           |                                                                                P=0.227                      | 
|POLY 6             |                                                                                P=0.555                      | 
|LOGISTIC REGRESSION|                                                                                P=0.427                      | 
|COCH-ARM / FISHERS |                                                                                P=0.317                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              2/22.11                                           9/16.84                      | 
|POLY-3 PERCENT (g) |                              9.1%                                              53.4%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              474                                               217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.004 **                   | 
|POLY 3             |                                                                                P=0.003 **                   | 
|POLY 1.5           |                                                                                P=0.015 *                    | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.071                      | 
|COCH-ARM / FISHERS |                                                                                P=0.069                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 51      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         1/65 (2%)                    | 
|POLY-3 RATE (b)    |                              2/21.77                                           1/9.95                       | 
|POLY-3 PERCENT (g) |                              9.2%                                              10.1%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              593                                               482                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.399                      | 
|POLY 3             |                                                                                P=0.846                      | 
|POLY 1.5           |                                                                                P=0.622N                     | 
|POLY 6             |                                                                                P=0.973                      | 
|LOGISTIC REGRESSION|                                                                                P=0.751                      | 
|COCH-ARM / FISHERS |                                                                                P=0.402N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              1/21.78                                           2/11.13                      | 
|POLY-3 PERCENT (g) |                              4.6%                                              18.0%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              474                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.465                      | 
|POLY 3             |                                                                                P=0.452                      | 
|POLY 1.5           |                                                                                P=0.466                      | 
|POLY 6             |                                                                                P=0.665                      | 
|LOGISTIC REGRESSION|                                                                                P=0.669                      | 
|COCH-ARM / FISHERS |                                                                                P=0.598                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 52      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/50 (4%)                                         1/65 (2%)                    | 
|POLY-3 RATE (b)    |                              2/21.61                                           1/9.95                       | 
|POLY-3 PERCENT (g) |                              9.3%                                              10.1%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              593                                               482                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.399                      | 
|POLY 3             |                                                                                P=0.846                      | 
|POLY 1.5           |                                                                                P=0.621N                     | 
|POLY 6             |                                                                                P=0.971                      | 
|LOGISTIC REGRESSION|                                                                                P=0.715                      | 
|COCH-ARM / FISHERS |                                                                                P=0.402N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/50 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/21.06                                           2/10.92                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.3%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               237                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.163                      | 
|POLY 3             |                                                                                P=0.268                      | 
|POLY 1.5           |                                                                                P=0.226                      | 
|POLY 6             |                                                                                P=0.570                      | 
|LOGISTIC REGRESSION|                                                                                P=0.329                      | 
|COCH-ARM / FISHERS |                                                                                P=0.317                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 53      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/50 (0%)                                         3/65 (5%)                    | 
|POLY-3 RATE (b)    |                              0/21.06                                           3/12.13                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              24.7%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.180                      | 
|POLY 3             |                                                                                P=0.094                      | 
|POLY 1.5           |                                                                                P=0.103                      | 
|POLY 6             |                                                                                P=0.160                      | 
|LOGISTIC REGRESSION|                                                                                P=0.269                      | 
|COCH-ARM / FISHERS |                                                                                P=0.177                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/50 (2%)                                         5/65 (8%)                    | 
|POLY-3 RATE (b)    |                              1/21.72                                           5/13.58                      | 
|POLY-3 PERCENT (g) |                              4.6%                                              36.8%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              504                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.048 *                    | 
|POLY 3             |                                                                                P=0.039 *                    | 
|POLY 1.5           |                                                                                P=0.074                      | 
|POLY 6             |                                                                                P=0.027 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.191                      | 
|COCH-ARM / FISHERS |                                                                                P=0.176                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 54      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              45/46 (98%)                                       57/59 (97%)                  | 
|POLY-3 RATE (b)    |                              45/45.07                                          57/57.15                     | 
|POLY-3 PERCENT (g) |                              99.8%                                             99.7%                        | 
|TERMINAL (d)       |                              10/10 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              201                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=1.000N                     | 
|POLY 1.5           |                                                                                P=0.960N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.725                      | 
|COCH-ARM / FISHERS |                                                                                P=0.593N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/49 (4%)                                         0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              2/21.97                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              9.1%                                              0.0%                         | 
|TERMINAL (d)       |                              0/9 (0%)                                          0/0 (0%)                     | 
|FIRST INCIDENCE    |                              226                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.186N                     | 
|POLY 3             |                                                                                P=0.734N                     | 
|POLY 1.5           |                                                                                P=0.348N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.095N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.179N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 55      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/49 (12%)                                        3/66 (5%)                    | 
|POLY-3 RATE (b)    |                              6/21.98                                           3/11.81                      | 
|POLY-3 PERCENT (g) |                              27.3%                                             25.4%                        | 
|TERMINAL (d)       |                              2/9 (22%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              258                                               321                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.328                      | 
|POLY 3             |                                                                                P=0.701N                     | 
|POLY 1.5           |                                                                                P=0.334N                     | 
|POLY 6             |                                                                                P=0.687                      | 
|LOGISTIC REGRESSION|                                                                                P=0.489N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.122N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              29/49 (59%)                                       37/66 (56%)                  | 
|POLY-3 RATE (b)    |                              29/35.78                                          37/40.35                     | 
|POLY-3 PERCENT (g) |                              81.1%                                             91.7%                        | 
|TERMINAL (d)       |                              6/9 (67%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.100                      | 
|POLY 1.5           |                                                                                P=0.328                      | 
|POLY 6             |                                                                                P=0.033 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.393                      | 
|COCH-ARM / FISHERS |                                                                                P=0.443N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 56      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              23/23 (100%)                                      25/25 (100%)                 | 
|POLY-3 RATE (b)    |                              23/23.00                                          25/25.00                     | 
|POLY-3 PERCENT (g) |                              100.0%                                            100.0%                       | 
|TERMINAL (d)       |                              7/7 (100%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              209                                               245                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                (e)                          | 
|POLY 3             |                                                                                (e)                          | 
|POLY 1.5           |                                                                                (e)                          | 
|POLY 6             |                                                                                (e)                          | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                (e)                          | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/50 (8%)                                         2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              4/22.63                                           2/10.47                      | 
|POLY-3 PERCENT (g) |                              17.7%                                             19.1%                        | 
|TERMINAL (d)       |                              0/10 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              541                                               415                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.167                      | 
|POLY 3             |                                                                                P=0.767                      | 
|POLY 1.5           |                                                                                P=0.475N                     | 
|POLY 6             |                                                                                P=0.843                      | 
|LOGISTIC REGRESSION|                                                                                P=0.641                      | 
|COCH-ARM / FISHERS |                                                                                P=0.219N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/10/04                           EXPERIMENT: 96022 TEST: 02                                            Page 57      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/50 (16%)                                        0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              8/23.38                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              34.2%                                             0.0%                         | 
|TERMINAL (d)       |                              3/10 (30%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              494                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.506N                     | 
|POLY 3             |                                                                                P=0.194N                     | 
|POLY 1.5           |                                                                                P=0.012N*                    | 
|POLY 6             |                                                                                P=0.982N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.097N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              4000 NG/                                          4000 NG/                     | 
|                   |                              500UG ST                                          500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              17/50 (34%)                                       8/66 (12%)                   | 
|POLY-3 RATE (b)    |                              17/24.95                                          8/15.68                      | 
|POLY-3 PERCENT (g) |                              68.2%                                             51.0%                        | 
|TERMINAL (d)       |                              8/10 (80%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              273                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.022 *                    | 
|POLY 3             |                                                                                P=0.241N                     | 
|POLY 1.5           |                                                                                P=0.026N*                    | 
|POLY 6             |                                                                                P=0.798                      | 
|LOGISTIC REGRESSION|                                                                                P=0.490N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.005N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).