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TDMS Study 89010-02 Pathology Tables

NTP Experiment-Test: 89010-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04
Route: DOSED WATER                                                                                                Time: 10:36:24




       Facility:  Southern Research Institute

       Chemical CAS #:  PESTFERTMIX3

       Lock Date:  09/08/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89010-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:36:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          30           30           30           30           30                        
                                                                                                                                    
  Scheduled Sacrifice                                  9            8           10            9           10                        
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      1            1                        
    Accidently Killed                                               2                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           20           20           19           19                        
                                                                                                                                    
  Animals Examined Microscopically                    20           20           20           20           20                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (20)         (20)         (20)         (20)         (20)                      
      Inflammation, Focal                                                        2 (10%)                                            
   Pancreas                                           (20)         (20)         (20)         (20)         (20)                      
      Accessory Spleen                                                                                     1 (5%)                   
      Acinar Cell, Focal Cellular Change                            1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (20)         (20)         (20)         (20)         (20)                      
      Accessory Adrenal Cortical Nodule                                          1 (5%)       1 (5%)                                
   Parathyroid Gland                                  (19)         (18)         (19)         (19)         (19)                      
      Cyst                                                          1 (6%)                                 1 (5%)                   
   Thyroid Gland                                      (20)         (20)         (20)         (19)         (20)                      
      Degeneration, Cystic                                          2 (10%)      1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:36:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (20)         (20)         (20)         (20)         (20)                      
      Cyst                                                                                    1 (5%)                                
   Uterus                                             (20)         (20)         (20)         (20)         (20)                      
      Endometrium, Edema                                                                      1 (5%)       1 (5%)                   
      Endometrium, Hyperplasia, Cystic                10 (50%)      9 (45%)      8 (40%)     10 (50%)      9 (45%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (20)         (20)         (20)         (20)         (20)                      
      Cyst Epithelial Inclusion                                                                            1 (5%)                   
      Inflammation, Chronic, Focal                     1 (5%)       1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (20)         (20)         (20)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:36:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                   1 (5%)                                 1 (5%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:36:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          30           30           30           30           30                        
                                                                                                                                    
  Scheduled Sacrifice                                 10            9           10            9           10                        
  Early Deaths                                                                                                                      
    Accidently Killed                                               1                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           20           20           20           20                        
                                                                                                                                    
  Animals Examined Microscopically                    20           20           20           20           20                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (20)         (20)         (20)         (20)         (20)                      
      Mucosa, Cyst                                                                                         1 (5%)                   
   Liver                                              (20)         (20)         (20)         (20)         (20)                      
      Hemorrhage                                                                 1 (5%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            6 (30%)                                             6 (30%)                  
   Pancreas                                           (20)         (20)         (20)         (20)         (20)                      
      Atrophy, Focal                                                                          1 (5%)                                
   Salivary Glands                                    (20)         (20)         (20)         (20)         (20)                      
      Duct, Hyperplasia                                                                       1 (5%)                                
      Duct, Metaplasia, Squamous                                                              1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (20)         (20)         (20)         (20)         (20)                      
      Accessory Adrenal Cortical Nodule                                                                    1 (5%)                   
   Parathyroid Gland                                  (19)         (18)         (19)         (19)         (19)                      
      Cyst                                                                       2 (11%)      1 (5%)                                
   Thyroid Gland                                      (20)         (20)         (20)         (20)         (20)                      
      Degeneration, Cystic                             1 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:36:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Seminal Vesicle                                    (20)         (20)         (20)         (20)         (20)                      
      Developmental Malformation                                                                           1 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (19)         (20)         (20)         (20)         (18)                      
      Cyst                                                                                    1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (20)         (20)         (20)                      
      Pelvis, Dilatation                                                                                   1 (5%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 89010-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3                       Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 10:36:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.1X         1X           10X          100X                         
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Ureter                                                                                                 (1)                       
      Developmental Malformation                                                                           1 (100%)                 
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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