National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20251

TDMS Study 99022-02 Pathology Tables

NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03
Route: IN-UTERO                                                                                                   Time: 15:46:37

                                                           FINAL/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-87-1

       Lock Date:  06/20/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Merge     001   001,011
                               Merge     002   002,012
                               Merge     003   003,013
                               Merge     004   004,014
                               Merge     005   005,015
                               Merge     006   006,016
                               Merge     007   007,017
                               Merge     008   008,018
                               Merge     009   009,019
                               Merge     010   010,020

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           40           42                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           18           11           11           15                        
    Natural Death                                     14           13           15            9            8                        
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                   1                        
    Terminal Sacrifice                                19           17           24           19           18                        
    Natural Death                                                   1                         1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           40           42                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (49)         (48)         (49)         (40)         (40)                      
   Intestine Large, Cecum                             (47)         (48)         (45)         (38)         (40)                      
      Leiomyosarcoma                                                                                       1 (3%)                   
   Intestine Small, Duodenum                          (50)         (50)         (48)         (40)         (42)                      
   Intestine Small, Jejunum                           (46)         (49)         (46)         (40)         (40)                      
      Histiocytic Sarcoma                                           1 (2%)                                 1 (3%)                   
   Intestine Small, Ileum                             (47)         (48)         (45)         (38)         (40)                      
   Liver                                              (50)         (50)         (50)         (40)         (42)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Hepatocellular Carcinoma                         2 (4%)       1 (2%)                                 2 (5%)                   
      Hepatocellular Adenoma                           2 (4%)       3 (6%)       4 (8%)       2 (5%)       2 (5%)                   
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)       1 (2%)                    2 (5%)                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (3%)       2 (5%)                   
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Plasma Cell Tumor Malignant                                   1 (2%)       1 (2%)                                             
   Mesentery                                          (4)          (8)          (7)          (3)          (5)                       
      Fibrosarcoma, Metastatic, Skin                                1 (13%)                                                         
      Hemangioma                                                                 1 (14%)                                            
      Histiocytic Sarcoma                                                                                  1 (20%)                  
      Plasma Cell Tumor Malignant                                   1 (13%)                                                         
   Pancreas                                           (50)         (49)         (49)         (40)         (41)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Salivary Glands                                    (50)         (49)         (49)         (40)         (42)                      
   Stomach, Forestomach                               (50)         (50)         (49)         (40)         (42)                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (49)         (40)         (42)                      
      Carcinoid Tumor Malignant                                                                            1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (2)                                                 
   Heart                                              (50)         (49)         (50)         (40)         (42)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Plasma Cell Tumor Malignant                                   1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (38)         (42)                      
      Carcinoma                                                                               1 (3%)                                
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
      Subcapsular, Adenoma                             1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (50)         (49)         (50)         (38)         (42)                      
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (49)         (49)         (40)         (41)                      
      Adenoma                                                                                 1 (3%)       2 (5%)                   
   Parathyroid Gland                                  (45)         (45)         (48)         (37)         (36)                      
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (50)         (40)         (42)                      
      Pars Distalis, Adenoma                                        1 (2%)       1 (2%)       1 (3%)       1 (2%)                   
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (50)         (40)         (42)                      
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (40)         (42)                      
   Ovary                                              (50)         (50)         (49)         (40)         (42)                      
      Cystadenoma                                      2 (4%)       1 (2%)       2 (4%)                    1 (2%)                   
      Granulosa Cell Tumor Malignant                                                          2 (5%)       1 (2%)                   
      Hemangioma                                                                              1 (3%)                                
      Hemangiosarcoma                                                                                      1 (2%)                   
      Luteoma                                                       1 (2%)                                                          
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
      Sertoli Cell Tumor Benign                                                  1 (2%)                                             
   Uterus                                             (50)         (50)         (49)         (40)         (42)                      
      Hemangioma                                                    1 (2%)                    1 (3%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                 2 (5%)                                
      Leiomyoma                                                     1 (2%)       1 (2%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    1 (2%)       1 (2%)       1 (2%)       1 (3%)       1 (2%)                   
   Vagina                                             (49)         (49)         (47)         (40)         (41)                      
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (40)         (42)                      
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                    1 (2%)                   
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
   Lymph Node                                         (14)         (23)         (16)         (12)         (16)                      
      Histiocytic Sarcoma                                           1 (4%)                                                          
      Plasma Cell Tumor Malignant                                                1 (6%)                                             
      Deep Cervical, Plasma Cell Tumor Malignant                                 1 (6%)                                             
      Iliac, Histiocytic Sarcoma                                    1 (4%)                                                          
      Iliac, Plasma Cell Tumor Malignant                                         1 (6%)                                             
      Inguinal, Plasma Cell Tumor Malignant                                      1 (6%)                                             
      Mediastinal, Histiocytic Sarcoma                                           1 (6%)                    1 (6%)                   
      Mediastinal, Plasma Cell Tumor Malignant                      2 (9%)       1 (6%)                                             
      Pancreatic, Hemangioma                                                     1 (6%)                                             
      Pancreatic, Plasma Cell Tumor Malignant                                    1 (6%)                                             
      Popliteal, Plasma Cell Tumor Malignant                                     1 (6%)                                             
      Renal, Histiocytic Sarcoma                                    1 (4%)                                                          
      Renal, Plasma Cell Tumor Malignant                            1 (4%)       1 (6%)                                             
   Lymph Node, Mandibular                             (49)         (47)         (49)         (40)         (42)                      
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Plasma Cell Tumor Malignant                                   1 (2%)       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mesenteric                             (50)         (48)         (46)         (40)         (42)                      
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                    2 (5%)                   
      Plasma Cell Tumor Malignant                                   1 (2%)       1 (2%)                                             
   Spleen                                             (50)         (50)         (49)         (40)         (42)                      
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                    1 (2%)                   
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Plasma Cell Tumor Malignant                                   1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Thymus                                             (49)         (44)         (46)         (36)         (42)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)       1 (3%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                    2 (5%)                   
      Plasma Cell Tumor Malignant                                   2 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (40)         (42)                      
      Carcinoma                                        2 (4%)       2 (4%)       2 (4%)       1 (3%)       1 (2%)                   
   Skin                                               (50)         (50)         (49)         (40)         (42)                      
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                    1 (3%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)       1 (2%)       1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (40)         (42)                      
      Osteoma                                                       1 (2%)                    1 (3%)                                
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (5)          (2)          (1)          (1)          (4)                       
      Sarcoma                                          1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (40)         (42)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Spinal Cord                                        (50)         (50)         (50)         (40)         (42)                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - cont                                                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (40)         (42)                      
      Alveolar/Bronchiolar Adenoma                     7 (14%)      3 (6%)       7 (14%)      4 (10%)      7 (17%)                  
      Alveolar/Bronchiolar Adenoma, Multiple                        3 (6%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       6 (12%)      6 (12%)      4 (10%)      3 (7%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                    2 (4%)       4 (10%)      2 (5%)                   
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Lung                                                                               1 (3%)                                
      Hemangiosarcoma                                                                                      1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (3%)                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Plasma Cell Tumor Malignant                                   1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (40)         (42)                      
      Histiocytic Sarcoma                                                                     1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (49)         (49)         (50)         (40)         (41)                      
      Adenoma                                          4 (8%)       6 (12%)      9 (18%)      4 (10%)      7 (17%)                  
      Carcinoma                                                                  1 (2%)                    1 (2%)                   
      Histiocytic Sarcoma                                                                     1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (40)         (42)                      
      Histiocytic Sarcoma                                                                     1 (3%)                                
      Plasma Cell Tumor Malignant                                   1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (49)         (40)         (42)                      
      Histiocytic Sarcoma                                                                     1 (3%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(40)        *(42)                      
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       2 (5%)       2 (5%)                   
      Leukemia Granulocytic                                                      1 (2%)                    1 (2%)                   
      Lymphoma Malignant                              19 (38%)     19 (38%)     20 (40%)     16 (40%)     17 (40%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          33          38          31          33                           
     Total Primary Neoplasms                           55          76          85          48          57                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          17          23          14          16                           
     Total Benign Neoplasms                            19          27          32          16          23                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          28          31          25          27                           
     Total Malignant Neoplasms                         36          49          53          32          34                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           3           2           1                           
     Total Metastatic Neoplasm                          2           4           6           2           1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           37           32                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           20           25           23           12                        
    Natural Death                                      7            9           11            5           10                        
    Accidently Killed                                                            1            1            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           20           13            7            7                        
    Moribund Sacrifice                                              1                                                               
    Natural Death                                                                                          1                        
  Other                                                                                       1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           37           32                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (46)         (46)         (33)         (27)                      
   Intestine Large, Colon                             (48)         (50)         (49)         (37)         (32)                      
   Intestine Large, Cecum                             (49)         (49)         (48)         (35)         (30)                      
   Intestine Small, Duodenum                          (49)         (50)         (49)         (36)         (32)                      
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (50)         (46)         (36)         (29)                      
   Intestine Small, Ileum                             (49)         (48)         (47)         (35)         (30)                      
   Liver                                              (50)         (50)         (50)         (37)         (32)                      
      Hemangiosarcoma                                  7 (14%)      4 (8%)       3 (6%)       1 (3%)       3 (9%)                   
      Hepatoblastoma                                   1 (2%)                    2 (4%)                                             
      Hepatocellular Carcinoma                         4 (8%)       5 (10%)      5 (10%)      2 (5%)       1 (3%)                   
      Hepatocellular Carcinoma, Multiple               2 (4%)       1 (2%)       1 (2%)       2 (5%)       1 (3%)                   
      Hepatocellular Adenoma                          12 (24%)      5 (10%)      5 (10%)      5 (14%)      4 (13%)                  
      Hepatocellular Adenoma, Multiple                 2 (4%)       6 (12%)      5 (10%)      3 (8%)                                
      Hepatocholangiocarcinoma                                                                             1 (3%)                   
   Pancreas                                           (50)         (50)         (50)         (37)         (31)                      
   Salivary Glands                                    (50)         (50)         (50)         (37)         (32)                      
      Carcinoma                                                     1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (50)         (37)         (32)                      
      Squamous Cell Papilloma                                                                 1 (3%)                                
   Stomach, Glandular                                 (49)         (50)         (50)         (37)         (32)                      
      Adenoma                                                                                              1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (37)         (32)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (3%)                                
      Sarcoma                                                                                 1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (37)         (32)                      
      Adenoma                                          2 (4%)                    1 (2%)       1 (3%)                                
      Subcapsular, Adenoma                                                                    2 (5%)                                
   Adrenal Medulla                                    (50)         (50)         (49)         (37)         (32)                      
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (36)         (31)                      
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (48)         (49)         (49)         (36)         (31)                      
      Schwannoma Malignant, Metastatic, Brain          1 (2%)                    1 (2%)                                             
      Pars Distalis, Adenoma                                        1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (37)         (32)                      
      Follicular Cell, Adenoma                                                                1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (37)         (32)                      
   Prostate                                           (50)         (50)         (50)         (37)         (32)                      
   Seminal Vesicle                                    (50)         (50)         (50)         (37)         (32)                      
   Testes                                             (50)         (50)         (50)         (37)         (32)                      
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Bilateral, Interstitial Cell, Carcinoma                                                 1 (3%)                                
      Interstitial Cell, Adenoma                                                              1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (37)         (32)                      
      Hemangiosarcoma                                               1 (2%)                                                          
   Lymph Node                                         (12)         (10)         (15)         (6)          (2)                       
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (17%)                               
      Mediastinal, Hemangiosarcoma                                               1 (7%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (49)         (37)         (32)                      
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (36)         (32)                      
   Spleen                                             (49)         (50)         (50)         (37)         (32)                      
      Hemangiosarcoma                                  3 (6%)       2 (4%)       1 (2%)                    1 (3%)                   
   Thymus                                             (48)         (45)         (47)         (33)         (32)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (37)         (32)                      
      Squamous Cell Papilloma                                                                 1 (3%)                                
      Subcutaneous Tissue, Basal Cell Carcinoma                     1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (3%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (37)         (32)                      
      Schwannoma Malignant, Metastatic, Brain                                    1 (2%)                                             
   Skeletal Muscle                                    (1)          (2)          (1)          (3)          (2)                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (50%)                   1 (33%)      1 (50%)                  
      Hemangioma                                                    1 (50%)                                                         
      Hemangiosarcoma                                                                         1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (37)         (32)                      
      Oligodendroglioma Malignant                                                                          1 (3%)                   
      Schwannoma Malignant                                                       1 (2%)                                             
      Cranial Nerve, Schwannoma Malignant              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (37)         (32)                      
      Alveolar/Bronchiolar Adenoma                     7 (14%)     13 (26%)      8 (16%)      8 (22%)     10 (31%)                  
      Alveolar/Bronchiolar Adenoma, Multiple           3 (6%)                                 1 (3%)       1 (3%)                   
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       6 (12%)      5 (10%)      5 (14%)      5 (16%)                  
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       5 (10%)      1 (2%)       6 (16%)      3 (9%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (36)         (32)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (50)         (49)         (37)         (32)                      
      Adenoma                                         11 (22%)      8 (16%)      9 (18%)      3 (8%)       4 (13%)                  
      Carcinoma                                                                  1 (2%)                    1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (37)         (32)                      
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (37)         (32)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(37)        *(32)                      
      Lymphoma Malignant                               6 (12%)      9 (18%)      7 (14%)      4 (11%)      3 (9%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 10/08/03  
Route: IN-UTERO                                                                                                   Time: 15:46:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          35          34          25          26                           
     Total Primary Neoplasms                           68          71          61          51          40                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27          23          27          18          16                           
     Total Benign Neoplasms                            39          35          30          27          20                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          27          20          20          17                           
     Total Malignant Neoplasms                         29          36          31          24          20                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           1           1           1                           
     Total Metastatic Neoplasm                          2           1           2           3           1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.