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TDMS Study 99022-02 Pathology Tables

NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04
Route: IN-UTERO                                                                                                   Time: 14:01:42

                                                   FINAL #2; REVISION #1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-87-1

       Lock Date:  06/20/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Merge     006   006,016
                               Merge     007   007,017
                               Merge     008   008,018
                               Merge     009   009,019
                               Merge     010   010,020
                               Merge     001   001,011
                               Merge     002   002,012
                               Merge     003   003,013
                               Merge     004   004,014
                               Merge     005   005,015



























                                                              Page   1


NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|             
                                           | 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    0                                      | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/KG/DY                               | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |                                                             2            |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Erosion                              |                                                                          |             
      Epithelium, Hyperplasia              |       2        3              2  3           2                    2      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +|             
      Amyloid Deposition                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |       X                                                                  |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 3        4                                   2     2           4         |             
      Infiltration Cellular, Mixed Cell    |                   2                       2                          3   |             
      Necrosis, Focal                      |    3                 3                    1        2  3                  |             
      Thrombosis                           |                                                                          |             
      Hepatocyte, Hypertrophy              |                                                                   2      |             
      Kupffer Cell, Hyperplasia            |    3                                                                     |             
      Kupffer Cell, Pigmentation           |    2        2                                                        3   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                 +                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|             
                                           | 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    0                                      | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/KG/DY                               | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hemorrhage                           |                                        4                                 |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Epithelium, Hyperplasia              |    1                                         2                           |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Erosion                              |                                                       2                  |             
      Glands, Hyperplasia, Cystic          | 3                    3  2     2        2                             2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Cardiomyopathy                       |    2                    1                             2                  |             
      Inflammation, Chronic                |                2                       2              2                  |             
      Mineralization                       |    3                                            3                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      3                 3     3                          3|             
      Amyloid Deposition                   |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|             
                                           | 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    0                                      | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/KG/DY                               | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                            1            |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                                                     |             
      Pars Distalis, Hyperplasia, Focal    |                1                                                         |             
      Pars Intermedia, Hyperplasia         |                         3                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Degeneration, Cystic                 | 3  2           3  2  1     1     3  3  2           3        2        3   |             
      Follicular Cell, Hyperplasia         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X           X           X                       X        X            |             
      Inflammation, Chronic                |       2        3  3        3     2        4        3        2     4  2  4|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 | X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X  X  X|             
      Hematocyst                           |                                                             X            |             
      Hemorrhage                           |                      3                                                   |             
      Corpus Luteum, Hyperplasia           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                4         |             
      Inflammation, Chronic                |    3                                                                     |             
      Thrombosis                           |                X                                                         |             
      Endometrium, Hyperplasia, Cystic     |    1  1        3  3  3  2  3        2  2     2     2        3  2  2  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|             
                                           | 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    0                                      | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/KG/DY                               | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     3  4     4     3  4  3  2     2  2  3  3  4  4  4  2     4  2  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +  +        +  +                       +  +        +            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    4                     |             
      Hyperplasia, Plasma Cell             |                         3                                                |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |          4                                                               |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |          3                                                               |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |          3                                                               |             
      Mediastinal, Hemorrhage              |             4                                                            |             
      Mediastinal, Hyperplasia, Lymphoid   |          3                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Atrophy                              |                               3                                          |             
      Ectasia                              | 4                                                                 4      |             
      Hematopoietic Cell Proliferation     |                3                             2     2              2      |             
      Hemorrhage                           |    3                       4                                             |             
      Hyperplasia, Lymphoid                |       3  3     4  2                          4        4           3      |             
      Hyperplasia, Plasma Cell             | 3                       3                    3     4                     |             
      Infiltration Cellular, Plasma Cell   | 3                                            3                           |             
      Pigmentation                         |    2                             2  2  2                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               4                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|             
                                           | 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    0                                      | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/KG/DY                               | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                3           2                                             |             
      Hemorrhage                           |    3              3        2                                         3   |             
      Hyperplasia, Lymphoid                | 1                                         2                       1      |             
      Pigmentation                         |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4        4     3        4  1     2  1        3     4  3  2  3  4  4     2|             
      Pigmentation                         |    3        2                 3     2                                3  2|             
      Lymphoid Follicle, Atrophy           |    3        3                 4                                          |             
      Lymphoid Follicle, Hyperplasia       |                   3     2                                3        3      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |    3        3     2           2                                      3   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    2           3  3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3     3  1  1                    2     3  2            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             4                 3                                          |             
      Inflammation, Chronic                |                                  2                                       |             
      Ulcer                                | 4     3        4        4                    4     4  4                  |             
      Epidermis, Hyperplasia               | 4     3        2        3        4                 4                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               2                                      3   |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |          +                       +              +                        |             
      Inflammation, Chronic                |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|             
                                           | 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    0                                      | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/KG/DY                               | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |          +        +                                +        +            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                 2                        |             
      Foreign Body                         |                   X  X                                            X      |             
      Hemorrhage                           |       3                    1                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 3  2              2                 2              2     2        2      |             
      Infiltration Cellular, Mixed Cell    |                                                          2        3      |             
      Inflammation, Chronic                |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X     X                                                                  |             
      Inflammation, Chronic                | 1  2  2        1                    1        2                    2  3   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |       1                                                                  |             
      Infiltration Cellular, Mixed Cell    | 2                             3     2                          2  2      |             
      Inflammation, Chronic                |    4                                                     3               |             
      Metaplasia, Osseous                  |                         1                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|             
                                           | 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    0                                      | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
    MG/KG/DY                               | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Nephropathy                          | 2           4        1  2  1  4  1  2  2  1  1        1  3        2  3   |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Dilatation             |    3                                                                     |             
      Renal Tubule, Pigmentation           |                                                             3            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                   2                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6|            |
                             DAY ON TEST   | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7|            |
                                           | 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7|      A     |
    0                                      | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2|      L     |
    MG/KG/DY                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Edema                                |                         2                    2                           |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                   3      |      1  3.0|
      Erosion                              |                                                 2                        |      1  2.0|
      Epithelium, Hyperplasia              |          2  2  1              2                 2  2                     |     12  2.1|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Amyloid Deposition                   |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Amyloid Deposition                   |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                   3      |      1  3.0|
      Angiectasis                          |    3                                                                     |      1  3.0|
      Cyst                                 |                                           X                              |      2     |
      Eosinophilic Focus                   |                                                 X                        |      1     |
      Hematopoietic Cell Proliferation     |    4                                      2              3               |      8  3.0|
      Infiltration Cellular, Mixed Cell    |                      1  2                       2                 2      |      7  2.0|
      Necrosis, Focal                      |                                                 1                        |      6  2.2|
      Thrombosis                           |    X                                                                     |      1     |
      Hepatocyte, Hypertrophy              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6|            |
                             DAY ON TEST   | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7|            |
                                           | 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7|      A     |
    0                                      | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2|      L     |
    MG/KG/DY                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           |                         1                                                |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                                                  +                  |   4        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Thrombosis                           |    X                                                                     |      1     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis, Focal                      |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                  2              3                        |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                    2                     |      1  2.0|
      Epithelium, Hyperplasia              |                         1                          2                     |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Glands, Hyperplasia, Cystic          |                                                                          |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                 +   |   3        |
      Inflammation, Chronic                |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Cardiomyopathy                       |                                                                          |      3  1.7|
      Inflammation, Chronic                |       1  2     2        3                                                |      7  2.0|
      Mineralization                       |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6|            |
                             DAY ON TEST   | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7|            |
                                           | 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7|      A     |
    0                                      | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2|      L     |
    MG/KG/DY                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    3  3  3           3     3                                         3   |     10  3.0|
      Amyloid Deposition                   |                                                                   3      |      1  3.0|
      Capsule, Hyperplasia                 |                                                                   2      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                                      X  X|      3     |
      Pars Distalis, Hyperplasia, Focal    |    3                                      1                              |      3  1.7|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                   3      |      1  3.0|
      Degeneration, Cystic                 |    3     1     2     2  1  1  2  1  2     3  2              3  1  2      |     26  2.1|
      Follicular Cell, Hyperplasia         |                1  2                             1                        |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X     X  X  X  X  X  X  X  X  X        X  X  X     X        X        X|     22     |
      Inflammation, Chronic                |       2  4  2           2  2  3  2  2           2     1        2        2|     23  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6|            |
                             DAY ON TEST   | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7|            |
                                           | 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7|      A     |
    0                                      | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2|      L     |
    MG/KG/DY                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Amyloid Deposition                   |                                                                   4      |      1  4.0|
      Angiectasis                          |             2                                                            |      1  2.0|
      Cyst                                 |       X  X  X  X        X  X  X  X  X     X  X     X     X  X     X     X|     38     |
      Hematocyst                           |                                                                          |      1     |
      Hemorrhage                           |                                                             2            |      2  2.5|
      Corpus Luteum, Hyperplasia           |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Thrombosis                           |          X                                                               |      2     |
      Endometrium, Hyperplasia, Cystic     |    3                 2  3                                   2     2     2|     22  2.2|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                            X                                             |      2     |
      Epithelium, Hyperplasia              |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  4  2  3  2                 2        3  3        2  3  4     2     3   |     33  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +     +                 +                             +     +     +   |  14        |
      Hematopoietic Cell Proliferation     |                                                          3               |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Hyperplasia, Plasma Cell             |                                                          4               |      2  3.5|
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  4.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                4     2   |      2  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |          3                                                               |      1  3.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6|            |
                             DAY ON TEST   | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7|            |
                                           | 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7|      A     |
    0                                      | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2|      L     |
    MG/KG/DY                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mediastinal, Hemorrhage              |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                       3                  |      1  3.0|
      Atrophy                              |                                                       2                  |      2  2.5|
      Ectasia                              |                                                                          |      2  4.0|
      Hematopoietic Cell Proliferation     |                         2     2                          2               |      7  2.1|
      Hemorrhage                           |                                                                   3      |      3  3.3|
      Hyperplasia, Lymphoid                |                                                             2     3      |      9  3.1|
      Hyperplasia, Plasma Cell             |                                                          3               |      5  3.2|
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.0|
      Pigmentation                         |                                                             2            |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                       2                  |      2  3.0|
      Ectasia                              |    2                                      2                              |      2  2.0|
      Hematopoietic Cell Proliferation     |    3        2                                            4        2      |      6  2.7|
      Hemorrhage                           |             2                 2  2  3        2  3  3     2               |     12  2.5|
      Hyperplasia, Lymphoid                |       2              2                       2                           |      6  1.7|
      Pigmentation                         |             2                                                            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  4     3  2  1     2        2  4        4  1  2  3  4  4     2  2      |     31  2.8|
      Pigmentation                         |       2                 3                    2  2  3        2        3   |     13  2.5|
      Lymphoid Follicle, Atrophy           |                                                    3                     |      4  3.3|
      Lymphoid Follicle, Hyperplasia       |          2           2                       2                           |      7  2.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                        2                             3   |      7  2.6|
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Hyperplasia, Lymphoid                |    3  3              3        2                                          |      7  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6|            |
                             DAY ON TEST   | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7|            |
                                           | 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7|      A     |
    0                                      | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2|      L     |
    MG/KG/DY                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2                                                                     |      9  2.1|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                    2                     |      3  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                          4               |      8  3.9|
      Epidermis, Hyperplasia               |                                                          4               |      7  3.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                     +                  |   5        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +  +                             +               |   7        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      3     |
      Hemorrhage                           | 2  1     1                                         2  1                  |      7  1.6|
      Hyperplasia, Lymphoid                |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6|            |
                             DAY ON TEST   | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7|            |
                                           | 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7|      A     |
    0                                      | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2|      L     |
    MG/KG/DY                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Infiltration Cellular, Histiocyte    |    3                    2     1  4                    3                  |     12  2.3|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      2     |
      Inflammation, Chronic                |                                  1           1                          2|     11  1.6|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                               3                                   4      |      2  3.5|
      Cyst                                 |                                                    X        X            |      2     |
      Hydronephrosis                       |       2                                                                  |      2  1.5|
      Infiltration Cellular, Mixed Cell    |    1  2                             2           2  3                     |     10  2.1|
      Inflammation, Chronic                |                                                                      2   |      3  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          | 2  1  2  2  1  2     1     2  3                 1  4  2           1  4   |     29  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                            4                                             |      1  4.0|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |          2                                                               |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|             
                             DAY ON TEST   | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|             
                                           | 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50                                     | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                 2                                         3   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                      2   |             
      Epithelium, Hyperplasia              |       2                                      3           3  2            |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                         2|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                X         |             
      Hematopoietic Cell Proliferation     |                                              3        4                  |             
      Infiltration Cellular, Mixed Cell    |       2                                                  3     3         |             
      Necrosis, Focal                      |       4  3                          2  4                 1     4         |             
      Regeneration                         |                                                                          |             
      Hepatocyte, Hypertrophy              |                                                             2     2      |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                                              2                 3     2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +                                   +  +  +     +           +        +|             
      Hemorrhage                           |                                                                         3|             
      Fat, Necrosis                        |    4                                         4     2           4         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|             
                             DAY ON TEST   | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|             
                                           | 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50                                     | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Edema                                |                                                                          |             
      Acinus, Cytoplasmic Alteration       |                                                             3           3|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2  2     2                             2                          2|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                                                        2      |             
      Epithelium, Hyperplasia              |                                              1                 1         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Edema                                |          2                                                               |             
      Erosion                              | 2                                                                        |             
      Glands, Hyperplasia, Cystic          |                               3                          2        2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          3                                3     3           3        3   |             
      Hyperplasia, Diffuse                 |          2                                                        2      |             
      Capsule, Hyperplasia                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                          1                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                          2     2                 3   |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|             
                             DAY ON TEST   | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|             
                                           | 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50                                     | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                2  2           1                                         3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Degeneration, Cystic                 |             3              3  2  4           2        2  3     2         |             
      Follicular Cell, Hyperplasia         |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X     X              X  X     X           X     X                     |             
      Inflammation, Chronic                | 3  3     2  3  2  2  2     3  4  3           3           2        2     4|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Cyst                                 |       X  X  X     X  X     X  X  X  X        X     X  X  X  X     X  X  X|             
      Hemorrhage                           |          3                                                               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              2                           |             
      Inflammation, Chronic                |                   2                                                      |             
      Endometrium, Hyperplasia, Cystic     | 4  3     1     2  3  2  1  3  2  2           2     3  2  3     3     3  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3     3  2  2           3              4     4  3  4     4  2     3|             
      Myelofibrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +                       +  +  +     +     +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 4                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|             
                             DAY ON TEST   | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|             
                                           | 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50                                     | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Bronchial, Hemorrhage                |                                                                          |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                      4   |             
      Inguinal, Pigmentation               |                                                          1               |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Renal, Ectasia                       |                                                                   3      |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                       2                  |             
      Renal, Hemorrhage                    |                                                       2           3      |             
      Renal, Hyperplasia, Lymphoid         |                                                             3            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           | 2        2           1                                2                  |             
      Hyperplasia, Lymphoid                | 2                                            3  2                       3|             
      Pigmentation                         |                      3                                         2        2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                        3      |             
      Ectasia                              |                   2     3                                                |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Hemorrhage                           |                         2  2                 2                    3      |             
      Hyperplasia, Lymphoid                |                         2                                   2           3|             
      Pigmentation                         |                         2        2           2              2            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2           1              2  2     3  3  4     2  4  2     3        3|             
      Pigmentation                         | 2  2  3  3     2     2  2        2        2              2  2  3  4  3   |             
      Lymphoid Follicle, Atrophy           |          3                                                        3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|             
                             DAY ON TEST   | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|             
                                           | 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50                                     | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                  2                          2            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                       4  2        4      |             
      Hyperplasia, Lymphoid                | 3                                                                    4  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                  2           2  3|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3  3                                                            |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                   3      |             
      Cranium, Hyperostosis                |                                                          3               |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      4   |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |       +                    +                          +                  |             
      Atrophy                              |                            2                                             |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                        2                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|             
                             DAY ON TEST   | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|             
                                           | 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50                                     | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |    3                                                  3  2               |             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Infiltration Cellular, Histiocyte    |       2  2                 3  3  4                                1      |             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               1                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X           X                       X     X                    X   |             
      Hydronephrosis                       | 3  2        3  3                                                  3      |             
      Infarct                              |                               2                                          |             
      Infiltration Cellular, Mixed Cell    | 2        3     3     2                                   3  2  2  3     2|             
      Nephropathy                          |       3  4  1  4     2           1           1  3     2  4  4  1  4  3  2|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |             3                                                           4|             
      Renal Tubule, Dilatation             |          3                                                               |             
      Renal Tubule, Pigmentation           |             3                                                            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6|            |
                             DAY ON TEST   | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6|            |
                                           | 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    50                                     | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3|      L     |
    MG/KG/DY                               | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |          2        2              2                                       |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Eosinophilic Focus                   |                                  X                                       |      2     |
      Hematopoietic Cell Proliferation     |       2                    4                    4                        |      5  3.4|
      Infiltration Cellular, Mixed Cell    | 3                    2                                         2         |      6  2.5|
      Necrosis, Focal                      |          1           1                                                   |      8  2.5|
      Regeneration                         |                                     3                                    |      1  3.0|
      Hepatocyte, Hypertrophy              |          2  3                          2                          2      |      6  2.2|
      Hepatocyte, Vacuolization Cytoplasmic|                                     4                                    |      1  4.0|
      Kupffer Cell, Pigmentation           |                                                                   2      |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                      +   |   8        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6|            |
                             DAY ON TEST   | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6|            |
                                           | 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    50                                     | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3|      L     |
    MG/KG/DY                               | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        |                                                                      3   |      5  3.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 2                                                                        |      1  2.0|
      Edema                                |          2  2                                                            |      2  2.0|
      Acinus, Cytoplasmic Alteration       |             3           3                                                |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                2         |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |          2                                            3           2      |      5  2.2|
      Epithelium, Hyperplasia              |                                     1                                    |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          X                                                               |      2     |
      Edema                                |             2                                                            |      2  2.0|
      Erosion                              | 2                                                                        |      2  2.0|
      Glands, Hyperplasia, Cystic          |    2     2  3  2           2     2                          2        3  2|     12  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 2     1                                                                  |      2  1.5|
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
      Mineralization                       |    3                                                           1         |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    | 3        3                                               3               |      8  3.0|
      Hyperplasia, Diffuse                 |                                                                          |      2  2.0|
      Capsule, Hyperplasia                 |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6|            |
                             DAY ON TEST   | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6|            |
                                           | 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    50                                     | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3|      L     |
    MG/KG/DY                               | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                             1            |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                             2            |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 | 4  3     3     1        2     2        2        3  2  3                  |     18  2.6|
      Follicular Cell, Hyperplasia         |                1                                                         |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X     X        X  X     X        X  X     X        X        X            |     18     |
      Inflammation, Chronic                |                2  3              2                 2        2            |     19  2.6|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 | X  X  X  X  X        X  X  X  X  X  X  X           X     X     X  X  X  X|     35     |
      Hemorrhage                           |                                                       2                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |    2  3  2     3     1           3        3                       2  3  3|     27  2.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6|            |
                             DAY ON TEST   | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6|            |
                                           | 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    50                                     | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3|      L     |
    MG/KG/DY                               | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4  3  4     3              4     2  2           4  4           2  2     3|     24  3.1|
      Myelofibrosis                        |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +                 +     +        +     +  +  +  +              +|  23        |
      Hematopoietic Cell Proliferation     |                            4                                             |      1  4.0|
      Hyperplasia, Lymphoid                |       4                    4                                             |      3  4.0|
      Bronchial, Hemorrhage                |                                                       3                  |      1  3.0|
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                 3                        |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         | 4                                               4                        |      2  4.0|
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                            3                                             |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |       4                    2                    4                        |      4  3.5|
      Inguinal, Pigmentation               |                                                                          |      1  1.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                 4                        |      1  4.0|
      Mediastinal, Hemorrhage              |          2                                                               |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |    2     2                                                               |      2  2.0|
      Mediastinal, Pigmentation            |    2                                                                     |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  3.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      2  2.5|
      Renal, Hyperplasia, Lymphoid         | 4                                               4                        |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |          3                                                               |      2  3.0|
      Ectasia                              |                            4                                             |      1  4.0|
      Hematopoietic Cell Proliferation     |       3                    3                    3                        |      3  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6|            |
                             DAY ON TEST   | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6|            |
                                           | 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    50                                     | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3|      L     |
    MG/KG/DY                               | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hemorrhage                           |                                                                          |      4  1.8|
      Hyperplasia, Lymphoid                | 4     4              2     4  2                 2                        |     10  2.8|
      Pigmentation                         | 2                                                                        |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |          3                                                     3         |      4  2.8|
      Ectasia                              |                                                                      2   |      3  2.3|
      Hematopoietic Cell Proliferation     | 2     3                                         2           2        2   |      6  2.2|
      Hemorrhage                           | 2                 2                 2                       3        1  2|     10  2.1|
      Hyperplasia, Lymphoid                | 3                    2  2                                   3            |      7  2.4|
      Pigmentation                         |                   2                                         2           2|      7  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3     4                    4  2                 4  3           3     2  3|     21  2.8|
      Pigmentation                         |    3     2     2  3  2  3              3     2                    2     2|     24  2.4|
      Lymphoid Follicle, Atrophy           |          2              2                                      2  3      |      6  2.5|
      Lymphoid Follicle, Hyperplasia       |             2                                                            |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  44        |
      Atrophy                              | 2                       2                                         2      |      3  2.0|
      Hemorrhage                           |                                                                2         |      4  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  3  3                                            1           3         |      9  2.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |          3  3                          3     3                    3      |      7  3.0|
      Ulcer                                | 4     4                    4                    4  4                     |      5  4.0|
      Epidermis, Hyperplasia               | 4     4                    4                    3  4                     |      5  3.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6|            |
                             DAY ON TEST   | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6|            |
                                           | 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    50                                     | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3|      L     |
    MG/KG/DY                               | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |    2     2  2           3                                      2  2      |      7  2.3|
      Cranium, Hyperostosis                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  4.0|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |             +              +                                             |   5        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |    4                                2                          4         |      3  3.3|
      Hemorrhage                           |       2                       4                 2                        |      6  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 3  4  4                             3                          4         |     11  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2                                                                     |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6|            |
                             DAY ON TEST   | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6|            |
                                           | 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    50                                     | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3|      L     |
    MG/KG/DY                               | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X                       X         |      7     |
      Hydronephrosis                       |             2                                      2                     |      7  2.6|
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    | 2  3     3  2           3  2     3     2                    2  2  2      |     20  2.4|
      Nephropathy                          | 3  4  2  4  4           4  3     1     4     4  2        1     2  3  1  1|     31  2.6|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      2  3.5|
      Renal Tubule, Dilatation             |                                                                2  4      |      3  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |       2                                                                  |      1  2.0|
      Inflammation, Chronic                | 4                                                                        |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|             
                                           | 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    100                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2     2        3                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |       2  3                                2                 2  2  3     2|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |             X                                                        X   |             
      Hematopoietic Cell Proliferation     |                                        4        2        3               |             
      Infiltration Cellular, Mixed Cell    | 3  1           3                          2                              |             
      Necrosis, Focal                      |                                                 1        3               |             
      Hepatocyte, Hypertrophy              |                                                                      2   |             
      Hepatocyte, Vacuolization Cytoplasmic|             2                                                     3      |             
      Kupffer Cell, Hyperplasia            |          3                                                               |             
      Kupffer Cell, Pigmentation           |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +                                                                     |             
      Angiectasis                          |                                                                          |             
      Fat, Necrosis                        | 4  4                                                                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|             
                                           | 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    100                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         2  2     2                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Erosion                              |                                                       3                  |             
      Glands, Hyperplasia, Cystic          |                                                                      2  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +                                      +                                 |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1                                                  1  1      |             
      Inflammation, Chronic                |                                                                         2|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                        X     X     X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    3  3     3  3        3                                                |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                       2                          2         |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|             
                                           | 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    100                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 3  3  3  4     2     2  1  1  1  3  3     1  3  3        3  1     2      |             
      Follicular Cell, Hyperplasia         |          1                       1                                1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X     X  X  X  X  X  X  X     X                 X  X        X        X   |             
      Inflammation, Chronic                |    3  2     2     2  2        2  2        4     2        4               |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         4                                                |             
      Cyst                                 | X  X     X  X  X     X  X  X        X     X  X     X  X  X  X  X     X  X|             
      Hemorrhage                           |             3  3              2                    3     4  4            |             
      Thrombosis                           |                                                                          |             
      Corpus Luteum, Hyperplasia           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 4                        |             
      Hemorrhage                           |                2                                                         |             
      Thrombosis                           |                            X                    X                        |             
      Endometrium, Hyperplasia, Cystic     | 3  2  3  3  2              3  1     3     3     3           2  3  4  2  2|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Epithelium, Hyperplasia              |                      2           2                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        3  3  4     2     2     3  2  4        3        4  2     2  2  4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|             
                                           | 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    100                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +     +        +              +           +     +              +|             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Hemorrhage                           |                                                          3               |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                3                                                         |             
      Inguinal, Hyperplasia, Lymphoid      |                3                                   3                     |             
      Mediastinal, Hemorrhage              |                         4                                                |             
      Popliteal, Hyperplasia               |                4                                                         |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                3                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hemorrhage                           |                3                                         3               |             
      Hyperplasia, Lymphoid                | 2     2        3                    2     2              2              3|             
      Pigmentation                         |                               2                          2               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                      2   |             
      Hematopoietic Cell Proliferation     |                                     2                    3               |             
      Hemorrhage                           |             4           4           2                    2  3     2      |             
      Hyperplasia, Lymphoid                |                3  3              3  2                          2         |             
      Pigmentation                         |                            2     2  2                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3        3  3  2     1     1     2  2  4  1     4        4  1  1  1  2   |             
      Pigmentation                         |             3                 2                                      2   |             
      Lymphoid Follicle, Atrophy           |             3                                      2  4                  |             
      Lymphoid Follicle, Hyperplasia       | 2     2                                                                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3  3                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|             
                                           | 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    100                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2           2  2     2                                   2               |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                3     2                             3     3               |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                3        3                                            3   |             
      Hyperostosis                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          1               |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                +                                                     +   |             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         3                                                |             
      Fibrosis, Focal                      |                                                    2                     |             
      Hemorrhage                           |    1                       1                                         2   |             
      Hyperplasia, Lymphoid                |       2        4                                                         |             
      Infiltration Cellular, Histiocyte    | 3     2     4  2  2              3     3  1  4     4                    4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|             
                                           | 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    100                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1     2     2  2              3     3      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        2                             2   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Atrophy                              | 4                                                                        |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              3                           |             
      Hyperplasia, Focal                   |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Cyst                                 |                            X                       X                     |             
      Hydronephrosis                       |                2     2                             2                     |             
      Infarct                              |             4                                                            |             
      Infiltration Cellular, Mixed Cell    |       2                 2        2  3                    3        2  3   |             
      Nephropathy                          | 1  1  1  3  2  4  4  4  4  1  1  1  2     1     1  4  4     1  1  1  4  2|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Necrosis               |                                                 2                        |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7|            |
                                           | 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    100                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  A  +  +  +  +  +  +|  45        |
      Edema                                | 2                                                                        |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Ulcer                                |          4              3                                                |      2  3.5|
      Epithelium, Hyperplasia              |             3           2        2                    4        2         |     12  2.4|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|  46        |
      Epithelium, Hyperplasia              |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  M  M  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |             X                                                            |      1     |
      Cyst                                 |                      X                                                   |      1     |
      Eosinophilic Focus                   |                                                                         X|      3     |
      Hematopoietic Cell Proliferation     |       3              2                                                   |      5  2.8|
      Infiltration Cellular, Mixed Cell    |                   2                                                     1|      6  2.0|
      Necrosis, Focal                      |                   1              4  3                                    |      5  2.4|
      Hepatocyte, Hypertrophy              | 2                       2                                                |      3  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|          3                                                               |      3  2.7|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           |                                                       3                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7|            |
                                           | 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    100                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               | +                                   +  +              +                 +|   7        |
      Angiectasis                          |                                                                         3|      1  3.0|
      Fat, Necrosis                        | 2                                      4                                 |      4  3.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                2                                               2         |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  3.0|
      Glands, Hyperplasia, Cystic          | 2  2        3     2                       2                 3            |      8  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |             1           1                          2                     |      6  1.2|
      Inflammation, Chronic                |                                                                         2|      2  2.0|
      Mineralization                       |                                     1           1                        |      2  1.0|
      Thrombosis                           |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |             3     3  3     3                          3           3      |     11  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7|            |
                                           | 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    100                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2  2                             1                                 |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                         2                                                |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                      3                                                   |      1  3.0|
      Pars Intermedia, Hyperplasia         |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 | 2  2  2  1  3  3  3  3  2  3     3  2     2  3     3  1  2  2  3  3  2  2|     39  2.3|
      Follicular Cell, Hyperplasia         |                                                       1              3   |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X     X        X  X  X              X  X  X        X  X  X           X|     25     |
      Inflammation, Chronic                |    2        2        3                             4  3     2           3|     17  2.6|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                3                       4                       4         |      4  3.8|
      Cyst                                 | X  X  X  X     X  X  X     X     X  X  X     X     X     X  X  X  X  X  X|     37     |
      Hemorrhage                           |                                                                   3      |      7  3.1|
      Thrombosis                           |                X                                                  X      |      2     |
      Corpus Luteum, Hyperplasia           |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                         3           4                             4      |      4  3.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7|            |
                                           | 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    100                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Thrombosis                           |                                     X                                    |      3     |
      Endometrium, Hyperplasia, Cystic     |    2     4     3  2  3  3        3     4              2  4  3  2  2  2   |     29  2.7|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3     4     3        4  3  3     2        3        4  3     2  3  2  2  2|     30  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +              +  +  +     +  +              +  +        +         |  16        |
      Hematopoietic Cell Proliferation     |                      3                                                   |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |       3                                                                  |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                    4                     |      2  3.5|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  3.0|
      Mediastinal, Hemorrhage              |                                                                3         |      2  3.5|
      Popliteal, Hyperplasia               |                                                                          |      1  4.0|
      Renal, Hemorrhage                    |                         2                                                |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                         2                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                           2                              |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                         2|      2  1.5|
      Hemorrhage                           |             3           3                 1                              |      5  2.6|
      Hyperplasia, Lymphoid                |       2        2                             4     3  4  2  2     2  2  2|     17  2.4|
      Pigmentation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |                               2           3                              |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7|            |
                                           | 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    100                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Ectasia                              |                                                       3                  |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hemorrhage                           |             3           3                                   2            |      9  2.8|
      Hyperplasia, Lymphoid                |                                              2        4     2        3   |      9  2.7|
      Pigmentation                         |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2  1  4        2     2           1  3  2  2        3  4  2  3  4  2     2|     32  2.3|
      Pigmentation                         | 2           3  2  2        2  3           2                 2           2|     12  2.3|
      Lymphoid Follicle, Atrophy           |                               3           2                              |      5  2.8|
      Lymphoid Follicle, Hyperplasia       |                                                    2     2  2     3  2   |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Atrophy                              | 3           3                 2                                          |      5  2.8|
      Hemorrhage                           |                                           3                             2|      2  2.5|
      Hyperplasia, Lymphoid                |                                              3                       3   |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       3              1  2                                                |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Edema                                | 3                                         3        3                     |      7  2.9|
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Ulcer                                |                      4                                                   |      1  4.0|
      Epidermis, Hyperplasia               |                      4     3     1                                       |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 1           2              2  2           3        2                     |      9  2.3|
      Hyperostosis                         |                                                                   2      |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7|            |
                                           | 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    100                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Skeletal Muscle                         |                                                    +                     |   1        |
      Inflammation, Chronic                |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                +         |   3        |
      Atrophy                              |                                                                2         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                        X                                 |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |             3                                      3  2                  |      4  2.8|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hemorrhage                           |                         2        1                 2                     |      6  1.5|
      Hyperplasia, Lymphoid                |                         2                                                |      3  2.7|
      Infiltration Cellular, Histiocyte    |                2        2  4           3     3     4  2     3  1     4   |     21  2.9|
      Alveolar Epithelium, Hyperplasia     |                2                       1              2                 2|     10  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             3                             2           2              2  1|      7  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
      Atrophy                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7|            |
                                           | 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    100                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                               3                                          |      1  3.0|
      Cyst                                 |                      X                             X        X            |      5     |
      Hydronephrosis                       |                         3                 4                              |      5  2.6|
      Infarct                              |                                     4                                2   |      3  3.3|
      Infiltration Cellular, Mixed Cell    |       2     2                    2     2  3  2           3              2|     15  2.3|
      Nephropathy                          | 4  1  3  2  4  1        2  1  4  1  2  1  4     4  3     3  1     1  1   |     41  2.2|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |          2                          4                                    |      2  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                       3     2            |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|             
                             DAY ON TEST   | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|             
                                           | 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    200                                    | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |          2  2                                               2            |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                4         |             
      Cyst                                 |                                                 X                        |             
      Eosinophilic Focus                   |                                                                X         |             
      Hematopoietic Cell Proliferation     |          3                                      3                        |             
      Hyperplasia, Lymphoid                |                      2           2                          2            |             
      Infiltration Cellular, Mixed Cell    |    3        4                 2     2     2                             1|             
      Necrosis, Focal                      |                                                                          |             
      Hepatocyte, Hypertrophy              | 3                                                                        |             
      Kupffer Cell, Hyperplasia            |                                                          3               |             
      Kupffer Cell, Pigmentation           |    2        3                                            3              2|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                     +           +              +         |             
      Hemorrhage                           |                                     4                                    |             
      Fat, Necrosis                        |                                                 4              4         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Acinus, Cytoplasmic Alteration       |                                                          3     3         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|             
                             DAY ON TEST   | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|             
                                           | 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    200                                    | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               2                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      3                                                   |             
      Epithelium, Hyperplasia              |          3                                                               |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia, Cystic          |    2     2              2                    3  3        1     2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                  2                                       |             
      Inflammation, Chronic                |                                     2                                    |             
      Mineralization                       |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    3              3                             3  3                     |             
      Capsule, Hyperplasia                 |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                            2  2           2            |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                   2      |             
      Pars Distalis, Cyst                  |                                  X                 X                     |             
      Pars Distalis, Hyperplasia, Focal    | 3                                                                 2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|             
                             DAY ON TEST   | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|             
                                           | 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    200                                    | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Degeneration, Cystic                 | 3  3  1  2  1                 2  1  1  2  2  3  2        2  2  2  1  1   |             
      Follicular Cell, Hyperplasia         |          2                          1                 2           1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X     X              X  X  X  X  X  X              X        X            |             
      Infiltration Cellular, Lymphocyte    |                                                 3                        |             
      Inflammation, Chronic                | 2     2                       3  2  3  4  2        3                    4|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 4                                4        3                              |             
      Cyst                                 |    X     X     X     X  X  X  X  X  X  X  X     X  X  X  X  X     X     X|             
      Hemorrhage                           | 3                                         2     2                       2|             
      Thrombosis                           |                                                                          |             
      Bilateral, Cyst                      |                                                                          |             
      Corpus Luteum, Hyperplasia           |                               3                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 3  2        3           2     4  3  3  3  4  4     3  2  2  2     2  3  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     4  3  2  2     2        2  3  2  2  2  2           2     4  3      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +  +        +        +  +                                +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                3         |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                               4                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |    3                                                                     |             
      Popliteal, Hyperplasia, Lymphoid     |                               3                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|             
                             DAY ON TEST   | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|             
                                           | 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    200                                    | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              4                           |             
      Hematopoietic Cell Proliferation     |    2                                   2                 2               |             
      Hemorrhage                           | 2  3                                                                     |             
      Hyperplasia, Lymphoid                |    3        2           2     4  2           3           2     3        2|             
      Pigmentation                         | 2  2                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
      Ectasia                              |    3        3                 4                                          |             
      Hematopoietic Cell Proliferation     |                               3                                          |             
      Hemorrhage                           |    1           3                       2                                2|             
      Hyperplasia, Lymphoid                |    2        3                 3  2                    2     3  2         |             
      Pigmentation                         |                                        2                                2|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                3         |             
      Hematopoietic Cell Proliferation     |          2  2  4  2     3  3  3  4  1  3  2  4           2  1     3      |             
      Pigmentation                         | 2  2                 2        2              2  2        2     2         |             
      Lymphoid Follicle, Atrophy           | 2                                                        2     3        3|             
      Lymphoid Follicle, Hyperplasia       |    2        2        3        3  2                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                | 2           4                 3                    2        3            |             
      Thrombosis                           |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                3                             2  2      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                X         |             
      Edema                                |       3              3  2                                                |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |          3                                            3  2     4         |             
      Epidermis, Hyperplasia               |          3                                            2        3         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|             
                             DAY ON TEST   | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|             
                                           | 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    200                                    | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    3              2  3  2                                                |             
      Hyperostosis                         |                                              3                           |             
      Myelofibrosis                        |          3                                                               |             
      Femur, Hyperostosis                  |                                        4                                 |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                               +                          +     +         |             
      Atrophy                              |                               2                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                                         |             
      Necrosis                             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   3                                                      |             
      Hemorrhage                           |                                  1        3                              |             
      Hyperplasia, Lymphoid                |             2                                               4            |             
      Infiltration Cellular, Histiocyte    | 4  2  2  3     3              4           4     4           4            |             
      Infiltration Cellular, Mixed Cell    |                               2                                          |             
      Inflammation, Chronic                |                   3                                                      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       1        1         |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|             
                             DAY ON TEST   | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|             
                                           | 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    200                                    | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                       X  X                          X                 X|             
      Hydronephrosis                       |    3  2              2                                                   |             
      Infarct                              |                               3                                3         |             
      Infiltration Cellular, Mixed Cell    |    4              3  3  3     2  2           2              2  2         |             
      Nephropathy                          | 2  4  4  1        3  4  4        2  1  1        1     1  2  2  2     1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                            3                                         3   |             
      Renal Tubule, Dilatation             |                                                                2         |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           | 3              2                                                         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                2         |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6|                             |            |
                             DAY ON TEST   | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7|                             |            |
                                           | 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    200                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  39        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  39        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  38        |
      Edema                                |             3     3              2                                       |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Epithelium, Hyperplasia              |                                     2                                    |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  38        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 3        3                 3                                             |      5  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Infiltration Cellular, Mixed Cell    |    3        2                    2                                       |      9  2.3|
      Necrosis, Focal                      |          3        1     3                 2                              |      4  2.3|
      Hepatocyte, Hypertrophy              |                                  2                                       |      2  2.5|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           |    2        2                                                            |      6  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6|                             |            |
                             DAY ON TEST   | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7|                             |            |
                                           | 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    200                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Atrophy                              |    3                                                                     |      1  3.0|
      Acinus, Cytoplasmic Alteration       |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Edema                                |                                     2                                    |      2  2.5|
      Epithelium, Hyperplasia              |                   1                                                      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Glands, Hyperplasia, Cystic          |    2              2  4                                                   |     10  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                           3                              |      2  2.5|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  38        |
      Accessory Adrenal Cortical Nodule    |                3        3     3                                          |      7  3.0|
      Capsule, Hyperplasia                 |                               2                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  38        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Hyperplasia                          |                2                    2     2                              |      7  1.9|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                              |  37        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6|                             |            |
                             DAY ON TEST   | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7|                             |            |
                                           | 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    200                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |       X                                                                  |      3     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Degeneration, Cystic                 | 1     1              1  1  2        2     2                              |     24  1.7|
      Follicular Cell, Hyperplasia         |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Cyst                                 | X  X                       X  X                                          |     14     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic                | 2     4              4  2     2                                          |     14  2.8|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Angiectasis                          |                                                                          |      3  3.7|
      Cyst                                 |    X        X  X        X  X  X  X  X  X  X                              |     28     |
      Hemorrhage                           |                                           2                              |      5  2.2|
      Thrombosis                           |       X                                                                  |      1     |
      Bilateral, Cyst                      |       X                                                                  |      1     |
      Corpus Luteum, Hyperplasia           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Endometrium, Hyperplasia, Cystic     | 2  2                 2     3  2     3     3                              |     24  2.7|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6|                             |            |
                             DAY ON TEST   | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7|                             |            |
                                           | 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    200                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Hyperplasia                          | 3  4  3  3              2        3     2                                 |     22  2.6|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +                                                      |  12        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |       2                                                                  |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Popliteal, Hyperplasia, Lymphoid     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Ectasia                              |    3                                      2                              |      3  3.0|
      Hematopoietic Cell Proliferation     |                               2                                          |      4  2.0|
      Hemorrhage                           | 2     2                             1                                    |      5  2.0|
      Hyperplasia, Lymphoid                |                               3                                          |     10  2.6|
      Pigmentation                         | 2                                   3                                    |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      3  3.3|
      Hematopoietic Cell Proliferation     |                                  2  3                                    |      3  2.7|
      Hemorrhage                           | 2                       3        3  2  3                                 |      9  2.3|
      Hyperplasia, Lymphoid                |                                  2  2     3                              |     10  2.4|
      Pigmentation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 4  3  1  4        4  1  4  3  1  1     3                                 |     26  2.6|
      Pigmentation                         |                               2     2                                    |     10  2.0|
      Lymphoid Follicle, Atrophy           |    3  3                                                                  |      6  2.7|
      Lymphoid Follicle, Hyperplasia       |                                     3                                    |      6  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +                              |  36        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6|                             |            |
                             DAY ON TEST   | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7|                             |            |
                                           | 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    200                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              |       3                 2                                                |      2  2.5|
      Hyperplasia, Lymphoid                | 2                                         3                              |      7  2.7|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Hyperplasia                          | 2  2                                                                     |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Edema                                |       4  2        2                                                      |      6  2.7|
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Ulcer                                |                   3                                                      |      5  3.0|
      Epidermis, Hyperplasia               |    2                                                                     |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Fibrous Osteodystrophy               |       2                          2                                       |      6  2.3|
      Hyperostosis                         |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
      Femur, Hyperostosis                  |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                   +              +                                       |   5        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6|                             |            |
                             DAY ON TEST   | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7|                             |            |
                                           | 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    200                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                               3  2                                       |      4  2.8|
      Infiltration Cellular, Histiocyte    |    4                       3  4                                          |     12  3.4|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                        2                                 |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                3        2     3                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   1        |
      Atrophy                              |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Hyperplasia, Focal                   |                                           2                              |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Cyst                                 | X                    X                                                   |      7     |
      Hydronephrosis                       |                         3        4                                       |      5  2.8|
      Infarct                              |                                                                          |      2  3.0|
      Infiltration Cellular, Mixed Cell    | 2        2           3           3        2                              |     14  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6|                             |            |
                             DAY ON TEST   | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7|                             |            |
                                           | 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |      A     |
    200                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |      L     |
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Nephropathy                          | 3  1  4  3        3  2           4     1  1                              |     26  2.2|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                         4                                                |      3  3.3|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |          2                                                               |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  40        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|             
                             DAY ON TEST   | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|             
                                           | 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             2            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               2              3           2  3  2     2   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               3                                         3|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                            2  2                    2                     |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                2                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                   X      |             
      Hematopoietic Cell Proliferation     |                         3                 2              4  2  3  2      |             
      Infiltration Cellular, Mixed Cell    |                   2                 2  2           2                    2|             
      Necrosis, Focal                      |                   2     1                                                |             
      Regeneration                         |                                                                          |             
      Hepatocyte, Hypertrophy              |                         3                                               2|             
      Hepatocyte, Vacuolization Cytoplasmic|                3                                      3                  |             
      Kupffer Cell, Hyperplasia            |       2                                      2                           |             
      Kupffer Cell, Pigmentation           |       2                 2              2     2                          2|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +                 +                                             |             
      Fat, Necrosis                        |          4                 4                                             |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|             
                             DAY ON TEST   | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|             
                                           | 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              2                           |             
      Acinus, Cytoplasmic Alteration       |       4                                                        3        3|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           2  3                           |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         2           3                                    |             
      Erosion                              |    2                                                                     |             
      Epithelium, Hyperplasia              |    1  2        1                                      2                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     3                       2            |             
      Infiltration Cellular, Mixed Cell    |                                                    1                     |             
      Glands, Hyperplasia, Cystic          |    2                                               3                 2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                   1     2|             
      Inflammation, Chronic                |                                              1                           |             
      Mineralization                       |       2  3                                                               |             
      Thrombosis                           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    3                                                     3               |             
      Hyperplasia, Diffuse                 |                2                                                         |             
      Hypertrophy, Focal                   |                                                                          |             
      Capsule, Hyperplasia                 |                                           3        2                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              1        2  2        2  2  2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|             
                             DAY ON TEST   | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|             
                                           | 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                              2                           |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2     2  1           2  3  2  2  3  3  3  3  2  3     2           1  2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X                    X  X           X  X        X                     |             
      Inflammation, Chronic                | 2  2                    2              2  3        3           4  4  4   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                         3|             
      Angiectasis                          |             4                          2  4                              |             
      Cyst                                 | X        X  X  X  X        X  X  X  X  X  X        X  X  X  X  X     X   |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                           X                              |             
      Corpus Luteum, Hyperplasia           |                         2                                                |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Infiltration Cellular, Histiocyte    |                                                 3                        |             
      Inflammation, Chronic                |                                     3                                    |             
      Thrombosis                           |    X                                                                     |             
      Endometrium, Hyperplasia, Cystic     |    2        2     2           2  2  3  2  3        3  3                 2|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|             
                             DAY ON TEST   | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|             
                                           | 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2  2  2     2  3  2     2  3  4  4  3  2        4  4  4  4  3   |             
      Myelofibrosis                        |                                              3                           |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                       +     +                       +  +        +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                   4      |             
      Pigmentation                         |                                                                         2|             
      Iliac, Hemorrhage                    |                                                                          |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                                                      2   |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                   4  3   |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3  2  2                    3                                    |             
      Ectasia                              |                                                                4  4      |             
      Hematopoietic Cell Proliferation     |                1                                               2     2   |             
      Hemorrhage                           |                1        3  2        1                                3   |             
      Hyperplasia, Lymphoid                |                                                 2     2                  |             
      Hyperplasia, Plasma Cell             |                                                                3  4      |             
      Pigmentation                         |                         2  2                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2  3  2                          3        2                           |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |             2                             2              2        2  2   |             
      Hemorrhage                           |             2  4        1     1        1           2                 3  3|             
      Hyperplasia, Lymphoid                |                                                    3           3  2  2   |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2     4  4     3  2  2  1           2  4  3           4  4  4  4  4  3|             
      Pigmentation                         |    2  3        2                    2  3                    2           3|             
      Lymphoid Follicle, Atrophy           |       2  3                          3                       3            |             
      Lymphoid Follicle, Hyperplasia       |                                                                3     2   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|             
                             DAY ON TEST   | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|             
                                           | 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Atrophy                              |       4  3           2                                      2            |             
      Hemorrhage                           |                4                    2        3                           |             
      Hyperplasia, Lymphoid                |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2           3                          2  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |          X                                               X               |             
      Edema                                |                      3              3        3              4            |             
      Inflammation, Chronic                |                                                                      4   |             
      Ulcer                                |                                                                4  4      |             
      Epidermis, Hyperplasia               |                                                                4  4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    3  1                                      3              3            |             
      Femur, Callus                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |    +  +                             +                                    |             
      Thrombosis                           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |       +     +                       +     +  +                 M     +   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|             
                             DAY ON TEST   | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|             
                                           | 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Edema                                |    4  1  3                                                               |             
      Hemorrhage                           |       2  1           3                 3                       2        1|             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Infiltration Cellular, Histiocyte    |          3              1  2  2        4  3        2                     |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic                |    3                                   4                                 |             
      Alveolar Epithelium, Hyperplasia     |                2                                   2                     |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          2               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3                                                               |             
      Cyst                                 |                               X                 X        X               |             
      Hydronephrosis                       |                3                    2                       2            |             
      Infiltration Cellular, Mixed Cell    |    2           3           2              2  3     2        2        2  2|             
      Metaplasia, Osseous                  |                   2                                                      |             
      Nephropathy                          |    4  4  3  1  3     4  1  1  1     4     1  4  2  2     1  4     1  3  4|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |             3                 2                                          |             
      Renal Tubule, Pigmentation           |             3                             3                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2                                3                        |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|                       |            |
                             DAY ON TEST   | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7|                       |            |
                                           | 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1|                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                       |      A     |
    300                                    | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                       |      L     |
    MG/KG/DY                               | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  39        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Edema                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  40        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  40        |
      Edema                                |                               1                 3                        |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Erosion                              |                                                                          |      2  3.0|
      Ulcer                                |                                                 3                        |      1  3.0|
      Epithelium, Hyperplasia              |    2  2  2        2           2                 2                        |      9  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  40        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  40        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Basophilic Focus                     |                               X                                          |      1     |
      Eosinophilic Focus                   |    X                          X                                          |      3     |
      Hematopoietic Cell Proliferation     |                         2  2                                             |      8  2.5|
      Infiltration Cellular, Mixed Cell    |    2  3                       2           2                              |      9  2.1|
      Necrosis, Focal                      |             3  3                       1  2                              |      6  2.0|
      Regeneration                         |                         3                                                |      1  3.0|
      Hepatocyte, Hypertrophy              |                                                                          |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  3.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      2  2.0|
      Kupffer Cell, Pigmentation           |                                           2                              |      6  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|                       |            |
                             DAY ON TEST   | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7|                       |            |
                                           | 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1|                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                       |      A     |
    300                                    | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                       |      L     |
    MG/KG/DY                               | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                          +                                 |   5        |
      Fat, Necrosis                        |             3                                                            |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                        |  41        |
      Edema                                |                                                                          |      1  2.0|
      Acinus, Cytoplasmic Alteration       |    3                                                                     |      4  3.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Hyperplasia, Lymphoid                |    2              2                                                      |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Edema                                |                                  2           2                           |      4  2.3|
      Erosion                              |                1                                                         |      2  1.5|
      Epithelium, Hyperplasia              |                                                                          |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Edema                                |                                                                          |      2  2.5|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
      Glands, Hyperplasia, Cystic          |                   4           2              2                           |      6  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Cardiomyopathy                       |                                                                          |      2  1.5|
      Inflammation, Chronic                |       3                                                                  |      2  2.0|
      Mineralization                       |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Accessory Adrenal Cortical Nodule    | 3                 3        3              3                              |      6  3.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|                       |            |
                             DAY ON TEST   | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7|                       |            |
                                           | 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1|                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                       |      A     |
    300                                    | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                       |      L     |
    MG/KG/DY                               | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy, Focal                   |                            3                                             |      1  3.0|
      Capsule, Hyperplasia                 |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +                        |  41        |
      Hyperplasia                          |          1  2     2           2                                          |     10  1.8|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +                        |  36        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Pars Distalis, Angiectasis           |    3              2                                                      |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |                   1        3                 2                           |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Degeneration, Cystic                 |    3  3  3  3     3  3  2        3  1  2  3  2  2                        |     29  2.4|
      Follicular Cell, Hyperplasia         |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Cyst                                 |          X  X                 X           X     X                        |     12     |
      Inflammation, Chronic                |    4        3        3        2           2  2  3                        |     16  2.8|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Angiectasis                          |             2                                                            |      4  3.0|
      Cyst                                 |       X  X  X  X  X     X  X     X     X  X  X  X                        |     29     |
      Hemorrhage                           |                   3     3  2           3                                 |      4  2.8|
      Thrombosis                           |                                                                          |      1     |
      Corpus Luteum, Hyperplasia           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|                       |            |
                             DAY ON TEST   | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7|                       |            |
                                           | 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1|                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                       |      A     |
    300                                    | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                       |      L     |
    MG/KG/DY                               | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                       |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Angiectasis                          |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |    2     4  4     4     2  4  3  3     2  1     3                        |     22  2.6|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  41        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Hyperplasia                          | 2  3  3  2     4     2  2  3                    3                        |     26  2.8|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +  +     +        +  +        +  +        +                        |  16        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Iliac, Hemorrhage                    |                                                 3                        |      1  3.0|
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  3.5|
      Lumbar, Hyperplasia, Lymphoid        |       3                                                                  |      1  3.0|
      Mediastinal, Hemorrhage              |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Atrophy                              |                                                                          |      4  2.5|
      Ectasia                              |                                                                          |      2  4.0|
      Hematopoietic Cell Proliferation     |          2  2                          2                                 |      6  1.8|
      Hemorrhage                           |                   3           2                                          |      7  2.1|
      Hyperplasia, Lymphoid                |    2     2                                                               |      4  2.0|
      Hyperplasia, Plasma Cell             |       4                                                                  |      3  3.7|
      Pigmentation                         |          2        2           2  2                                       |      6  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|                       |            |
                             DAY ON TEST   | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7|                       |            |
                                           | 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1|                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                       |      A     |
    300                                    | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                       |      L     |
    MG/KG/DY                               | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                       |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Atrophy                              |                                                                          |      5  2.4|
      Ectasia                              |                                              3                           |      1  3.0|
      Hematopoietic Cell Proliferation     |          2        3                       3                              |      8  2.3|
      Hemorrhage                           |    3              2                       3                              |     11  2.3|
      Hyperplasia, Lymphoid                |                   2     3                    3                           |      7  2.6|
      Pigmentation                         |    2     2        2                       2                              |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Hematopoietic Cell Proliferation     |    1  3  3  3  3  3  3  3  4     2     3        3                        |     29  3.0|
      Pigmentation                         |    2     2           3        2  2                                       |     12  2.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      4  2.8|
      Lymphoid Follicle, Hyperplasia       |                      2  2        2        2  2                           |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Atrophy                              |                                                                          |      4  2.8|
      Hemorrhage                           |                                                                          |      3  3.0|
      Hyperplasia, Lymphoid                |    3                                                                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Hyperplasia                          |    2     1  1                                                            |      7  1.9|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Edema                                | 3                                                                        |      5  3.2|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Ulcer                                |       3                                                                  |      3  3.7|
      Epidermis, Hyperplasia               |       4                                                                  |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|                       |            |
                             DAY ON TEST   | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7|                       |            |
                                           | 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1|                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                       |      A     |
    300                                    | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                       |      L     |
    MG/KG/DY                               | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                       |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Fibrous Osteodystrophy               |                                                                          |      4  2.5|
      Femur, Callus                        |                            X                                             |      1     |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   4        |
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   6        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Edema                                |                                                                          |      3  2.7|
      Hemorrhage                           |       3                                      2                           |      8  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                   4           3           4                              |     10  2.8|
      Infiltration Cellular, Mixed Cell    |                                           3                              |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  3.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Inflammation, Chronic                |    2              2     1                                                |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6|                       |            |
                             DAY ON TEST   | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7|                       |            |
                                           | 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1|                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      O     |
   SWISS MICE FEMALE                       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                       |      T     |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                       |      A     |
    300                                    | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                       |      L     |
    MG/KG/DY                               | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|                       |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |       +                                M                                 |   2        |
      Cataract                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  41        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Amyloid Deposition                   | 3                                                                        |      2  3.0|
      Cyst                                 | X                                               X                        |      5     |
      Hydronephrosis                       |                                                                          |      3  2.3|
      Infiltration Cellular, Mixed Cell    |    2  2     1     2     2                 2                              |     15  2.1|
      Metaplasia, Osseous                  |                            2                                             |      2  2.0|
      Nephropathy                          | 3  3  1  1  1  1  1     2  3  1        2  2  1  1                        |     33  2.2|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                3                                                         |      3  2.7|
      Renal Tubule, Pigmentation           |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                        |  42        |
      Hyperplasia, Lymphoid                |                   2                                                      |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|             
                             DAY ON TEST   | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|             
                                           | 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0                                      | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  A  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Edema                                |    2                    2  2     2                                   2   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Epithelium, Hyperplasia              |                                        2                             2   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Epithelium, Hyperplasia              |                      2     2                                             |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Basophilic Focus                     | X                                                                        |             
      Clear Cell Focus                     |                                                       X                  |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |          1  3  2  1           2        2                    2            |             
      Infiltration Cellular, Mixed Cell    | 2  1        2                                                           2|             
      Necrosis, Focal                      |       1              1     4                                             |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Hypertrophy              | 2  2  1           3  2     2                       2  3     2        2  2|             
      Hepatocyte, Vacuolization Cytoplasmic|                      2                                                   |             
      Kupffer Cell, Hyperplasia            |                            3                                3            |             
      Kupffer Cell, Pigmentation           |                                     2                                    |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|             
                             DAY ON TEST   | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|             
                                           | 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0                                      | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphoid      |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  2                                       |             
      Ulcer                                |                                  2                                       |             
      Epithelium, Hyperplasia              |                                                                         1|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Erosion                              |                                  3                                       |             
      Glands, Hyperplasia, Cystic          | 2     3                    2        2                 3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
      Inflammation, Chronic                |                                                                4         |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Cardiomyopathy                       |       2                             2                                   2|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation                         |    2                                                                     |             
      Thrombosis                           |                                     X                             X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                           3  3  3        3               |             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|             
                             DAY ON TEST   | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|             
                                           | 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0                                      | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hypertrophy, Focal                   |                                           2                              |             
      Capsule, Hyperplasia                 |                                                          3               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1  1           2              1  3  3     4            |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Degeneration, Cystic                 |             2  3  3  2     2                    2  2  2  3           3  2|             
      Follicular Cell, Hyperplasia         |                                        1                 1              1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                         3|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                X   |             
      Inflammation, Chronic                | 4  4  2     4              2        3              2                     |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                             4        3  3  3  3   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   3                                                      |             
      Inflammation, Chronic                |                                                                3     3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|             
                             DAY ON TEST   | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|             
                                           | 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0                                      | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 1                          2                                            2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  4  3  4  4  4  4  2  2  3  4  2  2  4  2  4  4  2  3  4  3  4  4  4  4|             
      Infiltration Cellular, Mast Cell     |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +  +  +                             +  +              +        +|             
      Hematopoietic Cell Proliferation     |             2  3                             3                           |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Hyperplasia, Plasma Cell             |             3  3                             4                           |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |          1     3                                                         |             
      Inguinal, Hyperplasia, Plasma Cell   |          3                                                               |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                3         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             4                                                            |             
      Hematopoietic Cell Proliferation     |             2  2                                                         |             
      Hyperplasia, Lymphoid                |       3  2  2              2                                2            |             
      Hyperplasia, Plasma Cell             |             3  4  3           3              3  3  3                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |             2  2  3  3        2              3  2                        |             
      Hemorrhage                           |       2                                                  2               |             
      Hyperplasia, Lymphoid                |    2  2        2  2        3                 2  2        2               |             
      Infiltration Cellular, Histiocyte    |                                  2                                       |             
      Necrosis                             |    3                                                                     |             
      Pigmentation                         |                                  2                                       |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|             
                             DAY ON TEST   | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|             
                                           | 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0                                      | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     2  3  4  4  4     1  4  4  4     4     4  4           4  3  3  3  3|             
      Pigmentation                         |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                  3  4                             3      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2     2  3     2           2        3     3     3|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  2                                       |             
      Ulcer                                |          4  4  4  4           4        4     4  4        2              4|             
      Epidermis, Hyperplasia               | 1           3  4  4           4              4  4        2              4|             
      Epidermis, Inflammation              |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Hemorrhage                           |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                   +  +              +           +                        |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Infiltration Cellular, Mast Cell     |    3                                                                     |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|             
                             DAY ON TEST   | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|             
                                           | 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0                                      | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                     X                                    |             
      Hemorrhage                           |                   1  2  2                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2                 3     2  2     4                                    |             
      Inflammation, Chronic                |    2                                3                                    |             
      Thrombosis                           |                                                                   X      |             
      Alveolar Epithelium, Hyperplasia     |                   2        1                                             |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                     X                                    |             
      Inflammation, Chronic                |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation                         |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Cyst                                 | X  X  X              X     X  X  X  X  X  X        X  X  X              X|             
      Hydronephrosis                       | 2  2  2     1  1           1        3  2     1  2  2  2  2  2  3  3  3   |             
      Infarct                              |                                        2                                 |             
      Infiltration Cellular, Mixed Cell    | 2  2  2                 2  2                                         2   |             
      Inflammation, Chronic                |             2                                                            |             
      Inflammation, Suppurative            |                                                    2        4  4  4      |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 2     2  1        1  1  3  3  2  2  4  2  1     1  1  2  1           3  2|             
      Renal Tubule, Necrosis               |                                  1                                       |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                               M                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|             
                             DAY ON TEST   | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|             
                                           | 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0                                      | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
   Urethra                                 |                                                                          |             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             2  2  3  3   |             
      Transitional Epithelium, Hyperplasia |                2                                            2     3  3   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4|            |
                             DAY ON TEST   | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8|            |
                                           | 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|      A     |
    0                                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1|      L     |
    MG/KG/DY                               | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |       2     2  2                                         2  2  2  2  2   |     13  2.0|
      Infiltration Cellular, Lymphocyte    |                                           4                              |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Epithelium, Hyperplasia              |                                                       3                  |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Epithelium, Hyperplasia              |                   2                                                  3   |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                             X            |      2     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   | X                                            X                       X   |      3     |
      Hematopoietic Cell Proliferation     | 2                                               2                        |      9  1.9|
      Infiltration Cellular, Mixed Cell    |       2                                2     2     1           3  3      |     10  2.0|
      Necrosis, Focal                      |             4                 4  4                             1     1   |      8  2.5|
      Centrilobular, Necrosis              |                            3                                      1      |      2  2.0|
      Hepatocyte, Hypertrophy              |    3                                               2  2  2               |     15  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4|            |
                             DAY ON TEST   | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8|            |
                                           | 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|      A     |
    0                                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1|      L     |
    MG/KG/DY                               | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      2  3.0|
      Kupffer Cell, Pigmentation           |                                                                2         |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                    +                     |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                   3      |      1  3.0|
      Acinus, Cytoplasmic Alteration       |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                       3                  |      1  3.0|
      Infiltration Cellular, Lymphoid      |                         2                                                |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                       2                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                      1   |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                  2                                       |      2  2.5|
      Glands, Hyperplasia, Cystic          |                1              2                                2     3   |      9  2.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Cardiomyopathy                       | 1  1              2     3  3              2        2           1     2   |     12  1.9|
      Inflammation, Chronic                |                                                             1            |      1  1.0|
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4|            |
                             DAY ON TEST   | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8|            |
                                           | 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|      A     |
    0                                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1|      L     |
    MG/KG/DY                               | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Thrombosis                           |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    3     3              3                                      3         |      8  3.0|
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Hyperplasia, Focal                   |                                     2                 3                  |      2  2.5|
      Hypertrophy, Focal                   |                2                                   3     2     3     3   |      6  2.5|
      Capsule, Hyperplasia                 |                                                       2                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           2                              |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  1                                      2  2        1  1     2  2      |     15  1.9|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                   2      |      1  2.0|
      Degeneration, Cystic                 |    3  3  3  1     3     1  2  3  3  2  3  3  2  3  2  1  1     1         |     29  2.3|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4|            |
                             DAY ON TEST   | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8|            |
                                           | 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|      A     |
    0                                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1|      L     |
    MG/KG/DY                               | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic                |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         X  X                                   X     X   |      6     |
      Inflammation, Chronic                |                         2  2           2                       2         |     11  2.6|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                1                       2                                 |      8  2.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                        3                                 |      2  3.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |                                        3                                 |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4  4  3                 2  2  4  2  3  4  3  3  4  3  2     3     2  3  4|     43  3.2|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +              +  +        +                                         +|  12        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      3  3.3|
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |    2                                                                     |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  2.0|
      Inguinal, Hyperplasia, Plasma Cell   |    3                                                                     |      2  3.0|
      Mediastinal, Hemorrhage              |                               2                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                               3                                          |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4|            |
                             DAY ON TEST   | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8|            |
                                           | 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|      A     |
    0                                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1|      L     |
    MG/KG/DY                               | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |    3                                                                     |      2  3.5|
      Hematopoietic Cell Proliferation     | 2  2                    2                 2     3                        |      7  2.1|
      Hyperplasia, Lymphoid                |    2                                   2        2        2     3     2   |     11  2.2|
      Hyperplasia, Plasma Cell             | 2  3                                      2  3                           |     11  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Ectasia                              |                                              3           3               |      2  3.0|
      Hematopoietic Cell Proliferation     | 2  2                    2                    3  3                        |     12  2.4|
      Hemorrhage                           |                            3  2  3     3           1                     |      7  2.3|
      Hyperplasia, Lymphoid                | 3                          2     2           3        2  2           2   |     15  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Hematopoietic Cell Proliferation     | 4  4                    2  4  4  4  3     4  4  4           3     1     4|     31  3.4|
      Pigmentation                         |                         2              2                                 |      2  2.0|
      Lymphoid Follicle, Atrophy           |                                     3                                    |      4  3.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 2           3              2  3  2  4        3                           |     15  2.6|
      Cyst                                 |                                        X                             X   |      2     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                | 2  4        2     2  3     3     3                                4     4|     10  2.9|
      Ulcer                                | 4  4                                         4  4                        |     14  3.9|
      Epidermis, Hyperplasia               | 4  4                                         4  3                        |     13  3.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4|            |
                             DAY ON TEST   | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8|            |
                                           | 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|      A     |
    0                                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1|      L     |
    MG/KG/DY                               | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Epidermis, Inflammation              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |    +                          +                                   +      |   7        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                             X            |      1     |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
      Necrosis                             |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           |                                                                1  2      |      5  1.6|
      Hyperplasia, Lymphoid                |                         3                                                |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1                             2        4  2  2                       1   |     12  2.3|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                         2              2  1           1                  |      6  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Chronic                | 1        3     2                                   2                     |      5  2.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4|            |
                             DAY ON TEST   | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8|            |
                                           | 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|      A     |
    0                                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1|      L     |
    MG/KG/DY                               | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |          3                    2                                          |      2  2.5|
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                   2                 3                             3      |      3  2.7|
      Cyst                                 |    X     X     X  X        X  X     X              X  X  X     X  X  X   |     27     |
      Hydronephrosis                       |    2        2        2  3  2           2  2        2  2     1  3     3  2|     30  2.1|
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |    2                       2                                   2         |      9  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      4  3.5|
      Metaplasia, Osseous                  |                                                                      2   |      1  2.0|
      Nephropathy                          | 1  2  2  1  1  1        2  2  1  1  1  2  2  1  1  2  3  2     2  1  3  2|     40  1.8|
      Renal Tubule, Necrosis               |                               2        1                                 |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                        +                                 |   1        |
      Angiectasis                          |                                        4                                 |      1  4.0|
      Inflammation, Chronic                |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      4  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|             
                             DAY ON TEST   | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|             
                                           | 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    50                                     | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG/DY                               | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    2              2  2        2  2                                       |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              | 2     2                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                   X                                                      |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |    X                                X                                    |             
      Hematopoietic Cell Proliferation     |                            1           4                          3     3|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mixed Cell    |             3     2  2           2              2                        |             
      Necrosis, Focal                      |                               2              3        4  2     4         |             
      Hepatocyte, Hypertrophy              | 2           3        3        2     3        2  2        2     2         |             
      Hepatocyte, Vacuolization Cytoplasmic|                                     2                                    |             
      Kupffer Cell, Pigmentation           |             3                                                            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Hemorrhage                           |                         4                                                |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|             
                             DAY ON TEST   | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|             
                                           | 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    50                                     | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG/DY                               | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                2                                      2                  |             
      Glands, Hyperplasia, Cystic          |             2  2     2                       4     1                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
      Malformation                         | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             3                 2                                2         |             
      Inflammation, Chronic                |                                                                         2|             
      Mineralization                       |                4                                                  1      |             
      Thrombosis                           |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  3  3     3        3     3     3  3      |             
      Hyperplasia, Focal                   | 2  2                                2           2                        |             
      Hypertrophy, Focal                   |                   3                                                      |             
      Capsule, Hyperplasia                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        2     1  1                          2  4                        |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|             
                             DAY ON TEST   | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|             
                                           | 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    50                                     | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG/DY                               | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1  2  3     2  1  1           3  3           1  3     1     2  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                         +                                                |             
      Bilateral, Dilatation                |                         4                                                |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                         2|             
      Granuloma Sperm                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
      Inflammation, Chronic Active         |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X           X        X  X                 X                           |             
      Inflammation, Chronic                | 2  2                    4  2                                   2         |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                          4                                 |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |          3                                                               |             
      Inflammation, Chronic                |                         3                                                |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |    3                             2                                3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|             
                             DAY ON TEST   | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|             
                                           | 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    50                                     | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG/DY                               | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     4     3        3     4  2  2           4     4  2  3  2  2  4     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +                    +           +                          +      |             
      Hematopoietic Cell Proliferation     |                            3                                             |             
      Hyperplasia, Lymphoid                |                            4                                             |             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                 2     3                       3                        |             
      Hyperplasia, Plasma Cell             |             3              3                       3        2            |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3           2              3     3  3                                    |             
      Hematopoietic Cell Proliferation     |                                              2                    3      |             
      Hemorrhage                           | 1  2     1        2     3     2              2        3                  |             
      Hyperplasia, Lymphoid                |    3     2     3  2              3  3                          2        3|             
      Necrosis                             |                                                                         2|             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     4     3        4     4  3  2     4     4     4  2     2  2  4     3|             
      Pigmentation                         |                                                 2                        |             
      Lymphoid Follicle, Atrophy           |                                                       3  3           2   |             
      Lymphoid Follicle, Hyperplasia       |                                                             2  2         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      3                    3  2        3  3           3  3|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|             
                             DAY ON TEST   | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|             
                                           | 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    50                                     | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG/DY                               | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Edema                                |                                        3                                 |             
      Ulcer                                |             4              4                       4     4  3            |             
      Epidermis, Hyperplasia               |             4              4                             4  3            |             
      Subcutaneous Tissue, Edema           |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                      4   |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3                                                            |             
      Hemorrhage                           |                                        3                                 |             
      Infiltration Cellular, Histiocyte    |       2     4        3        2        3                       4  2      |             
      Inflammation, Chronic                |                      3                                                   |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          3     2  2                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|             
                             DAY ON TEST   | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|             
                                           | 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
    50                                     | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    MG/KG/DY                               | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X  X     X  X     X  X     X  X  X                 X     X  X         |             
      Hydronephrosis                       | 3  3     3     3     4  3     4                       3           2      |             
      Infiltration Cellular, Mixed Cell    | 2  2        2                 2                             2  2         |             
      Inflammation, Chronic                |                                                    2                     |             
      Metaplasia, Osseous                  | 2                                                                        |             
      Mineralization                       |                3                                                         |             
      Nephropathy                          | 3  3  2  1  2  3  1  2  1  1  3  3  1        1  1     2     1  3  1     1|             
      Renal Tubule, Dilatation             |          2                                                               |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                      +                                                   |             
      Dilatation                           |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Urethra                                 |             +  +                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Bulbourethral Gland, Cyst            |             X                                                            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5|            |
                             DAY ON TEST   | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6|            |
                                           | 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7|      A     |
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |       2  2        2  3                    3           2                  |     11  2.2|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                    2     2               |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                            3                                             |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   2                                                      |      1  2.0|
      Basophilic Focus                     |                                  X           X                       X   |      4     |
      Clear Cell Focus                     |                                              X                           |      1     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |    2                 3  2                                                |      7  2.6|
      Hemorrhage                           | 4                                                                        |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                              2                       2   |      7  2.1|
      Necrosis, Focal                      |    1                 3                          2        3               |      9  2.7|
      Hepatocyte, Hypertrophy              |       3              2  3                    3              2  3         |     15  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation           |                                                             3        2   |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   2        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5|            |
                             DAY ON TEST   | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6|            |
                                           | 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7|      A     |
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  4.0|
      Fat, Necrosis                        |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Cytoplasmic Alteration       |                                     4           3                        |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                             2            |      1  2.0|
      Erosion                              |                                                                          |      2  2.0|
      Glands, Hyperplasia, Cystic          | 4  1  2  2  1     2              2                          2            |     13  2.1|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Malformation                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    3  1                          1                          2            |      7  2.0|
      Inflammation, Chronic                |                                                       3     3  3     2   |      5  2.6|
      Mineralization                       |                                                                          |      2  2.5|
      Thrombosis                           |       X                    X                                      X      |      4     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          3     3                                                         |      9  3.0|
      Hyperplasia, Focal                   |                                                 2                        |      5  2.0|
      Hypertrophy, Focal                   |       3        4  2                          3                           |      5  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5|            |
                             DAY ON TEST   | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6|            |
                                           | 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7|      A     |
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Capsule, Hyperplasia                 |             3     3                                                      |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2           1                       2              2        2  3  2|     13  2.1|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                                                             X            |      2     |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |       2        1     3  2  2              1  2     3  3     2            |     23  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |    +                                                                     |   2        |
      Bilateral, Dilatation                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |             3                                               2            |      3  2.3|
      Granuloma Sperm                      |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                           +                              |   2        |
      Inflammation, Chronic Active         |                                           2                              |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          X           X   |      7     |
      Inflammation, Chronic                |    4                                            3  3  2  2           3   |     11  2.6|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5|            |
                             DAY ON TEST   | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6|            |
                                           | 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7|      A     |
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                      2   |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation, Chronic                |    2                                                        3            |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |             1                                   2           2           2|      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    4  3              4  4  4  3     2        2  3  4  4  3  3  2         |     29  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                         +                 +        +  +        +         |  10        |
      Hematopoietic Cell Proliferation     |                         2                                                |      2  2.5|
      Hyperplasia, Lymphoid                |                         3                          4                     |      3  3.7|
      Bronchial, Hyperplasia, Lymphoid     |                                                       3                  |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |       3                 3  4                                             |      7  3.0|
      Hyperplasia, Plasma Cell             |    3                    3  4                       3                 3   |      9  3.0|
      Pigmentation                         |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |             3                                3                           |      7  2.9|
      Hematopoietic Cell Proliferation     |                         3                                                |      3  2.7|
      Hemorrhage                           |       1  1                       3                    2  2  2            |     14  1.9|
      Hyperplasia, Lymphoid                |    3     3              2        2           3     2  3  2               |     16  2.6|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5|            |
                             DAY ON TEST   | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6|            |
                                           | 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7|      A     |
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2  3  2  1  1        4  4  4     2                 4  3  4     3  3      |     29  3.0|
      Pigmentation                         |       2                                                              2   |      3  2.0|
      Lymphoid Follicle, Atrophy           |                                     2                                   3|      5  2.6|
      Lymphoid Follicle, Hyperplasia       |       2  2  2                                2                           |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  45        |
      Atrophy                              | 2                          4  2     4                             3      |     12  2.9|
      Cyst                                 |                                                                      X   |      1     |
      Hyperplasia, Lymphoid                |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                              X     X                     |      2     |
      Edema                                |                                                                3         |      2  3.0|
      Ulcer                                |    4     3           4  4  4  4              1     4  4                  |     14  3.6|
      Epidermis, Hyperplasia               |    3     3           4  3  3                 1     3  2                  |     12  3.1|
      Subcutaneous Tissue, Edema           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Osteopetrosis                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5|            |
                             DAY ON TEST   | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6|            |
                                           | 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7|      A     |
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Peripheral Nerve                        | +                                               +     +  +               |   4        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                2        1                                                |      3  2.0|
      Infiltration Cellular, Histiocyte    | 4  2  4              2     4                          4  1  4           2|     16  2.9|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Thrombosis                           |                               X                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                 X                        |      1     |
      Inflammation, Chronic                |       2        1  2                             3                        |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X  X        X              X        X  X  X        X  X        X   |     23     |
      Hydronephrosis                       |       2           3        3  3     3     2  3              4  3  2  4   |     20  3.0|
      Infiltration Cellular, Mixed Cell    |    2     2                                   2           3  2            |     11  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5|            |
                             DAY ON TEST   | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6|            |
                                           | 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7|      A     |
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3|      L     |
    MG/KG/DY                               | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic                |                               2                                          |      2  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy                          | 1  1  2     1  1  3  1        2  1  1  2  3  3  1        2  3  2  2  2  1|     40  1.8|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                             +        +   |   3        |
      Dilatation                           |                                                                      3   |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                                                      +  +|   4        |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
      Bulbourethral Gland, Cyst            |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|             
                                           | 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Edema                                |          3                                2                       2      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                                                         |             
      Cholangiofibrosis                    |                         4                                                |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                X                                                  X      |             
      Hematopoietic Cell Proliferation     | 2     4           4     3  2           3           3                 2   |             
      Hemorrhage                           |                                        3                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                       2        2         |             
      Necrosis, Focal                      |          4     4        4  2                       3                 2   |             
      Regeneration                         |                                                                          |             
      Tension Lipidosis                    |                      X                                                   |             
      Centrilobular, Necrosis              |                                        2                                 |             
      Hepatocyte, Hypertrophy              |    3           2  3                          2              2            |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  3                                       |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4                                                         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|             
                                           | 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Edema                                |          2                                                               |             
      Acinus, Cytoplasmic Alteration       |                                              3                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             2                                                     2      |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                                                  2            |             
      Erosion                              |                                                                          |             
      Glands, Hyperplasia, Cystic          |                               2                    3        2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        2        1     2              1     1  1  2  2  1  2  3         |             
      Inflammation, Chronic                |                                                       3              2   |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                       X     X  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   3              3                          3  3         |             
      Hyperplasia, Focal                   |    2        2  2                                                         |             
      Hypertrophy, Focal                   |                                                                2  3      |             
      Capsule, Hyperplasia                 |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        2  3     2     2                                   3  3         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|             
                                           | 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  3  2  2     2  3  2  2     3  2  2     4  3  3     2     1  3  3  2  2|             
      Follicular Cell, Hyperplasia         |                                                                      1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                             +            |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Spermatocele                         |                                              2              3            |             
                                           |__________________________________________________________________________|             
   Penis                                   |                                              +                           |             
      Inflammation, Chronic Active         |                                              2                           |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                X           X      |             
      Inflammation, Chronic                | 4        4  3                 3              2     2  2              4  4|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2        2              2              1           1        2|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|             
                                           | 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     4  2  2  3  4     4  4  2  4  2  2     4     4        3  2  3  4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +     +  +        +                 +        +              +   |             
      Hematopoietic Cell Proliferation     |                            3                                             |             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Iliac, Hyperplasia, Lymphoid         |                                                                      4   |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                   3                                                      |             
      Inguinal, Hyperplasia, Lymphoid      |          2        3        4                 4                           |             
      Inguinal, Pigmentation               |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |          3                                            4                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                   3      |             
      Hematopoietic Cell Proliferation     |                   3           2              2                           |             
      Hemorrhage                           |                                                    1                     |             
      Hyperplasia, Lymphoid                |       3           3        3                 3                    2      |             
      Hyperplasia, Plasma Cell             | 2                                                                        |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           3                              |             
      Ectasia                              |                            3                          2                  |             
      Hematopoietic Cell Proliferation     | 3                 3              2  3  2                                 |             
      Hemorrhage                           | 4  3     3           2  1        3  3  2     1  2  1              3      |             
      Hyperplasia, Lymphoid                |       2              2  3        3     2              2           2      |             
      Necrosis                             |       2                                                  3               |             
      Pigmentation                         |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  2  4  2  2  3  4     4  4           4        2  4     2  2  2     4  1|             
      Pigmentation                         |                                                                          |             
      Lymphoid Follicle, Atrophy           |             2        3                    2  3                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|             
                                           | 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3        2     3        2  3     3     2        3        3   |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |          3                                            3        2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          4  3                                      2        2  2         |             
      Ulcer                                | 4     4           4        4                                      3  4   |             
      Epidermis, Hyperplasia               | 3     4           4        3                                      3      |             
      Epidermis, Inflammation              |                   4                                                      |             
      Epidermis, Ulcer                     |                   4                                                      |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |          +                                   +  +     +                  |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                4         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|             
                                           | 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Foreign Body                         |                                           X                              |             
      Hemorrhage                           |                                  3     3              3     2  3         |             
      Infiltration Cellular, Histiocyte    |                               3  3     2           3  4     4  4         |             
      Inflammation, Chronic                |                                           4           3  2     3         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                           X                              |             
      Inflammation, Chronic                |                                           2                 2            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X        X     X     X  X                          X  X     X  X     X   |             
      Hydronephrosis                       |             4  3     2  2           3           3     3     2  3     2   |             
      Infiltration Cellular, Mixed Cell    | 2  2     3              2        3              2  3  3              2   |             
      Inflammation, Chronic                |       3                                                                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 2  2     3  2  3     1  2     1  2  1  1  1  2  2  2  3  1  4     1  1  1|             
      Renal Tubule, Dilatation             |             3        2              2                                    |             
      Renal Tubule, Pigmentation           |                                                             3  3         |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                      +                                                   |             
      Angiectasis                          |                      4                                                   |             
      Inflammation, Chronic                |                      3                                                   |             
      Bulbourethral Gland, Cyst            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|             
                                           | 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                      2              2                                    |             
      Inflammation, Chronic                |                                     2                                    |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4|            |
                             DAY ON TEST   | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3|            |
                                           | 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                       2                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |    2     2     2                                2     3                  |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia              |    3        2                                   2                        |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  M|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                X                                                         |      2     |
      Cholangiofibrosis                    |                                                                          |      1  4.0|
      Cyst                                 |                X              X                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                2                 3                 3           1         |     12  2.7|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                     2                                    |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.0|
      Necrosis, Focal                      |                               2                                          |      7  3.0|
      Regeneration                         |                X                                                         |      1     |
      Tension Lipidosis                    |                                                                          |      1     |
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Hypertrophy              |                               2  2                    2     3            |      9  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4|            |
                             DAY ON TEST   | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3|            |
                                           | 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Vacuolization Cytoplasmic|                                                             3            |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Edema                                |                2                                                         |      2  2.0|
      Acinus, Cytoplasmic Alteration       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |                                                       3                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      2  2.0|
      Erosion                              |                                                          3               |      1  3.0|
      Glands, Hyperplasia, Cystic          |    4  2     2              3  2     3                 2                  |     10  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                +                                                         |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  2  2     1                             2     1  2                  |     19  1.6|
      Inflammation, Chronic                |             2                                                            |      3  2.3|
      Mineralization                       |                                                                         1|      1  1.0|
      Thrombosis                           |                X                                      X                  |      5     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       3                             3        3                           |      7  3.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4|            |
                             DAY ON TEST   | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3|            |
                                           | 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy, Focal                   |       2                             2                                    |      4  2.3|
      Capsule, Hyperplasia                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       3        2                                      2  1              1|     12  2.2|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |       X                                         X                        |      3     |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |    3  2     3           2  2  3                 1     2  3  2     2  1  3|     33  2.3|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                +                                                         |   2        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |          2                                   2     3                     |      3  2.3|
      Inflammation, Chronic                |          3                                                               |      1  3.0|
      Spermatocele                         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4|            |
                             DAY ON TEST   | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3|            |
                                           | 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                     X        X     X                     |      6     |
      Inflammation, Chronic                |    2     3           4  2  2                 3     4        4        4   |     18  3.1|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3                                         2     3        2        2     3|     12  2.1|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         | 3     2  2                                         2                     |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  3  3  2     3     4  4     4  4  2           2  4     2  2  4     4   |     35  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                 +        +              +  +        +  +     +|  15        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                3         |      2  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Iliac, Pigmentation                  |          3                                                               |      1  3.0|
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                            4                       4                     |      6  3.5|
      Inguinal, Pigmentation               |          2                                                               |      1  2.0|
      Lumbar, Pigmentation                 |                                                       2                  |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                     3                                    |      3  3.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |          2                                                               |      1  2.0|
      Ectasia                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                2                 2                             4         |      6  2.5|
      Hemorrhage                           |                   2                                            2         |      3  1.7|
      Hyperplasia, Lymphoid                | 2  2  3                    3                                             |      9  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4|            |
                             DAY ON TEST   | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3|            |
                                           | 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Plasma Cell             |                2              3  4                 3           3         |      6  2.8|
      Pigmentation                         |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |          3                                                               |      2  3.0|
      Ectasia                              |                                  2                                       |      3  2.3|
      Hematopoietic Cell Proliferation     |                               2  3                             3         |      8  2.6|
      Hemorrhage                           |             3  4     3                       2  3                        |     17  2.5|
      Hyperplasia, Lymphoid                |       2                             2                                    |      9  2.2|
      Necrosis                             | 3                                                                        |      3  2.7|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    1     2     3              3  4                 4     3  3  4     3   |     27  3.0|
      Pigmentation                         |       2  2                          2                    2               |      4  2.0|
      Lymphoid Follicle, Atrophy           |                                           3                              |      5  2.6|
      Lymphoid Follicle, Hyperplasia       | 3  3  2        2                    2                                    |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                         2                    3     3  3  3           3   |     15  2.7|
      Cyst                                 |                                     X                             X      |      2     |
      Hyperplasia, Lymphoid                | 3                                   3     2                              |      6  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                2                                   2                     |      7  2.4|
      Ulcer                                |                3     4  3     4  4                 4           4         |     13  3.8|
      Epidermis, Hyperplasia               |                4     3  3     4  4                 2           4         |     12  3.4|
      Epidermis, Inflammation              |                                                                          |      1  4.0|
      Epidermis, Ulcer                     |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4|            |
                             DAY ON TEST   | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3|            |
                                           | 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                                +                             +|   7        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                2                                                         |      2  3.0|
      Fibrosis, Focal                      |                                                       3                  |      1  3.0|
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           |          2                                                     1         |      7  2.4|
      Infiltration Cellular, Histiocyte    | 2     2     2           2     1                       4                  |     13  2.8|
      Inflammation, Chronic                |                3                                                         |      5  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Chronic                |       2     1              2                                             |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4|            |
                             DAY ON TEST   | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3|            |
                                           | 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7|      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2|      L     |
    MG/KG/DY                               | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X  X  X     X  X           X  X  X  X     X  X  X  X  X           X     X|     26     |
      Hydronephrosis                       |                                           3  4  4        2  3        2  3|     17  2.8|
      Infiltration Cellular, Mixed Cell    | 2  2  3                             2     2  2  3     2                  |     17  2.4|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                              1                           |      1  1.0|
      Nephropathy                          | 1  2  3  4  1  1     1  1  2  2  2  2     1  4  2  1  4  2  2  1  1      |     42  1.9|
      Renal Tubule, Dilatation             |                                                          3           2   |      5  2.4|
      Renal Tubule, Pigmentation           |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                 +                        |   1        |
      Dilatation                           |                                                 2                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urethra                                 |             +                             +                    +     +   |   5        |
      Angiectasis                          |                                           4                          4   |      3  4.0|
      Inflammation, Chronic                |                                           3                          3   |      3  3.0|
      Bulbourethral Gland, Cyst            |             X                                                  X         |      2     |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                         3|      1  3.0|
      Hemorrhage                           |                                           3                              |      3  2.3|
      Inflammation, Chronic                |                                                 3                        |      2  2.5|
      Transitional Epithelium, Hyperplasia |                                                 2        2              2|      3  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|             
                             DAY ON TEST   | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|             
                                           | 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    200                                    | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            2                                             |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Edema                                | 2        2                 2              3  2  2     2  2  2        2   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Epithelium, Hyperplasia              | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                            X                                             |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |       X                                                                  |             
      Hematopoietic Cell Proliferation     |                                  2  2                                    |             
      Infiltration Cellular, Mixed Cell    |                                              2                 3        3|             
      Necrosis, Focal                      |                      4        4           1                              |             
      Hepatocyte, Hypertrophy              | 2        2           3     3                                      3      |             
      Kupffer Cell, Hyperplasia            |                                                                   3      |             
      Kupffer Cell, Pigmentation           |       2                       2                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Fat, Necrosis                        |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3                                         3                              |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|             
                             DAY ON TEST   | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|             
                                           | 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    200                                    | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
      Infiltration Cellular, Mixed Cell    |       2                                                        1         |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                    X                     |             
      Edema                                |          2                                                               |             
      Epithelium, Hyperplasia              |                         2                                                |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2                                                                  |             
      Glands, Hyperplasia, Cystic          |                      2  3           2        2     3  3     4  2  2     2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2        1     1  2                    2              1  2     2      |             
      Inflammation, Chronic                |       3                                                                  |             
      Mineralization                       |                               2                                          |             
      Thrombosis                           |       X              X                                            X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   3           3                 3                        |             
      Hyperplasia, Focal                   |                            1                 3                           |             
      Hypertrophy, Focal                   |                                                 2                        |             
      Capsule, Hyperplasia                 |                                              3              2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2                 2                       2     3               |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|             
                             DAY ON TEST   | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|             
                                           | 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    200                                    | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Distalis, Cyst                  |                                                                         X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1  3  3  2        2                 2        2  3     2     1           2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |    +                                                                     |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 2        2                                                               |             
                                           |__________________________________________________________________________|             
   Penis                                   |                                           +              +               |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X  X                                                     X            |             
      Inflammation, Chronic                | 3  2     4        2                                   2     2            |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       3  3  3              2                                             |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                   3      |             
      Inflammation, Chronic                |       2                                                           3      |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |          2                                1                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     3  3     2  4        3  3  4  4  4  2              2  2  2  3  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                  +  +        +                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|             
                             DAY ON TEST   | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|             
                                           | 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    200                                    | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia, Lymphoid                |                                  4  4                                    |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2     3           3                              |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hyperplasia, Lymphoid                |                   2              2  2  3                       2         |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                         2     3           3                              |             
      Ectasia                              | 3        3           2           2  4                             2      |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hemorrhage                           | 2     3  4  2                                2                 3     2   |             
      Hyperplasia, Lymphoid                |       2     2                    2                       3  3        3   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2  4        4        2     4  3  3  1  2           3        3  3   |             
      Pigmentation                         | 3                       2                                                |             
      Lymphoid Follicle, Atrophy           | 3              3     2  3     3              3     3                     |             
      Lymphoid Follicle, Hyperplasia       |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3              3     3  3  2  4  2        3        3              3      |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|             
                             DAY ON TEST   | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|             
                                           | 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    200                                    | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Edema                                | 3        4           3                    4                              |             
      Ulcer                                |                   4              4  4  4                                 |             
      Epidermis, Hyperplasia               |             2     3              3  3  4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                           2                              |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                 +         |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |       +  +                          +        +     +                     |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Edema                                |          2  3              2                 3                           |             
      Foreign Body                         |                      X                                                   |             
      Hemorrhage                           | 1     3  2                                                               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2        3           3     4                 4  4  4     4  2  2  3     3|             
      Inflammation, Chronic                |                                                          3               |             
      Alveolar Epithelium, Hyperplasia     |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic                |          2                                                        2      |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|             
                             DAY ON TEST   | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|             
                                           | 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    200                                    | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X  X  X  X     X  X     X                    X  X        X  X  X  X  X|             
      Hydronephrosis                       | 3  3     2  3        4              2     2     4     2     4     4      |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 3  3  3              3                    2     2           4            |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                    3                     |             
      Nephropathy                          | 4  2  3  2        2  4  2  2        1     4  2  2  2  1     3  1  3  3  1|             
      Renal Tubule, Dilatation             |                                                    2                     |             
      Renal Tubule, Necrosis               |       4                                                                  |             
      Renal Tubule, Pigmentation           |       2                                            2                     |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                 +                        |             
      Dilatation                           |                                                 1                        |             
                                           |__________________________________________________________________________|             
   Urethra                                 | +                                                                        |             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Bulbourethral Gland, Cyst            | X                                                                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             3                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                         2                                                |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5|                                      |            |
                             DAY ON TEST   | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9|                                      |            |
                                           | 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    200                                    | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      L     |
    MG/KG/DY                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +                                       |  33        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Edema                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +                                       |  35        |
      Edema                                |       2     2           2     2                                          |     14  2.1|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +                                       |  36        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +                                       |  36        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +                                       |  35        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Basophilic Focus                     |                                  X                                       |      2     |
      Cyst                                 |                      X                                                   |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |    4  4           3              4                                       |      6  3.2|
      Infiltration Cellular, Mixed Cell    |             3           2                                                |      5  2.6|
      Necrosis, Focal                      |             1                                                            |      4  2.5|
      Hepatocyte, Hypertrophy              |                                  2                                       |      6  2.5|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                         +        +                                       |   3        |
      Fat, Necrosis                        |                         3        3                                       |      3  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5|                                      |            |
                             DAY ON TEST   | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9|                                      |            |
                                           | 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    200                                    | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      L     |
    MG/KG/DY                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Edema                                |                                                                          |      2  3.0|
      Acinus, Cytoplasmic Alteration       |                                  4                                       |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Atrophy                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Diverticulum                         |                                                                          |      1     |
      Edema                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Edema                                |                         2                                                |      2  2.0|
      Glands, Hyperplasia, Cystic          |       2     4        2  2     3                                          |     15  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Cardiomyopathy                       |    1  1  3     2              2                                          |     13  1.7|
      Inflammation, Chronic                | 2                                                                        |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Accessory Adrenal Cortical Nodule    | 3  3                             3                                       |      6  3.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hypertrophy, Focal                   |          2  3           2                                                |      4  2.3|
      Capsule, Hyperplasia                 |                               2                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5|                                      |            |
                             DAY ON TEST   | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9|                                      |            |
                                           | 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    200                                    | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      L     |
    MG/KG/DY                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +                                       |  36        |
      Hyperplasia                          |                               1                                          |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +                                       |  35        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +                                       |  36        |
      Pars Distalis, Cyst                  | X                                                                        |      2     |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Degeneration, Cystic                 | 3        2  1  2                                                         |     15  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Atypia Cellular                      |                               2                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                  +                                       |   3        |
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Cyst                                 |                X        X                                                |      6     |
      Inflammation, Chronic                |                3     3                                                   |      8  2.6|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Inflammation, Chronic                |       4                    2                                             |      6  2.8|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5|                                      |            |
                             DAY ON TEST   | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9|                                      |            |
                                           | 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    200                                    | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      L     |
    MG/KG/DY                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation, Chronic                |       4                                                                  |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Germinal Epithelium, Atrophy         |                               2                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Hyperplasia                          | 3  4  4  4     2  3  2  3  3     4                                       |     27  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +                 +                                                |   6        |
      Hyperplasia, Lymphoid                |                                                                          |      2  4.0|
      Iliac, Hyperplasia, Lymphoid         |       4                                                                  |      1  4.0|
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |    3                                                                     |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |    3                                                                     |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |       4                                                                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Atrophy                              |                                                                          |      3  2.7|
      Ectasia                              |          4                                                               |      1  4.0|
      Hematopoietic Cell Proliferation     |    3     2        3                                                      |      4  2.5|
      Hyperplasia, Lymphoid                |          4                                                               |      6  2.5|
      Hyperplasia, Plasma Cell             |    3     2        2                                                      |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +                                       |  36        |
      Atrophy                              |                                                                          |      3  2.7|
      Ectasia                              |                                                                          |      6  2.7|
      Hematopoietic Cell Proliferation     |    3  2                                                                  |      3  2.3|
      Hemorrhage                           |                               1                                          |      8  2.4|
      Hyperplasia, Lymphoid                | 2  3     4                    2                                          |     10  2.6|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5|                                      |            |
                             DAY ON TEST   | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9|                                      |            |
                                           | 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    200                                    | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      L     |
    MG/KG/DY                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hematopoietic Cell Proliferation     |    4  4  3        4     3        4                                       |     18  3.1|
      Pigmentation                         |                                                                          |      2  2.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      7  2.9|
      Lymphoid Follicle, Hyperplasia       |          3                                                               |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  M  +  +  +  +  +  +                                       |  33        |
      Atrophy                              |       2              3           3                                       |     13  2.8|
      Cyst                                 |                               X                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Cyst Epithelial Inclusion            |                         X                                                |      1     |
      Edema                                |       3  2                       2                                       |      7  3.0|
      Ulcer                                |    4     4        4                                                      |      7  4.0|
      Epidermis, Hyperplasia               |    4     4        3                                                      |      8  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   3        |
      Pigmentation                         |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |          +           +                                                   |   7        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5|                                      |            |
                             DAY ON TEST   | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9|                                      |            |
                                           | 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    200                                    | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      L     |
    MG/KG/DY                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      4  2.5|
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           | 1                       1                                                |      5  1.6|
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
      Infiltration Cellular, Histiocyte    | 3        3           4     3                                             |     16  3.2|
      Inflammation, Chronic                |    2                                                                     |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +                                       |  36        |
      Inflammation, Chronic                |                               1                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Cyst                                 |       X  X  X     X  X  X  X  X  X                                       |     24     |
      Hydronephrosis                       | 4     2                 2  3  3                                          |     16  2.9|
      Infarct                              | 4                                                                        |      1  4.0|
      Infiltration Cellular, Mixed Cell    |          2                    2                                          |      9  2.7|
      Inflammation, Chronic                |    2              2                                                      |      2  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy                          | 1     2  1  2  1  1  1  3  1  3  2                                       |     30  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5|                                      |            |
                             DAY ON TEST   | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9|                                      |            |
                                           | 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                      |      A     |
    200                                    | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      L     |
    MG/KG/DY                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Renal Tubule, Dilatation             |                            3                                             |      2  2.5|
      Renal Tubule, Necrosis               |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urethra                                 |       +                    +                                             |   3        |
      Angiectasis                          |                            4                                             |      1  4.0|
      Inflammation, Chronic                |       3                                                                  |      1  3.0|
      Bulbourethral Gland, Cyst            |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +                                       |  37        |
      Hemorrhage                           |                            4                                             |      2  3.5|
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|             
                             DAY ON TEST   | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|             
                                           | 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
      Edema                                |             2                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                            2                                             |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A|             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                 2                        |             
      Angiectasis                          |                                                                   2      |             
      Eosinophilic Focus                   |       X                                                                  |             
      Hematopoietic Cell Proliferation     |                      2        2                                2         |             
      Hemorrhage                           |                                                                   3      |             
      Infarct                              |                                                 2                        |             
      Infiltration Cellular, Mixed Cell    |                                                             2            |             
      Necrosis, Focal                      |    4  1           1                                                      |             
      Regeneration                         |                                                 X                        |             
      Tension Lipidosis                    |                                                                      X   |             
      Hepatocyte, Hypertrophy              | 3              2  3     2     2  2  2  2     2  2        2  3     2      |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                   2      |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                                 3                        |             
      Kupffer Cell, Hyperplasia            |                                                 3                        |             
      Kupffer Cell, Pigmentation           |                   2                             3                        |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|             
                             DAY ON TEST   | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|             
                                           | 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Mesentery                               |                                                             +            |             
      Hemorrhage                           |                                                             3            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Infiltration Cellular, Lymphoid      |          1  2              2                                2            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Glands, Hyperplasia, Cystic          |                                  2              3  2           2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  2                    2        1              2  1     2         |             
      Inflammation, Chronic                |                                                                          |             
      Thrombosis                           |                                                 X     X        X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         3           3                 3  3               |             
      Hypertrophy, Focal                   | 2                                2                                       |             
      Capsule, Hyperplasia                 |                               2                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1     3                          3  2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|             
                             DAY ON TEST   | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|             
                                           | 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  I  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       3        2        2  3  3        2        3  2  1  2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 2                                                     3  2               |             
      Spermatocele                         |                                                             3            |             
                                           |__________________________________________________________________________|             
   Penis                                   |                            +                                             |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Inflammation, Chronic                |                4        2  2        2           2  3  2           4      |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3                                      4        2  3                  |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                     3                                    |             
      Dilatation                           |                                  4                 2                     |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 3        2                                               2  3            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|             
                             DAY ON TEST   | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|             
                                           | 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  4  2  2  4     4  2  3  4     2  4     4  2  2  2  2  3  3  3      |             
      Myelofibrosis                        |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +              +                                          |             
      Hyperplasia, Plasma Cell             |                4              3                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        4     3                           |             
      Hematopoietic Cell Proliferation     |                               2        2        2                        |             
      Hyperplasia, Lymphoid                | 2     2                    2  3        4     4                    2      |             
      Hyperplasia, Plasma Cell             |                3     2                 3     2                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |    2                          3              2                           |             
      Hemorrhage                           |                   1           1     4           4  3  2        2         |             
      Hyperplasia, Lymphoid                |    2           2  2           2        3                                 |             
      Pigmentation                         |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  2  2     3     4  1     4  2     3  3  4  3  1  3     2  4        3|             
      Lymphoid Follicle, Atrophy           |                                     3                                    |             
      Lymphoid Follicle, Hyperplasia       |                                                             2            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3     2     2     3        3               |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2        3     2  1        2                          3                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                4     4        4        4     4                           |             
      Epidermis, Hyperplasia               |                4     4                 4     3                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|             
                             DAY ON TEST   | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|             
                                           | 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Fracture                             |                                                                          |             
      Femur, Osteopetrosis                 |                                  2                 4                     |             
      Scapula, Osteopetrosis               |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                            +        +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |             +              +                                             |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X                                                                  |             
      Demyelination                        |                            3                                             |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  |                                                          +               |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                      X   |             
      Hemorrhage                           |                2                                                  3      |             
      Hyperplasia, Lymphoid                |                                                          3               |             
      Infiltration Cellular, Histiocyte    |       4  2  2           1     4  2  4     3     4  3  4  4     3         |             
      Inflammation, Chronic                |       3                                                                  |             
      Alveolar Epithelium, Hyperplasia     |                         3                          3           1         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2              1         |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|             
                             DAY ON TEST   | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|             
                                           | 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    MG/KG/DY                               | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                    X  X  X  X  X  X        X  X  X  X  X  X         |             
      Hydronephrosis                       | 2        3  2  2                       2           2  2     2  3        2|             
      Infarct                              |                            2                                             |             
      Infiltration Cellular, Mixed Cell    |          2  2                          2     2  2  2  3     2  2         |             
      Nephropathy                          | 2  1  1     1     1     2  1  1  2  2           3  3  4  1  2  3  2      |             
      Renal Tubule, Dilatation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                  +                 +           +         |             
      Angiectasis                          |                                                    4                     |             
      Bulbourethral Gland, Cyst            |                                  X                             X         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    3                                      3                              |             
      Hemorrhage                           |                                                    2                     |             
      Inflammation, Chronic                |                                           3                              |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 4| 5| 2| 4|                                                     |            |
                             DAY ON TEST   | 6| 6| 2| 0| 3| 2| 8|                                                     |            |
                                           | 9| 8| 7| 4| 9| 9| 8|                                                     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0|                                                     |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0|                                                     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4|                                                     |      A     |
    300                                    | 1| 1| 2| 2| 2| 2| 2|                                                     |      L     |
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4|                                                     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +                                                      |  32        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  A  +  +                                                      |  27        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +                                                      |  32        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +                                                      |  31        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +                                                      |  30        |
      Edema                                |    2                                                                     |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +                                                      |  32        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +                                                      |  29        |
      Epithelium, Hyperplasia              |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +                                                      |  30        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +                                                      |  32        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Eosinophilic Focus                   |       X                                                                  |      2     |
      Hematopoietic Cell Proliferation     |          4        2                                                      |      5  2.4|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                   2                                                      |      2  2.0|
      Necrosis, Focal                      |                                                                          |      3  2.0|
      Regeneration                         |                                                                          |      1     |
      Tension Lipidosis                    |                                                                          |      1     |
      Hepatocyte, Hypertrophy              |    2              3                                                      |     15  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 4| 5| 2| 4|                                                     |            |
                             DAY ON TEST   | 6| 6| 2| 0| 3| 2| 8|                                                     |            |
                                           | 9| 8| 7| 4| 9| 9| 8|                                                     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0|                                                     |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0|                                                     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4|                                                     |      A     |
    300                                    | 1| 1| 2| 2| 2| 2| 2|                                                     |      L     |
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4|                                                     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  3.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           |                   2                                                      |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +                                                      |  31        |
      Cyst                                 |                                                                          |      1     |
      Infiltration Cellular, Mixed Cell    |    2                                                                     |      1  2.0|
      Acinus, Cytoplasmic Alteration       |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +                                                      |  32        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphoid      |    2                                                                     |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +                                                      |  32        |
      Epithelium, Hyperplasia              | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +                                                      |  32        |
      Erosion                              |             2                                                            |      1  2.0|
      Glands, Hyperplasia, Cystic          | 2           3                                                            |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +                                                      |  32        |
      Cardiomyopathy                       |                                                                          |      7  1.7|
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
      Thrombosis                           |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +                                                      |  32        |
      Accessory Adrenal Cortical Nodule    | 3     3                                                                  |      6  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 4| 5| 2| 4|                                                     |            |
                             DAY ON TEST   | 6| 6| 2| 0| 3| 2| 8|                                                     |            |
                                           | 9| 8| 7| 4| 9| 9| 8|                                                     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0|                                                     |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0|                                                     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4|                                                     |      A     |
    300                                    | 1| 1| 2| 2| 2| 2| 2|                                                     |      L     |
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4|                                                     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy, Focal                   | 2  2                                                                     |      4  2.0|
      Capsule, Hyperplasia                 |          2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +                                                      |  32        |
      Hyperplasia                          |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +                                                      |  31        |
      Hyperplasia                          |    2              1                                                      |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +                                                      |  28        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +                                                      |  31        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +                                                      |  32        |
      Degeneration, Cystic                 | 2  2  1  2  3                                                            |     15  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                +                                                         |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +                                                      |  32        |
      Atypia Cellular                      |                                                                          |      3  2.3|
      Spermatocele                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +                                                      |  32        |
      Cyst                                 |       X                                                                  |      2     |
      Inflammation, Chronic                |       2                                                                  |      9  2.6|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 4| 5| 2| 4|                                                     |            |
                             DAY ON TEST   | 6| 6| 2| 0| 3| 2| 8|                                                     |            |
                                           | 9| 8| 7| 4| 9| 9| 8|                                                     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0|                                                     |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0|                                                     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4|                                                     |      A     |
    300                                    | 1| 1| 2| 2| 2| 2| 2|                                                     |      L     |
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4|                                                     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Prostate                                | +  +  +  +  +  +  +                                                      |  32        |
      Inflammation, Chronic                |       2                                                                  |      5  2.8|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +                                                      |  32        |
      Degeneration                         |                                                                          |      1  3.0|
      Dilatation                           |       3                                                                  |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +                                                      |  32        |
      Germinal Epithelium, Atrophy         |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +                                                      |  32        |
      Hyperplasia                          | 3  2  3  3        3                                                      |     24  2.9|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +                                                      |  32        |
      Ectasia                              |                                                                          |      2  3.5|
      Hematopoietic Cell Proliferation     |    2     3                                                               |      5  2.2|
      Hyperplasia, Lymphoid                |    3              3                                                      |      9  2.8|
      Hyperplasia, Plasma Cell             |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +                                                      |  32        |
      Ectasia                              |       2           3                                                      |      2  2.5|
      Hematopoietic Cell Proliferation     |          2                                                               |      4  2.3|
      Hemorrhage                           | 1           1                                                            |      9  2.1|
      Hyperplasia, Lymphoid                |          4                                                               |      6  2.5|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +                                                      |  32        |
      Hematopoietic Cell Proliferation     | 1  1     4                                                               |     20  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 4| 5| 2| 4|                                                     |            |
                             DAY ON TEST   | 6| 6| 2| 0| 3| 2| 8|                                                     |            |
                                           | 9| 8| 7| 4| 9| 9| 8|                                                     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0|                                                     |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0|                                                     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4|                                                     |      A     |
    300                                    | 1| 1| 2| 2| 2| 2| 2|                                                     |      L     |
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4|                                                     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Lymphoid Follicle, Atrophy           |             3                                                            |      2  3.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +                                                      |  32        |
      Atrophy                              |       3  2                                                               |      7  2.6|
      Cyst                                 | X                                                                        |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +                                                      |  32        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +                                                      |  32        |
      Edema                                |          2                                                               |      1  2.0|
      Ulcer                                |    4                                                                     |      6  4.0|
      Epidermis, Hyperplasia               |    3                                                                     |      5  3.6|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +                                                      |  32        |
      Fibrous Osteodystrophy               |       2                                                                  |      1  2.0|
      Fracture                             |                X                                                         |      1     |
      Femur, Osteopetrosis                 |                                                                          |      2  3.0|
      Scapula, Osteopetrosis               |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +                                                      |  32        |
      Necrosis                             | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                   +                                                      |   3        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 4| 5| 2| 4|                                                     |            |
                             DAY ON TEST   | 6| 6| 2| 0| 3| 2| 8|                                                     |            |
                                           | 9| 8| 7| 4| 9| 9| 8|                                                     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0|                                                     |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0|                                                     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4|                                                     |      A     |
    300                                    | 1| 1| 2| 2| 2| 2| 2|                                                     |      L     |
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4|                                                     |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Spinal Cord                             | +  +  +  +  +  +  +                                                      |  32        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Demyelination                        |                                                                          |      1  3.0|
      Necrosis                             |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +                                                      |  32        |
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |             2                                                            |     14  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                   4                                                      |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +                                                      |  32        |
      Inflammation, Chronic                |    2  2                                                                  |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +                                                      |  32        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +                                                      |  32        |
      Hyperplasia, Focal                   |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +                                                      |  32        |
      Cyst                                 |       X     X  X  X                                                      |     17     |
      Hydronephrosis                       |       3     2  2  3                                                      |     14  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 133                                                               
                                                                                                                                   
NTP Experiment-Test: 99022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:42    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 4| 5| 2| 4|                                                     |            |
                             DAY ON TEST   | 6| 6| 2| 0| 3| 2| 8|                                                     |            |
                                           | 9| 8| 7| 4| 9| 9| 8|                                                     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0|                                                     |      O     |
   SWISS MICE MALE                         | 0| 0| 0| 0| 0| 0| 0|                                                     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4|                                                     |      A     |
    300                                    | 1| 1| 2| 2| 2| 2| 2|                                                     |      L     |
    MG/KG/DY                               | 8| 9| 0| 1| 2| 3| 4|                                                     |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |       3  3        2                                                      |     12  2.3|
      Nephropathy                          | 1  2  4  1  1     4                                                      |     23  2.0|
      Renal Tubule, Dilatation             |             2                                                            |      1  2.0|