National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20259

TDMS Study 99022-02 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                       DATE: 10/08/03       
EXPERIMENT: 99022 TEST: 02                                                                                     TIME: 16:02:48       
TEST TYPE:  PERINATAL EXPOS                     CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15328                              ROUTE: IN-UTERO                                                NTP C#: C99022       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 30516-87-1      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             FINAL/MICE                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       MERGE   001   001,011                    0       MG/KG/DY                                    
                                       MERGE   002   002,012                    50      MG/KG/DY                                    
                                       MERGE   003   003,013                    100     MG/KG/DY                                    
                                       MERGE   004   004,014                    200     MG/KG/DY                                    
                                       MERGE   005   005,015                    300     MG/KG/DY                                    
                                       MERGE   006   006,016                    0       MG/KG/DY                                    
                                       MERGE   007   007,017                    50      MG/KG/DY                                    
                                       MERGE   008   008,018                    100     MG/KG/DY                                    
                                       MERGE   009   009,019                    200     MG/KG/DY                                    
                                       MERGE   010   010,020                    300     MG/KG/DY                                    
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                       DATE: 10/08/03       
EXPERIMENT: 99022 TEST: 02                                                                                     TIME: 16:02:48       
TEST TYPE:  PERINATAL EXPOS                     CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-15328                              ROUTE: IN-UTERO                                                NTP C#: C99022       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 30516-87-1      
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 0       MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 19        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      104   111   308   322   329   329   373   392   413   418                 |                                                 
 |      446   453   463   475   486   488   497   532   538   560                 |                                                 
 |      565   567   601   603   614   619   621   635   641   654                 |                                                 
 |      661                                                                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 50      MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 29     CENSORED DEATHS 0    TERMINAL 21        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      45    147   157   168   229   236   254   300   322   322                 |                                                 
 |      329   363   385   418   432   444   467   475   479   495                 |                                                 
 |      523   562   567   580   588   592   595   624   640                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 100     MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 1    TERMINAL 13        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      147   187   214   229   243   308   320   322   376   376                 |                                                 
 |      413   434   474   481   482   489   490   505   510   532                 |                                                 
 |      536   538   544   546   567   570   598   605   606   607                 |                                                 
 |      608   627   631   633   648   651                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      315                                                                       |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 200     MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 36     UNCENSORED DEATHS 28     CENSORED DEATHS 1    TERMINAL 7         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      157   167   298   301   320   329   329   341   382   434                 |                                                 
 |      483   501   531   539   549   563   580   589   599   607                 |                                                 
 |      608   612   624   625   631   631   647   662                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      159                                                                       |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 300     MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 32     UNCENSORED DEATHS 22     CENSORED DEATHS 2    TERMINAL 8         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      192   229   329   329   329   376   404   473   488   495                 |                                                 
 |      538   539   563   569   593   627   634   635   638   640                 |                                                 
 |      655   661                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      41    41                                                                  |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   668 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0          |   100.0  96.0  96.0  88.0  80.0  72.0  62.0  52.0  38.0  38.0      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |50         |    98.0  92.0  86.0  76.0  72.0  62.0  58.0  46.0  42.0  42.0      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |100        |   100.0  98.0  90.0  83.9  77.8  69.6  53.2  43.0  26.6  26.6      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |200        |   100.0  94.4  94.4  77.2  74.3  68.6  60.0  45.8  20.0  20.0      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |300        |   100.0 100.0  93.3  83.3  76.7  73.3  60.0  50.0  26.7  26.7      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
 ===============================================================================================================================    
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    
 |                                                                                                                             |    
 |                                                                                                                             |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |                                                                           DOSE                                              |    
 |                                                                                                                             |    
 |                                0                  50                 100                200                300              |    
 |                                MG/KG/DY           MG/KG/DY           MG/KG/DY           MG/KG/DY           MG/KG/DY         |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |SURVIVAL AT END OF STUDY|       38.0%              42.0%              26.6%              20.0%              26.7%            |    
 |(KAPLAN-MEIER)          |                                                                                                    |    
 |                        |                                                                                                    |    
 |SIGNIFICANCE (B)        |       P=0.249            P=1.000            P=0.288            P=0.161            P=0.553          |    
 |(LIFE TABLE)            |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN DAY OF             |       478.0              404.8              473.5              487.1              497.1            |    
 |NATURAL DEATHS (C)      |       (26.1)             (30.5)             (24.1)             (28.7)             (31.0)           |    
 |(STANDARD ERROR)        |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN LIFE SPAN (D)      |       550.2              515.3              520.9              513.2              511.3            |    
 |(STANDARD ERROR)        |       (20.8)             (25.6)             (21.5)             (27.2)             (33.1)           |    
 |                        |                                                                                                    |    
 ===============================================================================================================================    
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 0       MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      105   179   248   255   287   352   372   391   443   443                 |                                                 
 |      460   497   510   535   558   573   577   581   588   588                 |                                                 
 |      593   598   598   599   609   612   644   648   651   658                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 50      MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 1    TERMINAL 18        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      207   219   290   326   341   350   369   395   412   417                 |                                                 
 |      441   472   475   475   476   500   500   521   536   539                 |                                                 
 |      549   556   559   560   560   565   577   577   600   644                 |                                                 
 |      655                                                                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      402                                                                       |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 100     MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      181   182   237   322   328   332   362   425   432   460                 |                                                 
 |      490   495   514   524   537   574   585   590   612   619                 |                                                 
 |      621   631   640   650   654   666                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 200     MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 40     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 20        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      359   414   488   497   510   510   523   530   539   541                 |                                                 
 |      561   565   572   603   608   614   641   646   662   667                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 300     MG/KG/DY                               |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 42     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 19        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      43    49    207   325   332   412   453   455   467   474                 |                                                 
 |      479   482   482   530   539   565   580   585   593   593                 |                                                 
 |      598   641   645                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   668 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0          |   100.0  96.0  92.0  88.0  84.0  78.0  72.0  52.0  40.0  40.0      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |50         |   100.0 100.0  96.0  88.0  79.9  69.7  59.4  41.0  36.9  36.9      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |100        |   100.0 100.0  94.0  86.0  84.0  80.0  70.0  64.0  50.0  48.0      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |200        |   100.0 100.0 100.0  97.5  95.0  95.0  75.0  65.0  52.5  50.0      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 |300        |    95.2  95.2  92.9  88.1  85.7  69.0  64.3  50.0  45.2  45.2      |                                                 
 |MG/KG/DY   |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 668 DAYS                                                                         
 ===============================================================================================================================    
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    
 |                                                                                                                             |    
 |                                                                                                                             |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |                                                                           DOSE                                              |    
 |                                                                                                                             |    
 |                                0                  50                 100                200                300              |    
 |                                MG/KG/DY           MG/KG/DY           MG/KG/DY           MG/KG/DY           MG/KG/DY         |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |SURVIVAL AT END OF STUDY|       40.0%              36.9%              48.0%              50.0%              45.2%            |    
 |(KAPLAN-MEIER)          |                                                                                                    |    
 |                        |                                                                                                    |    
 |SIGNIFICANCE (B)        |       P=0.398N           P=0.549            P=0.521N           P=0.336N           P=0.942N         |    
 |(LIFE TABLE)            |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN DAY OF             |       491.7              473.0              487.0              552.5              457.8            |    
 |NATURAL DEATHS (C)      |       (27.8)             (20.8)             (29.4)             (17.8)             (35.0)           |    
 |(STANDARD ERROR)        |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN LIFE SPAN (D)      |       562.2              541.8              573.9              610.3              552.9            |    
 |(STANDARD ERROR)        |       (20.7)             (18.7)             (19.9)             (12.8)             (25.0)           |    
 |                        |                                                                                                    |    
 ===============================================================================================================================    
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                              AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                               
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0       MG/KG/DY = 1                                                        
                                                        50      MG/KG/DY = 2                                                        
                                                        100     MG/KG/DY = 3                                                        
                                                        200     MG/KG/DY = 4                                                        
                                                        300     MG/KG/DY = 5                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 +  1       2         1      3  4     5                                                                                        
      |          2         11     2  44  3 5     5                                                                                  
      |                     1     2  22  3    3  3           41 1                                                                   
      |                               2          2 3            11                                                                  
   90 +                                          223          3                                                                     
      |                                           2  2       43 31        1                                                         
      |                                              2       2  24        1 1   1                                                   
      |                                                          5        5     11                                                  
P  80 +                                                         22  4     3    531    1                                             
E     |                                                          2  4  2   4   53  3  11   5                                        
R     |                                                                2   2     2 3   1 1 1                                        
C     |                                                                          2 2       131                                      
E  70 +                                                                            2  2     335                                     
N     |                                                                               2  2  4114     5                              
T     |                                                                                  2 22314 3  11                              
      |                                                                                     2 2  3  31   1                          
S  60 +                                                                                       2    233  411                         
U     |                                                                                            2    4 25                        
R     |                                                                                              3 3  1  2  11                  
V     |                                                                                                    5 224 1 1                
I  50 +                                                                                                3  33  22   115              
V     |                                                                                                    3   43    55             
A     |                                                                                                        233  1211            
L     |                                                                                                                1  1 2       
   40 +                                                                                                          4 4  55  11        
      |                                                                                                          3 4 3     11       
      |                                                                                                              33             
      |                                                                                                              445  5         
   30 +                                                                                                               3  355        
      |                                                                                                                  3 53       
      |                                                                                                               4  4          
      |                                                                                                                  4 4        
   20 +                                                                                                                    44       
      |                                                                                                                             
      ---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
         0          10          20          30          40          50          60          70          80          90          100 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 59 obs hidden.                                                                                                                
                                                                                                                                   
                                              AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                               
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0       MG/KG/DY = 1                                                        
                                                        50      MG/KG/DY = 2                                                        
                                                        100     MG/KG/DY = 3                                                        
                                                        200     MG/KG/DY = 4                                                        
                                                        300     MG/KG/DY = 5                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 +  1       5         1            3    2                         4                                                            
      |                    1            1    2 2                       4         4                                                  
      |          5                      1    5 2  3 11     2    32               4           4                                      
      |                                      5       1    1     32  2                        44                                     
   90 +                                                   1      3 3221                       4  4                                  
      |                                                            3 213 21     5                                                   
P     |                                                                3 21 12  2 33  15         4 4                                
E     |                                                                         22 3    3          44                               
R  80 +                                                                          2   21515   3      44                              
C     |                                                                              2  15 2 31      4 4                            
E     |                                                                                    55 1  133 1 4  4                         
N     |                                                                                            3 1   1                          
T  70 +                                                                                    25  2    53   141                        
      |                                                                                             55     1 13  4                  
S     |                                                                                        2   2 5    5  113   3                
U     |                                                                                            2 2    5  5   4 33               
R  60 +                                                                                              2  2    511   4   4            
V     |                                                                                                 22    511   3 34 4          
I     |                                                                                                               33 3 4        
V     |                                                                                                        511       3344       
A  50 +                                                                                                  22     51 1   5  3 3       
L     |                                                                                                   2  2     1   1 5  3       
      |                                                                                                                1 1  5       
      |                                                                                                      2  2        11         
   40 +                                                                                                         2      2  1 1       
      |                                                                                                                   2 2       
      |                                                                                                                             
      |                                                                                                                             
   30 +                                                                                                                             
      |                                                                                                                             
      ---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
         0          10          20          30          40          50          60          70          80          90          100 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 41 obs hidden.                                                                                                                
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.