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TDMS Study 88138-03 Pathology Tables

NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03
Route: DOSED FEED                                                                                                 Time: 15:26:04

                                                         FINAL #1 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  04/26/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|             
                                           | 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Metaplasia, Mucous                   |                                                                          |             
      Parasite Metazoan                    |                                                                1         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | 1  1  1  1                    1     1                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1                                1                  |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X     X  X           X                    X                       X  X|             
      Degeneration, Cystic                 |                                                                          |             
      Fatty Change, Diffuse                |                                                    2     1               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Chronic Active         | 1  1  1  1  1  1  1  1  2  2  1  1  1  1  1  2  1  1  1     1  1     1  1|             
      Mixed Cell Focus                     |    X                       X                                         X  X|             
      Necrosis                             |             1                                            1        1     1|             
      Bile Duct, Hyperplasia               |       1     1                 1                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +           +                                +           +      |             
      Fat, Necrosis                        |          2           1                                1           1      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                     +                                    |             
      Gingival, Inflammation               |                                     1                                    |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|             
                                           | 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1                    1     1  3  1        1      |             
      Acinus, Atrophy                      |          1  1  1     1                 1              1     1  1     1   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         1                                                |             
      Basophilic Focus                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2  1  1  2  1  1  1  1  2  1  1  2  1  1  1  1     1  1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2  1  1  2  1  1  2  2  1  1  1  1  1  1  1  2  2  2  1  1  2  2  3  1|             
      Atrophy                              |                                  1                                       |             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                 1        1               |             
      Hypertrophy                          |       1                 1                    1  1  1                     |             
      Karyomegaly                          |                                                                      1   |             
      Necrosis                             |                                                          1        2      |             
      Vacuolization Cytoplasmic            | 1           1     2     1           1        1              1  1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                   1      |             
      Vacuolization Cytoplasmic            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|             
                                           | 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3  1  1  1     4     2        1  2  1     2  3        3     2     1  4|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1     2        1        3  1  1  4  2  2  1  2  4              1     1   |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3  4  3  2     2        1  2  4  2  1  1  1  1  3  3  1  1     1     1  1|             
      Follicle, Cyst                       |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   1      |             
      Hyperplasia                          |                                        2  4                             2|             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                         X           X            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |          1              1     2        1                    4     1     1|             
      Endometrium, Hyperplasia, Adenomatous|                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|             
                                           | 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Erythroid Cell, Hyperplasia          |                               1     1     1        1  1           2  1   |             
      Myeloid Cell, Hyperplasia            | 1                                   2     1              3        3  1   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +                          +           +  +   |             
      Deep Cervical, Ectasia               |                            1                                             |             
      Deep Cervical, Hemorrhage            |                                                                          |             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Plasma Cell                     |                                                       2              1   |             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Histiocyte                      |                            1                          2                  |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  2  1  2  3  2  1  1  1  1  2  1  2  2  2  2  1  2  1  2  2  1  1  2|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          3                                                               |             
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  2  2  2  1  1  1  1  2  1  1  1  1  1  1  1  1  1     1  1|             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          |          2                                                               |             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  4  3  4  4  4  3  3  3  3  3  3  3  4  4  4  3  3  4  3  3  4  3  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |       4           4                                            4  4      |             
      Hyperplasia                          |                                                          1               |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|             
                                           | 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                      4      |             
      Hydrocephalus                        |                            3                                             |             
      Inflammation                         |                            1                                             |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |    1  1                 2     1              1  1  1  1     1            |             
      Alveolar Epithelium, Hyperplasia     | 1                    1  2  1                 1     1     3               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2     3                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      | 1  1              1  1  1        1              1     1     1            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|             
                                           | 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             4            |             
      Inflammation, Chronic Active         |                   2                                                      |             
      Nephropathy                          | 1  1  1  1  1  1  3  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1|             
      Cortex, Mineralization               |                                              1                           |             
      Medulla, Fibrosis                    |                   2                                                      |             
      Medulla, Mineralization              | 1  1  1     1     1  1  1  1  1  1  1  1  1  1     2  1  1  1  1  1  1  1|             
      Pelvis, Inflammation                 |                                                             3            |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                             1            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3|            |
                                           | 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                2         |      1  2.0|
      Metaplasia, Mucous                   |                                                                3         |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                               1        2                                 |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.0|
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X|     48     |
      Clear Cell Focus                     | X  X  X                       X     X           X                 X     X|     15     |
      Degeneration, Cystic                 |                1                                                         |      1  1.0|
      Fatty Change, Diffuse                |    1     1              1     1  2                 1  3        2     2   |     11  1.5|
      Hematopoietic Cell Proliferation     |    1                                                                     |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X              X  X                                   X         |      5     |
      Inflammation, Chronic Active         | 2     2     2  2  2  2  2  2  2  2  1  3  2  2  2  2  1  2  2  1  2  2  2|     46  1.5|
      Mixed Cell Focus                     | X  X                          X                 X           X  X         |     10     |
      Necrosis                             | 1  1     1  1           1        2     1                          1      |     12  1.1|
      Bile Duct, Hyperplasia               |    2     2                       2  1           1           1           1|     10  1.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +  +     +  +     +        +           +              +         |  12        |
      Fat, Necrosis                        |             2     1  2     1        2           1              1         |     11  1.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3|            |
                                           | 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |             +                                +           +               |   4        |
      Gingival, Inflammation               |             1                                1           3               |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                1        1  1     1                          1     1      |     12  1.2|
      Acinus, Atrophy                      | 1        4        1        1  1  1                                1     1|     17  1.2|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                             1            |      2  1.0|
      Basophilic Focus                     |                                              1                           |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                3     1   |      2  2.0|
      Inflammation                         |                         1                          1           2     1   |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     2  1  1  1  1  2  2  1  1  1  2  1  2  1  1  2        1  1  2  1  1|     46  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1  1  1        2  1  2  1  2        1  1  1  1  2  1        1     2     1|     42  1.4|
      Atrophy                              |                                                                          |      1  1.0|
      Degeneration, Cystic                 |             1  1                                                     1   |      3  1.0|
      Hematopoietic Cell Proliferation     |    1                                      1     1                        |      3  1.0|
      Hyperplasia                          |                            1                 2  1           1            |      6  1.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3|            |
                                           | 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy                          |             1                                                           1|      7  1.0|
      Karyomegaly                          |                                                                          |      1  1.0|
      Necrosis                             |          2                             1                             1   |      5  1.4|
      Vacuolization Cytoplasmic            |          2                 1     1              1           1  3         |     14  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |          3                                                               |      2  2.0|
      Vacuolization Cytoplasmic            |                                                          1               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1  1  2              2  4  2  4  4  1        1     4        2  1     4  2|     30  2.2|
      Cyst                                 |                1                                         1               |      2  1.0|
      Hyperplasia                          | 2  4     2     1           4              4  3              4  1         |     23  2.2|
      Inflammation                         |                                                 1                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1  4     2        1  1              1     3  1  1  4        1     1  1  1|     34  1.8|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        2                                4|      3  2.3|
      Hyperplasia                          |                                     2     2     1                        |      6  2.2|
      Inflammation                         |                                              3                          3|      2  3.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3|            |
                                           | 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             X  X        X                                                |      6     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |             2              4                                   2  1     1|     12  1.8|
      Endometrium, Hyperplasia, Adenomatous|                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                 2                        |      1  2.0|
      Myelofibrosis                        |             1                       1                                    |      2  1.0|
      Erythroid Cell, Hyperplasia          |                                  1                                       |      8  1.1|
      Myeloid Cell, Hyperplasia            |          4                       1     1  1              1               |     11  1.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                         +        +                             +     +   |   8        |
      Deep Cervical, Ectasia               |                                                                          |      1  1.0|
      Deep Cervical, Hemorrhage            |                         2                                                |      1  2.0|
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Plasma Cell                     |                                                                2         |      3  1.7|
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Histiocyte                      |                         2                                                |      3  1.7|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                  2                                   1   |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    | 2  1  1  2  2  2  1  1  2  1  1  1  1  2  1  3  1  2  1  3  1  1  3  1  2|     50  1.6|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1|     47  1.1|
      Infarct                              |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3|            |
                                           | 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            | 1  1  1     1  1  1  1  2  1  1  1  1  1  1  1  1  1     1  1  2  1  1  2|     48  1.1|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  4  3     3  3  3  3  4  3  4  4  3  3  4  3  3  4  3  4  3  3  3  3  3|     49  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                      4     4                                   1         |      7  3.6|
      Hyperplasia                          |                         1        1                                       |      3  1.0|
      Inflammation                         |                                                       3                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                       +                  |   1        |
      Inflammation                         |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  3.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                     1        1     1                     |     12  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3|            |
                                           | 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     | 2  1           4           1           1     1  2  1        2  1        1|     18  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  1|     50  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                         1|      1  1.0|
      Lens, Cataract                       |                                                                         3|      1  3.0|
      Retina, Degeneration                 |          1                                                              4|      2  2.5|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphoid      |                         1  1     1              1                 1      |     14  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nephropathy                          | 1     1  1  1  1  1  1  2  1  1  2  1  1  1  1  1  2     1  1  1  1  1  1|     47  1.1|
      Cortex, Mineralization               |                                                                   1      |      2  1.0|
      Medulla, Fibrosis                    |                                                                          |      1  2.0|
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1     1     1     1  1|     43  1.0|
      Pelvis, Inflammation                 |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                        1                                 |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Periesophageal Tissue, Necrosis,     |                                                                          |             
           Fatty                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             1                 1                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    1           2     1  1                       1           1           1|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                                            |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X|             
      Clear Cell Focus                     |          X        X        X                       X                     |             
      Eosinophilic Focus                   |    X                          X                                   X      |             
      Fatty Change, Diffuse                |          1        1                    4                             4   |             
      Hematopoietic Cell Proliferation     |       1           1                          1        2     1            |             
      Hepatodiaphragmatic Nodule           |    X           X                             X  X                        |             
      Inflammation, Chronic Active         | 1  2     1  1  1  2  1  2  1        1     2  2  2  2  2  1     2  2     2|             
      Mixed Cell Focus                     |       X        X     X  X                       X        X              X|             
      Necrosis                             |                                  1     1                             3   |             
      Bile Duct, Hyperplasia               | 1     1  1  1  1        1  1  3  1  2  2  1  1  1  1     1        1  2  1|             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |    1                 1  1           2     1  1     1  1  1     1  1     1|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Mesentery                               |       +  +           +     +  +           +                 +  +        +|             
      Fat, Necrosis                        |       2  1           2     1  1           3                 1  2        2|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                   +                       +                              |             
      Gingival, Inflammation               |                   1                       1                              |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           1              1               |             
      Acinus, Atrophy                      |       1  1  1           1     1              1  1                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                      3   |             
      Inflammation                         |                                                                      1   |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  2  1  2  2  1  2  1     2  1     2  2  1  1  1  1  2  1  1  1|             
      Atrium, Thrombosis                   |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1     1  1  1  1  1  1  1        1        1  1     2  1  1  1  1     1|             
      Degeneration, Cystic                 |                                              1                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                1           1     1  1        1              2  1     1  1|             
      Hypertrophy                          |                         1                                         1  1   |             
      Necrosis                             |                               1  1                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Vacuolization Cytoplasmic            |       2  1        1     1  1        1                          1     3   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 4     3  1     4  1     3  1              2  3  1     4     1     2     1|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    3  3           4  1              1           3  2        2  2  3     3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4                 1                    1  1                              |             
      Follicle, Hyperplasia                |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                                                        |             
      Hyperplasia                          |                   2                                                      |             
      Inflammation                         | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X     X           X                             X           X         |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |       1     2  2  2  4     4  2     1     1                    1     2  1|             
      Endometrium, Hyperplasia, Adenomatous|                                                                          |             
      Serosa, Inflammation, Granulomatous  |                                                             1            |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                       2                  |             
      Erythroid Cell, Hyperplasia          | 1                                1                 1           1         |             
      Myeloid Cell, Hyperplasia            |                               3  3     2              4     2        4   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +     +  +     +              +                 +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Hemorrhage               |                         2                             2                  |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                         2                             2                 3|             
      Pancreatic, Pigmentation, Hemosiderin|                         3                             3                  |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  2  1  1  2     1  2  2  2  1  1  2  2  3  1  2  2  1  2  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1  1  1  1     1  1     1  2  1  1  1  1  1  1|             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Granulomatous          |                                                       4                  |             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |          1                                                               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              | 3  4  3  4  3  4  3  4  3  4  3  4  4  4  4  3  4  3  4     4  3  3  4  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Galactocele                          |                            4                                             |             
      Hyperplasia                          |                                                       2                  |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
      Inflammation                         |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      1   |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                           1                             1|             
      Inflammation, Granulomatous          |                      1     1                                   1         |             
      Alveolar Epithelium, Hyperplasia     | 1           2           1                 1           1     1  2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  2  2  1  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                             +            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                  1                                       |             
      Retina, Dysplasia                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      |       1           1                          1     1           1  1     1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                  X                                       |             
      Nephropathy                          | 2  1  2  1  1  1  2  1  2  1  1  1  1  1  2  2  1  1  2  2  1     1  1  1|             
      Cortex, Mineralization               |             1                                                            |             
      Medulla, Mineralization              | 1  1  1  2  1  1  2  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |             1                    2                                       |             
      Renal Tubule, Hyperplasia            | 4                                                                        |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |          2                                                               |      1  2.0|
      Periesophageal Tissue, Necrosis,     |                                                                          |            |
           Fatty                           |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   1                                                      |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                   1      |      8  1.1|
      Ulcer                                |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  1                                       |      2  1.0|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     48     |
      Clear Cell Focus                     |    X  X     X  X           X  X                 X     X                 X|     13     |
      Eosinophilic Focus                   |                      X     X              X                              |      6     |
      Fatty Change, Diffuse                |                1                    2                    3     1         |      8  2.1|
      Hematopoietic Cell Proliferation     |                            1                                             |      6  1.2|
      Hepatodiaphragmatic Nodule           | X                          X                                             |      6     |
      Inflammation, Chronic Active         | 1  1  2  2  1     2     1  2  2        1  1     1  2  2     1  1  2  1  1|     38  1.5|
      Mixed Cell Focus                     |                            X                          X           X     X|     11     |
      Necrosis                             |                                  1  1                    1               |      6  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Hyperplasia               | 1           1  1     2  1  1  1  2     1  2  1  1  1  1     1        1   |     35  1.2|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      | 1  1  1        1  1     1  1  1        1        1  1  1           1  1  1|     27  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +  +        +     +  +  +  +                 +     +               |  18        |
      Fat, Necrosis                        |       3  1        3     2  4  2  2                 2     2               |     18  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                   +        +  +     +        +           +               |   8        |
      Gingival, Inflammation               |                   1        1  1     2        1                           |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |          1                                                               |      3  1.0|
      Acinus, Atrophy                      |       1                                      1                 1         |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                     2                                    |      2  2.5|
      Inflammation                         |                                     2                                    |      2  1.5|
      Ulcer                                |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                     2                                    |      1  2.0|
      Mineralization                       |       1                                                                  |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  2  1  2  1  2  1  2  2  1  2  1  1  1     2  1  2     1  1  1  1  2|     46  1.4|
      Atrium, Thrombosis                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1  1  1     2  1  1        1  1  2     1  1     1  1  1        1  1  1  1|     36  1.1|
      Degeneration, Cystic                 |                               1                                          |      2  1.0|
      Hematopoietic Cell Proliferation     |                            1                                             |      1  1.0|
      Hyperplasia                          |                                                       1                  |     10  1.1|
      Hypertrophy                          |                               3  1                                       |      5  1.4|
      Necrosis                             |          2           1           1           3              1            |      7  1.4|
      Vacuolization Cytoplasmic            |             1                 1  1  3  1     2           2  1            |     16  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 4  1  1  4           2  4  2  1  2     3  3        3        2  4  2     1|     30  2.3|
      Cyst                                 |                                        2                                 |      1  2.0|
      Hyperplasia                          |    3  2     4     2  4        2  3  3  3        2  1        3           2|     24  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1  2              3  1        2                          3        1   |     11  1.8|
      Follicle, Hyperplasia                |                                           1                              |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                    3                     |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation                         |                                                    3                     |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X           X                       X     X  X                 X  X|     13     |
      Interstitial Cell, Hyperplasia       |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     | 3           1        1     1  3  1              3           1            |     20  1.9|
      Endometrium, Hyperplasia, Adenomatous| 3                                                                        |      1  3.0|
      Serosa, Inflammation, Granulomatous  |    1                                                                     |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Erythroid Cell, Hyperplasia          |                                  1  1                                    |      6  1.0|
      Myeloid Cell, Hyperplasia            |                      3           3  1        2        2     2     1      |     13  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                  +                       +               |   8        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                          2               |      1  2.0|
      Pancreatic, Hemorrhage               |                                                                          |      2  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.3|
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |      2  3.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Infiltration Cellular, Plasma Cell   |                                  2                                       |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1  2  1  2  1  2  1  1  2  1  1  2  1  2  1  1  1  1  1  1  1  1  1  1  1|     49  1.4|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1     1  1  1     1  1  1  1  1  1     1  1  1  1  1|     45  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1|     50  1.0|
      Lymphoid Follicle, Atrophy           |          1                          3  1                 2               |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 3  3     4  3  3  3  3  4  3  3  4  4  3  3  4  4  3  3  4  3  3  3  3  4|     48  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                  4     3                                 |      3  3.7|
      Hyperplasia                          |    2                       3                          1                  |      4  2.0|
      Inflammation                         |                                           1                              |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation                         |                                                       1                  |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Necrosis                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Inflammation, Granulomatous          |                1                       1                                 |      5  1.0|
      Alveolar Epithelium, Hyperplasia     |    1              2     1  1  1        1  1  1              1        3  3|     18  1.4|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |          1     1                    2                                    |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |             3                                                            |      1  3.0|
      Lens, Cataract                       |             2                                                            |      1  2.0|
      Retina, Degeneration                 |             4                                                            |      2  2.5|
      Retina, Dysplasia                    |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphoid      |    1              1                                            1         |     10  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2|            |
                                           | 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Nephropathy                          | 1  1  1  1  1  2  2  2  2  2  2  1  1  1  1  1  2  1  1  1  2  1  2  2  2|     49  1.4|
      Cortex, Mineralization               |                                                                          |      1  1.0|
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  2     1  1  1  1  1  1|     49  1.1|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      2  1.5|
      Renal Tubule, Hyperplasia            |                                                                          |      1  4.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  3                                       |      1  3.0|
      Inflammation                         |    1                                                                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|             
                                           | 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       1                       1                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    1           1        1           2  1  1  X  1     2                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                 1                        |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          1     2         |             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X                 X        X        X        X              X         |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                      X  X                                      X  X      |             
      Fatty Change, Diffuse                |          2                                         3                     |             
      Hematopoietic Cell Proliferation     |             1     1     1     1                                          |             
      Hepatodiaphragmatic Nodule           |                X                                X     X              X   |             
      Inflammation, Chronic Active         |       1        1  1  1  1     1  1  1     2     2     1  2     1  1      |             
      Mixed Cell Focus                     |                   X                                                     X|             
      Necrosis                             |                            1                       1                     |             
      Bile Duct, Hyperplasia               |    1  1  2     1     1  1  1  2     1  1     4  1  3  1  1  1  1  1  3   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |    1  1  2  2  2     1  2     1  1  1  1  1     2     1     2  1  1     2|             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +     +                       +              +        +     +   |             
      Fat, Necrosis                        |          2     3                       2              1        2     3   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|             
                                           | 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Oral Mucosa                             |                                                                          |             
      Gingival, Inflammation               |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inflammation                         | 1                                                                        |             
      Acinus, Atrophy                      | 1     1     1  2        1                    1              1            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                1         |             
      Basophilic Focus                     |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                            1                                             |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                            2                                             |             
      Inflammation                         |                            2                                             |             
      Mineralization                       |                         1                                                |             
      Epithelium, Atrophy                  |             2                                                            |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Inflammation                         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2  1  1  1  1  2  2  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  1  1  1        1  1           1                 1  1     1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|             
                                           | 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                   1                                                      |             
      Hyperplasia                          |          4  1           1  4           1                 1               |             
      Hypertrophy                          |                         1                                            1   |             
      Necrosis                             |                                              1                       2   |             
      Vacuolization Cytoplasmic            | 2        2        1  1     4           1  1        2  1  1        1  2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         4|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2     2        3     2  2     3  1     1     1     3     2  2         |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    2     3  2                    4  1     4     2        3  3  3  1      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1                             1              2  1      |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4                     |             
      Cyst                                 |                                                                3         |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                 3              3         |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X  X                             X                    X   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|             
                                           | 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |    2  2  2     2           1                 2        1  4  2        1   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Necrosis                             |                                                                          |             
      Erythroid Cell, Hyperplasia          | 2           3                                2                           |             
      Myeloid Cell, Hyperplasia            | 2           2     4        3                 2     3                 3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +  +     +        +                                         +   |             
      Axillary, Right, Ectasia             |                   3                                                      |             
      Axillary, Right, Infiltration        |                                                                          |             
          Cellular, Plasma Cell            |                   4                                                      |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |          3  2                                                            |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |          1                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  2  3  3  2  1  1  2  2  2  2  2  1  1  2  1  1  1  1  2  1  1  1|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                         X|             
      Autolysis                            |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  1  1  1  2  1  3  1  1  1     1  1  1  1  1  1     1  1  1  1        1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|             
                                           | 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Atrophy                              |    3  3  3  3  3  4  3  3  4  3  3  4  3  3  4     4  3  3     4  3  4  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                   4                                            4         |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +                             +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                      1                                                   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Granulomatous          | 2                 1                             1                        |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                1     1  1  2  1           1     1                       2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2|             
      Interstitium, Fibrosis               |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|             
                                           | 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            1        2                                    |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                   +           +                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               1                                          |             
      Lens, Cataract                       |                               2                                          |             
      Retina, Degeneration                 |                               4              2                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      |    1                             1     1                 1        1      |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 3                             2                                          |             
      Infarct                              |             X                                                            |             
      Nephropathy                          | 1  2  1  2  1  2  1  2  3  2  1  1  1  1  1  2  4  1  2  2  2  1  2  1  2|             
      Cortex, Mineralization               |                         1                                                |             
      Medulla, Mineralization              | 1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  2  1  2|             
      Pelvis, Inflammation                 |             2           2                       1                        |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                         2                       2                        |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2|            |
                                           | 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       1              1                       1        1     1            |     14  1.2|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                  1                                       |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        1                    2  1         |      5  1.4|
      Basophilic Focus                     | X  X  X           X  X  X  X  X  X     X     X  X  X  X     X  X  X  X  X|     41     |
      Clear Cell Focus                     | X     X                                                     X        X   |     10     |
      Degeneration, Cystic                 |                            1              3     1                        |      3  1.7|
      Eosinophilic Focus                   |                                                 X           X            |      6     |
      Fatty Change, Diffuse                |    1     4  3  2           2     1        1                              |      9  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      4  1.0|
      Hepatodiaphragmatic Nodule           |             X                                      X                     |      6     |
      Inflammation, Chronic Active         |    1  1     1        2  1     1  1     2           2  1     1  1  1  2  2|     29  1.3|
      Mixed Cell Focus                     |                         X                          X  X                  |      5     |
      Necrosis                             |    1     1     1           1        3     4     1        4           1   |     11  1.7|
      Bile Duct, Hyperplasia               | 1  1  1  2  1  2  3     2  2  1  1     1  1  1  2  1     1  1  1        2|     39  1.4|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      | 1                    1  1     1  1     1           1  2     1  2  1     2|     30  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2|            |
                                           | 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                       +                    +        +                  |  10        |
      Fat, Necrosis                        | 2                       1                    1        1                  |     10  1.8|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |             +     +        +              +                              |   4        |
      Gingival, Inflammation               |             1     1        1              1                              |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                        1                                 |      1  1.0|
      Inflammation                         |                      1                                                   |      2  1.0|
      Acinus, Atrophy                      |       1                    2              4        1                     |     11  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|
      Basophilic Focus                     |                            1                                             |      1  1.0|
      Inflammation                         |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |             2                             2                              |      2  2.0|
      Inflammation                         |                                           2                              |      2  1.5|
      Ulcer                                |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation                         |          1                                                               |      2  1.5|
      Mineralization                       |                                              1                           |      2  1.0|
      Epithelium, Atrophy                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                         +                          +                     |   3        |
      Inflammation                         |                         2                          2                     |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2|            |
                                           | 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  2  1  1  2  1  1  2  1  2  2  1  1  2  2     2  1  1  2  2  1  2  1|     48  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             1        1        1  1     1           1  1     1            |     18  1.0|
      Degeneration, Cystic                 |       1     1                                                            |      2  1.0|
      Hematopoietic Cell Proliferation     |                                           1                              |      2  1.0|
      Hyperplasia                          |                                                                          |      6  2.0|
      Hypertrophy                          |                               1              1              1            |      5  1.0|
      Necrosis                             |                2           1                    1                        |      5  1.4|
      Vacuolization Cytoplasmic            |          2                 2              2                              |     15  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                      1   |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    4     2  4  3     1              2              4           2  3  2  2|     23  2.3|
      Cyst                                 |       1                                                                  |      1  1.0|
      Hyperplasia                          |          3           3     1                          2     2  4  4  4  4|     20  2.8|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 3     1  2     2              1        2     1     4        1            |     13  1.7|
      Follicle, Cyst                       |                      1                                                   |      1  1.0|
      Follicular Cell, Hyperplasia         |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2|            |
                                           | 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |                                                       3        2         |      2  2.5|
      Inflammation                         |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   X     X                    X  X           X     X      |     10     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |       2     1        1  4              3  3        4  2     4        1   |     20  2.2|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                +                                                         |   1        |
      Inflammation                         |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                             1            |      1  1.0|
      Myelofibrosis                        |                1                                2                        |      2  1.5|
      Necrosis                             |          2                                                               |      1  2.0|
      Erythroid Cell, Hyperplasia          | 1                                   2                          2     1   |      7  1.9|
      Myeloid Cell, Hyperplasia            | 2        2     4  4        3        3     4     1        2     1  2  1  2|     20  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +     +  +                 +     +                    +         |  11        |
      Axillary, Right, Ectasia             |                                                                          |      1  3.0|
      Axillary, Right, Infiltration        |                                                                          |            |
          Cellular, Plasma Cell            |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                     2     2                              |      4  2.3|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2|            |
                                           | 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Plasma Cell   | 2                                                                        |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  2  1     1     1  1  1  1  2  2  1  2  1  1  2  2  1  1  1  3  2  1  1|     48  1.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Autolysis                            |                                     X                    X               |      2     |
      Hematopoietic Cell Proliferation     | 1     1        1  1  1  1  1  1  1  4  1  1        1  1  1  1  1     1  1|     40  1.2|
      Hyperplasia, Lymphoid                |                                                                      3   |      1  3.0|
      Pigmentation, Hemosiderin            | 1  1  1  1  2  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1|     49  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              | 3     3  4  4  4  3  3        3  3  4  4  4  3  3  3  3  4  3  4  4  3  4|     44  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      2  4.0|
      Hyperplasia                          |                                        3                                 |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |          1                                                               |      1  1.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2|            |
                                           | 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |          1                                                               |      1  1.0|
      Hemorrhage                           |          1     1                                                         |      2  1.0|
      Inflammation                         |                                                                          |      1  1.0|
      Necrosis                             |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                      2   |      1  2.0|
      Inflammation, Granulomatous          | 1     1                                   4           1     1        1   |      9  1.4|
      Metaplasia, Squamous                 |                                     1                                    |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                      1  1              1        1  1                     |     13  1.2|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2|     50  2.0|
      Interstitium, Fibrosis               |                                           3                              |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                 1                        |      3  1.3|
      Thrombosis                           |          2                                               2               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                             1            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                         +                                                |   3        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                              3                           |      2  2.0|
      Lens, Cataract                       |                      1                                                   |      2  1.5|
      Retina, Degeneration                 |                      3                       3                           |      4  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2|            |
                                           | 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphoid      |                                                                         1|      6  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      2  2.5|
      Infarct                              |                                                                      1   |      2  1.0|
      Nephropathy                          | 2  1  2  1  2  2  2  1  2  3  2  2     1     2  1  1  1  1  1  2  4  2  3|     48  1.7|
      Cortex, Mineralization               |    1     1                                      1                        |      4  1.0|
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1|     49  1.1|
      Pelvis, Inflammation                 |                                                                      2   |      4  1.8|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      2  2.0|
      Renal Tubule, Hyperplasia            |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|             
                                           | 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             1                 1                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                1                                            1     1      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X  X  X  X  X  X        X  X  X     X     X|             
      Clear Cell Focus                     |                X              X     X  X                                 |             
      Degeneration, Cystic                 |    1              1                                2                     |             
      Eosinophilic Focus                   |                X           X  X                                   X      |             
      Fatty Change, Diffuse                | 1  1  1           1  2     1  1              1  4        1           1  1|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Chronic Active         |       1     1  1  1     1  1  2  2  2  2  1  1              1     2     1|             
      Mixed Cell Focus                     |                      X        X                                   X      |             
      Necrosis                             | 1  1     1        1                             2        2     1         |             
      Bile Duct, Cyst                      |                      X                                                   |             
      Bile Duct, Hyperplasia               | 2  3  1  1  1  1  2  2  1     1  1  2  1  2     3  3     2  1  3  1     1|             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |       2     2  2  2  3  2  3  1     2  2  2  2           2  2     1     2|             
      Oval Cell, Hyperplasia               | 1                                                                        |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +  +                                      +     +           +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|             
                                           | 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis                        |             1                                      3     3               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                +                                +                        |             
      Hyperplasia, Squamous                |                                                                          |             
      Gingival, Inflammation               |                1                                1                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inflammation                         |                      1              1                                    |             
      Acinus, Atrophy                      |    1           1     1  1     1                 4     1     1        1   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                  1              1                        |             
      Inflammation                         |                                                 1                        |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          2                                                               |             
      Inflammation                         |                                              1                           |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1  1  1  2     1  1  2  2  1  1  1  2  2  2  1  1  1  1  1  2  1  2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|             
                                           | 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1  1     1     1     1  1  1  1     1  1  1        1                  |             
      Atrophy                              | 2                                                                        |             
      Hematopoietic Cell Proliferation     |                         1                                                |             
      Hyperplasia                          |       1              1        1        1                                 |             
      Hypertrophy                          |       1        1                       1                 1               |             
      Necrosis                             |                                                 2                        |             
      Vacuolization Cytoplasmic            | 1  1  2  1        1        1        1           2  2                 1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     1     1        2     4     4  3  2     2  2  2        1  1  3  1  2|             
      Cyst                                 |                                                       2  2               |             
      Hyperplasia                          | 3        2  2        1                    1     2  4                 2   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2           1                          3                                 |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X     X        X                                                      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                              2                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|             
                                           | 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation                         |                                                                          |             
      Cervix, Hypertrophy                  |                                     3                                    |             
      Endometrium, Hyperplasia, Cystic     |    4  1     4  1     1     1     1     2  3  1  2                        |             
      Endometrium, Hyperplasia, Adenomatous|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Myelofibrosis                        |          2                                         1           2         |             
      Necrosis                             |                                                 2                        |             
      Erythroid Cell, Hyperplasia          |                                                    1                     |             
      Myeloid Cell, Hyperplasia            | 3  3     3           1                             2  4        3     2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                          +  +              +        +|             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Plasma Cell                     |                                                                         2|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                         2|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                         1|             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                2         |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                              3                           |             
      Renal, Pigmentation                  |                                              2                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                      1   |             
      Infiltration Cellular, Histiocyte    | 3  1  1  2  1  1  1  1  1  1  1  3  3  1  1  1  1  1  1  2  1  3  1  1  2|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |                                                                1         |             
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  2  1  2  2  1  1  1     1  2  1  1  1  1  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|             
                                           | 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia, Lymphoid                | 4                                                                        |             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Red Pulp, Hyperplasia                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  4  3  3  3  3  4  4  3  3  3  4  3  3  3  4  3  3  4  3  3  4  3  4  4|             
      Cyst                                 | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
      Galactocele                          |                                              4                 X         |             
      Hyperplasia                          |                                     2        2                           |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                      2  1|             
      Alveolar Epithelium, Hyperplasia     |          1        1                                      2     2  2  1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|             
                                           | 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Optic Nerve, Fibrosis                | 2                                                                        |             
      Retina, Degeneration                 |          3                                                               |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      | 1                                      1                    1           1|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                      4   |             
      Infarct                              |                                                                X         |             
      Nephropathy                          | 2  2  3  3  2  2  1  2  1  3  1  3  4  1  2  2  1  2  1  1  2  1  2  2  2|             
      Cortex, Inflammation                 |                                                                          |             
      Cortex, Mineralization               |                                                                          |             
      Medulla, Mineralization              | 1  1  1  2  1  1  1  1  1  1  1  2  1     1  1  1  1  1  1  1  1  1  1  1|             
      Pelvis, Inflammation                 |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |       1                                                                  |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7|            |
                                           | 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                               1                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    1                          1           1                              |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                           1                              |      1  1.0|
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X|     43     |
      Clear Cell Focus                     |                         X              X  X  X                 X     X   |     10     |
      Degeneration, Cystic                 | 1                                                                        |      4  1.3|
      Eosinophilic Focus                   |             X        X        X           X                       X      |      9     |
      Fatty Change, Diffuse                |          1  1     1  1              3           1  2        3            |     20  1.5|
      Fibrosis                             |                            3                                             |      1  3.0|
      Hematopoietic Cell Proliferation     |                                           1                              |      2  1.5|
      Hepatodiaphragmatic Nodule           |          X     X              X                                X     X   |      6     |
      Inflammation, Chronic Active         |    2  1  2     3     1        1  1     1  1     1     1  1     2     2  1|     30  1.4|
      Mixed Cell Focus                     |                               X                       X                  |      5     |
      Necrosis                             | 1        1  1              2                                1            |     12  1.3|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 4     1  2  2        1  1     2  1  3  1  1  1  1     2  1  2  1  1  2   |     40  1.6|
      Hepatocyte, Centrilobular,           |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7|            |
                                           | 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Hypertrophy                      |    2  1  2     2     3  2     2  2     2  2  1  2     2  3     2  2  2   |     33  2.0|
      Oval Cell, Hyperplasia               |             1              4                                             |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   6        |
      Fat, Necrosis                        |                               1                                          |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +                                   +                                    |   4        |
      Hyperplasia, Squamous                |                                     2                                    |      1  2.0|
      Gingival, Inflammation               | 1                                   2                                    |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                    1                     |      1  1.0|
      Inflammation                         |                1                                1        1     1         |      6  1.0|
      Acinus, Atrophy                      | 4                 1                                            1         |     12  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                    3                    4|      4  2.3|
      Inflammation                         |                                                    2                    4|      3  2.3|
      Ulcer                                |                                                    4                    3|      2  3.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation                         |                                                    2                    2|      3  1.7|
      Ulcer                                |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                  +  +                                    |   3        |
      Inflammation                         |                                  2  2                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7|            |
                                           | 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Mineralization                       |                                                    1                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  1  1  1  1     1  2     2  2  1  1  2  1  1  1  1  2  1  2  2  2  1|     46  1.4|
      Atrium, Thrombosis                   |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         1     1     1  1  1  1  1     1  2     1     1   |     24  1.0|
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                 1                        |      2  1.0|
      Hyperplasia                          |                                                 2              1         |      6  1.2|
      Hypertrophy                          | 1     1        1           1                                             |      8  1.0|
      Necrosis                             |             3                                                            |      2  2.5|
      Vacuolization Cytoplasmic            | 1              1  2           1     1  2     1     2     1  1            |     20  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Hyperplasia                          |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       1        4                             1        2  2        2     1|     23  2.0|
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia                          |                      2  3     1           2  3        1  2  1        1  2|     18  1.9|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    2                 4        1                 1                       1|      8  1.9|
      Follicle, Cyst                       |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7|            |
                                           | 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                 2                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                X                 X     X     X           X           X   |      9     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Inflammation                         |                               2                                          |      1  2.0|
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                      4  3           2  2     4  4     2           2  1   |     20  2.3|
      Endometrium, Hyperplasia, Adenomatous|                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                            1                                             |      1  1.0|
      Myelofibrosis                        |    1        2                                                           1|      6  1.5|
      Necrosis                             |                                                                          |      1  2.0|
      Erythroid Cell, Hyperplasia          |                      2                                                   |      2  1.5|
      Myeloid Cell, Hyperplasia            |             2        2     4        3                                    |     13  2.6|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +        +     +  +                 +              +        +            |  12        |
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Plasma Cell                     |                                     1                                    |      2  1.5|
      Mediastinal, Hemorrhage              |                3                                   3                     |      2  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                    2                     |      2  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7|            |
                                           | 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Plasma Cell   |                                                    3                     |      2  2.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  3  2     1  3  2  1  1  2  1  1  1  1  1  1  1  2  1  1  1  3|     49  1.4|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                             2            |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |    1  1  1     1  1  1  1  2  1  1  1  1  1  1  1     1  1     1  1  1  1|     45  1.1|
      Hyperplasia, Lymphoid                |                            1                                             |      2  2.5|
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     49  1.0|
      Red Pulp, Hyperplasia                |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 4  3  3  3     3  4  4  3  3  3  3  4  3  3  4  3  4  3  4  3  3  3  3  4|     49  3.3|
      Cyst                                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Galactocele                          |                                                                          |      2  4.0|
      Hyperplasia                          |                                           2                              |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                            X                                             |      1     |
      Sebaceous Gland, Hyperplasia         |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7|            |
                                           | 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                         1|      2  1.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |             3        1  1              1                                1|      7  1.4|
      Alveolar Epithelium, Hyperplasia     |    1                 1  1        1        1     1     1           2  1   |     15  1.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  2  2  2  1  2  2  2  1  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  1.9|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                1         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                   1      |      1  1.0|
      Lens, Cataract                       |                                                                4        3|      2  3.5|
      Optic Nerve, Fibrosis                |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                  1                             4        4|      4  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphoid      |    1                    1              1                 2           1   |      9  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7|            |
                                           | 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1     |
      Nephropathy                          | 2  2  2  1  2  4  2  3  2     2  2  1  2  3  2  1  4  2  2  1  2  2  2  4|     49  2.0|
      Cortex, Inflammation                 |                                  2                                       |      1  2.0|
      Cortex, Mineralization               |                      1                                                   |      1  1.0|
      Medulla, Mineralization              | 1     1  1  2  2  1  2  1  1  1  1  1     1  1  1  2  1  1  1  1     1  1|     46  1.1|
      Pelvis, Inflammation                 |                            1     2                                       |      2  1.5|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                1     1                             1                     |      4  1.0|
      Renal Tubule, Cyst                   |                                                                         X|      1     |
      Renal Tubule, Hyperplasia            |                                                                         4|      1  4.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|             
                                           | 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X  X  X                       X  X     X     X     X  X      |             
      Clear Cell Focus                     | X  X     X  X     X        X              X  X                 X         |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                1        1                                      1        1|             
      Eosinophilic Focus                   |                X                                         X               |             
      Fatty Change, Diffuse                |    1  3              1  1        2  2  4        3                    4  1|             
      Hematopoietic Cell Proliferation     |                2                       1                 1               |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Inflammation, Chronic Active         | 2  2     2        2        2                 2  1  2     2     2     2   |             
      Inflammation, Granulomatous          |                                                                   4      |             
      Mixed Cell Focus                     |    X        X                             X        X                     |             
      Necrosis                             |                1        2        1  1  2     1        3           1     1|             
      Bile Duct, Hyperplasia               | 2  2  3  1  2  1  1  2  2  2  3  3  2  1  2  2  1  2  2  2  1  2  3  2  3|             
      Hepatocyte, Multinucleated           |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                             +     +           +        +      |             
      Inflammation                         |                                                                   2      |             
      Fat, Necrosis                        |          2                                   2           2               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|             
                                           | 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Oral Mucosa                             |                                                                +         |             
      Gingival, Inflammation               |                                                                1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             2                       1              1     2        4      |             
      Acinus, Atrophy                      |    2        1        1                    1        2     1           1  1|             
      Acinus, Hyperplasia                  |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                    1                 2   |             
      Inflammation                         |                               1                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       1                                2                                1|             
      Inflammation                         |                1                                                  4      |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  3  2  1  2  2  1  1     3  3  2  3  1  1  3  2  2     2  2  2  2|             
      Atrium, Thrombosis                   |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|             
                                           | 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Cytoplasmic Alteration               |                                                                   2      |             
      Degeneration, Cystic                 |                                                                   1      |             
      Hematopoietic Cell Proliferation     |          1                       1     1                                 |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |    1                    2     1     2                                   1|             
      Necrosis                             |                                                       4                  |             
      Vacuolization Cytoplasmic            |       3     1           1  1  1  2  2  2  1     3           1           2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            4              4                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                  3        1|             
      Cyst                                 |    1  1           1              1                                       |             
      Hyperplasia                          |    2        4  1           2  3        1  4     1                        |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1                                                                        |             
      C-Cell, Hyperplasia                  |       1              1              3  1  1     1                 4  3  1|             
      Follicle, Degeneration               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|             
                                           | 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation                         |                                                    1  3           2      |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                                       |             
      Inflammation                         |                                                 4                        |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      3                                         3         |             
      Hyperplasia                          |                                                          1               |             
      Inflammation                         |       1     1  1              1     2           2     1        1  3  1   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
      Inflammation                         |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                                     2           4                 4     2|             
      Interstitial Cell, Hyperplasia       |             1        2              1  3        1           3  2  1     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |    2     2           2           2  2  2  2              1        2      |             
      Myeloid Cell, Hyperplasia            |                      3  4     4  2  2     2     3        2  4     3     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +           +     +     +  +  +  +              +     +           +|             
      Deep Cervical, Ectasia               |       2                                                                  |             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                  2                                       |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  +  +  M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M|             
      Ectasia                              |                                                                4         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|             
                                           | 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1                                                      |             
      Ectasia                              |                   2                                      1        4      |             
      Infiltration Cellular, Histiocyte    | 1  1  1  2  2  1  1  1  1  2  1  1  1  1  1  1  1  2  1  1     1     1  1|             
      Inflammation                         |                                                                   4      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               2                                          |             
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  2  1  2     1  1  2  2  3  2  1  1  1  2  1  1  1  1  2  1|             
      Hyperplasia, Lymphoid                | 2                                                        4               |             
      Inflammation, Granulomatous          |                                                                   2      |             
      Necrosis                             |                      2                                                   |             
      Pigmentation, Hemosiderin            | 1  1     1  1     1  1  1  1  1  1  1     1  1  1  1  1  1  1  1     2   |             
      Lymphoid Follicle, Atrophy           |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  4  4  2  3  4  4  3  4  3  4  4  4     4  4  4  4  4  4     4  4  4  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          3                                                               |             
      Galactocele                          |                      1                                                   |             
      Inflammation                         |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Degeneration                         |                                                                          |             
      Inflammation                         |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|             
                                           | 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3                                               2|             
      Necrosis                             |                                  2     2                                 |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                     +                                    |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                     1                                1   |             
      Inflammation, Granulomatous          |                               1                                          |             
      Necrosis                             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1  1        1              1           1     2           2        1  1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  2  2  2  2  2  2  1  2  2  1  2  1  2  2  2  1  2     2  2  2  1  2  1|             
      Bronchiole, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2                       1                 2     2              2   |             
      Thrombosis                           |                                                                   2      |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                   2      |             
      Respiratory Epithelium, Hyperplasia  |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iris, Fibrosis                       |                                  3                                       |             
      Iris, Inflammation                   |                                  1                                       |             
      Lens, Cataract                       |                      3           3                                       |             
      Lens, Mineralization                 |                                  2                                       |             
      Retina, Atrophy                      |                                  2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|             
                                           | 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Retina, Degeneration                 |                      4           4  1                                    |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphoid      | 1                          2                 1              1            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                      3  1                                         2      |             
      Infarct                              |                         1                                                |             
      Nephropathy                          | 1  2  2  1  1  1  1  1  1  1  1  2  4  1  2  1  1  1  1  1  1  1  1  1  1|             
      Medulla, Mineralization              | 1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                     1                                    |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |       4                                                                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     3  1                          1      |             
      Muscularis, Degeneration             |                                                                   1      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | 1  1                    1                       1     1                  |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X           X  X        X  X     X     X  X  X  X        X     X      |     24     |
      Clear Cell Focus                     |    X           X              X     X     X  X  X  X        X     X      |     19     |
      Congestion                           |                                              2                           |      1  2.0|
      Degeneration, Cystic                 |       1  1  3                 1                                          |      8  1.3|
      Eosinophilic Focus                   |                         X                    X        X                  |      5     |
      Fatty Change, Diffuse                | 2     4  2  3     4        1     2     2                 1        1  2  4|     22  2.3|
      Hematopoietic Cell Proliferation     |                                                       1                  |      4  1.3|
      Hepatodiaphragmatic Nodule           |          X                                                               |      2     |
      Inflammation, Chronic Active         |    2           1     1        2     2     2  2  2  2        2     2      |     22  1.9|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                X           X  X              X     X                     |      9     |
      Necrosis                             | 1     1  1                    1  1     2                 1     2     2  3|     19  1.5|
      Bile Duct, Hyperplasia               |    2  2  2  3  3  2  1  3  2  3  3  2  2  2  2  2  1  2  3  1  3  2  4  2|     49  2.1|
      Hepatocyte, Multinucleated           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |          +                          +        +                    +      |   9        |
      Inflammation                         |                                                                          |      1  2.0|
      Fat, Necrosis                        |          3                          3        2                    2      |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |          +                             +  +           +        +     +  +|   8        |
      Gingival, Inflammation               |          1                             1  1           1        1     1  1|      8  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                         2     1     1  2  1     1        1        1  1   |     14  1.5|
      Acinus, Atrophy                      | 1        4     2     1  1  1           1     1  1                 1  1  1|     20  1.3|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                           1                              |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |          2        3  2                 2                             2   |      7  2.0|
      Inflammation                         |          2  2     2  2                 2                       3     2   |      8  2.0|
      Ulcer                                |          1  3     3  3                                                   |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |             2        1                                                   |      5  1.4|
      Inflammation                         |             2                                                  2     2   |      5  2.2|
      Ulcer                                |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |    +                                                                     |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +        +                                                            |   3        |
      Inflammation                         |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  3  2  1  2  2  1  1  2  2  2  3  1  1  2  2  2  1  2  2  2  1  2  2  3|     48  1.9|
      Atrium, Thrombosis                   |       3     3                                                            |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              1  1  1        1            |      4  1.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |             1                                               1            |      5  1.0|
      Hyperplasia                          |                                                          1               |      1  1.0|
      Hypertrophy                          |    1                          1                                         2|      8  1.4|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            | 3     2  2  2     1  1  1  1  1  2     3           1     1  1  1         |     27  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     1              1                                4                  |      6  2.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                              1              2            |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2                                                            |      4  2.0|
      Cyst                                 |          1                                                           1   |      6  1.0|
      Hyperplasia                          |          1  3  2        1              3              1     2     2      |     16  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |       1  3     3  4     4     1     1     1                              |     17  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Follicle, Degeneration               |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                 +                        |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |          1                                                               |      1  1.0|
      Inflammation                         |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation                         |                                                       4                  |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                                         1                     |      4  2.3|
      Hyperplasia                          |                                           1                              |      2  1.0|
      Inflammation                         |    1  2           2                          1  1     1  3     3         |     18  1.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                                         1                     |      3  1.7|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Degeneration    |       1                    4                                             |      6  2.8|
      Interstitial Cell, Hyperplasia       | 2     3                 2  1                                   2     2   |     15  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Erythroid Cell, Hyperplasia          |                         2        2  1        2                           |     13  1.8|
      Myeloid Cell, Hyperplasia            | 4  1  2  2              2        1                       3     4     3  4|     21  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |             +                    +     +              +  +  +  +     +  +|  19        |
      Deep Cervical, Ectasia               |                                                                2         |      2  2.0|
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Plasma Cell                     |                                                                2         |      1  2.0|
      Mediastinal, Ectasia                 |             3                                         2     2            |      3  2.3|
      Mediastinal, Hemorrhage              |                                                       1                  |      1  1.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                  1                                       |      2  1.5|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M|   5        |
      Ectasia                              |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|
      Ectasia                              |                                                             1            |      4  2.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  2  1  2  1  2  1  2  1  1  2  1  1  1  1     1  1  1  2  1|     47  1.2|
      Inflammation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 1  1     1  1  1     1  2  1  1     1  1  1  1  1  1  1  1  1  1  1  1   |     45  1.2|
      Hyperplasia, Lymphoid                |    2           1                    2              1                     |      6  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |    1  1  1  1  1  3  1  1  2  1  1  1     1  1  1  1  1     1     1      |     39  1.1|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Atrophy                              | 3  3  4  3  4  3  4     4  4  4  4  3  4  3  4  3  3        3     4  4  4|     44  3.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Galactocele                          |       1                                                                  |      2  1.0|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                              1                 2         |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   2        |
      Degeneration                         | 2                                                                        |      1  2.0|
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |       1                                                        1        2|      5  1.8|
      Necrosis                             |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Inflammation, Granulomatous          |                                                                         1|      2  1.0|
      Necrosis                             |                                                                2         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    1  1                    1  3              2     1              2      |     16  1.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  2  2  2  1  1  1     2  2  2  2  1  1  2  2  2  2     1  2     2  3  3|     46  1.7|
      Bronchiole, Hyperplasia              |                                                                1         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 2                                                                       3|      7  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   |             1                                                            |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                            1                             1               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iris, Fibrosis                       |                                                                          |      1  3.0|
      Iris, Inflammation                   |                                                                          |      1  1.0|
      Lens, Cataract                       |                                                                          |      2  3.0|
      Lens, Mineralization                 |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  2.0|
      Retina, Degeneration                 |             1                                                           1|      5  2.2|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                                                               |      1  1.0|
      Infiltration Cellular, Lymphoid      |                1                       1  2        1              1      |      9  1.2|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                1                                                         |      4  1.8|
      Infarct                              |                                                                          |      1  1.0|
      Nephropathy                          | 2  2  2  1  1  2  2  1  2  2  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     50  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7|            |
                                           | 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1     1  1  1  1     1  1  2  1  1  1  1  1  1  1  1|     47  1.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                                                      1   |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      3  1.7|
      Muscularis, Degeneration             |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|             
                                           | 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                1                          1                          2   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X        X  X     X     X     X  X              X        X     X  X   |             
      Clear Cell Focus                     | X  X                       X     X  X              X        X        X  X|             
      Degeneration, Cystic                 |       1     1                       1  1                          1      |             
      Eosinophilic Focus                   |                X  X  X              X     X        X              X     X|             
      Fatty Change, Diffuse                |    1  2  3              1                    3  1        1  1        1   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Inflammation, Chronic Active         | 2  1                       1     1                       2  2     2  2   |             
      Mixed Cell Focus                     | X  X           X           X                       X        X            |             
      Necrosis                             |          1  1  2        1              2     3        1        3         |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  2     2  3  3  3  3  2  1  2  2  2  3  2  1  2  2  2  2  2  2  2   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |    1           1           1     2  1              2     1  1        2  1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +        +           +  +                 +           +      |             
      Fat, Necrosis                        |             2        2           3  1                                    |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|             
                                           | 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Oral Mucosa                             |                +                          +     +     +                  |             
      Gingival, Inflammation               |                1                                1     1                  |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inflammation                         |    1           1  1     1     1           1     1  1                     |             
      Acinus, Atrophy                      | 1           1        3           1     1        1        1  1     1      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation                         |                2     4                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       X                                                                  |             
      Hyperplasia, Squamous                |                                        2        2                    1   |             
      Inflammation                         |       1                                3        3                        |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       3                                                                  |             
      Inflammation                         |                         1              2        2                        |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  2     2  2  3  2  1  3  2  3  3  2  2  1  3  2  1  2  3  2  3  3  2|             
      Aorta, Tunic, Media, Mineralization  |                                                                          |             
      Atrium, Thrombosis                   |             2                                                            |             
      Endocardium, Hyperplasia             |                                                    4                     |             
      Valve, Thrombosis                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|             
                                           | 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                 2                                             |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                2                                                         |             
      Hypertrophy                          |                   1                                                      |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |          3  2  1     1  2  2     1           2  1  2  2  1        2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |             4  1  1              1                          3            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1                 3           2  3           2  1   |             
      Cyst                                 | 1                                                                        |             
      Hyperplasia                          | 1  3           2     2     1                       3     1  1  3  4  1   |             
      Inflammation                         |                                                       2                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4                                1        1                              |             
      Follicle, Cyst                       | 2                                                                        |             
      Follicle, Degeneration               | 1                    1                                                   |             
      Follicular Cell, Hyperplasia         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|             
                                           | 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          3               |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                 1     1     1     1                                2|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |             2           1  1     1     2  1     1  1        1  1         |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                 1     1     1     1                                1|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          4                                                               |             
      Necrosis                             |          4                                   4                           |             
      Germinal Epithelium, Degeneration    |                                                    4  4                  |             
      Interstitial Cell, Hyperplasia       |                      2        3        3           1  3        1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Necrosis                             |                                                 2                        |             
      Erythroid Cell, Hyperplasia          |                   1                                                      |             
      Myeloid Cell, Hyperplasia            |          3  3  2  3  3  4     2           2  4     2     1     4     1  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +  +        +  +     +              +  +  +  +        +         |             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                 2                        |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|             
                                           | 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  1                                       |             
      Infiltration Cellular, Histiocyte    | 2  1        2  2  2  3  1  1  1  2  1  1  2     2  1     2  3  1  2  2  1|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |             X                                                            |             
      Autolysis                            |       X                                                                  |             
      Hematopoietic Cell Proliferation     | 1  1     1  1  1  1  2  1  1     1  1     1  1  1  1  1  1  1  1  1  2  3|             
      Hyperplasia, Lymphoid                |    2                                                                 2   |             
      Inflammation, Granulomatous          |                      3                                               3   |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1     1  1     1  1  1|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  3  3  3  3     4  3  4  3  4  4  4  4        3  3  4  3  4  4|             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
      Subcutaneous Tissue, Inflammation    |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                                               |             
      Necrosis                             |                                                 2                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|             
                                           | 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |          3              1                                                |             
      Inflammation, Granulomatous          |                   3                 1                          3         |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   1              3                                       |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1     1  2  2  1  1  1  1     2  1  1  1     1  1  2  2  1  3  2  2  1|             
      Bronchiole, Hyperplasia              |                                           1                       3  2   |             
      Interstitium, Fibrosis               |                         2                                                |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1                    3              2  2         |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Degeneration                 |                         1                                                |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      |                      1                                               1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                    2                     |             
      Infarct                              |                                                       X                  |             
      Nephropathy                          | 3  1        2  2  2  2  2        3  3  4  2     4  3  1  1  4  1  2  3  2|             
      Cortex, Mineralization               |                                                                          |             
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  2  1  1  1  1  2  1  1     1  1  2  1  1  2  1  1|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     | 1                    1                 1        1           1            |             
      Renal Tubule, Hyperplasia            |                                     1                                1   |             
      Renal Tubule, Pigmentation           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|             
                                           | 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    312 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                          X               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5|            |
                                           | 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                         1|      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             1                       1              1                     |      6  1.2|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             3                                                            |      1  3.0|
      Basophilic Focus                     | X  X  X           X     X        X     X  X     X  X  X        X  X      |     25     |
      Clear Cell Focus                     | X     X        X  X              X     X  X     X     X           X      |     19     |
      Degeneration, Cystic                 | 1        1  1                 1           1                    1         |     11  1.0|
      Eosinophilic Focus                   | X  X        X        X  X                          X                     |     14     |
      Fatty Change, Diffuse                | 1     1  2                 4  1  2           2     1        1  2     3   |     20  1.7|
      Hematopoietic Cell Proliferation     |                                                                2         |      1  2.0|
      Hepatodiaphragmatic Nodule           |    X     X     X                 X        X                              |      6     |
      Inflammation, Chronic Active         | 2  1  1        2  1     2        2     1  2     2  2  1           2      |     21  1.6|
      Mixed Cell Focus                     | X  X  X     X  X  X              X     X        X  X              X      |     17     |
      Necrosis                             | 1        3           1     2  1  1           1           3  1  1     2   |     19  1.6|
      Bile Duct, Cyst                      |                                                                X         |      1     |
      Bile Duct, Hyperplasia               | 1  1  2  3  3  2  2  3  1     4  2  2  2  2  3  2  2  1  2     1  2  2  3|     46  2.1|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      |       1        2  1     1                 1     1  2                     |     17  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5|            |
                                           | 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +           +                    +  +  +        +               |  12        |
      Fat, Necrosis                        |                      1                    3     1                        |      7  1.9|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +  +           +              +                                       |   8        |
      Gingival, Inflammation               |    1  1           1                                                      |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       3                                                                  |      1  3.0|
      Inflammation                         |                      3        1  1  1  1           1                 2  1|     16  1.2|
      Acinus, Atrophy                      |          1  1  1     1           1  1     1     1  1              1  2  1|     21  1.1|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                     1                                    |      1  1.0|
      Inflammation                         |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Autolysis                            |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                      2   |      4  1.8|
      Inflammation                         |                               2              1                       2   |      6  2.0|
      Mineralization                       |          1                                                               |      1  1.0|
      Ulcer                                |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                               1                                          |      2  2.0|
      Inflammation                         |                               2                                      2   |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                               +              +           +  +            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5|            |
                                           | 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Mineralization                       |                                              1                           |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  3  2  1  1  2  2  1  1  1  1  2  3  2  2  1  2  2  2  2     2  2  3  2|     48  2.0|
      Aorta, Tunic, Media, Mineralization  |                                     1                                    |      1  1.0|
      Atrium, Thrombosis                   |          2                 2              4                    1         |      5  2.2|
      Endocardium, Hyperplasia             |                                           4                              |      2  4.0|
      Valve, Thrombosis                    |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                   1                                            1         |      4  1.3|
      Atrophy                              |                                           3                              |      1  3.0|
      Hyperplasia                          |          1  1     1                                                      |      4  1.3|
      Hypertrophy                          |                                                    1                     |      2  1.0|
      Necrosis                             |                                     1        1           1     4         |      4  1.8|
      Vacuolization Cytoplasmic            | 2        2  1     1  2     2  2              3     1  1     1  2  1  3   |     27  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       1                                                                  |      1  1.0|
      Hyperplasia                          |                                  2                             3     2   |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
      Hyperplasia                          |                                                                         1|      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      3  2              2                       1         |     10  2.0|
      Cyst                                 |             1                                   1                        |      3  1.0|
      Hyperplasia                          | 2  2  1     1  4     4        4  2        3        3                     |     21  2.3|
      Inflammation                         |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5|            |
                                           | 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       1        4        1                 1  3                           |      8  2.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicle, Degeneration               |                                                                          |      2  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation                         |             3                                   2                        |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1                                                         |      7  1.1|
      Hyperplasia                          | 1     1        2                                                         |      3  1.3|
      Inflammation                         |             1           1  1  1  1                 1                 2   |     17  1.2|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1                                                         |      7  1.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      2  4.0|
      Germinal Epithelium, Degeneration    |                4  4        2                                             |      5  3.6|
      Interstitial Cell, Hyperplasia       |                3  2     2  3                                3        2   |     12  2.3|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5|            |
                                           | 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Megakaryocyte           |                                                          2               |      1  2.0|
      Myelofibrosis                        |                                                                2         |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Erythroid Cell, Hyperplasia          |                                  1                             2         |      3  1.3|
      Myeloid Cell, Hyperplasia            |    1     2           3     3  4  1  2        3           2     2  2  3  4|     27  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +        +                 +  +              +           +  +  +     +  +|  20        |
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Plasma Cell                     | 2                                                              2         |      2  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                 1                        |      2  1.0|
      Infiltration Cellular, Histiocyte    | 2  2  1  1  1  1  2  1  2        1  1  1  2     1  2  2  1     2  1     1|     41  1.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Autolysis                            |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 1  1  1  2     1  1     1  1  1  1     1  1     1  1  1     1  2  1  2  1|     42  1.2|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Granulomatous          | 3                                                                        |      3  3.0|
      Necrosis                             |                               3                             2            |      2  2.5|
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1     1  1  1  1     1  1  1  1        1  1  1|     43  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 3  3  4  4  3  4  3  4  3     4  3  4  3        4  4  4  4     4  4     4|     42  3.6|
      Ectopic Parathyroid Gland            |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5|            |
                                           | 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   2        |
      Degeneration                         |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                            1  4              1              1            |      5  1.8|
      Necrosis                             |          1                    2                                      2   |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Granulomatous          |                               2                                          |      4  2.3|
      Thrombosis                           |                                                                2         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 1                                      2                       3         |      5  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2  2  2  2  2  2  1  1  1  1  1  2  1  1  2  1  2  2  1  1  1  3  2  1  1|     47  1.5|
      Bronchiole, Hyperplasia              |                                                                          |      3  2.0|
      Interstitium, Fibrosis               |                                                                1         |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                1        3                                1               |      7  1.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5|            |
                                           | 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    312 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Thrombosis                           |          3                 3                                             |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Retina, Degeneration                 |                      1                                                   |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphoid      |                                        1  1                              |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  2.0|
      Infarct                              |                      X                                                  X|      3     |
      Nephropathy                          | 3  3  3  2  4  3  2  4  1  1  1  4  2  3  3  1  4  2  3  1  1  3  4  1  2|     45  2.4|
      Cortex, Mineralization               |                                                             1            |      1  1.0|
      Medulla, Mineralization              | 1  1  1  2  1  1  1  1  1  1  1  1  1  2  1  1  1  1  2  1  2  1  1  1  1|     49  1.2|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |    2        2  1                 1     1                          1      |     11  1.2|
      Renal Tubule, Hyperplasia            |                3                 1                                1      |      5  1.4|
      Renal Tubule, Pigmentation           |                                                                      1   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|             
                                           | 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          1        1                                      1               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X  X     X  X  X     X     X  X     X  X  X  X        X     X|             
      Clear Cell Focus                     |             X  X  X  X  X        X  X  X  X              X        X      |             
      Degeneration, Cystic                 |    1     1              2  1           1        1  1     1           1   |             
      Eosinophilic Focus                   |    X     X           X                 X        X                 X      |             
      Fatty Change, Diffuse                | 1  1              1     1        1        1  2     2  3  2  1  2         |             
      Hematopoietic Cell Proliferation     |                                     1                             1      |             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Inflammation, Chronic Active         | 2  2     1  2  2  2  2  2  2     2  2  2  2     2  2  2  2  2     2      |             
      Mixed Cell Focus                     |    X        X  X  X     X  X     X  X  X  X     X  X                     |             
      Necrosis                             |                               3              1                 2     1   |             
      Bile Duct, Hyperplasia               | 2  2  3  2     1  2  2  1  1  3  2  2  2  2  3  2  2  2  2  2  2  2  3  2|             
      Hepatocyte, Multinucleated           |                                                 1                        |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |    3        2  2  2  1  2  2     3  1  2  2     2     2  2  1     1      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +        +                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|             
                                           | 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis                        |                      2        3                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +                       +                                      +|             
      Gingival, Hyperplasia                |                                                                          |             
      Gingival, Inflammation               |          2                       1                                      2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1     1  1  1           1                           |             
      Acinus, Atrophy                      |    1              1     1              1              1  1           1   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                             1  1               |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                | 3     3                                               4     3  1        3|             
      Inflammation                         | 3     3                                            4  4     3           3|             
      Mineralization                       |                                                    2                     |             
      Ulcer                                | 3     3                                            4  4     2           2|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       3                                                                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |       2                                                     1            |             
      Mineralization                       |                               3                    4                    3|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +                                      +                           |             
      Inflammation                         |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                    4                     |             
      Pulmonary Artery, Pulmonary Vein,    |                                                                          |             
           Hypertrophy                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|             
                                           | 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Cardiomyopathy                       | 3  3  2  2  2  2  2  2  2  2  2  2  2  2           3  2  2  2  1  3  1  3|             
      Mineralization                       |                                                    2                     |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                               2               |             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hyperplasia                          |       1                    2           1              1  1              1|             
      Hypertrophy                          |    1              1                                4                     |             
      Vacuolization Cytoplasmic            | 2  1        1  1  1  2  1     1     1  1  1  1  1     2  1     2  1  1  3|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2              3  3                 1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3        2        1     1                    4     2  2           2|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1     3  3           2  2                 3     2      |             
      Cyst                                 |                                                                   1      |             
      Hyperplasia                          |          3                 3        1  2     2              3        1   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                      1                                                   |             
      C-Cell, Hyperplasia                  |    4                 1     2              2        4              1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|             
                                           | 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation                         |                                  1              2                        |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               4                                          |             
      Inflammation                         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1  2     3        1              1                        |             
      Hyperplasia                          |                                        1  4                 1        1   |             
      Inflammation                         |                1           1  3           2  1  1  1  2     1     2     2|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1  1     2        2              2                        |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                               2           1           2        1         |             
      Interstitial Cell, Hyperplasia       |          2           2        1           2  3        1        2  2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                  2                                       |             
      Myelofibrosis                        |                                                                          |             
      Erythroid Cell, Hyperplasia          |          1           1        2                 1                 2     2|             
      Myeloid Cell, Hyperplasia            |       2  3           2           2           4  2     3        4     4   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                             +           +        +              +  +|             
      Mediastinal, Ectasia                 |                                  1                                       |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                       1                  |             
      Mediastinal, Inflammation            |                                  2                                       |             
      Pancreatic, Ectasia                  |    2                             1                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|             
                                           | 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pancreatic, Hemorrhage               |                                  2                                       |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |    3                                                                    3|             
      Pancreatic, Inflammation             |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        2  1                             1|             
      Infiltration Cellular, Histiocyte    | 3  1  1  2  2  2  1  2  1  3     2  2  2  1  1  3  3  1  2  1  1  2  1  1|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 2                        |             
      Hematopoietic Cell Proliferation     |    1  1  2  1  1  1  1     1     2  2  1  1  1  1  1  1  1  1  1  2  1  2|             
      Hemorrhage                           |          1                                                               |             
      Hyperplasia, Lymphoid                |    3                 3           2     4        3                        |             
      Inflammation, Granulomatous          |    4                             3     3        4                        |             
      Pigmentation, Hemosiderin            | 1  1  1     1  1  1  1  1  1     1  1  1  1     1  1  1  1  1  1  1     1|             
      Lymphoid Follicle, Atrophy           |                                                             2            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  3  4  4  4  4  4     4  4  4  4     4  4  4  4  4  3  4  3  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                               1                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       2                                                                  |             
      Osteosclerosis                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
      Degeneration                         |                                              2                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|             
                                           | 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                    1                 1   |             
      Inflammation, Granulomatous          |                                                                4         |             
      Mineralization                       |                                                    4                    1|             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1  1     2  1  2     3                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  2  1  1  2  2  2  2  1  2  1  1  1  1  2  2  2  2  1  1  2     1  1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                2                 3     2              3           1      |             
      Thrombosis                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                             1            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1  1                                      1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ciliary Body, Inflammation           |                                                                          |             
      Iris, Fibrosis                       |          3                                                               |             
      Lens, Cataract                       |          4                                                               |             
      Retina, Degeneration                 |       1  4                                               1           2   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
      Infiltration Cellular, Lymphoid      |                      1              1  1     1  1                        |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                    +                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|             
                                           | 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    625 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                 2              2         |             
      Hyperplasia, Oncocytic               |                                                                          |             
      Nephropathy                          | 4  4  4  3  3  3  4  3  4  4  4  3  3  4  3  2  4  4  4  2  4  2  4  4  4|             
      Cortex, Mineralization               |                               3                    4                    2|             
      Medulla, Mineralization              | 1     1     1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pelvis, Inflammation                 |                                                                         1|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     | 2     2     1  1  1     1  2        1  1  1  1  1  2  1     2     2     1|             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Hyperplasia            | 1  4  1                       1                 2     1     1        1   |             
      Renal Tubule, Pigmentation           |                                              3                           |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Inflammation                         |       2                                                                 3|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                          2               |      1  2.0|
      Inflammation                         |                                                          2               |      1  2.0|
      Parasite Metazoan                    |                                     1                                    |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | 1  1                                X  1              1                  |      8  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                          1               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X     X  X  X  X  X     X  X     X        X  X  X        X         |     32     |
      Clear Cell Focus                     |    X        X        X                 X           X  X        X         |     18     |
      Degeneration, Cystic                 |       1           1  1  1        1     1                    3  1  1  1  3|     20  1.3|
      Eosinophilic Focus                   |             X                    X     X        X                        |     10     |
      Fatty Change, Diffuse                | 1                       1              2  2  1  1     1  2        1     2|     22  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic Active         |    2  2  1  2  1     2  1     2  2     2     2     2  2        2  1  2   |     35  1.9|
      Mixed Cell Focus                     |    X  X     X  X        X     X  X     X           X  X                  |     22     |
      Necrosis                             |                            2        1                    2  2           1|      9  1.7|
      Bile Duct, Hyperplasia               | 1  2  2  1  2  1  2  2  3  2  2  1  3  3  2     2  2  2  4  3  2  2  2  3|     48  2.1|
      Hepatocyte, Multinucleated           |                                                                          |      1  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Hypertrophy                      |    2  2     2  2  1     2     2  2     2     1  1  1           1  2  2   |     31  1.8|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                       +           +           +  +     +   |   8        |
      Inflammation                         |                                     2                                    |      1  2.0|
      Fat, Necrosis                        |             2                                   2           1  2     2   |      7  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                +                                            +            |   5        |
      Gingival, Hyperplasia                |                                                             4            |      1  4.0|
      Gingival, Inflammation               |                2                                            2            |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                   1      |      6  1.0|
      Acinus, Atrophy                      | 1  1           2  2  1           2     2  1     1  2  1  3  1        1  1|     22  1.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |    2              2  1                                   2               |     10  2.4|
      Inflammation                         |                   4                                      3               |      8  3.4|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                   4                                      3               |      8  3.1|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |       1                             1                                    |      3  1.7|
      Hyperplasia                          |                                                          2               |      1  2.0|
      Inflammation                         |                   2                                      2               |      4  1.8|
      Mineralization                       |                               1              2                           |      5  2.6|
      Ulcer                                |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                   1                                                      |      1  1.0|
      Mineralization                       |                                                                          |      1  4.0|
      Pulmonary Artery, Pulmonary Vein,    |                                                                          |            |
           Hypertrophy                     |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  3  1  3  3  3  3  2  1  2  3  1  2  1  1  2  3  2  1  2  3  2  2  1|     47  2.1|
      Mineralization                       |                1                                                         |      2  1.5|
      Atrium, Thrombosis                   |                                           1              2               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                  1                                       |      2  1.0|
      Hyperplasia                          |          1  1  1                                2  1                     |     11  1.2|
      Hypertrophy                          |                                                                          |      3  2.0|
      Vacuolization Cytoplasmic            | 1  1  2  1  1  2     2              2     1              2  1           1|     31  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      1  1        1  2     4                          3  2|     11  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |    1  1  1     1  4  3  2     1                                   1      |     19  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          3                    1        1                 3               |     11  2.2|
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia                          |                      3        1        1  1                             1|     12  1.8|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                       2                  |      2  1.5|
      C-Cell, Hyperplasia                  |    2  1                                                                  |      8  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                      +   |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                   1      |      1  1.0|
      Inflammation                         |       1                          1                                       |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Inflammation                         |             2                                                            |      1  2.0|
      Duct, Cyst                           |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   1                             1        1               |      8  1.4|
      Hyperplasia                          |                                                                          |      4  1.8|
      Inflammation                         | 2  1  1     1  2        1  2        1  1  1  2  2        4        1     1|     26  1.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   2                             1        1               |      8  1.5|
      Inflammation                         |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Degeneration    |          2     4                                                         |      6  2.0|
      Interstitial Cell, Hyperplasia       |          1                    2           2  2           2  4            |     14  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Myelofibrosis                        |                         2           2                                    |      2  2.0|
      Erythroid Cell, Hyperplasia          |    1  1     2                                   1                        |     10  1.4|
      Myeloid Cell, Hyperplasia            |       3           3     1  3     2  4     3     1        3  3           4|     20  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +     +  +              +              +  +        +  +|  16        |
      Mediastinal, Ectasia                 |    1  2                                                              2   |      4  1.5|
      Mediastinal, Hemorrhage              |                                                                      2   |      1  2.0|
      Mediastinal, Hyperplasia             |    2                                                                     |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                         2                                                |      2  1.5|
      Mediastinal, Inflammation            |                                                                          |      1  2.0|
      Pancreatic, Ectasia                  |                                                                          |      2  1.5|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      2  3.0|
      Pancreatic, Inflammation             |                            2                             2               |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                      2                 2                                 |      5  1.6|
      Infiltration Cellular, Histiocyte    | 2  2  1  1  1  2  2  2  2  1  2  2  1  1  1  2  2  1  3  1  1  1  2  2   |     48  1.6|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |    3        2                                                            |      3  2.3|
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  2  1  1  2  1     1  1|     45  1.2|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                1                 3                          4     1      |      9  2.7|
      Inflammation, Granulomatous          |       4              2           3                                       |      7  3.3|
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1     1  1  1  1|     44  1.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 4  2  3  3  4  4  4  4  4  4  3  3     4  4  4  4  4  4  4  4  4  4  4  4|     47  3.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
      Osteosclerosis                       |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                            2                                            3|      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                               1  1  2                                    |      5  1.2|
      Inflammation, Granulomatous          |       2        2  1                                                  1   |      5  2.0|
      Mineralization                       |                                                                          |      2  2.5|
      Thrombosis                           |                                     3                                    |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                               3  1  2                 1     1  2        1|     13  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
           Histiocyte                      | 1  1  1  2  1  1  2  2  2  1  2  2  1  2  2  2  2  1  2  1  1  2  1  1  2|     49  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                2                 1                 1                     |      8  1.9|
      Thrombosis                           |                                                          3               |      1  3.0|
      Olfactory Epithelium, Metaplasia     |                            1                                             |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      1     1  1              1                       1   |      8  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ciliary Body, Inflammation           |                                                                   1      |      1  1.0|
      Iris, Fibrosis                       |                                                                          |      1  3.0|
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                         1|      5  1.8|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphoid      |    1           1           1                                      1      |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |          +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                 1        1               |      4  1.5|
      Hyperplasia, Oncocytic               |          2                                                               |      1  2.0|
      Nephropathy                          | 2  4  4  4  3  4  4  4  4  4  4  3  4  4  2  1  3  2  1  2  3  3  4  4  1|     50  3.3|
      Cortex, Mineralization               |                                  1                                       |      4  2.5|
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  1  1  1  2  2  1  1  1  1  2  1  1  2  1  1  1  1|     47  1.1|
      Pelvis, Inflammation                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9|            |
                                           | 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    625 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |    2  2  1  2  1        2     2  1  1  2                          2  2   |     29  1.5|
      Renal Tubule, Cyst                   |                                                                      X   |      1     |
      Renal Tubule, Hyperplasia            |    1  1  1        2  2        2  1     2        1              1  2  1   |     20  1.5|
      Renal Tubule, Pigmentation           |       3                                                                  |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                X                                                         |      1     |
      Inflammation                         |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|             
                             DAY ON TEST   | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|             
                                           | 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    1                                      1  1                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         4|             
      Inflammation                         |                                     3                       1           4|             
      Mineralization                       |                                     2                                   2|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X        X  X  X  X        X  X     X  X        X           X           X|             
      Degeneration, Cystic                 | 1     1                 1              1              1        1         |             
      Eosinophilic Focus                   |                            X                                      X      |             
      Fatty Change, Diffuse                | 2  1  2  1  1  1                    2              2                     |             
      Hematopoietic Cell Proliferation     |                                  1                                       |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              | X                                                                        |             
      Inflammation, Chronic Active         | 2  2  2     2  2  2     1  1  2  2  3  2     1  2  2     1  2  1        2|             
      Inflammation, Granulomatous          |          2                                3                              |             
      Mineralization                       |                                                                      1   |             
      Mixed Cell Focus                     |          X  X                                               X            |             
      Necrosis                             |                                  2     2              2           2      |             
      Bile Duct, Hyperplasia               | 1  1  1  2  1  1  1  2  1  1  1  1  2  3  1  1  1  2  2  1  1  1  2  1  1|             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      | 2  1  2     1  1  2     1                 2  2  1                       1|             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
      Vein, Inflammation                   |                                                    2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|             
                             DAY ON TEST   | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|             
                                           | 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                         +              +               |             
      Inflammation                         |                                                                          |             
      Fat, Necrosis                        | 2                                         2              2               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +                 +                             +               |             
      Gingival, Inflammation               |          1                 1                             2               |             
      Pharyngeal, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       1                  |             
      Inflammation                         |                1              1                                1  1      |             
      Metaplasia, Hepatocyte               |                                                          1               |             
      Acinus, Atrophy                      |    2              1                                            1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       2           2     3     3              3  3        3     3     3   |             
      Inflammation                         |                         2     4              2  2        3     3     4   |             
      Mineralization                       |          2     3                                                         |             
      Ulcer                                |                         3     4                          1     3     4   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                2         |             
      Inflammation                         |    1                                                                     |             
      Mineralization                       | 2  2     4  3  4                    3        2              4           3|             
      Ulcer                                |                   1                                      3               |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +                                                     +                  |             
      Inflammation                         | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 3  2     3  4  3                    4                       2     1     4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|             
                             DAY ON TEST   | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|             
                                           | 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2  3  3  1  3  2  1  2  2  1  1  3  2  2  1  2  3  1  1  2  2  2  3  3|             
      Mineralization                       | 2        2     4                    2                                   2|             
      Atrium, Thrombosis                   |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                                        |             
      Hyperplasia                          |                         1                 2                          1   |             
      Hypertrophy                          |                                                          1               |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 1  1  2           1  1        2           1           2  1     2     2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1           1                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2  2  3  3  2  1     1           2  2  1  3  1  3     2  2  3     1  4|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                            2                  |             
      Cyst                                 |             1        1                                                   |             
      Hyperplasia                          |       1  4                          2     1                              |             
      Inflammation                         |                                                             1            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                     1                                    |             
      C-Cell, Hyperplasia                  |                                           1                              |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|             
                             DAY ON TEST   | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|             
                                           | 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      | 1                                                                        |             
      Inflammation                         |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              1              1            |             
      Inflammation                         | 1     2  3     1        1     1  1  3  1        1     1        2     2  2|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              1              1            |             
      Inflammation                         |                                                                          |             
      Mineralization                       |          1     3                                            3            |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                         1|             
      Germinal Epithelium, Degeneration    |                                  4                    4        2         |             
      Interstitial Cell, Hyperplasia       |    3                 2     1     2           1     2  2     2  2     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                           2                              |             
      Myelofibrosis                        |    1                    1                                                |             
      Erythroid Cell, Hyperplasia          | 1        2                 2     1     1  2                              |             
      Myeloid Cell, Hyperplasia            |                      4     3     3     2  1                              |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +        +           +     +  +  +     +  +                    +     +|             
      Deep Cervical, Ectasia               |                                                                          |             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Plasma Cell                     |                               2                                          |             
      Mediastinal, Ectasia                 |             1                                                            |             
      Mediastinal, Hemorrhage              |    2                                2                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|             
                             DAY ON TEST   | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|             
                                           | 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hyperplasia             |                                  2                                2      |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                     2        2                           |             
      Pancreatic, Ectasia                  |                               1           3                              |             
      Pancreatic, Hemorrhage               |                                     1                                    |             
      Pancreatic, Inflammation             |                                           3                              |             
      Renal, Ectasia                       |                         2                                                |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                         3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2  1  2  3     2                                                |             
      Ectasia                              |    2                                                                     |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  2  1  1  1  1  2  1  1  3  1  2  1  1  1     1  1  1  1  2  3|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1     2  1  1  2  1  1  1  1     1     1     1|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |             1  3                 2                                       |             
      Inflammation, Granulomatous          |                                           4                              |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1     1  1  1     2  1  1  1  1  1  1  1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |          3                                                        2      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  2  4  4  3  4  3  4  3  4  4     4  4  4     4  4  4  4  4  4|             
      Ectopic Parathyroid Gland            |                   1                                            1     1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|             
                             DAY ON TEST   | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|             
                                           | 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1                                                           2            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 2  1     2     1                                               1         |             
      Inflammation, Granulomatous          |                      3                                                   |             
      Metaplasia, Squamous                 |                                                             1            |             
      Mineralization                       | 2  3     2  3  3                    2                       4           3|             
      Alveolar Epithelium, Hyperplasia     | 2  1        1                 2           1                             1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1  2  2  2  1  2  1  2  2  2  1  2  2  2  1  2  2  1  2  2  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2                 2                          2                       1|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Inflammation       |                                                                         3|             
      Cornea, Inflammation                 |                                                 1                        |             
      Iris, Inflammation                   | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphoid      |    1                                         1                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|             
                             DAY ON TEST   | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|             
                                           | 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                           4                              |             
      Nephropathy                          | 4  4  4  4  4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Artery, Inflammation                 |                                                    2                     |             
      Cortex, Mineralization               | 3  2     4  2  4                    4        1              4           4|             
      Medulla, Mineralization              | 1  1  1  2  2  2  1  1  1  2  1  1  2  1  1  1  1  1  1  1  2  1  1  1  2|             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Pelvis, Inflammation                 |          2                                                               |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     | 2  2  2     2  2     1  1     1     2  1  1  1     3     1  2  1     1  1|             
      Renal Tubule, Cyst                   |       X        X  X           X           X                             X|             
      Renal Tubule, Hyperplasia            |    1     1     1  1     2     1     1        2  1           1  1     1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2                                                               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          1           1                                                   |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  4.0|
      Inflammation                         |                   4                                                      |      4  3.0|
      Mineralization                       |                                                                          |      2  2.0|
      Ulcer                                |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |             X        X     X  X                 X  X     X               |     19     |
      Degeneration, Cystic                 | 1                    1  3        1     1  1        2              1  1   |     15  1.2|
      Eosinophilic Focus                   |                X     X     X     X  X  X                 X               |      9     |
      Fatty Change, Diffuse                |             1     2  2                             2        1        3  3|     15  1.7|
      Hematopoietic Cell Proliferation     |                1                    1  1                                 |      4  1.0|
      Hepatodiaphragmatic Nodule           |                                                                   X      |      1     |
      Infarct                              |                                                                          |      1     |
      Inflammation, Chronic Active         | 1     2  2  2  2  3  2     2     1  3           1        2  2     2      |     33  1.8|
      Inflammation, Granulomatous          |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  1.0|
      Mixed Cell Focus                     |          X                                                               |      4     |
      Necrosis                             | 2  1                 1        2  1        3  1        1        2        2|     14  1.7|
      Bile Duct, Hyperplasia               | 1  3  2  1  2  1  2  1  3  2  2  1  2  2  1  2  1  3  2  1  2  2  1  2  2|     50  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      |       1     2  1     1              3                       1  2     2   |     19  1.5|
      Hepatocyte, Centrilobular, Necrosis  |                               1                                          |      1  1.0|
      Vein, Inflammation                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   4        |
      Inflammation                         |                                                       1                  |      1  1.0|
      Fat, Necrosis                        |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +                 +                                         +  +         |   7        |
      Gingival, Inflammation               | 1                                                              1         |      5  1.2|
      Pharyngeal, Inflammation             |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             1        1                                                   |      3  1.0|
      Inflammation                         |    1  1              1              1                 1                  |      9  1.0|
      Metaplasia, Hepatocyte               |                                                                          |      1  1.0|
      Acinus, Atrophy                      |    1        1        1     2  1           1                          1   |     10  1.2|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                | 2     3                    3  3  3              3              1        1|     17  2.6|
      Inflammation                         |       2                    2  3  2              2                        |     12  2.6|
      Mineralization                       |                                                          3               |      3  2.7|
      Ulcer                                | 1                             4  4                                       |      8  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                               1                                   4      |      3  2.3|
      Inflammation                         |       2  1              2        3           2     1                     |      7  1.7|
      Mineralization                       |             2     3        3     1                       3  1            |     15  2.7|
      Ulcer                                | 1                                4                                       |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                              +                           |   3        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                   4                                      4               |     11  3.1|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  1  1  3  2  2  2     1  2  1  3  1  2  1  2  2  2  3  2  1  1  2  1|     49  1.9|
      Mineralization                       |                                                          2               |      6  2.3|
      Atrium, Thrombosis                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hyperplasia                          |          1                                                               |      4  1.3|
      Hypertrophy                          |          1                                                  1            |      3  1.0|
      Necrosis                             |                                                                1         |      1  1.0|
      Vacuolization Cytoplasmic            | 1              1  2     1  2  2  3  1  1           1  2  1  1     1  1  2|     27  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            3     1                          3            |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    1  1  1  3     4  2     3  4  2              1  1     3  2            |     32  2.2|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   1                                                      |      3  1.7|
      Cyst                                 |                1        1                                               1|      5  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          |          1  2     2  2     2  1  4        1        1                     |     13  1.8|
      Inflammation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |             1                                      2           1  2      |      5  1.4|
      Follicular Cell, Hyperplasia         |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                      2   |      2  1.5|
      Inflammation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                     2                                    |      1  2.0|
      Inflammation                         |                                     2                                    |      1  2.0|
      Duct, Cyst                           |                            4                                             |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1           2                                                   |      4  1.3|
      Inflammation                         | 3        1              1  1     2  1     2        1  1  2     1  3      |     26  1.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |          1           2                                                   |      4  1.3|
      Inflammation                         | 2                                                                        |      1  2.0|
      Mineralization                       |                                                          4               |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
      Germinal Epithelium, Degeneration    |                1        1  4  4                                          |      7  2.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 1  3        2  2  2     2     1  1  4  2     1                 1         |     22  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                     2                                    |      2  2.0|
      Myelofibrosis                        |                                                                          |      2  1.0|
      Erythroid Cell, Hyperplasia          |    1           1                    4  2                                 |     10  1.7|
      Myeloid Cell, Hyperplasia            |    2           2        3              2  2  4     3           4        3|     14  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                 +                       +     +  +     +  +  +     +|  19        |
      Deep Cervical, Ectasia               |                                                                   2      |      1  2.0|
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Plasma Cell                     |                                                                   1      |      2  1.5|
      Mediastinal, Ectasia                 |                      1                                      1            |      3  1.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      2  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                             2            |      3  2.0|
      Pancreatic, Ectasia                  |                                                                          |      2  2.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  1.0|
      Pancreatic, Inflammation             |                                                                          |      1  3.0|
      Renal, Ectasia                       |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      2                                                   |      6  2.0|
      Ectasia                              |       2                       1                 2                        |      4  1.8|
      Infiltration Cellular, Histiocyte    | 1  1  2  1  3  1  3  1  1  3  1  1  3  2     1  1  1     1  1  1  3  2   |     46  1.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Fibrosis                             |                                                             3            |      1  3.0|
      Hematopoietic Cell Proliferation     | 2  1  1  1  1  2  1  1  1  1     1  2  2     1     1  1        1  1  1  2|     41  1.2|
      Hemorrhage                           |                                                       3                  |      1  3.0|
      Hyperplasia, Lymphoid                |                      2                                                   |      4  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Necrosis                             |                                                                2         |      1  2.0|
      Pigmentation, Hemosiderin            | 1  1  1  1  1  1  1  1     1  1  1        1  1  1  1     1  1     1  1  1|     43  1.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 4  3  4  3  4  4  4  4     4     4  3  4  4  4  4  4  4  4  4  4  3  3  4|     46  3.8|
      Ectopic Parathyroid Gland            |                            1                                             |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                   2        2                                             |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                         3                 2  2        2                  |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                          1              1|      7  1.3|
      Inflammation, Granulomatous          |                                     1                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Mineralization                       |                   2                                      3               |     10  2.7|
      Alveolar Epithelium, Hyperplasia     |                                        1                                 |      7  1.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  2  2  2  2  1  2  2  2  2  2  1  2  2  1  2  1  2  1  2  2  3  2  2  1|     50  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                 2     3  2     2         |      9  1.9|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                          2     3         |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Anterior Chamber, Inflammation       |                                                                          |      1  3.0|
      Cornea, Inflammation                 |                                                                          |      1  1.0|
      Iris, Inflammation                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                                                               |      1  1.0|
      Infiltration Cellular, Lymphoid      |                                                                1         |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                              1                           |      2  2.5|
      Nephropathy                          | 3  4  4  4  4  2  4  4  4  4  4  4  2  4  2  4  4  4  4  4  4  2  4  4  4|     50  3.8|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Cortex, Mineralization               |             1     3        2                             4  1            |     14  2.8|
      Medulla, Mineralization              | 1  1  1  1  1  1  2  1  1  2  1  1  1  1  1  1  1  1  1  2  1     1  1  1|     49  1.2|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                 1                        |      1  1.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 07/21/03    
Route: DOSED FEED                                                                                                 Time: 15:26:04    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5|            |
                             DAY ON TEST   | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4|            |
                                           | 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |    2  2  1  2     2  2     2  2  3     2     2     2  1  2  2        2   |     34  1.7|
      Renal Tubule, Cyst                   |       X                                                  X           X   |      9     |
      Renal Tubule, Hyperplasia            | 1                 2  2     2  1  3     2     1           1           1  1|     23  1.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1                                                                     |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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