National Toxicology Program

National Toxicology Program
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TDMS Study 88138-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 07/21/03       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 15:27:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 07/21/03       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 15:27:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                      BENZOPHENONE                                                                                
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Blood Vessel                           Mineralization                                                                               
Bone                                   Fibrous Osteodystrophy                                                                       
Bone Marrow                            Inflammation Granulomatous                                                                   
                                       Myelofibrosis                                                                                
Bone Marrow: Erythroid Cell            Hyperplasia                                                                                  
Bone Marrow: Myeloid Cell              Hyperplasia                                                                                  
Brain                                  Necrosis                                                                                     
Epididymis                             Granuloma Sperm                                                                              
Eye: Retina                            Degeneration                                                                                 
Heart                                  Cardiomyopathy                                                                               
                                       Mineralization                                                                               
Intestine Large, Cecum                 Inflammation                                                                                 
                                       Mineralization                                                                               
Kidney                                 Nephropathy                                                                                  
Kidney: Cortex                         Mineralization                                                                               
Kidney: Medulla                        Mineralization                                                                               
Kidney: Pelvis                         Inflammation                                                                                 
Kidney: Pelvis, Transitional Epithelium                                                                                             
                                       Hyperplasia                                                                                  
Kidney: Renal Tubule                   Cyst                                                                                         
                                       Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Inflammation Chronic                                                                         
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte, Centrilobular       Hypertrophy                                                                                  
Lung                                   Inflammation Acute                                                                           
                                       Mineralization                                                                               
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Lymph Node, Mesenteric                 Atrophy                                                                                      
                                       Ectasia                                                                                      
                                       Infiltration Cellular Histiocyte                                                             
Lymph Node: Mediastinal                Ectasia                                                                                      
                                       Hyperplasia                                                                                  
                                       Infiltration Cellular Plasma Cell                                                            
Lymph Node: Pancreatic                 Ectasia                                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 07/21/03       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 15:27:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
                                       Inflammation                                                                                 
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Inflammation                                                                                 
Pancreas                               Cyst                                                                                         
                                       Inflammation                                                                                 
Pancreas: Acinus                       Atrophy                                                                                      
Parathyroid Gland                      Hyperplasia                                                                                  
Pituitary Gland                        Angiectasis                                                                                  
                                       Cyst                                                                                         
                                       Hyperplasia                                                                                  
Prostate                               Atrophy                                                                                      
                                       Inflammation                                                                                 
Seminal Vesicle                        Atrophy                                                                                      
                                       Mineralization                                                                               
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia Lymphoid                                                                         
                                       Inflammation Granulomatous                                                                   
                                       Pigmentation Hemosiderin                                                                     
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Mineralization                                                                               
                                       Ulcer                                                                                        
Stomach, Glandular                     Inflammation                                                                                 
                                       Mineralization                                                                               
                                       Ulcer                                                                                        
Testes: Germinal Epithelium            Degeneration                                                                                 
Testes: Interstitial Cell              Hyperplasia                                                                                  
Thymus                                 Atrophy                                                                                      
                                       Ectopic Parathyroid Gland                                                                    
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Trachea                                Inflammation                                                                                 
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
Adrenal Medulla                        Necrosis                                                                                     
Bone                                   Fibrous Osteodystrophy                                                                       
Bone Marrow                            Myelofibrosis                                                                                
Bone Marrow: Erythroid Cell            Hyperplasia                                                                                  
Bone Marrow: Myeloid Cell              Hyperplasia                                                                                  
Clitoral Gland                         Hyperplasia                                                                                  
Harderian Gland                        Infiltration Cellular Lymphoid                                                               
Kidney: Medulla                        Mineralization                                                                               
Liver                                  Basophilic Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Inflammation Chronic                                                                         
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte, Centrilobular       Hypertrophy                                                                                  
Liver: Oval Cell                       Hyperplasia                                                                                  
Lung                                   Inflammation Granulomatous                                                                   
Lymph Node: Deep Cervical              Infiltration Cellular Histiocyte                                                             
                                       Infiltration Cellular Plasma Cell                                                            
Lymph Node: Mediastinal                Hemorrhage                                                                                   
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 07/21/03       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 15:27:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
Mammary Gland                          Galactocele                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
Pancreas                               Inflammation                                                                                 
Pancreas: Acinus                       Atrophy                                                                                      
Pituitary Gland                        Angiectasis                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
Spleen: Lymphoid Follicle              Atrophy                                                                                      
Stomach, Glandular                     Inflammation                                                                                 
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                       BENZOPHENONE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/49 (8%)    2/50 (4%)    1/50 (2%)   |42/50 (84%)  36/50 (72%)  18/50 (36%)  24/50 (48%)  | 
|POLY-3 RATE (b)    |     4/42.08      4/41.92      2/44.46      1/32.16     |42/47.20     36/48.60     18/47.66     24/47.36     | 
|POLY-3 PERCENT (g) |     9.5%         9.5%         4.5%         3.1%        |89.0%        74.1%        37.8%        50.7%        | 
|TERMINAL (d)       |     4/22 (18%)   2/27 (7%)    1/31 (3%)    0/2 (0%)    |31/32 (97%)  30/38 (79%)  16/37 (43%)  19/34 (56%)  | 
|FIRST INCIDENCE    |     729 (T)      373          687          691         |528          613          662          528          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.398N     P=0.548N     P=0.199N     P=0.546     |P<0.001N**   P=0.014N*    P<0.001N**   P<0.001N**   | 
|POLY 3             |     P=0.139N     P=0.642      P=0.311N     P=0.270N    |P<0.001N**   P=0.046N*    P<0.001N**   P<0.001N**   | 
|POLY 1.5           |     P=0.118N     P=0.635      P=0.324N     P=0.222N    |P<0.001N**   P=0.055N     P<0.001N**   P<0.001N**   | 
|POLY 6             |     P=0.172N     P=0.632N     P=0.290N     P=0.366N    |P<0.001N**   P=0.049N*    P<0.001N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.123N     P=0.631      P=0.251N     P=0.719     |P<0.001N**   P=0.026N*    P<0.001N**   P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.094N     P=0.631      P=0.339N     P=0.181N    |P<0.001N**   P=0.114N     P<0.001N**   P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.242N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.76      0/40.97      0/44.30      0/32.01     |3/44.94      2/47.49      2/47.41      0/45.76      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |6.7%         4.2%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    2/38 (5%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          ---          ---          ---         |430          729 (T)      679          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.508N     P=0.504N     P=0.504N    |P=0.083N     P=0.443N     P=0.458N     P=0.121N     | 
|POLY 3             |     P=0.258N     P=0.509N     P=0.493N     P=0.557N    |P=0.086N     P=0.475N     P=0.476N     P=0.115N     | 
|POLY 1.5           |     P=0.284N     P=0.508N     P=0.497N     P=0.529N    |P=0.085N     P=0.482N     P=0.483N     P=0.116N     | 
|POLY 6             |     P=0.229N     P=0.506N     P=0.486N     P=0.602N    |P=0.088N     P=0.470N     P=0.471N     P=0.117N     | 
|LOGISTIC REGRESSION|     P=0.293N     P=0.367N     P=0.599N     P=0.511N    |P=0.104N     P=0.586N     P=0.602N     P=0.156N     | 
|COCH-ARM / FISHERS |     P=0.305N     P=0.505N     P=0.500N     P=0.500N    |P=0.086N     P=0.500N     P=0.500N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.178N     (e)          (e)          (e)         |P=0.074N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   0/49 (0%)    2/50 (4%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/43.16      0/40.97      2/44.46      0/32.01     |3/44.12      1/47.49      2/47.30      2/45.76      | 
|POLY-3 PERCENT (g) |     11.6%        0.0%         4.5%         0.0%        |6.8%         2.1%         4.2%         4.4%         | 
|TERMINAL (d)       |     2/22 (9%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |3/32 (9%)    1/38 (3%)    0/37 (0%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     549          ---          687          ---         |729 (T)      729 (T)      709          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076N     P=0.032N*    P=0.151N     P=0.227N    |P=0.495N     P=0.245N     P=0.439N     P=0.472N     | 
|POLY 3             |     P=0.037N*    P=0.034N*    P=0.203N     P=0.065N    |P=0.501N     P=0.279N     P=0.468N     P=0.483N     | 
|POLY 1.5           |     P=0.032N*    P=0.034N*    P=0.210N     P=0.045N*   |P=0.499N     P=0.287N     P=0.478N     P=0.487N     | 
|POLY 6             |     P=0.045N*    P=0.034N*    P=0.192N     P=0.116N    |P=0.505N     P=0.274N     P=0.462N     P=0.485N     | 
|LOGISTIC REGRESSION|     P=0.028N*    P=0.033N*    P=0.225N     P=0.033N*   |P=0.511N     P=0.245N     P=0.463N     P=0.472N     | 
|COCH-ARM / FISHERS |     P=0.029N*    P=0.030N*    P=0.218N     P=0.028N*   |P=0.500N     P=0.309N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.012N*    (e)          (e)          (e)         |P=0.364N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/49 (8%)    11/50 (22%)  4/50 (8%)   |6/50 (12%)   10/50 (20%)  6/50 (12%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/42.26      4/41.44      11/44.91     4/32.81     |6/44.14      10/48.39     6/47.78      6/45.93      | 
|POLY-3 PERCENT (g) |     2.4%         9.7%         24.5%        12.2%       |13.6%        20.7%        12.6%        13.1%        | 
|TERMINAL (d)       |     0/22 (0%)    3/27 (11%)   8/31 (26%)   1/2 (50%)   |5/32 (16%)   6/38 (16%)   4/37 (11%)   5/34 (15%)   | 
|FIRST INCIDENCE    |     681          590          624          624         |725          633          644          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.225      P=0.013 *    P=0.010 *   |P=0.381N     P=0.319      P=0.518N     P=0.581N     | 
|POLY 3             |     P=0.043 *    P=0.172      P=0.003 **   P=0.111     |P=0.367N     P=0.267      P=0.564N     P=0.593N     | 
|POLY 1.5           |     P=0.088      P=0.170      P=0.002 **   P=0.141     |P=0.371N     P=0.246      P=0.582N     P=0.598N     | 
|POLY 6             |     P=0.011 *    P=0.178      P=0.003 **   P=0.072     |P=0.371N     P=0.289      P=0.548N     P=0.594N     | 
|LOGISTIC REGRESSION|     P=0.030 *    P=0.171      P=0.004 **   P=0.075     |P=0.378N     P=0.244      P=0.574N     P=0.618N     | 
|COCH-ARM / FISHERS |     P=0.173      P=0.175      P=0.002 **   P=0.181     |P=0.391N     P=0.207      P=0.620N     P=0.620N     | 
|ORDER RESTRICTED   |     P=0.021 *    (e)          (e)          (e)         |P=0.442N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   2/49 (4%)    3/50 (6%)    3/50 (6%)   |7/50 (14%)   5/50 (10%)   5/50 (10%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     8/42.68      2/41.05      3/44.31      3/32.45     |7/44.47      5/47.58      5/47.22      8/46.80      | 
|POLY-3 PERCENT (g) |     18.7%        4.9%         6.8%         9.3%        |15.7%        10.5%        10.6%        17.1%        | 
|TERMINAL (d)       |     4/22 (18%)   1/27 (4%)    2/31 (7%)    1/2 (50%)   |5/32 (16%)   3/38 (8%)    5/37 (14%)   5/34 (15%)   | 
|FIRST INCIDENCE    |     676          710          726          662         |637          710          729 (T)      480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      P=0.032N*    P=0.042N*    P=0.266     |P=0.381      P=0.283N     P=0.291N     P=0.540      | 
|POLY 3             |     P=0.142N     P=0.050N     P=0.085N     P=0.207N    |P=0.391      P=0.333N     P=0.338N     P=0.543      | 
|POLY 1.5           |     P=0.126N     P=0.051N     P=0.092N     P=0.146N    |P=0.388      P=0.346N     P=0.349N     P=0.532      | 
|POLY 6             |     P=0.158N     P=0.047N*    P=0.076N     P=0.345N    |P=0.388      P=0.324N     P=0.333N     P=0.544      | 
|LOGISTIC REGRESSION|     P=0.324N     P=0.046N*    P=0.067N     P=0.562N    |P=0.381      P=0.322N     P=0.323N     P=0.509      | 
|COCH-ARM / FISHERS |     P=0.107N     P=0.049N*    P=0.100N     P=0.100N    |P=0.372      P=0.380N     P=0.380N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.074N     (e)          (e)          (e)         |P=0.396      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/49 (8%)    0/50 (0%)    1/50 (2%)   |5/50 (10%)   7/50 (14%)   5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/42.64      4/42.02      0/44.30      1/32.71     |5/45.17      7/47.99      5/47.30      2/45.92      | 
|POLY-3 PERCENT (g) |     2.4%         9.5%         0.0%         3.1%        |11.1%        14.6%        10.6%        4.4%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    3/38 (8%)    4/37 (11%)   1/34 (3%)    | 
|FIRST INCIDENCE    |     553          624          ---          487         |430          653          709          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.511N     P=0.181      P=0.504N     P=0.747     |P=0.122N     P=0.475      P=0.557N     P=0.214N     | 
|POLY 3             |     P=0.381N     P=0.173      P=0.492N     P=0.698     |P=0.115N     P=0.423      P=0.601N     P=0.209N     | 
|POLY 1.5           |     P=0.362N     P=0.171      P=0.496N     P=0.730     |P=0.114N     P=0.410      P=0.608N     P=0.210N     | 
|POLY 6             |     P=0.400N     P=0.183      P=0.485N     P=0.638     |P=0.119N     P=0.433      P=0.598N     P=0.213N     | 
|LOGISTIC REGRESSION|     P=0.245N     P=0.191      P=0.551N     P=0.715N    |P=0.124N     P=0.324      P=0.603      P=0.246N     | 
|COCH-ARM / FISHERS |     P=0.335N     P=0.175      P=0.500N     P=0.753N    |P=0.118N     P=0.380      P=0.630N     P=0.218N     | 
|ORDER RESTRICTED   |     P=0.250N     (e)          (e)          (e)         |P=0.143N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  27/49 (55%)  31/50 (62%)  27/50 (54%) |14/50 (28%)  16/50 (32%)  15/50 (30%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     27/47.51     27/46.76     31/48.48     27/40.73    |14/44.91     16/48.30     15/48.78     20/47.93     | 
|POLY-3 PERCENT (g) |     56.8%        57.8%        63.9%        66.3%       |31.2%        33.1%        30.8%        41.7%        | 
|TERMINAL (d)       |     8/22 (36%)   13/27 (48%)  18/31 (58%)  1/2 (50%)   |10/32 (31%)  10/38 (26%)  8/37 (22%)   11/34 (32%)  | 
|FIRST INCIDENCE    |     425          344          494          529         |528          609          528          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.407N     P=0.408N     P<0.001 **  |P=0.153      P=0.561N     P=0.519N     P=0.213      | 
|POLY 3             |     P=0.170      P=0.548      P=0.306      P=0.235     |P=0.163      P=0.508      P=0.571N     P=0.200      | 
|POLY 1.5           |     P=0.303      P=0.544      P=0.290      P=0.387     |P=0.151      P=0.479      P=0.571      P=0.181      | 
|POLY 6             |     P=0.062      P=0.551      P=0.330      P=0.080     |P=0.175      P=0.533      P=0.541N     P=0.219      | 
|LOGISTIC REGRESSION|     P=0.435N     P=0.556      P=0.221      P=0.582N    |P=0.126      P=0.492      P=0.526      P=0.162      | 
|COCH-ARM / FISHERS |     P=0.516      P=0.537      P=0.272      P=0.579N    |P=0.125      P=0.414      P=0.500      P=0.146      | 
|ORDER RESTRICTED   |     P=0.286      (e)          (e)          (e)         |P=0.229      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   8/49 (16%)   11/50 (22%)  5/50 (10%)  |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/43.90      8/41.16      11/45.30     5/33.05     |0/44.12      1/47.49      2/47.33      0/45.76      | 
|POLY-3 PERCENT (g) |     13.7%        19.4%        24.3%        15.1%       |0.0%         2.1%         4.2%         0.0%         | 
|TERMINAL (d)       |     2/22 (9%)    6/27 (22%)   5/31 (16%)   0/2 (0%)    |0/32 (0%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     425          702          543          604         |---          729 (T)      701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.047 *    P=0.485      P=0.308      P=0.174     |P=0.618N     P=0.534      P=0.264      (e)          | 
|POLY 3             |     P=0.400      P=0.336      P=0.156      P=0.558     |P=0.605N     P=0.515      P=0.253      (e)          | 
|POLY 1.5           |     P=0.537      P=0.346      P=0.148      P=0.603N    |P=0.607N     P=0.510      P=0.248      (e)          | 
|POLY 6             |     P=0.226      P=0.335      P=0.173      P=0.403     |P=0.608N     P=0.518      P=0.257      (e)          | 
|LOGISTIC REGRESSION|     P=0.502      P=0.368      P=0.129      P=0.481N    |P=0.615N     P=0.534      P=0.251      (e)          | 
|COCH-ARM / FISHERS |     P=0.415N     P=0.371      P=0.143      P=0.500N    |P=0.616N     P=0.500      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.371      (e)          (e)          (e)         |P=0.337N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/40.97      0/44.30      0/32.01     |2/44.35      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |673          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.221N     P=0.227N     P=0.241N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.222N     P=0.224N     P=0.230N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.117N     P=0.227N     P=0.227N     P=0.231N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.220N     P=0.222N     P=0.232N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.117N     P=0.236N     P=0.236N     P=0.235N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel                                                                                                                     | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    11/50 (22%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.08      1/41.93      1/44.31      11/36.43    |0/44.12      0/47.49      0/47.22      1/45.78      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.3%         30.2%       |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          624          726          488         |---          ---          ---          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.486      P=0.566      P<0.001 **  |P=0.193      (e)          (e)          P=0.512      | 
|POLY 3             |     P<0.001 **   P=0.499      P=0.510      P<0.001 **  |P=0.200      (e)          (e)          P=0.507      | 
|POLY 1.5           |     P<0.001 **   P=0.498      P=0.505      P<0.001 **  |P=0.200      (e)          (e)          P=0.506      | 
|POLY 6             |     P<0.001 **   P=0.504      P=0.519      P<0.001 **  |P=0.198      (e)          (e)          P=0.507      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.522      P=0.551      P=0.003 **  |P=0.193      (e)          (e)          P=0.501      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.500      P<0.001 **  |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.127      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Fibrous Osteodystrophy                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      1/44.45      4/33.05     |0/44.12      0/47.49      0/47.22      2/45.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         12.1%       |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          691          593         |---          ---          ---          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.546      P=0.008 **  |P=0.046 *    (e)          (e)          P=0.254      | 
|POLY 3             |     P=0.003 **   (e)          P=0.511      P=0.035 *   |P=0.046 *    (e)          (e)          P=0.246      | 
|POLY 1.5           |     P=0.004 **   (e)          P=0.506      P=0.046 *   |P=0.046 *    (e)          (e)          P=0.244      | 
|POLY 6             |     P=0.003 **   (e)          P=0.520      P=0.022 *   |P=0.045 *    (e)          (e)          P=0.246      | 
|LOGISTIC REGRESSION|     P=0.005 **   (e)          P=0.502      P=0.041 *   |P=0.046 *    (e)          (e)          P=0.241      | 
|COCH-ARM / FISHERS |     P=0.006 **   (e)          P=0.500      P=0.059     |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.002 **   (e)          (e)          (e)         |P=0.033 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/40.97      1/44.30      2/32.71     |1/44.12      1/47.49      1/47.22      1/46.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         6.1%        |2.3%         2.1%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      529         |729 (T)      729 (T)      729 (T)      480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.011 *    (e)          P=0.568      P=0.119     |P=0.629N     P=0.723N     P=0.729N     P=0.747N     | 
|POLY 3             |     P=0.048 *    (e)          P=0.510      P=0.186     |P=0.625N     P=0.744N     P=0.745N     P=0.749N     | 
|POLY 1.5           |     P=0.058      (e)          P=0.505      P=0.210     |P=0.626N     P=0.749N     P=0.750N     P=0.752N     | 
|POLY 6             |     P=0.040 *    (e)          P=0.519      P=0.150     |P=0.626N     P=0.740N     P=0.742N     P=0.749N     | 
|LOGISTIC REGRESSION|     P=0.078      (e)          P=0.568      P=0.296     |P=0.583      P=0.723N     P=0.729N     P=0.692      | 
|COCH-ARM / FISHERS |     P=0.071      (e)          P=0.500      P=0.247     |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.046 *    (e)          (e)          (e)         |P=0.727N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    2/50 (4%)    2/50 (4%)   |2/50 (4%)    0/50 (0%)    2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/42.08      1/41.05      2/44.47      2/32.92     |2/44.14      0/47.49      2/47.22      6/46.14      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         4.5%         6.1%        |4.5%         0.0%         4.2%         13.0%        | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    0/38 (0%)    2/37 (5%)    4/34 (12%)   | 
|FIRST INCIDENCE    |     ---          709          708          549         |724          ---          729 (T)      679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030 *    P=0.528      P=0.310      P=0.156     |P=0.018 *    P=0.213N     P=0.652N     P=0.154      | 
|POLY 3             |     P=0.101      P=0.495      P=0.250      P=0.187     |P=0.017 *    P=0.221N     P=0.669N     P=0.147      | 
|POLY 1.5           |     P=0.128      P=0.494      P=0.244      P=0.210     |P=0.017 *    P=0.226N     P=0.676N     P=0.144      | 
|POLY 6             |     P=0.071      P=0.500      P=0.260      P=0.152     |P=0.017 *    P=0.218N     P=0.665N     P=0.148      | 
|LOGISTIC REGRESSION|     P=0.167      P=0.499      P=0.252      P=0.333     |P=0.018 *    P=0.216N     P=0.670N     P=0.144      | 
|COCH-ARM / FISHERS |     P=0.162      P=0.495      P=0.247      P=0.247     |P=0.019 *    P=0.247N     P=0.691N     P=0.134      | 
|ORDER RESTRICTED   |     P=0.116      (e)          (e)          (e)         |P=0.015 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Erythroid Cell                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  3/49 (6%)    10/50 (20%)  10/50 (20%) |8/50 (16%)   6/50 (12%)   7/50 (14%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     13/44.57     3/41.05      10/45.15     10/35.85    |8/45.92      6/48.39      7/48.30      2/45.76      | 
|POLY-3 PERCENT (g) |     29.2%        7.3%         22.2%        27.9%       |17.4%        12.4%        14.5%        4.4%         | 
|TERMINAL (d)       |     6/22 (27%)   2/27 (7%)    7/31 (23%)   0/2 (0%)    |1/32 (3%)    2/38 (5%)    3/37 (8%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     495          709          543          529         |528          609          528          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026 *    P=0.005N**   P=0.143N     P=0.066     |P=0.051N     P=0.324N     P=0.430N     P=0.051N     | 
|POLY 3             |     P=0.406      P=0.008N**   P=0.301N     P=0.549N    |P=0.049N*    P=0.347N     P=0.458N     P=0.045N*    | 
|POLY 1.5           |     P=0.477      P=0.008N**   P=0.310N     P=0.434N    |P=0.046N*    P=0.357N     P=0.468N     P=0.044N*    | 
|POLY 6             |     P=0.311      P=0.008N**   P=0.281N     P=0.462     |P=0.055N     P=0.345N     P=0.458N     P=0.050N     | 
|LOGISTIC REGRESSION|     P=0.545N     P=0.008N**   P=0.324N     P=0.241N    |P=0.063N     P=0.502N     P=0.614      P=0.055N     | 
|COCH-ARM / FISHERS |     P=0.543N     P=0.007N**   P=0.318N     P=0.318N    |P=0.046N*    P=0.387N     P=0.500N     P=0.046N*    | 
|ORDER RESTRICTED   |     P=0.209N     (e)          (e)          (e)         |P=0.041N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/50 (42%)  27/49 (55%)  20/50 (40%)  14/50 (28%) |11/50 (22%)  13/50 (26%)  20/50 (40%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     21/47.01     27/47.10     20/47.91     14/37.72    |11/46.08     13/48.83     20/49.81     13/48.56     | 
|POLY-3 PERCENT (g) |     44.7%        57.3%        41.8%        37.1%       |23.9%        26.6%        40.2%        26.8%        | 
|TERMINAL (d)       |     4/22 (18%)   11/27 (41%)  7/31 (23%)   0/2 (0%)    |4/32 (13%)   7/38 (18%)   8/37 (22%)   6/34 (18%)   | 
|FIRST INCIDENCE    |     425          373          494          487         |358          609          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.247      P=0.312      P=0.255N     P=0.145     |P=0.351      P=0.548      P=0.119      P=0.458      | 
|POLY 3             |     P=0.150N     P=0.151      P=0.468N     P=0.313N    |P=0.383      P=0.471      P=0.067      P=0.465      | 
|POLY 1.5           |     P=0.074N     P=0.139      P=0.485N     P=0.195N    |P=0.366      P=0.451      P=0.056      P=0.448      | 
|POLY 6             |     P=0.322N     P=0.178      P=0.435N     P=0.554N    |P=0.391      P=0.490      P=0.082      P=0.476      | 
|LOGISTIC REGRESSION|     P=0.004N**   P=0.140      P=0.569      P=0.021N*   |P=0.255      P=0.309      P=0.019 *    P=0.305      | 
|COCH-ARM / FISHERS |     P=0.027N*    P=0.135      P=0.500N     P=0.104N    |P=0.326      P=0.408      P=0.041 *    P=0.408      | 
|ORDER RESTRICTED   |     P=0.162N     (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   2/50 (4%)    5/50 (10%)  |2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/42.85      5/44.61      2/44.86      5/33.28     |2/44.71      1/47.49      2/47.56      0/45.76      | 
|POLY-3 PERCENT (g) |     11.7%        11.2%        4.5%         15.0%       |4.5%         2.1%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    1/2 (50%)   |0/32 (0%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     676          344          613          601         |624          729 (T)      633          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.269      P=0.618N     P=0.164N     P=0.082     |P=0.191N     P=0.462N     P=0.652N     P=0.227N     | 
|POLY 3             |     P=0.509      P=0.605N     P=0.197N     P=0.465     |P=0.201N     P=0.479N     P=0.671N     P=0.232N     | 
|POLY 1.5           |     P=0.555      P=0.615N     P=0.206N     P=0.547     |P=0.199N     P=0.484N     P=0.677N     P=0.232N     | 
|POLY 6             |     P=0.471      P=0.590N     P=0.183N     P=0.328     |P=0.204N     P=0.477N     P=0.669N     P=0.235N     | 
|LOGISTIC REGRESSION|     P=0.329N     P=0.527N     P=0.225N     P=0.452     |P=0.228N     P=0.551N     P=0.636      P=0.268N     | 
|COCH-ARM / FISHERS |     P=0.517N     P=0.630N     P=0.218N     P=0.630N    |P=0.200N     P=0.500N     P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.334      (e)          (e)          (e)         |P=0.151N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.96      4/42.47      0/44.30      0/32.01     |0/44.12      1/47.77      1/47.22      1/46.13      | 
|POLY-3 PERCENT (g) |     4.7%         9.4%         0.0%         0.0%        |0.0%         2.1%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     549          590          ---          ---         |---          653          729 (T)      624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.117N     P=0.353      P=0.239N     P=0.354N    |P=0.395      P=0.523      P=0.529      P=0.513      | 
|POLY 3             |     P=0.079N     P=0.331      P=0.230N     P=0.308N    |P=0.398      P=0.516      P=0.514      P=0.509      | 
|POLY 1.5           |     P=0.071N     P=0.331      P=0.234N     P=0.272N    |P=0.396      P=0.511      P=0.510      P=0.507      | 
|POLY 6             |     P=0.093N     P=0.340      P=0.224N     P=0.376N    |P=0.398      P=0.520      P=0.516      P=0.509      | 
|LOGISTIC REGRESSION|     P=0.045N*    P=0.363      P=0.269N     P=0.148N    |P=0.343      P=0.443      P=0.529      P=0.441      | 
|COCH-ARM / FISHERS |     P=0.061N     P=0.339      P=0.247N     P=0.247N    |P=0.384      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.098N     (e)          (e)          (e)         |P=0.337      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/44.33      2/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |                                                        |6.8%         4.2%         2.1%         0.0%         | 
|TERMINAL (d)       |                                                        |2/32 (6%)    2/38 (5%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |                                                        |673          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.056N     P=0.429N     P=0.261N     P=0.113N     | 
|POLY 3             |                                                        |P=0.060N     P=0.469N     P=0.283N     P=0.113N     | 
|POLY 1.5           |                                                        |P=0.060N     P=0.478N     P=0.289N     P=0.114N     | 
|POLY 6             |                                                        |P=0.061N     P=0.464N     P=0.280N     P=0.114N     | 
|LOGISTIC REGRESSION|                                                        |P=0.058N     P=0.465N     P=0.282N     P=0.115N     | 
|COCH-ARM / FISHERS |                                                        |P=0.062N     P=0.500N     P=0.309N     P=0.121N     | 
|ORDER RESTRICTED   |                                                        |P=0.052N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |6/44.12      1/47.49      2/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |                                                        |13.6%        2.1%         4.2%         2.2%         | 
|TERMINAL (d)       |                                                        |6/32 (19%)   1/38 (3%)    2/37 (5%)    1/34 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.043N*    P=0.034N*    P=0.090N     P=0.047N*    | 
|POLY 3             |                                                        |P=0.050N     P=0.045N*    P=0.112N     P=0.050N     | 
|POLY 1.5           |                                                        |P=0.049N*    P=0.048N*    P=0.118N     P=0.051N     | 
|POLY 6             |                                                        |P=0.051N     P=0.043N*    P=0.108N     P=0.050N     | 
|LOGISTIC REGRESSION|                                                        |P=0.043N*    P=0.034N*    P=0.090N     P=0.047N*    | 
|COCH-ARM / FISHERS |                                                        |P=0.050N     P=0.056N     P=0.134N     P=0.056N     | 
|ORDER RESTRICTED   |                                                        |P=0.011N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/44.12      2/47.49      2/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |                                                        |4.5%         4.2%         4.2%         0.0%         | 
|TERMINAL (d)       |                                                        |2/32 (6%)    2/38 (5%)    2/37 (5%)    0/34 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.153N     P=0.632N     P=0.642N     P=0.225N     | 
|POLY 3             |                                                        |P=0.159N     P=0.667N     P=0.669N     P=0.229N     | 
|POLY 1.5           |                                                        |P=0.159N     P=0.675N     P=0.676N     P=0.231N     | 
|POLY 6             |                                                        |P=0.161N     P=0.662N     P=0.665N     P=0.230N     | 
|LOGISTIC REGRESSION|                                                        |P=0.153N     P=0.632N     P=0.642N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.163N     P=0.691N     P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |                                                        |P=0.182N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/42.17      0/41.56      1/44.30      2/32.48     |                                                    | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.3%         6.2%        |                                                    | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |                                                    | 
|FIRST INCIDENCE    |     704          ---          729 (T)      641         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.044 *    P=0.480N     P=0.691N     P=0.167     |                                                    | 
|POLY 3             |     P=0.199      P=0.503N     P=0.750N     P=0.410     |                                                    | 
|POLY 1.5           |     P=0.221      P=0.503N     P=0.755N     P=0.454     |                                                    | 
|POLY 6             |     P=0.183      P=0.500N     P=0.741N     P=0.339     |                                                    | 
|LOGISTIC REGRESSION|     P=0.164      P=0.501N     P=0.736N     P=0.363     |                                                    | 
|COCH-ARM / FISHERS |     P=0.247      P=0.500N     P=0.753N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.151      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    4/50 (8%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     3/43.33      0/41.56      4/44.30      1/32.61     |                                                    | 
|POLY-3 PERCENT (g) |     6.9%         0.0%         9.0%         3.1%        |                                                    | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    4/31 (13%)   0/2 (0%)    |                                                    | 
|FIRST INCIDENCE    |     495          ---          729 (T)      537         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.508      P=0.118N     P=0.627      P=0.488N    |                                                    | 
|POLY 3             |     P=0.519N     P=0.126N     P=0.512      P=0.413N    |                                                    | 
|POLY 1.5           |     P=0.463N     P=0.124N     P=0.505      P=0.359N    |                                                    | 
|POLY 6             |     P=0.524      P=0.125N     P=0.527      P=0.507N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.357N     P=0.080N     P=0.478      P=0.145N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.121N     P=0.500      P=0.309N    |                                                    | 
|ORDER RESTRICTED   |     P=0.368N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |1/44.12      1/47.49      2/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         2.1%         4.2%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    2/37 (5%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.599      P=0.723N     P=0.551      P=0.748N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.597      P=0.744N     P=0.524      P=0.753N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.597      P=0.749N     P=0.517      P=0.754N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.592      P=0.740N     P=0.528      P=0.754N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.599      P=0.723N     P=0.551      P=0.748N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.591      P=0.753N     P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.597      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/42.73      0/41.56      1/44.46      0/32.01     |1/44.12      1/47.49      2/47.22      2/45.95      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         2.3%         0.0%        |2.3%         2.1%         4.2%         4.4%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    2/37 (5%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     632          ---          687          ---         |729 (T)      729 (T)      729 (T)      679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.290N     P=0.256N     P=0.469N     P=0.408N    |P=0.341      P=0.723N     P=0.551      P=0.522      | 
|POLY 3             |     P=0.204N     P=0.243N     P=0.486N     P=0.306N    |P=0.345      P=0.744N     P=0.524      P=0.514      | 
|POLY 1.5           |     P=0.197N     P=0.242N     P=0.493N     P=0.271N    |P=0.345      P=0.749N     P=0.517      P=0.511      | 
|POLY 6             |     P=0.222N     P=0.242N     P=0.474N     P=0.374N    |P=0.343      P=0.740N     P=0.528      P=0.514      | 
|LOGISTIC REGRESSION|     P=0.168N     P=0.219N     P=0.524N     P=0.193N    |P=0.338      P=0.723N     P=0.551      P=0.511      | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.247N     P=0.500N     P=0.247N    |P=0.337      P=0.753N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.125N     (e)          (e)          (e)         |P=0.450      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    5/50 (10%)   0/50 (0%)   |2/50 (4%)    2/50 (4%)    4/50 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     5/43.22      2/41.62      5/44.85      0/32.01     |2/44.14      2/47.77      4/47.22      4/45.95      | 
|POLY-3 PERCENT (g) |     11.6%        4.8%         11.2%        0.0%        |4.5%         4.2%         8.5%         8.7%         | 
|TERMINAL (d)       |     0/22 (0%)    1/27 (4%)    1/31 (3%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    4/37 (11%)   3/34 (9%)    | 
|FIRST INCIDENCE    |     632          715          687          ---         |724          653          729 (T)      679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.255N     P=0.211N     P=0.514N     P=0.215N    |P=0.213      P=0.644N     P=0.397      P=0.359      | 
|POLY 3             |     P=0.111N     P=0.231N     P=0.607N     P=0.065N    |P=0.217      P=0.665N     P=0.369      P=0.356      | 
|POLY 1.5           |     P=0.078N     P=0.227N     P=0.618N     P=0.045N*   |P=0.218      P=0.674N     P=0.360      P=0.352      | 
|POLY 6             |     P=0.190N     P=0.232N     P=0.588N     P=0.118N    |P=0.213      P=0.658N     P=0.375      P=0.355      | 
|LOGISTIC REGRESSION|     P=0.077N     P=0.219N     P=0.626      P=0.035N*   |P=0.213      P=0.684N     P=0.370      P=0.350      | 
|COCH-ARM / FISHERS |     P=0.054N     P=0.218N     P=0.630N     P=0.028N*   |P=0.210      P=0.691N     P=0.339      P=0.339      | 
|ORDER RESTRICTED   |     P=0.051N     (e)          (e)          (e)         |P=0.325      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   4/50 (8%)    9/50 (18%)   3/50 (6%)   |14/50 (28%)  10/50 (20%)  6/50 (12%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     9/42.66      4/41.56      9/45.76      3/33.89     |14/44.35     10/48.02     6/47.22      9/46.17      | 
|POLY-3 PERCENT (g) |     21.1%        9.6%         19.7%        8.9%        |31.6%        20.8%        12.7%        19.5%        | 
|TERMINAL (d)       |     7/22 (32%)   4/27 (15%)   6/31 (19%)   0/2 (0%)    |11/32 (34%)  8/38 (21%)   6/37 (16%)   7/34 (21%)   | 
|FIRST INCIDENCE    |     638          729 (T)      543          487         |697          613          729 (T)      638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.500      P=0.060N     P=0.368N     P=0.542     |P=0.124N     P=0.134N     P=0.019N*    P=0.145N     | 
|POLY 3             |     P=0.193N     P=0.122N     P=0.539N     P=0.125N    |P=0.122N     P=0.173N     P=0.025N*    P=0.139N     | 
|POLY 1.5           |     P=0.143N     P=0.122N     P=0.568N     P=0.088N    |P=0.123N     P=0.194N     P=0.028N*    P=0.146N     | 
|POLY 6             |     P=0.287N     P=0.118N     P=0.491N     P=0.220N    |P=0.125N     P=0.159N     P=0.023N*    P=0.138N     | 
|LOGISTIC REGRESSION|     P=0.139N     P=0.101N     P=0.583N     P=0.081N    |P=0.122N     P=0.169N     P=0.023N*    P=0.148N     | 
|COCH-ARM / FISHERS |     P=0.103N     P=0.117N     P=0.602N     P=0.061N    |P=0.132N     P=0.241N     P=0.039N*    P=0.171N     | 
|ORDER RESTRICTED   |     P=0.117N     (e)          (e)          (e)         |P=0.051N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  48/50 (96%)  47/50 (94%)  49/50 (98%) |46/50 (92%)  46/50 (92%)  48/50 (96%)  46/50 (92%)  | 
|POLY-3 RATE (b)    |     48/49.67     48/48.24     47/49.53     49/49.92    |46/48.16     46/49.57     48/49.38     46/49.09     | 
|POLY-3 PERCENT (g) |     96.6%        99.5%        94.9%        98.2%       |95.5%        92.8%        97.2%        93.7%        | 
|TERMINAL (d)       |     21/22 (96%)  27/27 (100%) 29/31 (94%)  2/2 (100%)  |31/32 (97%)  36/38 (95%)  36/37 (97%)  32/34 (94%)  | 
|FIRST INCIDENCE    |     425          484          486          487         |430          609          609          528          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.257N     P=0.044N*    P<0.001 **  |P=0.515N     P=0.133N     P=0.295N     P=0.415N     | 
|POLY 3             |     P=0.566      P=0.370      P=0.528N     P=0.563     |P=0.523N     P=0.443N     P=0.539      P=0.522N     | 
|POLY 1.5           |     P=0.510      P=0.471      P=0.517N     P=0.533     |P=0.527N     P=0.482N     P=0.497      P=0.536N     | 
|POLY 6             |     P=0.612      P=0.357      P=0.536N     P=0.609     |P=0.551N     P=0.466N     P=0.528      P=0.555N     | 
|LOGISTIC REGRESSION|     P=0.280      P=0.535      P=0.495N     P=0.720     |P=0.414N     P=0.341N     P=0.664N     P=0.411N     | 
|COCH-ARM / FISHERS |     P=0.404      P=0.691N     P=0.500N     P=0.500     |P=0.537      P=0.643N     P=0.339      P=0.643N     | 
|ORDER RESTRICTED   |     P=0.483      (e)          (e)          (e)         |P=0.530N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      2/44.31      6/33.68     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         17.8%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          726          604         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.316      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P=0.249      P=0.006 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.243      P=0.010 *   |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P=0.259      P=0.003 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.300      P=0.010 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.247      P=0.013 *   |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/42.48      5/42.82      2/44.89      1/32.54     |0/44.12      1/47.90      0/47.22      1/46.04      | 
|POLY-3 PERCENT (g) |     7.1%         11.7%        4.5%         3.1%        |0.0%         2.1%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     676          484          543          569         |---          613          ---          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.363N     P=0.404      P=0.417N     P=0.689N    |P=0.414      P=0.517      (e)          P=0.519      | 
|POLY 3             |     P=0.201N     P=0.360      P=0.475N     P=0.406N    |P=0.419      P=0.516      (e)          P=0.509      | 
|POLY 1.5           |     P=0.169N     P=0.356      P=0.486N     P=0.355N    |P=0.416      P=0.511      (e)          P=0.507      | 
|POLY 6             |     P=0.253N     P=0.372      P=0.457N     P=0.498N    |P=0.419      P=0.521      (e)          P=0.509      | 
|LOGISTIC REGRESSION|     P=0.102N     P=0.365      P=0.518N     P=0.338N    |P=0.324      P=0.390      (e)          P=0.468      | 
|COCH-ARM / FISHERS |     P=0.135N     P=0.357      P=0.500N     P=0.309N    |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.244N     (e)          (e)          (e)         |P=0.259      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Endocardium                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      2/41.56      0/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.689N     P=0.284      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.431N     P=0.234      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.422N     P=0.234      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.454N     P=0.237      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.284      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.303N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      4/33.59     |0/44.12      1/47.91      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         11.9%       |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          593         |---          609          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.027 *   |P=0.565N     P=0.521      (e)          (e)          | 
|POLY 3             |     P=0.002 **   (e)          (e)          P=0.036 *   |P=0.552N     P=0.516      (e)          (e)          | 
|POLY 1.5           |     P=0.002 **   (e)          (e)          P=0.046 *   |P=0.557N     P=0.511      (e)          (e)          | 
|POLY 6             |     P=0.002 **   (e)          (e)          P=0.023 *   |P=0.549N     P=0.521      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.008 **   (e)          (e)          P=0.099     |P=0.652N     P=0.385      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.003 **   (e)          (e)          P=0.059     |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.389N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      2/32.78     |0/44.12      0/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         6.1%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          604         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023 *    (e)          (e)          P=0.155     |P=0.700      (e)          P=0.529      (e)          | 
|POLY 3             |     P=0.039 *    (e)          (e)          P=0.186     |P=0.698      (e)          P=0.514      (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.210     |P=0.698      (e)          P=0.510      (e)          | 
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.151     |P=0.693      (e)          P=0.516      (e)          | 
|LOGISTIC REGRESSION|     P=0.069      (e)          (e)          P=0.295     |(e)          (e)          P=0.529      (e)          | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.015 *    (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/42.08      1/41.84      1/44.38      0/32.01     |1/44.12      3/47.49      2/47.22      3/45.93      | 
|POLY-3 PERCENT (g) |     2.4%         2.4%         2.3%         0.0%        |2.3%         6.3%         4.2%         6.5%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    3/38 (8%)    2/37 (5%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      653          708          ---         |729 (T)      729 (T)      729 (T)      686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.523N     P=0.741N     P=0.685N     P=0.934N    |P=0.302      P=0.368      P=0.551      P=0.323      | 
|POLY 3             |     P=0.359N     P=0.760      P=0.749N     P=0.554N    |P=0.318      P=0.332      P=0.524      P=0.320      | 
|POLY 1.5           |     P=0.338N     P=0.758      P=0.754N     P=0.527N    |P=0.315      P=0.324      P=0.517      P=0.317      | 
|POLY 6             |     P=0.405N     P=0.758N     P=0.739N     P=0.598N    |P=0.316      P=0.338      P=0.528      P=0.319      | 
|LOGISTIC REGRESSION|     P=0.377N     P=0.760      P=0.732N     (e)         |P=0.295      P=0.368      P=0.551      P=0.316      | 
|COCH-ARM / FISHERS |     P=0.311N     P=0.753N     P=0.753N     P=0.500N    |P=0.302      P=0.309      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.383N     (e)          (e)          (e)         |P=0.283      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   8/50 (16%)   5/50 (10%)  |8/50 (16%)   8/50 (16%)   14/50 (28%)  6/50 (12%)   | 
|POLY-3 RATE (b)    |     6/43.91      6/41.96      8/45.23      5/33.28     |8/45.08      8/47.99      14/47.22     6/45.76      | 
|POLY-3 PERCENT (g) |     13.7%        14.3%        17.7%        15.0%       |17.8%        16.7%        29.7%        13.1%        | 
|TERMINAL (d)       |     3/22 (14%)   4/27 (15%)   5/31 (16%)   1/2 (50%)   |6/32 (19%)   5/38 (13%)   14/37 (38%)  6/34 (18%)   | 
|FIRST INCIDENCE    |     425          641          499          537         |528          633          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.077      P=0.534N     P=0.570      P=0.128     |P=0.384N     P=0.479N     P=0.195      P=0.341N     | 
|POLY 3             |     P=0.433      P=0.589      P=0.409      P=0.562     |P=0.405N     P=0.554N     P=0.135      P=0.375N     | 
|POLY 1.5           |     P=0.538      P=0.597      P=0.397      P=0.601N    |P=0.396N     P=0.569N     P=0.130      P=0.373N     | 
|POLY 6             |     P=0.297      P=0.593      P=0.436      P=0.407     |P=0.428N     P=0.544N     P=0.134      P=0.386N     | 
|LOGISTIC REGRESSION|     P=0.486N     P=0.612N     P=0.343      P=0.382N    |P=0.385N     P=0.607N     P=0.148      P=0.366N     | 
|COCH-ARM / FISHERS |     P=0.457N     P=0.620N     P=0.387      P=0.500N    |P=0.402N     P=0.607N     P=0.114      P=0.387N     | 
|ORDER RESTRICTED   |     P=0.578      (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |0/44.12      1/47.49      2/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.1%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    1/38 (3%)    2/37 (5%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.615N     P=0.534      P=0.271      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.605N     P=0.515      P=0.253      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.607N     P=0.510      P=0.248      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.608N     P=0.518      P=0.256      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.534      P=0.271      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.616N     P=0.500      P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.337N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    4/50 (8%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/43.30      1/41.56      4/44.99      2/32.50     |0/44.12      0/47.49      2/47.84      1/46.25      | 
|POLY-3 PERCENT (g) |     9.2%         2.4%         8.9%         6.2%        |0.0%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    3/31 (10%)   0/2 (0%)    |0/32 (0%)    0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          729 (T)      494          613         |---          ---          528          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414      P=0.168N     P=0.538N     P=0.626     |P=0.250      (e)          P=0.263      P=0.513      | 
|POLY 3             |     P=0.507N     P=0.190N     P=0.622N     P=0.476N    |P=0.253      (e)          P=0.256      P=0.509      | 
|POLY 1.5           |     P=0.456N     P=0.187N     P=0.632N     P=0.407N    |P=0.252      (e)          P=0.250      P=0.507      | 
|POLY 6             |     P=0.536      P=0.190N     P=0.606N     P=0.593N    |P=0.251      (e)          P=0.260      P=0.510      | 
|LOGISTIC REGRESSION|     P=0.365N     P=0.166N     P=0.604      P=0.282N    |P=0.143      (e)          P=0.140      P=0.395      | 
|COCH-ARM / FISHERS |     P=0.397N     P=0.181N     P=0.643N     P=0.339N    |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.462N     (e)          (e)          (e)         |P=0.183      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.26      3/42.47      0/44.30      0/32.01     |0/44.12      1/47.77      2/47.58      1/45.95      | 
|POLY-3 PERCENT (g) |     2.4%         7.1%         0.0%         0.0%        |0.0%         2.1%         4.2%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    1/27 (4%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     680          526          ---          ---         |---          653          662          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.248N     P=0.322      P=0.468N     P=0.713N    |P=0.370      P=0.523      P=0.261      P=0.505      | 
|POLY 3             |     P=0.176N     P=0.306      P=0.491N     P=0.554N    |P=0.379      P=0.516      P=0.254      P=0.508      | 
|POLY 1.5           |     P=0.166N     P=0.304      P=0.495N     P=0.528N    |P=0.377      P=0.511      P=0.249      P=0.506      | 
|POLY 6             |     P=0.195N     P=0.315      P=0.483N     P=0.599N    |P=0.376      P=0.520      P=0.259      P=0.508      | 
|LOGISTIC REGRESSION|     P=0.128N     P=0.322      P=0.504N     P=0.584N    |P=0.328      P=0.443      P=0.209      P=0.491      | 
|COCH-ARM / FISHERS |     P=0.153N     P=0.309      P=0.500N     P=0.500N    |P=0.366      P=0.500      P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.170N     (e)          (e)          (e)         |P=0.241      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 45/50 (90%)  50/50 (100%) 50/50 (100%)|47/50 (94%)  49/50 (98%)  48/50 (96%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     50/50.00     45/47.44     50/50.00     50/50.00    |47/48.85     49/49.87     48/49.90     49/49.29     | 
|POLY-3 PERCENT (g) |     100.0%       94.9%        100.0%       100.0%      |96.2%        98.3%        96.2%        99.4%        | 
|TERMINAL (d)       |     22/22 (100%) 26/27 (96%)  31/31 (100%) 2/2 (100%)  |31/32 (97%)  38/38 (100%) 37/37 (100%) 34/34 (100%) | 
|FIRST INCIDENCE    |     425          344          486          487         |358          609          528          528          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.083N     (e)          (e)         |P=0.461      P=0.215N     P=0.229N     P=0.548N     | 
|POLY 3             |     P=0.335      P=0.116N     (e)          (e)         |P=0.280      P=0.499      P=0.705N     P=0.330      | 
|POLY 1.5           |     P=0.257      P=0.059N     (e)          (e)         |P=0.295      P=0.445      P=0.658      P=0.337      | 
|POLY 6             |     P=0.456      P=0.263N     (e)          (e)         |P=0.263      P=0.532      P=0.691N     P=0.320      | 
|LOGISTIC REGRESSION|     P=0.136      P=0.051N     (e)          (e)         |P=0.453      P=0.536      P=0.689      P=0.560      | 
|COCH-ARM / FISHERS |     P=0.199      P=0.028N*    (e)          (e)         |P=0.279      P=0.309      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.119      (e)          (e)          (e)         |P=0.219      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    4/50 (8%)    14/50 (28%) |2/50 (4%)    1/50 (2%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.08      1/42.46      4/44.41      14/37.07    |2/44.12      1/47.49      4/47.56      1/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         9.0%         37.8%       |4.5%         2.1%         8.4%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |2/32 (6%)    1/38 (3%)    3/37 (8%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          344          705          488         |729 (T)      729 (T)      633          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.500      P=0.118      P<0.001 **  |P=0.491N     P=0.440N     P=0.403      P=0.479N     | 
|POLY 3             |     P<0.001 **   P=0.502      P=0.067      P<0.001 **  |P=0.496N     P=0.474N     P=0.373      P=0.487N     | 
|POLY 1.5           |     P<0.001 **   P=0.500      P=0.064      P<0.001 **  |P=0.495N     P=0.482N     P=0.362      P=0.490N     | 
|POLY 6             |     P<0.001 **   P=0.506      P=0.073      P<0.001 **  |P=0.502N     P=0.469N     P=0.381      P=0.489N     | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.086      P<0.001 **  |P=0.494N     P=0.440N     P=0.362      P=0.479N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.059      P<0.001 **  |P=0.500N     P=0.500N     P=0.339      P=0.500N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.407N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Medulla                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  49/50 (98%)  47/50 (94%)  49/50 (98%) |43/50 (86%)  49/50 (98%)  49/50 (98%)  46/50 (92%)  | 
|POLY-3 RATE (b)    |     47/49.19     49/49.88     47/49.84     49/49.30    |43/48.66     49/50.00     49/49.85     46/50.00     | 
|POLY-3 PERCENT (g) |     95.6%        98.2%        94.3%        99.4%       |88.4%        98.0%        98.3%        92.0%        | 
|TERMINAL (d)       |     21/22 (96%)  27/27 (100%) 29/31 (94%)  2/2 (100%)  |27/32 (84%)  37/38 (97%)  37/37 (100%) 30/34 (88%)  | 
|FIRST INCIDENCE    |     425          344          486          488         |358          609          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.361N     P=0.060N     P<0.001 **  |P=0.446      P=0.518N     P=0.549      P=0.507      | 
|POLY 3             |     P=0.268      P=0.417      P=0.573N     P=0.254     |P=0.464      P=0.061      P=0.050      P=0.394      | 
|POLY 1.5           |     P=0.277      P=0.364      P=0.613N     P=0.265     |P=0.414      P=0.049 *    P=0.044 *    P=0.353      | 
|POLY 6             |     P=0.284      P=0.498      P=0.519N     P=0.282     |P=0.505      P=0.073      P=0.051      P=0.430      | 
|LOGISTIC REGRESSION|     P=0.283      P=0.295      P=0.657N     P=0.179     |P=0.340      P=0.053      P=0.054      P=0.290      | 
|COCH-ARM / FISHERS |     P=0.313      P=0.309      P=0.661N     P=0.309     |P=0.297      P=0.030 *    P=0.030 *    P=0.262      | 
|ORDER RESTRICTED   |     P=0.187      (e)          (e)          (e)         |P=0.069      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      1/44.30      1/32.15     |1/44.12      0/47.49      4/47.58      2/46.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         3.1%        |2.3%         0.0%         8.4%         4.3%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |1/32 (3%)    0/38 (0%)    2/37 (5%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      694         |729 (T)      ---          662          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.041 *    (e)          P=0.568      P=0.261     |P=0.240      P=0.466N     P=0.223      P=0.521      | 
|POLY 3             |     P=0.166      (e)          P=0.510      P=0.447     |P=0.245      P=0.485N     P=0.203      P=0.518      | 
|POLY 1.5           |     P=0.199      (e)          P=0.505      P=0.473     |P=0.244      P=0.490N     P=0.195      P=0.514      | 
|POLY 6             |     P=0.132      (e)          P=0.519      P=0.404     |P=0.241      P=0.482N     P=0.209      P=0.519      | 
|LOGISTIC REGRESSION|     P=0.102      (e)          P=0.568      P=0.359     |P=0.205      (e)          P=0.191      P=0.435      | 
|COCH-ARM / FISHERS |     P=0.235      (e)          P=0.500      P=0.500     |P=0.237      P=0.500N     P=0.181      P=0.500      | 
|ORDER RESTRICTED   |     P=0.204      (e)          (e)          (e)         |P=0.147      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    11/50 (22%)  29/50 (58%)  34/50 (68%) |1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/42.16      11/41.80     29/45.78     34/43.12    |1/44.12      2/47.77      2/47.22      4/46.04      | 
|POLY-3 PERCENT (g) |     2.4%         26.3%        63.3%        78.9%       |2.3%         4.2%         4.2%         8.7%         | 
|TERMINAL (d)       |     0/22 (0%)    9/27 (33%)   21/31 (68%)  1/2 (50%)   |1/32 (3%)    1/38 (3%)    2/37 (5%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     709          698          590          488         |729 (T)      653          729 (T)      659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **  |P=0.116      P=0.553      P=0.551      P=0.202      | 
|POLY 3             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P=0.119      P=0.528      P=0.524      P=0.192      | 
|POLY 1.5           |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P=0.119      P=0.519      P=0.517      P=0.189      | 
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P=0.118      P=0.535      P=0.528      P=0.192      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P=0.115      P=0.504      P=0.551      P=0.189      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P=0.113      P=0.500      P=0.500      P=0.181      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.126      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    9/50 (18%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      1/44.30      9/34.63     |0/44.12      0/47.49      0/47.22      1/45.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         26.0%       |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      604         |---          ---          ---          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.568      P<0.001 **  |P=0.200      (e)          (e)          P=0.514      | 
|POLY 3             |     P<0.001 **   (e)          P=0.510      P<0.001 **  |P=0.200      (e)          (e)          P=0.508      | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.505      P<0.001 **  |P=0.200      (e)          (e)          P=0.506      | 
|POLY 6             |     P<0.001 **   (e)          P=0.519      P<0.001 **  |P=0.199      (e)          (e)          P=0.508      | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.568      P<0.001 **  |P=0.187      (e)          (e)          P=0.489      | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.500      P<0.001 **  |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.128      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   20/50 (40%)  23/50 (46%) |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.23      5/41.56      20/45.31     23/39.89    |0/44.12      1/47.49      1/47.30      1/45.95      | 
|POLY-3 PERCENT (g) |     2.4%         12.0%        44.1%        57.7%       |0.0%         2.1%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    5/27 (19%)   14/31 (45%)  0/2 (0%)    |0/32 (0%)    1/38 (3%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     690          729 (T)      624          529         |---          729 (T)      709          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.149      P<0.001 **   P<0.001 **  |P=0.386      P=0.534      P=0.516      P=0.514      | 
|POLY 3             |     P<0.001 **   P=0.096      P<0.001 **   P<0.001 **  |P=0.397      P=0.515      P=0.514      P=0.508      | 
|POLY 1.5           |     P<0.001 **   P=0.097      P<0.001 **   P<0.001 **  |P=0.395      P=0.510      P=0.510      P=0.506      | 
|POLY 6             |     P<0.001 **   P=0.098      P<0.001 **   P<0.001 **  |P=0.396      P=0.518      P=0.517      P=0.508      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.116      P<0.001 **   P<0.001 **  |P=0.384      P=0.534      P=0.508      P=0.489      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.102      P<0.001 **   P<0.001 **  |P=0.384      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.336      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.09      1/41.67      2/44.77      0/32.01     |0/44.12      0/47.49      0/47.22      1/46.09      | 
|POLY-3 PERCENT (g) |     2.4%         2.4%         4.5%         0.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     726          702          590          ---         |---          ---          ---          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.613N     P=0.728N     P=0.582      P=0.886N    |P=0.206      (e)          (e)          P=0.523      | 
|POLY 3             |     P=0.457N     P=0.759      P=0.522      P=0.554N    |P=0.201      (e)          (e)          P=0.509      | 
|POLY 1.5           |     P=0.414N     P=0.758      P=0.511      P=0.527N    |P=0.201      (e)          (e)          P=0.507      | 
|POLY 6             |     P=0.544N     P=0.760N     P=0.539      P=0.598N    |P=0.200      (e)          (e)          P=0.509      | 
|LOGISTIC REGRESSION|     P=0.417N     P=0.759N     P=0.495      P=0.858N    |P=0.158      (e)          (e)          P=0.455      | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.753N     P=0.500      P=0.500N    |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.337N     (e)          (e)          (e)         |P=0.129      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    5/50 (10%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.08      1/41.56      0/44.30      0/32.01     |2/44.20      2/47.57      5/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         0.0%        |4.5%         4.2%         10.6%        2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    1/27 (4%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    5/37 (14%)   1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |708          710          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.814N     P=0.541      (e)          (e)         |P=0.456N     P=0.647N     P=0.272      P=0.492N     | 
|POLY 3             |     P=0.560N     P=0.498      (e)          (e)         |P=0.448N     P=0.667N     P=0.244      P=0.488N     | 
|POLY 1.5           |     P=0.568N     P=0.497      (e)          (e)         |P=0.448N     P=0.675N     P=0.236      P=0.490N     | 
|POLY 6             |     P=0.563N     P=0.501      (e)          (e)         |P=0.456N     P=0.662N     P=0.248      P=0.490N     | 
|LOGISTIC REGRESSION|     (e)          P=0.541      (e)          (e)         |P=0.462N     P=0.666N     P=0.248      P=0.492N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.456N     P=0.691N     P=0.218      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.428N     (e)          (e)          (e)         |P=0.297N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     24/50 (48%)  25/50 (50%)  32/50 (64%)  19/50 (38%) |48/50 (96%)  48/50 (96%)  41/50 (82%)  43/50 (86%)  | 
|POLY-3 RATE (b)    |     24/43.26     25/41.77     32/46.14     19/37.67    |48/49.04     48/49.60     41/48.16     43/48.26     | 
|POLY-3 PERCENT (g) |     55.5%        59.9%        69.4%        50.4%       |97.9%        96.8%        85.1%        89.1%        | 
|TERMINAL (d)       |     19/22 (86%)  22/27 (82%)  25/31 (81%)  0/2 (0%)    |32/32 (100%) 37/38 (97%)  36/37 (97%)  33/34 (97%)  | 
|FIRST INCIDENCE    |     495          709          499          488         |358          609          609          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.254N     P=0.541N     P<0.001 **  |P=0.089N     P=0.122N     P=0.006N**   P=0.114N     | 
|POLY 3             |     P=0.419N     P=0.422      P=0.115      P=0.403N    |P=0.024N*    P=0.619N     P=0.019N*    P=0.066N     | 
|POLY 1.5           |     P=0.296N     P=0.445      P=0.094      P=0.299N    |P=0.020N*    P=0.617N     P=0.016N*    P=0.056N     | 
|POLY 6             |     P=0.461      P=0.420      P=0.167      P=0.597N    |P=0.045N*    P=0.668N     P=0.032N*    P=0.116N     | 
|LOGISTIC REGRESSION|     P=0.102      P=0.596N     P=0.140      P=0.303     |P=0.009N**   P=0.441N     P=0.004N**   P=0.028N*    | 
|COCH-ARM / FISHERS |     P=0.195N     P=0.500      P=0.079      P=0.210N    |P=0.028N*    P=0.691N     P=0.026N*    P=0.080N     | 
|ORDER RESTRICTED   |     P=0.219N     (e)          (e)          (e)         |P=0.018N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  19/50 (38%)  18/50 (36%)  0/50 (0%)   |15/50 (30%)  13/50 (26%)  10/50 (20%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     19/42.17     19/41.72     18/44.89     0/32.01     |15/44.20     13/47.49     10/47.33     10/45.93     | 
|POLY-3 PERCENT (g) |     45.1%        45.6%        40.1%        0.0%        |33.9%        27.4%        21.1%        21.8%        | 
|TERMINAL (d)       |     18/22 (82%)  17/27 (63%)  17/31 (55%)  0/2 (0%)    |14/32 (44%)  13/38 (34%)  9/37 (24%)   9/34 (27%)   | 
|FIRST INCIDENCE    |     704          704          543          ---         |708          729 (T)      701          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.009N**   P=0.224N     P=0.051N     P=0.047N*   |P=0.110N     P=0.214N     P=0.086N     P=0.130N     | 
|POLY 3             |     P<0.001N**   P=0.571      P=0.399N     P<0.001N**  |P=0.116N     P=0.325N     P=0.126N     P=0.144N     | 
|POLY 1.5           |     P<0.001N**   P=0.565      P=0.447N     P<0.001N**  |P=0.119N     P=0.350N     P=0.141N     P=0.152N     | 
|POLY 6             |     P<0.001N**   P=0.584N     P=0.320N     P<0.001N**  |P=0.118N     P=0.307N     P=0.116N     P=0.143N     | 
|LOGISTIC REGRESSION|     P=0.004N**   P=0.334N     P=0.187N     P=0.018N*   |P=0.140N     P=0.287N     P=0.119N     P=0.170N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.582N     P=0.500N     P<0.001N**  |P=0.131N     P=0.412N     P=0.178N     P=0.178N     | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.139N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   11/50 (22%)  20/50 (40%)  15/50 (30%) |1/50 (2%)    0/50 (0%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     8/42.99      11/42.86     20/44.87     15/36.32    |1/44.12      0/47.49      3/47.30      4/45.82      | 
|POLY-3 PERCENT (g) |     18.6%        25.7%        44.6%        41.3%       |2.3%         0.0%         6.3%         8.7%         | 
|TERMINAL (d)       |     2/22 (9%)    6/27 (22%)   14/31 (45%)  1/2 (50%)   |1/32 (3%)    0/38 (0%)    1/37 (3%)    3/34 (9%)    | 
|FIRST INCIDENCE    |     676          590          687          529         |729 (T)      ---          709          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.414      P=0.076      P<0.001 **  |P=0.042 *    P=0.466N     P=0.357      P=0.194      | 
|POLY 3             |     P=0.007 **   P=0.298      P=0.006 **   P=0.020 *   |P=0.043 *    P=0.485N     P=0.331      P=0.190      | 
|POLY 1.5           |     P=0.018 *    P=0.296      P=0.006 **   P=0.040 *   |P=0.044 *    P=0.490N     P=0.323      P=0.188      | 
|POLY 6             |     P<0.001 **   P=0.311      P=0.008 **   P=0.005 **  |P=0.042 *    P=0.482N     P=0.336      P=0.189      | 
|LOGISTIC REGRESSION|     P=0.003 **   P=0.295      P=0.014 *    P=0.020 *   |P=0.040 *    (e)          P=0.334      P=0.178      | 
|COCH-ARM / FISHERS |     P=0.048 *    P=0.306      P=0.007 **   P=0.077     |P=0.044 *    P=0.500N     P=0.309      P=0.181      | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |P=0.056      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   14/50 (28%)  10/50 (20%)  9/50 (18%)  |0/50 (0%)    6/50 (12%)   6/50 (12%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     5/42.43      14/41.74     10/45.05     9/35.47     |0/44.12      6/47.49      6/47.22      9/45.93      | 
|POLY-3 PERCENT (g) |     11.8%        33.5%        22.2%        25.4%       |0.0%         12.6%        12.7%        19.6%        | 
|TERMINAL (d)       |     3/22 (14%)   12/27 (44%)  8/31 (26%)   0/2 (0%)    |0/32 (0%)    6/38 (16%)   6/37 (16%)   8/34 (24%)   | 
|FIRST INCIDENCE    |     634          704          543          507         |---          729 (T)      729 (T)      686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.049 *    P=0.300      P=0.002 **  |P=0.005 **   P=0.028 *    P=0.026 *    P=0.003 **   | 
|POLY 3             |     P=0.207      P=0.014 *    P=0.155      P=0.101     |P=0.006 **   P=0.020 *    P=0.019 *    P=0.002 **   | 
|POLY 1.5           |     P=0.284      P=0.015 *    P=0.143      P=0.142     |P=0.006 **   P=0.018 *    P=0.018 *    P=0.002 **   | 
|POLY 6             |     P=0.117      P=0.014 *    P=0.178      P=0.051     |P=0.006 **   P=0.020 *    P=0.020 *    P=0.002 **   | 
|LOGISTIC REGRESSION|     P=0.149      P=0.023 *    P=0.159      P=0.214     |P=0.004 **   P=0.028 *    P=0.026 *    P=0.003 **   | 
|COCH-ARM / FISHERS |     P=0.381      P=0.020 *    P=0.131      P=0.194     |P=0.006 **   P=0.013 *    P=0.013 *    P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.089      (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  20/50 (40%)  22/50 (44%)  15/50 (30%) |11/50 (22%)  8/50 (16%)   9/50 (18%)   20/50 (40%)  | 
|POLY-3 RATE (b)    |     22/47.41     20/47.19     22/47.99     15/37.37    |11/46.98     8/48.87      9/47.96      20/47.86     | 
|POLY-3 PERCENT (g) |     46.4%        42.4%        45.8%        40.1%       |23.4%        16.4%        18.8%        41.8%        | 
|TERMINAL (d)       |     2/22 (9%)    5/27 (19%)   12/31 (39%)  0/2 (0%)    |2/32 (6%)    4/38 (11%)   4/37 (11%)   11/34 (32%)  | 
|FIRST INCIDENCE    |     425          344          486          488         |288          609          633          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.110      P=0.364N     P=0.298N     P=0.101     |P=0.016 *    P=0.237N     P=0.327N     P=0.083      | 
|POLY 3             |     P=0.362N     P=0.426N     P=0.560N     P=0.359N    |P=0.008 **   P=0.272N     P=0.381N     P=0.043 *    | 
|POLY 1.5           |     P=0.219N     P=0.423N     P=0.566N     P=0.215N    |P=0.008 **   P=0.284N     P=0.387N     P=0.042 *    | 
|POLY 6             |     P=0.464      P=0.433N     P=0.559N     P=0.548     |P=0.008 **   P=0.262N     P=0.378N     P=0.044 *    | 
|LOGISTIC REGRESSION|     P=0.019N*    P=0.372N     P=0.476      P=0.040N*   |P=0.005 **   P=0.558N     P=0.572N     P=0.025 *    | 
|COCH-ARM / FISHERS |     P=0.098N     P=0.420N     P=0.580N     P=0.107N    |P=0.009 **   P=0.306N     P=0.402N     P=0.041 *    | 
|ORDER RESTRICTED   |     P=0.455N     (e)          (e)          (e)         |P=0.007 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    2/50 (4%)    4/50 (8%)   |1/50 (2%)    6/50 (12%)   4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/43.01      1/41.64      2/44.30      4/34.20     |1/44.12      6/47.63      4/47.55      2/45.76      | 
|POLY-3 PERCENT (g) |     9.3%         2.4%         4.5%         11.7%       |2.3%         12.6%        8.4%         4.4%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |1/32 (3%)    5/38 (13%)   2/37 (5%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     549          709          729 (T)      529         |729 (T)      693          662          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.156      P=0.168N     P=0.249N     P=0.323     |P=0.515N     P=0.089      P=0.223      P=0.521      | 
|POLY 3             |     P=0.371      P=0.188N     P=0.323N     P=0.513     |P=0.492N     P=0.069      P=0.202      P=0.513      | 
|POLY 1.5           |     P=0.401      P=0.186N     P=0.330N     P=0.578     |P=0.497N     P=0.065      P=0.195      P=0.510      | 
|POLY 6             |     P=0.339      P=0.186N     P=0.310N     P=0.401     |P=0.495N     P=0.073      P=0.208      P=0.511      | 
|LOGISTIC REGRESSION|     P=0.537      P=0.176N     P=0.342N     P=0.433N    |P=0.513N     P=0.074      P=0.193      P=0.521      | 
|COCH-ARM / FISHERS |     P=0.437      P=0.181N     P=0.339N     P=0.643N    |P=0.519N     P=0.056      P=0.181      P=0.500      | 
|ORDER RESTRICTED   |     P=0.233      (e)          (e)          (e)         |P=0.197      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   1/50 (2%)    1/50 (2%)   |5/50 (10%)   6/50 (12%)   6/50 (12%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/42.36      6/42.03      1/44.30      1/32.54     |5/44.18      6/47.84      6/47.41      6/46.02      | 
|POLY-3 PERCENT (g) |     4.7%         14.3%        2.3%         3.1%        |11.3%        12.5%        12.7%        13.0%        | 
|TERMINAL (d)       |     0/22 (0%)    5/27 (19%)   1/31 (3%)    0/2 (0%)    |2/32 (6%)    5/38 (13%)   5/37 (14%)   5/34 (15%)   | 
|FIRST INCIDENCE    |     680          590          729 (T)      569         |724          633          679          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.489N     P=0.187      P=0.412N     P=0.712     |P=0.461      P=0.594      P=0.575      P=0.520      | 
|POLY 3             |     P=0.224N     P=0.129      P=0.484N     P=0.590N    |P=0.473      P=0.555      P=0.549      P=0.529      | 
|POLY 1.5           |     P=0.194N     P=0.129      P=0.492N     P=0.546N    |P=0.471      P=0.538      P=0.534      P=0.522      | 
|POLY 6             |     P=0.270N     P=0.132      P=0.472N     P=0.663N    |P=0.468      P=0.569      P=0.560      P=0.528      | 
|LOGISTIC REGRESSION|     P=0.227N     P=0.131      P=0.481N     P=0.498N    |P=0.465      P=0.557      P=0.558      P=0.518      | 
|COCH-ARM / FISHERS |     P=0.162N     P=0.134      P=0.500N     P=0.500N    |P=0.455      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.188N     (e)          (e)          (e)         |P=0.628      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  21/50 (42%)  35/50 (70%)  33/50 (66%) |46/50 (92%)  38/50 (76%)  29/50 (58%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     22/43.43     21/42.28     35/46.53     33/44.29    |46/49.75     38/48.53     29/47.60     30/46.57     | 
|POLY-3 PERCENT (g) |     50.7%        49.7%        75.2%        74.5%       |92.5%        78.3%        60.9%        64.4%        | 
|TERMINAL (d)       |     17/22 (77%)  18/27 (67%)  27/31 (87%)  1/2 (50%)   |31/32 (97%)  32/38 (84%)  26/37 (70%)  25/34 (74%)  | 
|FIRST INCIDENCE    |     506          543          486          488         |288          613          679          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.183N     P=0.219      P<0.001 **  |P<0.001N**   P=0.006N**   P<0.001N**   P<0.001N**   | 
|POLY 3             |     P=0.002 **   P=0.551N     P=0.009 **   P=0.011 *   |P<0.001N**   P=0.037N*    P<0.001N**   P<0.001N**   | 
|POLY 1.5           |     P=0.002 **   P=0.539N     P=0.007 **   P=0.015 *   |P<0.001N**   P=0.031N*    P<0.001N**   P<0.001N**   | 
|POLY 6             |     P<0.001 **   P=0.541N     P=0.014 *    P=0.008 **  |P<0.001N**   P=0.048N*    P<0.001N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.487N     P=0.013 *    P=0.008 **  |P<0.001N**   P=0.024N*    P<0.001N**   P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.004 **   P=0.500N     P=0.007 **   P=0.022 *   |P<0.001N**   P=0.027N*    P<0.001N**   P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.006 **   (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.76      0/41.56      0/44.30      2/32.23     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         6.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          ---          ---          694         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113      P=0.508N     P=0.504N     P=0.241     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.229      P=0.506N     P=0.493N     P=0.403     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.234      P=0.505N     P=0.497N     P=0.450     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.250      P=0.504N     P=0.486N     P=0.329     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.299      P=0.363N     P=0.599N     P=0.568     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.076      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   17/50 (34%)  22/50 (44%)  4/50 (8%)   |10/50 (20%)  11/50 (22%)  5/50 (10%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     9/42.22      17/41.69     22/44.40     4/33.20     |10/44.60     11/47.85     5/47.30      5/45.93      | 
|POLY-3 PERCENT (g) |     21.3%        40.8%        49.6%        12.1%       |22.4%        23.0%        10.6%        10.9%        | 
|TERMINAL (d)       |     8/22 (36%)   15/27 (56%)  20/31 (65%)  1/2 (50%)   |7/32 (22%)   9/38 (24%)   4/37 (11%)   4/34 (12%)   | 
|FIRST INCIDENCE    |     693          710          708          488         |624          633          709          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.129      P=0.044 *    P=0.104     |P=0.049N*    P=0.537N     P=0.090N     P=0.118N     | 
|POLY 3             |     P=0.322N     P=0.041 *    P=0.004 **   P=0.226N    |P=0.047N*    P=0.572      P=0.104N     P=0.115N     | 
|POLY 1.5           |     P=0.164N     P=0.044 *    P=0.004 **   P=0.165N    |P=0.047N*    P=0.551      P=0.111N     P=0.118N     | 
|POLY 6             |     P=0.399      P=0.040 *    P=0.005 **   P=0.366N    |P=0.048N*    P=0.586      P=0.100N     P=0.118N     | 
|LOGISTIC REGRESSION|     P=0.155      P=0.079      P=0.024 *    P=0.543N    |P=0.047N*    P=0.581      P=0.099N     P=0.115N     | 
|COCH-ARM / FISHERS |     P=0.078N     P=0.055      P=0.004 **   P=0.117N    |P=0.053N     P=0.500      P=0.131N     P=0.131N     | 
|ORDER RESTRICTED   |     P=0.011N*    (e)          (e)          (e)         |P=0.098N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  19/50 (38%)  9/50 (18%)   14/50 (28%) |12/50 (24%)  6/50 (12%)   11/50 (22%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     19/47.03     19/47.36     9/46.35      14/37.37    |12/44.54     6/48.82      11/48.44     12/47.49     | 
|POLY-3 PERCENT (g) |     40.4%        40.1%        19.4%        37.5%       |26.9%        12.3%        22.7%        25.3%        | 
|TERMINAL (d)       |     3/22 (14%)   5/27 (19%)   1/31 (3%)    1/2 (50%)   |6/32 (19%)   1/38 (3%)    3/37 (8%)    6/34 (18%)   | 
|FIRST INCIDENCE    |     425          344          494          487         |673          609          633          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320      P=0.494N     P=0.015N*    P=0.088     |P=0.359      P=0.069N     P=0.394N     P=0.549N     | 
|POLY 3             |     P=0.227N     P=0.572N     P=0.021N*    P=0.480N    |P=0.372      P=0.062N     P=0.409N     P=0.522N     | 
|POLY 1.5           |     P=0.158N     P=0.577N     P=0.021N*    P=0.332N    |P=0.369      P=0.072N     P=0.438N     P=0.542N     | 
|POLY 6             |     P=0.333N     P=0.560N     P=0.020N*    P=0.454     |P=0.369      P=0.054N     P=0.382N     P=0.510N     | 
|LOGISTIC REGRESSION|     P=0.008N**   P=0.535N     P=0.032N*    P=0.047N*   |P=0.324      P=0.091N     P=0.452N     P=0.574N     | 
|COCH-ARM / FISHERS |     P=0.093N     P=0.582N     P=0.022N*    P=0.198N    |P=0.350      P=0.096N     P=0.500N     P=0.592N     | 
|ORDER RESTRICTED   |     P=0.171N     (e)          (e)          (e)         |P=0.339N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     49/50 (98%)  46/50 (92%)  48/50 (96%)  50/50 (100%)|10/50 (20%)  35/50 (70%)  39/50 (78%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     49/49.20     46/47.43     48/49.30     50/50.00    |10/44.61     35/48.63     39/48.84     40/47.51     | 
|POLY-3 PERCENT (g) |     99.6%        97.0%        97.4%        100.0%      |22.4%        72.0%        79.9%        84.2%        | 
|TERMINAL (d)       |     22/22 (100%) 27/27 (100%) 30/31 (97%)  2/2 (100%)  |7/32 (22%)   29/38 (76%)  31/37 (84%)  31/34 (91%)  | 
|FIRST INCIDENCE    |     495          499          494          487         |634          613          609          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.130N     P=0.037N*    P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.475      P=0.394N     P=0.464N     P=1.000     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.336      P=0.272N     P=0.468N     P=0.891     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.599      P=0.545N     P=0.481N     P=1.000     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.124      P=0.346N     P=0.419N     (e)         |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.199      P=0.181N     P=0.500N     P=0.500     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.257      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    17/50 (34%)  31/50 (62%)  19/50 (38%) |0/50 (0%)    27/50 (54%)  30/50 (60%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     0/42.08      17/42.38     31/45.76     19/39.17    |0/44.12      27/47.63     30/47.47     33/46.27     | 
|POLY-3 PERCENT (g) |     0.0%         40.1%        67.8%        48.5%       |0.0%         56.7%        63.2%        71.3%        | 
|TERMINAL (d)       |     0/22 (0%)    13/27 (48%)  27/31 (87%)  0/2 (0%)    |0/32 (0%)    25/38 (66%)  29/37 (78%)  30/34 (88%)  | 
|FIRST INCIDENCE    |     ---          543          486          487         |---          697          662          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      3/46.80      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         6.4%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.013 *    (e)          (e)          P=0.138      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.011 *    (e)          (e)          P=0.130      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.011 *    (e)          (e)          P=0.127      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.011 *    (e)          (e)          P=0.131      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.004 **   (e)          (e)          P=0.059      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.012 *    (e)          (e)          P=0.121      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.010 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    5/50 (10%)   7/50 (14%)  |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.24      2/41.90      5/44.48      7/34.41     |0/44.12      2/47.49      1/47.33      0/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         4.8%         11.2%        20.3%       |0.0%         4.2%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    2/38 (5%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     709          373          708          540         |---          729 (T)      701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.656N     P=0.352      P=0.002 **  |P=0.460N     P=0.277      P=0.515      (e)          | 
|POLY 3             |     P=0.011 *    P=0.692      P=0.237      P=0.038 *   |P=0.442N     P=0.254      P=0.514      (e)          | 
|POLY 1.5           |     P=0.017 *    P=0.688      P=0.227      P=0.055     |P=0.446N     P=0.249      P=0.510      (e)          | 
|POLY 6             |     P=0.006 **   P=0.690N     P=0.255      P=0.019 *   |P=0.442N     P=0.258      P=0.517      (e)          | 
|LOGISTIC REGRESSION|     P=0.036 *    P=0.671N     P=0.268      P=0.077     |P=0.457N     P=0.277      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.027 *    P=0.684      P=0.218      P=0.080     |P=0.461N     P=0.247      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.017 *    (e)          (e)          (e)         |P=0.332N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/49 (8%)    5/50 (10%)   2/50 (4%)   |12/50 (24%)  5/50 (10%)   9/50 (18%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/42.28      4/41.60      5/44.99      2/33.09     |12/45.47     5/47.62      9/48.03      7/46.53      | 
|POLY-3 PERCENT (g) |     4.7%         9.6%         11.1%        6.0%        |26.4%        10.5%        18.7%        15.1%        | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    4/31 (13%)   0/2 (0%)    |8/32 (25%)   4/38 (11%)   5/37 (14%)   4/34 (12%)   | 
|FIRST INCIDENCE    |     676          609          494          529         |543          697          528          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209      P=0.377      P=0.333      P=0.402     |P=0.226N     P=0.031N*    P=0.224N     P=0.137N     | 
|POLY 3             |     P=0.456      P=0.329      P=0.241      P=0.603     |P=0.225N     P=0.041N*    P=0.262N     P=0.138N     | 
|POLY 1.5           |     P=0.545      P=0.325      P=0.230      P=0.649     |P=0.224N     P=0.044N*    P=0.275N     P=0.139N     | 
|POLY 6             |     P=0.326      P=0.341      P=0.260      P=0.518     |P=0.230N     P=0.041N*    P=0.258N     P=0.143N     | 
|LOGISTIC REGRESSION|     P=0.513N     P=0.324      P=0.216      P=0.633N    |P=0.236N     P=0.049N*    P=0.319N     P=0.151N     | 
|COCH-ARM / FISHERS |     P=0.515N     P=0.329      P=0.218      P=0.691N    |P=0.230N     P=0.054N     P=0.312N     P=0.154N     | 
|ORDER RESTRICTED   |     P=0.398      (e)          (e)          (e)         |P=0.110N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    10/50 (20%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/40.97      2/44.31      10/35.76    |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         28.0%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          726          488         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.316      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P=0.249      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.243      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P=0.259      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.300      P=0.004 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.247      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  5/49 (10%)   13/50 (26%)  7/50 (14%)  |18/50 (36%)  18/50 (36%)  13/50 (26%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     16/43.76     5/41.05      13/45.19     7/34.87     |18/45.45     18/47.79     13/47.53     15/46.44     | 
|POLY-3 PERCENT (g) |     36.6%        12.2%        28.8%        20.1%       |39.6%        37.7%        27.4%        32.3%        | 
|TERMINAL (d)       |     10/22 (46%)  4/27 (15%)   7/31 (23%)   0/2 (0%)    |13/32 (41%)  14/38 (37%)  12/37 (32%)  13/34 (38%)  | 
|FIRST INCIDENCE    |     495          709          590          488         |543          693          644          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.245      P=0.002N**   P=0.105N     P=0.238     |P=0.220N     P=0.358N     P=0.097N     P=0.270N     | 
|POLY 3             |     P=0.163N     P=0.007N**   P=0.287N     P=0.084N    |P=0.221N     P=0.508N     P=0.149N     P=0.304N     | 
|POLY 1.5           |     P=0.115N     P=0.007N**   P=0.309N     P=0.049N*   |P=0.221N     P=0.526N     P=0.160N     P=0.306N     | 
|POLY 6             |     P=0.252N     P=0.006N**   P=0.245N     P=0.189N    |P=0.233N     P=0.504N     P=0.147N     P=0.317N     | 
|LOGISTIC REGRESSION|     P=0.180N     P=0.007N**   P=0.278N     P=0.062N    |P=0.214N     P=0.476N     P=0.142N     P=0.292N     | 
|COCH-ARM / FISHERS |     P=0.080N     P=0.007N**   P=0.330N     P=0.028N*   |P=0.236N     P=0.582N     P=0.194N     P=0.335N     | 
|ORDER RESTRICTED   |     P=0.071N     (e)          (e)          (e)         |P=0.257N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/50 (92%)  47/49 (96%)  49/50 (98%)  50/50 (100%)|50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%) | 
|POLY-3 RATE (b)    |     46/48.55     47/47.72     49/49.31     50/50.00    |50/50.00     50/50.00     50/50.00     50/50.00     | 
|POLY-3 PERCENT (g) |     94.8%        98.5%        99.4%        100.0%      |100.0%       100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     22/22 (100%) 27/27 (100%) 31/31 (100%) 2/2 (100%)  |32/32 (100%) 38/38 (100%) 37/37 (100%) 34/34 (100%) | 
|FIRST INCIDENCE    |     425          344          486          487         |288          609          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.289N     P=0.103N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.032 *    P=0.286      P=0.176      P=0.113     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.027 *    P=0.304      P=0.166      P=0.081     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.072      P=0.317      P=0.250      P=0.215     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.014 *    P=0.246      P=0.214      P=0.028 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.029 *    P=0.349      P=0.181      P=0.059     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.007 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.13      3/40.97      0/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         7.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    3/27 (11%)   0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     715          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.345N     P=0.376      P=0.451N     P=0.898N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.175N     P=0.295      P=0.490N     P=0.554N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.165N     P=0.294      P=0.495N     P=0.528N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.192N     P=0.301      P=0.482N     P=0.598N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.306N     P=0.342      P=0.477N     P=0.755N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.301      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.163N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      2/41.11      0/44.30      0/32.01     |0/44.12      0/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         4.9%         0.0%         0.0%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          709          ---          ---         |---          ---          728          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.688N     P=0.272      (e)          (e)         |P=0.701      (e)          P=0.534      (e)          | 
|POLY 3             |     P=0.429N     P=0.232      (e)          (e)         |P=0.698      (e)          P=0.514      (e)          | 
|POLY 1.5           |     P=0.420N     P=0.231      (e)          (e)         |P=0.698      (e)          P=0.510      (e)          | 
|POLY 6             |     P=0.452N     P=0.237      (e)          (e)         |P=0.693      (e)          P=0.516      (e)          | 
|LOGISTIC REGRESSION|     P=0.534N     P=0.237      (e)          (e)         |P=0.693      (e)          P=0.515      (e)          | 
|COCH-ARM / FISHERS |     P=0.403N     P=0.242      (e)          (e)         |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.301N     (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.08      0/41.56      0/44.30      6/33.67     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         17.8%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          488         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.459N     P=0.432N     P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.002 **   P=0.502N     P=0.490N     P=0.027 *   |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.002 **   P=0.503N     P=0.495N     P=0.039 *   |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.002 **   P=0.499N     P=0.481N     P=0.013 *   |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.003 **   (e)          (e)          P=0.034 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.003 **   P=0.500N     P=0.500N     P=0.056     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    5/50 (10%)   4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/42.78      2/41.56      5/44.30      4/33.46     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     9.4%         4.8%         11.3%        12.0%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/22 (9%)    2/27 (7%)    5/31 (16%)   0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          729 (T)      729 (T)      549         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035 *    P=0.272N     P=0.595N     P=0.135     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.310      P=0.350N     P=0.522      P=0.503     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.372      P=0.348N     P=0.511      P=0.572     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.231      P=0.345N     P=0.544      P=0.388     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.330      P=0.341N     P=0.529      P=0.624N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.446      P=0.339N     P=0.500      P=0.643N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.389      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  41/50 (82%)  48/50 (96%)  46/50 (92%) |50/50 (100%) 49/50 (98%)  48/50 (96%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     47/48.80     41/45.20     48/49.75     46/48.63    |50/50.00     49/50.00     48/49.66     49/49.81     | 
|POLY-3 PERCENT (g) |     96.3%        90.7%        96.5%        94.6%       |100.0%       98.0%        96.7%        98.4%        | 
|TERMINAL (d)       |     22/22 (100%) 27/27 (100%) 31/31 (100%) 1/2 (50%)   |32/32 (100%) 37/38 (97%)  36/37 (97%)  34/34 (100%) | 
|FIRST INCIDENCE    |     425          499          486          487         |288          609          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.043N*    P=0.063N     P<0.001 **  |P=0.424N     P=0.096N     P=0.103N     P=0.340N     | 
|POLY 3             |     P=0.600N     P=0.198N     P=0.711      P=0.538N    |P=0.424N     P=0.500N     P=0.289N     P=0.593N     | 
|POLY 1.5           |     P=0.521      P=0.120N     P=0.619      P=0.515N    |P=0.395N     P=0.500N     P=0.262N     P=0.544N     | 
|POLY 6             |     P=0.552N     P=0.350N     P=0.700N     P=0.582N    |P=0.484N     P=0.500N     P=0.343N     P=0.701N     | 
|LOGISTIC REGRESSION|     P=0.167      P=0.084N     P=0.542      P=0.652     |P=0.353N     (e)          P=0.209N     P=0.489N     | 
|COCH-ARM / FISHERS |     P=0.401      P=0.061N     P=0.500      P=0.500N    |P=0.366N     P=0.500N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.438N     (e)          (e)          (e)         |P=0.252N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |0/44.12      1/47.57      1/47.22      2/46.27      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.1%         2.1%         4.3%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          710          729 (T)      581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.151      P=0.520      P=0.529      P=0.253      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.162      P=0.515      P=0.514      P=0.248      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.160      P=0.510      P=0.510      P=0.245      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.162      P=0.518      P=0.516      P=0.248      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.140      P=0.509      P=0.529      P=0.196      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.127      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/19 (11%)   0/20 (0%)    0/16 (0%)    1/19 (5%)   |1/8 (13%)    0/8 (0%)     0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     2/15.00      0/13.24      0/14.06      1/11.59     |1/6.66       0/7.07       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     13.3%        0.0%         0.0%         8.6%        |15.0%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     0/8 (0%)     0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     715          ---          ---          569         |624          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.680N     P=0.206N     P=0.178N     P=0.612     |P=0.298N     P=0.487N     P=0.483N     P=0.487N     | 
|POLY 3             |     P=0.410N     P=0.260N     P=0.245N     P=0.591N    |P=0.259N     P=0.488N     P=0.428N     P=0.410N     | 
|POLY 1.5           |     P=0.440N     P=0.246N     P=0.259N     P=0.549N    |P=0.257N     P=0.491N     P=0.429N     P=0.411N     | 
|POLY 6             |     P=0.356N     P=0.269N     P=0.221N     P=0.655N    |P=0.256N     P=0.487N     P=0.431N     P=0.414N     | 
|LOGISTIC REGRESSION|     P=0.527N     P=0.222N     P=0.122N     P=0.685N    |P=0.321N     P=0.590N     P=0.518N     P=0.517N     | 
|COCH-ARM / FISHERS |     P=0.471N     P=0.231N     P=0.287N     P=0.500N    |P=0.250N     P=0.500N     P=0.421N     P=0.400N     | 
|ORDER RESTRICTED   |     P=0.186N     (e)          (e)          (e)         |P=0.065N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    0/20 (0%)    0/16 (0%)    0/19 (0%)   |3/8 (38%)    0/8 (0%)     0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     0/14.93      0/13.24      0/14.06      0/11.07     |3/6.76       0/7.07       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |44.4%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     0/8 (0%)     0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |624          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.047N*    P=0.110N     P=0.113N     P=0.123N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.010N*    P=0.069N     P=0.034N*    P=0.026N*    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.011N*    P=0.074N     P=0.036N*    P=0.028N*    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.009N**   P=0.067N     P=0.034N*    P=0.027N*    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.022N*    P=0.088N     P=0.050N     P=0.041N*    | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.023N*    P=0.100N     P=0.058N     P=0.049N*    | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/19 (5%)    2/20 (10%)   0/16 (0%)    2/19 (11%)  |3/8 (38%)    0/8 (0%)     0/11 (0%)    2/12 (17%)   | 
|POLY-3 RATE (b)    |     1/14.99      2/13.32      0/14.06      2/12.03     |3/6.47       0/7.07       0/9.49       2/10.84      | 
|POLY-3 PERCENT (g) |     6.7%         15.0%        0.0%         16.6%       |46.4%        0.0%         0.0%         18.5%        | 
|TERMINAL (d)       |     0/3 (0%)     1/4 (25%)    0/8 (0%)     0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     715          709          ---          569         |708          ---          ---          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.216      P=0.567      P=0.443N     P=0.262     |P=0.541N     P=0.110N     P=0.115N     P=0.504N     | 
|POLY 3             |     P=0.414      P=0.457      P=0.513N     P=0.421     |P=0.383N     P=0.061N     P=0.029N*    P=0.246N     | 
|POLY 1.5           |     P=0.430      P=0.478      P=0.523N     P=0.457     |P=0.378N     P=0.069N     P=0.033N*    P=0.266N     | 
|POLY 6             |     P=0.406      P=0.443      P=0.493N     P=0.370     |P=0.383N     P=0.053N     P=0.026N*    P=0.228N     | 
|LOGISTIC REGRESSION|     P=0.394      P=0.487      P=0.434N     P=0.528     |P=0.359N     P=0.053N     P=0.032N*    P=0.254N     | 
|COCH-ARM / FISHERS |     P=0.457      P=0.520      P=0.543N     P=0.500     |P=0.375N     P=0.100N     P=0.058N     P=0.296N     | 
|ORDER RESTRICTED   |     P=0.300      (e)          (e)          (e)         |P=0.018N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/19 (16%)   0/20 (0%)    4/16 (25%)   3/19 (16%)  |0/8 (0%)     0/8 (0%)     0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     3/15.48      0/13.24      4/14.06      3/12.03     |0/6.28       0/7.07       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     19.4%        0.0%         28.5%        24.9%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/3 (33%)    0/4 (0%)     4/8 (50%)    0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     634          ---          729 (T)      488         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049 *    P=0.114N     P=0.438N     P=0.151     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.259      P=0.136N     P=0.443      P=0.546     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.305      P=0.123N     P=0.422      P=0.605     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.197      P=0.150N     P=0.483      P=0.446     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.186      P=0.136N     P=0.590      P=0.557     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.349      P=0.106N     P=0.398      P=0.670N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.209      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/19 (5%)    0/20 (0%)    1/16 (6%)    2/19 (11%)  |0/8 (0%)     0/8 (0%)     0/11 (0%)    2/12 (17%)   | 
|POLY-3 RATE (b)    |     1/15.27      0/13.24      1/14.06      2/11.99     |0/6.28       0/7.07       0/9.49       2/10.67      | 
|POLY-3 PERCENT (g) |     6.6%         0.0%         7.1%         16.7%       |0.0%         0.0%         0.0%         18.8%        | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     1/8 (13%)    0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     634          ---          729 (T)      549         |---          ---          ---          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113      P=0.515N     P=0.658N     P=0.348     |P=0.046 *    (e)          (e)          P=0.258      | 
|POLY 3             |     P=0.206      P=0.529N     P=0.744      P=0.413     |P=0.075      (e)          (e)          P=0.357      | 
|POLY 1.5           |     P=0.223      P=0.515N     P=0.733      P=0.453     |P=0.074      (e)          (e)          P=0.346      | 
|POLY 6             |     P=0.189      P=0.541N     P=0.764N     P=0.356     |P=0.075      (e)          (e)          P=0.369      | 
|LOGISTIC REGRESSION|     P=0.243      P=0.480N     P=0.736      P=0.655     |P=0.074      (e)          (e)          P=0.342      | 
|COCH-ARM / FISHERS |     P=0.238      P=0.487N     P=0.713      P=0.500     |P=0.074      (e)          (e)          P=0.347      | 
|ORDER RESTRICTED   |     P=0.153      (e)          (e)          (e)         |P=0.099      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    0/20 (0%)    1/16 (6%)    2/19 (11%)  |0/8 (0%)     0/8 (0%)     0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     0/14.93      0/13.24      1/14.06      2/12.26     |0/6.28       0/7.07       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.1%         16.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     1/8 (13%)    0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      507         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    (e)          P=0.695      P=0.226     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.051      (e)          P=0.488      P=0.187     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.059      (e)          P=0.477      P=0.207     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.042 *    (e)          P=0.509      P=0.158     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.087      (e)          P=0.695      P=0.605     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.067      (e)          P=0.457      P=0.243     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.045 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/19 (11%)   0/20 (0%)    0/16 (0%)    0/19 (0%)   |0/8 (0%)     0/8 (0%)     1/11 (9%)    1/12 (8%)    | 
|POLY-3 RATE (b)    |     2/15.72      0/13.24      0/14.06      0/11.07     |0/6.28       0/7.07       1/9.49       1/10.47      | 
|POLY-3 PERCENT (g) |     12.7%        0.0%         0.0%         0.0%        |0.0%         0.0%         10.5%        9.6%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     0/8 (0%)     0/0 (0%)    |0/0 (0%)     0/3 (0%)     1/4 (25%)    0/3 (0%)     | 
|FIRST INCIDENCE    |     584          ---          ---          ---         |---          ---          729 (T)      709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.143N     P=0.248N     P=0.232N     P=0.363N    |P=0.303      (e)          P=1.000      P=0.500      | 
|POLY 3             |     P=0.082N     P=0.272N     P=0.256N     P=0.318N    |P=0.339      (e)          P=0.581      P=0.600      | 
|POLY 1.5           |     P=0.098N     P=0.253N     P=0.265N     P=0.276N    |P=0.333      (e)          P=0.575      P=0.593      | 
|POLY 6             |     P=0.073N     P=0.292N     P=0.241N     P=0.391N    |P=0.342      (e)          P=0.588      P=0.607      | 
|LOGISTIC REGRESSION|     P=0.107N     P=0.170N     P=0.334N     P=0.144N    |P=0.312      (e)          P=1.000      P=0.612      | 
|COCH-ARM / FISHERS |     P=0.120N     P=0.231N     P=0.287N     P=0.243N    |P=0.314      (e)          P=0.579      P=0.600      | 
|ORDER RESTRICTED   |     P=0.068N     (e)          (e)          (e)         |P=0.352      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    1/20 (5%)    2/16 (13%)   3/19 (16%)  |2/8 (25%)    1/8 (13%)    4/11 (36%)   2/12 (17%)   | 
|POLY-3 RATE (b)    |     0/14.93      1/13.36      2/14.23      3/12.26     |2/7.21       1/7.22       4/9.85       2/10.48      | 
|POLY-3 PERCENT (g) |     0.0%         7.5%         14.1%        24.5%       |27.8%        13.9%        40.6%        19.1%        | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     0/8 (0%)     0/0 (0%)    |0/0 (0%)     0/3 (0%)     1/4 (25%)    0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          698          708          537         |430          690          662          709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.532      P=0.303      P=0.044 *   |P=0.519      P=0.477N     P=0.538      P=0.689N     | 
|POLY 3             |     P=0.033 *    P=0.478      P=0.219      P=0.072     |P=0.519N     P=0.499N     P=0.486      P=0.558N     | 
|POLY 1.5           |     P=0.042 *    P=0.488      P=0.206      P=0.088     |P=0.509N     P=0.500N     P=0.487      P=0.551N     | 
|POLY 6             |     P=0.025 *    P=0.472      P=0.246      P=0.054     |P=0.540N     P=0.495N     P=0.489      P=0.571N     | 
|LOGISTIC REGRESSION|     P=0.037 *    P=0.470      P=0.257      P=0.141     |P=0.549N     P=0.706N     P=0.413      P=0.695N     | 
|COCH-ARM / FISHERS |     P=0.055      P=0.513      P=0.202      P=0.115     |P=0.500N     P=0.500N     P=0.494      P=0.535N     | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.516N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    0/20 (0%)    2/16 (13%)   2/19 (11%)  |0/8 (0%)     0/8 (0%)     0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     0/14.93      0/13.24      2/14.06      2/11.59     |0/6.28       0/7.07       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         14.2%        17.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     2/8 (25%)    0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      604         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   (e)          P=0.470      P=0.069     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.046 *    (e)          P=0.216      P=0.175     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.060      (e)          P=0.205      P=0.201     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.031 *    (e)          P=0.239      P=0.142     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.024 *    (e)          P=0.470      P=0.147     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.081      (e)          P=0.202      P=0.243     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.072      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    0/20 (0%)    1/16 (6%)    1/19 (5%)   |0/8 (0%)     2/8 (25%)    0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     0/14.93      0/13.24      1/14.06      1/11.41     |0/6.28       2/7.09       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.1%         8.8%        |0.0%         28.2%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     1/8 (13%)    0/0 (0%)    |0/0 (0%)     1/3 (33%)    0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      634         |---          725          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.078      (e)          P=0.695      P=0.380     |P=0.283N     P=0.539      (e)          (e)          | 
|POLY 3             |     P=0.167      (e)          P=0.488      P=0.447     |P=0.263N     P=0.247      (e)          (e)          | 
|POLY 1.5           |     P=0.198      (e)          P=0.477      P=0.471     |P=0.277N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.136      (e)          P=0.509      P=0.410     |P=0.249N     P=0.258      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.158      (e)          P=0.695      P=0.502     |P=0.248N     P=0.543      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.231      (e)          P=0.457      P=0.500     |P=0.314N     P=0.233      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.200      (e)          (e)          (e)         |P=0.171N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/19 (5%)    1/20 (5%)    2/16 (13%)   0/19 (0%)   |0/8 (0%)     3/8 (38%)    0/11 (0%)    1/12 (8%)    | 
|POLY-3 RATE (b)    |     1/14.93      1/13.36      2/14.06      0/11.07     |0/6.28       3/7.09       0/9.49       1/10.57      | 
|POLY-3 PERCENT (g) |     6.7%         7.5%         14.2%        0.0%        |0.0%         42.3%        0.0%         9.5%         | 
|TERMINAL (d)       |     1/3 (33%)    0/4 (0%)     2/8 (25%)    0/0 (0%)    |0/0 (0%)     2/3 (67%)    0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      698          729 (T)      ---         |---          725          ---          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.662N     P=0.710N     P=0.678N     P=1.000N    |P=0.483N     P=0.539      (e)          P=0.500      | 
|POLY 3             |     P=0.470N     P=0.738      P=0.478      P=0.559N    |P=0.442N     P=0.100      (e)          P=0.602      | 
|POLY 1.5           |     P=0.425N     P=0.749      P=0.459      P=0.531N    |P=0.463N     P=0.095      (e)          P=0.594      | 
|POLY 6             |     P=0.559N     P=0.734      P=0.516      P=0.601N    |P=0.418N     P=0.104      (e)          P=0.610      | 
|LOGISTIC REGRESSION|     P=0.568N     P=0.757      P=0.678N     (e)         |P=0.487N     (e)          (e)          P=0.586      | 
|COCH-ARM / FISHERS |     P=0.376N     P=0.744N     P=0.434      P=0.500N    |P=0.500N     P=0.100      (e)          P=0.600      | 
|ORDER RESTRICTED   |     P=0.305N     (e)          (e)          (e)         |P=0.230N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    0/20 (0%)    3/16 (19%)   1/19 (5%)   |0/8 (0%)     0/8 (0%)     0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     0/14.93      0/13.24      3/14.47      1/11.15     |0/6.28       0/7.07       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         20.7%        9.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     2/8 (25%)    0/0 (0%)    |0/0 (0%)     0/3 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          613          708         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          P=0.244      P=0.172     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.114      (e)          P=0.099      P=0.442     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.167      (e)          P=0.089      P=0.469     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.063      (e)          P=0.121      P=0.401     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.112      (e)          P=0.092      P=0.284     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.238      (e)          P=0.086      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.104      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Pigmentation Hemosiderin                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    0/20 (0%)    0/16 (0%)    0/19 (0%)   |0/8 (0%)     2/8 (25%)    0/11 (0%)    0/12 (0%)    | 
|POLY-3 RATE (b)    |     0/14.93      0/13.24      0/14.06      0/11.07     |0/6.28       2/7.09       0/9.49       0/10.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         28.2%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/4 (0%)     0/8 (0%)     0/0 (0%)    |0/0 (0%)     1/3 (33%)    0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          725          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.283N     P=0.539      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.263N     P=0.247      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.277N     P=0.238      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.249N     P=0.258      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.248N     P=0.543      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.314N     P=0.233      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.171N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/48 (0%)    1/50 (2%)    0/50 (0%)   |7/50 (14%)   3/50 (6%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/42.61      0/39.64      1/44.40      0/32.01     |7/44.35      3/47.57      2/47.30      2/45.95      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         2.3%         0.0%        |15.8%        6.3%         4.2%         4.4%         | 
|TERMINAL (d)       |     0/22 (0%)    0/26 (0%)    0/31 (0%)    0/2 (0%)    |5/32 (16%)   2/38 (5%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     632          ---          705          ---         |673          710          709          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.288N     P=0.250N     P=0.445N     P=0.425N    |P=0.055N     P=0.111N     P=0.060N     P=0.076N     | 
|POLY 3             |     P=0.202N     P=0.253N     P=0.486N     P=0.306N    |P=0.054N     P=0.130N     P=0.064N     P=0.070N     | 
|POLY 1.5           |     P=0.196N     P=0.252N     P=0.492N     P=0.271N    |P=0.054N     P=0.138N     P=0.069N     P=0.072N     | 
|POLY 6             |     P=0.220N     P=0.252N     P=0.474N     P=0.373N    |P=0.055N     P=0.125N     P=0.062N     P=0.071N     | 
|LOGISTIC REGRESSION|     P=0.183N     P=0.237N     P=0.512N     P=0.228N    |P=0.051N     P=0.124N     P=0.063N     P=0.073N     | 
|COCH-ARM / FISHERS |     P=0.187N     P=0.258N     P=0.500N     P=0.247N    |P=0.056N     P=0.159N     P=0.080N     P=0.080N     | 
|ORDER RESTRICTED   |     P=0.124N     (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    4/50 (8%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/39.64      0/44.30      0/32.01     |3/44.28      4/47.49      1/47.22      3/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.8%         8.4%         2.1%         6.6%         | 
|TERMINAL (d)       |     0/22 (0%)    0/26 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    4/38 (11%)   1/37 (3%)    3/34 (9%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |697          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.479N     P=0.578      P=0.275N     P=0.650N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.468N     P=0.538      P=0.283N     P=0.647N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.469N     P=0.527      P=0.289N     P=0.649N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.471N     P=0.544      P=0.279N     P=0.651N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.487N     P=0.550      P=0.278N     P=0.654N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.479N     P=0.500      P=0.309N     P=0.661N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.405N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/9 (78%)    7/12 (58%)   7/8 (88%)    3/4 (75%)   |11/12 (92%)  18/18 (100%) 10/10 (100%) 4/6 (67%)    | 
|POLY-3 RATE (b)    |     7/7.74       7/10.27      7/7.92       3/3.66      |11/11.98     18/18.00     10/10.00     4/5.51       | 
|POLY-3 PERCENT (g) |     90.4%        68.2%        88.4%        82.0%       |91.8%        100.0%       100.0%       72.7%        | 
|TERMINAL (d)       |     5/5 (100%)   7/8 (88%)    4/4 (100%)   0/0 (0%)    |7/7 (100%)   13/13 (100%) 10/10 (100%) 4/5 (80%)    | 
|FIRST INCIDENCE    |     704          729 (T)      543          681         |673          690          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.025 *    P=0.134N     P=0.610      P=0.035 *   |P=0.004N**   P=0.556      P=0.060N     P=0.033N*    | 
|POLY 3             |     P=0.664      P=0.261N     P=0.780N     P=0.758N    |P=0.166N     P=0.427      P=0.544      P=0.370N     | 
|POLY 1.5           |     P=0.591      P=0.284N     P=0.726      P=0.723N    |P=0.111N     P=0.422      P=0.540      P=0.314N     | 
|POLY 6             |     P=0.638N     P=0.267N     P=0.705N     P=0.891N    |P=0.265N     P=0.435      P=0.552      P=0.451N     | 
|LOGISTIC REGRESSION|     P=0.558      P=0.398N     P=0.739      (e)         |P=0.243N     P=0.422      P=0.548      P=0.430N     | 
|COCH-ARM / FISHERS |     P=0.500      P=0.324N     P=0.547      P=0.706N    |P=0.077N     P=0.400      P=0.545      P=0.245N     | 
|ORDER RESTRICTED   |     P=0.516N     (e)          (e)          (e)         |P=0.061N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   8/50 (16%)   9/50 (18%)  |2/50 (4%)    1/50 (2%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     7/44.40      7/42.91      8/44.38      9/35.61     |2/44.20      1/47.49      3/47.53      1/45.76      | 
|POLY-3 PERCENT (g) |     15.8%        16.3%        18.0%        25.3%       |4.5%         2.1%         6.3%         2.2%         | 
|TERMINAL (d)       |     1/22 (5%)    3/27 (11%)   7/31 (23%)   0/2 (0%)    |1/32 (3%)    1/38 (3%)    2/37 (5%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     425          535          708          487         |708          729 (T)      644          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.557N     P=0.521N     P=0.047 *   |P=0.469N     P=0.455N     P=0.554      P=0.492N     | 
|POLY 3             |     P=0.167      P=0.587      P=0.500      P=0.219     |P=0.472N     P=0.475N     P=0.533      P=0.488N     | 
|POLY 1.5           |     P=0.227      P=0.592      P=0.497      P=0.295     |P=0.471N     P=0.482N     P=0.523      P=0.490N     | 
|POLY 6             |     P=0.104      P=0.596      P=0.514      P=0.123     |P=0.477N     P=0.470N     P=0.540      P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.392      P=0.575N     P=0.476      P=0.525N    |P=0.468N     P=0.468N     P=0.515      P=0.492N     | 
|COCH-ARM / FISHERS |     P=0.310      P=0.613N     P=0.500      P=0.393     |P=0.474N     P=0.500N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.230      (e)          (e)          (e)         |P=0.449N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.76      2/42.74      1/44.30      0/32.01     |0/44.12      0/47.49      2/47.72      0/45.76      | 
|POLY-3 PERCENT (g) |     2.3%         4.7%         2.3%         0.0%        |0.0%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          484          729 (T)      ---         |---          ---          633          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.493      P=0.725N     P=0.504N    |P=0.593      (e)          P=0.263      (e)          | 
|POLY 3             |     P=0.309N     P=0.500      P=0.753N     P=0.557N    |P=0.600      (e)          P=0.255      (e)          | 
|POLY 1.5           |     P=0.281N     P=0.498      P=0.757N     P=0.529N    |P=0.601      (e)          P=0.249      (e)          | 
|POLY 6             |     P=0.365N     P=0.508      P=0.745N     P=0.602N    |P=0.593      (e)          P=0.260      (e)          | 
|LOGISTIC REGRESSION|     P=0.182N     P=0.668      P=0.735      P=0.511N    |P=0.552      (e)          P=0.183      (e)          | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.500      P=0.753N     P=0.500N    |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.289N     (e)          (e)          (e)         |P=0.263      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/8 (100%)   6/8 (75%)    5/5 (100%)   5/7 (71%)   |4/4 (100%)   7/8 (88%)    4/4 (100%)   4/4 (100%)   | 
|POLY-3 RATE (b)    |     8/8.00       6/8.00       5/5.00       5/6.29      |4/4.00       7/7.85       4/4.00       4/4.00       | 
|POLY-3 PERCENT (g) |     100.0%       75.0%        100.0%       79.5%       |100.0%       89.2%        100.0%       100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   4/6 (67%)    3/3 (100%)   0/0 (0%)    |1/1 (100%)   6/6 (100%)   0/0 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     634          526          687          487         |358          609          609          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.254      P=0.064N     (e)          P=0.188     |P=0.437      P=0.278N     (e)          (e)          | 
|POLY 3             |     P=0.339N     P=0.223N     (e)          P=0.308N    |P=0.658      P=0.697N     (e)          (e)          | 
|POLY 1.5           |     P=0.264N     P=0.223N     (e)          P=0.238N    |P=0.634      P=0.665N     (e)          (e)          | 
|POLY 6             |     P=0.477N     P=0.223N     (e)          P=0.511N    |P=0.710      P=0.763N     (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.140N     (e)          (e)          P=0.200N    |P=0.608      P=0.709N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.233N     (e)          P=0.200N    |P=0.619      P=0.667N     (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.157N     (e)          (e)          (e)         |P=0.502      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   13/50 (26%)  10/50 (20%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |                                                        |6/44.16      13/47.62     10/47.72     9/46.02      | 
|POLY-3 PERCENT (g) |                                                        |13.6%        27.3%        21.0%        19.6%        | 
|TERMINAL (d)       |                                                        |4/32 (13%)   12/38 (32%)  8/37 (22%)   8/34 (24%)   | 
|FIRST INCIDENCE    |                                                        |724          697          609          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.435      P=0.125      P=0.294      P=0.322      | 
|POLY 3             |                                                        |P=0.466      P=0.085      P=0.257      P=0.317      | 
|POLY 1.5           |                                                        |P=0.459      P=0.077      P=0.241      P=0.311      | 
|POLY 6             |                                                        |P=0.463      P=0.090      P=0.269      P=0.315      | 
|LOGISTIC REGRESSION|                                                        |P=0.429      P=0.091      P=0.256      P=0.296      | 
|COCH-ARM / FISHERS |                                                        |P=0.428      P=0.062      P=0.207      P=0.288      | 
|ORDER RESTRICTED   |                                                        |P=0.232      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      3/32.40     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         9.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    1/2 (50%)   |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          624         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.009 **   (e)          (e)          P=0.078     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.010 *    (e)          (e)          P=0.096     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.012 *    (e)          (e)          P=0.055     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.003 **   (e)          (e)          P=0.023 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.003 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  16/50 (32%)  6/50 (12%)   9/50 (18%)  |12/50 (24%)  3/50 (6%)    2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     14/43.45     16/43.47     6/45.45      9/35.41     |12/44.91     3/47.62      2/47.84      6/46.02      | 
|POLY-3 PERCENT (g) |     32.2%        36.8%        13.2%        25.4%       |26.7%        6.3%         4.2%         13.0%        | 
|TERMINAL (d)       |     8/22 (36%)   7/27 (26%)   3/31 (10%)   0/2 (0%)    |6/32 (19%)   2/38 (5%)    1/37 (3%)    5/34 (15%)   | 
|FIRST INCIDENCE    |     495          499          543          507         |637          697          528          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.577N     P=0.011N*    P=0.048 *   |P=0.109N     P=0.008N**   P=0.004N**   P=0.091N     | 
|POLY 3             |     P=0.105N     P=0.411      P=0.026N*    P=0.338N    |P=0.104N     P=0.007N**   P=0.002N**   P=0.083N     | 
|POLY 1.5           |     P=0.080N     P=0.403      P=0.031N*    P=0.248N    |P=0.103N     P=0.008N**   P=0.003N**   P=0.084N     | 
|POLY 6             |     P=0.142N     P=0.445      P=0.020N*    P=0.518N    |P=0.106N     P=0.007N**   P=0.002N**   P=0.087N     | 
|LOGISTIC REGRESSION|     P=0.081N     P=0.397      P=0.038N*    P=0.305N    |P=0.106N     P=0.009N**   P=0.004N**   P=0.082N     | 
|COCH-ARM / FISHERS |     P=0.058N     P=0.414      P=0.039N*    P=0.171N    |P=0.108N     P=0.011N*    P=0.004N**   P=0.096N     | 
|ORDER RESTRICTED   |     P=0.088N     (e)          (e)          (e)         |P=0.003N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  21/50 (42%)  22/50 (44%)  10/50 (20%) |17/50 (34%)  10/50 (20%)  11/50 (22%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     20/44.80     21/43.65     22/45.96     10/34.77    |17/44.84     10/47.91     11/48.17     12/47.46     | 
|POLY-3 PERCENT (g) |     44.7%        48.1%        47.9%        28.8%       |37.9%        20.9%        22.8%        25.3%        | 
|TERMINAL (d)       |     9/22 (41%)   13/27 (48%)  16/31 (52%)  0/2 (0%)    |12/32 (38%)  8/38 (21%)   7/37 (19%)   6/34 (18%)   | 
|FIRST INCIDENCE    |     425          543          499          549         |613          613          528          528          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.448N     P=0.318N     P=0.104     |P=0.240N     P=0.041N*    P=0.081N     P=0.179N     | 
|POLY 3             |     P=0.105N     P=0.454      P=0.461      P=0.105N    |P=0.207N     P=0.055N     P=0.085N     P=0.138N     | 
|POLY 1.5           |     P=0.044N*    P=0.462      P=0.441      P=0.053N    |P=0.215N     P=0.063N     P=0.098N     P=0.152N     | 
|POLY 6             |     P=0.280N     P=0.467      P=0.496      P=0.272N    |P=0.203N     P=0.051N     P=0.078N     P=0.132N     | 
|LOGISTIC REGRESSION|     P=0.099N     P=0.478      P=0.462      P=0.120N    |P=0.232N     P=0.054N     P=0.100N     P=0.169N     | 
|COCH-ARM / FISHERS |     P=0.015N*    P=0.500      P=0.420      P=0.024N*   |P=0.237N     P=0.088N     P=0.133N     P=0.189N     | 
|ORDER RESTRICTED   |     P=0.082N     (e)          (e)          (e)         |P=0.079N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/45 (2%)    19/48 (40%)  32/49 (65%) |0/47 (0%)    1/48 (2%)    0/44 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     2/41.64      1/37.46      19/43.91     32/41.22    |0/42.45      1/45.49      0/42.04      1/44.23      | 
|POLY-3 PERCENT (g) |     4.8%         2.7%         43.3%        77.6%       |0.0%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     2/22 (9%)    0/25 (0%)    13/31 (42%)  1/2 (50%)   |0/32 (0%)    1/36 (3%)    0/34 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      653          624          488         |---          729 (T)      ---          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.473N     P<0.001 **   P<0.001 **  |P=0.409      P=0.523      (e)          P=0.514      | 
|POLY 3             |     P<0.001 **   P=0.537N     P<0.001 **   P<0.001 **  |P=0.415      P=0.514      (e)          P=0.508      | 
|POLY 1.5           |     P<0.001 **   P=0.537N     P<0.001 **   P<0.001 **  |P=0.414      P=0.512      (e)          P=0.508      | 
|POLY 6             |     P<0.001 **   P=0.531N     P<0.001 **   P<0.001 **  |P=0.411      P=0.514      (e)          P=0.506      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.538N     P<0.001 **   P<0.001 **  |P=0.406      P=0.523      (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.532N     P<0.001 **   P<0.001 **  |P=0.408      P=0.505      (e)          P=0.505      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.259      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  11/50 (22%)  3/50 (6%)   |30/50 (60%)  30/50 (60%)  23/50 (46%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     4/42.51      10/42.39     11/44.67     3/32.61     |30/46.39     30/48.62     23/48.36     23/47.58     | 
|POLY-3 PERCENT (g) |     9.4%         23.6%        24.6%        9.2%        |64.7%        61.7%        47.6%        48.3%        | 
|TERMINAL (d)       |     1/22 (5%)    7/27 (26%)   10/31 (32%)  1/2 (50%)   |22/32 (69%)  23/38 (61%)  17/37 (46%)  15/34 (44%)  | 
|FIRST INCIDENCE    |     676          526          624          593         |430          613          633          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.060      P=0.135      P=0.140      P=0.181     |P=0.070N     P=0.259N     P=0.047N*    P=0.101N     | 
|POLY 3             |     P=0.523      P=0.068      P=0.052      P=0.642N    |P=0.041N*    P=0.465N     P=0.067N     P=0.078N     | 
|POLY 1.5           |     P=0.429N     P=0.069      P=0.048 *    P=0.573N    |P=0.045N*    P=0.499N     P=0.079N     P=0.087N     | 
|POLY 6             |     P=0.293      P=0.071      P=0.060      P=0.544     |P=0.038N*    P=0.436N     P=0.056N     P=0.071N     | 
|LOGISTIC REGRESSION|     P=0.412      P=0.071      P=0.068      P=0.545     |P=0.046N*    P=0.456N     P=0.075N     P=0.089N     | 
|COCH-ARM / FISHERS |     P=0.291N     P=0.074      P=0.045 *    P=0.500N    |P=0.057N     P=0.581N     P=0.115N     P=0.115N     | 
|ORDER RESTRICTED   |     P=0.190      (e)          (e)          (e)         |P=0.074N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    1/50 (2%)    5/50 (10%)  |2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/42.65      3/41.56      1/44.30      5/34.41     |2/45.00      1/47.49      1/47.22      2/46.38      | 
|POLY-3 PERCENT (g) |     14.1%        7.2%         2.3%         14.5%       |4.4%         2.1%         2.1%         4.3%         | 
|TERMINAL (d)       |     2/22 (9%)    3/27 (11%)   1/31 (3%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     645          729 (T)      729 (T)      488         |358          729 (T)      729 (T)      528          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210      P=0.181N     P=0.028N*    P=0.168     |P=0.563      P=0.458N     P=0.464N     P=0.676N     | 
|POLY 3             |     P=0.514N     P=0.253N     P=0.049N*    P=0.606     |P=0.558      P=0.481N     P=0.483N     P=0.683N     | 
|POLY 1.5           |     P=0.503N     P=0.251N     P=0.053N     P=0.576N    |P=0.558      P=0.487N     P=0.488N     P=0.685N     | 
|POLY 6             |     P=0.505N     P=0.250N     P=0.044N*    P=0.474     |P=0.556      P=0.477N     P=0.480N     P=0.684N     | 
|LOGISTIC REGRESSION|     P=0.484N     P=0.234N     P=0.047N*    P=0.457N    |P=0.420      P=0.705N     P=0.688N     P=0.531      | 
|COCH-ARM / FISHERS |     P=0.482N     P=0.243N     P=0.056N     P=0.500N    |P=0.556      P=0.500N     P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.256      (e)          (e)          (e)         |P=0.525N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  21/50 (42%)  12/50 (24%)  13/50 (26%) |23/50 (46%)  24/50 (48%)  20/50 (40%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     16/44.21     21/42.91     12/45.76     13/34.80    |23/45.99     24/48.27     20/48.01     18/47.22     | 
|POLY-3 PERCENT (g) |     36.2%        48.9%        26.2%        37.4%       |50.0%        49.7%        41.7%        38.1%        | 
|TERMINAL (d)       |     10/22 (46%)  16/27 (59%)  7/31 (23%)   1/2 (50%)   |16/32 (50%)  19/38 (50%)  16/37 (43%)  13/34 (38%)  | 
|FIRST INCIDENCE    |     506          543          543          593         |528          609          633          581          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023 *    P=0.389      P=0.085N     P=0.002 **  |P=0.129N     P=0.389N     P=0.189N     P=0.171N     | 
|POLY 3             |     P=0.325N     P=0.156      P=0.212N     P=0.552     |P=0.107N     P=0.571N     P=0.272N     P=0.170N     | 
|POLY 1.5           |     P=0.229N     P=0.169      P=0.231N     P=0.485N    |P=0.110N     P=0.571      P=0.288N     P=0.176N     | 
|POLY 6             |     P=0.461N     P=0.152      P=0.180N     P=0.312     |P=0.111N     P=0.568N     P=0.269N     P=0.174N     | 
|LOGISTIC REGRESSION|     P=0.439N     P=0.185      P=0.243N     P=0.383     |P=0.110N     P=0.553N     P=0.265N     P=0.178N     | 
|COCH-ARM / FISHERS |     P=0.139N     P=0.204      P=0.252N     P=0.330N    |P=0.128N     P=0.500      P=0.343N     P=0.208N     | 
|ORDER RESTRICTED   |     P=0.239N     (e)          (e)          (e)         |P=0.194N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    1/49 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/43.08      2/41.56      1/44.30      1/32.00     |                                                    | 
|POLY-3 PERCENT (g) |     4.6%         4.8%         2.3%         3.1%        |                                                    | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    1/31 (3%)    0/2 (0%)    |                                                    | 
|FIRST INCIDENCE    |     506          729 (T)      729 (T)      529         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560N     P=0.667N     P=0.463N     P=0.563N    |                                                    | 
|POLY 3             |     P=0.393N     P=0.681      P=0.490N     P=0.601N    |                                                    | 
|POLY 1.5           |     P=0.373N     P=0.684      P=0.495N     P=0.556N    |                                                    | 
|POLY 6             |     P=0.418N     P=0.682      P=0.480N     P=0.674N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.286N     P=0.680N     P=0.542N     P=0.329N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.344N     P=0.691N     P=0.500N     P=0.508N    |                                                    | 
|ORDER RESTRICTED   |     P=0.515N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/50 (14%)   8/50 (16%)   4/50 (8%)   |                                                    | 
|POLY-3 RATE (b)    |     4/42.62      7/41.84      8/44.30      4/32.97     |                                                    | 
|POLY-3 PERCENT (g) |     9.4%         16.7%        18.1%        12.1%       |                                                    | 
|TERMINAL (d)       |     1/22 (5%)    4/27 (15%)   8/31 (26%)   1/2 (50%)   |                                                    | 
|FIRST INCIDENCE    |     632          698          729 (T)      537         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    P=0.352      P=0.353      P=0.084     |                                                    | 
|POLY 3             |     P=0.401      P=0.248      P=0.194      P=0.497     |                                                    | 
|POLY 1.5           |     P=0.513      P=0.251      P=0.186      P=0.570     |                                                    | 
|POLY 6             |     P=0.246      P=0.252      P=0.208      P=0.369     |                                                    | 
|LOGISTIC REGRESSION|     P=0.236      P=0.261      P=0.239      P=0.480     |                                                    | 
|COCH-ARM / FISHERS |     P=0.485N     P=0.262      P=0.178      P=0.643N    |                                                    | 
|ORDER RESTRICTED   |     P=0.349      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 51      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    4/50 (8%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/42.09      3/41.56      4/44.38      0/32.01     |                                                    | 
|POLY-3 PERCENT (g) |     4.8%         7.2%         9.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/22 (5%)    3/27 (11%)   3/31 (10%)   0/2 (0%)    |                                                    | 
|FIRST INCIDENCE    |     725          729 (T)      708          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.616      P=0.585      P=0.496      P=0.767N    |                                                    | 
|POLY 3             |     P=0.320N     P=0.494      P=0.362      P=0.303N    |                                                    | 
|POLY 1.5           |     P=0.254N     P=0.494      P=0.350      P=0.269N    |                                                    | 
|POLY 6             |     P=0.450N     P=0.501      P=0.382      P=0.367N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.606N     P=0.568      P=0.448      P=0.701N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.500      P=0.339      P=0.247N    |                                                    | 
|ORDER RESTRICTED   |     P=0.169N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  17/50 (34%)  26/50 (52%)  26/50 (52%) |                                                    | 
|POLY-3 RATE (b)    |     18/45.27     17/43.38     26/47.66     26/40.41    |                                                    | 
|POLY-3 PERCENT (g) |     39.8%        39.2%        54.6%        64.3%       |                                                    | 
|TERMINAL (d)       |     6/22 (27%)   9/27 (33%)   15/31 (48%)  2/2 (100%)  |                                                    | 
|FIRST INCIDENCE    |     495          484          486          487         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.349N     P=0.390      P<0.001 **  |                                                    | 
|POLY 3             |     P=0.005 **   P=0.565N     P=0.107      P=0.014 *   |                                                    | 
|POLY 1.5           |     P=0.011 *    P=0.546N     P=0.093      P=0.034 *   |                                                    | 
|POLY 6             |     P<0.001 **   P=0.571N     P=0.134      P=0.003 **  |                                                    | 
|LOGISTIC REGRESSION|     P=0.016 *    P=0.512N     P=0.071      P=0.065     |                                                    | 
|COCH-ARM / FISHERS |     P=0.028 *    P=0.500N     P=0.079      P=0.079     |                                                    | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 52      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    3/50 (6%)    0/49 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.64      1/41.88      3/44.38      0/31.45     |2/44.12      0/47.49      1/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         2.4%         6.8%         0.0%        |4.5%         0.0%         2.1%         2.2%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |2/32 (6%)    0/38 (0%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      641          708          ---         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.549      P=0.741N     P=0.432      P=0.934N    |P=0.495N     P=0.201N     P=0.449N     P=0.479N     | 
|POLY 3             |     P=0.540N     P=0.760N     P=0.328      P=0.555N    |P=0.507N     P=0.221N     P=0.476N     P=0.487N     | 
|POLY 1.5           |     P=0.476N     P=0.759N     P=0.321      P=0.528N    |P=0.504N     P=0.226N     P=0.483N     P=0.490N     | 
|POLY 6             |     P=0.516      P=0.756N     P=0.343      P=0.599N    |P=0.510N     P=0.218N     P=0.472N     P=0.489N     | 
|LOGISTIC REGRESSION|     P=0.592N     P=0.760N     P=0.382      (e)         |P=0.495N     (e)          P=0.449N     P=0.479N     | 
|COCH-ARM / FISHERS |     P=0.410N     P=0.747N     P=0.316      P=0.500N    |P=0.500N     P=0.247N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.296N     (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.64      2/41.56      0/44.30      0/31.45     |0/44.12      0/47.49      1/47.41      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         0.0%         0.0%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          679          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.689N     P=0.284      (e)          (e)         |P=0.702      (e)          P=0.523      (e)          | 
|POLY 3             |     P=0.433N     P=0.236      (e)          (e)         |P=0.698      (e)          P=0.514      (e)          | 
|POLY 1.5           |     P=0.424N     P=0.237      (e)          (e)         |P=0.698      (e)          P=0.510      (e)          | 
|POLY 6             |     P=0.457N     P=0.238      (e)          (e)         |P=0.693      (e)          P=0.518      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.284      (e)          (e)         |P=0.680      (e)          P=0.478      (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.253      (e)          (e)         |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.306N     (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 53      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    7/50 (14%)   8/50 (16%)   4/49 (8%)   |                                                    | 
|POLY-3 RATE (b)    |     3/42.52      7/41.84      8/44.30      4/32.54     |                                                    | 
|POLY-3 PERCENT (g) |     7.1%         16.7%        18.1%        12.3%       |                                                    | 
|TERMINAL (d)       |     1/22 (5%)    4/27 (15%)   8/31 (26%)   1/2 (50%)   |                                                    | 
|FIRST INCIDENCE    |     632          698          729 (T)      537         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.230      P=0.222      P=0.046 *   |                                                    | 
|POLY 3             |     P=0.294      P=0.148      P=0.110      P=0.357     |                                                    | 
|POLY 1.5           |     P=0.397      P=0.150      P=0.105      P=0.421     |                                                    | 
|POLY 6             |     P=0.163      P=0.152      P=0.120      P=0.255     |                                                    | 
|LOGISTIC REGRESSION|     P=0.155      P=0.158      P=0.143      P=0.364     |                                                    | 
|COCH-ARM / FISHERS |     P=0.516      P=0.159      P=0.100      P=0.489     |                                                    | 
|ORDER RESTRICTED   |     P=0.224      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    4/49 (8%)   |                                                    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      4/32.68     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         12.2%       |                                                    | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          621         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.008 **  |                                                    | 
|POLY 3             |     P=0.002 **   (e)          (e)          P=0.034 *   |                                                    | 
|POLY 1.5           |     P=0.002 **   (e)          (e)          P=0.044 *   |                                                    | 
|POLY 6             |     P=0.002 **   (e)          (e)          P=0.021 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.004 **   (e)          (e)          P=0.044 *   |                                                    | 
|COCH-ARM / FISHERS |     P=0.003 **   (e)          (e)          P=0.056     |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 54      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.13      0/41.56      0/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     4.8%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     715          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.151N     P=0.202N     P=0.178N     P=0.772N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.095N     P=0.240N     P=0.226N     P=0.303N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.105N     P=0.240N     P=0.231N     P=0.269N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.080N     P=0.236N     P=0.217N     P=0.367N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.146N     P=0.221N     P=0.195N     P=0.603N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.061N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.08      0/41.56      3/44.30      1/32.26     |1/44.06      0/47.49      0/47.22      1/45.95      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         6.8%         3.1%        |2.3%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    3/31 (10%)   0/2 (0%)    |1/32 (3%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      662         |729 (T)      ---          ---          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.090      P=0.459N     P=0.433      P=0.396     |P=0.597      P=0.466N     P=0.471N     P=0.751N     | 
|POLY 3             |     P=0.327      P=0.502N     P=0.324      P=0.698     |P=0.594      P=0.485N     P=0.486N     P=0.751N     | 
|POLY 1.5           |     P=0.396      P=0.503N     P=0.315      P=0.730     |P=0.595      P=0.489N     P=0.489N     P=0.752N     | 
|POLY 6             |     P=0.233      P=0.499N     P=0.339      P=0.638     |P=0.592      P=0.482N     P=0.484N     P=0.752N     | 
|LOGISTIC REGRESSION|     P=0.209      (e)          P=0.433      P=0.624     |P=0.597      (e)          (e)          P=0.756N     | 
|COCH-ARM / FISHERS |     P=0.469      P=0.500N     P=0.309      P=0.753N    |P=0.598      P=0.495N     P=0.495N     P=0.747N     | 
|ORDER RESTRICTED   |     P=0.276      (e)          (e)          (e)         |P=0.383N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 55      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  42/50 (84%)  45/50 (90%)  41/50 (82%) |47/49 (96%)  45/50 (90%)  40/50 (80%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |     45/48.70     42/47.82     45/49.59     41/47.15    |47/48.77     45/49.03     40/49.34     45/49.48     | 
|POLY-3 PERCENT (g) |     92.4%        87.8%        90.7%        87.0%       |96.4%        91.8%        81.1%        91.0%        | 
|TERMINAL (d)       |     22/22 (100%) 25/27 (93%)  29/31 (94%)  2/2 (100%)  |32/32 (100%) 36/38 (95%)  30/37 (81%)  33/34 (97%)  | 
|FIRST INCIDENCE    |     425          344          486          487         |358          613          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.123N     P=0.054N     P<0.001 **  |P=0.325N     P=0.059N     P=0.020N*    P=0.264N     | 
|POLY 3             |     P=0.273N     P=0.323N     P=0.528N     P=0.266N    |P=0.191N     P=0.285N     P=0.015N*    P=0.236N     | 
|POLY 1.5           |     P=0.238N     P=0.304N     P=0.577N     P=0.227N    |P=0.197N     P=0.255N     P=0.015N*    P=0.230N     | 
|POLY 6             |     P=0.354N     P=0.342N     P=0.439N     P=0.365N    |P=0.187N     P=0.336N     P=0.015N*    P=0.247N     | 
|LOGISTIC REGRESSION|     P=0.256N     P=0.300N     P=0.623N     P=0.204N    |P=0.202N     P=0.160N     P=0.018N*    P=0.225N     | 
|COCH-ARM / FISHERS |     P=0.211N     P=0.277N     P=0.630N     P=0.194N    |P=0.208N     P=0.226N     P=0.015N*    P=0.226N     | 
|ORDER RESTRICTED   |     P=0.269N     (e)          (e)          (e)         |P=0.051N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    9/50 (18%)   4/50 (8%)   |0/49 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/42.09      2/41.62      9/44.96      4/33.63     |0/44.06      1/47.49      1/47.33      2/46.80      | 
|POLY-3 PERCENT (g) |     14.3%        4.8%         20.0%        11.9%       |0.0%         2.1%         2.1%         4.3%         | 
|TERMINAL (d)       |     5/22 (23%)   1/27 (4%)    7/31 (23%)   0/2 (0%)    |0/32 (0%)    1/38 (3%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     725          715          543          488         |---          729 (T)      701          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.038 *    P=0.083N     P=0.536      P=0.092     |P=0.157      P=0.534      P=0.515      P=0.259      | 
|POLY 3             |     P=0.421      P=0.135N     P=0.335      P=0.516N    |P=0.164      P=0.515      P=0.514      P=0.251      | 
|POLY 1.5           |     P=0.513      P=0.136N     P=0.312      P=0.442N    |P=0.162      P=0.511      P=0.511      P=0.248      | 
|POLY 6             |     P=0.286      P=0.127N     P=0.373      P=0.623     |P=0.164      P=0.518      P=0.517      P=0.252      | 
|LOGISTIC REGRESSION|     P=0.386      P=0.091N     P=0.369      P=0.595N    |P=0.110      P=0.534      P=0.501      P=0.106      | 
|COCH-ARM / FISHERS |     P=0.516N     P=0.134N     P=0.288      P=0.370N    |P=0.155      P=0.505      P=0.505      P=0.253      | 
|ORDER RESTRICTED   |     P=0.305      (e)          (e)          (e)         |P=0.130      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 56      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    7/50 (14%)   1/50 (2%)   |1/49 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.76      3/41.56      7/44.30      1/32.09     |1/44.06      1/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.3%         7.2%         15.8%        3.1%        |2.3%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    3/27 (11%)   7/31 (23%)   0/2 (0%)    |1/32 (3%)    1/38 (3%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          729 (T)      729 (T)      708         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061      P=0.358      P=0.075      P=0.634     |P=0.228N     P=0.723N     P=0.471N     P=0.488N     | 
|POLY 3             |     P=0.317      P=0.294      P=0.033 *    P=0.693     |P=0.231N     P=0.744N     P=0.486N     P=0.492N     | 
|POLY 1.5           |     P=0.444      P=0.297      P=0.032 *    P=0.727     |P=0.232N     P=0.748N     P=0.489N     P=0.493N     | 
|POLY 6             |     P=0.155      P=0.297      P=0.037 *    P=0.629     |P=0.231N     P=0.741N     P=0.484N     P=0.494N     | 
|LOGISTIC REGRESSION|     P=0.282      P=0.308      P=0.036 *    P=0.678N    |P=0.228N     P=0.723N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.580      P=0.309      P=0.030 *    P=0.753N    |P=0.233N     P=0.747N     P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.157      (e)          (e)          (e)         |P=0.243N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.42      2/42.67      0/44.30      1/32.71     |0/44.06      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.7%         0.0%         3.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     632          344          ---          487         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.592N     P=0.486      P=0.505N     P=0.704     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.515N     P=0.502      P=0.491N     P=0.700     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.513N     P=0.500      P=0.495N     P=0.731     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.509N     P=0.508      P=0.484N     P=0.639     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.422N     P=0.628      P=0.521N     P=0.658N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.500N     P=0.753N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.443N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 57      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation Hemosiderin                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     39/50 (78%)  43/50 (86%)  44/50 (88%)  43/50 (86%) |48/49 (98%)  50/50 (100%) 49/50 (98%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     39/46.94     43/46.79     44/48.53     43/46.78    |48/48.98     50/50.00     49/49.90     49/50.00     | 
|POLY-3 PERCENT (g) |     83.1%        91.9%        90.7%        91.9%       |98.0%        100.0%       98.2%        98.0%        | 
|TERMINAL (d)       |     21/22 (96%)  27/27 (100%) 31/31 (100%) 2/2 (100%)  |32/32 (100%) 38/38 (100%) 37/37 (100%) 33/34 (97%)  | 
|FIRST INCIDENCE    |     506          373          486          488         |358          609          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.475N     P=0.198N     P<0.001 **  |P=0.526N     P=0.208N     P=0.218N     P=0.472N     | 
|POLY 3             |     P=0.133      P=0.137      P=0.193      P=0.133     |P=0.543N     P=0.504      P=0.751      P=0.762N     | 
|POLY 1.5           |     P=0.168      P=0.164      P=0.172      P=0.171     |P=0.543N     P=0.500      P=0.753      P=0.759      | 
|POLY 6             |     P=0.089      P=0.110      P=0.219      P=0.090     |P=0.542N     P=0.513      P=0.747      P=0.760N     | 
|LOGISTIC REGRESSION|     P=0.050      P=0.140      P=0.181      P=0.052     |P=0.543N     P=0.481      P=0.750      P=0.762N     | 
|COCH-ARM / FISHERS |     P=0.205      P=0.218      P=0.143      P=0.218     |P=0.543N     P=0.495      P=0.747      P=0.747      | 
|ORDER RESTRICTED   |     P=0.088      (e)          (e)          (e)         |P=0.527N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/49 (0%)    5/50 (10%)   0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.76      0/41.56      1/44.30      2/32.81     |0/44.06      5/48.19      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.3%         6.1%        |0.0%         10.4%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    2/38 (5%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          ---          729 (T)      507         |---          609          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.120      P=0.508N     P=0.725N     P=0.372     |P=0.201N     P=0.049 *    (e)          (e)          | 
|POLY 3             |     P=0.199      P=0.506N     P=0.753N     P=0.409     |P=0.171N     P=0.039 *    (e)          (e)          | 
|POLY 1.5           |     P=0.221      P=0.505N     P=0.757N     P=0.453     |P=0.176N     P=0.037 *    (e)          (e)          | 
|POLY 6             |     P=0.181      P=0.504N     P=0.745N     P=0.338     |P=0.169N     P=0.041 *    (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.334      P=0.363N     P=0.735      P=0.674     |P=0.207N     P=0.025 *    (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.247      P=0.500N     P=0.753N     P=0.500     |P=0.195N     P=0.030 *    (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.151      (e)          (e)          (e)         |P=0.081N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 58      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   4/49 (8%)    10/49 (20%)  17/50 (34%) |2/50 (4%)    2/50 (4%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     7/43.39      4/41.59      10/44.53     17/38.13    |2/44.94      2/47.91      2/47.42      4/46.24      | 
|POLY-3 PERCENT (g) |     16.1%        9.6%         22.5%        44.6%       |4.5%         4.2%         4.2%         8.7%         | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    6/31 (19%)   0/2 (0%)    |0/32 (0%)    1/38 (3%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     582          698          494          487         |430          609          679          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.222N     P=0.494      P<0.001 **  |P=0.223      P=0.656N     P=0.660N     P=0.346      | 
|POLY 3             |     P<0.001 **   P=0.284N     P=0.315      P=0.003 **  |P=0.225      P=0.671N     P=0.674N     P=0.350      | 
|POLY 1.5           |     P<0.001 **   P=0.282N     P=0.300      P=0.007 **  |P=0.226      P=0.678N     P=0.680N     P=0.348      | 
|POLY 6             |     P<0.001 **   P=0.281N     P=0.341      P<0.001 **  |P=0.223      P=0.665N     P=0.670N     P=0.350      | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.275N     P=0.279      P=0.031 *   |P=0.167      P=0.533      P=0.586      P=0.272      | 
|COCH-ARM / FISHERS |     P=0.002 **   P=0.274N     P=0.282      P=0.017 *   |P=0.221      P=0.691N     P=0.691N     P=0.339      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.287      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   6/49 (12%)   8/49 (16%)   12/50 (24%) |4/50 (8%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     8/43.57      6/42.59      8/43.86      12/35.75    |4/45.54      2/47.91      2/47.53      3/46.13      | 
|POLY-3 PERCENT (g) |     18.4%        14.1%        18.2%        33.6%       |8.8%         4.2%         4.2%         6.5%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    4/31 (13%)   0/2 (0%)    |0/32 (0%)    1/38 (3%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     582          610          669          537         |430          609          644          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.361N     P=0.415N     P=0.002 **  |P=0.479N     P=0.300N     P=0.307N     P=0.494N     | 
|POLY 3             |     P=0.051      P=0.403N     P=0.603N     P=0.095     |P=0.483N     P=0.314N     P=0.318N     P=0.493N     | 
|POLY 1.5           |     P=0.076      P=0.407N     P=0.603      P=0.149     |P=0.480N     P=0.321N     P=0.323N     P=0.492N     | 
|POLY 6             |     P=0.029 *    P=0.389N     P=0.584N     P=0.040 *   |P=0.487N     P=0.310N     P=0.315N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.093      P=0.399N     P=0.606N     P=0.171     |P=0.577      P=0.543N     P=0.507N     P=0.602N     | 
|COCH-ARM / FISHERS |     P=0.116      P=0.403N     P=0.590      P=0.227     |P=0.479N     P=0.339N     P=0.339N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.043 *    (e)          (e)          (e)         |P=0.352N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 59      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    1/49 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      1/41.71      1/43.40      3/32.76     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.3%         9.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          590          726          621         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.500      P=0.566      P=0.021 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.036 *    P=0.498      P=0.506      P=0.080     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.044 *    P=0.496      P=0.501      P=0.097     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.030 *    P=0.504      P=0.515      P=0.057     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.059      P=0.535      P=0.549      P=0.079     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.055      P=0.495      P=0.495      P=0.121     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.020 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/49 (2%)    8/49 (16%)   8/50 (16%)  |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/43.11      1/41.36      8/43.86      8/34.69     |0/44.12      1/47.91      1/47.41      2/45.97      | 
|POLY-3 PERCENT (g) |     9.3%         2.4%         18.2%        23.1%       |0.0%         2.1%         2.1%         4.4%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    4/31 (13%)   0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     582          698          669          529         |---          609          679          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.178N     P=0.319      P=0.014 *   |P=0.156      P=0.521      P=0.523      P=0.254      | 
|POLY 3             |     P=0.014 *    P=0.191N     P=0.183      P=0.086     |P=0.160      P=0.516      P=0.514      P=0.246      | 
|POLY 1.5           |     P=0.023 *    P=0.190N     P=0.176      P=0.125     |P=0.159      P=0.511      P=0.510      P=0.244      | 
|POLY 6             |     P=0.007 **   P=0.189N     P=0.199      P=0.043 *   |P=0.159      P=0.521      P=0.518      P=0.246      | 
|LOGISTIC REGRESSION|     P=0.030 *    P=0.181N     P=0.176      P=0.217     |P=0.128      P=0.385      P=0.478      P=0.240      | 
|COCH-ARM / FISHERS |     P=0.041 *    P=0.187N     P=0.168      P=0.178     |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.018 *    (e)          (e)          (e)         |P=0.126      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 60      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/49 (6%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/43.49      2/42.19      3/43.62      3/33.08     |0/44.12      1/47.91      1/47.53      1/45.76      | 
|POLY-3 PERCENT (g) |     11.5%        4.7%         6.9%         9.1%        |0.0%         2.1%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     549          610          691          569         |---          609          644          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.452      P=0.222N     P=0.268N     P=0.530     |P=0.392      P=0.521      P=0.527      P=0.512      | 
|POLY 3             |     P=0.455N     P=0.228N     P=0.354N     P=0.513N    |P=0.395      P=0.516      P=0.515      P=0.507      | 
|POLY 1.5           |     P=0.417N     P=0.226N     P=0.361N     P=0.436N    |P=0.394      P=0.511      P=0.510      P=0.506      | 
|POLY 6             |     P=0.498N     P=0.225N     P=0.340N     P=0.641N    |P=0.392      P=0.521      P=0.518      P=0.506      | 
|LOGISTIC REGRESSION|     P=0.315N     P=0.192N     P=0.389N     P=0.271N    |P=0.331      P=0.385      P=0.438      P=0.512      | 
|COCH-ARM / FISHERS |     P=0.369N     P=0.218N     P=0.369N     P=0.357N    |P=0.384      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.372N     (e)          (e)          (e)         |P=0.335      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   4/49 (8%)    7/50 (14%)  |0/50 (0%)    0/50 (0%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     5/43.17      5/42.18      4/43.53      7/33.63     |0/44.12      0/47.49      2/47.88      3/45.97      | 
|POLY-3 PERCENT (g) |     11.6%        11.9%        9.2%         20.8%       |0.0%         0.0%         4.2%         6.5%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    3/31 (10%)   1/2 (50%)   |0/32 (0%)    0/38 (0%)    0/37 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     495          673          691          549         |---          ---          633          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.009 **   P=0.565N     P=0.358N     P=0.010 *   |P=0.029 *    (e)          P=0.267      P=0.136      | 
|POLY 3             |     P=0.194      P=0.616      P=0.495N     P=0.216     |P=0.028 *    (e)          P=0.256      P=0.126      | 
|POLY 1.5           |     P=0.241      P=0.618      P=0.504N     P=0.290     |P=0.028 *    (e)          P=0.250      P=0.125      | 
|POLY 6             |     P=0.147      P=0.626      P=0.476N     P=0.120     |P=0.027 *    (e)          P=0.261      P=0.126      | 
|LOGISTIC REGRESSION|     P=0.207      P=0.630      P=0.514N     P=0.277     |P=0.023 *    (e)          P=0.152      P=0.126      | 
|COCH-ARM / FISHERS |     P=0.305      P=0.630N     P=0.513N     P=0.380     |P=0.028 *    (e)          P=0.247      P=0.121      | 
|ORDER RESTRICTED   |     P=0.166      (e)          (e)          (e)         |P=0.041 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 61      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    5/49 (10%)   15/50 (30%) |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      5/44.20      15/37.26    |0/44.12      2/47.90      2/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         11.3%        40.3%       |0.0%         4.2%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    1/38 (3%)    2/37 (5%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          486          488         |---          613          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.066      P<0.001 **  |P=0.494N     P=0.268      P=0.271      (e)          | 
|POLY 3             |     P<0.001 **   (e)          P=0.034 *    P<0.001 **  |P=0.482N     P=0.256      P=0.253      (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.032 *    P<0.001 **  |P=0.486N     P=0.250      P=0.248      (e)          | 
|POLY 6             |     P<0.001 **   (e)          P=0.039 *    P<0.001 **  |P=0.484N     P=0.261      P=0.256      (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.029 *    P<0.001 **  |P=0.505N     P=0.190      P=0.271      (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.027 *    P<0.001 **  |P=0.500N     P=0.247      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.282N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    4/50 (8%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.28      0/41.56      1/43.38      4/33.09     |1/44.49      0/47.49      0/47.22      1/45.95      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.3%         12.1%       |2.3%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     676          ---          729 (T)      529         |624          ---          ---          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.511N     P=0.711N     P=0.021 *   |P=0.605      P=0.487N     P=0.483N     P=0.745N     | 
|POLY 3             |     P=0.025 *    P=0.503N     P=0.755N     P=0.113     |P=0.591      P=0.487N     P=0.488N     P=0.753N     | 
|POLY 1.5           |     P=0.028 *    P=0.503N     P=0.760N     P=0.143     |P=0.592      P=0.491N     P=0.491N     P=0.754N     | 
|POLY 6             |     P=0.023 *    P=0.501N     P=0.747N     P=0.074     |P=0.589      P=0.485N     P=0.487N     P=0.755N     | 
|LOGISTIC REGRESSION|     P=0.030 *    P=0.500N     P=0.758N     P=0.146     |P=0.539      P=0.594N     P=0.586N     P=0.734      | 
|COCH-ARM / FISHERS |     P=0.034 *    P=0.500N     P=0.747      P=0.181     |P=0.595      P=0.500N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.011 *    (e)          (e)          (e)         |P=0.387N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 62      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/42.08      2/43.03      0/44.30      0/32.01     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          373          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.409N     P=0.233      (e)          (e)         |                                                    | 
|POLY 3             |     P=0.427N     P=0.242      (e)          (e)         |                                                    | 
|POLY 1.5           |     P=0.419N     P=0.239      (e)          (e)         |                                                    | 
|POLY 6             |     P=0.452N     P=0.248      (e)          (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.469N     P=0.420      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |                                                    | 
|ORDER RESTRICTED   |     P=0.310N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   6/50 (12%)   7/50 (14%)  |                                                    | 
|POLY-3 RATE (b)    |     6/43.97      5/42.89      6/45.54      7/33.81     |                                                    | 
|POLY-3 PERCENT (g) |     13.6%        11.7%        13.2%        20.7%       |                                                    | 
|TERMINAL (d)       |     0/22 (0%)    3/27 (11%)   2/31 (7%)    1/2 (50%)   |                                                    | 
|FIRST INCIDENCE    |     495          484          494          555         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    P=0.446N     P=0.495N     P=0.049 *   |                                                    | 
|POLY 3             |     P=0.233      P=0.518N     P=0.596N     P=0.303     |                                                    | 
|POLY 1.5           |     P=0.297      P=0.514N     P=0.608N     P=0.395     |                                                    | 
|POLY 6             |     P=0.168      P=0.516N     P=0.574N     P=0.176     |                                                    | 
|LOGISTIC REGRESSION|     P=0.504      P=0.447N     P=0.564      P=0.575     |                                                    | 
|COCH-ARM / FISHERS |     P=0.384      P=0.500N     P=0.620N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.271      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 63      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  12/50 (24%)  14/50 (28%)  22/50 (44%) |                                                    | 
|POLY-3 RATE (b)    |     15/46.34     12/45.11     14/48.12     22/41.48    |                                                    | 
|POLY-3 PERCENT (g) |     32.4%        26.6%        29.1%        53.0%       |                                                    | 
|TERMINAL (d)       |     2/22 (9%)    5/27 (19%)   4/31 (13%)   1/2 (50%)   |                                                    | 
|FIRST INCIDENCE    |     425          344          486          487         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.277N     P=0.328N     P<0.001 **  |                                                    | 
|POLY 3             |     P=0.017 *    P=0.353N     P=0.451N     P=0.035 *   |                                                    | 
|POLY 1.5           |     P=0.026 *    P=0.345N     P=0.474N     P=0.061     |                                                    | 
|POLY 6             |     P=0.009 **   P=0.358N     P=0.414N     P=0.012 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.373      P=0.257N     P=0.543      P=0.567N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.042 *    P=0.326N     P=0.500N     P=0.107     |                                                    | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     44/48 (92%)  42/48 (88%)  47/48 (98%)  46/48 (96%) |49/50 (98%)  48/49 (98%)  44/46 (96%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     44/46.94     42/45.61     47/47.53     46/47.71    |49/49.98     48/49.00     44/45.30     49/50.00     | 
|POLY-3 PERCENT (g) |     93.7%        92.1%        98.9%        96.4%       |98.0%        98.0%        97.1%        98.0%        | 
|TERMINAL (d)       |     22/22 (100%) 25/26 (96%)  31/31 (100%) 1/1 (100%)  |32/32 (100%) 36/37 (97%)  33/33 (100%) 33/34 (97%)  | 
|FIRST INCIDENCE    |     425          373          486          487         |288          609          609          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.193N     P=0.108N     P<0.001 **  |P=0.483N     P=0.128N     P=0.126N     P=0.405N     | 
|POLY 3             |     P=0.220      P=0.542N     P=0.182      P=0.445     |P=0.617N     P=0.754N     P=0.658N     P=0.758N     | 
|POLY 1.5           |     P=0.176      P=0.488N     P=0.177      P=0.392     |P=0.606N     P=0.755N     P=0.578N     P=0.759N     | 
|POLY 6             |     P=0.286      P=0.553N     P=0.209      P=0.539     |P=0.627N     P=0.751N     P=0.749N     P=0.756N     | 
|LOGISTIC REGRESSION|     P=0.062      P=0.470N     P=0.193      P=0.424     |P=0.562N     P=0.747      P=0.390N     P=0.762N     | 
|COCH-ARM / FISHERS |     P=0.132      P=0.370N     P=0.181      P=0.339     |P=0.589N     P=0.747N     P=0.468N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.172      (e)          (e)          (e)         |P=0.669N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 64      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Ectopic Parathyroid Gland                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    1/48 (2%)    0/48 (0%)    4/48 (8%)   |0/50 (0%)    0/49 (0%)    0/46 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/40.99      1/39.93      0/42.48      4/30.98     |0/44.12      0/46.49      0/43.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         2.5%         0.0%         12.9%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    1/26 (4%)    0/31 (0%)    0/1 (0%)    |0/32 (0%)    0/37 (0%)    0/33 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          624         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.533      (e)          P=0.004 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.009 **   P=0.495      (e)          P=0.032 *   |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.010 *    P=0.496      (e)          P=0.043 *   |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.011 *    P=0.496      (e)          P=0.018 *   |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.005 **   P=0.533      (e)          P=0.020 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.500      (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      2/44.89      1/32.35     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         3.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          543          634         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113      (e)          P=0.277      P=0.388     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.152      (e)          P=0.252      P=0.448     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.195      (e)          P=0.245      P=0.473     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.101      (e)          P=0.263      P=0.406     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.296      (e)          P=0.214      P=0.536     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.191      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 65      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  8/50 (16%)   8/50 (16%)   5/50 (10%)  |34/50 (68%)  11/50 (22%)  13/50 (26%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     17/45.18     8/41.93      8/44.90      5/33.78     |34/47.78     11/47.99     13/47.64     8/46.28      | 
|POLY-3 PERCENT (g) |     37.6%        19.1%        17.8%        14.8%       |71.2%        22.9%        27.3%        17.3%        | 
|TERMINAL (d)       |     6/22 (27%)   7/27 (26%)   6/31 (19%)   0/2 (0%)    |23/32 (72%)  8/38 (21%)   11/37 (30%)  6/34 (18%)   | 
|FIRST INCIDENCE    |     495          624          543          487         |430          613          633          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.217N     P=0.021N*    P=0.010N*    P=0.516N    |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|POLY 3             |     P=0.012N*    P=0.043N*    P=0.028N*    P=0.021N*   |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|POLY 1.5           |     P=0.007N**   P=0.039N*    P=0.029N*    P=0.008N**  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|POLY 6             |     P=0.024N*    P=0.047N*    P=0.025N*    P=0.080N    |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.008N**   P=0.034N*    P=0.034N*    P=0.004N**  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.004N**   P=0.032N*    P=0.032N*    P=0.004N**  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.012N*    (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.08      2/41.56      0/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.362N     P=0.572      P=0.432N     P=0.934N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.202N     P=0.496      P=0.490N     P=0.554N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.198N     P=0.495      P=0.495N     P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.210N     P=0.501      P=0.481N     P=0.598N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.362N     P=0.572      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.226N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 66      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |0/44.12      2/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    2/38 (5%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.399N     P=0.277      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.384N     P=0.254      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.389N     P=0.249      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.382N     P=0.258      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.277      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.255N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/3 (33%)    0/5 (0%)     1/2 (50%)    1/3 (33%)   |0/0 (0%)     0/0 (0%)     3/3 (100%)   2/3 (67%)    | 
|POLY-3 RATE (b)    |     1/2.67       0/2.63       1/1.53       1/2.60      |0/0.00       0/0.00       3/3.00       2/2.84       | 
|POLY-3 PERCENT (g) |     37.5%        0.0%         65.4%        38.5%       |0.0%         0.0%         100.0%       70.5%        | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |0/0 (0%)     0/0 (0%)     3/3 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     676          ---          691          691         |---          ---          729 (T)      624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.482N     P=0.696N     P=0.396     |P=0.190      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.574      P=0.504N     P=0.650      P=0.768     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.536      P=0.455N     P=0.659      P=0.764     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.621      P=0.575N     P=0.636      P=0.774     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.565      P=0.585N     P=0.625      P=0.806     |P=0.660N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.472      P=0.375N     P=0.700      P=0.800N    |P=0.500N     (e)          (e)          P=1.000      | 
|ORDER RESTRICTED   |     P=0.355      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 67      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Trachea                                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    8/50 (16%)   3/50 (6%)   |0/50 (0%)    4/50 (8%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.40      1/42.18      8/45.58      3/33.29     |0/44.12      4/48.04      2/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         2.4%         17.6%        9.0%        |0.0%         8.3%         4.2%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    4/31 (13%)   0/2 (0%)    |0/32 (0%)    2/38 (5%)    2/37 (5%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     681          526          486          487         |---          609          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.031 *    P=0.482N     P=0.110      P=0.195     |P=0.576N     P=0.084      P=0.271      P=0.512      | 
|POLY 3             |     P=0.112      P=0.502N     P=0.057      P=0.391     |P=0.552N     P=0.072      P=0.253      P=0.507      | 
|POLY 1.5           |     P=0.172      P=0.503N     P=0.052      P=0.444     |P=0.558N     P=0.068      P=0.248      P=0.506      | 
|POLY 6             |     P=0.050      P=0.496N     P=0.067      P=0.304     |P=0.553N     P=0.075      P=0.256      P=0.506      | 
|LOGISTIC REGRESSION|     P=0.318      P=0.470N     P=0.044 *    P=0.589     |P=0.575N     P=0.051      P=0.271      P=0.512      | 
|COCH-ARM / FISHERS |     P=0.256      P=0.500N     P=0.046 *    P=0.500     |P=0.577N     P=0.059      P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.092      (e)          (e)          (e)         |P=0.172      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.42      0/41.56      2/44.45      2/32.47     |1/44.12      1/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     6.9%         0.0%         4.5%         6.2%        |2.3%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     495          ---          691          639         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.358      P=0.123N     P=0.437N     P=0.546     |P=0.228N     P=0.723N     P=0.471N     P=0.488N     | 
|POLY 3             |     P=0.543      P=0.126N     P=0.489N     P=0.629N    |P=0.233N     P=0.744N     P=0.486N     P=0.493N     | 
|POLY 1.5           |     P=0.582      P=0.124N     P=0.495N     P=0.568N    |P=0.234N     P=0.749N     P=0.490N     P=0.494N     | 
|POLY 6             |     P=0.502      P=0.126N     P=0.476N     P=0.623     |P=0.232N     P=0.740N     P=0.484N     P=0.494N     | 
|LOGISTIC REGRESSION|     P=0.508N     P=0.075N     P=0.547N     P=0.358N    |P=0.228N     P=0.723N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.578N     P=0.121N     P=0.500N     P=0.500N    |P=0.235N     P=0.753N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.379N     (e)          (e)          (e)         |P=0.244N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/21/03                           EXPERIMENT: 88138 TEST: 03                                            Page 68      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/50 (24%)  20/50 (40%)  20/50 (40%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |                                                        |12/44.72     20/48.06     20/47.84     20/46.41     | 
|POLY-3 PERCENT (g) |                                                        |26.8%        41.6%        41.8%        43.1%        | 
|TERMINAL (d)       |                                                        |8/32 (25%)   16/38 (42%)  16/37 (43%)  17/34 (50%)  | 
|FIRST INCIDENCE    |                                                        |634          633          644          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.108      P=0.175      P=0.158      P=0.095      | 
|POLY 3             |                                                        |P=0.110      P=0.099      P=0.096      P=0.077      | 
|POLY 1.5           |                                                        |P=0.110      P=0.088      P=0.086      P=0.076      | 
|POLY 6             |                                                        |P=0.101      P=0.105      P=0.101      P=0.072      | 
|LOGISTIC REGRESSION|                                                        |P=0.100      P=0.108      P=0.104      P=0.078      | 
|COCH-ARM / FISHERS |                                                        |P=0.098      P=0.066      P=0.066      P=0.066      | 
|ORDER RESTRICTED   |                                                        |P=0.084      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Serosa                                                                                                                   | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.12      2/47.63      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.2%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/32 (0%)    1/38 (3%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          693          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.409N     P=0.270      (e)          (e)          | 
|POLY 3             |                                                        |P=0.384N     P=0.255      (e)          (e)          | 
|POLY 1.5           |                                                        |P=0.389N     P=0.249      (e)          (e)          | 
|POLY 6             |                                                        |P=0.381N     P=0.259      (e)          (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.402N     P=0.246      (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.255N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.