National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7493

TDMS Study 88138-04 Pathology Tables

NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04
Route: DOSED FEED                                                                                                 Time: 13:24:25

                                                          FINAL#2 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  04/26/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            2            5            6                                     
    Natural Death                                      6            6            4           12                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           42           41           31                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (49)         (50)         (50)         (50)                                   
      Cyst                                                          1 (2%)       1 (2%)                                             
      Infiltration Cellular, Lymphoid                                            1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
      Mineralization                                                             1 (2%)                                             
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          3 (6%)                    1 (2%)                                
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)                    1 (2%)       4 (8%)                                
      Basophilic Focus                                 3 (6%)                    1 (2%)       2 (4%)                                
      Clear Cell Focus                                 3 (6%)       2 (4%)       4 (8%)       4 (8%)                                
      Eosinophilic Focus                               2 (4%)       2 (4%)       7 (14%)      7 (14%)                               
      Hematopoietic Cell Proliferation                18 (36%)     11 (22%)     20 (40%)     19 (38%)                               
      Infarct                                                                                 1 (2%)                                
      Infiltration Cellular, Lymphoid                 36 (72%)     38 (76%)     35 (70%)     35 (70%)                               
      Inflammation, Chronic Active                    44 (88%)     40 (80%)     41 (82%)     36 (72%)                               
      Mineralization                                                             1 (2%)                                             
      Mixed Cell Focus                                 2 (4%)       5 (10%)      3 (6%)       2 (4%)                                
      Tension Lipidosis                                4 (8%)       8 (16%)      3 (6%)       7 (14%)                               
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Hepatocyte, Autolysis                                                                   1 (2%)                                
      Hepatocyte, Mitotic Alteration                                             1 (2%)                                             
      Hepatocyte, Multinucleated                                                              2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Necrosis                             3 (6%)       5 (10%)      4 (8%)                                             
      Hepatocyte, Vacuolization Cytoplasmic           41 (82%)     43 (86%)     39 (78%)     34 (68%)                               
      Hepatocyte, Centrilobular, Degeneration                                                 1 (2%)                                
      Hepatocyte, Centrilobular, Hypertrophy                       29 (58%)     44 (88%)     37 (74%)                               
   Mesentery                                          (6)          (9)          (11)         (9)                                    
      Fat, Fibrosis                                    1 (17%)      2 (22%)      8 (73%)      4 (44%)                               
      Fat, Hemorrhage                                                                         1 (11%)                               
      Fat, Infiltration Cellular, Lymphoid                                       4 (36%)                                            
      Fat, Inflammation, Chronic Active                1 (17%)      3 (33%)      7 (64%)      3 (33%)                               
      Fat, Mineralization                                           1 (11%)      2 (18%)      1 (11%)                               
      Fat, Necrosis                                    1 (17%)      4 (44%)      9 (82%)      4 (44%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)       2 (4%)                                                          
      Infiltration Cellular, Lymphoid                 20 (40%)     24 (48%)     33 (66%)     18 (36%)                               
      Acinus, Atrophy                                  1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Acinus, Cytoplasmic Alteration                                1 (2%)                                                          
      Duct, Inflammation, Chronic Active                                         1 (2%)                                             
      Duct, Pigmentation                                                         1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 27 (54%)     34 (68%)     30 (60%)     28 (56%)                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Epithelium, Hyperkeratosis                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Epithelium, Hyperplasia, Squamous                1 (2%)       1 (2%)                    1 (2%)                                
      Epithelium, Ulcer                                1 (2%)                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Epithelium, Glands, Hyperplasia                  1 (2%)                                                                       
      Glands, Ectasia                                 18 (36%)     16 (32%)     22 (44%)     10 (20%)                               
      Glands, Mineralization                                        3 (6%)                    2 (4%)                                
   Tooth                                              (21)         (29)         (24)         (20)                                   
      Malformation                                                               1 (4%)                                             
      Gingiva, Inflammation, Chronic Active           21 (100%)    29 (100%)    24 (100%)    20 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Mineralization                                                                   1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                             1 (2%)                                             
      Hyperplasia, Atypical                                                      1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Necrosis                                         1 (2%)                                                                       
      Valve, Inflammation, Chronic Active              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      2 (4%)                                                                       
      Hypertrophy                                      1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                      1 (2%)                    1 (2%)                                
      Subcapsular, Hyperplasia                        49 (98%)     49 (98%)     49 (98%)     49 (100%)                              
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                                2 (4%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      3 (6%)       1 (2%)                                                          
   Parathyroid Gland                                  (42)         (41)         (40)         (40)                                   
      Cyst                                                                       3 (8%)       1 (3%)                                
   Pituitary Gland                                    (50)         (50)         (49)         (47)                                   
      Pars Distalis, Angiectasis                       2 (4%)       4 (8%)       5 (10%)      3 (6%)                                
      Pars Distalis, Cyst                              5 (10%)      3 (6%)       2 (4%)                                             
      Pars Distalis, Hyperplasia                      14 (28%)     14 (28%)     13 (27%)      3 (6%)                                
      Pars Distalis, Hypertrophy                                                 1 (2%)                                             
      Pars Distalis, Pigmentation                                                1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                               1 (2%)       2 (4%)       2 (4%)                                
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)                                             
      C-Cell, Hyperplasia                                                                     1 (2%)                                
      Follicle, Cyst                                                1 (2%)                                                          
      Follicle, Degeneration                          17 (34%)     19 (38%)     12 (24%)      9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Clitoral Gland                                     (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                     8 (16%)      1 (2%)                    2 (4%)                                
      Duct, Cyst                                       1 (2%)                                                                       
   Ovary                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Atrophy                                         48 (98%)     48 (96%)     46 (92%)     45 (90%)                               
      Cyst                                            22 (45%)     17 (34%)     17 (34%)     14 (28%)                               
      Hemorrhage                                       2 (4%)       5 (10%)      3 (6%)       4 (8%)                                
      Infiltration Cellular, Lymphoid                                                         1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       1 (2%)                                             
      Mineralization                                                4 (8%)       2 (4%)                                             
      Pigmentation                                     6 (12%)      2 (4%)       3 (6%)       1 (2%)                                
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     5 (10%)      4 (8%)       2 (4%)       2 (4%)                                
      Endometrium, Hyperplasia, Cystic                47 (96%)     45 (90%)     44 (88%)     43 (86%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Myelofibrosis                                   18 (36%)     30 (60%)     20 (40%)     26 (52%)                               
      Myeloid Cell, Hyperplasia                        1 (2%)                                                                       
   Lymph Node                                         (8)          (12)         (11)         (15)                                   
      Lumbar, Hyperplasia, Lymphoid                    1 (13%)      1 (8%)                    2 (13%)                               
      Mediastinal, Atrophy                             1 (13%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               2 (25%)      5 (42%)      4 (36%)      4 (27%)                               
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                     1 (13%)                                                                      
      Mediastinal, Inflammation, Chronic Active        1 (13%)                                                                      
      Pancreatic, Hyperplasia, Lymphoid                                          2 (18%)      1 (7%)                                
      Pancreatic, Pigmentation                                                   1 (9%)                                             
      Renal, Hemorrhage                                             1 (8%)                    1 (7%)                                
      Renal, Hyperplasia, Lymphoid                                  3 (25%)                   1 (7%)                                
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
      Hyperplasia, Lymphoid                            4 (8%)      20 (40%)     12 (24%)      9 (18%)                               
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)                                   
      Hyperplasia, Lymphoid                            6 (12%)     12 (24%)      6 (12%)      4 (8%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                16 (32%)     35 (70%)     32 (64%)     27 (54%)                               
      Hemorrhage                                                                              2 (4%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Necrosis                                                                                1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Lymphoid Follicle, Hyperplasia, Lymphoid        24 (48%)     36 (72%)     37 (74%)     22 (44%)                               
   Thymus                                             (46)         (50)         (50)         (50)                                   
      Atrophy                                          8 (17%)      7 (14%)      3 (6%)      13 (26%)                               
      Cyst                                            23 (50%)     35 (70%)     31 (62%)     24 (48%)                               
      Ectopic Parathyroid Gland                        1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         8 (16%)      5 (10%)      2 (4%)                                
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Thymocyte, Necrosis                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosis                                 1 (2%)                                                          
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
         Lymphoid                                                   4 (8%)       1 (2%)                                             
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
         Polymorphonuclear                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Maxilla, Fracture                                                                       1 (2%)                                
   Skeletal Muscle                                    (2)          (4)          (2)          (4)                                    
      Infiltration Cellular, Lymphoid                               3 (75%)      2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              2 (4%)                                
      Infiltration Cellular, Lymphoid                               1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Infiltration Cellular, Lymphoid                 33 (66%)     44 (88%)     44 (88%)     35 (70%)                               
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Metaplasia, Osseous                                                                     1 (2%)                                
      Pigmentation                                                                            2 (4%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Alveolus, Hemorrhage                             2 (4%)                                 3 (6%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                                 2 (4%)                                
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
        Active                                         1 (2%)                                                                       
      Olfactory Epithelium, Metaplasia                                                       39 (78%)                               
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Glands, Cyst                                                  1 (2%)                                                          
      Glands, Inflammation, Chronic Active                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)                                                                       
      Lens, Cataract                                                             1 (2%)                                             
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                   3 (6%)       3 (6%)       1 (2%)                                
      Infiltration Cellular, Lymphoid                 29 (58%)     27 (54%)     27 (54%)     23 (47%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                              1 (2%)       1 (2%)                                
      Atrophy                                          1 (2%)                                                                       
      Glomerulosclerosis                                                                      1 (2%)                                
      Hydronephrosis                                   2 (4%)                                 1 (2%)                                
      Infarct                                          4 (8%)       1 (2%)       3 (6%)       3 (6%)                                
      Infiltration Cellular, Lymphoid                 41 (82%)     45 (90%)     43 (86%)     39 (78%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)       2 (4%)       4 (8%)       2 (4%)                                
      Mineralization                                  15 (30%)     31 (62%)     36 (72%)     49 (98%)                               
      Nephropathy                                     21 (42%)     33 (66%)     31 (62%)     30 (60%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                                 1 (2%)                                
      Cortex, Cyst                                                  1 (2%)                                                          
      Renal Tubule, Pigmentation                       1 (2%)       1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Urinary Bladder                                    (50)         (49)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 37 (74%)     38 (78%)     40 (80%)     39 (78%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            3            5            2                                     
    Natural Death                                      1            3            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           44           44           45                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (49)         (49)         (49)                                   
      Cyst                                                                       1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 4 (8%)       2 (4%)       5 (10%)                                            
      Clear Cell Focus                                 2 (4%)       7 (14%)      7 (14%)     12 (24%)                               
      Eosinophilic Focus                               5 (10%)      8 (16%)     11 (22%)     10 (20%)                               
      Fatty Change                                                               1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)                                                          
      Infarct                                                       2 (4%)                    1 (2%)                                
      Infiltration Cellular, Lymphoid                  6 (12%)     10 (20%)                   4 (8%)                                
      Inflammation, Chronic Active                    33 (66%)     47 (94%)     44 (88%)     42 (84%)                               
      Mixed Cell Focus                                 8 (16%)      9 (18%)     15 (30%)     13 (26%)                               
      Tension Lipidosis                                1 (2%)       1 (2%)                    1 (2%)                                
      Bile Duct, Cyst                                               3 (6%)                    1 (2%)                                
      Hepatocyte, Degeneration, Cystic                                           5 (10%)     30 (60%)                               
      Hepatocyte, Multinucleated                                   41 (82%)     47 (94%)     48 (96%)                               
      Hepatocyte, Necrosis                             1 (2%)       6 (12%)      8 (16%)      8 (16%)                               
      Hepatocyte, Vacuolization Cytoplasmic           44 (88%)     45 (90%)     46 (92%)     44 (88%)                               
      Hepatocyte, Centrilobular, Hypertrophy                       44 (88%)     50 (100%)    48 (96%)                               
      Oval Cell, Hyperplasia                                                     1 (2%)                                             
   Mesentery                                                       (2)          (8)          (5)                                    
      Fat, Fibrosis                                                 1 (50%)      5 (63%)      1 (20%)                               
      Fat, Inflammation, Chronic Active                             1 (50%)      5 (63%)      2 (40%)                               
      Fat, Mineralization                                           1 (50%)      3 (38%)                                            
      Fat, Necrosis                                                 1 (50%)      5 (63%)                                            
      Fat, Pigmentation                                             1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst                                                                       1 (2%)       2 (4%)                                
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Infiltration Cellular, Lymphoid                 14 (28%)     11 (22%)      8 (16%)      8 (16%)                               
      Acinus, Atrophy                                               1 (2%)       1 (2%)       1 (2%)                                
      Acinus, Cytoplasmic Alteration                                             1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Infiltration Cellular, Lymphoid                 31 (62%)     40 (80%)     40 (80%)     28 (56%)                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       2 (4%)                                                          
      Epithelium, Cyst                                              1 (2%)                                                          
      Epithelium, Hyperkeratosis                       1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Epithelium, Hyperplasia, Squamous                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Epithelium, Ulcer                                1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Glands, Ectasia                                  7 (14%)     13 (26%)     18 (36%)      5 (10%)                               
      Glands, Mineralization                                                     1 (2%)       1 (2%)                                
   Tooth                                              (20)         (31)         (33)         (21)                                   
      Inflammation, Chronic Active                     1 (5%)                    3 (9%)                                             
      Malformation                                     3 (15%)      1 (3%)       3 (9%)                                             
      Gingiva, Inflammation, Chronic Active           18 (90%)     30 (97%)     32 (97%)     20 (95%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hyperplasia, Atypical                                                                   1 (2%)                                
      Inflammation, Chronic Active                     3 (6%)       5 (10%)      3 (6%)       3 (6%)                                
      Mineralization                                   1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Degeneration, Fatty                                                        2 (4%)                                             
      Hyperplasia                                      7 (14%)     10 (20%)      9 (18%)      6 (12%)                               
      Hypertrophy                                     26 (52%)     22 (44%)     24 (48%)     18 (36%)                               
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Subcapsular, Hyperplasia                        50 (100%)    46 (92%)     46 (92%)     47 (94%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (48)         (49)         (50)         (50)                                   
      Pars Distalis, Cyst                              7 (15%)      5 (10%)      5 (10%)      4 (8%)                                
      Pars Distalis, Hyperplasia                       1 (2%)       1 (2%)                                                          
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                                            1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Follicle, Cyst                                   2 (4%)                                 1 (2%)                                
      Follicle, Degeneration                          12 (24%)      9 (18%)      6 (12%)      6 (12%)                               
      Follicular Cell, Hyperplasia                                               1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Degeneration                                                  1 (2%)                                                          
      Granuloma Sperm                                  1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Infiltration Cellular, Lymphoid                 32 (64%)     27 (54%)     30 (60%)     31 (62%)                               
      Mineralization                                                             4 (8%)                                             
      Spermatocele                                                               1 (2%)                                             
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                    21 (42%)     23 (46%)     25 (50%)     32 (64%)                               
      Duct, Ectasia                                   20 (40%)     15 (30%)     15 (30%)     28 (56%)                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 32 (64%)     43 (86%)     46 (92%)     28 (56%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                          1 (2%)                    1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Mineralization                                                1 (2%)       4 (8%)      12 (24%)                               
      Germinal Epithelium, Degeneration                             3 (6%)       1 (2%)       2 (4%)                                
      Rete Testes, Cyst                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Myeloid Cell, Hyperplasia                                                  1 (2%)                                             
   Lymph Node                                         (1)          (1)          (3)          (5)                                    
      Deep Cervical, Hyperplasia, Lymphoid                                       1 (33%)                                            
      Mediastinal, Hyperplasia, Lymphoid                            1 (100%)     1 (33%)                                            
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                     1 (100%)                                                                     
      Mediastinal, Inflammation, Granulomatous                                                1 (20%)                               
   Lymph Node, Mandibular                             (48)         (50)         (49)         (47)                                   
      Hyperplasia, Lymphoid                            5 (10%)      1 (2%)       6 (12%)      5 (11%)                               
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (48)                                   
      Hyperplasia, Lymphoid                            2 (4%)       2 (4%)                    2 (4%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Hematopoietic Cell Proliferation                11 (22%)      7 (14%)      9 (18%)     14 (28%)                               
      Lymphoid Follicle, Hyperplasia, Lymphoid        17 (34%)     31 (62%)     34 (68%)     32 (64%)                               
   Thymus                                             (46)         (48)         (46)         (47)                                   
      Atrophy                                         12 (26%)      9 (19%)      6 (13%)      5 (11%)                               
      Cyst                                            16 (35%)     25 (52%)     20 (43%)     20 (43%)                               
      Ectopic Parathyroid Gland                        2 (4%)                                                                       
      Ectopic Thyroid                                                            1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Spinal Cord                                        (1)          (1)          (1)                                                 
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Degeneration                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 32 (64%)     38 (76%)     47 (94%)     36 (72%)                               
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Metaplasia, Osseous                                                        1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 6 (12%)      7 (14%)      8 (16%)      4 (8%)                                
      Alveolus, Infiltration Cellular, Histiocyte      7 (14%)      1 (2%)       1 (2%)       3 (6%)                                
      Mediastinum, Inflammation, Suppurative                                     1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)       2 (4%)                                
      Inflammation, Focal, Suppurative                                                        1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
        Active                                                                   2 (4%)       1 (2%)                                
      Olfactory Epithelium, Degeneration               1 (2%)                                                                       
      Olfactory Epithelium, Metaplasia                              2 (4%)       2 (4%)      24 (48%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Anterior Chamber, Iris, Inflammation,                                                                                         
        Suppurative                                                 1 (2%)                                                          
      Cornea, Inflammation, Chronic Active                          1 (2%)       2 (4%)       1 (2%)                                
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       3 (6%)       3 (6%)       2 (4%)                                
      Infiltration Cellular, Lymphoid                 37 (74%)     33 (66%)     24 (48%)     29 (58%)                               
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Infarct                                          1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Infiltration Cellular, Lymphoid                 44 (88%)     44 (88%)     45 (90%)     45 (90%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/01/04    
Route: DOSED FEED                                                                                                 Time: 13:24:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)                                             
      Metaplasia, Osseous                              4 (8%)       2 (4%)       1 (2%)       8 (16%)                               
      Mineralization                                  49 (98%)     50 (100%)    50 (100%)    50 (100%)                              
      Necrosis                                                                   1 (2%)                                             
      Nephropathy                                     49 (98%)     48 (96%)     50 (100%)    50 (100%)                              
      Artery, Inflammation, Chronic Active             1 (2%)       1 (2%)                                                          
      Cortex, Cyst                                     4 (8%)       8 (16%)     12 (24%)     22 (44%)                               
      Renal Tubule, Pigmentation                                                              1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 24 (48%)     24 (48%)     32 (64%)     23 (46%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.