National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7497

TDMS Study 88138-04 Pathology Tables

NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03
Route: DOSED FEED                                                                                                 Time: 08:31:29

                                                          FINAL#1/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  04/26/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            2            5            6                                     
    Natural Death                                      6            6            4           12                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           42           41           31                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
   Gallbladder                                        (49)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     2 (4%)                                
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma, Metastatic, Skeletal Muscle                                            1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Polyp Adenomatous                                1 (2%)                    3 (6%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma                                      1 (2%)                    1 (2%)                                
      Hepatocellular Adenoma                           4 (8%)       3 (6%)       7 (14%)      5 (10%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)       3 (6%)       3 (6%)                                
      Histiocytic Sarcoma                                                        5 (10%)      3 (6%)                                
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Mesentery                                          (6)          (9)          (11)         (9)                                    
      Fat, Fibrosarcoma, Metastatic, Skin                                                     1 (11%)                               
      Fat, Fibrous Histiocytoma, Metastatic, Skin                                             1 (11%)                               
      Fat, Hemangiosarcoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                              1 (11%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fat, Histiocytic Sarcoma                                                                2 (22%)                               
      Fat, Sarcoma Stromal, Metastatic, Uterus         1 (17%)                                                                      
   Oral Mucosa                                                     (2)                                                              
      Gingival, Mast Cell Tumor Malignant                           1 (50%)                                                         
      Pharyngeal, Squamous Cell Papilloma                           1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Histiocytic Sarcoma                                                                     2 (4%)                                
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                    2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Aorta, Fibrous Histiocytoma, Metastatic, Skin                                           1 (2%)                                
      Aorta, Histiocytic Sarcoma                                                              1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Histiocytic Sarcoma                                                                     3 (6%)                                
      Subcapsular, Adenoma                             1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Benign                          1 (2%)       1 (2%)                    2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Parathyroid Gland                                  (42)         (41)         (40)         (40)                                   
   Pituitary Gland                                    (50)         (50)         (49)         (47)                                   
      Pars Distalis, Adenoma                           2 (4%)                    2 (4%)       3 (6%)                                
      Pars Distalis, Histiocytic Sarcoma                                                      1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Ovary                                              (49)         (50)         (50)         (50)                                   
      Cystadenoma                                      1 (2%)       3 (6%)       3 (6%)       2 (4%)                                
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Histiocytic Sarcoma                                                        2 (4%)       3 (6%)                                
      Bilateral, Granulosa Cell Tumor Malignant                                  1 (2%)                                             
      Bilateral, Tubulostromal Adenoma                 1 (2%)                                                                       
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma, Metastatic, Skeletal Muscle                                            1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)       3 (6%)                                
      Leiomyoma                                                     1 (2%)                                                          
      Polyp Stromal                                    3 (6%)                                                                       
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                  1 (2%)                                                                       
      Bilateral, Polyp Stromal                                      1 (2%)                                                          
      Endometrium, Adenoma                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                    1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)       2 (4%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Lymph Node                                         (8)          (12)         (11)         (15)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (8%)                                                          
      Inguinal, Histiocytic Sarcoma                                                           1 (7%)                                
      Lumbar, Histiocytic Sarcoma                                                1 (9%)       2 (13%)                               
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                                               1 (7%)                                
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Skin                                                                    1 (7%)                                
      Mediastinal, Hemangiosarcoma, Metastatic,                                                                                     
           Skeletal Muscle                                                                    1 (7%)                                
      Mediastinal, Histiocytic Sarcoma                                                        3 (20%)                               
      Pancreatic, Fibrous Histiocytoma, Metastatic,                                                                                 
           Skin                                                                               1 (7%)                                
      Pancreatic, Histiocytic Sarcoma                                                         1 (7%)                                
      Renal, Fibrous Histiocytoma, Metastatic, Skin                                           1 (7%)                                
      Renal, Histiocytic Sarcoma                                                 1 (9%)       2 (13%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        3 (6%)       2 (4%)                                
      Mast Cell Tumor Malignant, Metastatic, Oral                                                                                   
          Mucosa                                                    1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Hemangiosarcoma, Metastatic, Skeletal Muscle                                            1 (2%)                                
      Histiocytic Sarcoma                                                        2 (4%)       3 (6%)                                
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Bone Marrow         1 (2%)                                                                       
      Histiocytic Sarcoma                                                        2 (4%)       3 (6%)                                
   Thymus                                             (46)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic, Oral                                                                                   
          Mucosa                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    4 (8%)       1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (2%)                                
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma                                                1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant,                                                                                    
           Multiple                                                 1 (2%)                                                          
      Subcutaneous Tissue, Trichoepithelioma                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Skeletal Muscle                                    (2)          (4)          (2)          (4)                                    
      Hemangiosarcoma                                                                         1 (25%)                               
      Histiocytic Sarcoma                                                                     1 (25%)                               
      Sarcoma Stromal, Metastatic, Uterus              1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  5 (10%)      2 (4%)       2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)       1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                                 1 (2%)       1 (2%)                                
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
      Hemangiosarcoma, Metastatic, Skeletal Muscle                                            1 (2%)                                
      Histiocytic Sarcoma                                                        5 (10%)      3 (6%)                                
      Osteosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Mediastinum, Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)       3 (6%)       2 (4%)       3 (6%)                                
      Carcinoma                                                                               1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin                                                  1 (2%)                                
      Histiocytic Sarcoma                                                        3 (6%)       3 (6%)                                
   Urinary Bladder                                    (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     3 (6%)                                
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        5 (10%)      3 (6%)                                
      Lymphoma Malignant                               8 (16%)      9 (18%)      5 (10%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            25          28          32          30                                       
     Total Primary Neoplasms                           34          39          49          45                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          17          19          19                                       
     Total Benign Neoplasms                            18          23          25          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          13          18          20                                       
     Total Malignant Neoplasms                         16          16          24          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           3           6                                       
     Total Metastatic Neoplasm                         10           7           3          31                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            3            5            2                                     
    Natural Death                                      1            3            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           44           44           45                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (49)         (49)         (49)                                   
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
      Hepatoblastoma                                                1 (2%)       1 (2%)       3 (6%)                                
      Hepatocellular Carcinoma                         6 (12%)      5 (10%)      4 (8%)       6 (12%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)                    2 (4%)                                             
      Hepatocellular Adenoma                           9 (18%)      7 (14%)     15 (30%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                 2 (4%)       8 (16%)      8 (16%)     12 (24%)                               
      Ito Cell Tumor Benign                                                      1 (2%)                                             
   Mesentery                                                       (2)          (8)          (5)                                    
      Fat, Hemangiosarcoma, Metastatic, Spleen                      1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       2 (4%)       3 (6%)                                             
      Squamous Cell Papilloma, Multiple                             1 (2%)                                                          
   Tongue                                                          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
   Tooth                                              (20)         (31)         (33)         (21)                                   
      Odontoma                                         1 (5%)                                 1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Adventitia, Alveolar/Bronchiolar                                                                                       
          Carcinoma, Metastatic, Lung                  1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Liver                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma, Metastatic, Skeletal Muscle     1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Skin           1 (2%)                                                                       
   Lymph Node                                         (1)          (1)          (3)          (5)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (100%)                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (48)         (50)         (49)         (47)                                   
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (48)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)                                             
   Thymus                                             (46)         (48)         (46)         (47)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Skin           1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Hemangiosarcoma                                  1 (100%)                                                                     
      Hemangiosarcoma, Metastatic, Spleen                           1 (100%)                                                        
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    10 (20%)      9 (18%)      4 (8%)       8 (16%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           4 (8%)       2 (4%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                    2 (4%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Mediastinum, Alveolus, Alveolar/Bronchiolar                                                                                   
          Carcinoma, Metastatic, Lung                  1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          6 (12%)      6 (12%)      4 (8%)       4 (8%)                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant                               2 (4%)                    2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 06/24/03  
Route: DOSED FEED                                                                                                 Time: 08:31:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          30          34          35                                       
     Total Primary Neoplasms                           52          46          52          52                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27          23          30          27                                       
     Total Benign Neoplasms                            34          36          40          39                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          10          11          13                                       
     Total Malignant Neoplasms                         18          10          12          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           5           3           3                                       
     Total Metastatic Neoplasm                         11           7           3           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.