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TDMS Study 88138-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 06/24/03       
EXPERIMENT: 88138 TEST: 04                                                                                     TIME: 08:31:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 06/24/03       
EXPERIMENT: 88138 TEST: 04                                                                                     TIME: 08:31:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 06/24/03       
EXPERIMENT: 88138 TEST: 04                                                                                     TIME: 08:31:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                      BENZOPHENONE                                                                                
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatoblastoma                                                                               
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
All Organs                             Malignant Tumors                                                                             
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
Uterus                                 Polyp Stromal                                                                                
                                       Sarcoma Stromal or Polyp Stromal                                                             
All Organs                             Histiocytic Sarcoma                                                                          
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                       BENZOPHENONE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |1/46.52      1/46.76      0/46.69      2/42.51      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.1%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |1/40 (3%)    1/42 (2%)    0/41 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.287      P=0.751N     P=0.495N     P=0.411      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.346      P=0.759N     P=0.499N     P=0.469      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.352      P=0.760N     P=0.500N     P=0.478      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.341      P=0.758N     P=0.498N     P=0.457      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.287      P=0.751N     (e)          P=0.411      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.360      P=0.753N     P=0.500N     P=0.492      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.238      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   4/50 (8%)    4/50 (8%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/48.36      6/47.66      4/48.93      4/48.51     |1/46.52      3/46.76      2/46.69      3/44.33      | 
|POLY-3 PERCENT (g) |     12.4%        12.6%        8.2%         8.3%        |2.2%         6.4%         4.3%         6.8%         | 
|TERMINAL (d)       |     4/44 (9%)    5/44 (11%)   2/44 (5%)    4/45 (9%)   |1/40 (3%)    3/42 (7%)    2/41 (5%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     652          606          585          730 (T)     |729 (T)      729 (T)      729 (T)      536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.254N     P=0.611      P=0.371N     P=0.360N    |P=0.217      P=0.323      P=0.509      P=0.257      | 
|POLY 3             |     P=0.258N     P=0.610      P=0.363N     P=0.368N    |P=0.281      P=0.307      P=0.501      P=0.288      | 
|POLY 1.5           |     P=0.259N     P=0.614      P=0.365N     P=0.368N    |P=0.289      P=0.306      P=0.499      P=0.294      | 
|POLY 6             |     P=0.259N     P=0.605      P=0.363N     P=0.371N    |P=0.272      P=0.309      P=0.503      P=0.281      | 
|LOGISTIC REGRESSION|     P=0.279N     P=0.615N     P=0.403N     P=0.371N    |P=0.305      P=0.323      P=0.509      P=0.345      | 
|COCH-ARM / FISHERS |     P=0.262N     P=0.620N     P=0.370N     P=0.370N    |P=0.302      P=0.309      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.390N     (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   4/50 (8%)    4/50 (8%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     7/48.47      7/47.66      4/48.93      4/48.51     |1/46.52      3/46.76      2/46.69      4/44.33      | 
|POLY-3 PERCENT (g) |     14.4%        14.7%        8.2%         8.3%        |2.2%         6.4%         4.3%         9.0%         | 
|TERMINAL (d)       |     4/44 (9%)    6/44 (14%)   2/44 (5%)    4/45 (9%)   |1/40 (3%)    3/42 (7%)    2/41 (5%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     652          606          585          730 (T)     |729 (T)      729 (T)      729 (T)      536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157N     P=0.602      P=0.268N     P=0.257N    |P=0.098      P=0.323      P=0.509      P=0.136      | 
|POLY 3             |     P=0.158N     P=0.600      P=0.257N     P=0.261N    |P=0.147      P=0.307      P=0.501      P=0.164      | 
|POLY 1.5           |     P=0.158N     P=0.605      P=0.258N     P=0.261N    |P=0.153      P=0.306      P=0.499      P=0.170      | 
|POLY 6             |     P=0.159N     P=0.592      P=0.258N     P=0.265N    |P=0.141      P=0.309      P=0.503      P=0.158      | 
|LOGISTIC REGRESSION|     P=0.172N     P=0.608N     P=0.290N     P=0.265N    |P=0.160      P=0.323      P=0.509      P=0.198      | 
|COCH-ARM / FISHERS |     P=0.160N     P=0.613N     P=0.262N     P=0.262N    |P=0.162      P=0.309      P=0.500      P=0.181      | 
|ORDER RESTRICTED   |     P=0.258N     (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      1/48.44      0/48.51     |1/46.52      0/46.76      3/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         0.0%        |2.2%         0.0%         6.4%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |1/40 (3%)    0/42 (0%)    3/41 (7%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          722          ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.697      (e)          P=0.504      (e)         |P=0.580N     P=0.490N     P=0.314      P=0.551N     | 
|POLY 3             |     P=0.700      (e)          P=0.502      (e)         |P=0.533N     P=0.499N     P=0.307      P=0.514N     | 
|POLY 1.5           |     P=0.698      (e)          P=0.502      (e)         |P=0.520N     P=0.500N     P=0.305      P=0.508N     | 
|POLY 6             |     P=0.702      (e)          P=0.502      (e)         |P=0.549N     P=0.498N     P=0.309      P=0.520N     | 
|LOGISTIC REGRESSION|     P=0.696      (e)          P=0.501      (e)         |P=0.580N     (e)          P=0.314      (e)          | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.500N     P=0.500N     P=0.309      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.282N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      1/48.44      0/48.51     |1/46.52      0/46.76      3/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         0.0%        |2.2%         0.0%         6.4%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |1/40 (3%)    0/42 (0%)    3/41 (7%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          722          ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.697      (e)          P=0.504      (e)         |P=0.580N     P=0.490N     P=0.314      P=0.551N     | 
|POLY 3             |     P=0.700      (e)          P=0.502      (e)         |P=0.533N     P=0.499N     P=0.307      P=0.514N     | 
|POLY 1.5           |     P=0.698      (e)          P=0.502      (e)         |P=0.520N     P=0.500N     P=0.305      P=0.508N     | 
|POLY 6             |     P=0.702      (e)          P=0.502      (e)         |P=0.549N     P=0.498N     P=0.309      P=0.520N     | 
|LOGISTIC REGRESSION|     P=0.696      (e)          P=0.501      (e)         |P=0.580N     (e)          P=0.314      (e)          | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.500N     P=0.500N     P=0.309      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.282N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      1/47.23      1/48.41      3/48.94     |0/46.52      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.1%         6.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    1/44 (2%)    1/44 (2%)    2/45 (4%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      606         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058      P=0.500      P=0.500      P=0.127     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.057      P=0.497      P=0.502      P=0.123     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.056      P=0.498      P=0.501      P=0.122     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.058      P=0.496      P=0.502      P=0.124     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.047 *    P=0.500      P=0.500      P=0.092     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.054      P=0.500      P=0.500      P=0.121     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.039 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  15/50 (30%)  23/50 (46%)  23/50 (46%) |5/50 (10%)   4/50 (8%)    10/50 (20%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     11/48.02     15/47.66     23/49.09     23/49.32    |5/46.52      4/46.95      10/46.69     8/44.20      | 
|POLY-3 PERCENT (g) |     22.9%        31.5%        46.9%        46.6%       |10.8%        8.5%         21.4%        18.1%        | 
|TERMINAL (d)       |     10/44 (23%)  14/44 (32%)  21/44 (48%)  21/45 (47%) |5/40 (13%)   3/42 (7%)    10/41 (24%)  7/31 (23%)   | 
|FIRST INCIDENCE    |     703          606          585          568         |729 (T)      680          729 (T)      435          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.248      P=0.011 *    P=0.014 *   |P=0.046 *    P=0.471N     P=0.139      P=0.143      | 
|POLY 3             |     P=0.006 **   P=0.239      P=0.010 *    P=0.011 *   |P=0.109      P=0.494N     P=0.131      P=0.243      | 
|POLY 1.5           |     P=0.005 **   P=0.242      P=0.010 *    P=0.010 *   |P=0.120      P=0.498N     P=0.129      P=0.256      | 
|POLY 6             |     P=0.007 **   P=0.236      P=0.011 *    P=0.012 *   |P=0.095      P=0.489N     P=0.133      P=0.225      | 
|LOGISTIC REGRESSION|     P=0.006 **   P=0.230      P=0.011 *    P=0.011 *   |P=0.107      P=0.494N     P=0.139      P=0.250      | 
|COCH-ARM / FISHERS |     P=0.005 **   P=0.247      P=0.010 *    P=0.010 *   |P=0.139      P=0.500N     P=0.131      P=0.277      | 
|ORDER RESTRICTED   |     P=0.009 **   (e)          (e)          (e)         |P=0.134      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   6/50 (12%)   6/50 (12%)  |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     8/48.51      5/48.70      6/48.60      6/48.93     |0/46.52      1/46.76      0/46.69      1/43.48      | 
|POLY-3 PERCENT (g) |     16.5%        10.3%        12.3%        12.3%       |0.0%         2.1%         0.0%         2.3%         | 
|TERMINAL (d)       |     7/44 (16%)   2/44 (5%)    5/44 (11%)   4/45 (9%)   |0/40 (0%)    1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     540          449          679          656         |---          729 (T)      ---          712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.385N     P=0.282N     P=0.387N     P=0.372N    |P=0.355      P=0.510      (e)          P=0.463      | 
|POLY 3             |     P=0.396N     P=0.274N     P=0.386N     P=0.381N    |P=0.389      P=0.501      (e)          P=0.487      | 
|POLY 1.5           |     P=0.398N     P=0.275N     P=0.386N     P=0.383N    |P=0.395      P=0.500      (e)          P=0.492      | 
|POLY 6             |     P=0.394N     P=0.273N     P=0.387N     P=0.377N    |P=0.381      P=0.502      (e)          P=0.480      | 
|LOGISTIC REGRESSION|     P=0.474N     P=0.228N     P=0.401N     P=0.414N    |P=0.384      P=0.510      (e)          P=0.488      | 
|COCH-ARM / FISHERS |     P=0.400N     P=0.277N     P=0.387N     P=0.387N    |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.378N     (e)          (e)          (e)         |P=0.239      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   6/50 (12%)   6/50 (12%)   9/50 (18%)  |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     8/48.51      6/48.70      6/48.60      9/49.35     |0/46.52      1/46.76      0/46.69      1/43.48      | 
|POLY-3 PERCENT (g) |     16.5%        12.3%        12.3%        18.2%       |0.0%         2.1%         0.0%         2.3%         | 
|TERMINAL (d)       |     7/44 (16%)   3/44 (7%)    5/44 (11%)   6/45 (13%)  |0/40 (0%)    1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     540          449          679          606         |---          729 (T)      ---          712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.404      P=0.390N     P=0.387N     P=0.520     |P=0.355      P=0.510      (e)          P=0.463      | 
|POLY 3             |     P=0.393      P=0.384N     P=0.386N     P=0.515     |P=0.389      P=0.501      (e)          P=0.487      | 
|POLY 1.5           |     P=0.388      P=0.385N     P=0.386N     P=0.509     |P=0.395      P=0.500      (e)          P=0.492      | 
|POLY 6             |     P=0.399      P=0.383N     P=0.387N     P=0.524     |P=0.381      P=0.502      (e)          P=0.480      | 
|LOGISTIC REGRESSION|     P=0.302      P=0.339N     P=0.401N     P=0.458     |P=0.384      P=0.510      (e)          P=0.488      | 
|COCH-ARM / FISHERS |     P=0.380      P=0.387N     P=0.387N     P=0.500     |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.421      (e)          (e)          (e)         |P=0.239      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  20/50 (40%)  25/50 (50%)  27/50 (54%) |5/50 (10%)   5/50 (10%)   10/50 (20%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     18/48.62     20/49.13     25/49.09     27/49.45    |5/46.52      5/46.95      10/46.69     9/44.27      | 
|POLY-3 PERCENT (g) |     37.0%        40.7%        50.9%        54.6%       |10.8%        10.7%        21.4%        20.3%        | 
|TERMINAL (d)       |     16/44 (36%)  16/44 (36%)  23/44 (52%)  24/45 (53%) |5/40 (13%)   4/42 (10%)   10/41 (24%)  7/31 (23%)   | 
|FIRST INCIDENCE    |     540          449          585          568         |729 (T)      680          729 (T)      435          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.048 *    P=0.422      P=0.121      P=0.076     |P=0.031 *    P=0.601N     P=0.139      P=0.090      | 
|POLY 3             |     P=0.034 *    P=0.434      P=0.118      P=0.060     |P=0.081      P=0.624N     P=0.131      P=0.165      | 
|POLY 1.5           |     P=0.033 *    P=0.429      P=0.116      P=0.057     |P=0.089      P=0.627N     P=0.129      P=0.176      | 
|POLY 6             |     P=0.036 *    P=0.441      P=0.118      P=0.063     |P=0.070      P=0.619N     P=0.133      P=0.151      | 
|LOGISTIC REGRESSION|     P=0.027 *    P=0.436      P=0.115      P=0.054     |P=0.077      P=0.625N     P=0.139      P=0.170      | 
|COCH-ARM / FISHERS |     P=0.030 *    P=0.418      P=0.113      P=0.054     |P=0.105      P=0.630N     P=0.131      P=0.194      | 
|ORDER RESTRICTED   |     P=0.057      (e)          (e)          (e)         |P=0.144      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  20/50 (40%)  25/50 (50%)  29/50 (58%) |5/50 (10%)   5/50 (10%)   10/50 (20%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     18/48.62     20/49.13     25/49.09     29/49.88    |5/46.52      5/46.95      10/46.69     9/44.27      | 
|POLY-3 PERCENT (g) |     37.0%        40.7%        50.9%        58.1%       |10.8%        10.7%        21.4%        20.3%        | 
|TERMINAL (d)       |     16/44 (36%)  16/44 (36%)  23/44 (52%)  25/45 (56%) |5/40 (13%)   4/42 (10%)   10/41 (24%)  7/31 (23%)   | 
|FIRST INCIDENCE    |     540          449          585          568         |729 (T)      680          729 (T)      435          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020 *    P=0.422      P=0.121      P=0.038 *   |P=0.031 *    P=0.601N     P=0.139      P=0.090      | 
|POLY 3             |     P=0.013 *    P=0.434      P=0.118      P=0.027 *   |P=0.081      P=0.624N     P=0.131      P=0.165      | 
|POLY 1.5           |     P=0.012 *    P=0.429      P=0.116      P=0.024 *   |P=0.089      P=0.627N     P=0.129      P=0.176      | 
|POLY 6             |     P=0.015 *    P=0.441      P=0.118      P=0.030 *   |P=0.070      P=0.619N     P=0.133      P=0.151      | 
|LOGISTIC REGRESSION|     P=0.009 **   P=0.436      P=0.115      P=0.021 *   |P=0.077      P=0.625N     P=0.139      P=0.170      | 
|COCH-ARM / FISHERS |     P=0.011 *    P=0.418      P=0.113      P=0.022 *   |P=0.105      P=0.630N     P=0.131      P=0.194      | 
|ORDER RESTRICTED   |     P=0.023 *    (e)          (e)          (e)         |P=0.144      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  11/50 (22%)  6/50 (12%)   9/50 (18%)  |0/50 (0%)    5/50 (10%)   2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     14/48.07     11/48.05     6/48.44      9/48.51     |0/46.52      5/47.68      2/46.69      3/43.73      | 
|POLY-3 PERCENT (g) |     29.1%        22.9%        12.4%        18.6%       |0.0%         10.5%        4.3%         6.9%         | 
|TERMINAL (d)       |     13/44 (30%)  9/44 (21%)   5/44 (11%)   9/45 (20%)  |0/40 (0%)    4/42 (10%)   2/41 (5%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     690          606          722          730 (T)     |---          316          729 (T)      672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.108N     P=0.330N     P=0.042N*    P=0.156N    |P=0.207      P=0.038 *    P=0.244      P=0.095      | 
|POLY 3             |     P=0.110N     P=0.322N     P=0.036N*    P=0.163N    |P=0.260      P=0.033 *    P=0.238      P=0.108      | 
|POLY 1.5           |     P=0.111N     P=0.323N     P=0.037N*    P=0.166N    |P=0.271      P=0.032 *    P=0.237      P=0.112      | 
|POLY 6             |     P=0.110N     P=0.320N     P=0.036N*    P=0.163N    |P=0.247      P=0.033 *    P=0.239      P=0.103      | 
|LOGISTIC REGRESSION|     P=0.108N     P=0.330N     P=0.037N*    P=0.158N    |P=0.321      P=0.032 *    P=0.244      P=0.115      | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.322N     P=0.039N*    P=0.171N    |P=0.292      P=0.028 *    P=0.247      P=0.121      | 
|ORDER RESTRICTED   |     P=0.072N     (e)          (e)          (e)         |P=0.100      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/48.11      0/47.23      1/48.41      0/48.51     |1/46.93      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         2.1%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/44 (2%)    0/44 (0%)    1/44 (2%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     679          ---          730 (T)      ---         |610          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187N     P=0.245N     P=0.500N     P=0.237N    |P=0.310N     P=0.500N     P=0.496N     P=0.509N     | 
|POLY 3             |     P=0.185N     P=0.241N     P=0.498N     P=0.235N    |P=0.297N     P=0.501N     P=0.501N     P=0.516N     | 
|POLY 1.5           |     P=0.186N     P=0.240N     P=0.498N     P=0.236N    |P=0.301N     P=0.501N     P=0.501N     P=0.509N     | 
|POLY 6             |     P=0.184N     P=0.244N     P=0.499N     P=0.236N    |P=0.292N     P=0.501N     P=0.501N     P=0.523N     | 
|LOGISTIC REGRESSION|     P=0.191N     P=0.233N     P=0.507N     P=0.248N    |P=0.274N     P=0.480N     P=0.464N     P=0.442N     | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.247N     P=0.500N     P=0.247N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.073N     (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  11/50 (22%)  7/50 (14%)   9/50 (18%)  |1/50 (2%)    5/50 (10%)   2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     16/48.27     11/48.05     7/48.44      9/48.51     |1/46.93      5/47.68      2/46.69      3/43.73      | 
|POLY-3 PERCENT (g) |     33.2%        22.9%        14.5%        18.6%       |2.1%         10.5%        4.3%         6.9%         | 
|TERMINAL (d)       |     14/44 (32%)  9/44 (21%)   6/44 (14%)   9/45 (20%)  |0/40 (0%)    4/42 (10%)   2/41 (5%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     679          606          722          730 (T)     |610          316          729 (T)      672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058N     P=0.196N     P=0.032N*    P=0.077N    |P=0.342      P=0.115      P=0.508      P=0.260      | 
|POLY 3             |     P=0.057N     P=0.186N     P=0.025N*    P=0.078N    |P=0.396      P=0.105      P=0.498      P=0.280      | 
|POLY 1.5           |     P=0.058N     P=0.185N     P=0.026N*    P=0.079N    |P=0.411      P=0.105      P=0.498      P=0.290      | 
|POLY 6             |     P=0.058N     P=0.186N     P=0.026N*    P=0.079N    |P=0.378      P=0.105      P=0.498      P=0.269      | 
|LOGISTIC REGRESSION|     P=0.057N     P=0.188N     P=0.026N*    P=0.076N    |P=0.482      P=0.101      P=0.505      P=0.323      | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.184N     P=0.028N*    P=0.083N    |P=0.438      P=0.102      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.032N*    (e)          (e)          (e)         |P=0.245      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    3/50 (6%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/46.42      3/46.76      3/46.69      2/43.51      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         6.4%         6.4%         4.6%         | 
|TERMINAL (d)       |                                                        |0/40 (0%)    3/42 (7%)    3/41 (7%)    1/31 (3%)    | 
|FIRST INCIDENCE    |                                                        |708          729 (T)      729 (T)      705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.363      P=0.318      P=0.309      P=0.422      | 
|POLY 3             |                                                        |P=0.433      P=0.308      P=0.307      P=0.477      | 
|POLY 1.5           |                                                        |P=0.452      P=0.309      P=0.308      P=0.488      | 
|POLY 6             |                                                        |P=0.411      P=0.308      P=0.308      P=0.465      | 
|LOGISTIC REGRESSION|                                                        |P=0.420      P=0.308      P=0.308      P=0.479      | 
|COCH-ARM / FISHERS |                                                        |P=0.484      P=0.316      P=0.316      P=0.508      | 
|ORDER RESTRICTED   |                                                        |P=0.338      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    2/49 (4%)    3/47 (6%)    | 
|POLY-3 RATE (b)    |     0/45.92      0/46.80      0/48.41      0/48.51     |2/46.52      0/46.76      2/45.69      3/41.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         4.4%         7.2%         | 
|TERMINAL (d)       |     0/42 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |2/40 (5%)    0/42 (0%)    2/40 (5%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          729 (T)      672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.165      P=0.228N     P=0.695      P=0.411      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.202      P=0.236N     P=0.687      P=0.451      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.207      P=0.237N     P=0.685      P=0.459      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.196      P=0.235N     P=0.689      P=0.441      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.204      (e)          P=0.695      P=0.463      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.215      P=0.247N     P=0.684      P=0.470      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.176      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |1/46.60      1/46.76      4/47.76      2/43.61      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.1%         8.4%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    1/42 (2%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |709          729 (T)      204          704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.242      P=0.755N     P=0.185      P=0.433      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.275      P=0.760N     P=0.187      P=0.477      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.289      P=0.760N     P=0.184      P=0.486      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.258      P=0.759N     P=0.189      P=0.466      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.371      P=0.761N     P=0.206      P=0.487      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.313      P=0.753N     P=0.181      P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.245      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |1/46.60      0/46.76      4/47.76      1/43.52      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         8.4%         2.3%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |709          ---          204          704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.379      P=0.500N     P=0.185      P=0.718      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.397      P=0.499N     P=0.187      P=0.745      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.415      P=0.500N     P=0.184      P=0.751      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.375      P=0.499N     P=0.189      P=0.738      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.519      P=0.500N     P=0.206      P=0.755      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.444      P=0.500N     P=0.181      P=0.753N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.188      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |1/46.60      0/46.76      4/47.76      2/43.61      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         8.4%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |709          ---          204          704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.182      P=0.500N     P=0.185      P=0.433      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.204      P=0.499N     P=0.187      P=0.477      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.216      P=0.500N     P=0.184      P=0.486      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.190      P=0.499N     P=0.189      P=0.466      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.294      P=0.500N     P=0.206      P=0.487      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.237      P=0.500N     P=0.181      P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.136      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.66      0/47.23      0/48.41      0/48.51     |1/46.52      2/47.39      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |2.2%         4.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |1/40 (3%)    1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     463          ---          ---          ---         |729 (T)      522          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.306N     P=0.504N     P=0.500N     P=0.500N    |P=0.215N     P=0.514      P=0.495N     P=0.551N     | 
|POLY 3             |     P=0.303N     P=0.506N     P=0.501N     P=0.501N    |P=0.194N     P=0.506      P=0.499N     P=0.514N     | 
|POLY 1.5           |     P=0.304N     P=0.504N     P=0.501N     P=0.500N    |P=0.192N     P=0.503      P=0.500N     P=0.508N     | 
|POLY 6             |     P=0.302N     P=0.508N     P=0.502N     P=0.501N    |P=0.196N     P=0.510      P=0.498N     P=0.520N     | 
|LOGISTIC REGRESSION|     P=0.769N     P=0.433N     (e)          (e)         |P=0.167N     P=0.508      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.121N     (e)          (e)          (e)         |P=0.185N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    4/50 (8%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.92      3/47.23      4/48.59      0/48.51     |2/46.52      0/46.76      2/46.78      1/43.42      | 
|POLY-3 PERCENT (g) |     2.1%         6.4%         8.2%         0.0%        |4.3%         0.0%         4.3%         2.3%         | 
|TERMINAL (d)       |     1/44 (2%)    3/44 (7%)    3/44 (7%)    0/45 (0%)   |2/40 (5%)    0/42 (0%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      683          ---         |729 (T)      ---          704          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.305N     P=0.305      P=0.182      P=0.496N    |P=0.613N     P=0.228N     P=0.689N     P=0.589N     | 
|POLY 3             |     P=0.304N     P=0.300      P=0.183      P=0.498N    |P=0.551N     P=0.236N     P=0.692N     P=0.524N     | 
|POLY 1.5           |     P=0.306N     P=0.303      P=0.182      P=0.498N    |P=0.543N     P=0.237N     P=0.693      P=0.515N     | 
|POLY 6             |     P=0.302N     P=0.298      P=0.184      P=0.497N    |P=0.560N     P=0.235N     P=0.689N     P=0.536N     | 
|LOGISTIC REGRESSION|     P=0.306N     P=0.305      P=0.180      (e)         |P=0.574N     (e)          P=0.693N     P=0.589N     | 
|COCH-ARM / FISHERS |     P=0.313N     P=0.309      P=0.181      P=0.500N    |P=0.531N     P=0.247N     P=0.691N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.130N     (e)          (e)          (e)         |P=0.431N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.92      3/47.23      3/48.41      0/48.51     |1/46.52      0/46.76      2/46.78      1/43.42      | 
|POLY-3 PERCENT (g) |     2.1%         6.4%         6.2%         0.0%        |2.2%         0.0%         4.3%         2.3%         | 
|TERMINAL (d)       |     1/44 (2%)    3/44 (7%)    3/44 (7%)    0/45 (0%)   |1/40 (3%)    0/42 (0%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      ---         |729 (T)      ---          704          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.272N     P=0.305      P=0.305      P=0.496N    |P=0.428      P=0.490N     P=0.503      P=0.704      | 
|POLY 3             |     P=0.272N     P=0.300      P=0.309      P=0.498N    |P=0.467      P=0.499N     P=0.502      P=0.745      | 
|POLY 1.5           |     P=0.274N     P=0.303      P=0.308      P=0.498N    |P=0.480      P=0.500N     P=0.500      P=0.751      | 
|POLY 6             |     P=0.271N     P=0.298      P=0.309      P=0.497N    |P=0.451      P=0.498N     P=0.505      P=0.737      | 
|LOGISTIC REGRESSION|     P=0.272N     P=0.305      P=0.305      (e)         |P=0.466      (e)          P=0.502      P=0.704      | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.309      P=0.309      P=0.500N    |P=0.500      P=0.500N     P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.154N     (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      1/47.30      2/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.1%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          561          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.648      P=0.500      P=0.244      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.644N     P=0.503      P=0.238      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.633N     P=0.502      P=0.237      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.630      P=0.505      P=0.239      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.594N     P=0.539      P=0.244      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.616N     P=0.500      P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.327      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.92      0/47.23      1/48.41      0/48.51     |0/46.52      1/47.30      2/46.69      1/44.02      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.1%         0.0%        |0.0%         2.1%         4.3%         2.3%         | 
|TERMINAL (d)       |     1/44 (2%)    0/44 (0%)    1/44 (2%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          730 (T)      ---         |---          561          729 (T)      536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.401N     P=0.500N     P=0.762      P=0.496N    |P=0.320      P=0.500      P=0.244      P=0.492      | 
|POLY 3             |     P=0.401N     P=0.503N     P=0.758N     P=0.498N    |P=0.338      P=0.503      P=0.238      P=0.489      | 
|POLY 1.5           |     P=0.403N     P=0.502N     P=0.759N     P=0.498N    |P=0.349      P=0.502      P=0.237      P=0.493      | 
|POLY 6             |     P=0.400N     P=0.504N     P=0.758N     P=0.497N    |P=0.324      P=0.505      P=0.239      P=0.484      | 
|LOGISTIC REGRESSION|     P=0.401N     (e)          P=0.762      (e)         |P=0.418      P=0.539      P=0.244      P=0.615      | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.753N     P=0.500N    |P=0.366      P=0.500      P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.249N     (e)          (e)          (e)         |P=0.226      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |4/46.52      1/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |                                                        |8.6%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |4/40 (10%)   1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.025N*    P=0.165N     P=0.060N     P=0.099N     | 
|POLY 3             |                                                        |P=0.019N*    P=0.177N     P=0.060N     P=0.070N     | 
|POLY 1.5           |                                                        |P=0.018N*    P=0.179N     P=0.061N     P=0.066N     | 
|POLY 6             |                                                        |P=0.019N*    P=0.176N     P=0.059N     P=0.074N     | 
|LOGISTIC REGRESSION|                                                        |P=0.025N*    P=0.165N     (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.019N*    P=0.181N     P=0.059N     P=0.059N     | 
|ORDER RESTRICTED   |                                                        |P=0.008N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |5/46.60      1/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |                                                        |10.7%        2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |4/40 (10%)   1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |                                                        |709          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.012N*    P=0.096N     P=0.033N*    P=0.060N     | 
|POLY 3             |                                                        |P=0.008N**   P=0.101N     P=0.030N*    P=0.037N*    | 
|POLY 1.5           |                                                        |P=0.008N**   P=0.102N     P=0.031N*    P=0.034N*    | 
|POLY 6             |                                                        |P=0.008N**   P=0.100N     P=0.030N*    P=0.040N*    | 
|LOGISTIC REGRESSION|                                                        |P=0.010N*    P=0.100N     P=0.032N*    P=0.046N*    | 
|COCH-ARM / FISHERS |                                                        |P=0.009N**   P=0.102N     P=0.028N*    P=0.028N*    | 
|ORDER RESTRICTED   |                                                        |P=0.002N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      2/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    2/42 (5%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.455N     P=0.249      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.413N     P=0.238      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.410N     P=0.238      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.417N     P=0.239      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.249      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.261N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/48.40      2/47.62      1/48.41      0/48.51     |1/46.60      0/46.76      2/46.80      2/44.04      | 
|POLY-3 PERCENT (g) |     6.2%         4.2%         2.1%         0.0%        |2.2%         0.0%         4.3%         4.5%         | 
|TERMINAL (d)       |     1/44 (2%)    1/44 (2%)    1/44 (2%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     652          620          730 (T)      ---         |708          ---          700          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062N     P=0.513N     P=0.308N     P=0.123N    |P=0.199      P=0.505N     P=0.497      P=0.449      | 
|POLY 3             |     P=0.061N     P=0.507N     P=0.306N     P=0.119N    |P=0.227      P=0.499N     P=0.501      P=0.480      | 
|POLY 1.5           |     P=0.061N     P=0.504N     P=0.305N     P=0.119N    |P=0.234      P=0.500N     P=0.500      P=0.487      | 
|POLY 6             |     P=0.061N     P=0.511N     P=0.308N     P=0.119N    |P=0.219      P=0.499N     P=0.504      P=0.472      | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.477N     P=0.332N     P=0.139N    |P=0.260      P=0.500N     P=0.500      P=0.537      | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.500N     P=0.309N     P=0.121N    |P=0.245      P=0.500N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.057N     (e)          (e)          (e)         |P=0.250      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/48.40      2/47.62      1/48.41      0/48.51     |1/46.60      2/46.76      2/46.80      2/44.04      | 
|POLY-3 PERCENT (g) |     6.2%         4.2%         2.1%         0.0%        |2.2%         4.3%         4.3%         4.5%         | 
|TERMINAL (d)       |     1/44 (2%)    1/44 (2%)    1/44 (2%)    0/45 (0%)   |0/40 (0%)    2/42 (5%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     652          620          730 (T)      ---         |708          729 (T)      700          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062N     P=0.513N     P=0.308N     P=0.123N    |P=0.346      P=0.509      P=0.497      P=0.449      | 
|POLY 3             |     P=0.061N     P=0.507N     P=0.306N     P=0.119N    |P=0.395      P=0.501      P=0.501      P=0.480      | 
|POLY 1.5           |     P=0.061N     P=0.504N     P=0.305N     P=0.119N    |P=0.405      P=0.500      P=0.500      P=0.487      | 
|POLY 6             |     P=0.061N     P=0.511N     P=0.308N     P=0.119N    |P=0.384      P=0.502      P=0.504      P=0.472      | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.477N     P=0.332N     P=0.139N    |P=0.428      P=0.503      P=0.500      P=0.537      | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.500N     P=0.309N     P=0.121N    |P=0.423      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.057N     (e)          (e)          (e)         |P=0.442      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      0/46.76      5/46.73      3/43.70      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |0.0%         0.0%         10.7%        6.9%         | 
|TERMINAL (d)       |     1/44 (2%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    4/41 (10%)   2/31 (7%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          ---          ---         |---          ---          718          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.304N     P=0.500N     P=0.500N     P=0.496N    |P=0.021 *    (e)          P=0.037 *    P=0.091      | 
|POLY 3             |     P=0.305N     P=0.503N     P=0.498N     P=0.498N    |P=0.032 *    (e)          P=0.031 *    P=0.108      | 
|POLY 1.5           |     P=0.306N     P=0.502N     P=0.499N     P=0.498N    |P=0.035 *    (e)          P=0.031 *    P=0.112      | 
|POLY 6             |     P=0.305N     P=0.504N     P=0.498N     P=0.497N    |P=0.028 *    (e)          P=0.031 *    P=0.103      | 
|LOGISTIC REGRESSION|     P=0.304N     (e)          (e)          (e)         |P=0.034 *    (e)          P=0.034 *    P=0.114      | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.044 *    (e)          P=0.028 *    P=0.121      | 
|ORDER RESTRICTED   |     P=0.118N     (e)          (e)          (e)         |P=0.026 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    3/50 (6%)   |8/50 (16%)   9/50 (18%)   5/50 (10%)   10/50 (20%)  | 
|POLY-3 RATE (b)    |     2/48.07      0/47.23      2/48.41      3/48.63     |8/47.74      9/47.68      5/46.99      10/45.12     | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         4.1%         6.2%        |16.8%        18.9%        10.6%        22.2%        | 
|TERMINAL (d)       |     1/44 (2%)    0/44 (0%)    2/44 (5%)    2/45 (4%)   |5/40 (13%)   6/42 (14%)   4/41 (10%)   5/31 (16%)   | 
|FIRST INCIDENCE    |     690          ---          730 (T)      700         |414          522          645          435          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.248      P=0.242N     P=0.691      P=0.510     |P=0.241      P=0.531      P=0.269N     P=0.260      | 
|POLY 3             |     P=0.245      P=0.241N     P=0.691N     P=0.505     |P=0.352      P=0.499      P=0.286N     P=0.347      | 
|POLY 1.5           |     P=0.242      P=0.240N     P=0.691N     P=0.504     |P=0.367      P=0.497      P=0.286N     P=0.364      | 
|POLY 6             |     P=0.247      P=0.243N     P=0.692N     P=0.506     |P=0.335      P=0.504      P=0.285N     P=0.328      | 
|LOGISTIC REGRESSION|     P=0.239      P=0.236N     P=0.694N     P=0.495     |P=0.438      P=0.501      P=0.268N     P=0.460      | 
|COCH-ARM / FISHERS |     P=0.237      P=0.247N     P=0.691N     P=0.500     |P=0.397      P=0.500      P=0.277N     P=0.398      | 
|ORDER RESTRICTED   |     P=0.224      (e)          (e)          (e)         |P=0.311      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  23/50 (46%)  30/50 (60%)  27/50 (54%) |15/50 (30%)  17/50 (34%)  19/50 (38%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     27/48.47     23/48.05     30/49.12     27/49.32    |15/46.60     17/47.86     19/46.78     19/46.69     | 
|POLY-3 PERCENT (g) |     55.7%        47.9%        61.1%        54.8%       |32.2%        35.5%        40.6%        40.7%        | 
|TERMINAL (d)       |     24/44 (55%)  21/44 (48%)  27/44 (61%)  25/45 (56%) |14/40 (35%)  15/42 (36%)  18/41 (44%)  10/31 (32%)  | 
|FIRST INCIDENCE    |     652          606          585          568         |708          316          704          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.450      P=0.288N     P=0.353      P=0.531N    |P=0.050      P=0.475      P=0.285      P=0.097      | 
|POLY 3             |     P=0.446      P=0.285N     P=0.370      P=0.543N    |P=0.214      P=0.451      P=0.264      P=0.261      | 
|POLY 1.5           |     P=0.429      P=0.281N     P=0.363      P=0.554N    |P=0.218      P=0.439      P=0.259      P=0.262      | 
|POLY 6             |     P=0.456      P=0.292N     P=0.370      P=0.537N    |P=0.207      P=0.462      P=0.270      P=0.257      | 
|LOGISTIC REGRESSION|     P=0.430      P=0.296N     P=0.365      P=0.558N    |P=0.204      P=0.417      P=0.267      P=0.264      | 
|COCH-ARM / FISHERS |     P=0.396      P=0.274N     P=0.343      P=0.579N    |P=0.226      P=0.415      P=0.263      P=0.263      | 
|ORDER RESTRICTED   |     P=0.429      (e)          (e)          (e)         |P=0.314      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/24/03                           EXPERIMENT: 88138 TEST: 04                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                       BENZOPHENONE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  10/50 (20%)  11/50 (22%)  13/50 (26%) |16/50 (32%)  13/50 (26%)  19/50 (38%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     17/50.00     10/49.09     11/48.78     13/49.47    |16/48.40     13/48.55     19/48.95     21/46.29     | 
|POLY-3 PERCENT (g) |     34.0%        20.4%        22.6%        26.3%       |33.1%        26.8%        38.8%        45.4%        | 
|TERMINAL (d)       |     11/44 (25%)  6/44 (14%)   9/44 (21%)   9/45 (20%)  |9/40 (23%)   8/42 (19%)   13/41 (32%)  10/31 (32%)  | 
|FIRST INCIDENCE    |     463          449          679          606         |414          522          204          435          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.310N     P=0.113N     P=0.152N     P=0.258N    |P=0.029 *    P=0.313N     P=0.375      P=0.091      | 
|POLY 3             |     P=0.326N     P=0.097N     P=0.150N     P=0.269N    |P=0.064      P=0.326N     P=0.352      P=0.154      | 
|POLY 1.5           |     P=0.324N     P=0.093N     P=0.142N     P=0.264N    |P=0.072      P=0.331N     P=0.348      P=0.169      | 
|POLY 6             |     P=0.328N     P=0.102N     P=0.160N     P=0.274N    |P=0.057      P=0.319N     P=0.354      P=0.143      | 
|LOGISTIC REGRESSION|     P=0.393N     P=0.045N*    P=0.147N     P=0.278N    |P=0.125      P=0.330N     P=0.336      P=0.226      | 
|COCH-ARM / FISHERS |     P=0.321N     P=0.088N     P=0.133N     P=0.257N    |P=0.091      P=0.330N     P=0.338      P=0.204      | 
|ORDER RESTRICTED   |     P=0.164N     (e)          (e)          (e)         |P=0.090      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/50 (76%)  30/50 (60%)  34/50 (68%)  35/50 (70%) |25/50 (50%)  28/50 (56%)  32/50 (64%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     38/50.00     30/49.52     34/49.30     35/50.00    |25/48.40     28/49.46     32/48.95     30/48.01     | 
|POLY-3 PERCENT (g) |     76.0%        60.6%        69.0%        70.0%       |51.7%        56.6%        65.4%        62.5%        | 
|TERMINAL (d)       |     32/44 (73%)  25/44 (57%)  30/44 (68%)  30/45 (67%) |18/40 (45%)  22/42 (52%)  26/41 (63%)  16/31 (52%)  | 
|FIRST INCIDENCE    |     463          449          585          568         |414          316          204          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413N     P=0.109N     P=0.285N     P=0.305N    |P=0.027 *    P=0.433      P=0.173      P=0.063      | 
|POLY 3             |     P=0.463N     P=0.074N     P=0.288N     P=0.327N    |P=0.145      P=0.387      P=0.119      P=0.191      | 
|POLY 1.5           |     P=0.466N     P=0.070N     P=0.272N     P=0.327N    |P=0.153      P=0.371      P=0.117      P=0.196      | 
|POLY 6             |     P=0.460N     P=0.079N     P=0.311N     P=0.327N    |P=0.141      P=0.402      P=0.119      P=0.191      | 
|LOGISTIC REGRESSION|     P=0.499N     P=0.056N     P=0.260N     (e)         |P=0.210      P=0.340      P=0.113      P=0.237      | 
|COCH-ARM / FISHERS |     P=0.470N     P=0.066N     P=0.252N     P=0.326N    |P=0.173      P=0.344      P=0.113      P=0.211      | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |P=0.170      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).