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TDMS Study 88138-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 06/01/04       
EXPERIMENT: 88138 TEST: 04                                                                                     TIME: 13:43:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#2 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 06/01/04       
EXPERIMENT: 88138 TEST: 04                                                                                     TIME: 13:43:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                      BENZOPHENONE                                                                                
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Harderian Gland                        Infiltration Cellular Lymphoid                                                               
Kidney                                 Metaplasia Osseous                                                                           
Kidney: Cortex                         Cyst                                                                                         
Liver                                  Clear Cell Focus                                                                             
                                       Infiltration Cellular Lymphoid                                                               
                                       Inflammation Chronic                                                                         
Liver: Hepatocyte                      Degeneration Cystic                                                                          
                                       Multinucleated                                                                               
                                       Necrosis                                                                                     
Liver: Hepatocyte, Centrilobular       Hypertrophy                                                                                  
Lung                                   Infiltration Cellular Lymphoid                                                               
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Nose: Olfactory Epithelium             Metaplasia                                                                                   
Preputial Gland                        Inflammation Chronic                                                                         
Preputial Gland: Duct                  Ectasia                                                                                      
Prostate                               Infiltration Cellular Lymphoid                                                               
Salivary Glands                        Infiltration Cellular Lymphoid                                                               
Spleen: Lymphoid Follicle              Hyperplasia Lymphoid                                                                         
Stomach, Glandular: Glands             Ectasia                                                                                      
Testes                                 Mineralization                                                                               
Thymus                                 Atrophy                                                                                      
                                       Ectopic Parathyroid Gland                                                                    
Thyroid Gland                          Inflammation Chronic                                                                         
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Hyperplasia                                                                                  
Adrenal Cortex: Subcapsular            Hyperplasia                                                                                  
Bone Marrow                            Myelofibrosis                                                                                
Brain                                  Hemorrhage                                                                                   
Clitoral Gland                         Inflammation Chronic                                                                         
Eye                                    Atrophy                                                                                      
Islets, Pancreatic                     Hyperplasia                                                                                  
Kidney                                 Mineralization                                                                               
                                       Nephropathy                                                                                  
Liver                                  Eosinophilic Focus                                                                           
                                       Inflammation Chronic                                                                         
Liver: Hepatocyte                      Multinucleated                                                                               
                                       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Liver: Hepatocyte, Centrilobular       Hypertrophy                                                                                  
Lung                                   Infiltration Cellular Lymphoid                                                               
                                       Pigmentation                                                                                 
Lymph Node, Mandibular                 Hyperplasia Lymphoid                                                                         
Mesentery: Fat                         Fibrosis                                                                                     
                                       Inflammation Chronic                                                                         
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 06/01/04       
EXPERIMENT: 88138 TEST: 04                                                                                     TIME: 13:43:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
                                       Necrosis                                                                                     
Nose: Olfactory Epithelium             Metaplasia                                                                                   
Ovary                                  Pigmentation                                                                                 
Pancreas                               Infiltration Cellular Lymphoid                                                               
Pituitary Gland: Pars Distalis         Cyst                                                                                         
                                       Hyperplasia                                                                                  
Skeletal Muscle                        Infiltration Cellular Lymphoid                                                               
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Hemorrhage                                                                                   
Spleen: Lymphoid Follicle              Hyperplasia Lymphoid                                                                         
Thymus                                 Atrophy                                                                                      
                                       Cyst                                                                                         
                                       Hyperplasia Lymphoid                                                                         
Thyroid Gland: Follicle                Degeneration                                                                                 
Urinary Bladder                        Infiltration Cellular Lymphoid                                                               
===============================================================                                                                     
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                       BENZOPHENONE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Fatty                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      2/48.41      0/48.51     |0/46.52      0/46.76      0/46.69      0/42.51      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.1%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    2/44 (5%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.599      (e)          P=0.238      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.604      (e)          P=0.240      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.601      (e)          P=0.239      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.606      (e)          P=0.240      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.238      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.249      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   10/50 (20%)  9/50 (18%)   6/50 (12%)  |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     7/47.92      10/47.72     9/48.41      6/48.51     |2/46.52      0/46.76      0/46.69      0/42.51      | 
|POLY-3 PERCENT (g) |     14.6%        21.0%        18.6%        12.4%       |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     7/44 (16%)   9/44 (21%)   9/44 (21%)   6/45 (13%)  |2/40 (5%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      585          730 (T)      730 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.328N     P=0.298      P=0.392      P=0.483N    |P=0.131N     P=0.228N     P=0.233N     P=0.296N     | 
|POLY 3             |     P=0.334N     P=0.294      P=0.401      P=0.490N    |P=0.113N     P=0.236N     P=0.236N     P=0.258N     | 
|POLY 1.5           |     P=0.339N     P=0.295      P=0.399      P=0.493N    |P=0.114N     P=0.237N     P=0.238N     P=0.252N     | 
|POLY 6             |     P=0.332N     P=0.293      P=0.402      P=0.489N    |P=0.111N     P=0.235N     P=0.235N     P=0.265N     | 
|LOGISTIC REGRESSION|     P=0.329N     P=0.287      P=0.392      P=0.483N    |P=0.131N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.348N     P=0.298      P=0.393      P=0.500N    |P=0.116N     P=0.247N     P=0.247N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.362N     (e)          (e)          (e)         |P=0.036N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  22/50 (44%)  24/50 (48%)  18/50 (36%) |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     26/48.02     22/47.23     24/48.44     18/48.51    |1/46.52      1/46.76      0/46.69      0/42.51      | 
|POLY-3 PERCENT (g) |     54.1%        46.6%        49.6%        37.1%       |2.2%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     25/44 (57%)  22/44 (50%)  23/44 (52%)  18/45 (40%) |1/40 (3%)    1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     703          730 (T)      722          730 (T)     |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061N     P=0.267N     P=0.418N     P=0.061N    |P=0.268N     P=0.751N     P=0.495N     P=0.551N     | 
|POLY 3             |     P=0.065N     P=0.296N     P=0.402N     P=0.067N    |P=0.241N     P=0.759N     P=0.499N     P=0.518N     | 
|POLY 1.5           |     P=0.071N     P=0.287N     P=0.407N     P=0.071N    |P=0.241N     P=0.760N     P=0.500N     P=0.513N     | 
|POLY 6             |     P=0.061N     P=0.308N     P=0.403N     P=0.065N    |P=0.241N     P=0.758N     P=0.498N     P=0.524N     | 
|LOGISTIC REGRESSION|     P=0.057N     P=0.286N     P=0.399N     P=0.060N    |P=0.268N     P=0.751N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.082N     P=0.274N     P=0.421N     P=0.079N    |P=0.238N     P=0.753N     P=0.500N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.066N     (e)          (e)          (e)         |P=0.270N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 46/50 (92%)  46/50 (92%)  47/50 (94%) |49/50 (98%)  49/50 (98%)  49/50 (98%)  49/49 (100%) | 
|POLY-3 RATE (b)    |     50/50.00     46/49.05     46/49.82     47/50.00    |49/49.18     49/49.08     49/49.85     49/49.00     | 
|POLY-3 PERCENT (g) |     100.0%       93.8%        92.3%        94.0%       |99.6%        99.8%        98.3%        100.0%       | 
|TERMINAL (d)       |     44/44 (100%) 42/44 (96%)  41/44 (93%)  42/45 (93%) |40/40 (100%) 42/42 (100%) 41/41 (100%) 31/31 (100%) | 
|FIRST INCIDENCE    |     463          449          585          568         |456          522          204          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.214N     P=0.201N     P=0.207N     P=0.206N    |P=0.007 **   P=0.400N     P=0.496N     P=0.035 *    | 
|POLY 3             |     P=0.158N     P=0.092N     P=0.064N     P=0.119N    |P=0.741      P=1.000      P=0.653N     P=1.000      | 
|POLY 1.5           |     P=0.181N     P=0.074N     P=0.062N     P=0.119N    |P=0.570      P=0.950      P=0.693N     P=0.909      | 
|POLY 6             |     P=0.134N     P=0.135N     P=0.069N     P=0.119N    |P=0.802N     P=1.000      P=0.671N     P=1.000      | 
|LOGISTIC REGRESSION|     P=0.181N     P=0.067N     P=0.062N     (e)         |P=0.183      (e)          P=0.708      P=0.252      | 
|COCH-ARM / FISHERS |     P=0.216N     P=0.059N     P=0.059N     P=0.121N    |P=0.316      P=0.753N     P=0.753N     P=0.505      | 
|ORDER RESTRICTED   |     P=0.077N     (e)          (e)          (e)         |P=0.436      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      1/47.23      0/48.41      0/48.51     |0/46.52      0/46.76      2/46.69      0/42.51      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    1/44 (2%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.563N     P=0.500      (e)          (e)         |P=0.544      (e)          P=0.244      (e)          | 
|POLY 3             |     P=0.567N     P=0.497      (e)          (e)         |P=0.549      (e)          P=0.238      (e)          | 
|POLY 1.5           |     P=0.567N     P=0.498      (e)          (e)         |P=0.566      (e)          P=0.237      (e)          | 
|POLY 6             |     P=0.568N     P=0.496      (e)          (e)         |P=0.527      (e)          P=0.239      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.500      (e)          (e)         |(e)          (e)          P=0.244      (e)          | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.591      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.376N     (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |18/50 (36%)  30/50 (60%)  20/50 (40%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     0/46.92      0/47.23      0/48.41      0/48.51     |18/47.02     30/47.38     20/46.69     26/46.34     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |38.3%        63.3%        42.8%        56.1%        | 
|TERMINAL (d)       |     0/43 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |16/40 (40%)  28/42 (67%)  20/41 (49%)  18/31 (58%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |606          561          729 (T)      344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.020 *    P=0.022 *    P=0.451      P=0.012 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.171      P=0.011 *    P=0.406      P=0.061      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.184      P=0.011 *    P=0.406      P=0.067      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.153      P=0.010 *    P=0.402      P=0.053      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.133      P=0.013 *    P=0.435      P=0.062      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.208      P=0.014 *    P=0.418      P=0.079      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.057      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      0/46.76      0/46.69      2/44.45      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.5%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.222      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.227      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.231      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.222      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.064      (e)          (e)          P=0.348      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.026 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      1/46.76      2/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.1%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    1/42 (2%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.635      P=0.510      P=0.244      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.643N     P=0.501      P=0.238      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.633N     P=0.500      P=0.237      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.631      P=0.502      P=0.239      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.510      P=0.244      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.616N     P=0.500      P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.327      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |8/50 (16%)   1/49 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |8/46.94      1/46.68      0/46.69      2/43.72      | 
|POLY-3 PERCENT (g) |                                                        |17.1%        2.1%         0.0%         4.6%         | 
|TERMINAL (d)       |                                                        |7/40 (18%)   1/42 (2%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |                                                        |608          729 (T)      ---          645          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.042N*    P=0.016N*    P=0.005N**   P=0.096N     | 
|POLY 3             |                                                        |P=0.024N*    P=0.016N*    P=0.004N**   P=0.058N     | 
|POLY 1.5           |                                                        |P=0.024N*    P=0.016N*    P=0.004N**   P=0.053N     | 
|POLY 6             |                                                        |P=0.024N*    P=0.016N*    P=0.004N**   P=0.064N     | 
|LOGISTIC REGRESSION|                                                        |P=0.027N*    P=0.018N*    P=0.005N**   P=0.054N     | 
|COCH-ARM / FISHERS |                                                        |P=0.026N*    P=0.017N*    P=0.003N**   P=0.046N*    | 
|ORDER RESTRICTED   |                                                        |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     1/47.92      2/47.62      2/48.41      1/48.51     |                                                    | 
|POLY-3 PERCENT (g) |     2.1%         4.2%         4.1%         2.1%        |                                                    | 
|TERMINAL (d)       |     1/44 (2%)    1/44 (2%)    2/44 (5%)    1/45 (2%)   |                                                    | 
|FIRST INCIDENCE    |     730 (T)      620          730 (T)      730 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.547N     P=0.495      P=0.500      P=0.757N    |                                                    | 
|POLY 3             |     P=0.549N     P=0.498      P=0.504      P=0.758N    |                                                    | 
|POLY 1.5           |     P=0.551N     P=0.499      P=0.503      P=0.758N    |                                                    | 
|POLY 6             |     P=0.548N     P=0.498      P=0.504      P=0.757N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.566N     P=0.512      P=0.500      P=0.757N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.500      P=0.500      P=0.753N    |                                                    | 
|ORDER RESTRICTED   |     P=0.542N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  27/50 (54%)  30/50 (60%)  31/50 (62%) |                                                    | 
|POLY-3 RATE (b)    |     32/49.14     27/49.48     30/48.82     31/49.47    |                                                    | 
|POLY-3 PERCENT (g) |     65.1%        54.6%        61.5%        62.7%       |                                                    | 
|TERMINAL (d)       |     29/44 (66%)  23/44 (52%)  27/44 (61%)  27/45 (60%) |                                                    | 
|FIRST INCIDENCE    |     463          449          679          606         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.517N     P=0.231N     P=0.422N     P=0.449N    |                                                    | 
|POLY 3             |     P=0.509      P=0.194N     P=0.434N     P=0.482N    |                                                    | 
|POLY 1.5           |     P=0.504      P=0.199N     P=0.427N     P=0.490N    |                                                    | 
|POLY 6             |     P=0.517      P=0.188N     P=0.444N     P=0.470N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.496      P=0.196N     P=0.399N     P=0.498N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.500      P=0.208N     P=0.418N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.451N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    4/50 (8%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      4/48.41      0/48.51     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.3%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    4/44 (9%)    0/45 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.507      (e)          P=0.063      (e)         |                                                    | 
|POLY 3             |     P=0.512      (e)          P=0.062      (e)         |                                                    | 
|POLY 1.5           |     P=0.508      (e)          P=0.062      (e)         |                                                    | 
|POLY 6             |     P=0.515      (e)          P=0.062      (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.063      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.500      (e)          P=0.059      (e)         |                                                    | 
|ORDER RESTRICTED   |     P=0.111      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |2/46.52      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |1/40 (3%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |728          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.133N     P=0.232N     P=0.237N     P=0.300N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.236N     P=0.236N     P=0.253N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.112N     P=0.237N     P=0.238N     P=0.247N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.110N     P=0.235N     P=0.235N     P=0.261N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.129N     P=0.234N     P=0.236N     P=0.291N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.035N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      1/47.66      2/48.93      1/48.51     |0/46.52      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         4.1%         2.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    1/45 (2%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          606          585          730 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.375      P=0.496      P=0.247      P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.373      P=0.499      P=0.242      P=0.502     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.371      P=0.499      P=0.240      P=0.502     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.375      P=0.499      P=0.243      P=0.503     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.264      P=0.527      P=0.151      P=0.504     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366      P=0.500      P=0.247      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.230      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    3/50 (6%)    3/50 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/47.92      3/47.23      3/48.41      2/48.51     |0/46.52      3/46.95      3/46.69      1/42.75      | 
|POLY-3 PERCENT (g) |     4.2%         6.4%         6.2%         4.1%        |0.0%         6.4%         6.4%         2.3%         | 
|TERMINAL (d)       |     2/44 (5%)    3/44 (7%)    3/44 (7%)    2/45 (4%)   |0/40 (0%)    2/42 (5%)    3/41 (7%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      730 (T)     |---          680          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.532N     P=0.500      P=0.500      P=0.686N    |P=0.426      P=0.130      P=0.126      P=0.449      | 
|POLY 3             |     P=0.535N     P=0.493      P=0.505      P=0.689N    |P=0.474      P=0.120      P=0.119      P=0.483      | 
|POLY 1.5           |     P=0.537N     P=0.496      P=0.503      P=0.690N    |P=0.490      P=0.120      P=0.119      P=0.488      | 
|POLY 6             |     P=0.533N     P=0.491      P=0.505      P=0.688N    |P=0.454      P=0.122      P=0.120      P=0.477      | 
|LOGISTIC REGRESSION|     P=0.532N     P=0.500      P=0.500      P=0.686N    |P=0.481      P=0.121      P=0.126      P=0.449      | 
|COCH-ARM / FISHERS |     P=0.544N     P=0.500      P=0.500      P=0.691N    |P=0.518      P=0.121      P=0.121      P=0.495      | 
|ORDER RESTRICTED   |     P=0.586N     (e)          (e)          (e)         |P=0.165      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/50 (74%)  33/50 (66%)  24/50 (48%)  29/50 (58%) |29/50 (58%)  27/50 (54%)  27/50 (54%)  23/49 (47%)  | 
|POLY-3 RATE (b)    |     37/49.41     33/50.00     24/48.44     29/49.22    |29/46.68     27/48.47     27/47.52     23/43.99     | 
|POLY-3 PERCENT (g) |     74.9%        66.0%        49.6%        58.9%       |62.1%        55.7%        56.8%        52.3%        | 
|TERMINAL (d)       |     32/44 (73%)  27/44 (61%)  23/44 (52%)  27/45 (60%) |27/40 (68%)  23/42 (55%)  25/41 (61%)  18/31 (58%)  | 
|FIRST INCIDENCE    |     463          449          722          606         |708          522          478          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045N*    P=0.301N     P=0.010N*    P=0.070N    |P=0.484      P=0.332N     P=0.368N     P=0.562      | 
|POLY 3             |     P=0.047N*    P=0.227N     P=0.007N**   P=0.068N    |P=0.226N     P=0.333N     P=0.375N     P=0.227N     | 
|POLY 1.5           |     P=0.045N*    P=0.238N     P=0.006N**   P=0.068N    |P=0.202N     P=0.371N     P=0.400N     P=0.212N     | 
|POLY 6             |     P=0.052N     P=0.215N     P=0.009N**   P=0.071N    |P=0.255N     P=0.291N     P=0.351N     P=0.245N     | 
|LOGISTIC REGRESSION|     P=0.046N*    P=0.238N     P=0.006N**   P=0.067N    |P=0.251N     P=0.408N     P=0.394N     P=0.317N     | 
|COCH-ARM / FISHERS |     P=0.045N*    P=0.257N     P=0.007N**   P=0.069N    |P=0.160N     P=0.420N     P=0.420N     P=0.184N     | 
|ORDER RESTRICTED   |     P=0.021N*    (e)          (e)          (e)         |P=0.276N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   3/50 (6%)    3/50 (6%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/48.66      5/47.72      3/49.11      3/48.51     |2/46.94      1/46.76      1/47.40      0/43.42      | 
|POLY-3 PERCENT (g) |     6.2%         10.5%        6.1%         6.2%        |4.3%         2.1%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/44 (5%)    4/44 (9%)    1/44 (2%)    3/45 (7%)   |1/40 (3%)    1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     463          585          589          730 (T)     |606          729 (T)      478          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.451N     P=0.358      P=0.656N     P=0.653N    |P=0.176N     P=0.494N     P=0.497N     P=0.275N     | 
|POLY 3             |     P=0.461N     P=0.346      P=0.658N     P=0.660     |P=0.163N     P=0.501N     P=0.497N     P=0.255N     | 
|POLY 1.5           |     P=0.462N     P=0.350      P=0.659N     P=0.661     |P=0.160N     P=0.501N     P=0.499N     P=0.248N     | 
|POLY 6             |     P=0.462N     P=0.344      P=0.655N     P=0.660     |P=0.168N     P=0.502N     P=0.495N     P=0.264N     | 
|LOGISTIC REGRESSION|     P=0.553N     P=0.384      P=0.547      P=0.602     |P=0.121N     P=0.499N     P=0.440N     P=0.213N     | 
|COCH-ARM / FISHERS |     P=0.463N     P=0.357      P=0.661N     P=0.661N    |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.536N     (e)          (e)          (e)         |P=0.133N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum: Peyer's Patch                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      1/48.41      0/48.51     |0/46.52      3/46.76      0/46.69      1/43.72      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         0.0%        |0.0%         6.4%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    1/44 (2%)    0/45 (0%)   |0/40 (0%)    3/42 (7%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      ---         |---          729 (T)      ---          645          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.696      (e)          P=0.500      (e)         |P=0.578      P=0.130      (e)          P=0.491      | 
|POLY 3             |     P=0.700      (e)          P=0.502      (e)         |P=0.613      P=0.120      (e)          P=0.488      | 
|POLY 1.5           |     P=0.698      (e)          P=0.501      (e)         |P=0.621      P=0.119      (e)          P=0.492      | 
|POLY 6             |     P=0.702      (e)          P=0.502      (e)         |P=0.604      P=0.120      (e)          P=0.482      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      (e)         |P=0.627      P=0.130      (e)          P=0.534      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.633N     P=0.121      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.274      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.92      1/47.23      0/48.41      0/48.51     |3/46.93      1/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         0.0%        |6.4%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/44 (2%)    1/44 (2%)    0/44 (0%)    0/45 (0%)   |2/40 (5%)    1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |610          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.233N     P=0.762      P=0.500N     P=0.496N    |P=0.053N     P=0.294N     P=0.119N     P=0.157N     | 
|POLY 3             |     P=0.235N     P=0.757      P=0.498N     P=0.498N    |P=0.044N*    P=0.307N     P=0.120N     P=0.133N     | 
|POLY 1.5           |     P=0.236N     P=0.758      P=0.499N     P=0.498N    |P=0.044N*    P=0.307N     P=0.120N     P=0.128N     | 
|POLY 6             |     P=0.235N     P=0.756      P=0.498N     P=0.497N    |P=0.044N*    P=0.307N     P=0.120N     P=0.141N     | 
|LOGISTIC REGRESSION|     P=0.233N     P=0.762      (e)          (e)         |P=0.043N*    P=0.305N     P=0.118N     P=0.114N     | 
|COCH-ARM / FISHERS |     P=0.235N     P=0.753N     P=0.500N     P=0.500N    |P=0.044N*    P=0.309N     P=0.121N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.246N     (e)          (e)          (e)         |P=0.026N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |2/46.60      0/46.76      0/46.69      1/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |1/40 (3%)    0/42 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |709          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.523N     P=0.234N     P=0.240N     P=0.582N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.458N     P=0.236N     P=0.237N     P=0.525N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.460N     P=0.237N     P=0.238N     P=0.515N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.456N     P=0.236N     P=0.236N     P=0.537N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.488N     P=0.236N     P=0.237N     P=0.542N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.247N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.145N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |4/50 (8%)    1/50 (2%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/48.02      1/47.23      1/48.41      4/48.51     |4/46.52      1/46.76      3/46.69      3/43.72      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         2.1%         8.3%        |8.6%         2.1%         6.4%         6.9%         | 
|TERMINAL (d)       |     0/44 (0%)    1/44 (2%)    1/44 (2%)    4/45 (9%)   |4/40 (10%)   1/42 (2%)    3/41 (7%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     703          730 (T)      730 (T)      730 (T)     |729 (T)      729 (T)      729 (T)      645          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.072      P=0.758      P=0.760      P=0.188     |P=0.485      P=0.165N     P=0.486N     P=0.621N     | 
|POLY 3             |     P=0.069      P=0.757      P=0.759N     P=0.182     |P=0.572      P=0.177N     P=0.498N     P=0.534N     | 
|POLY 1.5           |     P=0.069      P=0.758      P=0.759N     P=0.182     |P=0.578N     P=0.179N     P=0.501N     P=0.521N     | 
|POLY 6             |     P=0.070      P=0.755      P=0.759N     P=0.182     |P=0.559      P=0.176N     P=0.495N     P=0.549N     | 
|LOGISTIC REGRESSION|     P=0.071      P=0.762      P=0.761      P=0.183     |P=0.556      P=0.165N     P=0.486N     P=0.546N     | 
|COCH-ARM / FISHERS |     P=0.067      P=0.753N     P=0.753N     P=0.181     |P=0.563N     P=0.181N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.079      (e)          (e)          (e)         |P=0.390N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     44/50 (88%)  44/50 (88%)  45/50 (90%)  45/50 (90%) |41/50 (82%)  45/50 (90%)  43/50 (86%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     44/49.81     44/50.00     45/49.82     45/49.22    |41/47.85     45/48.79     43/49.50     39/47.39     | 
|POLY-3 PERCENT (g) |     88.4%        88.0%        90.3%        91.4%       |85.7%        92.2%        86.9%        82.3%        | 
|TERMINAL (d)       |     39/44 (89%)  38/44 (86%)  40/44 (91%)  43/45 (96%) |37/40 (93%)  40/42 (95%)  37/41 (90%)  27/31 (87%)  | 
|FIRST INCIDENCE    |     463          449          585          606         |456          522          204          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.535      P=0.580      P=0.505      P=0.603     |P=0.072      P=0.382      P=0.492      P=0.102      | 
|POLY 3             |     P=0.328      P=0.601N     P=0.502      P=0.429     |P=0.232N     P=0.230      P=0.551      P=0.429N     | 
|POLY 1.5           |     P=0.363      P=0.610N     P=0.501      P=0.460     |P=0.225N     P=0.200      P=0.488      P=0.421N     | 
|POLY 6             |     P=0.282      P=0.585N     P=0.503      P=0.386     |P=0.242N     P=0.283      P=0.619      P=0.435N     | 
|LOGISTIC REGRESSION|     P=0.417      P=0.607N     P=0.496      P=0.536     |P=0.315N     P=0.182      P=0.375      P=0.549N     | 
|COCH-ARM / FISHERS |     P=0.409      P=0.620N     P=0.500      P=0.500     |P=0.217N     P=0.194      P=0.393      P=0.402N     | 
|ORDER RESTRICTED   |     P=0.468      (e)          (e)          (e)         |P=0.252N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      1/47.23      2/48.63      0/48.51     |1/46.94      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         4.1%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    1/44 (2%)    1/44 (2%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      671          ---         |608          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.610N     P=0.500      P=0.242      (e)         |P=0.312N     P=0.504N     P=0.500N     P=0.513N     | 
|POLY 3             |     P=0.610N     P=0.497      P=0.241      (e)         |P=0.297N     P=0.501N     P=0.501N     P=0.516N     | 
|POLY 1.5           |     P=0.612N     P=0.498      P=0.240      (e)         |P=0.301N     P=0.501N     P=0.501N     P=0.509N     | 
|POLY 6             |     P=0.609N     P=0.496      P=0.242      (e)         |P=0.292N     P=0.501N     P=0.501N     P=0.523N     | 
|LOGISTIC REGRESSION|     P=0.625N     P=0.500      P=0.218      (e)         |P=0.273N     P=0.479N     P=0.463N     P=0.441N     | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.500      P=0.247      (e)         |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.323N     (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    1/50 (2%)    8/50 (16%)  |1/50 (2%)    2/50 (4%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/47.92      2/47.23      1/48.88      8/48.51     |1/46.52      2/46.76      4/46.69      2/43.65      | 
|POLY-3 PERCENT (g) |     8.4%         4.2%         2.1%         16.5%       |2.2%         4.3%         8.6%         4.6%         | 
|TERMINAL (d)       |     4/44 (9%)    2/44 (5%)    0/44 (0%)    8/45 (18%)  |1/40 (3%)    2/42 (5%)    4/41 (10%)   0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      589          730 (T)     |729 (T)      729 (T)      729 (T)      675          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061      P=0.337N     P=0.181N     P=0.188     |P=0.279      P=0.517      P=0.187      P=0.428      | 
|POLY 3             |     P=0.057      P=0.344N     P=0.173N     P=0.184     |P=0.345      P=0.502      P=0.180      P=0.478      | 
|POLY 1.5           |     P=0.056      P=0.342N     P=0.175N     P=0.182     |P=0.361      P=0.501      P=0.179      P=0.486      | 
|POLY 6             |     P=0.057      P=0.347N     P=0.171N     P=0.185     |P=0.327      P=0.503      P=0.182      P=0.468      | 
|LOGISTIC REGRESSION|     P=0.058      P=0.337N     P=0.196N     P=0.188     |P=0.337      P=0.517      P=0.187      P=0.483      | 
|COCH-ARM / FISHERS |     P=0.056      P=0.339N     P=0.181N     P=0.178     |P=0.387      P=0.500      P=0.181      P=0.500      | 
|ORDER RESTRICTED   |     P=0.021 *    (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     49/50 (98%)  50/50 (100%) 50/50 (100%) 50/50 (100%)|15/50 (30%)  31/50 (62%)  36/50 (72%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     49/50.00     50/50.00     50/50.00     50/50.00    |15/47.35     31/47.99     36/47.81     49/49.17     | 
|POLY-3 PERCENT (g) |     98.0%        100.0%       100.0%       100.0%      |31.7%        64.6%        75.3%        99.7%        | 
|TERMINAL (d)       |     43/44 (98%)  44/44 (100%) 44/44 (100%) 45/45 (100%)|13/40 (33%)  26/42 (62%)  31/41 (76%)  31/31 (100%) | 
|FIRST INCIDENCE    |     463          449          585          568         |606          561          555          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.510N     P=0.488      P=0.506      P=0.604N    |P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.306      P=0.500      P=0.500      P=0.500     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.306      P=0.500      P=0.500      P=0.500     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.306      P=0.500      P=0.500      P=0.500     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.306      P=0.500      P=0.500      P=0.500     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.121      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     49/50 (98%)  48/50 (96%)  50/50 (100%) 50/50 (100%)|21/50 (42%)  33/50 (66%)  31/50 (62%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     49/49.41     48/49.05     50/50.00     50/50.00    |21/47.02     33/47.18     31/48.48     30/45.22     | 
|POLY-3 PERCENT (g) |     99.2%        97.9%        100.0%       100.0%      |44.7%        70.0%        63.9%        66.3%        | 
|TERMINAL (d)       |     44/44 (100%) 44/44 (100%) 44/44 (100%) 45/45 (100%)|19/40 (48%)  31/42 (74%)  28/41 (68%)  23/31 (74%)  | 
|FIRST INCIDENCE    |     463          449          585          568         |606          641          204          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.517      P=0.513N     P=0.505      P=0.614N    |P=0.003 **   P=0.022 *    P=0.046 *    P=0.003 **   | 
|POLY 3             |     P=0.346      P=0.658N     P=0.927      P=0.927     |P=0.055      P=0.009 **   P=0.042 *    P=0.026 *    | 
|POLY 1.5           |     P=0.249      P=0.562N     P=0.714      P=0.714     |P=0.073      P=0.010 *    P=0.040 *    P=0.034 *    | 
|POLY 6             |     P=0.667      P=0.903N     P=1.000      P=1.000     |P=0.038 *    P=0.009 **   P=0.043 *    P=0.017 *    | 
|LOGISTIC REGRESSION|     P=0.371      P=0.562N     P=0.814      P=0.801     |P=0.056      P=0.012 *    P=0.035 *    P=0.023 *    | 
|COCH-ARM / FISHERS |     P=0.188      P=0.500N     P=0.500      P=0.500     |P=0.109      P=0.013 *    P=0.036 *    P=0.055      | 
|ORDER RESTRICTED   |     P=0.173      (e)          (e)          (e)         |P=0.017 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/50 (16%)   12/50 (24%)  22/50 (44%) |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.92      8/47.23      12/48.88     22/48.51    |0/46.52      1/47.68      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     8.4%         16.9%        24.6%        45.4%       |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/44 (9%)    8/44 (18%)   11/44 (25%)  22/45 (49%) |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      589          730 (T)     |---          316          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.177      P=0.029 *    P<0.001 **  |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.170      P=0.029 *    P<0.001 **  |P=0.566N     P=0.505      (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.174      P=0.028 *    P<0.001 **  |P=0.567N     P=0.503      (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.167      P=0.029 *    P<0.001 **  |P=0.565N     P=0.506      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.177      P=0.029 *    P<0.001 **  |P=0.464N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.178      P=0.027 *    P<0.001 **  |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.397N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |2/46.52      0/46.76      1/46.69      4/43.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         2.1%         9.1%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |2/40 (5%)    0/42 (0%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          729 (T)      606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.067      P=0.228N     P=0.491N     P=0.248      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.099      P=0.236N     P=0.499N     P=0.311      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.102      P=0.237N     P=0.501N     P=0.321      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.096      P=0.235N     P=0.497N     P=0.300      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.101      (e)          P=0.491N     P=0.321      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.108      P=0.247N     P=0.500N     P=0.339      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.062      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    5/50 (10%)   0/50 (0%)   |3/50 (6%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/48.07      2/47.23      5/48.59      0/48.51     |3/46.93      0/46.76      1/46.69      2/43.71      | 
|POLY-3 PERCENT (g) |     8.3%         4.2%         10.3%        0.0%        |6.4%         0.0%         2.1%         4.6%         | 
|TERMINAL (d)       |     3/44 (7%)    2/44 (5%)    4/44 (9%)    0/45 (0%)   |2/40 (5%)    0/42 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     690          730 (T)      683          ---         |610          ---          729 (T)      677          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.340N     P=0.498      P=0.062N    |P=0.598      P=0.117N     P=0.298N     P=0.580N     | 
|POLY 3             |     P=0.089N     P=0.346N     P=0.507      P=0.059N    |P=0.565N     P=0.119N     P=0.307N     P=0.532N     | 
|POLY 1.5           |     P=0.091N     P=0.342N     P=0.505      P=0.060N    |P=0.562N     P=0.120N     P=0.308N     P=0.520N     | 
|POLY 6             |     P=0.088N     P=0.350N     P=0.507      P=0.059N    |P=0.569N     P=0.120N     P=0.307N     P=0.547N     | 
|LOGISTIC REGRESSION|     P=0.092N     P=0.344N     P=0.502      P=0.062N    |P=0.551N     P=0.120N     P=0.304N     P=0.491N     | 
|COCH-ARM / FISHERS |     P=0.095N     P=0.339N     P=0.500      P=0.059N    |P=0.556N     P=0.121N     P=0.309N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.054N     (e)          (e)          (e)         |P=0.207N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   7/50 (14%)   12/50 (24%) |3/50 (6%)    2/50 (4%)    4/50 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/47.92      7/47.23      7/48.41      12/48.51    |3/46.52      2/46.76      4/46.69      4/43.84      | 
|POLY-3 PERCENT (g) |     4.2%         14.8%        14.5%        24.7%       |6.5%         4.3%         8.6%         9.1%         | 
|TERMINAL (d)       |     2/44 (5%)    7/44 (16%)   7/44 (16%)   12/45 (27%) |3/40 (8%)    2/42 (5%)    4/41 (10%)   3/31 (10%)   | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      730 (T)      730 (T)     |729 (T)      729 (T)      729 (T)      606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   P=0.081      P=0.081      P=0.005 **  |P=0.210      P=0.478N     P=0.514      P=0.378      | 
|POLY 3             |     P=0.004 **   P=0.076      P=0.082      P=0.004 **  |P=0.299      P=0.498N     P=0.502      P=0.468      | 
|POLY 1.5           |     P=0.004 **   P=0.077      P=0.081      P=0.004 **  |P=0.311      P=0.499N     P=0.499      P=0.480      | 
|POLY 6             |     P=0.004 **   P=0.074      P=0.082      P=0.004 **  |P=0.284      P=0.496N     P=0.505      P=0.453      | 
|LOGISTIC REGRESSION|     P=0.005 **   P=0.081      P=0.081      P=0.005 **  |P=0.286      P=0.478N     P=0.514      P=0.468      | 
|COCH-ARM / FISHERS |     P=0.004 **   P=0.080      P=0.080      P=0.004 **  |P=0.331      P=0.500N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.002 **   (e)          (e)          (e)         |P=0.391      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   11/50 (22%)  10/50 (20%) |2/50 (4%)    2/50 (4%)    7/50 (14%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     5/48.20      8/47.23      11/48.41     10/48.51    |2/46.52      2/46.76      7/46.69      7/43.49      | 
|POLY-3 PERCENT (g) |     10.4%        16.9%        22.7%        20.6%       |4.3%         4.3%         15.0%        16.1%        | 
|TERMINAL (d)       |     4/44 (9%)    8/44 (18%)   11/44 (25%)  10/45 (22%) |2/40 (5%)    2/42 (5%)    7/41 (17%)   6/31 (19%)   | 
|FIRST INCIDENCE    |     652          730 (T)      730 (T)      730 (T)     |729 (T)      729 (T)      729 (T)      711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124      P=0.274      P=0.087      P=0.143     |P=0.007 **   P=0.677N     P=0.086      P=0.037 *    | 
|POLY 3             |     P=0.119      P=0.263      P=0.086      P=0.133     |P=0.018 *    P=0.692N     P=0.080      P=0.063      | 
|POLY 1.5           |     P=0.118      P=0.269      P=0.086      P=0.133     |P=0.021 *    P=0.693N     P=0.079      P=0.069      | 
|POLY 6             |     P=0.119      P=0.256      P=0.084      P=0.132     |P=0.016 *    P=0.690N     P=0.081      P=0.057      | 
|LOGISTIC REGRESSION|     P=0.124      P=0.265      P=0.089      P=0.137     |P=0.009 **   P=0.677N     P=0.086      P=0.042 *    | 
|COCH-ARM / FISHERS |     P=0.113      P=0.277      P=0.086      P=0.131     |P=0.027 *    P=0.691N     P=0.080      P=0.080      | 
|ORDER RESTRICTED   |     P=0.109      (e)          (e)          (e)         |P=0.042 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |18/50 (36%)  11/50 (22%)  20/50 (40%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     2/48.66      1/47.23      0/48.41      0/48.51     |18/47.60     11/46.76     20/47.77     19/45.99     | 
|POLY-3 PERCENT (g) |     4.1%         2.1%         0.0%         0.0%        |37.8%        23.5%        41.9%        41.3%        | 
|TERMINAL (d)       |     1/44 (2%)    1/44 (2%)    0/44 (0%)    0/45 (0%)   |13/40 (33%)  11/42 (26%)  16/41 (39%)  11/31 (36%)  | 
|FIRST INCIDENCE    |     463          730 (T)      ---          ---         |606          729 (T)      555          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101N     P=0.502N     P=0.240N     P=0.237N    |P=0.067      P=0.082N     P=0.448      P=0.236      | 
|POLY 3             |     P=0.100N     P=0.510N     P=0.239N     P=0.238N    |P=0.203      P=0.099N     P=0.423      P=0.447      | 
|POLY 1.5           |     P=0.100N     P=0.507N     P=0.238N     P=0.238N    |P=0.217      P=0.096N     P=0.416      P=0.469      | 
|POLY 6             |     P=0.099N     P=0.514N     P=0.239N     P=0.238N    |P=0.186      P=0.105N     P=0.429      P=0.415      | 
|LOGISTIC REGRESSION|     P=0.138N     P=0.465N     P=0.388N     P=0.383N    |P=0.210      P=0.089N     P=0.416      P=0.492      | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.240      P=0.093N     P=0.418      P=0.500      | 
|ORDER RESTRICTED   |     P=0.075N     (e)          (e)          (e)         |P=0.213      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.92      2/47.23      0/48.41      1/48.51     |0/46.52      0/46.76      0/46.69      1/43.70      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         2.1%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/44 (0%)    2/44 (5%)    0/44 (0%)    1/45 (2%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      ---          730 (T)     |---          ---          ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.545      P=0.238      (e)          P=0.504     |P=0.187      (e)          (e)          P=0.486      | 
|POLY 3             |     P=0.543      P=0.234      (e)          P=0.502     |P=0.190      (e)          (e)          P=0.488      | 
|POLY 1.5           |     P=0.542      P=0.235      (e)          P=0.502     |P=0.194      (e)          (e)          P=0.492      | 
|POLY 6             |     P=0.544      P=0.233      (e)          P=0.503     |P=0.187      (e)          (e)          P=0.482      | 
|LOGISTIC REGRESSION|     (e)          P=0.238      (e)          P=0.504     |P=0.214      (e)          (e)          P=0.530      | 
|COCH-ARM / FISHERS |     P=0.539      P=0.247      (e)          P=0.500     |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.324      (e)          (e)          (e)         |P=0.109      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   10/50 (20%)  0/50 (0%)    4/50 (8%)   |36/50 (72%)  38/50 (76%)  35/50 (70%)  35/50 (70%)  | 
|POLY-3 RATE (b)    |     6/47.92      10/47.72     0/48.41      4/48.51     |36/46.68     38/47.16     35/48.18     35/47.13     | 
|POLY-3 PERCENT (g) |     12.5%        21.0%        0.0%         8.3%        |77.1%        80.6%        72.7%        74.3%        | 
|TERMINAL (d)       |     6/44 (14%)   9/44 (21%)   0/44 (0%)    4/45 (9%)   |34/40 (85%)  36/42 (86%)  31/41 (76%)  24/31 (77%)  | 
|FIRST INCIDENCE    |     730 (T)      585          ---          730 (T)     |708          641          478          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095N     P=0.208      P=0.018N*    P=0.355N    |P=0.070      P=0.575      P=0.430N     P=0.103      | 
|POLY 3             |     P=0.092N     P=0.203      P=0.015N*    P=0.362N    |P=0.326N     P=0.435      P=0.393N     P=0.466N     | 
|POLY 1.5           |     P=0.094N     P=0.205      P=0.015N*    P=0.365N    |P=0.349N     P=0.417      P=0.448N     P=0.485N     | 
|POLY 6             |     P=0.091N     P=0.203      P=0.015N*    P=0.361N    |P=0.303N     P=0.462      P=0.333N     P=0.446N     | 
|LOGISTIC REGRESSION|     P=0.096N     P=0.199      (e)          P=0.355N    |P=0.520      P=0.448      P=0.476N     P=0.516      | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.207      P=0.013N*    P=0.370N    |P=0.375N     P=0.410      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.025N*    (e)          (e)          (e)         |P=0.418N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  47/50 (94%)  44/50 (88%)  42/50 (84%) |44/50 (88%)  40/50 (80%)  41/50 (82%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     33/48.97     47/50.00     44/49.78     42/49.18    |44/48.02     40/47.70     41/49.80     36/46.70     | 
|POLY-3 PERCENT (g) |     67.4%        94.0%        88.4%        85.4%       |91.6%        83.9%        82.3%        77.1%        | 
|TERMINAL (d)       |     29/44 (66%)  41/44 (93%)  39/44 (89%)  40/45 (89%) |38/40 (95%)  37/42 (88%)  34/41 (83%)  28/31 (90%)  | 
|FIRST INCIDENCE    |     540          449          585          568         |606          561          204          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.162      P=0.004 **   P=0.022 *    P=0.062     |P=0.343      P=0.110N     P=0.264N     P=0.490      | 
|POLY 3             |     P=0.059      P<0.001 **   P=0.009 **   P=0.028 *   |P=0.038N*    P=0.186N     P=0.138N     P=0.036N*    | 
|POLY 1.5           |     P=0.064      P<0.001 **   P=0.009 **   P=0.029 *   |P=0.035N*    P=0.191N     P=0.182N     P=0.034N*    | 
|POLY 6             |     P=0.049 *    P<0.001 **   P=0.010 *    P=0.024 *   |P=0.049N*    P=0.193N     P=0.108N     P=0.047N*    | 
|LOGISTIC REGRESSION|     P=0.080      P<0.001 **   P=0.010 *    P=0.038 *   |P=0.072N     P=0.157N     P=0.299N     P=0.080N     | 
|COCH-ARM / FISHERS |     P=0.072      P<0.001 **   P=0.008 **   P=0.032 *   |P=0.038N*    P=0.207N     P=0.288N     P=0.039N*    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.032N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   9/50 (18%)   15/50 (30%)  13/50 (26%) |2/50 (4%)    5/50 (10%)   3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     8/48.20      9/47.72      15/48.41     13/48.79    |2/46.52      5/46.76      3/46.69      2/43.42      | 
|POLY-3 PERCENT (g) |     16.6%        18.9%        31.0%        26.7%       |4.3%         10.7%        6.4%         4.6%         | 
|TERMINAL (d)       |     7/44 (16%)   8/44 (18%)   15/44 (34%)  12/45 (27%) |2/40 (5%)    5/42 (12%)   3/41 (7%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     652          585          730 (T)      656         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113      P=0.497      P=0.077      P=0.181     |P=0.557N     P=0.236      P=0.511      P=0.600      | 
|POLY 3             |     P=0.107      P=0.491      P=0.076      P=0.170     |P=0.459N     P=0.218      P=0.502      P=0.669      | 
|POLY 1.5           |     P=0.104      P=0.495      P=0.077      P=0.168     |P=0.445N     P=0.217      P=0.499      P=0.678      | 
|POLY 6             |     P=0.108      P=0.487      P=0.074      P=0.171     |P=0.477N     P=0.220      P=0.504      P=0.657      | 
|LOGISTIC REGRESSION|     P=0.108      P=0.497      P=0.080      P=0.169     |P=0.557N     P=0.236      P=0.511      P=0.600      | 
|COCH-ARM / FISHERS |     P=0.099      P=0.500      P=0.077      P=0.163     |P=0.420N     P=0.218      P=0.500      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.116      (e)          (e)          (e)         |P=0.450      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |4/50 (8%)    8/50 (16%)   3/50 (6%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/47.92      1/47.23      0/48.41      1/48.65     |4/46.52      8/46.76      3/46.69      7/44.58      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         0.0%         2.1%        |8.6%         17.1%        6.4%         15.7%        | 
|TERMINAL (d)       |     1/44 (2%)    1/44 (2%)    0/44 (0%)    0/45 (0%)   |4/40 (10%)   8/42 (19%)   3/41 (7%)    5/31 (16%)   | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          695         |729 (T)      729 (T)      729 (T)      466          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.607N     P=0.762      P=0.500N     P=0.753N    |P=0.196      P=0.200      P=0.486N     P=0.155      | 
|POLY 3             |     P=0.613N     P=0.757      P=0.498N     P=0.757N    |P=0.323      P=0.179      P=0.498N     P=0.237      | 
|POLY 1.5           |     P=0.614N     P=0.758      P=0.499N     P=0.758N    |P=0.333      P=0.178      P=0.501N     P=0.246      | 
|POLY 6             |     P=0.612N     P=0.756      P=0.498N     P=0.756N    |P=0.311      P=0.181      P=0.495N     P=0.224      | 
|LOGISTIC REGRESSION|     P=0.616N     P=0.762      (e)          P=0.759     |P=0.321      P=0.200      P=0.486N     P=0.263      | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.753N     P=0.500N     P=0.753N    |P=0.351      P=0.178      P=0.500N     P=0.262      | 
|ORDER RESTRICTED   |     P=0.528N     (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      3/47.23      0/48.41      1/48.51     |0/46.52      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         6.4%         0.0%         2.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    3/44 (7%)    0/44 (0%)    1/45 (2%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      ---          730 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.626N     P=0.121      (e)          P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.632N     P=0.116      (e)          P=0.502     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.632N     P=0.117      (e)          P=0.502     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.632N     P=0.115      (e)          P=0.503     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.121      (e)          P=0.504     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.633N     P=0.121      (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.267      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    5/50 (10%)   30/50 (60%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      5/48.41      30/49.04    |0/46.52      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         10.3%        61.2%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    5/44 (11%)   29/45 (64%) |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      568         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.034 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P=0.032 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.031 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P=0.032 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.034 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.028 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    41/50 (82%)  47/50 (94%)  48/50 (96%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      41/48.85     47/50.00     48/49.88    |0/46.52      0/46.76      0/46.69      2/43.62      | 
|POLY-3 PERCENT (g) |     0.0%         83.9%        94.0%        96.2%       |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    37/44 (84%)  41/44 (93%)  44/45 (98%) |0/40 (0%)    0/42 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          554          585          568         |---          ---          ---          677          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.032 *    (e)          (e)          P=0.197      | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.043 *    (e)          (e)          P=0.223      | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.044 *    (e)          (e)          P=0.228      | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.042 *    (e)          (e)          P=0.217      | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.045 *    (e)          (e)          P=0.230      | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.025 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   8/50 (16%)   8/50 (16%)  |3/50 (6%)    5/50 (10%)   4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.92      6/48.24      8/49.27      8/49.20     |3/47.36      5/48.32      4/47.71      0/43.42      | 
|POLY-3 PERCENT (g) |     2.1%         12.4%        16.2%        16.3%       |6.3%         10.4%        8.4%         0.0%         | 
|TERMINAL (d)       |     1/44 (2%)    3/44 (7%)    5/44 (11%)   5/45 (11%)  |0/40 (0%)    2/42 (5%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      585          585          606         |606          316          204          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    P=0.062      P=0.021 *    P=0.023 *   |P=0.114N     P=0.366      P=0.504      P=0.149N     | 
|POLY 3             |     P=0.031 *    P=0.057      P=0.018 *    P=0.018 *   |P=0.103N     P=0.368      P=0.504      P=0.135N     | 
|POLY 1.5           |     P=0.030 *    P=0.057      P=0.017 *    P=0.017 *   |P=0.093N     P=0.365      P=0.504      P=0.129N     | 
|POLY 6             |     P=0.033 *    P=0.059      P=0.019 *    P=0.019 *   |P=0.116N     P=0.370      P=0.502      P=0.144N     | 
|LOGISTIC REGRESSION|     P=0.017 *    P=0.063      P=0.013 *    P=0.015 *   |P=0.036N*    P=0.350      P=0.550      P=0.089N     | 
|COCH-ARM / FISHERS |     P=0.028 *    P=0.056      P=0.015 *    P=0.015 *   |P=0.079N     P=0.357      P=0.500      P=0.121N     | 
|ORDER RESTRICTED   |     P=0.020 *    (e)          (e)          (e)         |P=0.082N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     44/50 (88%)  45/50 (90%)  46/50 (92%)  44/50 (88%) |41/50 (82%)  43/50 (86%)  39/50 (78%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     44/48.47     45/48.28     46/48.92     44/49.22    |41/47.52     43/49.10     39/47.69     34/44.89     | 
|POLY-3 PERCENT (g) |     90.8%        93.2%        94.0%        89.4%       |86.3%        87.6%        81.8%        75.7%        | 
|TERMINAL (d)       |     41/44 (93%)  42/44 (96%)  44/44 (100%) 42/45 (93%) |37/40 (93%)  38/42 (91%)  36/41 (88%)  29/31 (94%)  | 
|FIRST INCIDENCE    |     652          585          589          606         |606          316          555          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.402N     P=0.492      P=0.363      P=0.504N    |P=0.413      P=0.582      P=0.309N     P=0.402      | 
|POLY 3             |     P=0.421N     P=0.473      P=0.404      P=0.545N    |P=0.065N     P=0.547      P=0.370N     P=0.133N     | 
|POLY 1.5           |     P=0.467N     P=0.485      P=0.400      P=0.572N    |P=0.043N*    P=0.488      P=0.396N     P=0.104N     | 
|POLY 6             |     P=0.391N     P=0.459      P=0.370      P=0.531N    |P=0.115N     P=0.601      P=0.345N     P=0.197N     | 
|LOGISTIC REGRESSION|     P=0.377N     P=0.346      P=0.393      P=0.555N    |P=0.070N     P=0.393      P=0.356N     P=0.193N     | 
|COCH-ARM / FISHERS |     P=0.547N     P=0.500      P=0.370      P=0.620N    |P=0.026N*    P=0.393      P=0.402N     P=0.083N     | 
|ORDER RESTRICTED   |     P=0.415N     (e)          (e)          (e)         |P=0.102N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    44/50 (88%)  50/50 (100%) 48/50 (96%) |0/50 (0%)    29/50 (58%)  44/50 (88%)  37/50 (74%)  | 
|POLY-3 RATE (b)    |     0/47.92      44/48.43     50/50.00     48/49.88    |0/46.52      29/48.08     44/49.35     37/47.04     | 
|POLY-3 PERCENT (g) |     0.0%         90.9%        100.0%       96.2%       |0.0%         60.3%        89.2%        78.7%        | 
|TERMINAL (d)       |     0/44 (0%)    42/44 (96%)  44/44 (100%) 44/45 (98%) |0/40 (0%)    26/42 (62%)  39/41 (95%)  26/31 (84%)  | 
|FIRST INCIDENCE    |     ---          449          585          568         |---          561          204          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  38/50 (76%)  47/50 (94%)  36/50 (72%) |33/50 (66%)  44/50 (88%)  44/50 (88%)  35/50 (70%)  | 
|POLY-3 RATE (b)    |     32/49.41     38/48.71     47/49.81     36/48.51    |33/47.70     44/48.79     44/49.80     35/47.57     | 
|POLY-3 PERCENT (g) |     64.8%        78.0%        94.4%        74.2%       |69.2%        90.2%        88.4%        73.6%        | 
|TERMINAL (d)       |     27/44 (61%)  35/44 (80%)  42/44 (96%)  36/45 (80%) |31/40 (78%)  39/42 (93%)  37/41 (90%)  26/31 (84%)  | 
|FIRST INCIDENCE    |     463          554          585          730 (T)     |456          522          204          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292      P=0.162      P=0.003 **   P=0.319     |P=0.029 *    P=0.023 *    P=0.021 *    P=0.034 *    | 
|POLY 3             |     P=0.150      P=0.107      P<0.001 **   P=0.212     |P=0.522N     P=0.007 **   P=0.015 *    P=0.400      | 
|POLY 1.5           |     P=0.174      P=0.118      P<0.001 **   P=0.234     |P=0.505N     P=0.006 **   P=0.011 *    P=0.409      | 
|POLY 6             |     P=0.116      P=0.097      P<0.001 **   P=0.178     |P=0.541      P=0.009 **   P=0.022 *    P=0.378      | 
|LOGISTIC REGRESSION|     P=0.243      P=0.130      P<0.001 **   P=0.285     |P=0.526      P=0.007 **   P=0.008 **   P=0.357      | 
|COCH-ARM / FISHERS |     P=0.207      P=0.138      P<0.001 **   P=0.260     |P=0.500N     P=0.008 **   P=0.008 **   P=0.415      | 
|ORDER RESTRICTED   |     P=0.010 *    (e)          (e)          (e)         |P=0.037 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.92      2/47.23      1/48.59      1/48.51     |0/46.52      1/46.76      1/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     2.1%         4.2%         2.1%         2.1%        |0.0%         2.1%         2.1%         0.0%         | 
|TERMINAL (d)       |     1/44 (2%)    2/44 (5%)    0/44 (0%)    1/45 (2%)   |0/40 (0%)    1/42 (2%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      683          730 (T)     |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.522N     P=0.500      P=0.760      P=0.757N    |P=0.653N     P=0.510      P=0.505      (e)          | 
|POLY 3             |     P=0.525N     P=0.495      P=0.757N     P=0.758N    |P=0.612N     P=0.501      P=0.501      (e)          | 
|POLY 1.5           |     P=0.527N     P=0.497      P=0.758N     P=0.758N    |P=0.605N     P=0.500      P=0.500      (e)          | 
|POLY 6             |     P=0.524N     P=0.493      P=0.757N     P=0.757N    |P=0.620N     P=0.502      P=0.502      (e)          | 
|LOGISTIC REGRESSION|     P=0.527N     P=0.500      P=0.755      P=0.757N    |(e)          P=0.510      P=0.505      (e)          | 
|COCH-ARM / FISHERS |     P=0.530N     P=0.500      P=0.753N     P=0.753N    |P=0.595N     P=0.500      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.577N     (e)          (e)          (e)         |P=0.405      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      0/46.76      0/46.69      2/43.62      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          677          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.032 *    (e)          (e)          P=0.197      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.223      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.228      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.217      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.230      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.025 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   7/50 (14%)   8/50 (16%)   4/50 (8%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/48.20      7/47.23      8/48.41      4/48.51     |1/46.52      1/46.76      2/46.78      2/43.42      | 
|POLY-3 PERCENT (g) |     12.5%        14.8%        16.5%        8.3%        |2.2%         2.1%         4.3%         4.6%         | 
|TERMINAL (d)       |     5/44 (11%)   7/44 (16%)   8/44 (18%)   4/45 (9%)   |1/40 (3%)    1/42 (2%)    1/41 (2%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     652          730 (T)      730 (T)      730 (T)     |729 (T)      729 (T)      704          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.279N     P=0.496      P=0.387      P=0.358N    |P=0.251      P=0.751N     P=0.503      P=0.411      | 
|POLY 3             |     P=0.285N     P=0.484      P=0.390      P=0.366N    |P=0.309      P=0.759N     P=0.502      P=0.476      | 
|POLY 1.5           |     P=0.288N     P=0.491      P=0.390      P=0.367N    |P=0.320      P=0.760N     P=0.500      P=0.485      | 
|POLY 6             |     P=0.284N     P=0.476      P=0.387      P=0.367N    |P=0.295      P=0.758N     P=0.505      P=0.464      | 
|LOGISTIC REGRESSION|     P=0.278N     P=0.487      P=0.394      P=0.364N    |P=0.288      P=0.751N     P=0.502      P=0.411      | 
|COCH-ARM / FISHERS |     P=0.294N     P=0.500      P=0.387      P=0.370N    |P=0.337      P=0.753N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.281N     (e)          (e)          (e)         |P=0.411      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |2/47.69      0/46.76      0/46.69      3/43.62      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.2%         0.0%         0.0%         6.9%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |456          ---          ---          677          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.203      P=0.242N     P=0.240N     P=0.432      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.236      P=0.242N     P=0.242N     P=0.459      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.239      P=0.240N     P=0.241N     P=0.475      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.233      P=0.243N     P=0.243N     P=0.442      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.294      P=0.175N     P=0.143N     P=0.585      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.245      P=0.247N     P=0.247N     P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.082      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   1/50 (2%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     7/48.11      1/47.23      1/48.41      3/48.51     |1/46.93      0/46.76      0/46.69      2/43.62      | 
|POLY-3 PERCENT (g) |     14.6%        2.1%         2.1%         6.2%        |2.1%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     6/44 (14%)   1/44 (2%)    1/44 (2%)    3/45 (7%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     679          730 (T)      730 (T)      730 (T)     |610          ---          ---          677          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152N     P=0.035N*    P=0.034N*    P=0.153N    |P=0.211      P=0.500N     P=0.496N     P=0.449      | 
|POLY 3             |     P=0.149N     P=0.032N*    P=0.030N*    P=0.155N    |P=0.237      P=0.501N     P=0.501N     P=0.474      | 
|POLY 1.5           |     P=0.151N     P=0.032N*    P=0.030N*    P=0.156N    |P=0.240      P=0.501N     P=0.501N     P=0.484      | 
|POLY 6             |     P=0.147N     P=0.033N*    P=0.030N*    P=0.155N    |P=0.234      P=0.501N     P=0.501N     P=0.462      | 
|LOGISTIC REGRESSION|     P=0.151N     P=0.034N*    P=0.032N*    P=0.153N    |P=0.264      P=0.480N     P=0.464N     P=0.528      | 
|COCH-ARM / FISHERS |     P=0.157N     P=0.030N*    P=0.030N*    P=0.159N    |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.014N*    (e)          (e)          (e)         |P=0.114      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/48 (10%)   1/50 (2%)    6/49 (12%)   5/47 (11%)  |4/50 (8%)    20/50 (40%)  12/50 (24%)  9/49 (18%)   | 
|POLY-3 RATE (b)    |     5/46.27      1/47.23      6/48.31      5/46.45     |4/46.52      20/47.53     12/47.50     9/43.51      | 
|POLY-3 PERCENT (g) |     10.8%        2.1%         12.4%        10.8%       |8.6%         42.1%        25.3%        20.7%        | 
|TERMINAL (d)       |     5/44 (11%)   1/44 (2%)    3/43 (7%)    3/43 (7%)   |4/40 (10%)   18/42 (43%)  10/41 (24%)  7/31 (23%)   | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      585          568         |729 (T)      595          478          466          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347      P=0.104N     P=0.494      P=0.621     |P=0.242      P<0.001 **   P=0.033 *    P=0.054      | 
|POLY 3             |     P=0.352      P=0.097N     P=0.530      P=0.627N    |P=0.398      P<0.001 **   P=0.028 *    P=0.090      | 
|POLY 1.5           |     P=0.343      P=0.095N     P=0.525      P=0.627     |P=0.422      P<0.001 **   P=0.027 *    P=0.097      | 
|POLY 6             |     P=0.362      P=0.099N     P=0.535      P=0.622N    |P=0.366      P<0.001 **   P=0.030 *    P=0.082      | 
|LOGISTIC REGRESSION|     P=0.285      P=0.104N     P=0.491      P=0.593     |P=0.423      P<0.001 **   P=0.028 *    P=0.100      | 
|COCH-ARM / FISHERS |     P=0.328      P=0.093N     P=0.515      P=0.616     |P=0.466      P<0.001 **   P=0.027 *    P=0.109      | 
|ORDER RESTRICTED   |     P=0.306      (e)          (e)          (e)         |P=0.012 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    0/49 (0%)    2/48 (4%)   |6/50 (12%)   12/49 (24%)  6/49 (12%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/46.92      2/47.23      0/47.59      2/46.65     |6/46.52      12/47.13     6/45.94      4/43.84      | 
|POLY-3 PERCENT (g) |     4.3%         4.2%         0.0%         4.3%        |12.9%        25.5%        13.1%        9.1%         | 
|TERMINAL (d)       |     2/43 (5%)    2/44 (5%)    0/44 (0%)    2/44 (5%)   |6/40 (15%)   11/42 (26%)  5/41 (12%)   3/31 (10%)   | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          730 (T)     |729 (T)      595          704          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.549N     P=0.686N     P=0.233N     P=0.686N    |P=0.264N     P=0.115      P=0.606N     P=0.523N     | 
|POLY 3             |     P=0.561N     P=0.691N     P=0.234N     P=0.692     |P=0.164N     P=0.099      P=0.612      P=0.407N     | 
|POLY 1.5           |     P=0.563N     P=0.689N     P=0.235N     P=0.690     |P=0.152N     P=0.095      P=0.606      P=0.393N     | 
|POLY 6             |     P=0.560N     P=0.693N     P=0.233N     P=0.693     |P=0.178N     P=0.103      P=0.619      P=0.425N     | 
|LOGISTIC REGRESSION|     P=0.549N     P=0.686N     (e)          P=0.686N    |P=0.170N     P=0.097      P=0.622      P=0.421N     | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.684N     P=0.247N     P=0.684     |P=0.134N     P=0.088      P=0.606      P=0.370N     | 
|ORDER RESTRICTED   |     P=0.442N     (e)          (e)          (e)         |P=0.142N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/1 (0%)     0/3 (0%)     0/5 (0%)    |1/8 (13%)    1/12 (8%)    0/11 (0%)    2/15 (13%)   | 
|POLY-3 RATE (b)    |     0/0.81       0/1.00       0/2.60       0/4.88      |1/6.27       1/11.16      0/9.83       2/12.29      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |15.9%        9.0%         0.0%         16.3%        | 
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/1 (0%)     0/4 (0%)    |0/3 (0%)     1/9 (11%)    0/7 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |608          729 (T)      ---          466          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.332      P=0.647N     P=0.496N     P=0.467      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.505      P=0.626N     P=0.410N     P=0.733      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.515      P=0.642N     P=0.420N     P=0.728      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.488      P=0.607N     P=0.397N     P=0.733      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.550      P=0.730N     P=0.512N     P=0.700      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.524      P=0.653N     P=0.421N     P=0.743N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.475      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     1/1 (100%)   1/3 (33%)    0/5 (0%)    |2/8 (25%)    5/12 (42%)   4/11 (36%)   4/15 (27%)   | 
|POLY-3 RATE (b)    |     0/0.81       1/1.00       1/2.82       0/4.88      |2/6.35       5/11.16      4/10.65      4/11.98      | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       35.5%        0.0%        |31.5%        44.8%        37.6%        33.4%        | 
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   0/1 (0%)     0/4 (0%)    |0/3 (0%)     5/9 (56%)    2/7 (29%)    2/4 (50%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      671          ---         |608          729 (T)      478          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.314N     P=1.000N     P=0.504      (e)         |P=0.282      P=0.594      P=0.466      P=0.341      | 
|POLY 3             |     P=0.119N     P=1.000N     P=0.715      (e)         |P=0.486N     P=0.485      P=0.600      P=0.667      | 
|POLY 1.5           |     P=0.144N     P=1.000N     P=0.703      (e)         |P=0.466N     P=0.449      P=0.558      P=0.664      | 
|POLY 6             |     P=0.081N     P=1.000N     P=0.737      (e)         |P=0.522N     P=0.523      P=0.644      P=0.660      | 
|LOGISTIC REGRESSION|     P=0.312N     P=1.000N     (e)          (e)         |P=0.474N     P=0.581      P=0.436      P=0.689      | 
|COCH-ARM / FISHERS |     P=0.217N     P=0.500      P=0.750      (e)         |P=0.446N     P=0.392      P=0.494      P=0.712N     | 
|ORDER RESTRICTED   |     P=0.373N     (e)          (e)          (e)         |P=0.621      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/1 (0%)     0/3 (0%)     0/5 (0%)    |0/8 (0%)     0/12 (0%)    2/11 (18%)   1/15 (7%)    | 
|POLY-3 RATE (b)    |     0/0.81       0/1.00       0/2.60       0/4.88      |0/5.85       0/11.16      2/9.93       1/12.26      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         20.1%        8.2%         | 
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/1 (0%)     0/4 (0%)    |0/3 (0%)     0/9 (0%)     1/7 (14%)    0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          704          466          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.211      (e)          P=0.326      P=0.496      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.358      (e)          P=0.358      P=0.644      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.364      (e)          P=0.334      P=0.637      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.339      (e)          P=0.393      P=0.652      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.389      (e)          P=0.394      P=0.560      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.365      (e)          P=0.322      P=0.652      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.309      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/1 (0%)     0/3 (0%)     0/5 (0%)    |0/8 (0%)     3/12 (25%)   0/11 (0%)    1/15 (7%)    | 
|POLY-3 RATE (b)    |     0/0.81       0/1.00       0/2.60       0/4.88      |0/5.85       3/11.16      0/9.83       1/12.26      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         26.9%        0.0%         8.2%         | 
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/1 (0%)     0/4 (0%)    |0/3 (0%)     3/9 (33%)    0/7 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          466          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.629      P=0.356      (e)          P=0.496      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.419N     P=0.245      (e)          P=0.644      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.440N     P=0.218      (e)          P=0.637      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.398N     P=0.283      (e)          P=0.652      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.466N     P=0.356      (e)          P=0.560      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.475N     P=0.193      (e)          P=0.652      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.363N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     1/2 (50%)    5/8 (63%)    1/5 (20%)   |1/6 (17%)    2/9 (22%)    8/11 (73%)   4/9 (44%)    | 
|POLY-3 RATE (b)    |     0/0.00       1/1.61       5/7.82       1/4.88      |1/5.10       2/8.71       8/10.66      4/8.22       | 
|POLY-3 PERCENT (g) |     0.0%         62.0%        64.0%        20.5%       |19.6%        23.0%        75.1%        48.7%        | 
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   3/5 (60%)    0/3 (0%)    |1/3 (33%)    2/7 (29%)    7/9 (78%)    0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          730 (T)      585          568         |729 (T)      729 (T)      704          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.562N     P=1.000      P=0.244      P=0.508     |P=0.004 **   P=0.716N     P=0.130      P=0.104      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.131      P=0.688      P=0.045 *    P=0.317      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.134      P=0.668      P=0.036 *    P=0.306      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.122      P=0.716      P=0.065      P=0.332      | 
|LOGISTIC REGRESSION|     P=0.204N     P=1.000      (e)          (e)         |P=0.087      P=0.716N     P=0.106      P=0.292      | 
|COCH-ARM / FISHERS |     P=0.205N     P=1.000      P=1.000      P=1.000     |P=0.148      P=0.659      P=0.043 *    P=0.294      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.114      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/2 (0%)     0/8 (0%)     0/5 (0%)    |0/6 (0%)     0/9 (0%)     4/11 (36%)   0/9 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       0/1.61       0/7.14       0/4.35      |0/5.10       0/8.71       4/10.66      0/7.29       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         37.5%        0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/5 (0%)     0/3 (0%)    |0/3 (0%)     0/7 (0%)     3/9 (33%)    0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          704          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.317      (e)          P=0.185      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.518      (e)          P=0.162      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.566      (e)          P=0.147      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.416      (e)          P=0.189      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.434      (e)          P=0.195      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.598      (e)          P=0.139      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.212      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     1/2 (50%)    5/8 (63%)    2/5 (40%)   |1/6 (17%)    3/9 (33%)    7/11 (64%)   3/9 (33%)    | 
|POLY-3 RATE (b)    |     0/0.00       1/1.61       5/7.81       2/4.88      |1/5.51       3/8.71       7/10.90      3/8.02       | 
|POLY-3 PERCENT (g) |     0.0%         62.0%        64.1%        41.0%       |18.1%        34.5%        64.2%        37.4%        | 
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   3/5 (60%)    1/3 (33%)   |0/3 (0%)     3/7 (43%)    6/9 (67%)    0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          730 (T)      585          568         |608          729 (T)      634          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.510      P=1.000      P=0.244      P=0.508     |P=0.049 *    P=0.546      P=0.177      P=0.276      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.332      P=0.477      P=0.099      P=0.439      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.358      P=0.467      P=0.089      P=0.448      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.286      P=0.490      P=0.115      P=0.420      | 
|LOGISTIC REGRESSION|     P=0.455N     P=1.000      (e)          (e)         |P=0.420      P=0.359      P=0.052      P=0.454      | 
|COCH-ARM / FISHERS |     P=0.450N     P=1.000      P=1.000      P=1.000     |P=0.384      P=0.462      P=0.088      P=0.462      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.203      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     1/2 (50%)    3/8 (38%)    0/5 (0%)    |0/6 (0%)     1/9 (11%)    2/11 (18%)   1/9 (11%)    | 
|POLY-3 RATE (b)    |     0/0.00       1/1.61       3/7.33       0/4.35      |0/5.10       1/8.71       2/10.56      1/7.36       | 
|POLY-3 PERCENT (g) |     0.0%         62.0%        40.9%        0.0%        |0.0%         11.5%        18.9%        13.6%        | 
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   2/5 (40%)    0/3 (0%)    |0/3 (0%)     1/7 (14%)    2/9 (22%)    0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          730 (T)      679          ---         |---          729 (T)      729 (T)      712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.255N     P=1.000N     P=0.504      (e)         |P=0.163      P=0.669      P=0.500      P=0.455      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.412      P=0.604      P=0.408      P=0.574      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.432      P=0.593      P=0.393      P=0.577      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.371      P=0.619      P=0.430      P=0.563      | 
|LOGISTIC REGRESSION|     P=0.099N     P=1.000N     (e)          (e)         |P=0.217      P=0.669      P=0.500      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.126N     P=1.000      P=1.000      (e)         |P=0.448      P=0.600      P=0.404      P=0.600      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.370      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     1/2 (50%)    5/8 (63%)    0/5 (0%)    |1/6 (17%)    4/9 (44%)    9/11 (82%)   4/9 (44%)    | 
|POLY-3 RATE (b)    |     0/0.00       1/1.61       5/7.82       0/4.35      |1/5.10       4/8.71       9/11.00      4/8.22       | 
|POLY-3 PERCENT (g) |     0.0%         62.0%        64.0%        0.0%        |19.6%        45.9%        81.8%        48.7%        | 
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   3/5 (60%)    0/3 (0%)    |1/3 (33%)    4/7 (57%)    7/9 (78%)    0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          730 (T)      585          ---         |729 (T)      729 (T)      634          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.258N     P=1.000N     P=0.244      (e)         |P=0.011 *    P=0.500      P=0.073      P=0.104      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.279      P=0.350      P=0.017 *    P=0.317      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.271      P=0.323      P=0.010 *    P=0.306      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.282      P=0.391      P=0.036 *    P=0.332      | 
|LOGISTIC REGRESSION|     P=0.059N     P=1.000N     (e)          (e)         |P=0.203      P=0.500      P=0.032 *    P=0.292      | 
|COCH-ARM / FISHERS |     P=0.060N     P=1.000      P=1.000      (e)         |P=0.270      P=0.294      P=0.018 *    P=0.294      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.093      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/47.92      0/47.23      1/48.41      2/48.51     |1/46.52      0/46.76      1/46.73      1/43.42      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         2.1%         4.1%        |2.2%         0.0%         2.1%         2.3%         | 
|TERMINAL (d)       |     2/44 (5%)    0/44 (0%)    1/44 (2%)    2/45 (4%)   |1/40 (3%)    0/42 (0%)    0/41 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          730 (T)      730 (T)     |729 (T)      ---          718          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.477      P=0.238N     P=0.500N     P=0.686N    |P=0.473      P=0.490N     P=0.755N     P=0.704      | 
|POLY 3             |     P=0.477      P=0.241N     P=0.496N     P=0.689N    |P=0.516      P=0.499N     P=0.759N     P=0.745      | 
|POLY 1.5           |     P=0.474      P=0.239N     P=0.497N     P=0.690N    |P=0.525      P=0.500N     P=0.760      P=0.751      | 
|POLY 6             |     P=0.479      P=0.242N     P=0.496N     P=0.688N    |P=0.504      P=0.498N     P=0.758N     P=0.737      | 
|LOGISTIC REGRESSION|     P=0.477      (e)          P=0.500N     P=0.686N    |P=0.503      (e)          P=0.761N     P=0.704      | 
|COCH-ARM / FISHERS |     P=0.469      P=0.247N     P=0.500N     P=0.691N    |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.411N     (e)          (e)          (e)         |P=0.512      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      2/48.60      1/48.51     |1/46.94      0/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.1%         2.1%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    1/44 (2%)    1/45 (2%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          679          730 (T)     |606          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252      (e)          P=0.240      P=0.504     |P=0.312N     P=0.508N     P=0.504N     P=0.513N     | 
|POLY 3             |     P=0.252      (e)          P=0.241      P=0.502     |P=0.297N     P=0.501N     P=0.501N     P=0.516N     | 
|POLY 1.5           |     P=0.250      (e)          P=0.240      P=0.502     |P=0.301N     P=0.501N     P=0.501N     P=0.509N     | 
|POLY 6             |     P=0.254      (e)          P=0.241      P=0.503     |P=0.292N     P=0.501N     P=0.501N     P=0.523N     | 
|LOGISTIC REGRESSION|     P=0.240      (e)          P=0.223      P=0.504     |P=0.273N     P=0.479N     P=0.462N     P=0.439N     | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.170      (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    24/50 (48%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    39/50 (78%)  | 
|POLY-3 RATE (b)    |     0/47.92      2/47.23      2/48.41      24/48.51    |0/46.52      0/46.76      0/46.69      39/47.40     | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         4.1%         49.5%       |0.0%         0.0%         0.0%         82.3%        | 
|TERMINAL (d)       |     0/44 (0%)    2/44 (5%)    2/44 (5%)    24/45 (53%) |0/40 (0%)    0/42 (0%)    0/41 (0%)    27/31 (87%)  | 
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      730 (T)     |---          ---          ---          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.238      P=0.238      P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.234      P=0.240      P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.235      P=0.239      P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.233      P=0.240      P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|LOGISTIC REGRESSION|     (e)          P=0.238      P=0.238      P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.247      P=0.247      P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |48/49 (98%)  48/50 (96%)  46/50 (92%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |                                                        |48/49.00     48/48.98     46/48.31     45/48.37     | 
|POLY-3 PERCENT (g) |                                                        |98.0%        98.0%        95.2%        93.0%        | 
|TERMINAL (d)       |                                                        |39/40 (98%)  42/42 (100%) 40/41 (98%)  28/31 (90%)  | 
|FIRST INCIDENCE    |                                                        |456          522          478          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.057      P=0.402N     P=0.312N     P=0.136      | 
|POLY 3             |                                                        |P=0.106N     P=0.766      P=0.422N     P=0.241N     | 
|POLY 1.5           |                                                        |P=0.079N     P=0.709N     P=0.340N     P=0.183N     | 
|POLY 6             |                                                        |P=0.128N     P=0.737      P=0.513N     P=0.285N     | 
|LOGISTIC REGRESSION|                                                        |P=0.161N     P=0.635N     P=0.269N     P=0.200N     | 
|COCH-ARM / FISHERS |                                                        |P=0.056N     P=0.508N     P=0.187N     P=0.107N     | 
|ORDER RESTRICTED   |                                                        |P=0.144N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |22/49 (45%)  17/50 (34%)  17/50 (34%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |                                                        |22/46.99     17/48.31     17/48.05     14/44.98     | 
|POLY-3 PERCENT (g) |                                                        |46.8%        35.2%        35.4%        31.1%        | 
|TERMINAL (d)       |                                                        |18/40 (45%)  13/42 (31%)  14/41 (34%)  8/31 (26%)   | 
|FIRST INCIDENCE    |                                                        |610          316          478          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.278N     P=0.183N     P=0.195N     P=0.281N     | 
|POLY 3             |                                                        |P=0.097N     P=0.171N     P=0.177N     P=0.090N     | 
|POLY 1.5           |                                                        |P=0.085N     P=0.176N     P=0.184N     P=0.078N     | 
|POLY 6             |                                                        |P=0.110N     P=0.168N     P=0.169N     P=0.103N     | 
|LOGISTIC REGRESSION|                                                        |P=0.070N     P=0.182N     P=0.191N     P=0.093N     | 
|COCH-ARM / FISHERS |                                                        |P=0.064N     P=0.183N     P=0.183N     P=0.062N     | 
|ORDER RESTRICTED   |                                                        |P=0.093N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    5/50 (10%)   3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |2/46.76      5/48.31      3/46.69      4/44.46      | 
|POLY-3 PERCENT (g) |                                                        |4.3%         10.4%        6.4%         9.0%         | 
|TERMINAL (d)       |                                                        |0/40 (0%)    1/42 (2%)    3/41 (7%)    0/31 (0%)    | 
|FIRST INCIDENCE    |                                                        |606          316          729 (T)      536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.302      P=0.225      P=0.505      P=0.278      | 
|POLY 3             |                                                        |P=0.353      P=0.230      P=0.499      P=0.314      | 
|POLY 1.5           |                                                        |P=0.368      P=0.228      P=0.501      P=0.326      | 
|POLY 6             |                                                        |P=0.336      P=0.233      P=0.498      P=0.302      | 
|LOGISTIC REGRESSION|                                                        |P=0.506      P=0.281      P=0.513      P=0.441      | 
|COCH-ARM / FISHERS |                                                        |P=0.398      P=0.226      P=0.510      P=0.349      | 
|ORDER RESTRICTED   |                                                        |P=0.317      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/46.75      1/46.84      1/46.84      0/43.42      | 
|POLY-3 PERCENT (g) |                                                        |4.3%         2.1%         2.1%         0.0%         | 
|TERMINAL (d)       |                                                        |1/40 (3%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |                                                        |608          709          690          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.180N     P=0.497N     P=0.495N     P=0.275N     | 
|POLY 3             |                                                        |P=0.162N     P=0.499N     P=0.499N     P=0.254N     | 
|POLY 1.5           |                                                        |P=0.158N     P=0.498N     P=0.499N     P=0.246N     | 
|POLY 6             |                                                        |P=0.167N     P=0.500N     P=0.499N     P=0.264N     | 
|LOGISTIC REGRESSION|                                                        |P=0.135N     P=0.472N     P=0.465N     P=0.193N     | 
|COCH-ARM / FISHERS |                                                        |P=0.150N     P=0.492N     P=0.492N     P=0.242N     | 
|ORDER RESTRICTED   |                                                        |P=0.132N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    4/50 (8%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.33      4/46.94      2/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         8.5%         4.3%         0.0%         | 
|TERMINAL (d)       |                                                        |0/40 (0%)    2/42 (5%)    2/41 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          703          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.415N     P=0.069      P=0.244      (e)          | 
|POLY 3             |                                                        |P=0.373N     P=0.062      P=0.239      (e)          | 
|POLY 1.5           |                                                        |P=0.357N     P=0.062      P=0.239      (e)          | 
|POLY 6             |                                                        |P=0.391N     P=0.063      P=0.239      (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.366N     P=0.064      P=0.244      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.331N     P=0.061      P=0.253      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.191      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/49 (12%)   2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |6/46.33      2/47.08      3/46.69      1/43.42      | 
|POLY-3 PERCENT (g) |                                                        |13.0%        4.3%         6.4%         2.3%         | 
|TERMINAL (d)       |                                                        |6/40 (15%)   1/42 (2%)    3/41 (7%)    1/31 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      641          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.087N     P=0.121N     P=0.229N     P=0.107N     | 
|POLY 3             |                                                        |P=0.060N     P=0.128N     P=0.238N     P=0.067N     | 
|POLY 1.5           |                                                        |P=0.057N     P=0.129N     P=0.239N     P=0.062N     | 
|POLY 6             |                                                        |P=0.065N     P=0.126N     P=0.237N     P=0.074N     | 
|LOGISTIC REGRESSION|                                                        |P=0.065N     P=0.131N     P=0.229N     P=0.107N     | 
|COCH-ARM / FISHERS |                                                        |P=0.051N     P=0.128N     P=0.233N     P=0.053N     | 
|ORDER RESTRICTED   |                                                        |P=0.029N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      1/48.41      2/48.51     |1/46.52      2/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         4.1%        |2.2%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    1/44 (2%)    2/45 (4%)   |1/40 (3%)    2/42 (5%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      730 (T)     |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.073      (e)          P=0.500      P=0.243     |P=0.224N     P=0.517      P=0.495N     P=0.551N     | 
|POLY 3             |     P=0.072      (e)          P=0.502      P=0.240     |P=0.194N     P=0.502      P=0.499N     P=0.514N     | 
|POLY 1.5           |     P=0.072      (e)          P=0.501      P=0.239     |P=0.192N     P=0.501      P=0.500N     P=0.508N     | 
|POLY 6             |     P=0.073      (e)          P=0.502      P=0.241     |P=0.196N     P=0.503      P=0.498N     P=0.520N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      P=0.243     |P=0.224N     P=0.517      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.076      (e)          (e)          (e)         |P=0.182N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  11/50 (22%)  8/50 (16%)   8/50 (16%)  |20/50 (40%)  24/50 (48%)  33/50 (66%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     14/47.92     11/47.66     8/48.41      8/48.51     |20/46.52     24/47.39     33/47.09     18/44.27     | 
|POLY-3 PERCENT (g) |     29.2%        23.1%        16.5%        16.5%       |43.0%        50.6%        70.1%        40.7%        | 
|TERMINAL (d)       |     14/44 (32%)  10/44 (23%)  8/44 (18%)   8/45 (18%)  |20/40 (50%)  23/42 (55%)  31/41 (76%)  14/31 (45%)  | 
|FIRST INCIDENCE    |     730 (T)      606          730 (T)      730 (T)     |729 (T)      522          645          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.072N     P=0.323N     P=0.110N     P=0.100N    |P=0.217      P=0.338      P=0.007 **   P=0.373      | 
|POLY 3             |     P=0.075N     P=0.327N     P=0.106N     P=0.105N    |P=0.504N     P=0.295      P=0.005 **   P=0.495N     | 
|POLY 1.5           |     P=0.078N     P=0.326N     P=0.109N     P=0.108N    |P=0.458N     P=0.284      P=0.005 **   P=0.468N     | 
|POLY 6             |     P=0.074N     P=0.327N     P=0.105N     P=0.103N    |P=0.528      P=0.309      P=0.006 **   P=0.522N     | 
|LOGISTIC REGRESSION|     P=0.072N     P=0.341N     P=0.110N     P=0.100N    |P=0.490      P=0.282      P=0.006 **   P=0.566      | 
|COCH-ARM / FISHERS |     P=0.082N     P=0.322N     P=0.114N     P=0.114N    |P=0.378N     P=0.273      P=0.008 **   P=0.418N     | 
|ORDER RESTRICTED   |     P=0.095N     (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      1/47.23      1/48.41      1/48.51     |1/46.52      1/46.76      1/46.69      2/43.51      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.1%         2.1%        |2.2%         2.1%         2.1%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    1/44 (2%)    1/44 (2%)    1/45 (2%)   |1/40 (3%)    1/42 (2%)    1/41 (2%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      730 (T)     |729 (T)      729 (T)      729 (T)      705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.390      P=0.500      P=0.500      P=0.504     |P=0.270      P=0.751N     P=0.756N     P=0.418      | 
|POLY 3             |     P=0.391      P=0.497      P=0.502      P=0.502     |P=0.330      P=0.759N     P=0.760N     P=0.477      | 
|POLY 1.5           |     P=0.389      P=0.498      P=0.501      P=0.502     |P=0.338      P=0.760N     P=0.760      P=0.486      | 
|POLY 6             |     P=0.392      P=0.496      P=0.502      P=0.503     |P=0.320      P=0.758N     P=0.758N     P=0.466      | 
|LOGISTIC REGRESSION|     (e)          P=0.500      P=0.500      P=0.504     |P=0.308      P=0.751N     P=0.756N     P=0.462      | 
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.351      P=0.753N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.327      (e)          (e)          (e)         |P=0.383      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    0/38 (0%)    0/45 (0%)    0/36 (0%)   |0/42 (0%)    0/41 (0%)    3/40 (8%)    1/40 (3%)    | 
|POLY-3 RATE (b)    |     0/44.07      0/35.66      0/43.44      0/34.51     |0/39.91      0/38.68      3/38.82      1/35.97      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         7.7%         2.8%         | 
|TERMINAL (d)       |     0/41 (0%)    0/33 (0%)    0/40 (0%)    0/31 (0%)   |0/36 (0%)    0/34 (0%)    2/35 (6%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          704          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.189      (e)          P=0.118      P=0.496      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.208      (e)          P=0.113      P=0.479      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.218      (e)          P=0.111      P=0.484      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.193      (e)          P=0.115      P=0.473      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.362      (e)          P=0.113      P=0.908      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.236      (e)          P=0.112      P=0.488      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.109      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    4/50 (8%)    5/49 (10%)   3/47 (6%)    | 
|POLY-3 RATE (b)    |     0/45.92      0/46.80      0/48.41      0/48.51     |2/46.52      4/46.76      5/45.69      3/41.69      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         8.6%         10.9%        7.2%         | 
|TERMINAL (d)       |     0/42 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |2/40 (5%)    4/42 (10%)   5/40 (13%)   1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.309      P=0.359      P=0.216      P=0.401      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.389      P=0.340      P=0.209      P=0.450      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.403      P=0.338      P=0.207      P=0.459      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.372      P=0.342      P=0.211      P=0.439      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.376      P=0.359      P=0.216      P=0.458      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.425      P=0.339      P=0.210      P=0.470      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.320      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/48 (15%)   5/49 (10%)   5/50 (10%)   4/50 (8%)   |5/50 (10%)   3/50 (6%)    2/49 (4%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     7/45.92      5/47.22      5/48.63      4/48.51     |5/47.02      3/46.76      2/45.69      0/41.28      | 
|POLY-3 PERCENT (g) |     15.3%        10.6%        10.3%        8.3%        |10.6%        6.4%         4.4%         0.0%         | 
|TERMINAL (d)       |     7/42 (17%)   4/44 (9%)    4/44 (9%)    4/45 (9%)   |2/40 (5%)    3/42 (7%)    2/40 (5%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      606          671          730 (T)     |606          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202N     P=0.352N     P=0.349N     P=0.223N    |P=0.033N*    P=0.345N     P=0.225N     P=0.060N     | 
|POLY 3             |     P=0.203N     P=0.360N     P=0.340N     P=0.231N    |P=0.025N*    P=0.360N     P=0.228N     P=0.043N*    | 
|POLY 1.5           |     P=0.205N     P=0.362N     P=0.344N     P=0.234N    |P=0.023N*    P=0.359N     P=0.228N     P=0.040N*    | 
|POLY 6             |     P=0.202N     P=0.356N     P=0.336N     P=0.229N    |P=0.027N*    P=0.361N     P=0.229N     P=0.047N*    | 
|LOGISTIC REGRESSION|     P=0.204N     P=0.365N     P=0.342N     P=0.223N    |P=0.023N*    P=0.356N     P=0.225N     P=0.038N*    | 
|COCH-ARM / FISHERS |     P=0.208N     P=0.365N     P=0.351N     P=0.239N    |P=0.022N*    P=0.357N     P=0.226N     P=0.033N*    | 
|ORDER RESTRICTED   |     P=0.223N     (e)          (e)          (e)         |P=0.021N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |14/50 (28%)  14/50 (28%)  13/49 (27%)  3/47 (6%)    | 
|POLY-3 RATE (b)    |     1/45.92      1/46.80      0/48.41      0/48.51     |14/46.93     14/46.76     13/45.99     3/41.28      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         0.0%        |29.8%        29.9%        28.3%        7.3%         | 
|TERMINAL (d)       |     1/42 (2%)    1/44 (2%)    0/44 (0%)    0/45 (0%)   |13/40 (33%)  14/42 (33%)  12/40 (30%)  3/30 (10%)   | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |610          729 (T)      645          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.227N     P=0.751N     P=0.491N     P=0.486N    |P=0.015N*    P=0.531N     P=0.497N     P=0.017N*    | 
|POLY 3             |     P=0.229N     P=0.756N     P=0.489N     P=0.489N    |P=0.007N**   P=0.584      P=0.525N     P=0.006N**   | 
|POLY 1.5           |     P=0.229N     P=0.756N     P=0.490N     P=0.490N    |P=0.005N**   P=0.585      P=0.529N     P=0.005N**   | 
|POLY 6             |     P=0.229N     P=0.756N     P=0.489N     P=0.488N    |P=0.009N**   P=0.583      P=0.519N     P=0.008N**   | 
|LOGISTIC REGRESSION|     P=0.227N     P=0.751N     (e)          (e)         |P=0.008N**   P=0.576N     P=0.519N     P=0.009N**   | 
|COCH-ARM / FISHERS |     P=0.229N     P=0.747N     P=0.490N     P=0.490N    |P=0.004N**   P=0.588N     P=0.525N     P=0.005N**   | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |P=0.009N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/50 (42%)  23/50 (46%)  25/50 (50%)  32/50 (64%) |                                                    | 
|POLY-3 RATE (b)    |     21/47.92     23/47.72     25/49.29     32/50.00    |                                                    | 
|POLY-3 PERCENT (g) |     43.8%        48.2%        50.7%        64.0%       |                                                    | 
|TERMINAL (d)       |     21/44 (48%)  22/44 (50%)  22/44 (50%)  27/45 (60%) |                                                    | 
|FIRST INCIDENCE    |     730 (T)      585          589          568         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.022 *    P=0.418      P=0.277      P=0.036 *   |                                                    | 
|POLY 3             |     P=0.022 *    P=0.411      P=0.317      P=0.034 *   |                                                    | 
|POLY 1.5           |     P=0.018 *    P=0.415      P=0.300      P=0.028 *   |                                                    | 
|POLY 6             |     P=0.029 *    P=0.410      P=0.337      P=0.043 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.015 *    P=0.378      P=0.289      P=0.024 *   |                                                    | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.420      P=0.274      P=0.022 *   |                                                    | 
|ORDER RESTRICTED   |     P=0.030 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Duct                                                                                                            | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  15/50 (30%)  15/50 (30%)  28/50 (56%) |                                                    | 
|POLY-3 RATE (b)    |     20/48.66     15/47.37     15/49.06     28/49.57    |                                                    | 
|POLY-3 PERCENT (g) |     41.1%        31.7%        30.6%        56.5%       |                                                    | 
|TERMINAL (d)       |     19/44 (43%)  14/44 (32%)  13/44 (30%)  24/45 (53%) |                                                    | 
|FIRST INCIDENCE    |     463          695          589          568         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    P=0.202N     P=0.205N     P=0.109     |                                                    | 
|POLY 3             |     P=0.033 *    P=0.227N     P=0.191N     P=0.091     |                                                    | 
|POLY 1.5           |     P=0.030 *    P=0.218N     P=0.195N     P=0.086     |                                                    | 
|POLY 6             |     P=0.037 *    P=0.234N     P=0.185N     P=0.100     |                                                    | 
|LOGISTIC REGRESSION|     P=0.030 *    P=0.212N     P=0.206N     P=0.078     |                                                    | 
|COCH-ARM / FISHERS |     P=0.028 *    P=0.201N     P=0.201N     P=0.080     |                                                    | 
|ORDER RESTRICTED   |     P=0.015 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  43/50 (86%)  46/50 (92%)  28/50 (56%) |                                                    | 
|POLY-3 RATE (b)    |     32/48.95     43/49.13     46/49.78     28/48.51    |                                                    | 
|POLY-3 PERCENT (g) |     65.4%        87.5%        92.4%        57.7%       |                                                    | 
|TERMINAL (d)       |     29/44 (66%)  39/44 (89%)  41/44 (93%)  28/45 (62%) |                                                    | 
|FIRST INCIDENCE    |     540          449          585          730 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.066N     P=0.017 *    P=0.003 **   P=0.226N    |                                                    | 
|POLY 3             |     P=0.075N     P=0.007 **   P<0.001 **   P=0.284N    |                                                    | 
|POLY 1.5           |     P=0.070N     P=0.008 **   P<0.001 **   P=0.275N    |                                                    | 
|POLY 6             |     P=0.087N     P=0.006 **   P<0.001 **   P=0.303N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.063N     P=0.009 **   P<0.001 **   P=0.240N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.081N     P=0.010 *    P<0.001 **   P=0.270N    |                                                    | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  40/50 (80%)  40/50 (80%)  28/50 (56%) |27/50 (54%)  34/50 (68%)  30/50 (60%)  28/50 (56%)  | 
|POLY-3 RATE (b)    |     31/49.41     40/49.61     40/49.52     28/48.51    |27/47.17     34/49.71     30/48.60     28/45.55     | 
|POLY-3 PERCENT (g) |     62.8%        80.6%        80.8%        57.7%       |57.2%        68.4%        61.7%        61.5%        | 
|TERMINAL (d)       |     26/44 (59%)  35/44 (80%)  35/44 (80%)  28/45 (62%) |23/40 (58%)  28/42 (67%)  26/41 (63%)  21/31 (68%)  | 
|FIRST INCIDENCE    |     463          449          589          730 (T)     |610          316          204          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.066      P=0.069      P=0.305N    |P=0.136      P=0.191      P=0.393      P=0.113      | 
|POLY 3             |     P=0.175N     P=0.038 *    P=0.036 *    P=0.381N    |P=0.502      P=0.175      P=0.405      P=0.418      | 
|POLY 1.5           |     P=0.157N     P=0.038 *    P=0.037 *    P=0.363N    |P=0.525N     P=0.148      P=0.385      P=0.453      | 
|POLY 6             |     P=0.208N     P=0.037 *    P=0.035 *    P=0.414N    |P=0.432      P=0.205      P=0.415      P=0.367      | 
|LOGISTIC REGRESSION|     P=0.136N     P=0.041 *    P=0.039 *    P=0.323N    |P=0.496N     P=0.109      P=0.339      P=0.372      | 
|COCH-ARM / FISHERS |     P=0.143N     P=0.038 *    P=0.038 *    P=0.342N    |P=0.451N     P=0.109      P=0.343      P=0.500      | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |P=0.401      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/1 (0%)     0/2 (0%)     0/0 (0%)    |0/2 (0%)     3/4 (75%)    2/2 (100%)   0/4 (0%)     | 
|POLY-3 RATE (b)    |     0/0.71       0/0.61       0/1.82       0/0.00      |0/1.51       3/3.90       2/2.00       0/2.68       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         77.0%        100.0%       0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)    |0/0 (0%)     2/2 (100%)   2/2 (100%)   0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          709          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.184N     P=0.510      P=1.000N     (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.226N     P=0.240      P<0.001 **   (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.176N     P=0.198      P<0.001 **   (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.283N     P=0.319      P=0.058      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.254N     (e)          P=1.000N     (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.221N     P=0.200      P=0.167      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.116N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    4/50 (8%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      4/46.76      1/46.80      0/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         8.6%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    4/42 (10%)   0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      700          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.362N     P=0.070      P=0.500      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.318N     P=0.061      P=0.501      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.309N     P=0.061      P=0.500      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.329N     P=0.061      P=0.503      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.325N     P=0.070      P=0.501      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.059      P=0.500      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.163N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  7/50 (14%)   9/50 (18%)   14/50 (28%) |16/50 (32%)  35/50 (70%)  32/50 (64%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     11/49.74     7/49.05      9/49.53      14/49.86    |16/47.60     35/48.43     32/47.92     27/47.63     | 
|POLY-3 PERCENT (g) |     22.1%        14.3%        18.2%        28.1%       |33.6%        72.3%        66.8%        56.7%        | 
|TERMINAL (d)       |     7/44 (16%)   3/44 (7%)    4/44 (9%)    10/45 (22%) |11/40 (28%)  30/42 (71%)  28/41 (68%)  13/31 (42%)  | 
|FIRST INCIDENCE    |     463          449          585          568         |606          522          204          344          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.199      P=0.239N     P=0.404N     P=0.355     |P=0.010 *    P<0.001 **   P=0.004 **   P=0.008 **   | 
|POLY 3             |     P=0.169      P=0.228N     P=0.406N     P=0.326     |P=0.079      P<0.001 **   P<0.001 **   P=0.018 *    | 
|POLY 1.5           |     P=0.167      P=0.224N     P=0.405N     P=0.325     |P=0.084      P<0.001 **   P<0.001 **   P=0.018 *    | 
|POLY 6             |     P=0.172      P=0.231N     P=0.407N     P=0.328     |P=0.071      P<0.001 **   P<0.001 **   P=0.016 *    | 
|LOGISTIC REGRESSION|     P=0.088      P=0.118N     P=0.423N     P=0.253     |P=0.086      P<0.001 **   P<0.001 **   P=0.026 *    | 
|COCH-ARM / FISHERS |     P=0.164      P=0.218N     P=0.402N     P=0.322     |P=0.097      P<0.001 **   P<0.001 **   P=0.021 *    | 
|ORDER RESTRICTED   |     P=0.172      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      0/48.41      0/48.51     |0/46.52      0/46.76      0/46.69      2/43.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.224      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.225      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.229      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.220      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.054      (e)          (e)          P=0.262      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.025 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  31/50 (62%)  34/50 (68%)  32/50 (64%) |24/50 (48%)  36/50 (72%)  37/50 (74%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     17/48.27     31/48.15     34/48.64     32/48.51    |24/46.60     36/47.16     37/47.62     22/45.30     | 
|POLY-3 PERCENT (g) |     35.2%        64.4%        69.9%        66.0%       |51.5%        76.3%        77.7%        48.6%        | 
|TERMINAL (d)       |     15/44 (34%)  29/44 (66%)  32/44 (73%)  32/45 (71%) |23/40 (58%)  34/42 (81%)  34/41 (83%)  19/31 (61%)  | 
|FIRST INCIDENCE    |     679          585          679          730 (T)     |709          641          478          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.005 **   P<0.001 **   P=0.003 **  |P=0.304      P=0.017 *    P=0.007 **   P=0.295      | 
|POLY 3             |     P=0.004 **   P=0.003 **   P<0.001 **   P=0.002 **  |P=0.222N     P=0.008 **   P=0.005 **   P=0.471N     | 
|POLY 1.5           |     P=0.004 **   P=0.003 **   P<0.001 **   P=0.002 **  |P=0.200N     P=0.009 **   P=0.005 **   P=0.449N     | 
|POLY 6             |     P=0.003 **   P=0.003 **   P<0.001 **   P<0.001 **  |P=0.270N     P=0.008 **   P=0.005 **   P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.007 **   P=0.003 **   P<0.001 **   P=0.002 **  |P=0.332N     P=0.009 **   P=0.006 **   P=0.540N     | 
|COCH-ARM / FISHERS |     P=0.005 **   P=0.004 **   P<0.001 **   P=0.002 **  |P=0.184N     P=0.012 *    P=0.007 **   P=0.421N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.024N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.92      2/47.23      0/48.41      0/48.51     |1/46.94      0/46.76      0/46.69      1/43.75      | 
|POLY-3 PERCENT (g) |     2.1%         4.2%         0.0%         0.0%        |2.1%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/44 (2%)    2/44 (5%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |606          ---          ---          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185N     P=0.500      P=0.500N     P=0.496N    |P=0.586      P=0.508N     P=0.504N     P=0.751      | 
|POLY 3             |     P=0.187N     P=0.495      P=0.498N     P=0.498N    |P=0.584      P=0.501N     P=0.501N     P=0.745      | 
|POLY 1.5           |     P=0.187N     P=0.497      P=0.499N     P=0.498N    |P=0.588      P=0.501N     P=0.501N     P=0.751      | 
|POLY 6             |     P=0.186N     P=0.493      P=0.498N     P=0.497N    |P=0.580      P=0.501N     P=0.501N     P=0.737      | 
|LOGISTIC REGRESSION|     P=0.185N     P=0.500      (e)          (e)         |P=0.639      P=0.479N     P=0.462N     P=0.715N     | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.595      P=0.500N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.163N     (e)          (e)          (e)         |P=0.378      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.92      2/47.23      1/48.59      1/48.65     |1/46.94      1/46.86      1/47.03      1/43.75      | 
|POLY-3 PERCENT (g) |     2.1%         4.2%         2.1%         2.1%        |2.1%         2.1%         2.1%         2.3%         | 
|TERMINAL (d)       |     1/44 (2%)    2/44 (5%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      683          695         |606          703          634          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.520N     P=0.500      P=0.760      P=0.753N    |P=0.615      P=0.756      P=0.755N     P=0.751      | 
|POLY 3             |     P=0.524N     P=0.495      P=0.757N     P=0.757N    |P=0.608      P=0.760      P=0.760N     P=0.745      | 
|POLY 1.5           |     P=0.526N     P=0.497      P=0.758N     P=0.758N    |P=0.617      P=0.760      P=0.760      P=0.751      | 
|POLY 6             |     P=0.522N     P=0.493      P=0.757N     P=0.756N    |P=0.596      P=0.760      P=0.759N     P=0.737      | 
|LOGISTIC REGRESSION|     P=0.537N     P=0.500      P=0.755      P=0.759     |P=0.587N     P=0.758N     P=0.737N     P=0.715N     | 
|COCH-ARM / FISHERS |     P=0.530N     P=0.500      P=0.753N     P=0.753N    |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.577N     (e)          (e)          (e)         |P=0.725      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/47.92      2/47.23      1/48.59      1/48.51     |1/46.94      1/46.86      0/46.69      1/43.75      | 
|POLY-3 PERCENT (g) |     2.1%         4.2%         2.1%         2.1%        |2.1%         2.1%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/44 (2%)    2/44 (5%)    0/44 (0%)    1/45 (2%)   |0/40 (0%)    0/42 (0%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      683          730 (T)     |606          703          ---          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.522N     P=0.500      P=0.760      P=0.757N    |P=0.638N     P=0.756      P=0.504N     P=0.751      | 
|POLY 3             |     P=0.525N     P=0.495      P=0.757N     P=0.758N    |P=0.619N     P=0.760      P=0.501N     P=0.745      | 
|POLY 1.5           |     P=0.527N     P=0.497      P=0.758N     P=0.758N    |P=0.618N     P=0.760      P=0.501N     P=0.751      | 
|POLY 6             |     P=0.524N     P=0.493      P=0.757N     P=0.757N    |P=0.620N     P=0.760      P=0.501N     P=0.737      | 
|LOGISTIC REGRESSION|     P=0.527N     P=0.500      P=0.755      P=0.757N    |P=0.578N     P=0.758N     P=0.462N     P=0.715N     | 
|COCH-ARM / FISHERS |     P=0.530N     P=0.500      P=0.753N     P=0.753N    |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.577N     (e)          (e)          (e)         |P=0.552N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Glands                                                                                                       | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   13/50 (26%)  18/50 (36%)  5/50 (10%)  |18/50 (36%)  16/50 (32%)  22/50 (44%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     7/48.66      13/47.37     18/48.88     5/49.04     |18/46.52     16/46.76     22/46.80     10/44.20     | 
|POLY-3 PERCENT (g) |     14.4%        27.4%        36.8%        10.2%       |38.7%        34.2%        47.0%        22.6%        | 
|TERMINAL (d)       |     6/44 (14%)   12/44 (27%)  17/44 (39%)  4/45 (9%)   |18/40 (45%)  16/42 (38%)  21/41 (51%)  9/31 (29%)   | 
|FIRST INCIDENCE    |     463          695          589          568         |729 (T)      729 (T)      700          435          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252N     P=0.109      P=0.011 *    P=0.366N    |P=0.269N     P=0.342N     P=0.293      P=0.198N     | 
|POLY 3             |     P=0.248N     P=0.092      P=0.009 **   P=0.374N    |P=0.097N     P=0.407N     P=0.273      P=0.074N     | 
|POLY 1.5           |     P=0.254N     P=0.096      P=0.009 **   P=0.377N    |P=0.084N     P=0.413N     P=0.266      P=0.067N     | 
|POLY 6             |     P=0.241N     P=0.088      P=0.009 **   P=0.372N    |P=0.117N     P=0.400N     P=0.282      P=0.085N     | 
|LOGISTIC REGRESSION|     P=0.277N     P=0.105      P=0.009 **   P=0.439N    |P=0.137N     P=0.342N     P=0.265      P=0.094N     | 
|COCH-ARM / FISHERS |     P=0.271N     P=0.105      P=0.010 *    P=0.380N    |P=0.070N     P=0.417N     P=0.270      P=0.059N     | 
|ORDER RESTRICTED   |     P=0.034N*    (e)          (e)          (e)         |P=0.060N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Glands                                                                                                       | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    3/50 (6%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      1/48.41      1/48.51     |0/46.52      3/46.76      0/46.69      2/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         2.1%        |0.0%         6.4%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    1/44 (2%)    1/45 (2%)   |0/40 (0%)    3/42 (7%)    0/41 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      730 (T)     |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241      (e)          P=0.500      P=0.504     |P=0.265      P=0.130      (e)          P=0.184      | 
|POLY 3             |     P=0.241      (e)          P=0.502      P=0.502     |P=0.329      P=0.120      (e)          P=0.222      | 
|POLY 1.5           |     P=0.240      (e)          P=0.501      P=0.502     |P=0.336      P=0.119      (e)          P=0.228      | 
|POLY 6             |     P=0.243      (e)          P=0.502      P=0.503     |P=0.319      P=0.120      (e)          P=0.215      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      P=0.504     |(e)          P=0.130      (e)          P=0.184      | 
|COCH-ARM / FISHERS |     P=0.235      (e)          P=0.500      P=0.500     |P=0.351      P=0.121      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.254      (e)          (e)          (e)         |P=0.141      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    4/50 (8%)    12/50 (24%) |                                                    | 
|POLY-3 RATE (b)    |     0/47.92      1/47.23      4/48.44      12/49.08    |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         8.3%         24.5%       |                                                    | 
|TERMINAL (d)       |     0/44 (0%)    1/44 (2%)    3/44 (7%)    10/45 (22%) |                                                    | 
|FIRST INCIDENCE    |     ---          730 (T)      722          606         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.500      P=0.066      P<0.001 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.497      P=0.062      P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.498      P=0.062      P<0.001 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.496      P=0.062      P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.500      P=0.064      P<0.001 **  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.059      P<0.001 **  |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/47.92      3/47.23      1/48.41      2/48.94     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         6.4%         2.1%         4.1%        |                                                    | 
|TERMINAL (d)       |     0/44 (0%)    3/44 (7%)    1/44 (2%)    1/45 (2%)   |                                                    | 
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      606         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347      P=0.121      P=0.500      P=0.244     |                                                    | 
|POLY 3             |     P=0.347      P=0.116      P=0.502      P=0.242     |                                                    | 
|POLY 1.5           |     P=0.344      P=0.117      P=0.501      P=0.240     |                                                    | 
|POLY 6             |     P=0.350      P=0.115      P=0.502      P=0.244     |                                                    | 
|LOGISTIC REGRESSION|     P=0.323      P=0.121      P=0.500      P=0.173     |                                                    | 
|COCH-ARM / FISHERS |     P=0.337      P=0.121      P=0.500      P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.186      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/46 (26%)  9/48 (19%)   6/46 (13%)   5/47 (11%)  |8/46 (17%)   7/50 (14%)   3/50 (6%)    13/50 (26%)  | 
|POLY-3 RATE (b)    |     12/45.15     9/47.57      6/45.01      5/46.35     |8/44.27      7/49.39      3/47.22      13/45.70     | 
|POLY-3 PERCENT (g) |     26.6%        18.9%        13.3%        10.8%       |18.1%        14.2%        6.4%         28.5%        | 
|TERMINAL (d)       |     8/40 (20%)   5/43 (12%)   5/42 (12%)   3/43 (7%)   |4/38 (11%)   2/42 (5%)    0/41 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     540          449          683          656         |606          316          634          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033N*    P=0.290N     P=0.093N     P=0.051N    |P=0.060      P=0.470N     P=0.102N     P=0.103      | 
|POLY 3             |     P=0.031N*    P=0.265N     P=0.094N     P=0.045N*   |P=0.100      P=0.409N     P=0.079N     P=0.180      | 
|POLY 1.5           |     P=0.031N*    P=0.267N     P=0.093N     P=0.046N*   |P=0.107      P=0.417N     P=0.079N     P=0.193      | 
|POLY 6             |     P=0.031N*    P=0.264N     P=0.096N     P=0.046N*   |P=0.095      P=0.404N     P=0.080N     P=0.171      | 
|LOGISTIC REGRESSION|     P=0.054N     P=0.236N     P=0.112N     P=0.067N    |P=0.200      P=0.356N     P=0.072N     P=0.244      | 
|COCH-ARM / FISHERS |     P=0.032N*    P=0.272N     P=0.094N     P=0.048N*   |P=0.125      P=0.429N     P=0.076N     P=0.221      | 
|ORDER RESTRICTED   |     P=0.032N*    (e)          (e)          (e)         |P=0.032 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/46 (35%)  25/48 (52%)  20/46 (43%)  20/47 (43%) |23/46 (50%)  35/50 (70%)  31/50 (62%)  24/50 (48%)  | 
|POLY-3 RATE (b)    |     16/44.02     25/46.05     20/44.83     20/45.94    |23/44.27     35/48.16     31/48.80     24/45.91     | 
|POLY-3 PERCENT (g) |     36.4%        54.3%        44.6%        43.5%       |52.0%        72.7%        63.5%        52.3%        | 
|TERMINAL (d)       |     15/40 (38%)  24/43 (56%)  20/42 (48%)  20/43 (47%) |20/38 (53%)  31/42 (74%)  27/41 (66%)  18/31 (58%)  | 
|FIRST INCIDENCE    |     703          606          730 (T)      730 (T)     |606          561          204          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.505      P=0.083      P=0.321      P=0.354     |P=0.264      P=0.047 *    P=0.154      P=0.198      | 
|POLY 3             |     P=0.466      P=0.065      P=0.282      P=0.316     |P=0.313N     P=0.029 *    P=0.177      P=0.572      | 
|POLY 1.5           |     P=0.452      P=0.065      P=0.275      P=0.307     |P=0.274N     P=0.030 *    P=0.174      P=0.561N     | 
|POLY 6             |     P=0.478      P=0.065      P=0.289      P=0.324     |P=0.369N     P=0.030 *    P=0.176      P=0.529      | 
|LOGISTIC REGRESSION|     P=0.499      P=0.062      P=0.318      P=0.348     |P=0.280N     P=0.028 *    P=0.161      P=0.570      | 
|COCH-ARM / FISHERS |     P=0.424      P=0.069      P=0.261      P=0.289     |P=0.222N     P=0.036 *    P=0.164      P=0.503N     | 
|ORDER RESTRICTED   |     P=0.226      (e)          (e)          (e)         |P=0.223      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Ectopic Parathyroid Gland                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/46 (4%)    0/48 (0%)    0/46 (0%)    0/47 (0%)   |1/46 (2%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.02      0/45.62      0/44.83      0/45.94     |1/43.68      3/46.76      1/46.69      1/43.48      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |2.3%         6.4%         2.1%         2.3%         | 
|TERMINAL (d)       |     1/40 (3%)    0/43 (0%)    0/42 (0%)    0/43 (0%)   |1/38 (3%)    3/42 (7%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     703          ---          ---          ---         |729 (T)      729 (T)      729 (T)      714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113N     P=0.234N     P=0.234N     P=0.232N    |P=0.524N     P=0.342      P=0.745N     P=0.713      | 
|POLY 3             |     P=0.112N     P=0.229N     P=0.233N     P=0.228N    |P=0.450N     P=0.330      P=0.746N     P=0.760      | 
|POLY 1.5           |     P=0.112N     P=0.229N     P=0.235N     P=0.229N    |P=0.439N     P=0.332      P=0.745N     P=0.754N     | 
|POLY 6             |     P=0.112N     P=0.230N     P=0.232N     P=0.226N    |P=0.462N     P=0.329      P=0.746N     P=0.751      | 
|LOGISTIC REGRESSION|     P=0.114N     P=0.228N     P=0.239N     P=0.235N    |P=0.488N     P=0.342      P=0.745N     P=0.752      | 
|COCH-ARM / FISHERS |     P=0.114N     P=0.237N     P=0.247N     P=0.242N    |P=0.420N     P=0.341      P=0.731N     P=0.731N     | 
|ORDER RESTRICTED   |     P=0.026N*    (e)          (e)          (e)         |P=0.454N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    0/48 (0%)    0/46 (0%)    0/47 (0%)   |0/46 (0%)    8/50 (16%)   5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.92      0/45.62      0/44.83      0/45.94     |0/43.68      8/46.76      5/46.78      2/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         17.1%        10.7%        4.6%         | 
|TERMINAL (d)       |     0/40 (0%)    0/43 (0%)    0/42 (0%)    0/43 (0%)   |0/38 (0%)    8/42 (19%)   4/41 (10%)   2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      704          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.462      P=0.007 **   P=0.040 *    P=0.195      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.549      P=0.005 **   P=0.037 *    P=0.236      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.563N     P=0.005 **   P=0.037 *    P=0.243      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.511      P=0.005 **   P=0.036 *    P=0.227      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.506      P=0.007 **   P=0.039 *    P=0.195      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.515N     P=0.004 **   P=0.035 *    P=0.269      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/47.92      0/47.23      1/48.41      1/48.51     |0/46.52      1/46.76      2/46.78      2/43.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         2.1%        |0.0%         2.1%         4.3%         4.6%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    1/44 (2%)    1/45 (2%)   |0/40 (0%)    1/42 (2%)    1/41 (2%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          730 (T)      730 (T)     |---          729 (T)      704          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241      (e)          P=0.500      P=0.504     |P=0.106      P=0.510      P=0.240      P=0.184      | 
|POLY 3             |     P=0.241      (e)          P=0.502      P=0.502     |P=0.140      P=0.501      P=0.239      P=0.222      | 
|POLY 1.5           |     P=0.240      (e)          P=0.501      P=0.502     |P=0.148      P=0.500      P=0.237      P=0.228      | 
|POLY 6             |     P=0.243      (e)          P=0.502      P=0.503     |P=0.131      P=0.502      P=0.240      P=0.215      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      P=0.504     |P=0.129      P=0.510      P=0.238      P=0.184      | 
|COCH-ARM / FISHERS |     P=0.235      (e)          P=0.500      P=0.500     |P=0.160      P=0.500      P=0.247      P=0.247      | 
|ORDER RESTRICTED   |     P=0.254      (e)          (e)          (e)         |P=0.144      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/48.02      0/47.23      0/48.41      0/48.51     |0/46.52      1/47.08      2/47.40      0/43.42      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         0.0%         0.0%        |0.0%         2.1%         4.2%         0.0%         | 
|TERMINAL (d)       |     1/44 (2%)    0/44 (0%)    0/44 (0%)    0/45 (0%)   |0/40 (0%)    0/42 (0%)    1/41 (2%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     703          ---          ---          ---         |---          641          478          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.115N     P=0.242N     P=0.240N     P=0.237N    |P=0.648N     P=0.509      P=0.245      (e)          | 
|POLY 3             |     P=0.112N     P=0.241N     P=0.236N     P=0.235N    |P=0.644N     P=0.502      P=0.242      (e)          | 
|POLY 1.5           |     P=0.113N     P=0.240N     P=0.236N     P=0.236N    |P=0.633N     P=0.501      P=0.239      (e)          | 
|POLY 6             |     P=0.112N     P=0.243N     P=0.236N     P=0.235N    |P=0.629      P=0.504      P=0.244      (e)          | 
|LOGISTIC REGRESSION|     P=0.115N     P=0.238N     P=0.239N     P=0.239N    |P=0.558N     P=0.510      P=0.269      (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.616N     P=0.500      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.029N*    (e)          (e)          (e)         |P=0.329      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/48.02      0/47.23      0/48.41      1/48.51     |0/46.52      1/46.76      0/46.69      0/43.42      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         0.0%         2.1%        |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/44 (2%)    0/44 (0%)    0/44 (0%)    1/45 (2%)   |0/40 (0%)    1/42 (2%)    0/41 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     703          ---          ---          730 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.457N     P=0.242N     P=0.240N     P=0.495N    |P=0.609N     P=0.510      (e)          (e)          | 
|POLY 3             |     P=0.458N     P=0.241N     P=0.236N     P=0.496N    |P=0.568N     P=0.501      (e)          (e)          | 
|POLY 1.5           |     P=0.459N     P=0.240N     P=0.236N     P=0.497N    |P=0.568N     P=0.500      (e)          (e)          | 
|POLY 6             |     P=0.456N     P=0.243N     P=0.236N     P=0.496N    |P=0.567N     P=0.502      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.458N     P=0.238N     P=0.239N     P=0.498N    |(e)          P=0.510      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247N     P=0.247N     P=0.500N    |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.130N     (e)          (e)          (e)         |P=0.394N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  9/50 (18%)   6/50 (12%)   6/50 (12%)  |17/50 (34%)  19/50 (38%)  12/50 (24%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     12/48.02     9/47.37      6/49.08      6/48.51     |17/47.85     19/46.95     12/48.01     9/43.52      | 
|POLY-3 PERCENT (g) |     25.0%        19.0%        12.2%        12.4%       |35.5%        40.5%        25.0%        20.7%        | 
|TERMINAL (d)       |     11/44 (25%)  8/44 (18%)   4/44 (9%)    6/45 (13%)  |13/40 (33%)  18/42 (43%)  10/41 (24%)  8/31 (26%)   | 
|FIRST INCIDENCE    |     703          695          589          730 (T)     |606          680          204          704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062N     P=0.315N     P=0.102N     P=0.089N    |P=0.084N     P=0.480      P=0.182N     P=0.180N     | 
|POLY 3             |     P=0.059N     P=0.324N     P=0.086N     P=0.091N    |P=0.032N*    P=0.388      P=0.184N     P=0.089N     | 
|POLY 1.5           |     P=0.061N     P=0.319N     P=0.090N     P=0.092N    |P=0.025N*    P=0.400      P=0.184N     P=0.073N     | 
|POLY 6             |     P=0.058N     P=0.328N     P=0.083N     P=0.090N    |P=0.043N*    P=0.373      P=0.188N     P=0.114N     | 
|LOGISTIC REGRESSION|     P=0.061N     P=0.330N     P=0.097N     P=0.089N    |P=0.023N*    P=0.422      P=0.184N     P=0.077N     | 
|COCH-ARM / FISHERS |     P=0.065N     P=0.312N     P=0.096N     P=0.096N    |P=0.018N*    P=0.418      P=0.189N     P=0.055N     | 
|ORDER RESTRICTED   |     P=0.073N     (e)          (e)          (e)         |P=0.052N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 51      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/20 (5%)    0/31 (0%)    3/33 (9%)    0/21 (0%)   |0/21 (0%)    0/29 (0%)    0/24 (0%)    0/20 (0%)    | 
|POLY-3 RATE (b)    |     1/19.41      0/29.11      3/31.82      0/20.06     |0/20.57      0/28.41      0/23.48      0/18.14      | 
|POLY-3 PERCENT (g) |     5.2%         0.0%         9.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/19 (5%)    0/27 (0%)    2/29 (7%)    0/18 (0%)   |0/20 (0%)    0/26 (0%)    0/21 (0%)    0/13 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      ---          679          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.524N     P=0.430N     P=0.425      P=0.511N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.514N     P=0.418N     P=0.494      P=0.493N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.514N     P=0.416N     P=0.495      P=0.492N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.517N     P=0.421N     P=0.490      P=0.497N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.516N     (e)          P=0.497      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.516N     P=0.392N     P=0.512      P=0.488N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.365N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/20 (15%)   1/31 (3%)    3/33 (9%)    0/21 (0%)   |0/21 (0%)    0/29 (0%)    1/24 (4%)    0/20 (0%)    | 
|POLY-3 RATE (b)    |     3/19.41      1/29.11      3/31.82      0/20.06     |0/20.57      0/28.41      1/23.48      0/18.14      | 
|POLY-3 PERCENT (g) |     15.5%        3.4%         9.4%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     3/19 (16%)   1/27 (4%)    2/29 (7%)    0/18 (0%)   |0/20 (0%)    0/26 (0%)    1/21 (5%)    0/13 (0%)    | 
|FIRST INCIDENCE    |     730 (T)      730 (T)      679          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.133N     P=0.186N     P=0.491N     P=0.127N    |P=0.648      (e)          P=0.510      (e)          | 
|POLY 3             |     P=0.113N     P=0.167N     P=0.421N     P=0.105N    |P=0.649      (e)          P=0.526      (e)          | 
|POLY 1.5           |     P=0.114N     P=0.164N     P=0.419N     P=0.104N    |P=0.664      (e)          P=0.527      (e)          | 
|POLY 6             |     P=0.114N     P=0.171N     P=0.425N     P=0.107N    |P=0.626      (e)          P=0.525      (e)          | 
|LOGISTIC REGRESSION|     P=0.118N     P=0.186N     P=0.419N     (e)         |(e)          (e)          P=0.510      (e)          | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.161N     P=0.406N     P=0.107N    |P=0.685      (e)          P=0.533      (e)          | 
|ORDER RESTRICTED   |     P=0.067N     (e)          (e)          (e)         |P=0.405      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 52      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Gingiva                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/20 (90%)  30/31 (97%)  32/33 (97%)  20/21 (95%) |21/21 (100%) 29/29 (100%) 24/24 (100%) 20/20 (100%) | 
|POLY-3 RATE (b)    |     18/20.00     30/31.00     32/33.00     20/21.00    |21/21.00     29/29.00     24/24.00     20/20.00     | 
|POLY-3 PERCENT (g) |     90.0%        96.8%        97.0%        95.2%       |100.0%       100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     17/19 (90%)  26/27 (96%)  28/29 (97%)  17/18 (94%) |20/20 (100%) 26/26 (100%) 21/21 (100%) 13/13 (100%) | 
|FIRST INCIDENCE    |     540          449          585          568         |606          641          645          466          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.293      P=0.105      P=0.100      P=0.239     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.417      P=0.348      P=0.327      P=0.483     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.417      P=0.348      P=0.327      P=0.483     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.417      P=0.348      P=0.327      P=0.483     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.416      P=0.338      P=0.316      P=0.481     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.313      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     24/50 (48%)  24/50 (48%)  32/50 (64%)  23/50 (46%) |37/50 (74%)  38/49 (78%)  40/50 (80%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     24/48.07     24/47.85     32/49.59     23/48.51    |37/47.60     38/48.08     40/48.52     39/46.58     | 
|POLY-3 PERCENT (g) |     49.9%        50.2%        64.5%        47.4%       |77.7%        79.0%        82.4%        83.7%        | 
|TERMINAL (d)       |     23/44 (52%)  22/44 (50%)  29/44 (66%)  23/45 (51%) |32/40 (80%)  33/41 (81%)  35/41 (85%)  27/31 (87%)  | 
|FIRST INCIDENCE    |     690          585          585          730 (T)     |606          316          478          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.478N     P=0.578      P=0.084      P=0.457N    |P=0.012 *    P=0.564      P=0.398      P=0.031 *    | 
|POLY 3             |     P=0.497N     P=0.572      P=0.103      P=0.483N    |P=0.243      P=0.537      P=0.371      P=0.310      | 
|POLY 1.5           |     P=0.506N     P=0.574      P=0.093      P=0.487N    |P=0.286      P=0.500      P=0.336      P=0.347      | 
|POLY 6             |     P=0.495N     P=0.572      P=0.114      P=0.483N    |P=0.194      P=0.566      P=0.403      P=0.261      | 
|LOGISTIC REGRESSION|     P=0.483N     P=0.542      P=0.086      P=0.465N    |P=0.237      P=0.428      P=0.310      P=0.230      | 
|COCH-ARM / FISHERS |     P=0.529N     P=0.579N     P=0.079      P=0.500N    |P=0.369      P=0.430      P=0.318      P=0.408      | 
|ORDER RESTRICTED   |     P=0.360N     (e)          (e)          (e)         |P=0.359      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/01/04                           EXPERIMENT: 88138 TEST: 04                                            Page 53      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/49 (10%)   4/50 (8%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |5/46.83      4/46.76      2/46.84      2/43.42      | 
|POLY-3 PERCENT (g) |                                                        |10.7%        8.6%         4.3%         4.6%         | 
|TERMINAL (d)       |                                                        |3/40 (8%)    4/42 (10%)   1/41 (2%)    2/31 (7%)    | 
|FIRST INCIDENCE    |                                                        |608          729 (T)      690          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.204N     P=0.478N     P=0.217N     P=0.316N     | 
|POLY 3             |                                                        |P=0.149N     P=0.501N     P=0.216N     P=0.248N     | 
|POLY 1.5           |                                                        |P=0.141N     P=0.497N     P=0.215N     P=0.233N     | 
|POLY 6             |                                                        |P=0.158N     P=0.505N     P=0.217N     P=0.268N     | 
|LOGISTIC REGRESSION|                                                        |P=0.144N     P=0.490N     P=0.204N     P=0.227N     | 
|COCH-ARM / FISHERS |                                                        |P=0.127N     P=0.487N     P=0.210N     P=0.210N     | 
|ORDER RESTRICTED   |                                                        |P=0.199N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |47/49 (96%)  45/50 (90%)  44/50 (88%)  43/50 (86%)  | 
|POLY-3 RATE (b)    |                                                        |47/47.84     45/48.90     44/49.35     43/48.18     | 
|POLY-3 PERCENT (g) |                                                        |98.3%        92.0%        89.2%        89.3%        | 
|TERMINAL (d)       |                                                        |40/40 (100%) 40/42 (95%)  39/41 (95%)  29/31 (94%)  | 
|FIRST INCIDENCE    |                                                        |606          522          204          400          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.066      P=0.215N     P=0.215N     P=0.147      | 
|POLY 3             |                                                        |P=0.072N     P=0.154N     P=0.061N     P=0.059N     | 
|POLY 1.5           |                                                        |P=0.072N     P=0.189N     P=0.085N     P=0.068N     | 
|POLY 6             |                                                        |P=0.080N     P=0.115N     P=0.046N*    P=0.053N     | 
|LOGISTIC REGRESSION|                                                        |P=0.152N     P=0.280N     P=0.174N     P=0.203N     | 
|COCH-ARM / FISHERS |                                                        |P=0.080N     P=0.226N     P=0.141N     P=0.085N     | 
|ORDER RESTRICTED   |                                                        |P=0.059N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).