National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17701

TDMS Study 88138-04 Pathology Tables

NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06

                                                          FINAL#2 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  04/26/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            2            5            6                                     
    Natural Death                                      6            6            4           12                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           42           41           31                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (49)         (50)         (50)         (50)                                   
      Cyst                                                          1 [2.0]      1 [2.0]                                            
      Infiltration Cellular, Lymphoid                                            1 [2.0]                                            
      Inflammation, Chronic Active                     1 [2.0]                   1 [2.0]      1 [1.0]                               
      Mineralization                                                             1 [1.0]                                            
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            1 [2.0]                               
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 [3.0]                                            
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          3 [3.0]                   1 [4.0]                               
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                          1 [4.0]                                                         
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 [2.5]                   1 [2.0]      4 [2.3]                               
      Basophilic Focus                                 3                         1            2                                     
      Clear Cell Focus                                 3            2            4            4                                     
      Eosinophilic Focus                               2            2            7            7                                     
      Hematopoietic Cell Proliferation                18 [1.3]     11 [1.1]     20 [1.3]     19 [1.1]                               
      Infarct                                                                                 1 [4.0]                               
      Infiltration Cellular, Lymphoid                 36 [1.2]     38 [1.2]     35 [1.2]     35 [1.2]                               
      Inflammation, Chronic Active                    44 [1.1]     40 [1.1]     41 [1.0]     36 [1.1]                               
      Mineralization                                                             1 [2.0]                                            
      Mixed Cell Focus                                 2            5            3            2                                     
      Tension Lipidosis                                4 [1.3]      8 [1.5]      3 [1.7]      7 [1.1]                               
      Bile Duct, Hyperplasia                           1 [1.0]                                                                      
      Hepatocyte, Autolysis                                                                   1                                     
      Hepatocyte, Mitotic Alteration                                             1 [2.0]                                            
      Hepatocyte, Multinucleated                                                              2 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Necrosis                             3 [2.0]      5 [2.0]      4 [1.5]                                            
      Hepatocyte, Vacuolization Cytoplasmic           41 [1.1]     43 [1.0]     39 [1.0]     34 [1.2]                               
      Hepatocyte, Centrilobular, Degeneration                                                 1 [4.0]                               
      Hepatocyte, Centrilobular, Hypertrophy                       29 [2.0]     44 [2.0]     37 [2.9]                               
   Mesentery                                          (6)          (9)          (11)         (9)                                    
      Fat, Fibrosis                                    1 [2.0]      2 [2.0]      8 [2.0]      4 [2.0]                               
      Fat, Hemorrhage                                                                         1 [4.0]                               
      Fat, Infiltration Cellular, Lymphoid                                       4 [2.3]                                            
      Fat, Inflammation, Chronic Active                1 [4.0]      3 [2.0]      7 [2.0]      3 [1.7]                               
      Fat, Mineralization                                           1 [2.0]      2 [1.5]      1 [1.0]                               
      Fat, Necrosis                                    1 [4.0]      4 [4.0]      9 [4.0]      4 [4.0]                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Cyst                                             1 [3.0]      2 [3.5]                                                         
      Infiltration Cellular, Lymphoid                 20 [1.1]     24 [1.0]     33 [1.2]     18 [1.3]                               
      Acinus, Atrophy                                  1 [4.0]      1 [4.0]      1 [4.0]      2 [4.0]                               
      Acinus, Cytoplasmic Alteration                                1 [1.0]                                                         
      Duct, Inflammation, Chronic Active                                         1 [3.0]                                            
      Duct, Pigmentation                                                         1 [3.0]                                            
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 27 [1.1]     34 [1.2]     30 [1.3]     28 [1.1]                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 [3.0]                                1 [2.0]                               
      Epithelium, Hyperkeratosis                       1 [2.0]      1 [2.0]      1 [2.0]      1 [1.0]                               
      Epithelium, Hyperplasia, Squamous                1 [2.0]      1 [3.0]                   1 [2.0]                               
      Epithelium, Ulcer                                1 [4.0]                                1 [2.0]                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Epithelium, Glands, Hyperplasia                  1 [2.0]                                                                      
      Glands, Ectasia                                 18 [1.0]     16 [1.2]     22 [1.2]     10 [1.3]                               
      Glands, Mineralization                                        3 [1.0]                   2 [1.0]                               
   Tooth                                              (21)         (29)         (24)         (20)                                   
      Malformation                                                               1                                                  
      Gingiva, Inflammation, Chronic Active           21 [1.6]     29 [1.8]     24 [1.7]     20 [1.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Mineralization                                                                   1 [2.0]                               
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                             1 [2.0]                                            
      Hyperplasia, Atypical                                                      1 [2.0]      1 [4.0]                               
      Inflammation, Chronic Active                     2 [1.5]      1 [1.0]      1 [2.0]                                            
      Mineralization                                                             1 [2.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Necrosis                                         1 [3.0]                                                                      
      Valve, Inflammation, Chronic Active              1 [4.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule                1 [2.0]                                1 [1.0]                               
      Hematopoietic Cell Proliferation                 1 [2.0]                                1 [2.0]                               
      Hemorrhage                                                                              1 [4.0]                               
      Hyperplasia                                      2 [1.0]                                                                      
      Hypertrophy                                      1 [1.0]      1 [2.0]                                                         
      Inflammation, Chronic Active                     1 [2.0]                                                                      
      Mineralization                                                                          1 [2.0]                               
      Necrosis                                                      1 [2.0]                   1 [1.0]                               
      Subcapsular, Hyperplasia                        49 [1.8]     49 [1.9]     49 [1.8]     49 [1.8]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                                2 [1.5]                                            
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      3 [2.0]      1 [2.0]                                                         
   Parathyroid Gland                                  (42)         (41)         (40)         (40)                                   
      Cyst                                                                       3 [2.0]      1 [2.0]                               
   Pituitary Gland                                    (50)         (50)         (49)         (47)                                   
      Pars Distalis, Angiectasis                       2 [2.5]      4 [1.5]      5 [1.8]      3 [2.7]                               
      Pars Distalis, Cyst                              5 [1.0]      3 [2.0]      2 [1.0]                                            
      Pars Distalis, Hyperplasia                      14 [1.9]     14 [2.1]     13 [2.2]      3 [2.7]                               
      Pars Distalis, Hypertrophy                                                 1 [1.0]                                            
      Pars Distalis, Pigmentation                                                1 [1.0]                                            
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                               1 [1.0]      2 [1.0]      2 [1.5]                               
      Inflammation, Chronic Active                                  1 [2.0]      2 [1.5]                                            
      C-Cell, Hyperplasia                                                                     1 [1.0]                               
      Follicle, Cyst                                                1 [2.0]                                                         
      Follicle, Degeneration                          17 [1.1]     19 [1.4]     12 [1.3]      9 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Clitoral Gland                                     (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                     8 [2.1]      1 [1.0]                   2 [1.5]                               
      Duct, Cyst                                       1 [2.0]                                                                      
   Ovary                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [2.0]      1 [2.0]                                                         
      Atrophy                                         48 [3.9]     48 [3.7]     46 [3.8]     45 [4.0]                               
      Cyst                                            22 [2.6]     17 [2.6]     17 [2.9]     14 [2.7]                               
      Hemorrhage                                       2 [4.0]      5 [4.0]      3 [4.0]      4 [4.0]                               
      Infiltration Cellular, Lymphoid                                                         1 [4.0]                               
      Inflammation, Chronic Active                     2 [3.5]      1 [2.0]      1 [4.0]                                            
      Mineralization                                                4 [1.8]      2 [2.0]                                            
      Pigmentation                                     6 [1.2]      2 [1.0]      3 [1.7]      1 [1.0]                               
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [2.0]                   1 [3.0]                                            
      Inflammation, Chronic Active                     5 [2.2]      4 [2.0]      2 [3.5]      2 [2.0]                               
      Endometrium, Hyperplasia, Cystic                47 [2.2]     45 [2.4]     44 [2.3]     43 [2.1]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Myelofibrosis                                   18 [1.6]     30 [1.5]     20 [1.5]     26 [1.6]                               
      Myeloid Cell, Hyperplasia                        1 [4.0]                                                                      
   Lymph Node                                         (8)          (12)         (11)         (15)                                   
      Lumbar, Hyperplasia, Lymphoid                    1 [3.0]      1 [3.0]                   2 [3.0]                               
      Mediastinal, Atrophy                             1 [3.0]                                                                      
      Mediastinal, Hyperplasia, Lymphoid               2 [2.5]      5 [2.8]      4 [3.5]      4 [2.0]                               
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                     1 [3.0]                                                                      
      Mediastinal, Inflammation, Chronic Active        1 [3.0]                                                                      
      Pancreatic, Hyperplasia, Lymphoid                                          2 [4.0]      1 [4.0]                               
      Pancreatic, Pigmentation                                                   1 [2.0]                                            
      Renal, Hemorrhage                                             1 [4.0]                   1 [3.0]                               
      Renal, Hyperplasia, Lymphoid                                  3 [4.0]                   1 [4.0]                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
      Hyperplasia, Lymphoid                            4 [2.3]     20 [2.9]     12 [2.8]      9 [2.7]                               
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)                                   
      Hyperplasia, Lymphoid                            6 [3.3]     12 [3.3]      6 [3.2]      4 [2.5]                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                16 [2.6]     35 [2.1]     32 [2.4]     27 [2.8]                               
      Hemorrhage                                                                              2 [4.0]                               
      Inflammation, Chronic Active                                                            1 [2.0]                               
      Necrosis                                                                                1 [4.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Lymphoid Follicle, Hyperplasia, Lymphoid        24 [2.5]     36 [2.5]     37 [2.7]     22 [2.9]                               
   Thymus                                             (46)         (50)         (50)         (50)                                   
      Atrophy                                          8 [3.5]      7 [3.1]      3 [4.0]     13 [3.2]                               
      Cyst                                            23           35           31           24                                     
      Ectopic Parathyroid Gland                        1 [2.0]      3 [1.3]      1 [2.0]      1 [1.0]                               
      Hyperplasia, Lymphoid                                         8 [3.0]      5 [3.0]      2 [2.0]                               
      Infiltration Cellular, Mast Cell                                           1 [3.0]                                            
      Inflammation, Chronic Active                     1 [3.0]                                                                      
      Thymocyte, Necrosis                                           1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosis                                 1 [3.0]                                                         
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
         Lymphoid                                                   4 [1.0]      1 [2.0]                                            
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
         Polymorphonuclear                             1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Maxilla, Fracture                                                                       1                                     
   Skeletal Muscle                                    (2)          (4)          (2)          (4)                                    
      Infiltration Cellular, Lymphoid                               3 [1.0]      2 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              2 [2.0]                               
      Infiltration Cellular, Lymphoid                               1 [2.0]      2 [2.0]                                            
      Inflammation, Chronic Active                                                            1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1                                                                            
      Infiltration Cellular, Lymphoid                 33 [1.3]     44 [1.5]     44 [1.6]     35 [1.4]                               
      Inflammation, Chronic Active                                  1 [1.0]      1 [2.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Metaplasia, Osseous                                                                     1 [1.0]                               
      Pigmentation                                                                            2 [2.5]                               
      Alveolar Epithelium, Hyperplasia                 1 [2.0]      1 [2.0]      2 [3.0]      2 [1.0]                               
      Alveolus, Hemorrhage                             2 [2.0]                                3 [1.7]                               
      Alveolus, Infiltration Cellular, Histiocyte      1 [4.0]                                2 [2.5]                               
      Mediastinum, Inflammation, Chronic Active        1 [3.0]                                                                      
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 [3.0]                               
      Inflammation, Chronic Active                     1 [1.0]                   1 [2.0]      1 [2.0]                               
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
        Active                                         1 [2.0]                                                                      
      Olfactory Epithelium, Metaplasia                                                       39 [1.7]                               
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Glands, Cyst                                                  1 [2.0]                                                         
      Glands, Inflammation, Chronic Active                          1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 [4.0]                                                                      
      Lens, Cataract                                                             1 [3.0]                                            
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                   3 [2.7]      3 [2.0]      1 [2.0]                               
      Infiltration Cellular, Lymphoid                 29 [1.0]     27 [1.0]     27 [1.0]     23 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                              1 [3.0]      1 [4.0]                               
      Atrophy                                          1 [3.0]                                                                      
      Glomerulosclerosis                                                                      1 [4.0]                               
      Hydronephrosis                                   2 [2.5]                                1 [3.0]                               
      Infarct                                          4 [2.8]      1 [1.0]      3 [2.7]      3 [2.7]                               
      Infiltration Cellular, Lymphoid                 41 [1.1]     45 [1.2]     43 [1.3]     39 [1.3]                               
      Inflammation, Chronic Active                     1 [3.0]                                                                      
      Metaplasia, Osseous                              1 [3.0]      2 [1.5]      4 [1.0]      2 [1.5]                               
      Mineralization                                  15 [1.0]     31 [1.0]     36 [1.1]     49 [1.5]                               
      Nephropathy                                     21 [1.2]     33 [1.1]     31 [1.5]     30 [1.7]                               
      Artery, Inflammation, Chronic Active             1 [2.0]                                1 [3.0]                               
      Cortex, Cyst                                                  1                                                               
      Renal Tubule, Pigmentation                       1 [3.0]      1 [3.0]      1 [2.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Urinary Bladder                                    (50)         (49)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 37 [1.2]     38 [1.2]     40 [1.2]     39 [1.0]                               
      Inflammation, Chronic Active                                                            1 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            3            5            2                                     
    Natural Death                                      1            3            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           44           44           45                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (49)         (49)         (49)                                   
      Cyst                                                                       1 [2.0]                                            
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 [2.0]                                            
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 4            2            5                                                  
      Clear Cell Focus                                 2            7            7           12                                     
      Eosinophilic Focus                               5            8           11           10                                     
      Fatty Change                                                               1 [4.0]                                            
      Fibrosis                                                                   1 [2.0]                                            
      Hematopoietic Cell Proliferation                 2 [1.0]      1 [2.0]                                                         
      Infarct                                                       2 [4.0]                   1 [4.0]                               
      Infiltration Cellular, Lymphoid                  6 [1.2]     10 [1.3]                   4 [1.0]                               
      Inflammation, Chronic Active                    33 [1.0]     47 [1.1]     44 [1.2]     42 [1.1]                               
      Mixed Cell Focus                                 8            9           15           13                                     
      Tension Lipidosis                                1            1                         1                                     
      Bile Duct, Cyst                                               3                         1                                     
      Hepatocyte, Degeneration, Cystic                                           5 [1.2]     30 [1.9]                               
      Hepatocyte, Multinucleated                                   41 [1.4]     47 [1.5]     48 [1.8]                               
      Hepatocyte, Necrosis                             1 [1.0]      6 [1.7]      8 [1.8]      8 [1.3]                               
      Hepatocyte, Vacuolization Cytoplasmic           44 [1.0]     45 [1.4]     46 [1.8]     44 [1.4]                               
      Hepatocyte, Centrilobular, Hypertrophy                       44 [2.0]     50 [2.0]     48 [3.0]                               
      Oval Cell, Hyperplasia                                                     1 [2.0]                                            
   Mesentery                                                       (2)          (8)          (5)                                    
      Fat, Fibrosis                                                 1 [3.0]      5 [2.4]      1 [3.0]                               
      Fat, Inflammation, Chronic Active                             1 [2.0]      5 [2.2]      2 [1.5]                               
      Fat, Mineralization                                           1 [1.0]      3 [1.3]                                            
      Fat, Necrosis                                                 1 [4.0]      5 [4.0]                                            
      Fat, Pigmentation                                             1 [3.0]                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst                                                                       1 [2.0]      2 [2.5]                               
      Cytoplasmic Alteration                           1 [2.0]                                                                      
      Infiltration Cellular, Lymphoid                 14 [1.0]     11 [1.0]      8 [1.1]      8 [1.0]                               
      Acinus, Atrophy                                               1 [1.0]      1 [4.0]      1 [3.0]                               
      Acinus, Cytoplasmic Alteration                                             1 [2.0]                                            
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 [4.0]                                                         
      Infiltration Cellular, Lymphoid                 31 [1.1]     40 [1.0]     40 [1.1]     28 [1.0]                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 [3.0]                                                         
      Inflammation, Chronic Active                     1 [3.0]      2 [3.0]                                                         
      Epithelium, Cyst                                              1 [2.0]                                                         
      Epithelium, Hyperkeratosis                       1 [2.0]      2 [2.0]      1 [4.0]      1 [2.0]                               
      Epithelium, Hyperplasia, Squamous                1 [3.0]      2 [2.5]      1 [2.0]      1 [1.0]                               
      Epithelium, Ulcer                                1 [4.0]      1 [3.0]                                                         
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Glands, Ectasia                                  7 [1.1]     13 [1.2]     18 [1.1]      5 [1.0]                               
      Glands, Mineralization                                                     1 [2.0]      1 [1.0]                               
   Tooth                                              (20)         (31)         (33)         (21)                                   
      Inflammation, Chronic Active                     1 [3.0]                   3 [3.3]                                            
      Malformation                                     3 [3.0]      1 [3.0]      3 [4.0]                                            
      Gingiva, Inflammation, Chronic Active           18 [1.7]     30 [1.8]     32 [1.6]     20 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hyperplasia, Atypical                                                                   1 [2.0]                               
      Inflammation, Chronic Active                     3 [1.0]      5 [1.2]      3 [2.7]      3 [1.3]                               
      Mineralization                                   1 [1.0]                                1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Degeneration, Fatty                                                        2 [1.0]                                            
      Hyperplasia                                      7 [1.7]     10 [1.6]      9 [1.8]      6 [1.8]                               
      Hypertrophy                                     26 [1.3]     22 [1.4]     24 [1.4]     18 [1.5]                               
      Inflammation, Chronic Active                                               1 [1.0]                                            
      Necrosis                                                      1 [3.0]                                                         
      Subcapsular, Hyperplasia                        50 [1.1]     46 [1.2]     46 [1.1]     47 [1.1]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 [2.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 [2.0]      1 [2.0]                                                         
   Pituitary Gland                                    (48)         (49)         (50)         (50)                                   
      Pars Distalis, Cyst                              7 [1.4]      5 [1.4]      5 [1.6]      4 [1.3]                               
      Pars Distalis, Hyperplasia                       1 [1.0]      1 [2.0]                                                         
      Pars Nervosa, Cyst                                            1 [2.0]                                                         
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                                            1 [2.0]      1 [1.0]                               
      Inflammation, Chronic Active                     2 [1.0]                                                                      
      Follicle, Cyst                                   2 [2.5]                                1 [2.0]                               
      Follicle, Degeneration                          12 [1.1]      9 [1.0]      6 [1.0]      6 [1.3]                               
      Follicular Cell, Hyperplasia                                               1 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Degeneration                                                  1 [4.0]                                                         
      Granuloma Sperm                                  1 [2.0]      2 [2.0]      2 [2.5]      1 [2.0]                               
      Infiltration Cellular, Lymphoid                 32 [1.1]     27 [1.0]     30 [1.1]     31 [1.0]                               
      Mineralization                                                             4 [1.5]                                            
      Spermatocele                                                               1 [2.0]                                            
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                    21 [1.1]     23 [1.2]     25 [1.4]     32 [1.1]                               
      Duct, Ectasia                                   20 [2.2]     15 [2.4]     15 [2.3]     28 [2.3]                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 32 [1.0]     43 [1.0]     46 [1.0]     28 [1.0]                               
      Inflammation, Chronic Active                     1 [1.0]                                                                      
      Artery, Inflammation, Chronic Active                          1 [4.0]                   1 [3.0]                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic Active             1 [2.0]                                                                      
   Testes                                             (50)         (50)         (50)         (50)                                   
      Mineralization                                                1 [1.0]      4 [1.0]     12 [1.1]                               
      Germinal Epithelium, Degeneration                             3 [2.0]      1 [1.0]      2 [1.0]                               
      Rete Testes, Cyst                                             1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Myeloid Cell, Hyperplasia                                                  1 [4.0]                                            
   Lymph Node                                         (1)          (1)          (3)          (5)                                    
      Deep Cervical, Hyperplasia, Lymphoid                                       1 [2.0]                                            
      Mediastinal, Hyperplasia, Lymphoid                            1 [3.0]      1 [2.0]                                            
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                     1 [3.0]                                                                      
      Mediastinal, Inflammation, Granulomatous                                                1 [3.0]                               
   Lymph Node, Mandibular                             (48)         (50)         (49)         (47)                                   
      Hyperplasia, Lymphoid                            5 [3.2]      1 [2.0]      6 [2.2]      5 [2.0]                               
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (48)                                   
      Hyperplasia, Lymphoid                            2 [3.0]      2 [3.0]                   2 [3.0]                               
      Infiltration Cellular, Histiocyte                1 [2.0]                                                                      
      Inflammation, Granulomatous                                                             1 [3.0]                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 [3.0]                                            
      Hematopoietic Cell Proliferation                11 [2.3]      7 [2.6]      9 [2.4]     14 [2.4]                               
      Lymphoid Follicle, Hyperplasia, Lymphoid        17 [2.1]     31 [2.5]     34 [2.0]     32 [2.2]                               
   Thymus                                             (46)         (48)         (46)         (47)                                   
      Atrophy                                         12 [2.3]      9 [2.8]      6 [2.8]      5 [3.4]                               
      Cyst                                            16 [1.6]     25 [1.4]     20 [1.5]     20 [1.3]                               
      Ectopic Parathyroid Gland                        2 [1.5]                                                                      
      Ectopic Thyroid                                                            1 [2.0]                                            
      Infiltration Cellular, Histiocyte                1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                               1                                     
      Inflammation, Granulomatous                      1 [3.0]                                                                      
      Mineralization                                                                          1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Spinal Cord                                        (1)          (1)          (1)                                                 
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Degeneration                                     1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 32 [1.1]     38 [1.1]     47 [1.1]     36 [1.0]                               
      Inflammation, Chronic Active                     1 [3.0]      2 [1.5]      1 [1.0]      1 [1.0]                               
      Metaplasia, Osseous                                                        1 [1.0]                                            
      Necrosis                                         1 [3.0]                                                                      
      Thrombosis                                                    1 [2.0]                                                         
      Alveolar Epithelium, Hyperplasia                 6 [1.7]      7 [2.6]      8 [1.9]      4 [3.3]                               
      Alveolus, Infiltration Cellular, Histiocyte      7 [2.4]      1 [2.0]      1 [2.0]      3 [1.7]                               
      Mediastinum, Inflammation, Suppurative                                     1 [3.0]                                            
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     2 [2.5]                   1 [1.0]      2 [1.0]                               
      Inflammation, Focal, Suppurative                                                        1 [1.0]                               
      Inflammation, Suppurative                                                  1 [2.0]                                            
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
        Active                                                                   2 [2.5]      1 [1.0]                               
      Olfactory Epithelium, Degeneration               1 [3.0]                                                                      
      Olfactory Epithelium, Metaplasia                              2 [1.0]      2 [1.0]     24 [1.2]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                                  1 [3.0]                                            
      Anterior Chamber, Iris, Inflammation,                                                                                         
        Suppurative                                                 1 [3.0]                                                         
      Cornea, Inflammation, Chronic Active                          1 [4.0]      2 [1.5]      1 [2.0]                               
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 [1.5]      3 [3.0]      3 [2.7]      2 [3.5]                               
      Infiltration Cellular, Lymphoid                 37 [1.0]     33 [1.0]     24 [1.0]     29 [1.0]                               
      Inflammation, Chronic Active                     1 [1.0]                   1 [1.0]                                            
      Mineralization                                                                          1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Infarct                                          1 [2.0]      1 [3.0]      1 [4.0]      4 [2.0]                               
      Infiltration Cellular, Lymphoid                 44 [1.1]     44 [1.1]     45 [1.0]     45 [1.3]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 88138-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/01/04    
Route: DOSED FEED                                                BENZOPHENONE                                     Time: 14:05:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 PPM        312 PPM      625 PPM      1250 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                  1 [1.0]      2 [2.0]                                            
      Metaplasia, Osseous                              4 [1.0]      2 [1.5]      1 [1.0]      8 [1.4]                               
      Mineralization                                  49 [1.0]     50 [1.0]     50 [1.0]     50 [1.0]                               
      Necrosis                                                                   1 [1.0]                                            
      Nephropathy                                     49 [1.2]     48 [1.4]     50 [1.7]     50 [3.0]                               
      Artery, Inflammation, Chronic Active             1 [2.0]      1 [2.0]                                                         
      Cortex, Cyst                                     4            8           12           22                                     
      Renal Tubule, Pigmentation                                                              1 [3.0]                               
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphoid                 24 [1.0]     24 [1.0]     32 [1.0]     23 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.