National Toxicology Program

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TDMS Study 96017-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 04/14/04       
EXPERIMENT: 96017 TEST: 05                                                                                     TIME: 09:21:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HERSCHELL, GILES                                                                                  CAS: 631-64-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 04/14/04       
EXPERIMENT: 96017 TEST: 05                                                                                     TIME: 09:21:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HERSCHELL, GILES                                                                                  CAS: 631-64-1        
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Pancreas                                                                           
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 04/14/04       
EXPERIMENT: 96017 TEST: 05                                                                                     TIME: 09:21:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HERSCHELL, GILES                                                                                  CAS: 631-64-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF   WATER DISINFECTION BYPRODUCTS (DIBROMOAC                                                                       
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Testes                                 Adenoma                                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Mesothelioma: Benign, Malignant, NOS                                                         
                                       Mesothelioma: Malignant                                                                      
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Clitoral/Preputial Gland               Adenoma                                                                                      
Mammary Gland                          Fibroadenoma                                                                                 
                                       Fibroma, Fibroadenoma or Adenoma                                                             
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Thyroid Gland: Follicular Cell         Adenoma                                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 1       
Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   6/50 (12%)   8/49 (16%)   6/50 (12%)  |1/49 (2%)    3/50 (6%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     7/42.66      6/42.27      8/39.97      6/41.42     |1/43.23      3/46.29      2/44.36      1/42.48      | 
|POLY-3 PERCENT (g) |     16.4%        14.2%        20.0%        14.5%       |2.3%         6.5%         4.5%         2.4%         | 
|TERMINAL (d)       |     6/34 (18%)   1/24 (4%)    5/30 (17%)   3/28 (11%)  |1/35 (3%)    2/39 (5%)    2/35 (6%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     711          618          560          624         |729 (T)      720          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.530      P=0.529      P=0.406      P=0.607     |P=0.441N     P=0.348      P=0.500      P=0.742      | 
|POLY 3             |     P=0.549N     P=0.507N     P=0.445      P=0.523N    |P=0.396N     P=0.330      P=0.509      P=0.757      | 
|POLY 1.5           |     P=0.535N     P=0.493N     P=0.460      P=0.505N    |P=0.391N     P=0.323      P=0.509      P=0.759      | 
|POLY 6             |     P=0.538      P=0.532N     P=0.430      P=0.547N    |P=0.404N     P=0.342      P=0.511      P=0.755      | 
|LOGISTIC REGRESSION|     P=0.541      P=0.544N     P=0.415      P=0.546N    |P=0.440N     P=0.358      P=0.500      P=0.742      | 
|COCH-ARM / FISHERS |     P=0.510N     P=0.484N     P=0.500      P=0.484N    |P=0.385N     P=0.316      P=0.508      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.601N     (e)          (e)          (e)         |P=0.481      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/49 (0%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/42.59      2/42.35      0/39.19      1/40.64     |0/43.23      0/46.25      0/44.36      0/42.48      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         0.0%         2.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          437          ---          651         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.633N     P=0.228      (e)          P=0.478     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.622N     P=0.236      (e)          P=0.491     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.614N     P=0.240      (e)          P=0.497     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.633N     P=0.227      (e)          P=0.482     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.582N     P=0.199      (e)          P=0.510     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.604N     P=0.253      (e)          P=0.505     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.316      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   7/50 (14%)   8/49 (16%)   8/50 (16%)  |1/49 (2%)    3/50 (6%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     7/42.66      7/43.05      8/39.97      8/41.71     |1/43.23      3/46.29      2/44.36      1/42.48      | 
|POLY-3 PERCENT (g) |     16.4%        16.3%        20.0%        19.2%       |2.3%         6.5%         4.5%         2.4%         | 
|TERMINAL (d)       |     6/34 (18%)   1/24 (4%)    5/30 (17%)   4/28 (14%)  |1/35 (3%)    2/39 (5%)    2/35 (6%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     711          437          560          624         |729 (T)      720          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.358      P=0.420      P=0.406      P=0.370     |P=0.441N     P=0.348      P=0.500      P=0.742      | 
|POLY 3             |     P=0.371      P=0.607N     P=0.445      P=0.481     |P=0.396N     P=0.330      P=0.509      P=0.757      | 
|POLY 1.5           |     P=0.387      P=0.597N     P=0.460      P=0.498     |P=0.391N     P=0.323      P=0.509      P=0.759      | 
|POLY 6             |     P=0.358      P=0.603      P=0.430      P=0.460     |P=0.404N     P=0.342      P=0.511      P=0.755      | 
|LOGISTIC REGRESSION|     P=0.381      P=0.610N     P=0.415      P=0.456     |P=0.440N     P=0.358      P=0.500      P=0.742      | 
|COCH-ARM / FISHERS |     P=0.416      P=0.597N     P=0.500      P=0.517     |P=0.385N     P=0.316      P=0.508      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.546      (e)          (e)          (e)         |P=0.481      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.13      0/41.42      2/40.20      0/40.35     |0/44.12      0/46.25      1/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         5.0%         0.0%        |0.0%         0.0%         2.3%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    1/35 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     433          ---          590          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.568N     P=0.496N     P=0.465      P=0.508N    |P=0.175      (e)          P=0.500      P=0.482      | 
|POLY 3             |     P=0.567N     P=0.513N     P=0.468      P=0.518N    |P=0.189      (e)          P=0.501      P=0.495      | 
|POLY 1.5           |     P=0.560N     P=0.506N     P=0.478      P=0.510N    |P=0.195      (e)          P=0.501      P=0.497      | 
|POLY 6             |     P=0.574N     P=0.523N     P=0.458      P=0.528N    |P=0.182      (e)          P=0.502      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.523N     P=0.651N     P=0.562      P=0.553N    |(e)          (e)          P=0.500      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.550N     P=0.500N     P=0.500      P=0.500N    |P=0.202      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.323N     (e)          (e)          (e)         |P=0.246      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   8/50 (16%)   4/50 (8%)   |8/50 (16%)   10/50 (20%)  5/48 (10%)   3/49 (6%)    | 
|POLY-3 RATE (b)    |     3/43.34      5/41.62      8/39.85      4/41.16     |8/44.44      10/46.55     5/42.36      3/41.95      | 
|POLY-3 PERCENT (g) |     6.9%         12.0%        20.1%        9.7%        |18.0%        21.5%        11.8%        7.2%         | 
|TERMINAL (d)       |     3/34 (9%)    4/24 (17%)   7/30 (23%)   2/28 (7%)   |7/35 (20%)   8/39 (21%)   5/33 (15%)   3/31 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      679          700          610         |641          682          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.401      P=0.198      P=0.065      P=0.415     |P=0.050N     P=0.505      P=0.309N     P=0.136N     | 
|POLY 3             |     P=0.403      P=0.333      P=0.072      P=0.472     |P=0.033N*    P=0.439      P=0.306N     P=0.116N     | 
|POLY 1.5           |     P=0.419      P=0.347      P=0.080      P=0.485     |P=0.029N*    P=0.423      P=0.303N     P=0.111N     | 
|POLY 6             |     P=0.386      P=0.311      P=0.064      P=0.455     |P=0.038N*    P=0.470      P=0.306N     P=0.123N     | 
|LOGISTIC REGRESSION|     P=0.376      P=0.265      P=0.059      P=0.473     |P=0.042N*    P=0.472      P=0.292N     P=0.126N     | 
|COCH-ARM / FISHERS |     P=0.442      P=0.357      P=0.100      P=0.500     |P=0.027N*    P=0.398      P=0.304N     P=0.106N     | 
|ORDER RESTRICTED   |     P=0.203      (e)          (e)          (e)         |P=0.074N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    6/50 (12%)   1/48 (2%)    5/49 (10%)   | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      0/39.73      0/40.35     |1/44.12      6/47.21      1/42.36      5/42.88      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         12.7%        2.4%         11.7%        | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |1/35 (3%)    4/39 (10%)   1/33 (3%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      392          729 (T)      580          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.281      P=0.079      P=0.749      P=0.093      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.335      P=0.068      P=0.752      P=0.094      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.339      P=0.063      P=0.752      P=0.095      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.332      P=0.075      P=0.753      P=0.093      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.355      P=0.050      P=0.749      P=0.099      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.343      P=0.056      P=0.742      P=0.098      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.068      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   8/50 (16%)   4/50 (8%)   |9/50 (18%)   15/50 (30%)  6/48 (13%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |     3/43.34      5/41.62      8/39.85      4/41.16     |9/44.44      15/47.51     6/42.36      8/42.88      | 
|POLY-3 PERCENT (g) |     6.9%         12.0%        20.1%        9.7%        |20.3%        31.6%        14.2%        18.7%        | 
|TERMINAL (d)       |     3/34 (9%)    4/24 (17%)   7/30 (23%)   2/28 (7%)   |8/35 (23%)   11/39 (28%)  6/33 (18%)   5/31 (16%)   | 
|FIRST INCIDENCE    |     729 (T)      679          700          610         |641          392          729 (T)      580          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.401      P=0.198      P=0.065      P=0.415     |P=0.222N     P=0.202      P=0.324N     P=0.585N     | 
|POLY 3             |     P=0.403      P=0.333      P=0.072      P=0.472     |P=0.143N     P=0.158      P=0.321N     P=0.533N     | 
|POLY 1.5           |     P=0.419      P=0.347      P=0.080      P=0.485     |P=0.135N     P=0.143      P=0.318N     P=0.526N     | 
|POLY 6             |     P=0.386      P=0.311      P=0.064      P=0.455     |P=0.155N     P=0.185      P=0.321N     P=0.539N     | 
|LOGISTIC REGRESSION|     P=0.376      P=0.265      P=0.059      P=0.473     |P=0.150N     P=0.134      P=0.304N     P=0.548N     | 
|COCH-ARM / FISHERS |     P=0.442      P=0.357      P=0.100      P=0.500     |P=0.126N     P=0.121      P=0.318N     P=0.518N     | 
|ORDER RESTRICTED   |     P=0.203      (e)          (e)          (e)         |P=0.211N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/48 (10%)   3/50 (6%)    4/48 (8%)    1/50 (2%)   |0/47 (0%)    0/49 (0%)    0/49 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     5/42.17      3/41.64      4/39.16      1/41.00     |0/41.84      0/45.91      0/43.63      0/41.81      | 
|POLY-3 PERCENT (g) |     11.9%        7.2%         10.2%        2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/34 (12%)   1/24 (4%)    3/30 (10%)   0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     682          679          560          512         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.143N     P=0.522N     P=0.573N     P=0.150N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.130N     P=0.363N     P=0.547N     P=0.107N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.125N     P=0.346N     P=0.533N     P=0.099N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.136N     P=0.392N     P=0.562N     P=0.119N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.129N     P=0.401N     P=0.549N     P=0.097N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.118N     P=0.335N     P=0.500N     P=0.093N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.082N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/48 (10%)   3/50 (6%)    5/48 (10%)   1/50 (2%)   |0/47 (0%)    0/49 (0%)    0/49 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     5/42.17      3/41.64      5/39.35      1/41.00     |0/41.84      0/45.91      0/43.63      0/41.81      | 
|POLY-3 PERCENT (g) |     11.9%        7.2%         12.7%        2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/34 (12%)   1/24 (4%)    3/30 (10%)   0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     682          679          560          512         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.176N     P=0.522N     P=0.552      P=0.150N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.157N     P=0.363N     P=0.587      P=0.107N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.151N     P=0.346N     P=0.599      P=0.099N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.165N     P=0.392N     P=0.574      P=0.119N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.155N     P=0.401N     P=0.586      P=0.097N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.142N     P=0.335N     P=0.630N     P=0.093N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.092N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.34      1/41.42      2/39.73      1/40.64     |2/44.12      0/46.25      0/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         2.4%         5.0%         2.5%        |4.5%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    2/30 (7%)    0/28 (0%)   |2/35 (6%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      651         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541      P=0.682      P=0.456      P=0.724     |P=0.590N     P=0.215N     P=0.238N     P=0.531N     | 
|POLY 3             |     P=0.539      P=0.751      P=0.470      P=0.746     |P=0.563N     P=0.227N     P=0.236N     P=0.509N     | 
|POLY 1.5           |     P=0.548      P=0.757      P=0.479      P=0.753     |P=0.558N     P=0.231N     P=0.236N     P=0.505N     | 
|POLY 6             |     P=0.529      P=0.741      P=0.459      P=0.737     |P=0.573N     P=0.220N     P=0.234N     P=0.515N     | 
|LOGISTIC REGRESSION|     P=0.531      P=0.682      P=0.456      P=0.756     |P=0.590N     (e)          (e)          P=0.531N     | 
|COCH-ARM / FISHERS |     P=0.561      P=0.753N     P=0.500      P=0.753N    |P=0.550N     P=0.247N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.551      (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.34      1/41.42      3/39.73      1/40.64     |2/44.12      0/46.25      1/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         2.4%         7.6%         2.5%        |4.5%         0.0%         2.3%         4.7%         | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    3/30 (10%)   0/28 (0%)   |2/35 (6%)    0/39 (0%)    1/35 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      651         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488      P=0.682      P=0.261      P=0.724     |P=0.313      P=0.215N     P=0.500N     P=0.663      | 
|POLY 3             |     P=0.485      P=0.751      P=0.274      P=0.746     |P=0.339      P=0.227N     P=0.498N     P=0.684      | 
|POLY 1.5           |     P=0.496      P=0.757      P=0.284      P=0.753     |P=0.349      P=0.231N     P=0.498N     P=0.689      | 
|POLY 6             |     P=0.473      P=0.741      P=0.263      P=0.737     |P=0.325      P=0.220N     P=0.496N     P=0.679      | 
|LOGISTIC REGRESSION|     P=0.474      P=0.682      P=0.261      P=0.756     |P=0.313      (e)          P=0.500N     P=0.663      | 
|COCH-ARM / FISHERS |     P=0.510      P=0.753N     P=0.309      P=0.753N    |P=0.363      P=0.247N     P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.405      (e)          (e)          (e)         |P=0.394      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.34      1/41.42      3/39.73      1/40.64     |2/44.12      0/46.25      1/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         2.4%         7.6%         2.5%        |4.5%         0.0%         2.3%         4.7%         | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    3/30 (10%)   0/28 (0%)   |2/35 (6%)    0/39 (0%)    1/35 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      651         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488      P=0.682      P=0.261      P=0.724     |P=0.313      P=0.215N     P=0.500N     P=0.663      | 
|POLY 3             |     P=0.485      P=0.751      P=0.274      P=0.746     |P=0.339      P=0.227N     P=0.498N     P=0.684      | 
|POLY 1.5           |     P=0.496      P=0.757      P=0.284      P=0.753     |P=0.349      P=0.231N     P=0.498N     P=0.689      | 
|POLY 6             |     P=0.473      P=0.741      P=0.263      P=0.737     |P=0.325      P=0.220N     P=0.496N     P=0.679      | 
|LOGISTIC REGRESSION|     P=0.474      P=0.682      P=0.261      P=0.756     |P=0.313      (e)          P=0.500N     P=0.663      | 
|COCH-ARM / FISHERS |     P=0.510      P=0.753N     P=0.309      P=0.753N    |P=0.363      P=0.247N     P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.405      (e)          (e)          (e)         |P=0.394      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    4/50 (8%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/43.52      0/41.42      4/39.73      2/40.46     |1/44.12      1/46.25      2/44.36      3/42.95      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         10.1%        4.9%        |2.3%         2.2%         4.5%         7.0%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    4/30 (13%)   1/28 (4%)   |1/35 (3%)    1/39 (3%)    2/35 (6%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     682          ---          729 (T)      701         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.254      P=0.298N     P=0.279      P=0.616     |P=0.112      P=0.738N     P=0.500      P=0.273      | 
|POLY 3             |     P=0.257      P=0.248N     P=0.295      P=0.668     |P=0.137      P=0.750N     P=0.502      P=0.295      | 
|POLY 1.5           |     P=0.266      P=0.242N     P=0.309      P=0.680     |P=0.143      P=0.754N     P=0.502      P=0.300      | 
|POLY 6             |     P=0.247      P=0.259N     P=0.280      P=0.651     |P=0.129      P=0.743N     P=0.504      P=0.289      | 
|LOGISTIC REGRESSION|     P=0.241      P=0.249N     P=0.276      P=0.660     |P=0.112      P=0.738N     P=0.500      P=0.273      | 
|COCH-ARM / FISHERS |     P=0.281      P=0.247N     P=0.339      P=0.691N    |P=0.150      P=0.753N     P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.211      (e)          (e)          (e)         |P=0.203      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      1/41.71      1/39.73      0/40.35     |1/44.47      2/46.25      0/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.5%         0.0%        |2.3%         4.3%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    2/39 (5%)    0/35 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          651          729 (T)      ---         |632          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.537N     P=0.490      P=0.475      (e)         |P=0.492      P=0.533      P=0.505N     P=0.474      | 
|POLY 3             |     P=0.537N     P=0.492      P=0.483      (e)         |P=0.527      P=0.514      P=0.500N     P=0.488      | 
|POLY 1.5           |     P=0.528N     P=0.497      P=0.488      (e)         |P=0.532      P=0.508      P=0.500N     P=0.493      | 
|POLY 6             |     P=0.549N     P=0.485      P=0.476      (e)         |P=0.520      P=0.523      P=0.500N     P=0.480      | 
|LOGISTIC REGRESSION|     P=0.526N     P=0.500      P=0.475      (e)         |P=0.523      P=0.500      P=0.517N     P=0.496      | 
|COCH-ARM / FISHERS |     P=0.518N     P=0.500      P=0.500      (e)         |P=0.539      P=0.500      P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.391      (e)          (e)          (e)         |P=0.394      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    5/50 (10%)   2/50 (4%)   |2/50 (4%)    3/50 (6%)    2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/43.52      1/41.71      5/39.73      2/40.46     |2/44.47      3/46.25      2/44.36      5/42.95      | 
|POLY-3 PERCENT (g) |     4.6%         2.4%         12.6%        4.9%        |4.5%         6.5%         4.5%         11.6%        | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    5/30 (17%)   1/28 (4%)   |1/35 (3%)    3/39 (8%)    2/35 (6%)    5/32 (16%)   | 
|FIRST INCIDENCE    |     682          651          729 (T)      701         |632          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.565N     P=0.167      P=0.616     |P=0.127      P=0.545      P=0.691      P=0.185      | 
|POLY 3             |     P=0.331      P=0.515N     P=0.180      P=0.668     |P=0.161      P=0.518      P=0.693      P=0.201      | 
|POLY 1.5           |     P=0.346      P=0.506N     P=0.192      P=0.680     |P=0.169      P=0.511      P=0.693N     P=0.209      | 
|POLY 6             |     P=0.313      P=0.530N     P=0.166      P=0.651     |P=0.151      P=0.530      P=0.694      P=0.192      | 
|LOGISTIC REGRESSION|     P=0.323      P=0.503N     P=0.163      P=0.660     |P=0.139      P=0.515      P=0.693N     P=0.198      | 
|COCH-ARM / FISHERS |     P=0.366      P=0.500N     P=0.218      P=0.691N    |P=0.178      P=0.500      P=0.691N     P=0.218      | 
|ORDER RESTRICTED   |     P=0.247      (e)          (e)          (e)         |P=0.145      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.34      0/41.42      1/39.73      1/40.35     |3/44.12      1/46.25      2/44.69      1/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.5%         2.5%        |6.8%         2.2%         4.5%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    1/30 (3%)    1/28 (4%)   |3/35 (9%)    1/39 (3%)    1/35 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |729 (T)      729 (T)      640          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.438      P=0.569N     P=0.734      P=0.718     |P=0.399N     P=0.267N     P=0.498N     P=0.337N     | 
|POLY 3             |     P=0.436      P=0.509N     P=0.741      P=0.745     |P=0.371N     P=0.289N     P=0.494N     P=0.315N     | 
|POLY 1.5           |     P=0.441      P=0.504N     P=0.747      P=0.752     |P=0.361N     P=0.295N     P=0.496N     P=0.310N     | 
|POLY 6             |     P=0.430      P=0.518N     P=0.734      P=0.734     |P=0.389N     P=0.277N     P=0.489N     P=0.320N     | 
|LOGISTIC REGRESSION|     P=0.438      (e)          P=0.734      P=0.718     |P=0.375N     P=0.267N     P=0.497N     P=0.337N     | 
|COCH-ARM / FISHERS |     P=0.450      P=0.500N     P=0.753N     P=0.753N    |P=0.347N     P=0.309N     P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.513      (e)          (e)          (e)         |P=0.230N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.34      0/41.42      1/39.73      2/40.35     |3/44.12      2/46.25      2/44.69      1/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.5%         5.0%        |6.8%         4.3%         4.5%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    1/30 (3%)    2/28 (7%)   |3/35 (9%)    2/39 (5%)    1/35 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |729 (T)      729 (T)      640          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.180      P=0.569N     P=0.734      P=0.432     |P=0.299N     P=0.450N     P=0.498N     P=0.337N     | 
|POLY 3             |     P=0.180      P=0.509N     P=0.741      P=0.475     |P=0.271N     P=0.479N     P=0.494N     P=0.315N     | 
|POLY 1.5           |     P=0.184      P=0.504N     P=0.747      P=0.487     |P=0.263N     P=0.487N     P=0.496N     P=0.310N     | 
|POLY 6             |     P=0.176      P=0.518N     P=0.734      P=0.459     |P=0.284N     P=0.463N     P=0.489N     P=0.320N     | 
|LOGISTIC REGRESSION|     P=0.180      (e)          P=0.734      P=0.432     |P=0.279N     P=0.450N     P=0.497N     P=0.337N     | 
|COCH-ARM / FISHERS |     P=0.191      P=0.500N     P=0.753N     P=0.500     |P=0.251N     P=0.500N     P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.204      (e)          (e)          (e)         |P=0.255N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   4/50 (8%)    5/50 (10%)  |32/50 (64%)  33/50 (66%)  39/50 (78%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     4/43.34      5/41.61      4/39.73      5/40.35     |32/45.65     33/47.34     39/46.55     36/44.88     | 
|POLY-3 PERCENT (g) |     9.2%         12.0%        10.1%        12.4%       |70.1%        69.7%        83.8%        80.2%        | 
|TERMINAL (d)       |     4/34 (12%)   3/24 (13%)   4/30 (13%)   5/28 (18%)  |27/35 (77%)  28/39 (72%)  31/35 (89%)  30/32 (94%)  | 
|FIRST INCIDENCE    |     729 (T)      701          729 (T)      729 (T)     |602          521          441          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.460      P=0.310      P=0.575      P=0.377     |P=0.016 *    P=0.383N     P=0.113      P=0.095      | 
|POLY 3             |     P=0.447      P=0.474      P=0.595      P=0.455     |P=0.061      P=0.576N     P=0.079      P=0.175      | 
|POLY 1.5           |     P=0.466      P=0.490      P=0.611      P=0.476     |P=0.094      P=0.568      P=0.087      P=0.212      | 
|POLY 6             |     P=0.423      P=0.449      P=0.578      P=0.426     |P=0.030 *    P=0.510N     P=0.078      P=0.131      | 
|LOGISTIC REGRESSION|     P=0.426      P=0.387      P=0.575      P=0.377     |P=0.048 *    P=0.511N     P=0.072      P=0.145      | 
|COCH-ARM / FISHERS |     P=0.494      P=0.500      P=0.643N     P=0.500     |P=0.156      P=0.500      P=0.093      P=0.260      | 
|ORDER RESTRICTED   |     P=0.504      (e)          (e)          (e)         |P=0.118      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   4/50 (8%)    6/50 (12%)  |32/50 (64%)  33/50 (66%)  39/50 (78%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     4/43.34      5/41.61      4/39.73      6/40.35     |32/45.65     33/47.34     39/46.55     36/44.88     | 
|POLY-3 PERCENT (g) |     9.2%         12.0%        10.1%        14.9%       |70.1%        69.7%        83.8%        80.2%        | 
|TERMINAL (d)       |     4/34 (12%)   3/24 (13%)   4/30 (13%)   6/28 (21%)  |27/35 (77%)  28/39 (72%)  31/35 (89%)  30/32 (94%)  | 
|FIRST INCIDENCE    |     729 (T)      701          729 (T)      729 (T)     |602          521          441          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.317      P=0.310      P=0.575      P=0.249     |P=0.016 *    P=0.383N     P=0.113      P=0.095      | 
|POLY 3             |     P=0.307      P=0.474      P=0.595      P=0.324     |P=0.061      P=0.576N     P=0.079      P=0.175      | 
|POLY 1.5           |     P=0.326      P=0.490      P=0.611      P=0.346     |P=0.094      P=0.568      P=0.087      P=0.212      | 
|POLY 6             |     P=0.286      P=0.449      P=0.578      P=0.296     |P=0.030 *    P=0.510N     P=0.078      P=0.131      | 
|LOGISTIC REGRESSION|     P=0.285      P=0.387      P=0.575      P=0.249     |P=0.048 *    P=0.511N     P=0.072      P=0.145      | 
|COCH-ARM / FISHERS |     P=0.352      P=0.500      P=0.643N     P=0.370     |P=0.156      P=0.500      P=0.093      P=0.260      | 
|ORDER RESTRICTED   |     P=0.330      (e)          (e)          (e)         |P=0.118      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   5/50 (10%)   7/50 (14%)  |32/50 (64%)  34/50 (68%)  40/50 (80%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     5/43.34      5/41.61      5/39.73      7/40.35     |32/45.65     34/47.34     40/46.87     36/44.88     | 
|POLY-3 PERCENT (g) |     11.5%        12.0%        12.6%        17.4%       |70.1%        71.8%        85.3%        80.2%        | 
|TERMINAL (d)       |     5/34 (15%)   3/24 (13%)   5/30 (17%)   7/28 (25%)  |27/35 (77%)  29/39 (74%)  31/35 (89%)  30/32 (94%)  | 
|FIRST INCIDENCE    |     729 (T)      701          729 (T)      729 (T)     |602          521          441          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256      P=0.422      P=0.551      P=0.244     |P=0.020 *    P=0.457N     P=0.083      P=0.095      | 
|POLY 3             |     P=0.249      P=0.605      P=0.575      P=0.328     |P=0.073      P=0.519      P=0.052      P=0.175      | 
|POLY 1.5           |     P=0.267      P=0.620      P=0.593      P=0.352     |P=0.109      P=0.480      P=0.055      P=0.212      | 
|POLY 6             |     P=0.228      P=0.580      P=0.555      P=0.296     |P=0.038 *    P=0.590      P=0.056      P=0.131      | 
|LOGISTIC REGRESSION|     P=0.225      P=0.511      P=0.551      P=0.244     |P=0.058      P=0.586      P=0.042 *    P=0.145      | 
|COCH-ARM / FISHERS |     P=0.293      P=0.630N     P=0.630N     P=0.380     |P=0.175      P=0.417      P=0.059      P=0.260      | 
|ORDER RESTRICTED   |     P=0.343      (e)          (e)          (e)         |P=0.098      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Papilloma Squamous or Papilloma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      0/39.73      0/40.35     |0/44.12      1/46.25      0/44.36      2/43.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    1/39 (3%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.154      P=0.522      (e)          P=0.230      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.175      P=0.509      (e)          P=0.232      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.177      P=0.506      (e)          P=0.235      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.173      P=0.516      (e)          P=0.230      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.170      P=0.522      (e)          P=0.235      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.179      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.072      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      1/40.15      0/40.35     |0/44.12      1/46.25      0/44.36      2/43.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.5%         0.0%        |0.0%         2.2%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    1/39 (3%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          607          ---         |---          729 (T)      ---          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.619      (e)          P=0.465      (e)         |P=0.154      P=0.522      (e)          P=0.230      | 
|POLY 3             |     P=0.614      (e)          P=0.485      (e)         |P=0.175      P=0.509      (e)          P=0.232      | 
|POLY 1.5           |     P=0.624      (e)          P=0.489      (e)         |P=0.177      P=0.506      (e)          P=0.235      | 
|POLY 6             |     P=0.601      (e)          P=0.480      (e)         |P=0.173      P=0.516      (e)          P=0.230      | 
|LOGISTIC REGRESSION|     P=0.648      (e)          P=0.526      (e)         |P=0.170      P=0.522      (e)          P=0.235      | 
|COCH-ARM / FISHERS |     P=0.634      (e)          P=0.500      (e)         |P=0.179      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.367      (e)          (e)          (e)         |P=0.072      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/50 (4%)    2/48 (4%)    1/49 (2%)   |0/47 (0%)    0/50 (0%)    0/49 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/41.99      2/41.81      2/38.61      1/40.00     |0/41.84      0/46.25      0/43.63      1/41.81      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         5.2%         2.5%        |0.0%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    2/30 (7%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          618          729 (T)      729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.521      P=0.197      P=0.211      P=0.461     |P=0.165      (e)          (e)          P=0.482      | 
|POLY 3             |     P=0.506      P=0.236      P=0.219      P=0.490     |P=0.177      (e)          (e)          P=0.500      | 
|POLY 1.5           |     P=0.522      P=0.242      P=0.224      P=0.497     |P=0.180      (e)          (e)          P=0.502      | 
|POLY 6             |     P=0.484      P=0.226      P=0.212      P=0.480     |P=0.174      (e)          (e)          P=0.497      | 
|LOGISTIC REGRESSION|     P=0.517      P=0.248      P=0.211      P=0.461     |(e)          (e)          (e)          P=0.482      | 
|COCH-ARM / FISHERS |     P=0.538      P=0.258      P=0.247      P=0.505     |P=0.182      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.216      (e)          (e)          (e)         |P=0.120      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  21/49 (43%)  17/49 (35%)  8/50 (16%)  |26/50 (52%)  30/50 (60%)  28/50 (56%)  22/49 (45%)  | 
|POLY-3 RATE (b)    |     23/45.06     21/42.91     17/41.48     8/41.56     |26/46.51     30/47.54     28/45.71     22/44.19     | 
|POLY-3 PERCENT (g) |     51.0%        48.9%        41.0%        19.3%       |55.9%        63.1%        61.3%        49.8%        | 
|TERMINAL (d)       |     16/34 (47%)  13/24 (54%)  11/30 (37%)  5/28 (18%)  |20/35 (57%)  24/39 (62%)  22/35 (63%)  16/32 (50%)  | 
|FIRST INCIDENCE    |     591          602          560          512         |519          509          622          602          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002N**   P=0.300      P=0.330N     P=0.011N*   |P=0.362N     P=0.496      P=0.435      P=0.411N     | 
|POLY 3             |     P<0.001N**   P=0.507N     P=0.232N     P<0.001N**  |P=0.197N     P=0.306      P=0.376      P=0.352N     | 
|POLY 1.5           |     P<0.001N**   P=0.474N     P=0.215N     P<0.001N**  |P=0.173N     P=0.295      P=0.399      P=0.332N     | 
|POLY 6             |     P<0.001N**   P=0.560N     P=0.253N     P=0.002N**  |P=0.232N     P=0.338      P=0.365      P=0.374N     | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.528N     P=0.245N     P=0.002N**  |P=0.192N     P=0.326      P=0.425      P=0.325N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.455N     P=0.173N     P<0.001N**  |P=0.145N     P=0.273      P=0.421      P=0.307N     | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.249N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  21/49 (43%)  17/49 (35%)  8/50 (16%)  |26/50 (52%)  31/50 (62%)  28/50 (56%)  23/49 (47%)  | 
|POLY-3 RATE (b)    |     23/45.06     21/42.91     17/41.48     8/41.56     |26/46.51     31/47.54     28/45.71     23/44.52     | 
|POLY-3 PERCENT (g) |     51.0%        48.9%        41.0%        19.3%       |55.9%        65.2%        61.3%        51.7%        | 
|TERMINAL (d)       |     16/34 (47%)  13/24 (54%)  11/30 (37%)  5/28 (18%)  |20/35 (57%)  25/39 (64%)  22/35 (63%)  16/32 (50%)  | 
|FIRST INCIDENCE    |     591          602          560          512         |519          509          622          602          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002N**   P=0.300      P=0.330N     P=0.011N*   |P=0.401N     P=0.427      P=0.435      P=0.485N     | 
|POLY 3             |     P<0.001N**   P=0.507N     P=0.232N     P<0.001N**  |P=0.214N     P=0.235      P=0.376      P=0.421N     | 
|POLY 1.5           |     P<0.001N**   P=0.474N     P=0.215N     P<0.001N**  |P=0.194N     P=0.226      P=0.399      P=0.404N     | 
|POLY 6             |     P<0.001N**   P=0.560N     P=0.253N     P=0.002N**  |P=0.241N     P=0.263      P=0.365      P=0.434N     | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.528N     P=0.245N     P=0.002N**  |P=0.219N     P=0.258      P=0.425      P=0.401N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.455N     P=0.173N     P<0.001N**  |P=0.168N     P=0.210      P=0.421      P=0.381N     | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.293N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.34      1/41.42      0/39.73      0/40.35     |0/44.12      0/46.25      0/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     4.6%         2.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     2/34 (6%)    1/24 (4%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.111N     P=0.621N     P=0.266N     P=0.282N    |P=0.165      (e)          (e)          P=0.482      | 
|POLY 3             |     P=0.110N     P=0.516N     P=0.257N     P=0.253N    |P=0.178      (e)          (e)          P=0.495      | 
|POLY 1.5           |     P=0.110N     P=0.507N     P=0.250N     P=0.246N    |P=0.181      (e)          (e)          P=0.497      | 
|POLY 6             |     P=0.110N     P=0.531N     P=0.264N     P=0.264N    |P=0.175      (e)          (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.111N     P=0.621N     (e)          (e)         |(e)          (e)          (e)          P=0.482      | 
|COCH-ARM / FISHERS |     P=0.107N     P=0.500N     P=0.247N     P=0.247N    |P=0.184      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.085N     (e)          (e)          (e)         |P=0.115      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    2/50 (4%)    5/50 (10%)  |1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     7/43.70      3/41.56      2/39.73      5/40.66     |1/44.12      1/46.25      1/44.36      2/43.13      | 
|POLY-3 PERCENT (g) |     16.0%        7.2%         5.0%         12.3%       |2.3%         2.2%         2.3%         4.6%         | 
|TERMINAL (d)       |     6/34 (18%)   2/24 (8%)    2/30 (7%)    3/28 (11%)  |1/35 (3%)    1/39 (3%)    1/35 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     629          693          729 (T)      651         |729 (T)      729 (T)      729 (T)      682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490N     P=0.305N     P=0.116N     P=0.508N    |P=0.291      P=0.738N     P=0.762      P=0.469      | 
|POLY 3             |     P=0.481N     P=0.177N     P=0.102N     P=0.430N    |P=0.327      P=0.750N     P=0.760N     P=0.492      | 
|POLY 1.5           |     P=0.472N     P=0.166N     P=0.094N     P=0.406N    |P=0.334      P=0.754N     P=0.759N     P=0.496      | 
|POLY 6             |     P=0.488N     P=0.197N     P=0.113N     P=0.463N    |P=0.317      P=0.743N     P=0.758N     P=0.488      | 
|LOGISTIC REGRESSION|     P=0.517N     P=0.199N     P=0.111N     P=0.461N    |P=0.309      P=0.738N     P=0.762      P=0.486      | 
|COCH-ARM / FISHERS |     P=0.453N     P=0.159N     P=0.080N     P=0.380N    |P=0.342      P=0.753N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.179N     (e)          (e)          (e)         |P=0.397      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/44.85      4/42.22      3/39.84      1/40.35     |1/44.12      0/46.25      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     11.2%        9.5%         7.5%         2.5%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    0/24 (0%)    2/30 (7%)    1/28 (4%)   |1/35 (3%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     516          651          701          729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.090N     P=0.589N     P=0.422N     P=0.146N    |P=0.386N     P=0.478N     P=0.500N     P=0.518N     | 
|POLY 3             |     P=0.086N     P=0.538N     P=0.423N     P=0.127N    |P=0.372N     P=0.491N     P=0.499N     P=0.505N     | 
|POLY 1.5           |     P=0.079N     P=0.518N     P=0.400N     P=0.115N    |P=0.370N     P=0.494N     P=0.499N     P=0.503N     | 
|POLY 6             |     P=0.097N     P=0.566N     P=0.449N     P=0.145N    |P=0.379N     P=0.484N     P=0.498N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.070N     P=0.497N     P=0.353N     P=0.095N    |P=0.386N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.069N     P=0.500N     P=0.357N     P=0.102N    |P=0.366N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.101N     (e)          (e)          (e)         |P=0.125N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   6/50 (12%)   4/50 (8%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/44.85      6/42.61      6/40.67      4/41.06     |1/44.12      0/46.25      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     13.4%        14.1%        14.8%        9.7%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/34 (9%)    1/24 (4%)    4/30 (13%)   2/28 (7%)   |1/35 (3%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     516          618          402          571         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.349N     P=0.496      P=0.542      P=0.473N    |P=0.386N     P=0.478N     P=0.500N     P=0.518N     | 
|POLY 3             |     P=0.346N     P=0.585      P=0.551      P=0.426N    |P=0.372N     P=0.491N     P=0.499N     P=0.505N     | 
|POLY 1.5           |     P=0.324N     P=0.604      P=0.575      P=0.400N    |P=0.370N     P=0.494N     P=0.499N     P=0.503N     | 
|POLY 6             |     P=0.374N     P=0.558      P=0.522      P=0.459N    |P=0.379N     P=0.484N     P=0.498N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.290N     P=0.616N     P=0.610N     P=0.355N    |P=0.386N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.293N     P=0.620N     P=0.620N     P=0.370N    |P=0.366N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.437N     (e)          (e)          (e)         |P=0.125N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.34      3/42.10      3/40.56      2/40.54     |0/44.12      0/46.25      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         7.1%         7.4%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    2/30 (7%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          618          402          679         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.363      P=0.099      P=0.107      P=0.195     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.357      P=0.113      P=0.107      P=0.222     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.374      P=0.117      P=0.111      P=0.229     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.335      P=0.107      P=0.102      P=0.213     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.401      P=0.121      P=0.134      P=0.219     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.394      P=0.121      P=0.121      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.34      3/42.10      3/40.56      3/41.06     |0/44.12      0/46.25      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         7.1%         7.4%         7.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    2/30 (7%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      618          402          571         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.307      P=0.240      P=0.272      P=0.249     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.309      P=0.294      P=0.281      P=0.286     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.321      P=0.301      P=0.289      P=0.295     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.295      P=0.283      P=0.272      P=0.274     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.345      P=0.304      P=0.318      P=0.303     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.337      P=0.309      P=0.309      P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.260      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.34      1/41.56      1/39.73      2/40.64     |0/44.12      0/46.25      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     6.9%         2.4%         2.5%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/34 (9%)    0/24 (0%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      693          729 (T)      651         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.562N     P=0.417N     P=0.350N     P=0.582N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.548N     P=0.320N     P=0.337N     P=0.529N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.544N     P=0.311N     P=0.327N     P=0.516N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.551N     P=0.335N     P=0.348N     P=0.547N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.570N     P=0.354N     P=0.350N     P=0.553N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.533N     P=0.309N     P=0.309N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.322N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    3/50 (6%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.70      1/41.42      2/39.73      3/40.38     |1/44.12      1/46.25      1/44.36      1/43.13      | 
|POLY-3 PERCENT (g) |     4.6%         2.4%         5.0%         7.4%        |2.3%         2.2%         2.3%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    2/30 (7%)    2/28 (7%)   |1/35 (3%)    1/39 (3%)    1/35 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          729 (T)      729 (T)      723         |729 (T)      729 (T)      729 (T)      682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.249      P=0.589N     P=0.640      P=0.425     |P=0.578      P=0.738N     P=0.762      P=0.741      | 
|POLY 3             |     P=0.244      P=0.519N     P=0.660      P=0.464     |P=0.605      P=0.750N     P=0.760N     P=0.756      | 
|POLY 1.5           |     P=0.253      P=0.508N     P=0.671      P=0.481     |P=0.612      P=0.754N     P=0.759N     P=0.758      | 
|POLY 6             |     P=0.234      P=0.536N     P=0.646      P=0.441     |P=0.594      P=0.743N     P=0.758N     P=0.753      | 
|LOGISTIC REGRESSION|     P=0.230      P=0.509N     P=0.665      P=0.458     |P=0.600      P=0.738N     P=0.762      P=0.758      | 
|COCH-ARM / FISHERS |     P=0.266      P=0.500N     P=0.691N     P=0.500     |P=0.623      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.319      (e)          (e)          (e)         |P=0.734      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    2/50 (4%)    5/50 (10%)  |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/43.70      2/41.56      2/39.73      5/40.66     |1/44.12      1/46.25      1/44.36      1/43.13      | 
|POLY-3 PERCENT (g) |     13.7%        4.8%         5.0%         12.3%       |2.3%         2.2%         2.3%         2.3%         | 
|TERMINAL (d)       |     5/34 (15%)   1/24 (4%)    2/30 (7%)    3/28 (11%)  |1/35 (3%)    1/39 (3%)    1/35 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          693          729 (T)      651         |729 (T)      729 (T)      729 (T)      682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.455      P=0.246N     P=0.182N     P=0.620N    |P=0.578      P=0.738N     P=0.762      P=0.741      | 
|POLY 3             |     P=0.463      P=0.148N     P=0.165N     P=0.551N    |P=0.605      P=0.750N     P=0.760N     P=0.756      | 
|POLY 1.5           |     P=0.472      P=0.139N     P=0.154N     P=0.527N    |P=0.612      P=0.754N     P=0.759N     P=0.758      | 
|POLY 6             |     P=0.456      P=0.164N     P=0.178N     P=0.582N    |P=0.594      P=0.743N     P=0.758N     P=0.753      | 
|LOGISTIC REGRESSION|     P=0.433      P=0.160N     P=0.173N     P=0.577N    |P=0.600      P=0.738N     P=0.762      P=0.758      | 
|COCH-ARM / FISHERS |     P=0.490      P=0.134N     P=0.134N     P=0.500N    |P=0.623      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |P=0.734      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/50 (4%)    5/50 (10%)  |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/43.70      2/41.56      2/39.73      5/40.66     |1/44.12      1/46.25      1/44.36      1/43.13      | 
|POLY-3 PERCENT (g) |     11.4%        4.8%         5.0%         12.3%       |2.3%         2.2%         2.3%         2.3%         | 
|TERMINAL (d)       |     4/34 (12%)   1/24 (4%)    2/30 (7%)    3/28 (11%)  |1/35 (3%)    1/39 (3%)    1/35 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          693          729 (T)      651         |729 (T)      729 (T)      729 (T)      682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.353      P=0.343N     P=0.275N     P=0.517     |P=0.578      P=0.738N     P=0.762      P=0.741      | 
|POLY 3             |     P=0.358      P=0.236N     P=0.256N     P=0.585     |P=0.605      P=0.750N     P=0.760N     P=0.756      | 
|POLY 1.5           |     P=0.367      P=0.225N     P=0.242N     P=0.606     |P=0.612      P=0.754N     P=0.759N     P=0.758      | 
|POLY 6             |     P=0.349      P=0.256N     P=0.272N     P=0.556     |P=0.594      P=0.743N     P=0.758N     P=0.753      | 
|LOGISTIC REGRESSION|     P=0.333      P=0.244N     P=0.263N     P=0.566     |P=0.600      P=0.738N     P=0.762      P=0.758      | 
|COCH-ARM / FISHERS |     P=0.385      P=0.218N     P=0.218N     P=0.630N    |P=0.623      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.314      (e)          (e)          (e)         |P=0.734      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  46/50 (92%)  41/49 (84%)  46/50 (92%) |                                                    | 
|POLY-3 RATE (b)    |     41/45.62     46/48.00     41/44.36     46/47.61    |                                                    | 
|POLY-3 PERCENT (g) |     89.9%        95.8%        92.4%        96.6%       |                                                    | 
|TERMINAL (d)       |     33/34 (97%)  24/24 (100%) 28/30 (93%)  27/28 (96%) |                                                    | 
|FIRST INCIDENCE    |     530          437          437          423         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.199      P=0.003 **   P=0.194      P=0.017 *   |                                                    | 
|POLY 3             |     P=0.228      P=0.194      P=0.475      P=0.149     |                                                    | 
|POLY 1.5           |     P=0.210      P=0.166      P=0.442      P=0.121     |                                                    | 
|POLY 6             |     P=0.330      P=0.227      P=0.560      P=0.240     |                                                    | 
|LOGISTIC REGRESSION|     P=0.084      P=0.055      P=0.191      P=0.023 *   |                                                    | 
|COCH-ARM / FISHERS |     P=0.259      P=0.117      P=0.518      P=0.117     |                                                    | 
|ORDER RESTRICTED   |     P=0.086      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   5/49 (10%)   7/50 (14%)  |6/50 (12%)   11/50 (22%)  5/50 (10%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     6/43.34      5/42.84      5/39.30      7/40.35     |6/44.58      11/46.25     5/44.36      5/43.29      | 
|POLY-3 PERCENT (g) |     13.8%        11.7%        12.7%        17.4%       |13.5%        23.8%        11.3%        11.6%        | 
|TERMINAL (d)       |     6/34 (18%)   2/24 (8%)    4/30 (13%)   7/28 (25%)  |5/35 (14%)   11/39 (28%)  5/35 (14%)   2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      471          701          729 (T)     |595          729 (T)      729 (T)      602          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.341      P=0.563      P=0.590N     P=0.348     |P=0.200N     P=0.197      P=0.503N     P=0.542N     | 
|POLY 3             |     P=0.314      P=0.508N     P=0.569N     P=0.444     |P=0.149N     P=0.160      P=0.503N     P=0.521N     | 
|POLY 1.5           |     P=0.336      P=0.499N     P=0.552N     P=0.471     |P=0.146N     P=0.153      P=0.500N     P=0.518N     | 
|POLY 6             |     P=0.290      P=0.529N     P=0.585N     P=0.408     |P=0.153N     P=0.174      P=0.503N     P=0.521N     | 
|LOGISTIC REGRESSION|     P=0.317      P=0.504N     P=0.598N     P=0.348     |P=0.167N     P=0.190      P=0.491N     P=0.516N     | 
|COCH-ARM / FISHERS |     P=0.371      P=0.500N     P=0.514N     P=0.500     |P=0.142N     P=0.143      P=0.500N     P=0.514N     | 
|ORDER RESTRICTED   |     P=0.429      (e)          (e)          (e)         |P=0.271N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/49 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/43.34      2/41.44      1/39.19      1/40.35     |0/44.12      1/46.25      0/44.36      0/42.28      | 
|POLY-3 PERCENT (g) |     2.3%         4.8%         2.6%         2.5%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      724          729 (T)      729 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.477N     P=0.385      P=0.734      P=0.718     |P=0.435N     P=0.522      (e)          (e)          | 
|POLY 3             |     P=0.485N     P=0.484      P=0.738      P=0.745     |P=0.408N     P=0.509      (e)          (e)          | 
|POLY 1.5           |     P=0.476N     P=0.494      P=0.744      P=0.752     |P=0.411N     P=0.506      (e)          (e)          | 
|POLY 6             |     P=0.496N     P=0.469      P=0.732      P=0.734     |P=0.403N     P=0.516      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.486N     P=0.413      P=0.734      P=0.718     |(e)          P=0.522      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.462N     P=0.500      P=0.747      P=0.753N    |P=0.417N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.606N     (e)          (e)          (e)         |P=0.396N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   6/49 (12%)   8/50 (16%)  |6/50 (12%)   12/50 (24%)  5/50 (10%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     7/43.34      7/42.86      6/39.30      8/40.35     |6/44.58      12/46.25     5/44.36      5/43.29      | 
|POLY-3 PERCENT (g) |     16.2%        16.3%        15.3%        19.8%       |13.5%        25.9%        11.3%        11.6%        | 
|TERMINAL (d)       |     7/34 (21%)   3/24 (13%)   5/30 (17%)   8/28 (29%)  |5/35 (14%)   12/39 (31%)  5/35 (14%)   2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      471          701          729 (T)     |595          729 (T)      729 (T)      602          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.412      P=0.387      P=0.599N     P=0.334     |P=0.161N     P=0.138      P=0.503N     P=0.542N     | 
|POLY 3             |     P=0.378      P=0.606      P=0.576N     P=0.439     |P=0.115N     P=0.108      P=0.503N     P=0.521N     | 
|POLY 1.5           |     P=0.405      P=0.612N     P=0.558N     P=0.468     |P=0.112N     P=0.103      P=0.500N     P=0.518N     | 
|POLY 6             |     P=0.349      P=0.584      P=0.594N     P=0.400     |P=0.117N     P=0.119      P=0.503N     P=0.521N     | 
|LOGISTIC REGRESSION|     P=0.375      P=0.598      P=0.608N     P=0.334     |P=0.133N     P=0.135      P=0.491N     P=0.516N     | 
|COCH-ARM / FISHERS |     P=0.447      P=0.613N     P=0.516N     P=0.500     |P=0.111N     P=0.096      P=0.500N     P=0.514N     | 
|ORDER RESTRICTED   |     P=0.499      (e)          (e)          (e)         |P=0.218N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     1/43.34      0/41.42      1/39.19      2/40.56     |0/44.12      0/46.25      0/44.36      2/42.28      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.6%         4.9%        |0.0%         0.0%         0.0%         4.7%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      674         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175      P=0.569N     P=0.734      P=0.432     |P=0.034 *    (e)          (e)          P=0.219      | 
|POLY 3             |     P=0.181      P=0.509N     P=0.738      P=0.477     |P=0.039 *    (e)          (e)          P=0.228      | 
|POLY 1.5           |     P=0.185      P=0.504N     P=0.744      P=0.488     |P=0.039 *    (e)          (e)          P=0.230      | 
|POLY 6             |     P=0.178      P=0.518N     P=0.732      P=0.463     |P=0.037 *    (e)          (e)          P=0.225      | 
|LOGISTIC REGRESSION|     P=0.170      (e)          P=0.734      P=0.464     |(e)          (e)          (e)          P=0.219      | 
|COCH-ARM / FISHERS |     P=0.190      P=0.500N     P=0.747      P=0.500     |P=0.042 *    (e)          (e)          P=0.242      | 
|ORDER RESTRICTED   |     P=0.206      (e)          (e)          (e)         |P=0.026 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     1/43.34      0/41.42      1/39.19      2/40.56     |0/44.12      1/46.25      1/44.36      2/42.28      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.6%         4.9%        |0.0%         2.2%         2.3%         4.7%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    1/39 (3%)    1/35 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      674         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175      P=0.569N     P=0.734      P=0.432     |P=0.141      P=0.522      P=0.500      P=0.219      | 
|POLY 3             |     P=0.181      P=0.509N     P=0.738      P=0.477     |P=0.162      P=0.509      P=0.501      P=0.228      | 
|POLY 1.5           |     P=0.185      P=0.504N     P=0.744      P=0.488     |P=0.166      P=0.506      P=0.501      P=0.230      | 
|POLY 6             |     P=0.178      P=0.518N     P=0.732      P=0.463     |P=0.157      P=0.516      P=0.502      P=0.225      | 
|LOGISTIC REGRESSION|     P=0.170      (e)          P=0.734      P=0.464     |(e)          P=0.522      P=0.500      P=0.219      | 
|COCH-ARM / FISHERS |     P=0.190      P=0.500N     P=0.747      P=0.500     |P=0.169      P=0.500      P=0.500      P=0.242      | 
|ORDER RESTRICTED   |     P=0.206      (e)          (e)          (e)         |P=0.110      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    10/50 (20%)  7/50 (14%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |                                                        |4/44.67      10/47.12     7/44.48      5/43.14      | 
|POLY-3 PERCENT (g) |                                                        |9.0%         21.2%        15.7%        11.6%        | 
|TERMINAL (d)       |                                                        |2/35 (6%)    8/39 (21%)   6/35 (17%)   4/32 (13%)   | 
|FIRST INCIDENCE    |                                                        |602          521          701          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.444N     P=0.113      P=0.267      P=0.449      | 
|POLY 3             |                                                        |P=0.374N     P=0.088      P=0.257      P=0.478      | 
|POLY 1.5           |                                                        |P=0.355N     P=0.082      P=0.261      P=0.488      | 
|POLY 6             |                                                        |P=0.401N     P=0.099      P=0.257      P=0.465      | 
|LOGISTIC REGRESSION|                                                        |P=0.369N     P=0.075      P=0.265      P=0.484      | 
|COCH-ARM / FISHERS |                                                        |P=0.334N     P=0.074      P=0.262      P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    10/50 (20%)  8/50 (16%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |                                                        |4/44.67      10/47.12     8/45.11      5/43.14      | 
|POLY-3 PERCENT (g) |                                                        |9.0%         21.2%        17.7%        11.6%        | 
|TERMINAL (d)       |                                                        |2/35 (6%)    8/39 (21%)   6/35 (17%)   4/32 (13%)   | 
|FIRST INCIDENCE    |                                                        |602          521          519          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.469N     P=0.113      P=0.184      P=0.449      | 
|POLY 3             |                                                        |P=0.400N     P=0.088      P=0.180      P=0.478      | 
|POLY 1.5           |                                                        |P=0.380N     P=0.082      P=0.181      P=0.488      | 
|POLY 6             |                                                        |P=0.429N     P=0.099      P=0.182      P=0.465      | 
|LOGISTIC REGRESSION|                                                        |P=0.376N     P=0.075      P=0.179      P=0.484      | 
|COCH-ARM / FISHERS |                                                        |P=0.357N     P=0.074      P=0.178      P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.235      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      0/39.73      1/40.35     |1/44.76      0/46.25      0/44.36      2/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.5%        |2.2%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |519          ---          ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179      (e)          (e)          P=0.461     |P=0.188      P=0.504N     P=0.508N     P=0.501      | 
|POLY 3             |     P=0.177      (e)          (e)          P=0.486     |P=0.189      P=0.493N     P=0.502N     P=0.490      | 
|POLY 1.5           |     P=0.180      (e)          (e)          P=0.492     |P=0.193      P=0.496N     P=0.501N     P=0.494      | 
|POLY 6             |     P=0.174      (e)          (e)          P=0.477     |P=0.183      P=0.488N     P=0.502N     P=0.486      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.461     |P=0.214      P=0.600N     P=0.581N     P=0.502      | 
|COCH-ARM / FISHERS |     P=0.184      (e)          (e)          P=0.500     |P=0.199      P=0.500N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.123      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.34      0/41.42      0/39.73      2/40.35     |1/44.76      0/46.25      0/44.36      2/43.48      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         5.0%        |2.2%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    0/30 (0%)    2/28 (7%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |519          ---          ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189      P=0.569N     P=0.525N     P=0.432     |P=0.188      P=0.504N     P=0.508N     P=0.501      | 
|POLY 3             |     P=0.191      P=0.509N     P=0.517N     P=0.475     |P=0.189      P=0.493N     P=0.502N     P=0.490      | 
|POLY 1.5           |     P=0.193      P=0.504N     P=0.512N     P=0.487     |P=0.193      P=0.496N     P=0.501N     P=0.494      | 
|POLY 6             |     P=0.190      P=0.518N     P=0.523N     P=0.459     |P=0.183      P=0.488N     P=0.502N     P=0.486      | 
|LOGISTIC REGRESSION|     P=0.189      (e)          (e)          P=0.432     |P=0.214      P=0.600N     P=0.581N     P=0.502      | 
|COCH-ARM / FISHERS |     P=0.199      P=0.500N     P=0.500N     P=0.500     |P=0.199      P=0.500N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.116      (e)          (e)          (e)         |P=0.123      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.73      0/41.42      1/40.23      0/40.35     |0/44.12      0/46.25      1/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         2.5%         0.0%        |0.0%         0.0%         2.3%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    1/35 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     616          ---          578          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296N     P=0.286N     P=0.552N     P=0.272N    |P=0.175      (e)          P=0.500      P=0.482      | 
|POLY 3             |     P=0.280N     P=0.249N     P=0.529N     P=0.255N    |P=0.189      (e)          P=0.501      P=0.495      | 
|POLY 1.5           |     P=0.280N     P=0.242N     P=0.520N     P=0.247N    |P=0.195      (e)          P=0.501      P=0.497      | 
|POLY 6             |     P=0.278N     P=0.261N     P=0.539N     P=0.268N    |P=0.182      (e)          P=0.502      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.265N     P=0.236N     P=0.480N     P=0.236N    |(e)          (e)          P=0.500      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.276N     P=0.247N     P=0.500N     P=0.247N    |P=0.202      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.086N     (e)          (e)          (e)         |P=0.246      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  31/50 (62%)  24/50 (48%)  13/50 (26%) |11/50 (22%)  13/50 (26%)  16/50 (32%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     17/45.90     31/46.84     24/42.73     13/42.99    |11/45.22     13/48.01     16/46.15     22/46.39     | 
|POLY-3 PERCENT (g) |     37.0%        66.2%        56.2%        30.2%       |24.3%        27.1%        34.7%        47.4%        | 
|TERMINAL (d)       |     11/34 (32%)  15/24 (63%)  16/30 (53%)  5/28 (18%)  |8/35 (23%)   8/39 (21%)   11/35 (31%)  12/32 (38%)  | 
|FIRST INCIDENCE    |     437          446          423          386         |605          509          519          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053N     P<0.001 **   P=0.059      P=0.446N    |P=0.004 **   P=0.521      P=0.202      P=0.017 *    | 
|POLY 3             |     P=0.026N*    P=0.003 **   P=0.051      P=0.325N    |P=0.006 **   P=0.474      P=0.195      P=0.016 *    | 
|POLY 1.5           |     P=0.019N*    P=0.004 **   P=0.066      P=0.291N    |P=0.007 **   P=0.448      P=0.192      P=0.016 *    | 
|POLY 6             |     P=0.038N*    P=0.002 **   P=0.040 *    P=0.367N    |P=0.006 **   P=0.512      P=0.205      P=0.017 *    | 
|LOGISTIC REGRESSION|     P=0.017N*    P=0.005 **   P=0.080      P=0.254N    |P=0.008 **   P=0.398      P=0.186      P=0.017 *    | 
|COCH-ARM / FISHERS |     P=0.015N*    P=0.004 **   P=0.111      P=0.257N    |P=0.008 **   P=0.408      P=0.184      P=0.016 *    | 
|ORDER RESTRICTED   |     P=0.015N*    (e)          (e)          (e)         |P=0.012 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    10/50 (20%) |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.80      1/41.42      0/39.73      10/44.35    |0/44.12      0/46.25      1/44.48      0/42.95      | 
|POLY-3 PERCENT (g) |     6.9%         2.4%         0.0%         22.6%       |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    1/24 (4%)    0/30 (0%)    2/28 (7%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     591          729 (T)      ---          512         |---          ---          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.405N     P=0.147N     P=0.031 *   |P=0.609      (e)          P=0.505      (e)          | 
|POLY 3             |     P<0.001 **   P=0.325N     P=0.137N     P=0.035 *   |P=0.610      (e)          P=0.502      (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.314N     P=0.131N     P=0.036 *   |P=0.620      (e)          P=0.501      (e)          | 
|POLY 6             |     P<0.001 **   P=0.344N     P=0.144N     P=0.035 *   |P=0.598      (e)          P=0.503      (e)          | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.312N     P=0.125N     P=0.044 *   |P=0.631      (e)          P=0.501      (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.309N     P=0.121N     P=0.036 *   |P=0.634      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.382      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    10/50 (20%) |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.80      1/41.42      0/39.73      10/44.35    |0/44.12      0/46.25      1/44.48      0/42.95      | 
|POLY-3 PERCENT (g) |     6.9%         2.4%         0.0%         22.6%       |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    1/24 (4%)    0/30 (0%)    2/28 (7%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     591          729 (T)      ---          512         |---          ---          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.405N     P=0.147N     P=0.031 *   |P=0.609      (e)          P=0.505      (e)          | 
|POLY 3             |     P<0.001 **   P=0.325N     P=0.137N     P=0.035 *   |P=0.610      (e)          P=0.502      (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.314N     P=0.131N     P=0.036 *   |P=0.620      (e)          P=0.501      (e)          | 
|POLY 6             |     P<0.001 **   P=0.344N     P=0.144N     P=0.035 *   |P=0.598      (e)          P=0.503      (e)          | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.312N     P=0.125N     P=0.044 *   |P=0.631      (e)          P=0.501      (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.309N     P=0.121N     P=0.036 *   |P=0.634      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.382      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  48/50 (96%)  45/50 (90%)  48/50 (96%) |42/50 (84%)  47/50 (94%)  43/50 (86%)  43/50 (86%)  | 
|POLY-3 RATE (b)    |     47/47.45     48/49.17     45/45.95     48/48.27    |42/47.70     47/48.52     43/46.55     43/46.42     | 
|POLY-3 PERCENT (g) |     99.0%        97.6%        97.9%        99.5%       |88.1%        96.9%        92.4%        92.6%        | 
|TERMINAL (d)       |     34/34 (100%) 24/24 (100%) 30/30 (100%) 28/28 (100%)|32/35 (91%)  38/39 (97%)  35/35 (100%) 32/32 (100%) | 
|FIRST INCIDENCE    |     516          437          437          423         |519          509          441          566          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320      P=0.025 *    P=0.297      P=0.085     |P=0.168      P=0.559      P=0.516      P=0.258      | 
|POLY 3             |     P=0.456      P=0.630N     P=0.761N     P=0.987     |P=0.538      P=0.085      P=0.342      P=0.327      | 
|POLY 1.5           |     P=0.484      P=0.688N     P=0.584N     P=0.766     |P=0.484N     P=0.092      P=0.442      P=0.408      | 
|POLY 6             |     P=0.517      P=0.685N     P=0.991N     P=1.000     |P=0.356      P=0.099      P=0.216      P=0.233      | 
|LOGISTIC REGRESSION|     P=0.287      P=0.608      P=0.756      P=0.270     |P=0.528N     P=0.112      P=0.454      P=0.386      | 
|COCH-ARM / FISHERS |     P=0.559      P=0.500      P=0.357N     P=0.500     |P=0.353N     P=0.100      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.362      (e)          (e)          (e)         |P=0.158      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 26      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  38/50 (76%)  35/50 (70%)  26/50 (52%) |16/50 (32%)  24/50 (48%)  20/50 (40%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     29/49.14     38/48.48     35/46.32     26/48.25    |16/46.21     24/49.04     20/46.47     32/48.13     | 
|POLY-3 PERCENT (g) |     59.0%        78.4%        75.6%        53.9%       |34.6%        48.9%        43.0%        66.5%        | 
|TERMINAL (d)       |     18/34 (53%)  17/24 (71%)  21/30 (70%)  8/28 (29%)  |11/35 (31%)  17/39 (44%)  14/35 (40%)  17/32 (53%)  | 
|FIRST INCIDENCE    |     222          437          253          356         |519          392          519          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241N     P=0.012 *    P=0.085      P=0.517     |P=0.003 **   P=0.180      P=0.286      P=0.003 **   | 
|POLY 3             |     P=0.084N     P=0.028 *    P=0.062      P=0.380N    |P=0.004 **   P=0.112      P=0.267      P<0.001 **   | 
|POLY 1.5           |     P=0.082N     P=0.034 *    P=0.080      P=0.369N    |P=0.004 **   P=0.098      P=0.269      P<0.001 **   | 
|POLY 6             |     P=0.081N     P=0.022 *    P=0.048 *    P=0.385N    |P=0.005 **   P=0.135      P=0.275      P=0.002 **   | 
|LOGISTIC REGRESSION|     P=0.053N     P=0.063      P=0.169      P=0.176N    |P=0.006 **   P=0.067      P=0.268      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.075N     P=0.044 *    P=0.149      P=0.344N    |P=0.005 **   P=0.076      P=0.266      P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.045N*    (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 49/50 (98%)  50/50 (100%)|45/50 (90%)  49/50 (98%)  48/50 (96%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     49/49.00     50/50.00    |45/48.47     49/50.00     48/48.54     49/49.04     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |92.8%        98.0%        98.9%        99.9%        | 
|TERMINAL (d)       |     34/34 (100%) 24/24 (100%) 30/30 (100%) 28/28 (100%)|33/35 (94%)  38/39 (97%)  35/35 (100%) 32/32 (100%) | 
|FIRST INCIDENCE    |     222          437          253          356         |519          392          441          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.340      (e)          P=0.250      (e)         |P=0.047 *    P=0.514N     P=0.368      P=0.130      | 
|POLY 3             |     P=1.000N     (e)          P=1.000N     (e)         |P=0.053      P=0.219      P=0.138      P=0.077      | 
|POLY 1.5           |     P=1.000N     (e)          P=1.000N     (e)         |P=0.072      P=0.184      P=0.182      P=0.076      | 
|POLY 6             |     P=1.000N     (e)          P=1.000N     (e)         |P=0.051      P=0.264      P=0.113      P=0.092      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.081      P=0.136      P=0.180      P=0.060      | 
|COCH-ARM / FISHERS |     P=0.634N     (e)          P=0.500N     (e)         |P=0.158      P=0.102      P=0.218      P=0.102      | 
|ORDER RESTRICTED   |     P=0.379N     (e)          (e)          (e)         |P=0.011 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.