National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19266

TDMS Study 96017-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 04/14/04       
EXPERIMENT: 96017 TEST: 05                                                                                     TIME: 09:29:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HERSCHELL, GILES                                                                                  CAS: 631-64-1        
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                                                            FINAL#1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 04/14/04       
EXPERIMENT: 96017 TEST: 05                                                                                     TIME: 09:29:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HERSCHELL, GILES                                                                                  CAS: 631-64-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF   WATER DISINFECTION BYPRODUCTS (DIBROMOAC                                                                       
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
                                       Degeneration Fatty                                                                           
Eye                                    Cataract                                                                                     
Heart                                  Thrombosis                                                                                   
Kidney                                 Nephropathy                                                                                  
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Inflammation Granulomatous                                                                   
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Centrilobular                   Necrosis                                                                                     
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mesenteric                 Hyperplasia Lymphoid                                                                         
Lymph Node: Mediastinal                Hyperplasia Lymphoid                                                                         
Mammary Gland                          Cyst                                                                                         
Mesentery: Fat                         Necrosis                                                                                     
Pancreas                               Atrophy                                                                                      
Pancreas: Acinus                       Hyperplasia Focal                                                                            
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
                                       Hyperplasia Focal                                                                            
Preputial Gland                        Cyst                                                                                         
Prostate                               Inflammation Chronic                                                                         
Spleen                                 Pigmentation                                                                                 
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Edema                                                                                        
                                       Erosion                                                                                      
Testes: Germinal Epithelium            Atrophy                                                                                      
Thymus                                 Cyst                                                                                         
Thyroid Gland                          Ultimobranchial Cyst                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
Clitoral Gland                         Cyst                                                                                         
Heart                                  Cardiomyopathy                                                                               
Intestine Large, Colon                 Edema                                                                                        
Islets, Pancreatic                     Metaplasia Hepatocyte                                                                        
Kidney                                 Inflammation Chronic                                                                         
                                       Nephropathy                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 04/14/04       
EXPERIMENT: 96017 TEST: 05                                                                                     TIME: 09:29:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HERSCHELL, GILES                                                                                  CAS: 631-64-1        
                                       Eosinophilic Focus                                                                           
                                       Inflammation Granulomatous                                                                   
                                       Mixed Cell Focus                                                                             
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mesenteric                 Hyperplasia Lymphoid                                                                         
Lymph Node: Mediastinal                Hyperplasia Lymphoid                                                                         
Mammary Gland                          Cyst                                                                                         
Pancreas                               Atrophy                                                                                      
Pituitary Gland: Pars Distalis         Angiectasis                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Ulcer                                                                                        
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Uterus                                 Inflammation Chronic                                                                         
Vagina                                 Cyst                                                                                         
                                       Inflammation                                                                                 
===============================================================                                                                     
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/49 (53%)  18/50 (36%)  20/49 (41%)  14/50 (28%) |17/49 (35%)  8/50 (16%)   6/50 (12%)   6/49 (12%)   | 
|POLY-3 RATE (b)    |     26/42.84     18/43.11     20/39.96     14/40.67    |17/43.58     8/46.25      6/45.78      6/43.47      | 
|POLY-3 PERCENT (g) |     60.7%        41.8%        50.1%        34.4%       |39.0%        17.3%        13.1%        13.8%        | 
|TERMINAL (d)       |     24/34 (71%)  10/24 (42%)  17/30 (57%)  12/28 (43%) |16/35 (46%)  8/39 (21%)   4/35 (11%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     692          519          590          674         |632          729 (T)      441          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.050N     P=0.467N     P=0.321N     P=0.052N    |P=0.036N*    P=0.013N*    P=0.009N**   P=0.015N*    | 
|POLY 3             |     P=0.044N*    P=0.054N     P=0.218N     P=0.010N*   |P=0.017N*    P=0.017N*    P=0.004N**   P=0.006N**   | 
|POLY 1.5           |     P=0.037N*    P=0.054N     P=0.199N     P=0.009N**  |P=0.016N*    P=0.020N*    P=0.004N**   P=0.006N**   | 
|POLY 6             |     P=0.056N     P=0.059N     P=0.240N     P=0.015N*   |P=0.018N*    P=0.013N*    P=0.003N**   P=0.005N**   | 
|LOGISTIC REGRESSION|     P=0.061N     P=0.126N     P=0.322N     P=0.035N*   |P=0.020N*    P=0.010N*    P=0.007N**   P=0.009N**   | 
|COCH-ARM / FISHERS |     P=0.031N*    P=0.066N     P=0.156N     P=0.010N*   |P=0.018N*    P=0.028N*    P=0.007N**   P=0.008N**   | 
|ORDER RESTRICTED   |     P=0.008N**   (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Fatty                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   12/50 (24%)  9/49 (18%)   4/50 (8%)   |14/49 (29%)  19/50 (38%)  15/50 (30%)  14/49 (29%)  | 
|POLY-3 RATE (b)    |     5/42.73      12/42.94     9/40.28      4/41.38     |14/43.23     19/47.12     15/44.48     14/42.95     | 
|POLY-3 PERCENT (g) |     11.7%        28.0%        22.4%        9.7%        |32.4%        40.3%        33.7%        32.6%        | 
|TERMINAL (d)       |     4/34 (12%)   6/24 (25%)   5/30 (17%)   2/28 (7%)   |14/35 (40%)  16/39 (41%)  14/35 (40%)  12/32 (38%)  | 
|FIRST INCIDENCE    |     693          510          602          512         |729 (T)      520          701          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172N     P=0.017 *    P=0.138      P=0.598N    |P=0.510N     P=0.312      P=0.503      P=0.482      | 
|POLY 3             |     P=0.153N     P=0.050      P=0.157      P=0.520N    |P=0.361N     P=0.285      P=0.537      P=0.583      | 
|POLY 1.5           |     P=0.140N     P=0.055      P=0.166      P=0.504N    |P=0.341N     P=0.257      P=0.535      P=0.586      | 
|POLY 6             |     P=0.171N     P=0.042 *    P=0.150      P=0.544N    |P=0.391N     P=0.337      P=0.549      P=0.583      | 
|LOGISTIC REGRESSION|     P=0.147N     P=0.049 *    P=0.149      P=0.507N    |P=0.442N     P=0.311      P=0.555      P=0.523      | 
|COCH-ARM / FISHERS |     P=0.128N     P=0.059      P=0.194      P=0.487N    |P=0.316N     P=0.217      P=0.526      P=0.588N     | 
|ORDER RESTRICTED   |     P=0.141N     (e)          (e)          (e)         |P=0.552N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/49 (12%)   4/50 (8%)    2/49 (4%)    6/50 (12%)  |8/49 (16%)   6/50 (12%)   4/50 (8%)    5/49 (10%)   | 
|POLY-3 RATE (b)    |     6/42.70      4/41.46      2/39.19      6/40.90     |8/44.53      6/46.25      4/44.36      5/42.48      | 
|POLY-3 PERCENT (g) |     14.1%        9.7%         5.1%         14.7%       |18.0%        13.0%        9.0%         11.8%        | 
|TERMINAL (d)       |     5/34 (15%)   3/24 (13%)   2/30 (7%)    5/28 (18%)  |5/35 (14%)   6/39 (15%)   4/35 (11%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     703          721          729 (T)      561         |595          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.475      P=0.585N     P=0.180N     P=0.489     |P=0.308N     P=0.326N     P=0.182N     P=0.330N     | 
|POLY 3             |     P=0.483      P=0.387N     P=0.161N     P=0.591     |P=0.263N     P=0.357N     P=0.177N     P=0.306N     | 
|POLY 1.5           |     P=0.493      P=0.369N     P=0.152N     P=0.612     |P=0.249N     P=0.361N     P=0.172N     P=0.292N     | 
|POLY 6             |     P=0.473      P=0.419N     P=0.172N     P=0.560     |P=0.285N     P=0.347N     P=0.183N     P=0.326N     | 
|LOGISTIC REGRESSION|     P=0.442      P=0.501N     P=0.177N     P=0.553     |P=0.257N     P=0.361N     P=0.167N     P=0.281N     | 
|COCH-ARM / FISHERS |     P=0.512      P=0.357N     P=0.134N     P=0.606N    |P=0.231N     P=0.371N     P=0.168N     P=0.276N     | 
|ORDER RESTRICTED   |     P=0.369      (e)          (e)          (e)         |P=0.236N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/49 (20%)  12/50 (24%)  13/49 (27%)  8/50 (16%)  |18/49 (37%)  19/50 (38%)  21/50 (42%)  17/49 (35%)  | 
|POLY-3 RATE (b)    |     10/42.59     12/43.14     13/39.42     8/43.30     |18/43.64     19/47.11     21/45.29     17/43.53     | 
|POLY-3 PERCENT (g) |     23.5%        27.8%        33.0%        18.5%       |41.2%        40.3%        46.4%        39.1%        | 
|TERMINAL (d)       |     10/34 (29%)  7/24 (29%)   11/30 (37%)  3/28 (11%)  |17/35 (49%)  16/39 (41%)  17/35 (49%)  13/32 (41%)  | 
|FIRST INCIDENCE    |     729 (T)      547          700          356         |611          521          622          621          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.342N     P=0.159      P=0.199      P=0.541N    |P=0.392      P=0.506N     P=0.346      P=0.553      | 
|POLY 3             |     P=0.283N     P=0.416      P=0.237      P=0.380N    |P=0.514N     P=0.550N     P=0.391      P=0.504N     | 
|POLY 1.5           |     P=0.277N     P=0.426      P=0.261      P=0.373N    |P=0.492N     P=0.583N     P=0.385      P=0.502N     | 
|POLY 6             |     P=0.296N     P=0.394      P=0.214      P=0.398N    |P=0.532      P=0.494N     P=0.414      P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.316N     P=0.364      P=0.184      P=0.369N    |P=0.512      P=0.528N     P=0.389      P=0.546N     | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.426      P=0.317      P=0.379N    |P=0.460N     P=0.531      P=0.371      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |P=0.577N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |3/49 (6%)    1/50 (2%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/42.59      1/41.42      0/39.19      1/40.64     |3/43.90      1/46.48      1/44.69      1/42.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         2.5%        |6.8%         2.2%         2.2%         2.4%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    0/30 (0%)    0/28 (0%)   |1/35 (3%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          651         |633          669          640          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.465      P=0.431      (e)          P=0.478     |P=0.333N     P=0.263N     P=0.304N     P=0.328N     | 
|POLY 3             |     P=0.466      P=0.494      (e)          P=0.491     |P=0.315N     P=0.285N     P=0.299N     P=0.317N     | 
|POLY 1.5           |     P=0.474      P=0.500      (e)          P=0.497     |P=0.307N     P=0.290N     P=0.298N     P=0.311N     | 
|POLY 6             |     P=0.455      P=0.485      (e)          P=0.482     |P=0.327N     P=0.276N     P=0.299N     P=0.325N     | 
|LOGISTIC REGRESSION|     P=0.476      P=0.431      (e)          P=0.510     |P=0.289N     P=0.319N     P=0.308N     P=0.304N     | 
|COCH-ARM / FISHERS |     P=0.484      P=0.505      (e)          P=0.505     |P=0.297N     P=0.301N     P=0.301N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.242      (e)          (e)          (e)         |P=0.192N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/49 (12%)   8/50 (16%)   7/49 (14%)   8/50 (16%)  |5/49 (10%)   1/50 (2%)    2/50 (4%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     6/42.59      8/41.65      7/39.30      8/41.01     |5/43.77      1/46.25      2/45.03      4/42.48      | 
|POLY-3 PERCENT (g) |     14.1%        19.2%        17.8%        19.5%       |11.4%        2.2%         4.4%         9.4%         | 
|TERMINAL (d)       |     6/34 (18%)   5/24 (21%)   6/30 (20%)   6/28 (21%)  |3/35 (9%)    1/39 (3%)    1/35 (3%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      697          700          624         |604          729 (T)      506          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372      P=0.171      P=0.405      P=0.255     |P=0.386      P=0.087N     P=0.220N     P=0.554N     | 
|POLY 3             |     P=0.379      P=0.367      P=0.438      P=0.356     |P=0.422      P=0.089N     P=0.204N     P=0.519N     | 
|POLY 1.5           |     P=0.398      P=0.388      P=0.457      P=0.378     |P=0.434      P=0.092N     P=0.205N     P=0.510N     | 
|POLY 6             |     P=0.358      P=0.334      P=0.417      P=0.327     |P=0.402      P=0.084N     P=0.202N     P=0.532N     | 
|LOGISTIC REGRESSION|     P=0.331      P=0.241      P=0.395      P=0.299     |P=0.447      P=0.094N     P=0.213N     P=0.515N     | 
|COCH-ARM / FISHERS |     P=0.427      P=0.403      P=0.500      P=0.403     |P=0.452      P=0.098N     P=0.210N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.405      (e)          (e)          (e)         |P=0.203N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    4/49 (8%)    2/48 (4%)    5/50 (10%)  |5/50 (10%)   8/50 (16%)   5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/42.59      4/41.61      2/39.45      5/41.80     |5/44.23      8/47.91      5/45.63      3/44.22      | 
|POLY-3 PERCENT (g) |     4.7%         9.6%         5.1%         12.0%       |11.3%        16.7%        11.0%        6.8%         | 
|TERMINAL (d)       |     2/34 (6%)    0/24 (0%)    1/30 (3%)    1/28 (4%)   |4/35 (11%)   5/39 (13%)   2/35 (6%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      618          402          570         |701          392          441          566          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.227      P=0.251      P=0.658      P=0.170     |P=0.181N     P=0.347      P=0.621N     P=0.397N     | 
|POLY 3             |     P=0.248      P=0.326      P=0.666      P=0.207     |P=0.137N     P=0.330      P=0.611N     P=0.356N     | 
|POLY 1.5           |     P=0.255      P=0.334      P=0.672      P=0.216     |P=0.134N     P=0.309      P=0.617N     P=0.356N     | 
|POLY 6             |     P=0.240      P=0.313      P=0.660      P=0.198     |P=0.143N     P=0.360      P=0.600N     P=0.355N     | 
|LOGISTIC REGRESSION|     P=0.277      P=0.327      P=0.689N     P=0.228     |P=0.108N     P=0.252      P=0.627      P=0.353N     | 
|COCH-ARM / FISHERS |     P=0.267      P=0.339      P=0.684      P=0.226     |P=0.128N     P=0.277      P=0.630N     P=0.357N     | 
|ORDER RESTRICTED   |     P=0.163      (e)          (e)          (e)         |P=0.227N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    3/48 (6%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.59      0/40.86      3/38.73      0/40.35     |0/44.12      1/46.25      0/44.36      2/43.70      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.8%         0.0%        |0.0%         2.2%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    2/30 (7%)    0/28 (0%)   |0/35 (0%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          700          ---         |---          729 (T)      ---          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434      (e)          P=0.104      (e)         |P=0.164      P=0.522      (e)          P=0.237      | 
|POLY 3             |     P=0.421      (e)          P=0.102      (e)         |P=0.177      P=0.509      (e)          P=0.235      | 
|POLY 1.5           |     P=0.437      (e)          P=0.106      (e)         |P=0.178      P=0.506      (e)          P=0.236      | 
|POLY 6             |     P=0.398      (e)          P=0.098      (e)         |P=0.176      P=0.516      (e)          P=0.234      | 
|LOGISTIC REGRESSION|     P=0.425      (e)          P=0.098      (e)         |P=0.189      P=0.522      (e)          P=0.237      | 
|COCH-ARM / FISHERS |     P=0.454      (e)          P=0.117      (e)         |P=0.179      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.146      (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   7/50 (14%)   2/50 (4%)   |6/50 (12%)   9/50 (18%)   7/50 (14%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     7/44.99      5/42.84      7/41.08      2/40.56     |6/44.65      9/46.47      7/45.22      5/43.53      | 
|POLY-3 PERCENT (g) |     15.6%        11.7%        17.0%        4.9%        |13.4%        19.4%        15.5%        11.5%        | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    3/30 (10%)   1/28 (4%)   |4/35 (11%)   7/39 (18%)   3/35 (9%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     591          602          560          674         |651          682          622          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.161N     P=0.475N     P=0.500      P=0.141N    |P=0.362N     P=0.386      P=0.514      P=0.541N     | 
|POLY 3             |     P=0.145N     P=0.414N     P=0.542      P=0.105N    |P=0.286N     P=0.316      P=0.510      P=0.518N     | 
|POLY 1.5           |     P=0.130N     P=0.394N     P=0.566      P=0.092N    |P=0.274N     P=0.305      P=0.507      P=0.510N     | 
|POLY 6             |     P=0.169N     P=0.447N     P=0.513      P=0.126N    |P=0.303N     P=0.336      P=0.519      P=0.528N     | 
|LOGISTIC REGRESSION|     P=0.109N     P=0.373N     P=0.614      P=0.079N    |P=0.284N     P=0.328      P=0.503      P=0.512N     | 
|COCH-ARM / FISHERS |     P=0.111N     P=0.380N     P=0.613N     P=0.080N    |P=0.259N     P=0.288      P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.101N     (e)          (e)          (e)         |P=0.410N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    3/50 (6%)   |1/50 (2%)    5/50 (10%)   2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/43.98      3/43.07      3/41.20      3/41.67     |1/44.47      5/47.89      2/44.75      3/43.62      | 
|POLY-3 PERCENT (g) |     2.3%         7.0%         7.3%         7.2%        |2.3%         10.4%        4.5%         6.9%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    1/39 (3%)    1/35 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     516          446          423          512         |633          509          618          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.314      P=0.300      P=0.292      P=0.291     |P=0.530      P=0.132      P=0.508      P=0.303      | 
|POLY 3             |     P=0.308      P=0.297      P=0.282      P=0.286     |P=0.565      P=0.120      P=0.502      P=0.298      | 
|POLY 1.5           |     P=0.320      P=0.304      P=0.289      P=0.295     |P=0.572      P=0.113      P=0.502      P=0.301      | 
|POLY 6             |     P=0.296      P=0.285      P=0.274      P=0.275     |P=0.558      P=0.131      P=0.505      P=0.295      | 
|LOGISTIC REGRESSION|     P=0.393      P=0.224      P=0.391      P=0.318     |P=0.540N     P=0.067      P=0.488      P=0.309      | 
|COCH-ARM / FISHERS |     P=0.337      P=0.309      P=0.309      P=0.309     |P=0.572N     P=0.102      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.261      (e)          (e)          (e)         |P=0.257      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.34      1/41.44      0/39.73      0/40.35     |0/44.12      2/46.25      0/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         0.0%        |0.0%         4.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    2/39 (5%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          724          ---          ---         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.423N     P=0.439      (e)          (e)         |P=0.640      P=0.262      (e)          P=0.482      | 
|POLY 3             |     P=0.427N     P=0.491      (e)          (e)         |P=0.602N     P=0.248      (e)          P=0.495      | 
|POLY 1.5           |     P=0.422N     P=0.496      (e)          (e)         |P=0.604N     P=0.244      (e)          P=0.497      | 
|POLY 6             |     P=0.435N     P=0.482      (e)          (e)         |P=0.601N     P=0.255      (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.429N     P=0.463      (e)          (e)         |(e)          P=0.262      (e)          P=0.482      | 
|COCH-ARM / FISHERS |     P=0.414N     P=0.500      (e)          (e)         |P=0.606N     P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.386N     (e)          (e)          (e)         |P=0.320      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/50 (24%)  4/50 (8%)    8/48 (17%)   13/49 (27%)  | 
|POLY-3 RATE (b)    |                                                        |12/45.68     4/46.25      8/43.39      13/43.07     | 
|POLY-3 PERCENT (g) |                                                        |26.3%        8.7%         18.4%        30.2%        | 
|TERMINAL (d)       |                                                        |7/35 (20%)   4/39 (10%)   4/33 (12%)   10/31 (32%)  | 
|FIRST INCIDENCE    |                                                        |604          729 (T)      622          580          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.062      P=0.020N*    P=0.256N     P=0.398      | 
|POLY 3             |                                                        |P=0.079      P=0.023N*    P=0.264N     P=0.431      | 
|POLY 1.5           |                                                        |P=0.089      P=0.024N*    P=0.259N     P=0.452      | 
|POLY 6             |                                                        |P=0.068      P=0.022N*    P=0.265N     P=0.402      | 
|LOGISTIC REGRESSION|                                                        |P=0.094      P=0.026N*    P=0.257N     P=0.459      | 
|COCH-ARM / FISHERS |                                                        |P=0.106      P=0.027N*    P=0.259N     P=0.477      | 
|ORDER RESTRICTED   |                                                        |P=0.101      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    4/50 (8%)    0/48 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.12      4/46.25      0/42.36      2/41.95      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         8.7%         0.0%         4.8%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    4/39 (10%)   0/33 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.477N     P=0.213      P=0.512N     P=0.457      | 
|POLY 3             |                                                        |P=0.416N     P=0.193      P=0.508N     P=0.482      | 
|POLY 1.5           |                                                        |P=0.413N     P=0.188      P=0.508N     P=0.487      | 
|POLY 6             |                                                        |P=0.418N     P=0.204      P=0.507N     P=0.476      | 
|LOGISTIC REGRESSION|                                                        |P=0.477N     P=0.213      (e)          P=0.457      | 
|COCH-ARM / FISHERS |                                                        |P=0.412N     P=0.181      P=0.510N     P=0.492      | 
|ORDER RESTRICTED   |                                                        |P=0.363N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    2/50 (4%)    5/48 (10%)   3/49 (6%)    | 
|POLY-3 RATE (b)    |                                                        |3/44.44      2/46.25      5/42.75      3/41.95      | 
|POLY-3 PERCENT (g) |                                                        |6.8%         4.3%         11.7%        7.2%         | 
|TERMINAL (d)       |                                                        |2/35 (6%)    2/39 (5%)    3/33 (9%)    3/31 (10%)   | 
|FIRST INCIDENCE    |                                                        |641          729 (T)      640          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.320      P=0.448N     P=0.347      P=0.615      | 
|POLY 3             |                                                        |P=0.354      P=0.482N     P=0.335      P=0.636      | 
|POLY 1.5           |                                                        |P=0.373      P=0.489N     P=0.336      P=0.644      | 
|POLY 6             |                                                        |P=0.329      P=0.469N     P=0.337      P=0.625      | 
|LOGISTIC REGRESSION|                                                        |P=0.355      P=0.482N     P=0.334      P=0.632      | 
|COCH-ARM / FISHERS |                                                        |P=0.397      P=0.500N     P=0.335      P=0.651      | 
|ORDER RESTRICTED   |                                                        |P=0.390      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/43.70      0/41.42      0/39.73      0/40.35     |2/44.12      2/46.44      2/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     6.9%         0.0%         0.0%         0.0%        |4.5%         4.3%         4.5%         2.3%         | 
|TERMINAL (d)       |     2/34 (6%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |2/35 (6%)    1/39 (3%)    2/35 (6%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     629          ---          ---          ---         |729 (T)      682          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.102N     P=0.171N     P=0.151N     P=0.153N    |P=0.423N     P=0.646N     P=0.695      P=0.531N     | 
|POLY 3             |     P=0.090N     P=0.128N     P=0.136N     P=0.133N    |P=0.386N     P=0.675N     P=0.692N     P=0.509N     | 
|POLY 1.5           |     P=0.092N     P=0.123N     P=0.130N     P=0.126N    |P=0.377N     P=0.683N     P=0.692N     P=0.505N     | 
|POLY 6             |     P=0.085N     P=0.138N     P=0.144N     P=0.143N    |P=0.401N     P=0.662N     P=0.690N     P=0.515N     | 
|LOGISTIC REGRESSION|     P=0.100N     P=0.124N     P=0.131N     P=0.128N    |P=0.407N     P=0.672N     P=0.695      P=0.531N     | 
|COCH-ARM / FISHERS |     P=0.094N     P=0.121N     P=0.121N     P=0.121N    |P=0.365N     P=0.691N     P=0.691N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.011N*    (e)          (e)          (e)         |P=0.475N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/43.34      0/41.42      0/39.73      1/40.70     |1/44.12      0/46.25      0/44.36      2/43.58      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         0.0%         2.5%        |2.3%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     2/34 (6%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |1/35 (3%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          631         |729 (T)      ---          ---          621          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.563N     P=0.318N     P=0.266N     P=0.551N    |P=0.182      P=0.478N     P=0.500N     P=0.492      | 
|POLY 3             |     P=0.552N     P=0.247N     P=0.257N     P=0.522N    |P=0.189      P=0.491N     P=0.499N     P=0.496      | 
|POLY 1.5           |     P=0.554N     P=0.241N     P=0.250N     P=0.512N    |P=0.193      P=0.494N     P=0.499N     P=0.498      | 
|POLY 6             |     P=0.545N     P=0.257N     P=0.264N     P=0.535N    |P=0.184      P=0.484N     P=0.498N     P=0.494      | 
|LOGISTIC REGRESSION|     P=0.564N     (e)          (e)          P=0.518N    |P=0.206      (e)          (e)          P=0.503      | 
|COCH-ARM / FISHERS |     P=0.550N     P=0.247N     P=0.247N     P=0.500N    |P=0.199      P=0.500N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.147N     (e)          (e)          (e)         |P=0.127      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  41/50 (82%)  43/50 (86%)  41/50 (82%) |37/50 (74%)  29/50 (58%)  34/50 (68%)  35/50 (70%)  | 
|POLY-3 RATE (b)    |     45/47.89     41/48.52     43/46.57     41/45.83    |37/46.21     29/48.41     34/47.18     35/45.96     | 
|POLY-3 PERCENT (g) |     94.0%        84.5%        92.3%        89.5%       |80.1%        59.9%        72.1%        76.2%        | 
|TERMINAL (d)       |     32/34 (94%)  21/24 (88%)  28/30 (93%)  26/28 (93%) |31/35 (89%)  25/39 (64%)  25/35 (71%)  28/32 (88%)  | 
|FIRST INCIDENCE    |     433          437          253          512         |595          509          430          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.500      P=0.176      P=0.330      P=0.341     |P=0.101      P=0.017N*    P=0.335N     P=0.517      | 
|POLY 3             |     P=0.524      P=0.105N     P=0.540N     P=0.320N    |P=0.259      P=0.023N*    P=0.244N     P=0.415N     | 
|POLY 1.5           |     P=0.477N     P=0.114N     P=0.483N     P=0.236N    |P=0.309      P=0.035N*    P=0.269N     P=0.402N     | 
|POLY 6             |     P=0.409      P=0.122N     P=0.626N     P=0.458N    |P=0.191      P=0.012N*    P=0.202N     P=0.449N     | 
|LOGISTIC REGRESSION|     P=0.399N     P=0.193N     P=0.583N     P=0.271N    |P=0.280      P=0.044N*    P=0.321N     P=0.490N     | 
|COCH-ARM / FISHERS |     P=0.299N     P=0.194N     P=0.380N     P=0.194N    |P=0.370      P=0.069N     P=0.330N     P=0.412N     | 
|ORDER RESTRICTED   |     P=0.279N     (e)          (e)          (e)         |P=0.179N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.34      4/41.71      1/39.73      1/40.72     |2/44.44      1/46.25      1/44.75      1/43.14      | 
|POLY-3 PERCENT (g) |     0.0%         9.6%         2.5%         2.5%        |4.5%         2.2%         2.2%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    1/30 (3%)    0/28 (0%)   |1/35 (3%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          693          729 (T)      624         |641          729 (T)      618          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381N     P=0.040 *    P=0.475      P=0.485     |P=0.473N     P=0.459N     P=0.489N     P=0.513N     | 
|POLY 3             |     P=0.379N     P=0.055      P=0.483      P=0.488     |P=0.455N     P=0.486N     P=0.498N     P=0.510N     | 
|POLY 1.5           |     P=0.366N     P=0.058      P=0.488      P=0.493     |P=0.448N     P=0.491N     P=0.498N     P=0.506N     | 
|POLY 6             |     P=0.398N     P=0.050      P=0.476      P=0.480     |P=0.465N     P=0.477N     P=0.495N     P=0.516N     | 
|LOGISTIC REGRESSION|     P=0.370N     P=0.052      P=0.475      P=0.509     |P=0.431N     P=0.498N     P=0.510N     P=0.499N     | 
|COCH-ARM / FISHERS |     P=0.350N     P=0.059      P=0.500      P=0.500     |P=0.439N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.171      (e)          (e)          (e)         |P=0.418N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    1/49 (2%)    1/48 (2%)    0/50 (0%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     0/41.99      1/40.50      1/38.73      0/40.35     |0/43.23      0/45.29      0/43.42      2/42.01      | 
|POLY-3 PERCENT (g) |     0.0%         2.5%         2.6%         0.0%        |0.0%         0.0%         0.0%         4.8%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      700          ---         |---          ---          ---          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.533N     P=0.431      P=0.483      (e)         |P=0.035 *    (e)          (e)          P=0.227      | 
|POLY 3             |     P=0.533N     P=0.493      P=0.484      (e)         |P=0.039 *    (e)          (e)          P=0.231      | 
|POLY 1.5           |     P=0.523N     P=0.499      P=0.489      (e)         |P=0.040 *    (e)          (e)          P=0.232      | 
|POLY 6             |     P=0.547N     P=0.482      P=0.479      (e)         |P=0.038 *    (e)          (e)          P=0.230      | 
|LOGISTIC REGRESSION|     P=0.532N     P=0.431      P=0.487      (e)         |P=0.040 *    (e)          (e)          P=0.231      | 
|COCH-ARM / FISHERS |     P=0.511N     P=0.505      P=0.500      (e)         |P=0.042 *    (e)          (e)          P=0.242      | 
|ORDER RESTRICTED   |     P=0.390      (e)          (e)          (e)         |P=0.027 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Metaplasia Hepatocyte                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |0/47 (0%)    1/49 (2%)    0/49 (0%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/41.99      0/41.42      0/38.61      0/40.35     |0/41.84      1/45.91      0/43.63      3/42.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         0.0%         7.1%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    1/39 (3%)    0/35 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          622          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.047 *    P=0.522      (e)          P=0.112      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.056      P=0.519      (e)          P=0.120      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.057      P=0.515      (e)          P=0.121      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.054      P=0.524      (e)          P=0.118      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.057      P=0.522      (e)          P=0.123      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.059      P=0.510      (e)          P=0.125      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.021 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.59      0/41.42      0/39.19      1/40.38     |0/44.12      0/46.25      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         0.0%         2.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          723         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560N     P=0.318N     P=0.266N     P=0.563N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.548N     P=0.243N     P=0.256N     P=0.519N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.551N     P=0.237N     P=0.250N     P=0.506N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.541N     P=0.254N     P=0.263N     P=0.536N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.574N     (e)          (e)          P=0.564N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.548N     P=0.242N     P=0.247N     P=0.492N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.144N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/42.59      1/41.50      0/39.19      1/40.38     |0/44.12      2/46.25      0/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |     2.4%         2.4%         0.0%         2.5%        |0.0%         4.3%         0.0%         4.7%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    2/39 (5%)    0/35 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      710          ---          723         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.591N     P=0.691      P=0.525N     P=0.721     |P=0.309      P=0.262      (e)          P=0.219      | 
|POLY 3             |     P=0.586N     P=0.755      P=0.517N     P=0.749     |P=0.349      P=0.248      (e)          P=0.231      | 
|POLY 1.5           |     P=0.583N     P=0.760N     P=0.511N     P=0.757     |P=0.351      P=0.244      (e)          P=0.234      | 
|POLY 6             |     P=0.589N     P=0.745      P=0.522N     P=0.738     |P=0.348      P=0.255      (e)          P=0.227      | 
|LOGISTIC REGRESSION|     P=0.605N     P=0.737      (e)          P=0.724     |(e)          P=0.262      (e)          P=0.219      | 
|COCH-ARM / FISHERS |     P=0.576N     P=0.747N     P=0.500N     P=0.747N    |P=0.354      P=0.247      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.552N     (e)          (e)          (e)         |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.59      0/41.42      0/39.19      0/40.35     |0/44.12      0/46.25      0/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.034 *    (e)          (e)          P=0.219      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.231      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.234      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.039 *    (e)          (e)          P=0.227      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.219      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.027 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     43/49 (88%)  48/50 (96%)  46/49 (94%)  47/50 (94%) |18/50 (36%)  32/50 (64%)  37/50 (74%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     43/46.34     48/48.69     46/46.77     47/47.83    |18/45.68     32/46.59     37/46.96     40/46.61     | 
|POLY-3 PERCENT (g) |     92.8%        98.6%        98.4%        98.3%       |39.4%        68.7%        78.8%        85.8%        | 
|TERMINAL (d)       |     33/34 (97%)  24/24 (100%) 30/30 (100%) 28/28 (100%)|15/35 (43%)  29/39 (74%)  31/35 (89%)  28/32 (88%)  | 
|FIRST INCIDENCE    |     437          437          253          386         |161          682          430          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      P=0.004 **   P=0.079      P=0.029 *   |P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.183      P=0.145      P=0.173      P=0.171     |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.242      P=0.146      P=0.166      P=0.202     |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.143      P=0.153      P=0.191      P=0.161     |P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.190      P=0.112      P=0.079      P=0.127     |P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.342      P=0.128      P=0.243      P=0.233     |P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    9/50 (18%)   8/49 (16%)   3/50 (6%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/42.66      9/41.58      8/39.61      3/40.64     |0/44.12      0/46.25      2/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |     7.0%         21.6%        20.2%        7.4%        |0.0%         0.0%         4.5%         4.7%         | 
|TERMINAL (d)       |     2/34 (6%)    7/24 (29%)   7/30 (23%)   2/28 (7%)   |0/35 (0%)    0/39 (0%)    2/35 (6%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     711          697          608          651         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.285N     P=0.016 *    P=0.065      P=0.577     |P=0.050      (e)          P=0.238      P=0.219      | 
|POLY 3             |     P=0.293N     P=0.051      P=0.075      P=0.640     |P=0.059      (e)          P=0.238      P=0.231      | 
|POLY 1.5           |     P=0.271N     P=0.058      P=0.081      P=0.655     |P=0.062      (e)          P=0.238      P=0.234      | 
|POLY 6             |     P=0.322N     P=0.041 *    P=0.068      P=0.619     |P=0.054      (e)          P=0.240      P=0.227      | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.026 *    P=0.067      P=0.619     |(e)          (e)          P=0.238      P=0.219      | 
|COCH-ARM / FISHERS |     P=0.248N     P=0.065      P=0.100      P=0.651N    |P=0.067      (e)          P=0.247      P=0.247      | 
|ORDER RESTRICTED   |     P=0.160      (e)          (e)          (e)         |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  4/50 (8%)    1/50 (2%)    1/50 (2%)   |36/50 (72%)  41/50 (82%)  29/50 (58%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     14/43.34     4/41.42      1/39.73      1/40.35     |36/45.23     41/47.22     29/45.25     15/43.28     | 
|POLY-3 PERCENT (g) |     32.3%        9.7%         2.5%         2.5%        |79.6%        86.8%        64.1%        34.7%        | 
|TERMINAL (d)       |     14/34 (41%)  4/24 (17%)   1/30 (3%)    1/28 (4%)   |32/35 (91%)  37/39 (95%)  27/35 (77%)  14/32 (44%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |602          521          441          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.046N*    P<0.001N**   P<0.001N**  |P<0.001N**   P=0.514      P=0.062N     P<0.001N**   | 
|POLY 3             |     P<0.001N**   P=0.009N**   P<0.001N**   P<0.001N**  |P<0.001N**   P=0.236      P=0.065N     P<0.001N**   | 
|POLY 1.5           |     P<0.001N**   P=0.008N**   P<0.001N**   P<0.001N**  |P<0.001N**   P=0.207      P=0.075N     P<0.001N**   | 
|POLY 6             |     P<0.001N**   P=0.011N*    P<0.001N**   P<0.001N**  |P<0.001N**   P=0.319      P=0.052N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.046N*    P<0.001N**   P<0.001N**  |P<0.001N**   P=0.445      P=0.053N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.009N**   P<0.001N**   P<0.001N**  |P<0.001N**   P=0.171      P=0.104N     P<0.001N**   | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  19/50 (38%)  16/50 (32%)  21/50 (42%) |8/50 (16%)   4/50 (8%)    14/50 (28%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     18/43.34     19/42.82     16/39.73     21/41.00    |8/44.12      4/46.37      14/45.04     18/42.95     | 
|POLY-3 PERCENT (g) |     41.5%        44.4%        40.3%        51.2%       |18.1%        8.6%         31.1%        41.9%        | 
|TERMINAL (d)       |     18/34 (53%)  14/24 (58%)  16/30 (53%)  20/28 (71%) |8/35 (23%)   3/39 (8%)    11/35 (31%)  18/32 (56%)  | 
|FIRST INCIDENCE    |     729 (T)      602          729 (T)      512         |729 (T)      701          640          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.253      P=0.096      P=0.586      P=0.077     |P<0.001 **   P=0.130N     P=0.116      P=0.006 **   | 
|POLY 3             |     P=0.243      P=0.480      P=0.543N     P=0.244     |P<0.001 **   P=0.153N     P=0.118      P=0.012 *    | 
|POLY 1.5           |     P=0.289      P=0.497      P=0.500N     P=0.290     |P<0.001 **   P=0.163N     P=0.117      P=0.014 *    | 
|POLY 6             |     P=0.187      P=0.451      P=0.592      P=0.184     |P<0.001 **   P=0.137N     P=0.126      P=0.009 **   | 
|LOGISTIC REGRESSION|     P=0.174      P=0.313      P=0.586      P=0.107     |P<0.001 **   P=0.117N     P=0.118      P=0.006 **   | 
|COCH-ARM / FISHERS |     P=0.355      P=0.500      P=0.417N     P=0.341     |P<0.001 **   P=0.178N     P=0.114      P=0.020 *    | 
|ORDER RESTRICTED   |     P=0.282      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    9/50 (18%)   11/50 (22%)  15/50 (30%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/43.34      9/41.57      11/40.48     15/42.32    |0/44.12      0/46.25      0/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     6.9%         21.7%        27.2%        35.4%       |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     3/34 (9%)    8/24 (33%)   9/30 (30%)   10/28 (36%) |0/35 (0%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      691          521          570         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.013 *    P=0.011 *    P<0.001 **  |P=0.165      (e)          (e)          P=0.482      | 
|POLY 3             |     P=0.002 **   P=0.048 *    P=0.012 *    P<0.001 **  |P=0.178      (e)          (e)          P=0.495      | 
|POLY 1.5           |     P=0.002 **   P=0.055      P=0.014 *    P<0.001 **  |P=0.181      (e)          (e)          P=0.497      | 
|POLY 6             |     P=0.002 **   P=0.039 *    P=0.010 *    P<0.001 **  |P=0.175      (e)          (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.022 *    P=0.012 *    P<0.001 **  |(e)          (e)          (e)          P=0.482      | 
|COCH-ARM / FISHERS |     P=0.004 **   P=0.061      P=0.020 *    P=0.002 **  |P=0.184      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.115      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  4/50 (8%)    3/50 (6%)    9/50 (18%)  |4/50 (8%)    4/50 (8%)    5/50 (10%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     16/44.00     4/41.53      3/39.73      9/40.87     |4/44.12      4/46.37      5/44.49      9/42.95      | 
|POLY-3 PERCENT (g) |     36.4%        9.6%         7.6%         22.0%       |9.1%         8.6%         11.2%        21.0%        | 
|TERMINAL (d)       |     13/34 (38%)  3/24 (13%)   3/30 (10%)   8/28 (29%)  |4/35 (11%)   3/39 (8%)    4/35 (11%)   9/32 (28%)   | 
|FIRST INCIDENCE    |     622          701          729 (T)      571         |729 (T)      699          696          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.281N     P=0.022N*    P=0.003N**   P=0.195N    |P=0.024 *    P=0.580N     P=0.504      P=0.080      | 
|POLY 3             |     P=0.256N     P=0.003N**   P<0.001N**   P=0.110N    |P=0.040 *    P=0.616N     P=0.505      P=0.103      | 
|POLY 1.5           |     P=0.252N     P=0.002N**   P<0.001N**   P=0.094N    |P=0.044 *    P=0.627N     P=0.504      P=0.109      | 
|POLY 6             |     P=0.257N     P=0.004N**   P=0.002N**   P=0.137N    |P=0.034 *    P=0.596N     P=0.511      P=0.095      | 
|LOGISTIC REGRESSION|     P=0.319N     P=0.005N**   P=0.002N**   P=0.141N    |P=0.023 *    P=0.575N     P=0.518      P=0.080      | 
|COCH-ARM / FISHERS |     P=0.244N     P=0.003N**   P<0.001N**   P=0.083N    |P=0.051      P=0.643N     P=0.500      P=0.117      | 
|ORDER RESTRICTED   |     P=0.002N**   (e)          (e)          (e)         |P=0.065      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    5/50 (10%)  |3/50 (6%)    9/50 (18%)   2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/43.34      1/41.57      2/40.15      5/41.35     |3/44.71      9/46.44      2/44.74      5/43.14      | 
|POLY-3 PERCENT (g) |     4.6%         2.4%         5.0%         12.1%       |6.7%         19.4%        4.5%         11.6%        | 
|TERMINAL (d)       |     2/34 (6%)    0/24 (0%)    1/30 (3%)    3/28 (11%)  |1/35 (3%)    8/39 (21%)   1/35 (3%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      691          607          514         |633          682          622          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054      P=0.596N     P=0.644      P=0.164     |P=0.438N     P=0.098      P=0.494N     P=0.323      | 
|POLY 3             |     P=0.055      P=0.515N     P=0.667      P=0.196     |P=0.363N     P=0.068      P=0.500N     P=0.336      | 
|POLY 1.5           |     P=0.057      P=0.506N     P=0.675      P=0.206     |P=0.354N     P=0.065      P=0.499N     P=0.346      | 
|POLY 6             |     P=0.053      P=0.529N     P=0.658      P=0.184     |P=0.375N     P=0.074      P=0.499N     P=0.324      | 
|LOGISTIC REGRESSION|     P=0.057      P=0.539N     P=0.671      P=0.208     |P=0.376N     P=0.070      P=0.506N     P=0.345      | 
|COCH-ARM / FISHERS |     P=0.061      P=0.500N     P=0.691N     P=0.218     |P=0.346N     P=0.061      P=0.500N     P=0.357      | 
|ORDER RESTRICTED   |     P=0.069      (e)          (e)          (e)         |P=0.340      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      0/39.73      0/40.35     |2/44.12      3/46.44      3/44.42      1/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         6.5%         6.8%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |2/35 (6%)    2/39 (5%)    2/35 (6%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      682          715          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.373N     P=0.557      P=0.503      P=0.531N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.332N     P=0.523      P=0.503      P=0.509N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.322N     P=0.514      P=0.503      P=0.505N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.347N     P=0.540      P=0.507      P=0.515N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.354N     P=0.537      P=0.513      P=0.531N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.310N     P=0.500      P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.358N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    0/50 (0%)    1/50 (2%)   |8/50 (16%)   0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/43.34      1/41.74      0/39.73      1/40.35     |8/44.47      0/46.25      1/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |     13.8%        2.4%         0.0%         2.5%        |18.0%        0.0%         2.3%         4.7%         | 
|TERMINAL (d)       |     6/34 (18%)   0/24 (0%)    0/30 (0%)    1/28 (4%)   |7/35 (20%)   0/39 (0%)    1/35 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      641          ---          729 (T)     |632          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.059N     P=0.120N     P=0.024N*    P=0.092N    |P=0.159N     P=0.003N**   P=0.018N*    P=0.063N     | 
|POLY 3             |     P=0.053N     P=0.061N     P=0.020N*    P=0.067N    |P=0.134N     P=0.003N**   P=0.015N*    P=0.050N     | 
|POLY 1.5           |     P=0.053N     P=0.058N     P=0.018N*    P=0.062N    |P=0.126N     P=0.003N**   P=0.016N*    P=0.048N*    | 
|POLY 6             |     P=0.051N     P=0.067N     P=0.022N*    P=0.075N    |P=0.147N     P=0.002N**   P=0.015N*    P=0.053N     | 
|LOGISTIC REGRESSION|     P=0.065N     P=0.075N     (e)          P=0.092N    |P=0.146N     P=0.003N**   P=0.016N*    P=0.055N     | 
|COCH-ARM / FISHERS |     P=0.054N     P=0.056N     P=0.013N*    P=0.056N    |P=0.123N     P=0.003N**   P=0.015N*    P=0.046N*    | 
|ORDER RESTRICTED   |     P=0.003N**   (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   1/50 (2%)    5/50 (10%)   2/50 (4%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     8/43.34      1/41.42      5/40.65      2/40.85     |1/44.12      1/46.44      1/44.65      4/43.19      | 
|POLY-3 PERCENT (g) |     18.5%        2.4%         12.3%        4.9%        |2.3%         2.2%         2.2%         9.3%         | 
|TERMINAL (d)       |     8/34 (24%)   1/24 (4%)    3/30 (10%)   0/28 (0%)   |1/35 (3%)    0/39 (0%)    0/35 (0%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      580          651         |729 (T)      682          651          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210N     P=0.052N     P=0.362N     P=0.088N    |P=0.048 *    P=0.726N     P=0.755N     P=0.160      | 
|POLY 3             |     P=0.188N     P=0.018N*    P=0.317N     P=0.054N    |P=0.059      P=0.749N     P=0.758N     P=0.172      | 
|POLY 1.5           |     P=0.187N     P=0.017N*    P=0.306N     P=0.050N    |P=0.062      P=0.754N     P=0.759N     P=0.175      | 
|POLY 6             |     P=0.184N     P=0.021N*    P=0.326N     P=0.060N    |P=0.056      P=0.741N     P=0.756N     P=0.168      | 
|LOGISTIC REGRESSION|     P=0.211N     P=0.052N     P=0.339N     P=0.069N    |P=0.061      P=0.759N     P=0.762      P=0.165      | 
|COCH-ARM / FISHERS |     P=0.183N     P=0.015N*    P=0.277N     P=0.046N*   |P=0.065      P=0.753N     P=0.753N     P=0.181      | 
|ORDER RESTRICTED   |     P=0.021N*    (e)          (e)          (e)         |P=0.068      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      3/40.65      2/41.20     |1/44.58      0/46.25      0/44.36      1/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.4%         4.9%        |2.2%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          578          386         |595          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.066      (e)          P=0.100      P=0.218     |P=0.496      P=0.508N     P=0.508N     P=0.743      | 
|POLY 3             |     P=0.064      (e)          P=0.107      P=0.226     |P=0.501      P=0.493N     P=0.501N     P=0.752      | 
|POLY 1.5           |     P=0.067      (e)          P=0.110      P=0.232     |P=0.508      P=0.495N     P=0.500N     P=0.756      | 
|POLY 6             |     P=0.059      (e)          P=0.104      P=0.217     |P=0.492      P=0.487N     P=0.501N     P=0.748      | 
|LOGISTIC REGRESSION|     P=0.076      (e)          P=0.128      P=0.237     |P=0.527      P=0.551N     P=0.535N     P=0.760N     | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.121      P=0.247     |P=0.518      P=0.500N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.071      (e)          (e)          (e)         |P=0.387      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     43/50 (86%)  42/50 (84%)  35/50 (70%)  38/50 (76%) |17/50 (34%)  15/50 (30%)  15/50 (30%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     43/46.95     42/46.85     35/43.12     38/44.96    |17/45.49     15/46.55     15/45.38     19/44.58     | 
|POLY-3 PERCENT (g) |     91.6%        89.7%        81.2%        84.5%       |37.4%        32.2%        33.1%        42.6%        | 
|TERMINAL (d)       |     32/34 (94%)  22/24 (92%)  26/30 (87%)  25/28 (89%) |13/35 (37%)  13/39 (33%)  13/35 (37%)  14/32 (44%)  | 
|FIRST INCIDENCE    |     433          446          437          386         |595          682          519          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.277N     P=0.061      P=0.337N     P=0.430     |P=0.148      P=0.283N     P=0.418N     P=0.319      | 
|POLY 3             |     P=0.112N     P=0.515N     P=0.099N     P=0.207N    |P=0.249      P=0.382N     P=0.416N     P=0.384      | 
|POLY 1.5           |     P=0.087N     P=0.478N     P=0.071N     P=0.162N    |P=0.270      P=0.393N     P=0.411N     P=0.399      | 
|POLY 6             |     P=0.163N     P=0.589N     P=0.165N     P=0.295N    |P=0.221      P=0.359N     P=0.420N     P=0.365      | 
|LOGISTIC REGRESSION|     P=0.134N     P=0.549N     P=0.111N     P=0.242N    |P=0.234      P=0.347N     P=0.408N     P=0.383      | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.500N     P=0.045N*    P=0.154N    |P=0.298      P=0.415N     P=0.415N     P=0.418      | 
|ORDER RESTRICTED   |     P=0.122N     (e)          (e)          (e)         |P=0.321      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    5/50 (10%)  |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.34      1/41.56      1/39.73      5/42.71     |1/44.23      1/47.10      0/44.36      1/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.5%         11.7%       |2.3%         2.1%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          693          729 (T)      521         |701          392          ---          566          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.471      P=0.475      P=0.032 *   |P=0.594N     P=0.747N     P=0.495N     P=0.744      | 
|POLY 3             |     P=0.006 **   P=0.492      P=0.483      P=0.029 *   |P=0.584N     P=0.746N     P=0.499N     P=0.757      | 
|POLY 1.5           |     P=0.006 **   P=0.497      P=0.488      P=0.030 *   |P=0.581N     P=0.752N     P=0.499N     P=0.759      | 
|POLY 6             |     P=0.006 **   P=0.483      P=0.476      P=0.028 *   |P=0.587N     P=0.739N     P=0.499N     P=0.755      | 
|LOGISTIC REGRESSION|     P=0.007 **   P=0.496      P=0.475      P=0.034 *   |P=0.557N     P=0.692      P=0.499N     P=0.761N     | 
|COCH-ARM / FISHERS |     P=0.007 **   P=0.500      P=0.500      P=0.028 *   |P=0.579N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.003 **   (e)          (e)          (e)         |P=0.539N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  6/50 (12%)   12/50 (24%)  12/50 (24%) |3/50 (6%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     14/44.86     6/42.53      12/42.28     12/42.95    |3/45.08      2/46.44      0/44.36      1/43.24      | 
|POLY-3 PERCENT (g) |     31.2%        14.1%        28.4%        27.9%       |6.7%         4.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     9/34 (27%)   3/24 (13%)   6/30 (20%)   8/28 (29%)  |0/35 (0%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     591          437          437          356         |632          682          ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.286      P=0.137N     P=0.559N     P=0.580     |P=0.183N     P=0.442N     P=0.121N     P=0.310N     | 
|POLY 3             |     P=0.315      P=0.047N*    P=0.479N     P=0.459N    |P=0.167N     P=0.487N     P=0.121N     P=0.320N     | 
|POLY 1.5           |     P=0.323      P=0.041N*    P=0.458N     P=0.430N    |P=0.163N     P=0.491N     P=0.120N     P=0.313N     | 
|POLY 6             |     P=0.304      P=0.061N     P=0.504N     P=0.512N    |P=0.173N     P=0.478N     P=0.123N     P=0.330N     | 
|LOGISTIC REGRESSION|     P=0.332      P=0.042N*    P=0.444N     P=0.415N    |P=0.150N     P=0.531N     P=0.129N     P=0.299N     | 
|COCH-ARM / FISHERS |     P=0.336      P=0.039N*    P=0.410N     P=0.410N    |P=0.158N     P=0.500N     P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.314N     (e)          (e)          (e)         |P=0.116N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Serosa                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.34      0/41.42      0/39.73      0/40.35     |2/44.54      2/46.29      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |4.5%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |1/35 (3%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |611          720          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372N     P=0.569N     P=0.525N     P=0.539N    |P=0.077N     P=0.657N     P=0.235N     P=0.250N     | 
|POLY 3             |     P=0.363N     P=0.509N     P=0.517N     P=0.514N    |P=0.069N     P=0.680N     P=0.238N     P=0.245N     | 
|POLY 1.5           |     P=0.367N     P=0.504N     P=0.512N     P=0.508N    |P=0.068N     P=0.685N     P=0.237N     P=0.242N     | 
|POLY 6             |     P=0.356N     P=0.518N     P=0.523N     P=0.523N    |P=0.072N     P=0.670N     P=0.238N     P=0.250N     | 
|LOGISTIC REGRESSION|     P=0.372N     (e)          (e)          (e)         |P=0.067N     P=0.696N     P=0.241N     P=0.235N     | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.500N     P=0.500N     P=0.500N    |P=0.067N     P=0.691N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.133N     (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    6/50 (12%)   2/50 (4%)   |4/50 (8%)    2/50 (4%)    5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/44.77      2/42.58      6/42.94      2/41.00     |4/45.63      2/46.47      5/46.21      3/43.91      | 
|POLY-3 PERCENT (g) |     13.4%        4.7%         14.0%        4.9%        |8.8%         4.3%         10.8%        6.8%         | 
|TERMINAL (d)       |     3/34 (9%)    0/24 (0%)    2/30 (7%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    1/35 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     222          437          22           512         |595          682          430          254          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.324N     P=0.203N     P=0.547      P=0.189N    |P=0.468      P=0.300N     P=0.507      P=0.519N     | 
|POLY 3             |     P=0.325N     P=0.149N     P=0.592      P=0.162N    |P=0.484      P=0.329N     P=0.508      P=0.521N     | 
|POLY 1.5           |     P=0.313N     P=0.141N     P=0.604      P=0.150N    |P=0.504      P=0.332N     P=0.508      P=0.508N     | 
|POLY 6             |     P=0.339N     P=0.163N     P=0.576      P=0.180N    |P=0.453      P=0.322N     P=0.508      P=0.541N     | 
|LOGISTIC REGRESSION|     P=0.198N     P=0.134N     P=0.439N     P=0.115N    |P=0.554N     P=0.383N     P=0.464      P=0.485N     | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.134N     P=0.620N     P=0.134N    |P=0.521      P=0.339N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.135N     (e)          (e)          (e)         |P=0.533      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/43.82      2/42.63      3/41.17      1/40.35     |1/44.12      1/46.25      0/44.36      1/43.48      | 
|POLY-3 PERCENT (g) |     6.9%         4.7%         7.3%         2.5%        |2.3%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    0/30 (0%)    1/28 (4%)   |1/35 (3%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     622          446          560          729 (T)     |729 (T)      729 (T)      ---          566          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.328N     P=0.556N     P=0.593      P=0.372N    |P=0.603N     P=0.738N     P=0.500N     P=0.750      | 
|POLY 3             |     P=0.328N     P=0.513N     P=0.634      P=0.335N    |P=0.582N     P=0.750N     P=0.499N     P=0.758      | 
|POLY 1.5           |     P=0.315N     P=0.503N     P=0.641      P=0.321N    |P=0.580N     P=0.754N     P=0.499N     P=0.759      | 
|POLY 6             |     P=0.342N     P=0.530N     P=0.626      P=0.356N    |P=0.584N     P=0.743N     P=0.498N     P=0.756      | 
|LOGISTIC REGRESSION|     P=0.266N     P=0.511N     P=0.634N     P=0.321N    |P=0.571N     P=0.738N     (e)          P=0.760N     | 
|COCH-ARM / FISHERS |     P=0.295N     P=0.500N     P=0.661N     P=0.309N    |P=0.579N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.298N     (e)          (e)          (e)         |P=0.538N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  27/50 (54%)  26/50 (52%)  28/50 (56%) |45/50 (90%)  47/50 (94%)  46/50 (92%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |     31/45.64     27/44.37     26/42.23     28/42.75    |45/48.62     47/48.48     46/49.36     45/47.49     | 
|POLY-3 PERCENT (g) |     67.9%        60.9%        61.6%        65.5%       |92.6%        97.0%        93.2%        94.8%        | 
|TERMINAL (d)       |     24/34 (71%)  17/24 (71%)  20/30 (67%)  22/28 (79%) |34/35 (97%)  39/39 (100%) 33/35 (94%)  31/32 (97%)  | 
|FIRST INCIDENCE    |     433          510          402          521         |161          392          430          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.532N     P=0.296      P=0.464N     P=0.399     |P=0.152      P=0.354N     P=0.514      P=0.330      | 
|POLY 3             |     P=0.535      P=0.309N     P=0.339N     P=0.494N    |P=0.572N     P=0.272      P=0.616      P=0.489      | 
|POLY 1.5           |     P=0.480N     P=0.282N     P=0.294N     P=0.419N    |P=0.555N     P=0.300      P=0.559      P=0.506      | 
|POLY 6             |     P=0.457      P=0.352N     P=0.396N     P=0.594N    |P=0.524N     P=0.272      P=0.665N     P=0.551      | 
|LOGISTIC REGRESSION|     P=0.535      P=0.331N     P=0.348N     P=0.507N    |P=0.510N     P=0.434      P=0.514      P=0.599      | 
|COCH-ARM / FISHERS |     P=0.389N     P=0.272N     P=0.210N     P=0.342N    |P=0.422N     P=0.357      P=0.500      P=0.630N     | 
|ORDER RESTRICTED   |     P=0.463N     (e)          (e)          (e)         |P=0.449      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  28/50 (56%)  27/50 (54%)  35/50 (70%) |31/50 (62%)  31/50 (62%)  40/50 (80%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     29/44.86     28/43.28     27/42.53     35/46.10    |31/45.90     31/48.06     40/46.80     36/46.01     | 
|POLY-3 PERCENT (g) |     64.7%        64.7%        63.5%        75.9%       |67.5%        64.5%        85.5%        78.2%        | 
|TERMINAL (d)       |     25/34 (74%)  21/24 (88%)  21/30 (70%)  23/28 (82%) |27/35 (77%)  26/39 (67%)  34/35 (97%)  27/32 (84%)  | 
|FIRST INCIDENCE    |     516          615          402          356         |161          392          430          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.055      P=0.077      P=0.458      P=0.023 *   |P=0.006 **   P=0.326N     P=0.032 *    P=0.087      | 
|POLY 3             |     P=0.115      P=0.590      P=0.545N     P=0.159     |P=0.030 *    P=0.462N     P=0.025 *    P=0.165      | 
|POLY 1.5           |     P=0.109      P=0.539N     P=0.508N     P=0.163     |P=0.040 *    P=0.521N     P=0.029 *    P=0.163      | 
|POLY 6             |     P=0.120      P=0.513      P=0.587N     P=0.145     |P=0.023 *    P=0.367N     P=0.022 *    P=0.188      | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.503      P=0.554      P=0.097     |P=0.040 *    P=0.531N     P=0.034 *    P=0.150      | 
|COCH-ARM / FISHERS |     P=0.103      P=0.500N     P=0.420N     P=0.149     |P=0.074      P=0.582N     P=0.038 *    P=0.198      | 
|ORDER RESTRICTED   |     P=0.158      (e)          (e)          (e)         |P=0.047 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   10/50 (20%)  11/50 (22%) |3/50 (6%)    7/50 (14%)   13/50 (26%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     6/43.34      5/41.92      10/40.82     11/41.52    |3/44.12      7/46.25      13/44.48     14/44.90     | 
|POLY-3 PERCENT (g) |     13.8%        11.9%        24.5%        26.5%       |6.8%         15.1%        29.2%        31.2%        | 
|TERMINAL (d)       |     6/34 (18%)   2/24 (8%)    7/30 (23%)   8/28 (29%)  |3/35 (9%)    7/39 (18%)   12/35 (34%)  9/32 (28%)   | 
|FIRST INCIDENCE    |     729 (T)      641          560          386         |729 (T)      729 (T)      701          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    P=0.551      P=0.141      P=0.068     |P<0.001 **   P=0.203      P=0.006 **   P=0.003 **   | 
|POLY 3             |     P=0.032 *    P=0.524N     P=0.166      P=0.116     |P=0.002 **   P=0.177      P=0.005 **   P=0.003 **   | 
|POLY 1.5           |     P=0.036 *    P=0.509N     P=0.176      P=0.129     |P=0.002 **   P=0.169      P=0.005 **   P=0.003 **   | 
|POLY 6             |     P=0.027 *    P=0.547N     P=0.156      P=0.099     |P<0.001 **   P=0.191      P=0.005 **   P=0.003 **   | 
|LOGISTIC REGRESSION|     P=0.029 *    P=0.580N     P=0.147      P=0.105     |P<0.001 **   P=0.203      P=0.007 **   P=0.004 **   | 
|COCH-ARM / FISHERS |     P=0.043 *    P=0.500N     P=0.207      P=0.143     |P=0.002 **   P=0.159      P=0.006 **   P=0.003 **   | 
|ORDER RESTRICTED   |     P=0.079      (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   2/49 (4%)    2/50 (4%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/43.34      5/42.10      2/39.74      2/40.87     |1/44.44      0/46.25      0/44.36      3/42.25      | 
|POLY-3 PERCENT (g) |     0.0%         11.9%        5.0%         4.9%        |2.3%         0.0%         0.0%         7.1%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          618          560          571         |161          ---          ---          602          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.535N     P=0.022 *    P=0.224      P=0.211     |P=0.058      P=0.500N     P=0.500N     P=0.288      | 
|POLY 3             |     P=0.540N     P=0.028 *    P=0.218      P=0.224     |P=0.057      P=0.492N     P=0.500N     P=0.287      | 
|POLY 1.5           |     P=0.525N     P=0.029 *    P=0.222      P=0.230     |P=0.059      P=0.495N     P=0.499N     P=0.290      | 
|POLY 6             |     P=0.560N     P=0.025 *    P=0.214      P=0.216     |P=0.055      P=0.487N     P=0.500N     P=0.285      | 
|LOGISTIC REGRESSION|     P=0.508N     P=0.031 *    P=0.241      P=0.244     |P=0.067      (e)          (e)          P=0.284      | 
|COCH-ARM / FISHERS |     P=0.506N     P=0.028 *    P=0.242      P=0.247     |P=0.063      P=0.495N     P=0.495N     P=0.301      | 
|ORDER RESTRICTED   |     P=0.100      (e)          (e)          (e)         |P=0.032 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/22 (5%)    0/26 (0%)    1/25 (4%)    2/25 (8%)   |0/13 (0%)    0/13 (0%)    2/9 (22%)    0/21 (0%)    | 
|POLY-3 RATE (b)    |     1/19.98      0/19.88      1/21.41      2/20.87     |0/10.03      0/11.92      2/8.10       0/16.93      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         4.7%         9.6%        |0.0%         0.0%         24.7%        0.0%         | 
|TERMINAL (d)       |     0/15 (0%)    0/10 (0%)    0/16 (0%)    0/11 (0%)   |0/7 (0%)     0/9 (0%)     0/4 (0%)     0/9 (0%)     | 
|FIRST INCIDENCE    |     692          ---          608          512         |---          ---          640          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.173      P=0.534N     P=0.719      P=0.457     |P=0.504      (e)          P=0.254      (e)          | 
|POLY 3             |     P=0.213      P=0.501N     P=0.746N     P=0.515     |P=0.598      (e)          P=0.171      (e)          | 
|POLY 1.5           |     P=0.208      P=0.486N     P=0.743N     P=0.529     |P=0.617      (e)          P=0.165      (e)          | 
|POLY 6             |     P=0.216      P=0.522N     P=0.748N     P=0.494     |P=0.567      (e)          P=0.178      (e)          | 
|LOGISTIC REGRESSION|     P=0.211      P=0.490N     P=0.716N     P=0.643     |P=0.610      (e)          P=0.140      (e)          | 
|COCH-ARM / FISHERS |     P=0.200      P=0.458N     P=0.722N     P=0.549     |P=0.617      (e)          P=0.156      (e)          | 
|ORDER RESTRICTED   |     P=0.237      (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/22 (36%)   8/26 (31%)   13/25 (52%)  14/25 (56%) |7/13 (54%)   4/13 (31%)   3/9 (33%)    5/21 (24%)   | 
|POLY-3 RATE (b)    |     8/19.94      8/21.00      13/22.89     14/21.46    |7/10.78      4/12.10      3/8.00       5/17.81      | 
|POLY-3 PERCENT (g) |     40.1%        38.1%        56.8%        65.2%       |64.9%        33.1%        37.5%        28.1%        | 
|TERMINAL (d)       |     7/15 (47%)   4/10 (40%)   10/16 (63%)  10/11 (91%) |5/7 (71%)    3/9 (33%)    1/4 (25%)    2/9 (22%)    | 
|FIRST INCIDENCE    |     703          618          253          571         |519          682          622          602          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.324      P=0.142      P=0.008 **  |P=0.410N     P=0.122N     P=0.301N     P=0.275N     | 
|POLY 3             |     P=0.024 *    P=0.575N     P=0.214      P=0.085     |P=0.122N     P=0.128N     P=0.230N     P=0.050N     | 
|POLY 1.5           |     P=0.028 *    P=0.525N     P=0.214      P=0.109     |P=0.113N     P=0.149N     P=0.243N     P=0.053N     | 
|POLY 6             |     P=0.019 *    P=0.626      P=0.219      P=0.056     |P=0.146N     P=0.104N     P=0.228N     P=0.050N     | 
|LOGISTIC REGRESSION|     P=0.024 *    P=0.548      P=0.195      P=0.039 *   |P=0.118N     P=0.120N     P=0.241N     P=0.060N     | 
|COCH-ARM / FISHERS |     P=0.034 *    P=0.458N     P=0.217      P=0.146     |P=0.111N     P=0.214N     P=0.305N     P=0.080N     | 
|ORDER RESTRICTED   |     P=0.062      (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/22 (9%)    2/26 (8%)    2/25 (8%)    2/25 (8%)   |2/13 (15%)   4/13 (31%)   2/9 (22%)    3/21 (14%)   | 
|POLY-3 RATE (b)    |     2/19.84      2/19.99      2/20.99      2/20.14     |2/11.02      4/11.96      2/7.81       3/16.93      | 
|POLY-3 PERCENT (g) |     10.1%        10.0%        9.5%         9.9%        |18.2%        33.5%        25.6%        17.7%        | 
|TERMINAL (d)       |     2/15 (13%)   1/10 (10%)   2/16 (13%)   1/11 (9%)   |1/7 (14%)    3/9 (33%)    1/4 (25%)    3/9 (33%)    | 
|FIRST INCIDENCE    |     729 (T)      701          729 (T)      674         |161          720          640          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.551      P=0.561      P=0.677N     P=0.591     |P=0.551N     P=0.423      P=0.601      P=0.595      | 
|POLY 3             |     P=0.578N     P=0.695N     P=0.677N     P=0.693N    |P=0.345N     P=0.362      P=0.570      P=0.681N     | 
|POLY 1.5           |     P=0.572N     P=0.669N     P=0.669N     P=0.673N    |P=0.325N     P=0.344      P=0.567      P=0.669N     | 
|POLY 6             |     P=0.583      P=0.667      P=0.682N     P=0.678     |P=0.389N     P=0.388      P=0.569      P=0.686      | 
|LOGISTIC REGRESSION|     P=0.571      P=0.610      P=0.677N     P=0.655     |P=0.302N     P=0.227      P=0.427      P=0.675      | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.629N     P=0.645N     P=0.645N    |P=0.302N     P=0.322      P=0.550      P=0.647N     | 
|ORDER RESTRICTED   |     P=0.731N     (e)          (e)          (e)         |P=0.468N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  17/50 (34%)  17/50 (34%)  8/50 (16%)  |45/50 (90%)  48/50 (96%)  41/50 (82%)  37/50 (74%)  | 
|POLY-3 RATE (b)    |     15/44.59     17/44.11     17/41.08     8/41.32     |45/48.47     48/48.52     41/47.79     37/48.04     | 
|POLY-3 PERCENT (g) |     33.6%        38.5%        41.4%        19.4%       |92.8%        98.9%        85.8%        77.0%        | 
|TERMINAL (d)       |     10/34 (29%)  9/24 (38%)   13/30 (43%)  5/28 (18%)  |34/35 (97%)  39/39 (100%) 29/35 (83%)  23/32 (72%)  | 
|FIRST INCIDENCE    |     591          446          560          610         |519          509          506          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075N     P=0.164      P=0.266      P=0.186N    |P=0.194N     P=0.430N     P=0.275N     P=0.237N     | 
|POLY 3             |     P=0.065N     P=0.397      P=0.301      P=0.103N    |P<0.001N**   P=0.133      P=0.205N     P=0.024N*    | 
|POLY 1.5           |     P=0.053N     P=0.415      P=0.337      P=0.088N    |P<0.001N**   P=0.175      P=0.183N     P=0.024N*    | 
|POLY 6             |     P=0.084N     P=0.361      P=0.261      P=0.127N    |P<0.001N**   P=0.110      P=0.210N     P=0.023N*    | 
|LOGISTIC REGRESSION|     P=0.056N     P=0.392      P=0.296      P=0.103N    |P=0.002N**   P=0.232      P=0.173N     P=0.036N*    | 
|COCH-ARM / FISHERS |     P=0.041N*    P=0.415      P=0.415      P=0.077N    |P<0.001N**   P=0.218      P=0.194N     P=0.033N*    | 
|ORDER RESTRICTED   |     P=0.046N*    (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      0/39.73      0/40.35     |2/44.58      3/46.25      4/44.36      3/43.52      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         6.5%         9.0%         6.9%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |1/35 (3%)    3/39 (8%)    4/35 (11%)   1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |595          729 (T)      729 (T)      622          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.359      P=0.535      P=0.335      P=0.476      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.401      P=0.517      P=0.335      P=0.489      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.412      P=0.510      P=0.337      P=0.494      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.385      P=0.529      P=0.334      P=0.484      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.410      P=0.506      P=0.339      P=0.504      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.427      P=0.500      P=0.339      P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.411      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia Atypical                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |5/50 (10%)   2/50 (4%)    4/50 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      0/39.73      0/40.35     |5/44.12      2/46.25      4/44.36      4/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |11.3%        4.3%         9.0%         9.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |5/35 (14%)   2/39 (5%)    4/35 (11%)   4/32 (13%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.398      P=0.174N     P=0.500N     P=0.557N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.450      P=0.197N     P=0.497N     P=0.517N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.467      P=0.205N     P=0.497N     P=0.509N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.424      P=0.184N     P=0.492N     P=0.527N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.398      P=0.174N     P=0.500N     P=0.557N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.490      P=0.218N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.415N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/10 (80%)   7/14 (50%)   7/11 (64%)   5/17 (29%)  |9/12 (75%)   12/15 (80%)  14/15 (93%)  6/8 (75%)    | 
|POLY-3 RATE (b)    |     8/10.00      7/10.92      7/9.97       5/12.15     |9/11.57      12/13.59     14/14.68     6/7.37       | 
|POLY-3 PERCENT (g) |     80.0%        64.1%        70.2%        41.1%       |77.8%        88.3%        95.4%        81.4%        | 
|TERMINAL (d)       |     4/6 (67%)    1/2 (50%)    2/3 (67%)    4/7 (57%)   |5/7 (71%)    12/12 (100%) 10/10 (100%) 5/5 (100%)   | 
|FIRST INCIDENCE    |     530          437          560          644         |519          729 (T)      430          580          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.130N     P=0.375      P=0.427      P=0.218N    |P=0.512      P=0.412N     P=0.334      P=0.459N     | 
|POLY 3             |     P=0.053N     P=0.368N     P=0.505N     P=0.054N    |P=0.490      P=0.428      P=0.207      P=0.655      | 
|POLY 1.5           |     P=0.033N*    P=0.250N     P=0.452N     P=0.024N*   |P=0.502      P=0.484      P=0.211      P=0.675      | 
|POLY 6             |     P=0.111N     P=0.533N     P=0.562N     P=0.142N    |P=0.427      P=0.369      P=0.200      P=0.606      | 
|LOGISTIC REGRESSION|     P=0.032N*    P=0.247N     P=0.352N     P=0.049N*   |P=0.514      P=0.693      P=0.217      P=0.687N     | 
|COCH-ARM / FISHERS |     P=0.027N*    P=0.143N     P=0.367N     P=0.015N*   |P=0.490      P=0.557      P=0.216      P=0.693N     | 
|ORDER RESTRICTED   |     P=0.027N*    (e)          (e)          (e)         |P=0.353      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/49 (20%)  8/50 (16%)   10/49 (20%)  8/50 (16%)  |0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     10/43.99     8/41.77      10/39.83     8/40.75     |0/44.12      2/46.25      1/44.36      1/43.19      | 
|POLY-3 PERCENT (g) |     22.7%        19.2%        25.1%        19.6%       |0.0%         4.3%         2.3%         2.3%         | 
|TERMINAL (d)       |     7/34 (21%)   5/24 (21%)   9/30 (30%)   6/28 (21%)  |0/35 (0%)    2/39 (5%)    1/35 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     437          697          521          651         |---          729 (T)      729 (T)      664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.503N     P=0.561      P=0.481      P=0.559N    |P=0.559      P=0.262      P=0.500      P=0.500      | 
|POLY 3             |     P=0.511N     P=0.444N     P=0.501      P=0.467N    |P=0.589      P=0.248      P=0.501      P=0.496      | 
|POLY 1.5           |     P=0.481N     P=0.410N     P=0.533      P=0.427N    |P=0.593      P=0.244      P=0.501      P=0.498      | 
|POLY 6             |     P=0.544      P=0.495N     P=0.463      P=0.519N    |P=0.584      P=0.255      P=0.502      P=0.494      | 
|LOGISTIC REGRESSION|     P=0.507N     P=0.406N     P=0.544      P=0.426N    |P=0.582      P=0.262      P=0.500      P=0.502      | 
|COCH-ARM / FISHERS |     P=0.437N     P=0.379N     P=0.599N     P=0.379N    |P=0.599      P=0.247      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.568N     (e)          (e)          (e)         |P=0.280      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/49 (29%)  13/50 (26%)  14/49 (29%)  14/50 (28%) |2/50 (4%)    3/50 (6%)    4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     14/45.70     13/43.11     14/39.94     14/42.94    |2/45.11      3/46.89      4/44.96      6/43.85      | 
|POLY-3 PERCENT (g) |     30.6%        30.2%        35.1%        32.6%       |4.4%         6.4%         8.9%         13.7%        | 
|TERMINAL (d)       |     7/34 (21%)   7/24 (29%)   12/30 (40%)  6/28 (21%)  |0/35 (0%)    2/39 (5%)    2/35 (6%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     433          471          521          521         |519          520          640          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.411      P=0.427      P=0.437      P=0.418     |P=0.063      P=0.524      P=0.342      P=0.131      | 
|POLY 3             |     P=0.411      P=0.572N     P=0.419      P=0.512     |P=0.071      P=0.518      P=0.335      P=0.123      | 
|POLY 1.5           |     P=0.443      P=0.524N     P=0.478      P=0.555     |P=0.076      P=0.511      P=0.337      P=0.128      | 
|POLY 6             |     P=0.379      P=0.545      P=0.354      P=0.462     |P=0.066      P=0.530      P=0.337      P=0.120      | 
|LOGISTIC REGRESSION|     P=0.468      P=0.468N     P=0.549      P=0.544N    |P=0.092      P=0.429      P=0.315      P=0.138      | 
|COCH-ARM / FISHERS |     P=0.498      P=0.475N     P=0.588N     P=0.563N    |P=0.083      P=0.500      P=0.339      P=0.134      | 
|ORDER RESTRICTED   |     P=0.570      (e)          (e)          (e)         |P=0.089      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |8/50 (16%)   9/50 (18%)   14/50 (28%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |                                                        |8/44.56      9/46.37      14/45.06     8/43.63      | 
|POLY-3 PERCENT (g) |                                                        |18.0%        19.4%        31.1%        18.3%        | 
|TERMINAL (d)       |                                                        |7/35 (20%)   8/39 (21%)   12/35 (34%)  6/32 (19%)   | 
|FIRST INCIDENCE    |                                                        |604          700          519          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.338      P=0.592      P=0.113      P=0.537      | 
|POLY 3             |                                                        |P=0.432      P=0.536      P=0.113      P=0.591      | 
|POLY 1.5           |                                                        |P=0.455      P=0.522      P=0.115      P=0.598      | 
|POLY 6             |                                                        |P=0.399      P=0.562      P=0.115      P=0.582      | 
|LOGISTIC REGRESSION|                                                        |P=0.415      P=0.575      P=0.115      P=0.583      | 
|COCH-ARM / FISHERS |                                                        |P=0.485      P=0.500      P=0.114      P=0.607N     | 
|ORDER RESTRICTED   |                                                        |P=0.347      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/48 (48%)  28/50 (56%)  25/48 (52%)  23/49 (47%) |19/47 (40%)  15/50 (30%)  20/49 (41%)  23/48 (48%)  | 
|POLY-3 RATE (b)    |     23/43.14     28/47.18     25/41.73     23/41.54    |19/43.29     15/47.01     20/45.44     23/45.07     | 
|POLY-3 PERCENT (g) |     53.3%        59.4%        59.9%        55.4%       |43.9%        31.9%        44.0%        51.0%        | 
|TERMINAL (d)       |     19/34 (56%)  13/24 (54%)  18/30 (60%)  18/28 (64%) |15/35 (43%)  13/39 (33%)  15/35 (43%)  14/32 (44%)  | 
|FIRST INCIDENCE    |     530          437          437          570         |519          520          618          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.455N     P=0.036 *    P=0.226      P=0.261     |P=0.039 *    P=0.165N     P=0.508      P=0.207      | 
|POLY 3             |     P=0.532N     P=0.355      P=0.344      P=0.512     |P=0.084      P=0.168N     P=0.581      P=0.322      | 
|POLY 1.5           |     P=0.451N     P=0.337      P=0.358      P=0.567     |P=0.084      P=0.175N     P=0.578      P=0.314      | 
|POLY 6             |     P=0.448      P=0.356      P=0.331      P=0.432     |P=0.084      P=0.155N     P=0.576N     P=0.335      | 
|LOGISTIC REGRESSION|     P=0.402N     P=0.263      P=0.291      P=0.439     |P=0.078      P=0.170N     P=0.571      P=0.293      | 
|COCH-ARM / FISHERS |     P=0.338N     P=0.275      P=0.419      P=0.543N    |P=0.087      P=0.194N     P=0.567      P=0.299      | 
|ORDER RESTRICTED   |     P=0.504      (e)          (e)          (e)         |P=0.157      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    5/50 (10%)   1/48 (2%)    0/49 (0%)   |1/47 (2%)    2/50 (4%)    0/49 (0%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     3/42.09      5/41.50      1/38.61      0/40.00     |1/41.84      2/46.25      0/43.63      2/42.06      | 
|POLY-3 PERCENT (g) |     7.1%         12.1%        2.6%         0.0%        |2.4%         4.3%         0.0%         4.8%         | 
|TERMINAL (d)       |     2/34 (6%)    4/24 (17%)   1/30 (3%)    0/28 (0%)   |1/35 (3%)    2/39 (5%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     703          709          729 (T)      ---         |729 (T)      729 (T)      ---          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.021N*    P=0.200      P=0.357N     P=0.161N    |P=0.491      P=0.538      P=0.500N     P=0.479      | 
|POLY 3             |     P=0.020N*    P=0.348      P=0.336N     P=0.128N    |P=0.529      P=0.535      P=0.492N     P=0.502      | 
|POLY 1.5           |     P=0.019N*    P=0.366      P=0.327N     P=0.121N    |P=0.533      P=0.530      P=0.491N     P=0.505      | 
|POLY 6             |     P=0.023N*    P=0.318      P=0.348N     P=0.137N    |P=0.525      P=0.543      P=0.491N     P=0.498      | 
|LOGISTIC REGRESSION|     P=0.022N*    P=0.267      P=0.350N     P=0.142N    |P=0.517      P=0.538      (e)          P=0.501      | 
|COCH-ARM / FISHERS |     P=0.018N*    P=0.381      P=0.308N     P=0.117N    |P=0.537      P=0.523      P=0.490N     P=0.508      | 
|ORDER RESTRICTED   |     P=0.037N*    (e)          (e)          (e)         |P=0.401      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  14/49 (29%)  13/49 (27%)  9/50 (18%)  |32/50 (64%)  24/50 (48%)  23/50 (46%)  23/49 (47%)  | 
|POLY-3 RATE (b)    |     16/44.66     14/42.23     13/41.29     9/41.56     |32/47.14     24/47.47     23/45.59     23/43.95     | 
|POLY-3 PERCENT (g) |     35.8%        33.2%        31.5%        21.7%       |67.9%        50.6%        50.4%        52.3%        | 
|TERMINAL (d)       |     10/34 (29%)  8/24 (33%)   8/30 (27%)   6/28 (21%)  |24/35 (69%)  19/39 (49%)  18/35 (51%)  18/32 (56%)  | 
|FIRST INCIDENCE    |     591          602          560          512         |519          509          622          602          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.115N     P=0.431      P=0.490N     P=0.205N    |P=0.317N     P=0.039N*    P=0.069N     P=0.138N     | 
|POLY 3             |     P=0.088N     P=0.486N     P=0.422N     P=0.110N    |P=0.187N     P=0.062N     P=0.061N     P=0.090N     | 
|POLY 1.5           |     P=0.078N     P=0.457N     P=0.404N     P=0.094N    |P=0.157N     P=0.066N     P=0.055N     P=0.076N     | 
|POLY 6             |     P=0.105N     P=0.532N     P=0.442N     P=0.138N    |P=0.235N     P=0.054N     P=0.067N     P=0.109N     | 
|LOGISTIC REGRESSION|     P=0.085N     P=0.489N     P=0.419N     P=0.108N    |P=0.162N     P=0.060N     P=0.048N*    P=0.071N     | 
|COCH-ARM / FISHERS |     P=0.067N     P=0.440N     P=0.353N     P=0.083N    |P=0.125N     P=0.079N     P=0.054N     P=0.066N     | 
|ORDER RESTRICTED   |     P=0.111N     (e)          (e)          (e)         |P=0.076N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    5/49 (10%)   1/50 (2%)   |20/50 (40%)  24/50 (48%)  20/50 (40%)  18/49 (37%)  | 
|POLY-3 RATE (b)    |     1/43.34      2/40.65      5/40.26      1/40.35     |20/45.95     24/47.56     20/47.06     18/44.42     | 
|POLY-3 PERCENT (g) |     2.3%         4.9%         12.4%        2.5%        |43.5%        50.5%        42.5%        40.5%        | 
|TERMINAL (d)       |     1/34 (3%)    1/24 (4%)    3/30 (10%)   1/28 (4%)   |15/35 (43%)  20/39 (51%)  13/35 (37%)  13/32 (41%)  | 
|FIRST INCIDENCE    |     729 (T)      721          560          729 (T)     |519          392          430          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.529      P=0.389      P=0.087      P=0.718     |P=0.410N     P=0.448      P=0.563N     P=0.533N     | 
|POLY 3             |     P=0.507      P=0.478      P=0.084      P=0.745     |P=0.258N     P=0.320      P=0.544N     P=0.470N     | 
|POLY 1.5           |     P=0.527      P=0.487      P=0.087      P=0.752     |P=0.244N     P=0.305      P=0.555N     P=0.457N     | 
|POLY 6             |     P=0.481      P=0.463      P=0.082      P=0.734     |P=0.281N     P=0.349      P=0.519N     P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.532      P=0.420      P=0.095      P=0.718     |P=0.243N     P=0.304      P=0.578N     P=0.459N     | 
|COCH-ARM / FISHERS |     P=0.550      P=0.492      P=0.098      P=0.753N    |P=0.229N     P=0.273      P=0.581N     P=0.449N     | 
|ORDER RESTRICTED   |     P=0.235      (e)          (e)          (e)         |P=0.422N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/40.62      0/39.17      2/40.35     |0/44.12      0/46.25      0/44.36      0/42.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    2/28 (7%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.196     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.221     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.229     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.211     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.196     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.044 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.024 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   10/49 (20%)  4/49 (8%)    3/50 (6%)   |11/50 (22%)  9/50 (18%)   8/50 (16%)   6/49 (12%)   | 
|POLY-3 RATE (b)    |     6/43.34      10/41.44     4/39.17      3/40.46     |11/45.08     9/47.24      8/45.06      6/43.74      | 
|POLY-3 PERCENT (g) |     13.8%        24.1%        10.2%        7.4%        |24.4%        19.1%        17.8%        13.7%        | 
|TERMINAL (d)       |     6/34 (18%)   4/24 (17%)   4/30 (13%)   2/28 (7%)   |8/35 (23%)   6/39 (15%)   6/35 (17%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      618          729 (T)      701         |604          520          624          580          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054N     P=0.079      P=0.449N     P=0.344N    |P=0.202N     P=0.315N     P=0.306N     P=0.192N     | 
|POLY 3             |     P=0.050N     P=0.174      P=0.434N     P=0.276N    |P=0.153N     P=0.356N     P=0.303N     P=0.155N     | 
|POLY 1.5           |     P=0.045N*    P=0.186      P=0.418N     P=0.260N    |P=0.145N     P=0.373N     P=0.302N     P=0.154N     | 
|POLY 6             |     P=0.057N     P=0.158      P=0.451N     P=0.298N    |P=0.165N     P=0.327N     P=0.299N     P=0.156N     | 
|LOGISTIC REGRESSION|     P=0.056N     P=0.136      P=0.449N     P=0.334N    |P=0.136N     P=0.393N     P=0.301N     P=0.155N     | 
|COCH-ARM / FISHERS |     P=0.040N*    P=0.194      P=0.383N     P=0.243N    |P=0.134N     P=0.402N     P=0.306N     P=0.154N     | 
|ORDER RESTRICTED   |     P=0.093N     (e)          (e)          (e)         |P=0.156N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    2/49 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.34      1/40.62      2/39.28      0/40.35     |0/44.12      0/46.25      0/44.36      1/43.32      | 
|POLY-3 PERCENT (g) |     0.0%         2.5%         5.1%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      700          ---         |---          ---          ---          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.595N     P=0.431      P=0.217      (e)         |P=0.184      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.601N     P=0.487      P=0.216      (e)         |P=0.179      (e)          (e)          P=0.496      | 
|POLY 1.5           |     P=0.590N     P=0.492      P=0.221      (e)         |P=0.180      (e)          (e)          P=0.497      | 
|POLY 6             |     P=0.616N     P=0.478      P=0.211      (e)         |P=0.176      (e)          (e)          P=0.495      | 
|LOGISTIC REGRESSION|     P=0.604N     P=0.431      P=0.210      (e)         |P=0.169      (e)          (e)          P=0.445      | 
|COCH-ARM / FISHERS |     P=0.576N     P=0.495      P=0.242      (e)         |P=0.181      (e)          (e)          P=0.495      | 
|ORDER RESTRICTED   |     P=0.306      (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   5/50 (10%)   0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/43.48      6/42.90      5/39.73      0/40.35     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         14.0%        12.6%        0.0%        |                                                    | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    5/30 (17%)   0/28 (0%)   |                                                    | 
|FIRST INCIDENCE    |     693          602          729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147N     P=0.046 *    P=0.078      P=0.542N    |                                                    | 
|POLY 3             |     P=0.144N     P=0.053      P=0.081      P=0.515N    |                                                    | 
|POLY 1.5           |     P=0.130N     P=0.055      P=0.088      P=0.508N    |                                                    | 
|POLY 6             |     P=0.164N     P=0.049 *    P=0.074      P=0.525N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.130N     P=0.059      P=0.073      P=0.508N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.119N     P=0.056      P=0.102      P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.063N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     1/43.34      1/41.62      0/39.73      3/40.35     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         2.4%         0.0%         7.4%        |                                                    | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    0/30 (0%)    3/28 (11%)  |                                                    | 
|FIRST INCIDENCE    |     729 (T)      679          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.150      P=0.709      P=0.525N     P=0.237     |                                                    | 
|POLY 3             |     P=0.154      P=0.752      P=0.517N     P=0.280     |                                                    | 
|POLY 1.5           |     P=0.158      P=0.757      P=0.512N     P=0.292     |                                                    | 
|POLY 6             |     P=0.149      P=0.743      P=0.523N     P=0.264     |                                                    | 
|LOGISTIC REGRESSION|     P=0.143      P=0.753      (e)          P=0.237     |                                                    | 
|COCH-ARM / FISHERS |     P=0.167      P=0.753N     P=0.500N     P=0.309     |                                                    | 
|ORDER RESTRICTED   |     P=0.089      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  25/50 (50%)  29/50 (58%)  29/50 (58%) |                                                    | 
|POLY-3 RATE (b)    |     23/45.09     25/45.71     29/46.45     29/45.15    |                                                    | 
|POLY-3 PERCENT (g) |     51.0%        54.7%        62.4%        64.2%       |                                                    | 
|TERMINAL (d)       |     17/34 (50%)  13/24 (54%)  17/30 (57%)  18/28 (64%) |                                                    | 
|FIRST INCIDENCE    |     437          437          253          386         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095      P=0.105      P=0.084      P=0.049 *   |                                                    | 
|POLY 3             |     P=0.095      P=0.443      P=0.182      P=0.138     |                                                    | 
|POLY 1.5           |     P=0.102      P=0.446      P=0.165      P=0.150     |                                                    | 
|POLY 6             |     P=0.089      P=0.423      P=0.202      P=0.123     |                                                    | 
|LOGISTIC REGRESSION|     P=0.105      P=0.402      P=0.141      P=0.125     |                                                    | 
|COCH-ARM / FISHERS |     P=0.115      P=0.421      P=0.158      P=0.158     |                                                    | 
|ORDER RESTRICTED   |     P=0.150      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      0/39.19      0/40.35     |0/44.12      0/46.25      1/44.75      2/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.2%         4.6%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          618          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.054      (e)          P=0.513      P=0.243      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.054      (e)          P=0.503      P=0.234      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.056      (e)          P=0.502      P=0.235      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.052      (e)          P=0.505      P=0.232      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.065      (e)          P=0.477      P=0.240      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.059      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/44.69      2/41.42      4/40.15      1/40.35     |0/44.12      2/46.25      0/44.36      1/43.48      | 
|POLY-3 PERCENT (g) |     9.0%         4.8%         10.0%        2.5%        |0.0%         4.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    2/24 (8%)    3/30 (10%)   1/28 (4%)   |0/35 (0%)    2/39 (5%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     530          729 (T)      608          729 (T)     |---          729 (T)      ---          566          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268N     P=0.434N     P=0.556      P=0.224N    |P=0.631N     P=0.262      (e)          P=0.500      | 
|POLY 3             |     P=0.271N     P=0.372N     P=0.583      P=0.211N    |P=0.602N     P=0.248      (e)          P=0.497      | 
|POLY 1.5           |     P=0.259N     P=0.354N     P=0.604      P=0.196N    |P=0.603N     P=0.244      (e)          P=0.498      | 
|POLY 6             |     P=0.286N     P=0.403N     P=0.559      P=0.233N    |P=0.598N     P=0.255      (e)          P=0.495      | 
|LOGISTIC REGRESSION|     P=0.250N     P=0.334N     P=0.640N     P=0.168N    |P=0.599N     P=0.262      (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.242N     P=0.339N     P=0.643N     P=0.181N    |P=0.606N     P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.175N     (e)          (e)          (e)         |P=0.322      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    3/50 (6%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.34      0/41.42      2/39.73      1/40.35     |1/44.12      3/46.48      3/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.0%         2.5%        |2.3%         6.5%         6.8%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    2/30 (7%)    1/28 (4%)   |1/35 (3%)    2/39 (5%)    3/35 (9%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |729 (T)      669          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189      (e)          P=0.211      P=0.461     |P=0.262N     P=0.356      P=0.305      P=0.518N     | 
|POLY 3             |     P=0.182      (e)          P=0.218      P=0.486     |P=0.234N     P=0.324      P=0.307      P=0.505N     | 
|POLY 1.5           |     P=0.190      (e)          P=0.224      P=0.492     |P=0.227N     P=0.317      P=0.307      P=0.503N     | 
|POLY 6             |     P=0.173      (e)          P=0.211      P=0.477     |P=0.246N     P=0.338      P=0.309      P=0.509N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.211      P=0.461     |P=0.247N     P=0.322      P=0.305      (e)          | 
|COCH-ARM / FISHERS |     P=0.199      (e)          P=0.247      P=0.500     |P=0.219N     P=0.309      P=0.309      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.152      (e)          (e)          (e)         |P=0.168N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/49 (4%)    0/49 (0%)   |0/47 (0%)    3/49 (6%)    1/50 (2%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/43.34      2/42.19      2/39.19      0/39.99     |0/41.84      3/45.37      1/44.36      0/41.81      | 
|POLY-3 PERCENT (g) |     4.6%         4.7%         5.1%         0.0%        |0.0%         6.6%         2.3%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    1/24 (4%)    2/30 (7%)    0/28 (0%)   |0/35 (0%)    2/38 (5%)    1/35 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      446          729 (T)      ---         |---          700          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.167N     P=0.602      P=0.650      P=0.282N    |P=0.239N     P=0.141      P=0.500      (e)          | 
|POLY 3             |     P=0.179N     P=0.685      P=0.658      P=0.255N    |P=0.205N     P=0.134      P=0.512      (e)          | 
|POLY 1.5           |     P=0.173N     P=0.691      P=0.666      P=0.249N    |P=0.203N     P=0.131      P=0.513      (e)          | 
|POLY 6             |     P=0.185N     P=0.671      P=0.648      P=0.265N    |P=0.206N     P=0.138      P=0.511      (e)          | 
|LOGISTIC REGRESSION|     P=0.167N     P=0.693N     P=0.650      (e)         |P=0.222N     P=0.137      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.164N     P=0.691N     P=0.684      P=0.253N    |P=0.205N     P=0.129      P=0.515      (e)          | 
|ORDER RESTRICTED   |     P=0.188N     (e)          (e)          (e)         |P=0.238N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    7/49 (14%)   5/49 (10%)  |5/47 (11%)   16/49 (33%)  7/50 (14%)   5/48 (10%)   | 
|POLY-3 RATE (b)    |     2/43.34      4/42.07      7/42.46      5/42.24     |5/41.95      16/47.21     7/45.25      5/42.55      | 
|POLY-3 PERCENT (g) |     4.6%         9.5%         16.5%        11.8%       |11.9%        33.9%        15.5%        11.8%        | 
|TERMINAL (d)       |     2/34 (6%)    1/24 (4%)    2/30 (7%)    0/28 (0%)   |4/35 (11%)   11/38 (29%)  5/35 (14%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      618          253          514         |701          392          441          580          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.161      P=0.239      P=0.070      P=0.181     |P=0.112N     P=0.016 *    P=0.387      P=0.579      | 
|POLY 3             |     P=0.173      P=0.323      P=0.073      P=0.205     |P=0.058N     P=0.012 *    P=0.433      P=0.622N     | 
|POLY 1.5           |     P=0.173      P=0.332      P=0.073      P=0.207     |P=0.056N     P=0.010 *    P=0.432      P=0.619N     | 
|POLY 6             |     P=0.175      P=0.308      P=0.072      P=0.202     |P=0.062N     P=0.016 *    P=0.434      P=0.626N     | 
|LOGISTIC REGRESSION|     P=0.200      P=0.319      P=0.111      P=0.221     |P=0.058N     P=0.009 **   P=0.424      P=0.627N     | 
|COCH-ARM / FISHERS |     P=0.172      P=0.339      P=0.075      P=0.210     |P=0.059N     P=0.008 **   P=0.424      P=0.616N     | 
|ORDER RESTRICTED   |     P=0.112      (e)          (e)          (e)         |P=0.126N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/49 (4%)    2/49 (4%)   |0/47 (0%)    2/49 (4%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/43.34      2/41.42      2/39.19      2/40.63     |0/41.84      2/45.37      0/44.36      0/41.81      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         5.1%         4.9%        |0.0%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    2/24 (8%)    2/30 (7%)    0/28 (0%)   |0/35 (0%)    1/38 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      631         |---          700          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276      P=0.165      P=0.211      P=0.220     |P=0.251N     P=0.263      (e)          (e)          | 
|POLY 3             |     P=0.270      P=0.227      P=0.215      P=0.223     |P=0.219N     P=0.255      (e)          (e)          | 
|POLY 1.5           |     P=0.278      P=0.233      P=0.220      P=0.227     |P=0.220N     P=0.252      (e)          (e)          | 
|POLY 6             |     P=0.261      P=0.217      P=0.210      P=0.217     |P=0.217N     P=0.261      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.272      P=0.165      P=0.211      P=0.239     |P=0.231N     P=0.254      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.287      P=0.247      P=0.242      P=0.242     |P=0.224N     P=0.258      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.168      (e)          (e)          (e)         |P=0.263N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    4/49 (8%)    0/49 (0%)   |8/47 (17%)   9/49 (18%)   6/50 (12%)   1/48 (2%)    | 
|POLY-3 RATE (b)    |     4/43.70      1/41.46      4/40.05      0/39.99     |8/43.29      9/45.47      6/45.77      1/42.10      | 
|POLY-3 PERCENT (g) |     9.2%         2.4%         10.0%        0.0%        |18.5%        19.8%        13.1%        2.4%         | 
|TERMINAL (d)       |     3/34 (9%)    0/24 (0%)    2/30 (7%)    0/28 (0%)   |5/35 (14%)   7/38 (18%)   2/35 (6%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          721          602          ---         |519          682          506          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179N     P=0.274N     P=0.557      P=0.088N    |P=0.014N*    P=0.567      P=0.390N     P=0.026N*    | 
|POLY 3             |     P=0.174N     P=0.194N     P=0.595      P=0.072N    |P=0.007N**   P=0.545      P=0.343N     P=0.017N*    | 
|POLY 1.5           |     P=0.170N     P=0.185N     P=0.605      P=0.067N    |P=0.006N**   P=0.544      P=0.340N     P=0.016N*    | 
|POLY 6             |     P=0.178N     P=0.210N     P=0.586      P=0.079N    |P=0.008N**   P=0.552      P=0.344N     P=0.019N*    | 
|LOGISTIC REGRESSION|     P=0.173N     P=0.197N     P=0.614      P=0.072N    |P=0.006N**   P=0.541      P=0.350N     P=0.016N*    | 
|COCH-ARM / FISHERS |     P=0.164N     P=0.181N     P=0.631      P=0.061N    |P=0.006N**   P=0.538      P=0.339N     P=0.014N*    | 
|ORDER RESTRICTED   |     P=0.043N*    (e)          (e)          (e)         |P=0.016N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/49 (10%)   5/49 (10%)   2/50 (4%)   |2/50 (4%)    5/50 (10%)   0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.88      5/42.11      5/40.34      2/40.72     |2/45.11      5/47.01      0/44.36      1/43.24      | 
|POLY-3 PERCENT (g) |     4.6%         11.9%        12.4%        4.9%        |4.4%         10.6%        0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    3/39 (8%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     616          471          607          624         |519          520          ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443N     P=0.184      P=0.163      P=0.640     |P=0.095N     P=0.254      P=0.244N     P=0.502N     | 
|POLY 3             |     P=0.432N     P=0.199      P=0.182      P=0.667     |P=0.078N     P=0.233      P=0.241N     P=0.515N     | 
|POLY 1.5           |     P=0.410N     P=0.206      P=0.189      P=0.680     |P=0.076N     P=0.227      P=0.239N     P=0.508N     | 
|POLY 6             |     P=0.460N     P=0.187      P=0.177      P=0.649     |P=0.081N     P=0.245      P=0.242N     P=0.523N     | 
|LOGISTIC REGRESSION|     P=0.368N     P=0.207      P=0.212      P=0.690N    |P=0.068N     P=0.174      P=0.274N     P=0.499N     | 
|COCH-ARM / FISHERS |     P=0.381N     P=0.210      P=0.210      P=0.691N    |P=0.076N     P=0.218      P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.306      (e)          (e)          (e)         |P=0.107N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/49 (8%)    3/49 (6%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.34      4/41.70      3/39.85      1/40.77     |1/44.47      1/46.91      0/44.36      1/43.19      | 
|POLY-3 PERCENT (g) |     0.0%         9.6%         7.5%         2.5%        |2.3%         2.1%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          612          560          610         |633          509          ---          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.054      P=0.107      P=0.486     |P=0.596N     P=0.750N     P=0.500N     P=0.758      | 
|POLY 3             |     P=0.479N     P=0.055      P=0.104      P=0.488     |P=0.584N     P=0.749N     P=0.500N     P=0.754      | 
|POLY 1.5           |     P=0.463N     P=0.057      P=0.107      P=0.494     |P=0.581N     P=0.753N     P=0.500N     P=0.757      | 
|POLY 6             |     P=0.499N     P=0.052      P=0.101      P=0.480     |P=0.589N     P=0.741N     P=0.500N     P=0.751      | 
|LOGISTIC REGRESSION|     P=0.432N     P=0.060      P=0.117      P=0.509     |P=0.559N     P=0.705      P=0.517N     P=0.760N     | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.056      P=0.117      P=0.500     |P=0.579N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.120      (e)          (e)          (e)         |P=0.542N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/49 (10%)   5/49 (10%)   3/50 (6%)   |3/50 (6%)    5/50 (10%)   0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.77      5/42.32      5/40.66      3/40.75     |3/45.41      5/46.41      0/44.36      1/43.24      | 
|POLY-3 PERCENT (g) |     4.6%         11.8%        12.3%        7.4%        |6.6%         10.8%        0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    1/24 (4%)    1/30 (3%)    1/28 (4%)   |0/35 (0%)    3/39 (8%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          471          602          624         |519          700          ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.536      P=0.172      P=0.163      P=0.436     |P=0.062N     P=0.417      P=0.124N     P=0.310N     | 
|POLY 3             |     P=0.533      P=0.202      P=0.186      P=0.467     |P=0.049N*    P=0.368      P=0.123N     P=0.323N     | 
|POLY 1.5           |     P=0.556      P=0.208      P=0.191      P=0.483     |P=0.047N*    P=0.364      P=0.121N     P=0.315N     | 
|POLY 6             |     P=0.503      P=0.190      P=0.183      P=0.447     |P=0.052N     P=0.379      P=0.125N     P=0.333N     | 
|LOGISTIC REGRESSION|     P=0.527N     P=0.204      P=0.219      P=0.492     |P=0.043N*    P=0.330      P=0.137N     P=0.298N     | 
|COCH-ARM / FISHERS |     P=0.545N     P=0.210      P=0.210      P=0.500     |P=0.047N*    P=0.357      P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.269      (e)          (e)          (e)         |P=0.076N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/49 (10%)   5/49 (10%)   1/50 (2%)   |0/50 (0%)    6/50 (12%)   0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     7/45.74      5/41.96      5/40.46      1/40.77     |0/44.12      6/46.93      0/44.36      2/43.19      | 
|POLY-3 PERCENT (g) |     15.3%        11.9%        12.4%        2.5%        |0.0%         12.8%        0.0%         4.6%         | 
|TERMINAL (d)       |     1/34 (3%)    0/24 (0%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    4/39 (10%)   0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     222          446          560          610         |---          520          ---          664          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.055N     P=0.480N     P=0.483N     P=0.054N    |P=0.361N     P=0.025 *    (e)          P=0.230      | 
|POLY 3             |     P=0.046N*    P=0.441N     P=0.467N     P=0.044N*   |P=0.300N     P=0.019 *    (e)          P=0.232      | 
|POLY 1.5           |     P=0.041N*    P=0.419N     P=0.447N     P=0.038N*   |P=0.302N     P=0.017 *    (e)          P=0.235      | 
|POLY 6             |     P=0.053N     P=0.476N     P=0.488N     P=0.053N    |P=0.296N     P=0.021 *    (e)          P=0.230      | 
|LOGISTIC REGRESSION|     P=0.025N*    P=0.388N     P=0.326N     P=0.023N*   |P=0.312N     P=0.017 *    (e)          P=0.235      | 
|COCH-ARM / FISHERS |     P=0.034N*    P=0.394N     P=0.394N     P=0.030N*   |P=0.311N     P=0.013 *    (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.035N*    (e)          (e)          (e)         |P=0.135      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    5/48 (10%)   3/48 (6%)    1/50 (2%)   |1/49 (2%)    2/50 (4%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      5/42.40      3/39.85      1/40.35     |1/43.45      2/46.25      0/44.36      2/42.76      | 
|POLY-3 PERCENT (g) |     0.0%         11.8%        7.5%         2.5%        |2.3%         4.3%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    1/28 (4%)   |1/35 (3%)    2/39 (5%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          446          560          729 (T)     |729 (T)      729 (T)      ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.375N     P=0.031 *    P=0.111      P=0.461     |P=0.496      P=0.538      P=0.500N     P=0.489      | 
|POLY 3             |     P=0.371N     P=0.028 *    P=0.104      P=0.486     |P=0.529      P=0.522      P=0.496N     P=0.494      | 
|POLY 1.5           |     P=0.353N     P=0.029 *    P=0.105      P=0.492     |P=0.532      P=0.516      P=0.495N     P=0.497      | 
|POLY 6             |     P=0.396N     P=0.027 *    P=0.103      P=0.477     |P=0.525      P=0.532      P=0.495N     P=0.492      | 
|LOGISTIC REGRESSION|     P=0.291N     P=0.017 *    P=0.131      P=0.461     |P=0.528      P=0.538      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.335N     P=0.025 *    P=0.114      P=0.500     |P=0.537      P=0.508      P=0.495N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.101      (e)          (e)          (e)         |P=0.397      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    6/48 (13%)   4/48 (8%)    1/50 (2%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      6/41.09      4/40.45      1/40.72     |0/43.45      1/46.91      0/44.36      2/42.47      | 
|POLY-3 PERCENT (g) |     0.0%         14.6%        9.9%         2.5%        |0.0%         2.1%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/34 (0%)    2/24 (8%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          446          437          624         |---          509          ---          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.326N     P=0.010 *    P=0.059      P=0.485     |P=0.161      P=0.500      (e)          P=0.227      | 
|POLY 3             |     P=0.319N     P=0.012 *    P=0.051      P=0.488     |P=0.172      P=0.515      (e)          P=0.232      | 
|POLY 1.5           |     P=0.303N     P=0.013 *    P=0.052      P=0.493     |P=0.175      P=0.511      (e)          P=0.234      | 
|POLY 6             |     P=0.341N     P=0.011 *    P=0.051      P=0.480     |P=0.170      P=0.522      (e)          P=0.229      | 
|LOGISTIC REGRESSION|     P=0.260N     P=0.016 *    P=0.076      P=0.509     |P=0.190      P=0.397      (e)          P=0.233      | 
|COCH-ARM / FISHERS |     P=0.286N     P=0.012 *    P=0.054      P=0.500     |P=0.177      P=0.505      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.066      (e)          (e)          (e)         |P=0.071      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/48 (6%)    4/48 (8%)    2/50 (4%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/43.34      3/40.62      4/39.85      2/40.69     |0/43.45      1/46.25      0/44.36      2/42.76      | 
|POLY-3 PERCENT (g) |     0.0%         7.4%         10.0%        4.9%        |0.0%         2.2%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    1/30 (3%)    0/28 (0%)   |0/35 (0%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          641          560          644         |---          729 (T)      ---          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.323      P=0.106      P=0.055      P=0.211     |P=0.158      P=0.522      (e)          P=0.240      | 
|POLY 3             |     P=0.331      P=0.107      P=0.050      P=0.223     |P=0.174      P=0.512      (e)          P=0.233      | 
|POLY 1.5           |     P=0.349      P=0.110      P=0.051      P=0.230     |P=0.175      P=0.509      (e)          P=0.235      | 
|POLY 6             |     P=0.309      P=0.103      P=0.049 *    P=0.215     |P=0.172      P=0.518      (e)          P=0.232      | 
|LOGISTIC REGRESSION|     P=0.378      P=0.114      P=0.063      P=0.233     |P=0.179      P=0.522      (e)          P=0.240      | 
|COCH-ARM / FISHERS |     P=0.371      P=0.114      P=0.054      P=0.247     |P=0.177      P=0.505      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.098      (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  24/50 (48%)  13/49 (27%)  10/50 (20%) |                                                    | 
|POLY-3 RATE (b)    |     11/44.52     24/43.08     13/41.85     10/42.31    |                                                    | 
|POLY-3 PERCENT (g) |     24.7%        55.7%        31.1%        23.6%       |                                                    | 
|TERMINAL (d)       |     9/34 (27%)   15/24 (63%)  6/30 (20%)   6/28 (21%)  |                                                    | 
|FIRST INCIDENCE    |     433          615          402          512         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.075N     P<0.001 **   P=0.293      P=0.538     |                                                    | 
|POLY 3             |     P=0.046N*    P=0.002 **   P=0.337      P=0.553N    |                                                    | 
|POLY 1.5           |     P=0.043N*    P=0.003 **   P=0.346      P=0.529N    |                                                    | 
|POLY 6             |     P=0.051N     P<0.001 **   P=0.336      P=0.583N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.052N     P=0.003 **   P=0.367      P=0.512N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.042N*    P=0.006 **   P=0.385      P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.068N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   4/49 (8%)    4/50 (8%)   |                                                    | 
|POLY-3 RATE (b)    |     1/43.52      5/43.84      4/40.23      4/43.24     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         11.4%        9.9%         9.3%        |                                                    | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    2/30 (7%)    0/28 (0%)   |                                                    | 
|FIRST INCIDENCE    |     682          471          560          356         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318      P=0.102      P=0.154      P=0.167     |                                                    | 
|POLY 3             |     P=0.335      P=0.102      P=0.155      P=0.176     |                                                    | 
|POLY 1.5           |     P=0.343      P=0.104      P=0.160      P=0.180     |                                                    | 
|POLY 6             |     P=0.319      P=0.098      P=0.151      P=0.168     |                                                    | 
|LOGISTIC REGRESSION|     P=0.413      P=0.084      P=0.178      P=0.170     |                                                    | 
|COCH-ARM / FISHERS |     P=0.345      P=0.102      P=0.175      P=0.181     |                                                    | 
|ORDER RESTRICTED   |     P=0.136      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/48 (0%)    2/50 (4%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.34      0/39.44      0/38.63      2/40.35     |0/43.55      0/45.89      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/33 (0%)    0/23 (0%)    0/30 (0%)    2/28 (7%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    (e)          (e)          P=0.202     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.042 *    (e)          (e)          P=0.226     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.234     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.041 *    (e)          (e)          P=0.217     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.202     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.026 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/48 (4%)    3/48 (6%)    2/50 (4%)   |2/49 (4%)    0/49 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.70      2/40.64      3/40.69      2/41.85     |2/44.35      0/45.89      1/45.16      0/42.95      | 
|POLY-3 PERCENT (g) |     2.3%         4.9%         7.4%         4.8%        |4.5%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/33 (0%)    0/23 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          437          423          386         |595          ---          430          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.387      P=0.494      P=0.273      P=0.486     |P=0.287N     P=0.234N     P=0.503N     P=0.250N     | 
|POLY 3             |     P=0.406      P=0.483      P=0.288      P=0.493     |P=0.290N     P=0.230N     P=0.494N     P=0.244N     | 
|POLY 1.5           |     P=0.415      P=0.490      P=0.289      P=0.501     |P=0.282N     P=0.232N     P=0.492N     P=0.239N     | 
|POLY 6             |     P=0.392      P=0.469      P=0.286      P=0.480     |P=0.307N     P=0.225N     P=0.496N     P=0.252N     | 
|LOGISTIC REGRESSION|     P=0.493      P=0.444      P=0.401      P=0.502     |P=0.248N     P=0.279N     P=0.573N     P=0.229N     | 
|COCH-ARM / FISHERS |     P=0.424      P=0.492      P=0.301      P=0.508     |P=0.271N     P=0.247N     P=0.492N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.336      (e)          (e)          (e)         |P=0.079N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   0/50 (0%)    2/49 (4%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     5/43.34      0/41.42      2/39.63      3/40.77     |1/44.12      0/46.25      0/44.36      0/42.28      | 
|POLY-3 PERCENT (g) |     11.5%        0.0%         5.1%         7.4%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/34 (15%)   0/24 (0%)    1/30 (3%)    2/28 (7%)   |1/35 (3%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          602          610         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.513      P=0.070N     P=0.271N     P=0.458N    |P=0.386N     P=0.478N     P=0.500N     P=0.518N     | 
|POLY 3             |     P=0.527      P=0.034N*    P=0.253N     P=0.390N    |P=0.375N     P=0.491N     P=0.499N     P=0.509N     | 
|POLY 1.5           |     P=0.529      P=0.032N*    P=0.245N     P=0.374N    |P=0.373N     P=0.494N     P=0.499N     P=0.507N     | 
|POLY 6             |     P=0.531      P=0.038N*    P=0.260N     P=0.411N    |P=0.380N     P=0.484N     P=0.498N     P=0.511N     | 
|LOGISTIC REGRESSION|     P=0.505      (e)          P=0.262N     P=0.422N    |P=0.386N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.538      P=0.028N*    P=0.226N     P=0.357N    |P=0.369N     P=0.500N     P=0.500N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.111N     (e)          (e)          (e)         |P=0.129N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   13/50 (26%)  15/49 (31%)  4/50 (8%)   |23/50 (46%)  6/50 (12%)   18/50 (36%)  18/49 (37%)  | 
|POLY-3 RATE (b)    |     9/43.34      13/43.72     15/41.29     4/40.89     |23/44.47     6/46.44      18/45.61     18/43.58     | 
|POLY-3 PERCENT (g) |     20.8%        29.7%        36.3%        9.8%        |51.7%        12.9%        39.5%        41.3%        | 
|TERMINAL (d)       |     9/34 (27%)   7/24 (29%)   10/30 (33%)  2/28 (7%)   |22/35 (63%)  5/39 (13%)   14/35 (40%)  14/32 (44%)  | 
|FIRST INCIDENCE    |     729 (T)      446          402          633         |632          682          622          580          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095N     P=0.079      P=0.067      P=0.202N    |P=0.107      P<0.001N**   P=0.198N     P=0.311N     | 
|POLY 3             |     P=0.089N     P=0.236      P=0.086      P=0.136N    |P=0.166      P<0.001N**   P=0.165N     P=0.217N     | 
|POLY 1.5           |     P=0.077N     P=0.240      P=0.090      P=0.126N    |P=0.183      P<0.001N**   P=0.181N     P=0.224N     | 
|POLY 6             |     P=0.104N     P=0.225      P=0.084      P=0.149N    |P=0.144      P<0.001N**   P=0.137N     P=0.202N     | 
|LOGISTIC REGRESSION|     P=0.080N     P=0.211      P=0.075      P=0.171N    |P=0.149      P<0.001N**   P=0.180N     P=0.267N     | 
|COCH-ARM / FISHERS |     P=0.067N     P=0.235      P=0.109      P=0.117N    |P=0.219      P<0.001N**   P=0.208N     P=0.232N     | 
|ORDER RESTRICTED   |     P=0.025N*    (e)          (e)          (e)         |P=0.024N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    2/49 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/43.41      2/41.57      2/39.19      2/40.38     |0/44.12      0/46.25      0/44.36      0/42.28      | 
|POLY-3 PERCENT (g) |     9.2%         4.8%         5.1%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/34 (9%)    0/24 (0%)    2/30 (7%)    1/28 (4%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     711          701          729 (T)      723         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.361N     P=0.482N     P=0.399N     P=0.427N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.361N     P=0.357N     P=0.385N     P=0.371N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.354N     P=0.345N     P=0.373N     P=0.355N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.369N     P=0.377N     P=0.398N     P=0.393N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.384N     P=0.401N     P=0.401N     P=0.419N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.339N     P=0.339N     P=0.349N     P=0.339N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.328N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.34      2/42.52      0/39.73      0/40.35     |0/44.12      0/46.25      1/44.69      0/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         0.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/24 (0%)    0/30 (0%)    0/28 (0%)   |0/35 (0%)    0/39 (0%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          446          ---          ---         |---          ---          640          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241N     P=0.242      (e)          (e)         |P=0.623      (e)          P=0.505      (e)          | 
|POLY 3             |     P=0.239N     P=0.233      (e)          (e)         |P=0.609      (e)          P=0.503      (e)          | 
|POLY 1.5           |     P=0.233N     P=0.236      (e)          (e)         |P=0.620      (e)          P=0.502      (e)          | 
|POLY 6             |     P=0.248N     P=0.225      (e)          (e)         |P=0.598      (e)          P=0.505      (e)          | 
|LOGISTIC REGRESSION|     P=0.193N     P=0.180      (e)          (e)         |P=0.640      (e)          P=0.486      (e)          | 
|COCH-ARM / FISHERS |     P=0.227N     P=0.247      (e)          (e)         |P=0.634      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.257N     (e)          (e)          (e)         |P=0.383      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |3/44.12      0/46.25      1/44.36      3/43.24      | 
|POLY-3 PERCENT (g) |                                                        |6.8%         0.0%         2.3%         6.9%         | 
|TERMINAL (d)       |                                                        |3/35 (9%)    0/39 (0%)    1/35 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.254      P=0.102N     P=0.305N     P=0.630      | 
|POLY 3             |                                                        |P=0.281      P=0.110N     P=0.303N     P=0.653      | 
|POLY 1.5           |                                                        |P=0.291      P=0.114N     P=0.303N     P=0.657      | 
|POLY 6             |                                                        |P=0.267      P=0.105N     P=0.300N     P=0.649      | 
|LOGISTIC REGRESSION|                                                        |P=0.271      (e)          P=0.305N     P=0.643      | 
|COCH-ARM / FISHERS |                                                        |P=0.304      P=0.121N     P=0.309N     P=0.661N     | 
|ORDER RESTRICTED   |                                                        |P=0.273      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.12      2/46.25      1/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         4.3%         2.3%         0.0%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    2/39 (5%)    1/35 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.218N     P=0.538      P=0.762      P=0.518N     | 
|POLY 3             |                                                        |P=0.198N     P=0.516      P=0.760N     P=0.505N     | 
|POLY 1.5           |                                                        |P=0.195N     P=0.510      P=0.759N     P=0.503N     | 
|POLY 6             |                                                        |P=0.203N     P=0.528      P=0.758N     P=0.509N     | 
|LOGISTIC REGRESSION|                                                        |P=0.218N     P=0.538      P=0.762      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.191N     P=0.500      P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.241N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.12      0/46.25      1/44.36      2/42.95      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         2.3%         4.7%         | 
|TERMINAL (d)       |                                                        |0/35 (0%)    0/39 (0%)    1/35 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.045 *    (e)          P=0.500      P=0.219      | 
|POLY 3             |                                                        |P=0.053      (e)          P=0.501      P=0.231      | 
|POLY 1.5           |                                                        |P=0.055      (e)          P=0.501      P=0.234      | 
|POLY 6             |                                                        |P=0.050      (e)          P=0.502      P=0.227      | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.500      P=0.219      | 
|COCH-ARM / FISHERS |                                                        |P=0.059      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |                                                        |P=0.070      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/44.12      1/46.25      0/44.36      0/42.95      | 
|POLY-3 PERCENT (g) |                                                        |4.5%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |2/35 (6%)    1/39 (3%)    0/35 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.121N     P=0.462N     P=0.238N     P=0.258N     | 
|POLY 3             |                                                        |P=0.111N     P=0.484N     P=0.236N     P=0.243N     | 
|POLY 1.5           |                                                        |P=0.110N     P=0.490N     P=0.236N     P=0.240N     | 
|POLY 6             |                                                        |P=0.115N     P=0.472N     P=0.234N     P=0.246N     | 
|LOGISTIC REGRESSION|                                                        |P=0.121N     P=0.462N     (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.107N     P=0.500N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |                                                        |P=0.078N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/14/04                           EXPERIMENT: 96017 TEST: 05                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Vagina                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/1 (0%)     0/4 (0%)     3/6 (50%)    10/20 (50%)  | 
|POLY-3 RATE (b)    |                                                        |0/0.66       0/2.07       3/5.36       10/18.85     | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         56.0%        53.1%        | 
|TERMINAL (d)       |                                                        |0/0 (0%)     0/1 (0%)     2/4 (50%)    8/14 (57%)   | 
|FIRST INCIDENCE    |                                                        |---          ---          657          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.035 *    (e)          P=0.510      P=0.236      | 
|POLY 3             |                                                        |P=0.288      (e)          P=0.645      P=0.635      | 
|POLY 1.5           |                                                        |P=0.165      (e)          P=0.600      P=0.581      | 
|POLY 6             |                                                        |P=0.471      (e)          P=0.719      P=0.720      | 
|LOGISTIC REGRESSION|                                                        |P=0.229      (e)          P=0.711      P=0.655      | 
|COCH-ARM / FISHERS |                                                        |P=0.065      (e)          P=0.571      P=0.524      | 
|ORDER RESTRICTED   |                                                        |P=0.609      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Vagina                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/1 (0%)     1/4 (25%)    1/6 (17%)    9/20 (45%)   | 
|POLY-3 RATE (b)    |                                                        |0/0.66       1/2.70       1/5.09       9/19.32      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         37.0%        19.6%        46.6%        | 
|TERMINAL (d)       |                                                        |0/0 (0%)     0/1 (0%)     1/4 (25%)    5/14 (36%)   | 
|FIRST INCIDENCE    |                                                        |---          521          729 (T)      622          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.013 *    P=0.496      P=1.000      P=0.065      | 
|POLY 3             |                                                        |P=0.265      P=0.778      P=0.852      P=0.663      | 
|POLY 1.5           |                                                        |P=0.207      P=0.761      P=0.840      P=0.615      | 
|POLY 6             |                                                        |P=0.349      P=0.816      P=0.870      P=0.732      | 
|LOGISTIC REGRESSION|                                                        |P=0.107      (e)          P=1.000      P=0.489      | 
|COCH-ARM / FISHERS |                                                        |P=0.137      P=0.800      P=0.857      P=0.571      | 
|ORDER RESTRICTED   |                                                        |P=0.631      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.