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TDMS Study 96017-05 Pathology Tables

NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24

                                                          FINAL#1 RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  631-64-1

       Lock Date:  11/15/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     11            6            6            4                                     
    Moribund Sacrifice                                 4            5            9           14                                     
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                35           38           34           32                                     
    Moribund Sacrifice                                              1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (49)         (49)         (48)                                   
      Edema                                                                                   2 [1.5]                               
      Inflammation                                                                            1 [1.0]                               
   Intestine Large, Rectum                            (49)         (50)         (50)         (48)                                   
      Inflammation                                                  1 [2.0]                                                         
   Intestine Small, Ileum                             (44)         (47)         (45)         (48)                                   
      Inflammation, Suppurative                                                  1 [3.0]                                            
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                36           41           29           15                                     
      Clear Cell Focus                                 8            4           14           18                                     
      Degeneration, Cystic                                                                    1 [2.0]                               
      Eosinophilic Focus                               4            4            5            9                                     
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Hepatodiaphragmatic Nodule                       3 [1.0]      9 [1.4]      2 [1.0]      5 [1.0]                               
      Inflammation, Chronic                            2 [1.5]      3 [1.7]      3 [1.0]      1 [1.0]                               
      Inflammation, Granulomatous                      8 [1.3]                   1 [1.0]      2 [1.0]                               
      Mixed Cell Focus                                 1            1            1            4                                     
      Necrosis, Focal                                  1 [2.0]                                1 [1.0]                               
      Bile Duct, Hyperplasia                          17 [1.5]     15 [1.5]     15 [1.7]     19 [1.6]                               
      Centrilobular, Necrosis                          1 [1.0]      1 [1.0]                   1 [2.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            3 [1.7]      2 [2.5]                   1 [3.0]                               
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    1 [2.0]                                                                      
      Serosa, Fibrosis                                 2 [1.0]      2 [1.0]                                                         
   Mesentery                                          (12)         (15)         (15)         (8)                                    
      Accessory Spleen                                 1 [1.0]                   1 [1.0]                                            
      Fat, Necrosis                                    9 [2.1]     12 [2.2]     14 [2.2]      6 [2.0]                               
   Pancreas                                           (47)         (50)         (49)         (48)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                         19 [1.4]     15 [1.4]     20 [1.4]     23 [1.2]                               
      Cyst                                             1 [1.0]                   1 [1.0]      1 [1.0]                               
      Acinus, Hyperplasia, Focal                       1 [1.0]      2 [1.5]                   2 [1.0]                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Inflammation                                                               1 [2.0]      2 [2.0]                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            2 [1.5]      5 [1.4]                   1 [2.0]                               
      Erosion                                          1 [1.0]      1 [1.0]                   1 [1.0]                               
      Ulcer                                            3 [1.7]      5 [2.6]                   1 [2.0]                               
      Epithelium, Hyperplasia                                       6 [2.0]                   2 [1.0]                               
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
      Edema                                            1 [1.0]      2 [2.0]                   2 [1.5]                               
      Erosion                                                       1 [3.0]                   2 [1.5]                               
      Ulcer                                                         1 [2.0]                   2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  37 [1.2]     29 [1.1]     34 [1.3]     35 [1.1]                               
      Mineralization                                   1 [1.0]                                                                      
      Thrombosis                                       2 [2.5]      1 [3.0]      1 [3.0]      1 [3.0]                               
      Valve, Inflammation, Suppurative                                                        1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule               17 [1.1]      8 [1.0]      6 [1.0]      6 [1.0]                               
      Degeneration, Fatty                             14 [1.4]     19 [1.4]     15 [1.2]     14 [1.6]                               
      Hyperplasia, Focal                               8 [1.0]      6 [1.0]      4 [1.5]      5 [1.0]                               
      Hypertrophy, Focal                              18 [1.3]     19 [1.6]     21 [1.3]     17 [1.5]                               
      Necrosis                                         3 [2.3]      1 [1.0]      1 [2.0]      1 [3.0]                               
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Hyperplasia                                      5 [1.2]      1 [3.0]      2 [1.0]      4 [2.0]                               
   Islets, Pancreatic                                 (47)         (49)         (49)         (48)                                   
      Metaplasia, Hepatocyte                                        1 [1.0]                   3 [2.7]                               
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Pars Distalis, Angiectasis                      32 [1.5]     24 [2.0]     23 [1.9]     23 [1.7]                               
      Pars Distalis, Cyst                             20 [1.2]     24 [1.4]     20 [1.4]     18 [1.1]                               
      Pars Distalis, Hyperplasia, Focal               11 [1.6]      9 [1.7]      8 [2.0]      6 [1.5]                               
      Pars Intermedia, Angiectasis                                               1 [2.0]                                            
      Pars Intermedia, Cyst                                                                   1 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Ultimobranchial Cyst                             1 [1.0]                                                                      
      C-Cell, Hyperplasia                             23 [1.2]      6 [1.3]     18 [1.3]     18 [1.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (48)         (49)                                   
      Cyst                                            12 [1.2]      4 [1.3]      8 [1.4]     13 [1.3]                               
      Hyperplasia                                      1 [1.0]      4 [2.3]                   2 [1.5]                               
      Inflammation, Chronic                            3 [1.7]      2 [2.0]      5 [1.4]      3 [1.7]                               
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             8 [1.4]      9 [1.4]     14 [1.1]      8 [1.3]                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             3 [1.0]                   1 [2.0]      3 [1.0]                               
      Hemorrhage                                       1 [4.0]                                                                      
      Hydrometra                                       1 [2.0]      2 [2.0]      1 [1.0]                                            
      Inflammation, Chronic                                                      1 [2.0]      2 [1.0]                               
      Cervix, Cyst                                                                            1                                     
      Cervix, Inflammation, Suppurative                                                       1 [1.0]                               
      Endometrium, Hyperplasia, Cystic                 2 [2.0]      1 [3.0]                                                         
   Vagina                                             (1)          (4)          (6)          (20)                                   
      Cyst                                                                       3           10                                     
      Inflammation                                                  1 [2.0]      1 [2.0]      9 [1.1]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Depletion Cellular                               1 [1.0]                                                                      
      Hyperplasia                                      5 [1.4]      8 [2.0]      5 [1.6]      3 [1.7]                               
      Myelofibrosis                                                 1 [3.0]                   2 [2.0]                               
   Lymph Node                                         (13)         (13)         (9)          (21)                                   
      Deep Cervical, Hemorrhage                        1 [2.0]                                                                      
      Deep Cervical, Hyperplasia                                                              1 [2.0]                               
      Mediastinal, Congestion                                                    2 [1.5]                                            
      Mediastinal, Hyperplasia, Lymphoid               7 [1.7]      4 [2.0]      3 [1.3]      5 [1.6]                               
      Pancreatic, Hyperplasia, Lymphoid                2 [2.0]      4 [1.8]      2 [1.0]      3 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Pigmentation                         1 [1.0]                                                                      
   Lymph Node, Mandibular                             (2)                       (1)          (3)                                    
      Hyperplasia, Lymphoid                            1 [1.0]                   1 [2.0]                                            
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (48)                                   
      Hyperplasia, Lymphoid                            1 [2.0]                                3 [1.3]                               
      Hyperplasia, Reticulum Cell                      1 [4.0]                                                                      
   Spleen                                             (47)         (49)         (50)         (48)                                   
      Fibrosis                                                      3 [1.7]      1 [1.0]                                            
      Hematopoietic Cell Proliferation                 5 [2.0]     16 [1.8]      7 [1.9]      5 [2.2]                               
      Necrosis                                                      2 [2.5]                                                         
      Pigmentation                                     8 [1.1]      9 [1.2]      6 [1.0]      1 [2.0]                               
      Lymphoid Follicle, Hyperplasia                   1 [3.0]                   1 [2.0]      1 [2.0]                               
   Thymus                                             (49)         (49)         (50)         (50)                                   
      Hemorrhage                                       2 [1.5]                   1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                            45 [1.2]     48 [1.1]     41 [1.3]     37 [1.4]                               
      Galactocele                                                   1            1                                                  
      Hyperplasia                                      2 [2.0]      3 [2.3]      4 [2.5]      2 [2.0]                               
      Hyperplasia, Atypical                            5 [1.0]      2 [1.0]      4 [1.3]      4 [1.8]                               
      Hyperplasia, Lobular                                                                    1 [3.0]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     2                         1                                     
      Hemorrhage                                                                              1 [1.0]                               
      Inflammation, Chronic                            1 [2.0]      3 [1.7]      3 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      6 [2.2]      9 [2.4]      7 [2.1]      5 [1.8]                               
      Hemorrhage                                       1 [1.0]      5 [2.0]      2 [1.5]      3 [1.3]                               
      Necrosis                                                      2 [2.0]                   1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                                          (1)          (1)                                                 
      Inflammation, Chronic, Suppurative                                         1 [4.0]                                            
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       4 [1.5]      2 [2.0]      5 [2.0]      3 [1.3]                               
      Hemorrhage                                       1 [1.0]      1 [1.0]                   1 [2.0]                               
      Infiltration Cellular, Histiocyte               45 [1.0]     47 [1.0]     46 [1.0]     45 [1.0]                               
      Inflammation, Chronic                           31 [1.0]     31 [1.0]     40 [1.0]     36 [1.1]                               
      Alveolar Epithelium, Hyperplasia                 3 [1.3]      7 [1.9]     13 [1.7]     14 [1.9]                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                  2 [1.0]      1 [1.0]      1 [1.0]                               
      Inflammation, Chronic                            2 [1.0]      3 [1.0]      4 [1.0]      6 [1.0]                               
      Inflammation, Suppurative                                                               1 [2.0]                               
      Respiratory Epithelium, Hyperplasia                                                     1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Cataract                                         2 [2.0]      2 [2.0]      2 [1.5]      1 [1.0]                               
      Inflammation, Chronic                            1 [2.0]                                2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                1 [3.0]      1 [3.0]                                            
      Infarct                                                       2 [3.5]                   2 [2.0]                               
      Inflammation, Chronic                                                                   2 [1.5]                               
      Nephropathy                                     18 [1.1]     32 [1.3]     37 [1.4]     40 [1.3]                               
      Renal Tubule, Hyperplasia                                     1 [2.0]                                                         
      Transitional Epithelium, Hyperplasia                                       2 [2.0]      2 [2.5]                               
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 [2.0]                                            
      Inflammation, Chronic                                                      1 [4.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4           15           12           12                                     
    Natural Death                                     12           11            8            9                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           24           27           28                                     
    Moribund Sacrifice                                                           1                                                  
    Natural Death                                                                2                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (48)         (50)                                   
      Edema                                                         1 [2.0]      1 [3.0]                                            
      Inflammation                                                  1 [3.0]                                                         
      Polyp, Inflammatory                                                                     1 [1.0]                               
   Intestine Large, Cecum                             (45)         (47)         (46)         (47)                                   
      Congestion                                                    1 [3.0]                                                         
      Edema                                                         1 [2.0]                                                         
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                14            4            1            1                                     
      Cholangiofibrosis                                1 [2.0]                                                                      
      Clear Cell Focus                                18           19           16           21                                     
      Cyst                                             1 [1.0]                                                                      
      Degeneration, Cystic                             3 [1.0]      9 [1.4]     11 [1.5]     15 [1.3]                               
      Eosinophilic Focus                              16            4            3            9                                     
      Hepatodiaphragmatic Nodule                       2            1            2            5                                     
      Inflammation, Granulomatous                      6 [1.0]      1 [1.0]                   1 [1.0]                               
      Mixed Cell Focus                                 8            1            5            2                                     
      Necrosis, Focal                                                            3 [1.7]      2 [1.5]                               
      Regeneration                                                  1            1                                                  
      Bile Duct, Hyperplasia                          43 [1.7]     42 [1.9]     35 [1.8]     38 [1.6]                               
      Centrilobular, Necrosis                                       1 [3.0]      1 [1.0]      5 [2.2]                               
      Hepatocyte, Vacuolization Cytoplasmic           14 [1.6]      6 [1.8]     12 [2.4]     12 [1.9]                               
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                                              1 [2.0]                                            
      Serosa, Fibrosis                                 1 [1.0]                                                                      
      Serosa, Inflammation                             1 [1.0]                                                                      
   Mesentery                                          (10)         (14)         (11)         (17)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Accessory Spleen                                              1 [1.0]      1 [2.0]                                            
      Fat, Necrosis                                    8 [2.0]      7 [2.0]      7 [1.7]      5 [2.0]                               
   Pancreas                                           (48)         (50)         (48)         (49)                                   
      Atrophy                                         23 [1.4]     28 [1.5]     25 [1.4]     23 [1.3]                               
      Cyst                                             1 [1.0]      1 [1.0]      1 [1.0]                                            
      Acinus, Hyperplasia, Focal                       3 [2.0]      5 [2.0]      1 [2.0]                                            
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic                                                      1 [1.0]      1 [2.0]                               
   Stomach, Forestomach                               (50)         (49)         (49)         (50)                                   
      Edema                                            2 [1.0]      5 [1.4]      5 [1.8]      2 [2.0]                               
      Erosion                                                       4 [1.8]      3 [1.3]      1 [1.0]                               
      Ulcer                                            2 [2.5]      5 [1.8]      5 [2.4]      3 [2.7]                               
      Epithelium, Hyperplasia                          7 [1.4]      5 [1.4]      5 [1.8]      1 [1.0]                               
   Stomach, Glandular                                 (50)         (48)         (48)         (50)                                   
      Edema                                                         5 [1.2]      3 [1.7]      1 [2.0]                               
      Erosion                                                       6 [1.8]      4 [1.5]      1 [1.0]                               
      Hyperplasia, Focal                                                         1 [2.0]                                            
      Ulcer                                                         3 [2.3]      4 [2.0]      2 [2.0]                               
   Tongue                                             (1)                                                                           
      Hyperplasia                                      1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  45 [1.5]     41 [1.4]     43 [1.4]     41 [1.5]                               
      Thrombosis                                                    4 [3.0]      1 [3.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (50)                                   
      Accessory Adrenal Cortical Nodule               26 [1.0]     18 [1.1]     20 [1.1]     14 [1.0]                               
      Degeneration, Fatty                              5 [1.6]     12 [1.3]      9 [1.4]      4 [1.0]                               
      Hyperplasia, Focal                               6 [1.0]      4 [1.0]      2 [1.0]      6 [1.0]                               
      Hypertrophy, Focal                              10 [1.3]     12 [1.3]     13 [1.5]      8 [1.4]                               
      Necrosis                                                      1 [2.0]                   1 [1.0]                               
   Adrenal Medulla                                    (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      6 [1.3]      8 [1.6]      7 [1.6]      8 [1.1]                               
      Necrosis                                                      1 [2.0]                                                         
   Islets, Pancreatic                                 (48)         (50)         (48)         (50)                                   
      Hyperplasia                                      1 [1.0]                   1 [2.0]      1 [1.0]                               
   Pituitary Gland                                    (50)         (49)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Angiectasis                      16 [1.6]     14 [2.3]     13 [2.2]      9 [2.0]                               
      Pars Distalis, Cyst                              1 [1.0]      2 [2.0]      5 [1.0]      1 [2.0]                               
      Pars Distalis, Hemorrhage                        1 [2.0]      1 [2.0]                   1 [2.0]                               
      Pars Distalis, Hyperplasia                                                              2 [2.5]                               
      Pars Distalis, Hyperplasia, Focal                6 [1.7]     10 [1.8]      4 [1.8]      3 [1.7]                               
      Pars Intermedia, Angiectasis                                               1 [1.0]                                            
      Pars Intermedia, Cyst                                         1 [1.0]      2 [1.0]                                            
      Pars Intermedia, Hyperplasia                                               1 [1.0]                                            
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Ultimobranchial Cyst                             5 [1.0]                   2 [1.0]      3 [1.0]                               
      C-Cell, Hyperplasia                              9 [1.1]     13 [1.5]     15 [1.2]      4 [1.0]                               
      Follicle, Cyst                                   4 [1.0]      2 [2.0]      2 [1.0]      2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (49)                                   
      Inflammation, Chronic                            1 [1.0]                   1 [1.0]      1 [1.0]                               
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             1 [1.0]      6 [1.3]      5 [1.8]                                            
      Hyperplasia                                                   1 [2.0]      1 [3.0]                                            
      Inflammation, Chronic                            1 [1.0]      1 [2.0]                   3 [2.3]                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                           23 [1.4]     25 [1.6]     29 [1.6]     29 [1.3]                               
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
      Inflammation                                                               1 [2.0]                                            
   Testes                                             (50)         (50)         (49)         (50)                                   
      Germinal Epithelium, Atrophy                    11 [2.3]     24 [2.0]     13 [2.6]     10 [1.8]                               
      Interstitial Cell, Hyperplasia                   1 [1.0]      5 [1.4]      4 [1.0]      4 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (48)         (50)                                   
      Depletion Cellular                                                                      1 [2.0]                               
      Hyperplasia                                      2 [1.0]      4 [1.5]      2 [2.0]      5 [1.6]                               
      Myelofibrosis                                                              3 [1.0]                                            
   Lymph Node                                         (22)         (26)         (25)         (25)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Deep Cervical, Hyperplasia, Lymphoid                          1 [2.0]                                                         
      Mediastinal, Congestion                          1 [3.0]                   1 [2.0]      2 [2.0]                               
      Mediastinal, Hyperplasia, Lymphoid               8 [1.5]      8 [1.8]     13 [1.8]     14 [1.7]                               
      Pancreatic, Congestion                           1 [2.0]                                                                      
      Pancreatic, Hyperplasia, Lymphoid                2 [1.5]      2 [2.5]      2 [1.5]      2 [1.0]                               
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Congestion                                                                 1 [1.0]      1 [1.0]                               
      Hyperplasia, Lymphoid                                         5 [1.8]      2 [1.5]      2 [1.0]                               
   Spleen                                             (50)         (50)         (49)         (49)                                   
      Fibrosis                                         2 [1.0]      2 [1.5]      2 [1.5]                                            
      Hematopoietic Cell Proliferation                 2 [1.0]      4 [1.5]      7 [1.7]      5 [1.8]                               
      Hemorrhage                                                                              1 [4.0]                               
      Necrosis                                                      2 [1.5]      2 [2.0]      2 [2.0]                               
      Pigmentation                                     4 [1.5]      1 [2.0]      4 [1.0]                                            
      Lymphoid Follicle, Hyperplasia                   1 [2.0]                                                                      
   Thymus                                             (49)         (48)         (48)         (50)                                   
      Cyst                                                                                    2 [2.0]                               
      Hemorrhage                                       1 [2.0]      2 [2.5]      3 [1.3]      2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                            15 [1.5]     17 [1.2]     17 [1.3]      8 [1.1]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        4            2            4            1                                     
      Hyperkeratosis                                   1 [2.0]                                                                      
      Hyperplasia                                                   1 [2.0]                                                         
      Inflammation, Chronic                                                      2 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hypertrophy                                                   1 [2.0]                                                         
      Cranium, Osteopetrosis                                                                  1 [1.0]                               
   Skeletal Muscle                                    (2)          (1)          (1)          (3)                                    
      Hemorrhage                                                                              1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/14/04    
Route: DOSED WATER                            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  Time: 10:12:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       50 MG/L      500 MG/L     1000                                   
                                                                                             MG/L                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Compression                                      7 [2.4]      5 [2.2]      7 [2.1]      2 [2.5]                               
      Hemorrhage                                       1 [2.0]      3 [2.3]      3 [2.7]      3 [2.7]                               
      Necrosis                                                      1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       6 [1.5]      2 [1.0]      6 [1.5]      2 [1.5]                               
      Hemorrhage                                       3 [1.3]      2 [2.5]      3 [1.7]      1 [2.0]                               
      Infiltration Cellular, Histiocyte               31 [1.0]     27 [1.0]     26 [1.2]     28 [1.0]                               
      Inflammation, Chronic                           29 [1.0]     28 [1.0]     27 [1.0]     35 [1.0]                               
      Inflammation, Suppurative                                                               1 [2.0]                               
      Alveolar Epithelium, Hyperplasia                 6 [1.8]      5 [1.8]     10 [2.3]     11 [1.9]                               
   Nose                                               (49)         (50)         (49)         (50)                                   
      Foreign Body                                    10 [1.0]      8 [1.0]     10 [1.0]      8 [1.1]                               
      Inflammation, Chronic                           14 [1.0]     13 [1.1]     14 [1.3]     14 [1.2]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Cataract                                         3 [1.3]                                                                      
      Inflammation, Chronic                            2 [1.0]                                1 [1.0]                               
   Harderian Gland                                    (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic                            1 [1.0]                                1 [3.0]                               
   Lacrimal Gland                                                                            (1)                                    
      Inflammation, Suppurative                                                               1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (49)         (50)                                   
      Cyst                                             2 [1.0]                                1 [2.0]                               
      Hydronephrosis                                   1 [1.0]                   1 [3.0]                                            
      Infarct                                          1 [2.0]      1 [1.0]                   1 [2.0]                               
      Nephropathy                                     43 [1.7]     48 [1.9]     46 [2.3]     47 [2.2]                               
      Capsule, Hemorrhage                                                        1 [2.0]                                            
      Transitional Epithelium, Hyperplasia             3 [2.0]      9 [1.4]      8 [1.0]      3 [1.0]                               
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    2 [3.0]                                                         
      Inflammation, Chronic                                                      1 [3.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
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