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TDMS Study 97013-06 Pathology Tables

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 08:51:32

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013F

       CONTRACT NUMBER:  NO1-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 2                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 3
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 4                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 64 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

485         485  106 12/02/99   106 12/02/99   1/26  Irritation Site Of Application
                 162 01/27/00   176 02/10/00   3/26  Papilloma Site Of Application Small 1

  REMOVED  **  CID   485 **   REASON - TSAC
                                184 02/18/00         Papilloma Site Of Application Small 1

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 4
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 6                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 128     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

491         491  155 01/20/00   155 01/20/00   1/26  Irritation Site Of Application

  REMOVED  **  CID   491 **   REASON - TSAC
                                184 02/18/00         Mass Torso/Ventral Small 1


495         495  134 12/30/99   134 12/30/99   1/26  Irritation Site Of Application

  REMOVED  **  CID   495 **   REASON - TSAC
                                184 02/18/00         Unremarkable

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 5
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 8                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 256     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

510         510  134 12/30/99   134 12/30/99   1/26  Irritation Site Of Application

  REMOVED  **  CID   510 **   REASON - TSAC
                                184 02/18/00         Unremarkable

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 6
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

536         536   99 11/25/99   106 12/02/99   2/24  Papilloma Site Of Application Medium 1
                 113 12/09/99   113 12/09/99   1/24  Papilloma Site Of Application Small 10
                 106 12/02/99   106 12/02/99   1/24  Papilloma Site Of Application Small 2
                 120 12/16/99   120 12/16/99   1/24  Papilloma Site Of Application Medium 2
                 162 01/27/00   162 01/27/00   1/24  Papilloma Site Of Application Small 20
                 134 12/30/99   155 01/20/00   4/24  Papilloma Site Of Application Small 5
                  57 10/14/99   127 12/23/99   3/24  Papilloma Site Of Application Small 6
                  64 10/21/99    64 10/21/99   1/24  Papilloma Site Of Application Small 7
                 120 12/16/99   120 12/16/99   1/24  Papilloma Site Of Application Small 8

  REMOVED  **  CID   536 **   REASON - Other
                                168 02/02/00         Papilloma Site Of Application Small 20


537         537   43 09/30/99    43 09/30/99   1/11  Irritation Site Of Application
                  64 10/21/99    64 10/21/99   1/11  Papilloma Site Of Application Small 12
                  71 10/28/99    71 10/28/99   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   537 **   REASON - Other
                                 76 11/02/99         Papilloma Site Of Application Small 20


538         538   99 11/25/99    99 11/25/99   1/17  Papilloma Site Of Application Small 10
                  85 11/11/99    85 11/11/99   1/17  Papilloma Site Of Application Small 2
                 106 12/02/99   106 12/02/99   1/17  Papilloma Site Of Application Small 20
                  92 11/18/99    92 11/18/99   1/17  Papilloma Site Of Application Small 7
                 113 12/09/99   113 12/09/99   1/17  Papilloma Site Of Application Medium 9
                 113 12/09/99   113 12/09/99   1/17  Papilloma Site Of Application Small 9

  REMOVED  **  CID   538 **   REASON - Other
                                114 12/10/99         Mass Torso/Ventral Medium 1
                                114 12/10/99         Papilloma Site Of Application Small 6
                                114 12/10/99         Papilloma Site Of Application Medium 9
                                114 12/10/99         Papilloma Site Of Application Large 5


539         539   50 10/07/99    50 10/07/99   1/24  Irritation Site Of Application
                 113 12/09/99   155 01/20/00   7/24  Papilloma Site Of Application Small 15
                  71 10/28/99    71 10/28/99   1/24  Papilloma Site Of Application Small 2
                 106 12/02/99   162 01/27/00   2/24  Papilloma Site Of Application Small 20
                  78 11/04/99    78 11/04/99   1/24  Papilloma Site Of Application Small 4
                  85 11/11/99    99 11/25/99   3/24  Papilloma Site Of Application Small 5

  REMOVED  **  CID   539 **   REASON - Other
                                168 02/02/00         Papilloma Site Of Application Small 20


540         540   57 10/14/99    57 10/14/99   1/11  Papilloma Site Of Application Small 12

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 7
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
540         540   64 10/21/99    64 10/21/99   1/11  Papilloma Site Of Application Small 16
                  71 10/28/99    71 10/28/99   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   540 **   REASON - Other
                                 76 11/02/99         Papilloma Site Of Application Small 20


541         541   78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 10
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 16
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 8

  REMOVED  **  CID   541 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20


542         542   57 10/14/99    57 10/14/99   1/11  Papilloma Site Of Application Small 13
                  64 10/21/99    64 10/21/99   1/11  Papilloma Site Of Application Small 17
                  71 10/28/99    71 10/28/99   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   542 **   REASON - Other
                                 76 11/02/99         Papilloma Site Of Application Small 20


543         543   64 10/21/99    64 10/21/99   1/11  Papilloma Site Of Application Small 12
                  71 10/28/99    71 10/28/99   1/11  Papilloma Site Of Application Small 20
                  57 10/14/99    57 10/14/99   1/11  Papilloma Site Of Application Small 8

  REMOVED  **  CID   543 **   REASON - Other
                                 76 11/02/99         Papilloma Site Of Application Small 20


544         544   85 11/11/99    92 11/18/99   2/14  Papilloma Site Of Application Small 20
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 8

  REMOVED  **  CID   544 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20


545         545   43 09/30/99    50 10/07/99   2/14  Irritation Site Of Application
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Medium 1
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 14
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Medium 2
                  85 11/11/99    92 11/18/99   2/14  Papilloma Site Of Application Small 20
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 9

  REMOVED  **  CID   545 **   REASON - Other

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 8
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
545         545                  96 11/22/99         Papilloma Site Of Application Small 20
                                 96 11/22/99         Papilloma Site Of Application Medium 2


546         546   64 10/21/99    64 10/21/99   1/11  Papilloma Site Of Application Small 16
                  71 10/28/99    71 10/28/99   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   546 **   REASON - Other
                                 76 11/02/99         Papilloma Site Of Application Small 20


547         547   43 09/30/99    43 09/30/99   1/14  Irritation Site Of Application
                  64 10/21/99    64 10/21/99   1/14  Papilloma Site Of Application Small 14
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 16
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 17
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 18
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20

  REMOVED  **  CID   547 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20


548         548   57 10/14/99    57 10/14/99   1/11  Papilloma Site Of Application Small 15
                  64 10/21/99    64 10/21/99   1/11  Papilloma Site Of Application Medium 16
                  71 10/28/99    71 10/28/99   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   548 **   REASON - Other
                                 76 11/02/99         Papilloma Site Of Application Small 20


549         549   71 10/28/99    78 11/04/99   2/17  Irritation Site Of Application
                 113 12/09/99   113 12/09/99   1/17  Papilloma Site Of Application Small 15
                 106 12/02/99   106 12/02/99   1/17  Papilloma Site Of Application Small 20
                  99 11/25/99    99 11/25/99   1/17  Papilloma Site Of Application Small 8

  REMOVED  **  CID   549 **   REASON - Other
                                114 12/10/99         Papilloma Site Of Application Small 20


550         550   71 10/28/99    71 10/28/99   1/14  Irritation Site Of Application
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20

  REMOVED  **  CID   550 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 9
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 1                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 10
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 3                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 64 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 11
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 5                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 128     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

431         431  148 01/13/00   148 01/13/00   1/26  Irritation Site Of Application

  REMOVED  **  CID   431 **   REASON - TSAC
                                183 02/17/00         Unremarkable

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 12
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 7                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 256     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

453         453   71 10/28/99    78 11/04/99   2/26  Irritation Site Of Application

  REMOVED  **  CID   453 **   REASON - TSAC
                                183 02/17/00         Mass Torso/Ventral Small 1

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 13
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

521         521   50 10/07/99    50 10/07/99   1/14  Irritation Site Of Application
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 16
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 8
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 9

  REMOVED  **  CID   521 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20


522         522   64 10/21/99    78 11/04/99   3/14  Papilloma Site Of Application Small 12
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 15
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20
                  57 10/14/99    57 10/14/99   1/14  Papilloma Site Of Application Small 4

  REMOVED  **  CID   522 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20


523         523   78 11/04/99    78 11/04/99   1/12  Papilloma Site Of Application Medium 1
                  71 10/28/99    71 10/28/99   1/12  Papilloma Site Of Application Small 17
                  78 11/04/99    78 11/04/99   1/12  Papilloma Site Of Application Small 20
                  64 10/21/99    64 10/21/99   1/12  Papilloma Site Of Application Medium 8
                  57 10/14/99    57 10/14/99   1/12  Papilloma Site Of Application Small 8

  REMOVED  **  CID   523 **   REASON - Other
                                 79 11/05/99         Papilloma Site Of Application Small 20


524         524   71 10/28/99    78 11/04/99   2/14  Papilloma Site Of Application Medium 1
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 11
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 13
                  85 11/11/99    92 11/18/99   2/14  Papilloma Site Of Application Medium 2
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20
                  57 10/14/99    64 10/21/99   2/14  Papilloma Site Of Application Small 3
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 4

  REMOVED  **  CID   524 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20
                                 96 11/22/99         Papilloma Site Of Application Medium 2


525         525   50 10/07/99    50 10/07/99   1/14  Irritation Site Of Application
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Medium 1
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 11
                  85 11/11/99    92 11/18/99   2/14  Papilloma Site Of Application Medium 2
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 7

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 14
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
525         525   78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 9

  REMOVED  **  CID   525 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20


526         526   85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Medium 1
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 12
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 16
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Medium 2
                  57 10/14/99    57 10/14/99   1/14  Papilloma Site Of Application Small 2
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20
                  64 10/21/99    64 10/21/99   1/14  Papilloma Site Of Application Small 3
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 7

  REMOVED  **  CID   526 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20
                                 96 11/22/99         Papilloma Site Of Application Medium 2


527         527   71 10/28/99    71 10/28/99   1/12  Papilloma Site Of Application Small 18
                  78 11/04/99    78 11/04/99   1/12  Papilloma Site Of Application Small 20
                  64 10/21/99    64 10/21/99   1/12  Papilloma Site Of Application Small 9

  REMOVED  **  CID   527 **   REASON - Other
                                 79 11/05/99         Papilloma Site Of Application Small 20


528         528   78 11/04/99    78 11/04/99   1/12  Papilloma Site Of Application Medium 1
                  71 10/28/99    78 11/04/99   2/12  Papilloma Site Of Application Small 11
                  64 10/21/99    64 10/21/99   1/12  Papilloma Site Of Application Small 6

  REMOVED  **  CID   528 **   REASON - NATD
                                 83 11/09/99         Papilloma Site Of Application Small 7
                                 83 11/09/99         Papilloma Site Of Application Medium 2
                                 83 11/09/99         Papilloma Site Of Application Large 6


529         529   64 10/21/99    64 10/21/99   1/10  Papilloma Site Of Application Small 8

  REMOVED  **  CID   529 **   REASON - NATD
                                 71 10/28/99         Papilloma Site Of Application Small 7


530         530   50 10/07/99    50 10/07/99   1/8   Irritation Site Of Application

  REMOVED  **  CID   530 **   REASON - NATD

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 15
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
530         530                  54 10/11/99         Unremarkable


531         531  113 12/09/99   120 12/16/99   2/19  Papilloma Site Of Application Medium 10
                  92 11/18/99    92 11/18/99   1/19  Papilloma Site Of Application Small 12
                  99 11/25/99    99 11/25/99   1/19  Papilloma Site Of Application Medium 12
                 106 12/02/99   106 12/02/99   1/19  Papilloma Site Of Application Medium 13
                 127 12/23/99   127 12/23/99   1/19  Papilloma Site Of Application Medium 20
                  85 11/11/99    92 11/18/99   2/19  Papilloma Site Of Application Medium 3
                  99 11/25/99   106 12/02/99   2/19  Papilloma Site Of Application Small 3
                  64 10/21/99    64 10/21/99   1/19  Papilloma Site Of Application Small 4
                 113 12/09/99   120 12/16/99   2/19  Papilloma Site Of Application Large 6
                  71 10/28/99   120 12/16/99   3/19  Papilloma Site Of Application Small 7
                  78 11/04/99    78 11/04/99   1/19  Papilloma Site Of Application Small 8
                  85 11/11/99    85 11/11/99   1/19  Papilloma Site Of Application Small 9

  REMOVED  **  CID   531 **   REASON - Other
                                131 12/27/99         Papilloma Site Of Application Small 20


532         532   71 10/28/99    78 11/04/99   2/17  Irritation Site Of Application
                 106 12/02/99   106 12/02/99   1/17  Papilloma Site Of Application Medium 1
                  99 11/25/99   106 12/02/99   2/17  Papilloma Site Of Application Small 11
                 113 12/09/99   113 12/09/99   1/17  Papilloma Site Of Application Small 20

  REMOVED  **  CID   532 **   REASON - Other
                                118 12/14/99         Papilloma Site Of Application Small 20


533         533   50 10/07/99    50 10/07/99   1/14  Irritation Site Of Application
                  78 11/04/99    92 11/18/99   3/14  Papilloma Site Of Application Medium 1
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 10
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Small 15
                  92 11/18/99    92 11/18/99   1/14  Papilloma Site Of Application Small 20
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 8

  REMOVED  **  CID   533 **   REASON - Other
                                 96 11/22/99         Papilloma Site Of Application Small 20


534         534   50 10/07/99    50 10/07/99   1/14  Irritation Site Of Application
                  71 10/28/99    71 10/28/99   1/14  Papilloma Site Of Application Small 13
                  78 11/04/99    78 11/04/99   1/14  Papilloma Site Of Application Small 18
                  85 11/11/99    85 11/11/99   1/14  Papilloma Site Of Application Medium 2
                  85 11/11/99    92 11/18/99   2/14  Papilloma Site Of Application Small 20

  REMOVED  **  CID   534 **   REASON - Other

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 16
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:51:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
534         534                  96 11/22/99         Papilloma Site Of Application Small 20



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                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------